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SHISA6 Gene

protein-coding   GIFtS: 45
GCID: GC17P011144

Shisa Family Member 6

(Previous name: shisa homolog 6 (Xenopus laevis))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Shisa Family Member 61 2
Shisa Homolog 6 (Xenopus Laevis)1
Protein Shisa-6 Homolog2
Shisa Homolog 62

External Ids:    HGNC: 344911   Entrez Gene: 3883362   Ensembl: ENSG000001888037   UniProtKB: Q6ZSJ93   

Export aliases for SHISA6 gene to outside databases

Previous GC identifers: GC17P011086 GC17P011046


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SHISA6 Gene:
SHISA6 (shisa family member 6) is a protein-coding gene. Diseases associated with SHISA6 include refractive error, and myopia. An important paralog of this gene is SHISA8.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010718.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SHISA6
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SHISA6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SHISA6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p12   Ensembl cytogenetic band:  17p12   HGNC cytogenetic band: 17p13.1-p12

SHISA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHISA6 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P011144:  view genomic region     (about GC identifiers)

Start:
11,144,580 bp from pter      End:
11,467,380 bp from pter
Size:
322,801 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SHSA6_HUMAN, Q6ZSJ9 (See protein sequence)
Recommended Name: Protein shisa-6 homolog precursor  
Size: 500 amino acids; 55764 Da
Sequence caution: Sequence=BAC86949.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAG54617.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KXV5 Q4PL63
Alternative splicing: 3 isoforms:  Q6ZSJ9-1   Q6ZSJ9-2   Q6ZSJ9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SHISA6: NX_Q6ZSJ9

Explore proteomics data for SHISA6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn32, Asn59
  • Modification sites at PhosphoSitePlus

  • See SHISA6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001166932.1  NP_001166933.1  NP_997269.2  

    ENSEMBL proteins: 
     ENSP00000390084   ENSP00000388659   ENSP00000387157   ENSP00000477331  

    SHISA6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Custom Protein Services for SHISA6
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SHISA6

    SHISA6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SHISA6
    Novus Biologicals SHISA6 Antibodies
    Abcam antibodies for SHISA6
    Cloud-Clone Corp. Antibodies for SHISA6
    Search ThermoFisher Antibodies for SHISA6
    LSBio Antibodies in human, mouse, rat for SHISA6

    SHISA6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SHISA6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SHISA6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SHISA6
    Cloud-Clone Corp. CLIAs for SHISA6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SHISA: Shisa homologs

    1 InterPro protein domain:
     IPR026910 Shisa

    Graphical View of Domain Structure for InterPro Entry Q6ZSJ9

    ProtoNet protein and cluster: Q6ZSJ9

    UniProtKB/Swiss-Prot: SHSA6_HUMAN, Q6ZSJ9
    Similarity: Belongs to the shisa family


    SHISA6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for SHISA6:
     Decreased viability with cispl 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SHISA6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SHISA6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SHISA6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SHISA6

    miRNA
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    Block miRNA regulation of human, mouse, rat SHISA6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SHISA6 (see all 103):
    hsa-miR-194* hsa-miR-4254 hsa-miR-128 hsa-miR-374a hsa-miR-3916 hsa-miR-4267 hsa-miR-890 hsa-miR-208b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SHISA6
    Predesigned siRNA for gene silencing in human, mouse, rat SHISA6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SHISA6

    Clone
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    OriGene clones in human, mouse for SHISA6 (see all 17)
    OriGene ORF clones in mouse, rat for SHISA6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SHISA6 (NM_207386)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SHISA6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHISA6

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SHISA6
    Browse ESI BIO Cell Lines and PureStem Progenitors for SHISA6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHISA6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SHSA6_HUMAN, Q6ZSJ9: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032281alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex IEA--

    SHISA6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SHISA6
    Interactions:

        Search GeneGlobe Interaction Network for SHISA6

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SHISA6 (SHSA6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SHISA6 gene (4 alternative transcripts): 
    NM_175903.2  NM_001173461.1  NM_001173462.1  NM_207386.3  

    Unigene Cluster for SHISA6:

    Shisa homolog 6 (Xenopus laevis)
    Hs.592124  [show with all ESTs]
    Unigene Representative Sequence: NM_207386
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000441885(uc002gnc.2) ENST00000432116(uc010com.3) ENST00000409168(uc002gna.4 uc010con.3)
    ENST00000343478
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SHISA6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SHISA6 (see all 103):
    hsa-miR-194* hsa-miR-4254 hsa-miR-128 hsa-miR-374a hsa-miR-3916 hsa-miR-4267 hsa-miR-890 hsa-miR-208b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SHISA6
    Predesigned siRNA for gene silencing in human, mouse, rat SHISA6
    Clone
    Products:
         
    OriGene clones in human, mouse for SHISA6 (see all 17)
    OriGene ORF clones in mouse, rat for SHISA6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SHISA6 (NM_207386)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SHISA6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHISA6
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SHISA6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SHISA6
      QuantiTect SYBR Green Assays in human, mouse, rat SHISA6
      QuantiFast Probe-based Assays in human, mouse, rat SHISA6

    Additional mRNA sequence: 

    AK094349.1 AK095052.1 AK127379.1 AK128003.1 BC105704.1 BC105705.1 BC105706.1 BC105707.1 
    DQ070854.1 

    6 DOTS entries:

    DT.92043545  DT.101976590  DT.101976589  DT.441340  DT.120996616  DT.40289368 

    10 AceView cDNA sequences:

    AK128003 AK127379 AA460977 NM_207386 AI370640 AA441990 AI126777 BX109938 
    R46311 AA461286 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SHISA6    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:                                          
    SP2:                    -                     
    SP3:              -     -                     


    ECgene alternative splicing isoforms for SHISA6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SHISA6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTGTAAAC
    SHISA6 Expression
    About this image


    SHISA6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Brain (Nervous System)
             Oligodendrocyte Precursor Cells Forebrain White Matter
    SHISA6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SHISA6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592124

    UniProtKB/Swiss-Prot: SHSA6_HUMAN, Q6ZSJ9
    Tissue specificity: Expressed in the developing ventral mesencephalon

        Custom PCR Arrays for SHISA6
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SHISA6
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    QuantiFast Probe-based Assays in human, mouse, rat SHISA6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHISA6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SHISA6 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Shisa61 , 5 shisa homolog 6 (Xenopus laevis)1, 5 89.4(n)1
    95.37(a)1
      11 (40.55 cM)5
    3807021  NM_001034874.31  NP_001030046.11 
     662117255 
    chicken
    (Gallus gallus)
    Aves SHISA61 shisa homolog 6 (Xenopus laevis) 78.22(n)
    80.16(a)
      768703  XM_001231790.3  XP_001231791.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    82(a)
    1 → many
    2(104100647-104276605)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia shisa61 shisa family member 6 70.09(n)
    73.5(a)
      779586  XM_004918408.1  XP_004918465.1 
    zebrafish
    (Danio rerio)
    Actinopterygii SHISA6 (3 of 3)6
    CABZ01100326.16
    (see all 3)
    Uncharacterized protein
    (see all 3)
    48(a)
    47(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    Zv9_NA325(4968-20747) ENSDARG00000089298
    12(123321-124786) ENSDARG00000087598


    ENSEMBL Gene Tree for SHISA6 (if available)
    TreeFam Gene Tree for SHISA6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SHISA6 gene
    SHISA82  SHISA72  SHISA92  
    1 SIMAP similar gene for SHISA6 using alignment to 2 protein entries:     SHSA6_HUMAN (see all proteins):
    SHISA9

    SHISA6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SHISA6 (see all 7187)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1842738891,2
    C--11044183(+) AGAAGA/GTGGCA 3 -- int10--------
    rs755670681,2
    C,F--11044230(+) AAGAGG/AGAGGG 3 -- int11Minor allele frequency- A:0.01WA 118
    rs1511994781,2
    --11044243(+) TGGAGA/TCAGTA 3 -- int10--------
    rs116530551,2
    C,F,H--11044247(+) GACAGC/TAGCAA 3 -- int128Minor allele frequency- T:0.37NS EA NA WA CSA 2772
    rs732917981,2
    C,F--11143032(+) GCCTCG/ATAGCT 3 -- us2k12Minor allele frequency- A:0.21WA 120
    rs1892236421,2
    --11143423(+) TTTGAC/TCTCTT 3 -- us2k10--------
    rs65033621,2
    C,F,A,H--11143493(+) CGCTCT/AGGCAG 3 -- us2k116Minor allele frequency- A:0.27NS EA NA WA CSA 791
    rs1403258091,2
    --11143506(+) CGCTGC/TCCCGG 3 -- us2k10--------
    rs1455645441,2
    --11143617(+) GCTCCC/GGGCCC 3 -- us2k10--------
    rs732918001,2
    C--11143670(+) CGGAGC/TTTTCG 3 -- us2k12Minor allele frequency- T:0.10WA 120

    HapMap Linkage Disequilibrium report for SHISA6 (11144580 - 11394580 bp, first 250kb of SHISA6)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SHISA6 (see all 31):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715647CNV Deletion23290073
    esv2674601CNV Deletion23128226
    esv2073057CNV Deletion18987734
    esv2715644CNV Deletion23290073
    esv2715645CNV Deletion23290073
    esv1972844CNV Deletion18987734
    esv2715646CNV Deletion23290073
    esv2715648CNV Deletion23290073
    nsv820333CNV Deletion20802225
    esv2715649CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SHISA6
    DNA2.0 Custom Variant and Variant Library Synthesis for SHISA6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    4 diseases for SHISA6:    
    About MalaCards
    refractive error    myopia    type 1 diabetes    obesity


    SHISA6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SHISA6
    Human Genome Epidemiology (HuGE) Navigator: SHISA6 (1 document)

    Export disorders for SHISA6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SHISA6 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with SHISA6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
    4. Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. (PubMed id 23396134)1 Verhoeven V.J....Hammond C.J. (Nat. Genet. 2013)
    5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    6. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614)4 Paterson A.D....Bull S.B. (Diabetes 2010)
    7. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)
    10. Identification of novel genes regulated in the developing human ventral mesencephalon. (PubMed id 16473350)2 Joergensen J.R.... Wahlberg L.U. (Exp. Neurol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 388336 HGNC: 34491 AceView: FLJ45455 Ensembl:ENSG00000188803 euGenes: HUgn388336
    ECgene: SHISA6 H-InvDB: SHISA6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SHISA6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SHISA6 gene:
    Search GeneIP for patents involving SHISA6

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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