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Aliases for SHISA7 Gene

Aliases for SHISA7 Gene

  • Shisa Family Member 7 2 3 5
  • Shisa Homolog 7 (Xenopus Laevis) 2
  • Protein Shisa-6-Like 4

External Ids for SHISA7 Gene

Previous GeneCards Identifiers for SHISA7 Gene

  • GC19M060639
  • GC19M055940
  • GC19M052263

Summaries for SHISA7 Gene

GeneCards Summary for SHISA7 Gene

SHISA7 (Shisa Family Member 7) is a Protein Coding gene. An important paralog of this gene is SHISA6.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHISA7 Gene

Genomics for SHISA7 Gene

Regulatory Elements for SHISA7 Gene

Enhancers for SHISA7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G055519 1.6 FANTOM5 Ensembl ENCODE 22.2 -77.3 -77347 1.0 HDGF ATF1 ZNF493 ZNF133 YBX1 GLI4 ZNF416 FOS ZNF548 SP3 FIZ1 ZNF471 NAT14 ZNF580 ZNF667 ZNF582-AS1 ZNF667-AS1 ZNF542P U2AF2 ZNF583
GH19G055431 0.8 dbSUPER 33.4 +10.0 9993 3.2 CTCF CBX3 ATF1 ZBTB21 JUN ZFP64 TSC22D4 ZNF266 CDC5L CEBPG SHISA7 ENSG00000235681 LENG8-AS1 U2AF2 PIR40571
GH19G055419 0.5 dbSUPER 35.7 +22.8 22832 2.5 CBX3 ZNF680 SETDB1 TRIM28 SHISA7 ISOC2 ZNF628 RPL28 TMEM238 BRSK1 TMEM190 TNNT1 HSPBP1 PPP6R1
GH19G055450 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -9.1 -9112 3.3 PKNOX1 ATF1 CREB3L1 ARNT AGO1 FOS SP3 MCM3 YY2 NFYC SHISA7 BRSK1 SYT5 ZNF580 ISOC2
GH19G055516 1.5 Ensembl ENCODE dbSUPER 11.1 -74.3 -74304 1.3 HDGF ATF1 ARID4B SIN3A GLI4 BRCA1 CBX5 ZNF143 FOS KLF13 SBK2 SBK3 SSC5D NAT14 ZNF580 ZNF581 CCDC106 ZNF628 FIZ1 ZNF524
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SHISA7 on UCSC Golden Path with GeneCards custom track

Genomic Location for SHISA7 Gene

Chromosome:
19
Start:
55,428,738 bp from pter
End:
55,442,863 bp from pter
Size:
14,126 bases
Orientation:
Minus strand

Genomic View for SHISA7 Gene

Genes around SHISA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHISA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHISA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHISA7 Gene

Proteins for SHISA7 Gene

  • Protein details for SHISA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NL88-SHSA7_HUMAN
    Recommended name:
    Protein shisa-7
    Protein Accession:
    A6NL88

    Protein attributes for SHISA7 Gene

    Size:
    538 amino acids
    Molecular mass:
    56214 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SHISA7 Gene

Post-translational modifications for SHISA7 Gene

  • Glycosylation at Asn23 and isoforms=59
  • Modification sites at PhosphoSitePlus

Other Protein References for SHISA7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHISA7 Gene

Domains & Families for SHISA7 Gene

Gene Families for SHISA7 Gene

Protein Domains for SHISA7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SHISA7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NL88

UniProtKB/Swiss-Prot:

SHSA7_HUMAN :
  • Belongs to the shisa family.
Family:
  • Belongs to the shisa family.
genes like me logo Genes that share domains with SHISA7: view

Function for SHISA7 Gene

Phenotypes for SHISA7 Gene

GenomeRNAi human phenotypes for SHISA7:
genes like me logo Genes that share phenotypes with SHISA7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SHISA7 Gene

Localization for SHISA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHISA7 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SHISA7 gene
Compartment Confidence
plasma membrane 4
extracellular 2
mitochondrion 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SHISA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0032281 AMPA glutamate receptor complex IBA --
GO:0045202 synapse IBA --
genes like me logo Genes that share ontologies with SHISA7: view

Pathways & Interactions for SHISA7 Gene

SuperPathways for SHISA7 Gene

No Data Available

Interacting Proteins for SHISA7 Gene

Gene Ontology (GO) - Biological Process for SHISA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048172 regulation of short-term neuronal synaptic plasticity IBA --
genes like me logo Genes that share ontologies with SHISA7: view

No data available for Pathways by source and SIGNOR curated interactions for SHISA7 Gene

Drugs & Compounds for SHISA7 Gene

No Compound Related Data Available

Transcripts for SHISA7 Gene

mRNA/cDNA for SHISA7 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SHISA7 Gene

Shisa homolog 7 (Xenopus laevis):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHISA7 Gene

No ASD Table

Relevant External Links for SHISA7 Gene

GeneLoc Exon Structure for
SHISA7
ECgene alternative splicing isoforms for
SHISA7

Expression for SHISA7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SHISA7 Gene

mRNA differential expression in normal tissues according to GTEx for SHISA7 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.5), Brain - Cortex (x5.8), Brain - Putamen (basal ganglia) (x5.0), Brain - Caudate (basal ganglia) (x4.8), Brain - Hippocampus (x4.7), Brain - Anterior cingulate cortex (BA24) (x4.4), Brain - Amygdala (x4.2), and Brain - Frontal Cortex (BA9) (x4.1).

Protein differential expression in normal tissues from HIPED for SHISA7 Gene

This gene is overexpressed in Frontal cortex (61.6) and Fetal Liver (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SHISA7 Gene



Protein tissue co-expression partners for SHISA7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SHISA7 Gene:

SHISA7

SOURCE GeneReport for Unigene cluster for SHISA7 Gene:

Hs.6664

Evidence on tissue expression from TISSUES for SHISA7 Gene

  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with SHISA7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SHISA7 Gene

Orthologs for SHISA7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SHISA7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SHISA7 34 35
  • 91.35 (n)
dog
(Canis familiaris)
Mammalia SHISA7 34 35
  • 90.11 (n)
mouse
(Mus musculus)
Mammalia Shisa7 34 16 35
  • 87.44 (n)
rat
(Rattus norvegicus)
Mammalia Shisa7 34
  • 87.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SHISA7 35
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SHISA7 35
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia shisa7 34
  • 58.91 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101883130 34
  • 56.22 (n)
SHISA7 (1 of 2) 35
  • 33 (a)
OneToMany
shisa7 35
  • 27 (a)
OneToMany
Species where no ortholog for SHISA7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHISA7 Gene

ENSEMBL:
Gene Tree for SHISA7 (if available)
TreeFam:
Gene Tree for SHISA7 (if available)

Paralogs for SHISA7 Gene

Paralogs for SHISA7 Gene

genes like me logo Genes that share paralogs with SHISA7: view

Variants for SHISA7 Gene

Sequence variations from dbSNP and Humsavar for SHISA7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000102308 -- 55,444,775(+) GAACC(C/T)GATCT upstream-variant-2KB
rs1000452962 -- 55,444,511(+) TCAAA(A/T)GAGAG upstream-variant-2KB
rs1000500289 -- 55,432,582(+) AATGA(C/T)GACAT utr-variant-3-prime
rs1000661259 -- 55,440,362(+) ACCTA(C/T)ATCAC intron-variant
rs1000761622 -- 55,432,873(+) GCTTT(G/T)TCCCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SHISA7 Gene

Variant ID Type Subtype PubMed ID
dgv600n67 CNV loss 20364138
esv3331220 CNV duplication 20981092
nsv1078448 CNV duplication 25765185
nsv1118621 CNV duplication 24896259
nsv953624 CNV deletion 24416366

Variation tolerance for SHISA7 Gene

Gene Damage Index Score: 0.64; 13.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SHISA7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SHISA7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHISA7 Gene

Disorders for SHISA7 Gene

Relevant External Links for SHISA7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SHISA7

No disorders were found for SHISA7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHISA7 Gene

Publications for SHISA7 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  4. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3 64

Products for SHISA7 Gene

Sources for SHISA7 Gene

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