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Aliases for SHISA6 Gene

Aliases for SHISA6 Gene

  • Shisa Family Member 6 2 3 5
  • Shisa Homolog 6 (Xenopus Laevis) 2

External Ids for SHISA6 Gene

Previous GeneCards Identifiers for SHISA6 Gene

  • GC17P011086
  • GC17P011046
  • GC17P011144

Summaries for SHISA6 Gene

GeneCards Summary for SHISA6 Gene

SHISA6 (Shisa Family Member 6) is a Protein Coding gene. Diseases associated with SHISA6 include Refractive Error. An important paralog of this gene is SHISA7.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHISA6 Gene

Genomics for SHISA6 Gene

Regulatory Elements for SHISA6 Gene

Enhancers for SHISA6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F010768 0.4 FANTOM5 3.4 -472.2 -472183 0.3 RNU6-1065P RPL15P21 MYH3 SCO1 ADPRM PIRT SHISA6 MYH4 ENSG00000264016 GC17M010769
GH17F010754 1.4 FANTOM5 Ensembl ENCODE 1.8 -484.5 -484549 3.9 SOX13 ARID4B RAD21 RARA YY1 E2F1 GATA3 CTBP1 POLR2A ZNF366 ADPRM TMEM220-AS1 ENSG00000264016 TMEM220 PIRT SHISA6 GC17M010753 ENSG00000240813
GH17F011221 0.5 ENCODE 0.3 -19.3 -19275 0.1 SHISA6 RN7SL601P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SHISA6 on UCSC Golden Path with GeneCards custom track

Genomic Location for SHISA6 Gene

Chromosome:
17
Start:
11,241,263 bp from pter
End:
11,564,063 bp from pter
Size:
322,801 bases
Orientation:
Plus strand

Genomic View for SHISA6 Gene

Genes around SHISA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHISA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHISA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHISA6 Gene

Proteins for SHISA6 Gene

  • Protein details for SHISA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZSJ9-SHSA6_HUMAN
    Recommended name:
    Protein shisa-6 homolog
    Protein Accession:
    Q6ZSJ9
    Secondary Accessions:
    • B3KXV5
    • Q4PL63

    Protein attributes for SHISA6 Gene

    Size:
    500 amino acids
    Molecular mass:
    55764 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86949.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG54617.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SHISA6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SHISA6 Gene

Post-translational modifications for SHISA6 Gene

  • Glycosylation at Asn 32 and Asn 59
  • Modification sites at PhosphoSitePlus

Other Protein References for SHISA6 Gene

No data available for DME Specific Peptides for SHISA6 Gene

Domains & Families for SHISA6 Gene

Gene Families for SHISA6 Gene

Protein Domains for SHISA6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SHISA6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZSJ9

UniProtKB/Swiss-Prot:

SHSA6_HUMAN :
  • Belongs to the shisa family.
Family:
  • Belongs to the shisa family.
genes like me logo Genes that share domains with SHISA6: view

Function for SHISA6 Gene

genes like me logo Genes that share phenotypes with SHISA6: view

Animal Model Products

miRNA for SHISA6 Gene

miRTarBase miRNAs that target SHISA6

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SHISA6 Gene

Localization for SHISA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHISA6 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SHISA6 Gene COMPARTMENTS Subcellular localization image for SHISA6 gene
Compartment Confidence
plasma membrane 4
extracellular 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SHISA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0032281 AMPA glutamate receptor complex IBA --
GO:0045202 synapse IBA --
genes like me logo Genes that share ontologies with SHISA6: view

Pathways & Interactions for SHISA6 Gene

SuperPathways for SHISA6 Gene

No Data Available

Interacting Proteins for SHISA6 Gene

Gene Ontology (GO) - Biological Process for SHISA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048172 regulation of short-term neuronal synaptic plasticity IBA --
genes like me logo Genes that share ontologies with SHISA6: view

No data available for Pathways by source and SIGNOR curated interactions for SHISA6 Gene

Transcripts for SHISA6 Gene

mRNA/cDNA for SHISA6 Gene

(5) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SHISA6 Gene

Shisa homolog 6 (Xenopus laevis):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHISA6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -
SP3: - -

Relevant External Links for SHISA6 Gene

GeneLoc Exon Structure for
SHISA6
ECgene alternative splicing isoforms for
SHISA6

Expression for SHISA6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SHISA6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SHISA6 Gene

This gene is overexpressed in Brain - Hippocampus (x7.5), Brain - Cerebellum (x5.5), and Brain - Spinal cord (cervical c-1) (x4.2).

Protein differential expression in normal tissues from HIPED for SHISA6 Gene

This gene is overexpressed in Platelet (31.3), Tlymphocyte (28.5), and Heart (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SHISA6 Gene



Protein tissue co-expression partners for SHISA6 Gene

NURSA nuclear receptor signaling pathways regulating expression of SHISA6 Gene:

SHISA6

SOURCE GeneReport for Unigene cluster for SHISA6 Gene:

Hs.592124

mRNA Expression by UniProt/SwissProt for SHISA6 Gene:

Q6ZSJ9-SHSA6_HUMAN
Tissue specificity: Expressed in the developing ventral mesencephalon.
genes like me logo Genes that share expression patterns with SHISA6: view

Primer Products

Orthologs for SHISA6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SHISA6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SHISA6 34 35
  • 99.06 (n)
cow
(Bos Taurus)
Mammalia SHISA6 34
  • 93.13 (n)
dog
(Canis familiaris)
Mammalia SHISA6 35
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Shisa6 34
  • 89.45 (n)
mouse
(Mus musculus)
Mammalia Shisa6 34 16 35
  • 89.4 (n)
oppossum
(Monodelphis domestica)
Mammalia SHISA6 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SHISA6 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves SHISA6 34 35
  • 78.22 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 82 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia shisa6 34
  • 70.09 (n)
zebrafish
(Danio rerio)
Actinopterygii SHISA6 (3 of 3) 35
  • 48 (a)
OneToMany
CABZ01100326.1 35
  • 47 (a)
OneToMany
SHISA6 (1 of 3) 35
  • 47 (a)
OneToMany
Species where no ortholog for SHISA6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHISA6 Gene

ENSEMBL:
Gene Tree for SHISA6 (if available)
TreeFam:
Gene Tree for SHISA6 (if available)

Paralogs for SHISA6 Gene

Paralogs for SHISA6 Gene

(1) SIMAP similar genes for SHISA6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SHISA6: view

Variants for SHISA6 Gene

Sequence variations from dbSNP and Humsavar for SHISA6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1003882 -- 11,268,422(+) cctcc(C/T)aggct intron-variant
rs1003883 -- 11,268,496(+) AGATA(C/T)TTCCC intron-variant
rs1006233 -- 11,466,039(+) GTTCT(C/T)CTAGA intron-variant
rs1006234 -- 11,466,228(+) AGAGA(A/G)CACAC intron-variant
rs1008360 -- 11,306,475(+) GTTCC(A/G)CTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SHISA6 Gene

Variant ID Type Subtype PubMed ID
dgv5447n54 CNV loss 21841781
esv1972844 CNV deletion 18987734
esv2073057 CNV deletion 18987734
esv22264 CNV gain 19812545
esv22543 CNV gain+loss 19812545
esv22761 CNV loss 19812545
esv25916 CNV gain 19812545
esv2674601 CNV deletion 23128226
esv2715644 CNV deletion 23290073
esv2715645 CNV deletion 23290073
esv2715646 CNV deletion 23290073
esv2715647 CNV deletion 23290073
esv2715648 CNV deletion 23290073
esv2715649 CNV deletion 23290073
esv3310241 CNV mobile element insertion 20981092
esv33600 CNV gain 17666407
esv3447953 CNV insertion 20981092
esv3554136 CNV deletion 23714750
esv3554139 CNV deletion 23714750
esv3639951 CNV gain 21293372
esv3639952 CNV loss 21293372
esv3639953 CNV loss 21293372
esv3639954 CNV loss 21293372
nsv1057473 CNV gain 25217958
nsv1070809 CNV deletion 25765185
nsv1070810 CNV deletion 25765185
nsv112054 CNV insertion 16902084
nsv1134599 CNV deletion 24896259
nsv1136228 CNV deletion 24896259
nsv154 CNV deletion 15895083
nsv1980 CNV deletion 18451855
nsv1981 CNV deletion 18451855
nsv433304 CNV loss 18776910
nsv457669 CNV loss 19166990
nsv457670 CNV loss 19166990
nsv472126 CNV novel sequence insertion 20440878
nsv475317 CNV novel sequence insertion 20440878
nsv483036 CNV loss 15286789
nsv498868 CNV loss 21111241
nsv510698 CNV deletion 20534489
nsv518545 CNV gain 19592680
nsv519168 CNV loss 19592680
nsv523923 CNV loss 19592680
nsv526919 CNV loss 19592680
nsv574359 CNV loss 21841781
nsv574360 CNV loss 21841781
nsv574361 CNV loss 21841781
nsv574362 CNV loss 21841781
nsv574363 CNV loss 21841781
nsv574369 CNV loss 21841781
nsv820333 CNV deletion 20802225
nsv833371 CNV gain 17160897
nsv953830 CNV deletion 24416366

Variation tolerance for SHISA6 Gene

Gene Damage Index Score: 2.41; 42.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SHISA6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SHISA6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHISA6 Gene

Disorders for SHISA6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SHISA6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
refractive error
  • refractive errors
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SHISA6

Genetic Association Database (GAD)
SHISA6
Human Genome Epidemiology (HuGE) Navigator
SHISA6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SHISA6
genes like me logo Genes that share disorders with SHISA6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SHISA6 Gene

Publications for SHISA6 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. (PMID: 24262325) Dichgans M. … . (Stroke 2014) 3 64
  4. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3 64
  5. Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. (PMID: 23396134) Verhoeven V.J. … Hammond C.J. (Nat. Genet. 2013) 3 64

Products for SHISA6 Gene

Sources for SHISA6 Gene

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