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Aliases for SHISA8 Gene

Aliases for SHISA8 Gene

  • Shisa Family Member 8 2 3 5
  • C22orf17 3 4
  • Chromosome 22 Open Reading Frame 17 2
  • Shisa Homolog 8 (Xenopus Laevis) 2
  • Putative Protein Shisa-8 3
  • Shisa Homolog 8 3
  • CTA-250D10.17 3
  • Orf26 3

External Ids for SHISA8 Gene

Previous HGNC Symbols for SHISA8 Gene

  • C22orf17

Previous GeneCards Identifiers for SHISA8 Gene

  • GC22M040636
  • GC22M042305

Summaries for SHISA8 Gene

GeneCards Summary for SHISA8 Gene

SHISA8 (Shisa Family Member 8) is a Protein Coding gene. An important paralog of this gene is SHISA9.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHISA8 Gene

Genomics for SHISA8 Gene

Regulatory Elements for SHISA8 Gene

Enhancers for SHISA8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F041883 0.8 FANTOM5 ENCODE 12.9 +31.0 31011 1.3 SCRT1 ZNF263 SCRT2 CREM CYP2D6 SHISA8 SREBF2 TNFRSF13C MIR378I CENPM RNU6ATAC22P WBP2NL SMDT1 MEI1
GH22F041884 0.7 ENCODE 12.7 +29.4 29437 1.6 ELF3 SAP130 MLX ARID4B RAD21 ZNF48 YY1 ZBTB48 GATAD1 HNF4G CYP2D6 SHISA8 SREBF2 TNFRSF13C MIR378I CENPM RNU6ATAC22P SMDT1 LOC105373045 MIR33A
GH22F041840 0.7 ENCODE 12.6 +73.9 73921 1.8 SCRT1 KLF1 KLF4 TEAD3 POLR2A SCRT2 PRDM10 PRDM1 MAFK ZNF18 MIR33A SHISA8 CENPM RNU6ATAC22P CYP2D6 MEI1 NDUFA6 ENSG00000184068 LOC105373045
GH22F041931 1.6 FANTOM5 Ensembl ENCODE 5.1 -21.7 -21663 10.8 HDGF PKNOX1 WRNIP1 SIN3A ARID4B YBX1 ZNF2 ZNF121 GLIS2 ZNF143 TNFRSF13C MEI1 SMDT1 CYP2D6 CENPM SHISA8 CSDC2 GC22P041934
GH22F041916 1.7 FANTOM5 Ensembl ENCODE 3.4 -8.3 -8320 12.9 HDGF MLX WRNIP1 ARID4B FEZF1 DMAP1 ZNF2 SLC30A9 ZNF143 ZNF207 NDUFA6 SMDT1 TNFRSF13C CYP2D8P CSDC2 CENPM SHISA8 GC22M041929 MIR378I
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SHISA8 on UCSC Golden Path with GeneCards custom track

Promoters for SHISA8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001843869 193 601 SUZ12 UBTF ZIC2 ZEB1 GLIS2 POLR2A SCRT2 E2F6 EZH2 SP3

Genomic Location for SHISA8 Gene

Chromosome:
22
Start:
41,909,533 bp from pter
End:
41,915,093 bp from pter
Size:
5,561 bases
Orientation:
Minus strand

Genomic View for SHISA8 Gene

Genes around SHISA8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHISA8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHISA8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHISA8 Gene

Proteins for SHISA8 Gene

  • Protein details for SHISA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B8ZZ34-SHSA8_HUMAN
    Recommended name:
    Putative protein shisa-8
    Protein Accession:
    B8ZZ34

    Protein attributes for SHISA8 Gene

    Size:
    492 amino acids
    Molecular mass:
    51412 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAX14868.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAX14868.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for SHISA8 Gene

Post-translational modifications for SHISA8 Gene

  • Glycosylation at Asn 75
  • Modification sites at PhosphoSitePlus

Other Protein References for SHISA8 Gene

No data available for DME Specific Peptides for SHISA8 Gene

Domains & Families for SHISA8 Gene

Gene Families for SHISA8 Gene

Protein Domains for SHISA8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SHISA8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

B8ZZ34

UniProtKB/Swiss-Prot:

SHSA8_HUMAN :
  • Belongs to the shisa family.
Family:
  • Belongs to the shisa family.
genes like me logo Genes that share domains with SHISA8: view

Function for SHISA8 Gene

Phenotypes for SHISA8 Gene

genes like me logo Genes that share phenotypes with SHISA8: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SHISA8 Gene

Localization for SHISA8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHISA8 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SHISA8 gene
Compartment Confidence
plasma membrane 4
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SHISA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0032281 AMPA glutamate receptor complex IBA --
GO:0045202 synapse IBA --
genes like me logo Genes that share ontologies with SHISA8: view

Pathways & Interactions for SHISA8 Gene

SuperPathways for SHISA8 Gene

No Data Available

Interacting Proteins for SHISA8 Gene

Gene Ontology (GO) - Biological Process for SHISA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048172 regulation of short-term neuronal synaptic plasticity IBA --
genes like me logo Genes that share ontologies with SHISA8: view

No data available for Pathways by source and SIGNOR curated interactions for SHISA8 Gene

Transcripts for SHISA8 Gene

mRNA/cDNA for SHISA8 Gene

(4) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SHISA8 Gene

Shisa homolog 8 (Xenopus laevis):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHISA8 Gene

No ASD Table

Relevant External Links for SHISA8 Gene

GeneLoc Exon Structure for
SHISA8
ECgene alternative splicing isoforms for
SHISA8

Expression for SHISA8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SHISA8 Gene

mRNA differential expression in normal tissues according to GTEx for SHISA8 Gene

This gene is overexpressed in Brain - Cerebellum (x18.5), Brain - Cerebellar Hemisphere (x18.3), and Adrenal Gland (x5.0).

Protein differential expression in normal tissues from HIPED for SHISA8 Gene

This gene is overexpressed in Heart (40.4) and Brain (28.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SHISA8 Gene



Protein tissue co-expression partners for SHISA8 Gene

NURSA nuclear receptor signaling pathways regulating expression of SHISA8 Gene:

SHISA8

SOURCE GeneReport for Unigene cluster for SHISA8 Gene:

Hs.526704
genes like me logo Genes that share expression patterns with SHISA8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SHISA8 Gene

Orthologs for SHISA8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SHISA8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SHISA8 34 35
  • 95.87 (n)
dog
(Canis familiaris)
Mammalia SHISA8 34
  • 85.8 (n)
rat
(Rattus norvegicus)
Mammalia Shisa8 34
  • 79.58 (n)
mouse
(Mus musculus)
Mammalia AI848285 34
  • 79.49 (n)
Shisa8 16
platypus
(Ornithorhynchus anatinus)
Mammalia SHISA8 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves SHISA8 34
  • 67.74 (n)
lizard
(Anolis carolinensis)
Reptilia SHISA8 35
  • 22 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489046 34
  • 50.66 (n)
zebrafish
(Danio rerio)
Actinopterygii SHISA8 (2 of 2) 35
  • 35 (a)
OneToMany
SHISA8 (1 of 2) 35
  • 17 (a)
OneToMany
Species where no ortholog for SHISA8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHISA8 Gene

ENSEMBL:
Gene Tree for SHISA8 (if available)
TreeFam:
Gene Tree for SHISA8 (if available)

Paralogs for SHISA8 Gene

Paralogs for SHISA8 Gene

(1) SIMAP similar genes for SHISA8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SHISA8: view

Variants for SHISA8 Gene

Sequence variations from dbSNP and Humsavar for SHISA8 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs10708799 -- 41,913,990(+) GTGTT(-/G)GGGGG intron-variant
rs111472819 -- 41,914,533(+) GCGGG(A/C)CCCTG reference, synonymous-codon
rs111744155 -- 41,910,369(+) TCGTG(C/G)GCCCA intron-variant
rs112316432 -- 41,909,768(+) CTTCA(C/G)ACGGT reference, synonymous-codon
rs112648327 -- 41,911,989(+) GCCTC(C/T)CAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SHISA8 Gene

Variant ID Type Subtype PubMed ID
nsv955162 CNV deletion 24416366
nsv589053 CNV loss 21841781
nsv508736 CNV insertion 20534489
nsv1118954 CNV deletion 24896259
nsv1057208 CNV gain 25217958

Relevant External Links for SHISA8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SHISA8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SHISA8 Gene

Disorders for SHISA8 Gene

Relevant External Links for SHISA8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SHISA8

No disorders were found for SHISA8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHISA8 Gene

Publications for SHISA8 Gene

  1. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3 64
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 4 64

Products for SHISA8 Gene

Sources for SHISA8 Gene

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