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Aliases for SHISA8 Gene

Aliases for SHISA8 Gene

  • Shisa Family Member 8 2 3
  • C22orf17 3 4
  • Chromosome 22 Open Reading Frame 17 2
  • Shisa Homolog 8 (Xenopus Laevis) 2
  • Putative Protein Shisa-8 3
  • Shisa Homolog 8 3
  • CTA-250D10.17 3
  • ORF26 3

External Ids for SHISA8 Gene

Previous HGNC Symbols for SHISA8 Gene

  • C22orf17

Previous GeneCards Identifiers for SHISA8 Gene

  • GC22M040636
  • GC22M042305

Summaries for SHISA8 Gene

GeneCards Summary for SHISA8 Gene

SHISA8 (Shisa Family Member 8) is a Protein Coding gene. An important paralog of this gene is SHISA6.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHISA8 Gene

Genomics for SHISA8 Gene

Genomic Location for SHISA8 Gene

Start:
41,909,533 bp from pter
End:
41,914,701 bp from pter
Size:
5,169 bases
Orientation:
Minus strand

Genomic View for SHISA8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SHISA8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHISA8 Gene

No data available for Regulatory Elements for SHISA8 Gene

Proteins for SHISA8 Gene

  • Protein details for SHISA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B8ZZ34-SHSA8_HUMAN
    Recommended name:
    Putative protein shisa-8
    Protein Accession:
    B8ZZ34
    Secondary Accessions:

    Protein attributes for SHISA8 Gene

    Size:
    492 amino acids
    Molecular mass:
    51412 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAX14868.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAX14868.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for SHISA8 Gene

Proteomics data for SHISA8 Gene at MOPED

Post-translational modifications for SHISA8 Gene

  • Glycosylation at Asn75
  • Modification sites at PhosphoSitePlus

Other Protein References for SHISA8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHISA8 Gene

Domains for SHISA8 Gene

Gene Families for SHISA8 Gene

HGNC:

Protein Domains for SHISA8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SHISA8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

B8ZZ34

UniProtKB/Swiss-Prot:

SHSA8_HUMAN :
  • B8ZZ34
Family:
  • Belongs to the shisa family.
genes like me logo Genes that share domains with SHISA8: view

Function for SHISA8 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SHISA8 Gene

Localization for SHISA8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHISA8 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SHISA8 Gene COMPARTMENTS Subcellular localization image for SHISA8 gene
Compartment Confidence
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SHISA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SHISA8: view

Pathways for SHISA8 Gene

SuperPathways for SHISA8 Gene

No Data Available

Interacting Proteins for SHISA8 Gene

Gene Ontology (GO) - Biological Process for SHISA8 Gene

None

No data available for Pathways by source for SHISA8 Gene

Transcripts for SHISA8 Gene

mRNA/cDNA for SHISA8 Gene

(4) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SHISA8 Gene

Shisa homolog 8 (Xenopus laevis):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SHISA8

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHISA8 Gene

No ASD Table

Relevant External Links for SHISA8 Gene

GeneLoc Exon Structure for
SHISA8
ECgene alternative splicing isoforms for
SHISA8

Expression for SHISA8 Gene

mRNA expression in normal human tissues for SHISA8 Gene

mRNA differential expression in normal tissues according to GTEx for SHISA8 Gene

This gene is overexpressed in Brain - Cerebellum (18.5), Brain - Cerebellar Hemisphere (18.3), and Adrenal Gland (5.0).

Protein differential expression in normal tissues for SHISA8 Gene

This gene is overexpressed in Heart (40.4) and Brain (28.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SHISA8 Gene

SOURCE GeneReport for Unigene cluster for SHISA8 Gene Hs.526704

genes like me logo Genes that share expressions with SHISA8: view

Expression partners for SHISA8 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SHISA8 Gene

Orthologs for SHISA8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SHISA8 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SHISA8 35
  • 85.8 (n)
  • 81.16 (a)
mouse
(Mus musculus)
Mammalia AI848285 35
  • 79.49 (n)
  • 79.24 (a)
chimpanzee
(Pan troglodytes)
Mammalia SHISA8 35
  • 95.87 (n)
  • 96.51 (a)
SHISA8 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Shisa8 35
  • 79.58 (n)
  • 79.49 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia SHISA8 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves SHISA8 35
  • 67.74 (n)
  • 61.29 (a)
lizard
(Anolis carolinensis)
Reptilia SHISA8 36
  • 22 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489046 35
  • 50.66 (n)
  • 45.57 (a)
zebrafish
(Danio rerio)
Actinopterygii SHISA8 (1 of 2) 36
  • 17 (a)
OneToMany
SHISA8 (2 of 2) 36
  • 35 (a)
OneToMany
Species with no ortholog for SHISA8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHISA8 Gene

ENSEMBL:
Gene Tree for SHISA8 (if available)
TreeFam:
Gene Tree for SHISA8 (if available)

Paralogs for SHISA8 Gene

Paralogs for SHISA8 Gene

Selected SIMAP similar genes for SHISA8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SHISA8: view

Variants for SHISA8 Gene

Sequence variations from dbSNP and Humsavar for SHISA8 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs1894711 -- 41,914,060(+) GCTTC(G/T)AGAGC intron-variant
rs5751178 -- 41,913,129(+) GCTCC(C/T)TGGGA intron-variant
rs5758504 -- 41,912,735(+) GGAGT(C/T)GGGGC intron-variant
rs5758505 -- 41,912,912(+) ACCAT(C/G/T)GCAGC intron-variant
rs5758506 -- 41,913,118(+) CTTCC(C/T)TTAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SHISA8 Gene

Variant ID Type Subtype PubMed ID
nsv508736 CNV Insertion 20534489
dgv4979n71 CNV Loss 21882294
dgv4980n71 CNV Loss 21882294

Relevant External Links for SHISA8 Gene

HapMap Linkage Disequilibrium report
SHISA8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHISA8 Gene

Disorders for SHISA8 Gene

No disorders were found for SHISA8 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SHISA8 Gene

Publications for SHISA8 Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 4

Products for SHISA8 Gene

Sources for SHISA8 Gene

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