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SHISA5 Gene

protein-coding   GIFtS: 51
GCID: GC03M048485

Shisa Family Member 5

(Previous name: shisa homolog 5 (Xenopus laevis))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Shisa Family Member 51 2     Protein Shisa-52
SCOTIN2 3 5     Shisa Homolog 52
Putative NF-Kappa-B-Activating Protein 1202 3     Scotin3
Shisa Homolog 5 (Xenopus Laevis)1     

External Ids:    HGNC: 303761   Entrez Gene: 512462   Ensembl: ENSG000001640547   OMIM: 6072905   UniProtKB: Q8N1143   
ORGUL members:         

Export aliases for SHISA5 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SHISA5 Gene:
This gene encodes a member of the shisa family. The encoded protein is localized to the endoplasmic reticulum, and
together with p53 induces apoptosis in a caspase-dependent manner. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Jan 2013)

GeneCards Summary for SHISA5 Gene:
SHISA5 (shisa family member 5) is a protein-coding gene. Diseases associated with SHISA5 include pandas, and neuroblastoma. GO annotations related to this gene include WW domain binding and signal transducer activity.

UniProtKB/Swiss-Prot: SHSA5_HUMAN, Q8N114
Function: Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SHISA5 gene promoter:
         COUP-TF1   COUP   AP-4   HNF-4alpha2   E47   HNF-4alpha1   POU2F1   COUP-TF   COMP1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SHISA5 promoter sequence
   Search Chromatin IP Primers for SHISA5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SHISA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

SHISA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHISA5 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M048485:  view genomic region     (about GC identifiers)

Start:
48,509,197 bp from pter      End:
48,542,259 bp from pter
Size:
33,063 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SHSA5_HUMAN, Q8N114 (See protein sequence)
Recommended Name: Protein shisa-5 precursor  
Size: 240 amino acids; 25582 Da
Subunit: Interacts with PDCD6; PDCD6 can stabilze SHISA5
Secondary accessions: B3KW99 Q69YY9 Q7Z433 Q8NHL9 Q96MW8 Q9BV58
Alternative splicing: 4 isoforms:  Q8N114-1   Q8N114-2   Q8N114-3   Q8N114-4   

Explore the universe of human proteins at neXtProt for SHISA5: NX_Q8N114

Explore proteomics data for SHISA5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SHISA5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001258994.1  NP_001258995.1  NP_001258996.1  NP_001258997.1  NP_001259011.1  NP_001259012.1  NP_057563.3  

    ENSEMBL proteins: 
     ENSP00000296444   ENSP00000407957   ENSP00000390388   ENSP00000407330   ENSP00000408223  
     ENSP00000395373   ENSP00000412811   ENSP00000412509   ENSP00000400498   ENSP00000415097  

    SHISA5 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SHISA5
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SHISA5
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    Novus Biologicals SHISA5 Protein
    Novus Biologicals SHISA5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SHISA5

    SHISA5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Custom Antibody Services for SHISA5
    Novus Biologicals SHISA5 Antibodies
    Search for Antibodies for SHISA5 at Abcam
    Cloud-Clone Corp. Antibodies for SHISA5
    Search ThermoFisher Antibodies for SHISA5
    LSBio Antibodies in human, mouse, rat for SHISA5

    SHISA5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for SHISA5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SHISA5
    Cloud-Clone Corp. CLIAs for SHISA5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SHISA: Shisa homologs

    1 InterPro protein domain:
     IPR026910 Shisa

    Graphical View of Domain Structure for InterPro Entry Q8N114

    ProtoNet protein and cluster: Q8N114

    UniProtKB/Swiss-Prot: SHSA5_HUMAN, Q8N114
    Domain: The proline-rich region is required for endoplasmic reticulum localization
    Similarity: Belongs to the shisa family


    SHISA5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SHSA5_HUMAN, Q8N114
    Function: Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis
    Induction: Induced in a p53/TP53-dependent manner in response to cellular stress

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP12761501
    GO:0005515protein binding IPI15064722
    GO:0050699WW domain binding IPI15064722
         
    SHISA5 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Shisa5):
     normal 

    SHISA5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Shisa5tm1Sia for SHISA5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SHISA5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SHISA5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SHISA5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SHISA5

    miRNA
    Products:
        
    miRTarBase miRNAs that target SHISA5:
    hsa-mir-7-5p (MIRT025901), hsa-mir-92a-3p (MIRT048940), hsa-mir-1296-5p (MIRT036083), hsa-mir-877-5p (MIRT037247)

    Block miRNA regulation of human, mouse, rat SHISA5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SHISA5 (see all 14):
    hsa-miR-485-5p hsa-miR-198 hsa-miR-202 hsa-miR-509-5p hsa-miR-1324 hsa-miR-133b hsa-miR-1205 hsa-miR-33a
    SwitchGear 3'UTR luciferase reporter plasmidSHISA5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SHISA5
    Predesigned siRNA for gene silencing in human, mouse, rat SHISA5

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for SHISA5 (see all 7)
    OriGene ORF clones in mouse, rat for SHISA5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SHISA5 (NM_016479)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SHISA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHISA5

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SHISA5
    Browse ESI BIO Cell Lines and PureStem Progenitors for SHISA5 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHISA5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SHSA5_HUMAN, Q8N114: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus5
    extracellular2
    plasma membrane2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope ----
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0031965nuclear membrane IEA--

    SHISA5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SHISA5 About    
    See pathways by source

    SuperPathContained pathways About
    1p53 signaling pathway
    p53 signaling pathway0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for SHISA5):
        p53 signaling pathway


    SHISA5 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SHISA5
    Interactions:

        Search GeneGlobe Interaction Network for SHISA5

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for SHISA5 (Q8N1141, 3 ENSP000002964444) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS5Q929053, ENSP000003505124I2D: score=2 STRING: ENSP00000350512
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    WWOXQ9NZC71EBI-2115556,EBI-4320739
    ALG2ENSP000004177644STRING: ENSP00000417764
    -P12815-11EBI-2115556,EBI-6903105
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process ----
    GO:0007165signal transduction ----
    GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA--
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling IMP12761501
    GO:0072332intrinsic apoptotic signaling pathway by p53 class mediator ----

    SHISA5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SHISA5 (SHSA5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SHISA5 gene (7 alternative transcripts): 
    NM_001272065.1  NM_001272066.1  NM_001272067.1  NM_001272068.1  NM_001272082.1  NM_001272083.1  NM_016479.4  

    Unigene Cluster for SHISA5:

    Shisa homolog 5 (Xenopus laevis)
    Hs.414579  [show with all ESTs]
    Unigene Representative Sequence: NM_001272068
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296444(uc011bbl.2 uc003ctp.1) ENST00000444115 ENST00000466424
    ENST00000494854(uc003ctt.3) ENST00000426002(uc003ctm.2) ENST00000465449(uc011bbk.1)
    ENST00000417962(uc003cto.1) ENST00000442747(uc003cts.1) ENST00000443308
    ENST00000460758 ENST00000497863 ENST00000486344 ENST00000424965 ENST00000417841
    ENST00000415268 ENST00000441507 ENST00000490864 ENST00000496408
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SHISA5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SHISA5 (see all 14):
    hsa-miR-485-5p hsa-miR-198 hsa-miR-202 hsa-miR-509-5p hsa-miR-1324 hsa-miR-133b hsa-miR-1205 hsa-miR-33a
    SwitchGear 3'UTR luciferase reporter plasmidSHISA5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SHISA5
    Predesigned siRNA for gene silencing in human, mouse, rat SHISA5
    Clone
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    OriGene clones in human, mouse for SHISA5 (see all 7)
    OriGene ORF clones in mouse, rat for SHISA5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SHISA5 (NM_016479)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SHISA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHISA5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SHISA5
    OriGene qSTAR qPCR primer pairs in human, mouse for SHISA5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SHISA5
      QuantiTect SYBR Green Assays in human, mouse, rat SHISA5
      QuantiFast Probe-based Assays in human, mouse, rat SHISA5

    Additional mRNA sequence: 

    AB097007.1 AF151051.1 AF520698.1 AK027728.1 AK056328.1 AK075441.1 AK124652.1 AK298799.1 
    AK298842.1 AK301191.1 AK310083.1 AL117413.1 AL832568.1 BC001463.2 BC020279.2 

    Selected DOTS entries (see all 68):

    DT.95199575  DT.455173  DT.100848035  DT.92458393  DT.120905984  DT.120906226  DT.120906219  DT.120906058 
    DT.95305137  DT.95199572  DT.100691304  DT.100691328  DT.100847497  DT.95199563  DT.95199576  DT.100691310 
    DT.100691306  DT.100857524  DT.95199562  DT.100640671  DT.100691302  DT.120906289  DT.120906258  DT.97868511 

    Selected AceView cDNA sequences (see all 82):

    BM924007 CA454469 BU508967 CR617624 BM920145 BU539543 CR619483 NM_016479 
    CR604587 T08246 CB118910 AF520698 CR623835 BM705194 BQ959287 AK075441 
    BX336842 CR615636 BX351936 BX334804 BU527101 AK056328 BI833964 CR595213 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SHISA5 (see all 23)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^
    SP1:                                                        -     -     -                       -     -           -     -     -     -     -     -     -     -   
    SP2:                                            -     -     -     -     -                       -     -           -     -     -     -     -     -     -     -   
    SP3:                                            -     -     -     -     -                 -     -     -           -     -     -     -     -     -     -     -   
    SP4:                    -     -     -     -     -     -     -     -     -                       -     -           -     -     -     -     -     -     -     -   
    SP5:                                            -     -     -     -     -                       -     -                 -     -     -     -     -     -     -   

    ExUns: 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d · 13e · 13f · 13g · 13h ^ 14a · 14b · 14c
    SP1:        -                       -                                                                     
    SP2:        -                       -                                                                     
    SP3:        -                       -                                                                     
    SP4:        -                                                                                             
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for SHISA5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SHISA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATACCTCGT
    SHISA5 Expression
    About this image

    SHISA5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SHISA5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.414579
        Custom PCR Arrays for SHISA5
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SHISA5
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    QuantiFast Probe-based Assays in human, mouse, rat SHISA5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHISA5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SHISA5 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Shisa51 , 5 shisa homolog 5 (Xenopus laevis)1, 5 74.67(n)1
    67.11(a)1
      9 (59.63 cM)5
    669401  NM_001284332.11  NP_001271261.11 
     1090385655 
    chicken
    (Gallus gallus)
    Aves SHISA56
    Gallus gallus shisa homolog 5 (Xenopus laevis) (SH...
    69(a)
    1 ↔ 1
    12(3242719-3253873)
    lizard
    (Anolis carolinensis)
    Reptilia SHISA56
    shisa family member 5
    50(a)
    1 ↔ 1
    2(155879949-155915544)


    ENSEMBL Gene Tree for SHISA5 (if available)
    TreeFam Gene Tree for SHISA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SHISA5 (see all 838)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2010686401,2
    --48439724(+) TGCTGC/TGGTGG 7 -- ds50010--------
    rs1392280691,2
    C--48439753(+) CCTTTC/GGGCAC 7 -- ds50011Minor allele frequency- G:0.00NA 4548
    rs1131077331,2
    C,F--48439754(+) CTTTCG/AGCACC 7 -- ds50012Minor allele frequency- A:0.00CSA NA 4548
    rs725565551,2
    C,F--48439795(+) GCTAGG/CACCAA 7 -- ds50016Minor allele frequency- C:0.00MN NA 4958
    rs1127419621,2
    C,F--48439814(+) CATCTG/CCTGTC 7 -- ds50012Minor allele frequency- C:0.00CSA NA 4548
    rs2015034091,2
    --48439815(+) ATCTGC/TTGTCA 7 -- ds50010--------
    rs559999871,2
    C,F--48439872(+) TGGAGA/GGAGCA 7 -- ds50012Minor allele frequency- G:0.00NA EU 5869
    rs2007193011,2
    --48439918(+) GGAGCC/TCTATC 7 -- ds50010--------
    rs31359451,2
    C,F,H--48439987(+) ACACTG/ATATGG 7 -- ds500121Minor allele frequency- A:0.05NS EA NA WA CSA EU 7797
    rs31359461,2
    C,F,A,H--48440057(+) CCCGCT/CGCCCC 7 -- ds500111Minor allele frequency- C:0.06NS NA CSA WA EU 2400

    HapMap Linkage Disequilibrium report for SHISA5 (48509197 - 48542259 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for SHISA5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3809CNV Insertion18451855
    esv992291CNV Insertion20482838
    esv1621474CNV Insertion17803354
    esv996619CNV Insertion20482838
    esv1539272CNV Insertion17803354
    esv2635148CNV Insertion19546169
    nsv508917CNV Insertion20534489
    esv1400295CNV Insertion17803354
    nsv523981CNV Loss19592680
    nsv834684CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607290    OMIM disorders: --

    4 diseases for SHISA5:    
    About MalaCards
    pandas    neuroblastoma    schizophrenia    squamous cell carcinoma


    SHISA5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SHISA5
    Human Genome Epidemiology (HuGE) Navigator: SHISA5 (1 document)

    Export disorders for SHISA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SHISA5 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with SHISA5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane. (PubMed id 12135983)1, 2, 3 Bourdon J.-C.... Lane D.P. (J. Cell Biol. 2002)
    2. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    3. The calcium binding protein ALG-2 binds and stabilizes Scotin, a p53-inducible gene product localized at the endoplasmic reticulum membrane. (PubMed id 17889823)1, 2 Draeby I....Berchtold M.W. (Arch. Biochem. Biophys. 2007)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 2 Matsuda A....Sugano S. (Oncogene 2003)
    6. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    7. Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. (PubMed id 18624398)1 Wang J....He F. (J. Proteome Res. 2008)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. (PubMed id 15064722)1 Ludes-Meyers J.H....Aldaz C.M. (Oncogene 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51246 HGNC: 30376 AceView: FLJ12436.1 Ensembl:ENSG00000164054 euGenes: HUgn51246
    ECgene: SHISA5 Kegg: 51246 H-InvDB: SHISA5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SHISA5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SHISA5 gene:
    Search GeneIP for patents involving SHISA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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