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SHISA7 Gene

protein-coding   GIFtS: 35
GCID: GC19M055940

Shisa Family Member 7

(Previous name: shisa homolog 7 (Xenopus laevis))
  Search for SHISA7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Shisa Family Member 71 2
Shisa Homolog 7 (Xenopus Laevis)1
Protein Shisa-72
Shisa Homolog 72
UPF0626 Protein A2
Protein Shisa-6-Like3

External Ids:    HGNC: 354091   Entrez Gene: 7299562   Ensembl: ENSG000001879027   UniProtKB: A6NL883   

Export aliases for SHISA7 gene to outside databases

Previous GC identifers: GC19M060639 GC19M052263


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SHISA7 Gene:
SHISA7 (shisa family member 7) is a protein-coding gene. An important paralog of this gene is SHISA6.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SHISA7
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SHISA7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SHISA7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

SHISA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHISA7 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M055940:  view genomic region     (about GC identifiers)

Start:
55,940,105 bp from pter      End:
55,954,230 bp from pter
Size:
14,126 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SHSA7_HUMAN, A6NL88 (See protein sequence)
Recommended Name: Protein shisa-7 precursor  
Size: 538 amino acids; 56214 Da

Explore the universe of human proteins at neXtProt for SHISA7: NX_A6NL88

Explore proteomics data for SHISA7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn23, Asn59
  • Modification sites at PhosphoSitePlus

  • See SHISA7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001138648.1  
    ENSEMBL proteins: 
     ENSP00000365503   ENSP00000401307  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SHISA: Shisa homologs

    1 InterPro protein domain:
     IPR026910 Shisa

    Graphical View of Domain Structure for InterPro Entry A6NL88

    ProtoNet protein and cluster: A6NL88

    UniProtKB/Swiss-Prot: SHSA7_HUMAN, A6NL88
    Similarity: Belongs to the shisa family


    SHISA7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SHISA7
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SHSA7_HUMAN, A6NL88: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    plasma membrane2
    golgi apparatus1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    SHISA7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SHISA7
    Interactions:

        Search GeneGlobe Interaction Network for SHISA7

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SHISA7 (SHSA7)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SHISA7 gene (2 alternative transcripts): 
    NM_175908.3  NM_001145176.1  

    Unigene Cluster for SHISA7:

    Shisa homolog 7 (Xenopus laevis)
    Hs.6664  [show with all ESTs]
    Unigene Representative Sequence: NM_001145176
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376325(uc002qkz.3) ENST00000416792
    miRNA
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    Additional mRNA sequence: 

    AK091660.1 AK094959.1 AK127223.1 AL831832.1 BC093900.1 BC112197.1 

    2 DOTS entries:

    DT.312185  DT.121471622 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SHISA7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGGGGGCA
    SHISA7 Expression
    About this image

    SHISA7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SHISA7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.6664
        Custom PCR Arrays for SHISA7
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SHISA7 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Shisa71 , 5 shisa homolog 7 (Xenopus laevis)1, 5 87.44(n)1
    93.5(a)1
      7 (2.79 cM)5
    2328131  NM_172737.41  NP_766325.31 
     48255525 
    lizard
    (Anolis carolinensis)
    Reptilia SHISA76
    shisa family member 7
    43(a)
    1 ↔ 1
    GL343279.1(1415278-1428822)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia shisa71 shisa homolog 7 (Xenopus laevis) 58.91(n)
    57.6(a)
      100494066  XM_002939964.2  XP_002940010.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018831301 protein shisa-7-like 56.22(n)
    52.61(a)
      101883130  XM_005157907.1  XP_005157964.1 


    ENSEMBL Gene Tree for SHISA7 (if available)
    TreeFam Gene Tree for SHISA7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SHISA7 gene
    SHISA62  SHISA82  SHISA92  

    SHISA7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SHISA7 (see all 321)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1478289611,2
    --55939733(+) TGAGCC/TATGAA 1 -- ds50010--------
    rs1413197501,2
    --55939790(+) CTATTC/TGGCCA 1 -- ds50010--------
    rs1503842651,2
    --55939842(+) CAAATG/TCTCAC 1 -- ds50010--------
    rs1181339691,2
    C,F--55939871(+) GCTTTG/CTTAGG 1 -- ds50011Minor allele frequency- C:0.04EA 120
    rs1450860731,2
    --55939960(+) TGGCCC/TGGGAA 1 -- ds50010--------
    rs1112617021,2
    F--55940013(+) ACACCG/CAGCTA 1 -- ds50011Minor allele frequency- C:0.50CSA 2
    rs1430311191,2
    C--55940313(+) TCCCCC/TAACCA 1 -- ut310--------
    rs1444779261,2
    C--55940333(+) ATGCC-/TGTGTGT 1 -- ut310--------
    rs1910362461,2
    --55940349(+) GCTTGC/TGTATG 1 -- ut310--------
    rs1833936091,2
    --55940492(+) GCTTAC/TTTGAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SHISA7 (55940105 - 55954230 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SHISA7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912478CNV Loss21882294
    nsv912473CNV Loss21882294
    nsv912457CNV Loss21882294
    nsv912463CNV Loss21882294
    dgv600n67CNV Loss20364138
    dgv4021n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SHISA7 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SHISA7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 729956 HGNC: 35409 Ensembl:ENSG00000187902 euGenes: HUgn729956 ECgene: SHISA7
    H-InvDB: SHISA7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SHISA7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SHISA7 gene:
    Search GeneIP for patents involving SHISA7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Search ThermoFisher Antibodies for SHISA7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHISA7
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SHISA7
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SHISA7
     LSBio Antibodies in human, mouse, rat for SHISA7
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