Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SHISA6 Gene

Aliases for SHISA6 Gene

  • Shisa Family Member 6 2 3
  • Shisa Homolog 6 (Xenopus Laevis) 2

External Ids for SHISA6 Gene

Previous GeneCards Identifiers for SHISA6 Gene

  • GC17P011086
  • GC17P011046
  • GC17P011144

Summaries for SHISA6 Gene

GeneCards Summary for SHISA6 Gene

SHISA6 (Shisa Family Member 6) is a Protein Coding gene. An important paralog of this gene is SHISA8.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHISA6 Gene

Genomics for SHISA6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SHISA6 Gene

11,241,263 bp from pter
11,564,063 bp from pter
322,801 bases
Plus strand

Genomic View for SHISA6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SHISA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHISA6 Gene

No data available for Regulatory Elements for SHISA6 Gene

Proteins for SHISA6 Gene

  • Protein details for SHISA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein shisa-6 homolog
    Protein Accession:
    Secondary Accessions:
    • B3KXV5
    • Q4PL63

    Protein attributes for SHISA6 Gene

    500 amino acids
    Molecular mass:
    55764 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC86949.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG54617.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SHISA6 Gene


neXtProt entry for SHISA6 Gene

Proteomics data for SHISA6 Gene at MOPED

Post-translational modifications for SHISA6 Gene

  • Glycosylation at Asn32 and Asn59
  • Modification sites at PhosphoSitePlus

Other Protein References for SHISA6 Gene

No data available for DME Specific Peptides for SHISA6 Gene

Domains for SHISA6 Gene

Gene Families for SHISA6 Gene

Protein Domains for SHISA6 Gene


Suggested Antigen Peptide Sequences for SHISA6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the shisa family.
  • Belongs to the shisa family.
genes like me logo Genes that share domains with SHISA6: view

Function for SHISA6 Gene

Phenotypes for SHISA6 Gene

GenomeRNAi human phenotypes for SHISA6:
genes like me logo Genes that share phenotypes with SHISA6: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SHISA6

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SHISA6 Gene

Localization for SHISA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHISA6 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for SHISA6 Gene COMPARTMENTS Subcellular localization image for SHISA6 gene
Compartment Confidence
extracellular 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SHISA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex IEA --
genes like me logo Genes that share ontologies with SHISA6: view

Pathways for SHISA6 Gene

SuperPathways for SHISA6 Gene

No Data Available

Interacting Proteins for SHISA6 Gene

Gene Ontology (GO) - Biological Process for SHISA6 Gene


No data available for Pathways by source for SHISA6 Gene

Transcripts for SHISA6 Gene

mRNA/cDNA for SHISA6 Gene

Unigene Clusters for SHISA6 Gene

Shisa homolog 6 (Xenopus laevis):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SHISA6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHISA6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP2: -
SP3: - -

Relevant External Links for SHISA6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SHISA6 Gene

mRNA expression in normal human tissues for SHISA6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SHISA6 Gene

This gene is overexpressed in Brain - Hippocampus (7.5), Brain - Cerebellum (5.5), and Brain - Spinal cord (cervical c-1) (4.2).

Protein differential expression in normal tissues for SHISA6 Gene

This gene is overexpressed in Platelet (31.3), Tlymphocyte (28.5), and Heart (8.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SHISA6 Gene

SOURCE GeneReport for Unigene cluster for SHISA6 Gene Hs.592124

mRNA Expression by UniProt/SwissProt for SHISA6 Gene

Tissue specificity: Expressed in the developing ventral mesencephalon.
genes like me logo Genes that share expressions with SHISA6: view

Expression partners for SHISA6 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for SHISA6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SHISA6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SHISA6 35
  • 93.13 (n)
  • 95.23 (a)
(Mus musculus)
Mammalia Shisa6 35
  • 89.4 (n)
  • 95.37 (a)
Shisa6 16
Shisa6 36
  • 83 (a)
(Pan troglodytes)
Mammalia SHISA6 35
  • 99.06 (n)
  • 99.06 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Shisa6 35
  • 89.45 (n)
  • 95.16 (a)
(Canis familiaris)
Mammalia SHISA6 36
  • 93 (a)
(Monodelphis domestica)
Mammalia SHISA6 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia SHISA6 36
  • 69 (a)
(Gallus gallus)
Aves SHISA6 35
  • 78.22 (n)
  • 80.16 (a)
  • 84 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia shisa6 35
  • 70.09 (n)
  • 73.5 (a)
(Danio rerio)
Actinopterygii CABZ01100326.1 36
  • 47 (a)
SHISA6 (1 of 3) 36
  • 47 (a)
SHISA6 (3 of 3) 36
  • 48 (a)
Species with no ortholog for SHISA6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHISA6 Gene

Gene Tree for SHISA6 (if available)
Gene Tree for SHISA6 (if available)

Paralogs for SHISA6 Gene

Paralogs for SHISA6 Gene

(1) SIMAP similar genes for SHISA6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SHISA6: view

Variants for SHISA6 Gene

Sequence variations from dbSNP and Humsavar for SHISA6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs9227 -- 11,563,878(-) CATGA(A/G)GCTTA utr-variant-3-prime
rs16722 -- 11,448,229(-) AAAGA(-/ACAA)TTAAG intron-variant
rs118458 -- 11,373,173(+) CTTGG(C/T)GGATT intron-variant
rs169505 -- 11,329,387(+) TGCAT(A/G)GGGGT intron-variant
rs169506 -- 11,329,612(+) TTTTA(A/G)GTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SHISA6 Gene

Variant ID Type Subtype PubMed ID
nsv457669 CNV Loss 19166990
nsv112054 CNV Insertion 16902084
nsv833371 CNV Gain 17160897
esv25916 CNV Gain 19812545
nsv523923 CNV Loss 19592680
nsv457670 CNV Loss 19166990
esv274513 CNV Insertion 20981092
nsv154 CNV Loss 15895083
nsv1980 CNV Loss 18451855
nsv518545 CNV Gain 19592680
nsv519168 CNV Loss 19592680
nsv526919 CNV Loss 19592680
nsv510698 CNV Loss 20534489
nsv498868 CNV Loss 21111241
esv22761 CNV Loss 19812545
nsv433304 CNV Loss 18776910
esv33600 CNV Gain 17666407
esv22264 CNV Gain 19812545
esv2715644 CNV Deletion 23290073
esv2715645 CNV Deletion 23290073
esv1972844 CNV Deletion 18987734
esv2715646 CNV Deletion 23290073
nsv1981 CNV Loss 18451855
esv22543 CNV Gain+Loss 19812545
nsv820333 CNV Deletion 20802225
esv2715647 CNV Deletion 23290073
esv2674601 CNV Deletion 23128226
esv2715648 CNV Deletion 23290073
esv2073057 CNV Deletion 18987734
esv2715649 CNV Deletion 23290073
nsv907688 CNV Gain 21882294

Relevant External Links for SHISA6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHISA6 Gene

Disorders for SHISA6 Gene

Relevant External Links for SHISA6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for SHISA6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SHISA6 Gene

Publications for SHISA6 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3

Products for SHISA6 Gene

Sources for SHISA6 Gene

Back to Top