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Aliases for SHISA4 Gene

Aliases for SHISA4 Gene

  • Shisa Family Member 4 2 3 5
  • Transmembrane Protein 58 2 3 4
  • C1orf40 3 4
  • TMEM58 3 4
  • Chromosome 1 Open Reading Frame 40 2
  • Shisa Homolog 4 (Xenopus Laevis) 2
  • Protein Shisa-4 3
  • Shisa Homolog 4 3

External Ids for SHISA4 Gene

Previous HGNC Symbols for SHISA4 Gene

  • C1orf40
  • TMEM58

Previous GeneCards Identifiers for SHISA4 Gene

  • GC01P200126
  • GC01P201857
  • GC01P173023

Summaries for SHISA4 Gene

GeneCards Summary for SHISA4 Gene

SHISA4 (Shisa Family Member 4) is a Protein Coding gene.

Additional gene information for SHISA4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHISA4 Gene

Genomics for SHISA4 Gene

Regulatory Elements for SHISA4 Gene

Enhancers for SHISA4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H201911 1.8 FANTOM5 Ensembl ENCODE dbSUPER 55.2 +26.9 26920 7.6 ATF1 FOXA2 FEZF1 ZNF766 GLIS2 GATA2 ELK1 ATF7 FOS DEK SHISA4 LMOD1 IPO9-AS1 ENSG00000223774 SNORA70H RPL10P4 RNPEP IPO9 TIMM17A ENSG00000235121
GH01H201881 1.5 Ensembl ENCODE dbSUPER 44.2 -3.0 -2953 8.1 HDGF ATF1 SIN3A YY1 GLIS2 FOS ATF7 NCOA1 SMARCB1 ZNF592 SHISA4 LMOD1 PPP1R12B GC01M201880 GC01M201879
GH01H201902 1.1 Ensembl ENCODE dbSUPER 43.5 +17.0 17043 7.1 CEBPB MAX CEBPG NR2F2 YY1 JUND CTBP1 POLR2A HNF4A SHISA4 LMOD1 GC01M201886 ENSG00000223774
GH01H201929 0.8 dbSUPER 30.7 +41.7 41662 2.3 HINFP ZNF493 TAL1 ZFP64 ZNF266 ZNF697 ZNF664 TCF12 CTBP1 EGR1 SHISA4 IPO9-AS1 HNRNPA1P59 ELF3-AS1 KDM5B IPO9 ENSG00000273478 RNPEP TIMM17A ENSG00000223774
GH01H201789 1.4 Ensembl ENCODE dbSUPER 8.9 -97.2 -97188 4.2 HDGF TBP RB1 ARNT ZNF2 RAD21 ZNF143 DEK ZNF654 REST ENSG00000235121 RNU6-501P NAV1 IPO9 IPO9-AS1 ENSG00000236390 CSRP1 ENSG00000224536 SHISA4 RNPEP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SHISA4 on UCSC Golden Path with GeneCards custom track

Promoters for SHISA4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000018202 231 601 SAP130 SIN3A YY1 HIC1 ZFHX2 GLIS2 MTA3 POLR2A EGR1 PRDM10

Genomic Locations for SHISA4 Gene

Genomic Locations for SHISA4 Gene
chr1:201,888,669-201,892,587
(GRCh38/hg38)
Size:
3,919 bases
Orientation:
Plus strand
chr1:201,857,797-201,861,715
(GRCh37/hg19)

Genomic View for SHISA4 Gene

Genes around SHISA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHISA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHISA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHISA4 Gene

Proteins for SHISA4 Gene

  • Protein details for SHISA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DD7-SHSA4_HUMAN
    Recommended name:
    Protein shisa-4
    Protein Accession:
    Q96DD7
    Secondary Accessions:
    • B4DFI0
    • B7ZAJ7
    • Q5VUU1
    • Q6P711
    • Q6UWY7

    Protein attributes for SHISA4 Gene

    Size:
    197 amino acids
    Molecular mass:
    21522 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH09558.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for SHISA4 Gene

Post-translational modifications for SHISA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SHISA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for SHISA4

No data available for DME Specific Peptides for SHISA4 Gene

Domains & Families for SHISA4 Gene

Gene Families for SHISA4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SHISA4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SHISA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96DD7

UniProtKB/Swiss-Prot:

SHSA4_HUMAN :
  • Belongs to the shisa family.
Family:
  • Belongs to the shisa family.
genes like me logo Genes that share domains with SHISA4: view

Function for SHISA4 Gene

Phenotypes From GWAS Catalog for SHISA4 Gene

genes like me logo Genes that share phenotypes with SHISA4: view

Animal Models for SHISA4 Gene

MGI Knock Outs for SHISA4:

Animal Model Products

CRISPR Products

miRNA for SHISA4 Gene

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SHISA4 Gene

Localization for SHISA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHISA4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SHISA4 gene
Compartment Confidence
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SHISA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SHISA4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SHISA4 Gene

Pathways & Interactions for SHISA4 Gene

SuperPathways for SHISA4 Gene

No Data Available

Interacting Proteins for SHISA4 Gene

Gene Ontology (GO) - Biological Process for SHISA4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SHISA4 Gene

Drugs & Compounds for SHISA4 Gene

No Compound Related Data Available

Transcripts for SHISA4 Gene

Unigene Clusters for SHISA4 Gene

Shisa homolog 4 (Xenopus laevis):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHISA4 Gene

No ASD Table

Relevant External Links for SHISA4 Gene

GeneLoc Exon Structure for
SHISA4
ECgene alternative splicing isoforms for
SHISA4

Expression for SHISA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SHISA4 Gene

mRNA differential expression in normal tissues according to GTEx for SHISA4 Gene

This gene is overexpressed in Muscle - Skeletal (x5.6).

Protein differential expression in normal tissues from HIPED for SHISA4 Gene

This gene is overexpressed in Frontal cortex (29.5), Fetal Brain (16.4), Retina (10.7), and Spinal cord (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SHISA4 Gene



Protein tissue co-expression partners for SHISA4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SHISA4 Gene:

SHISA4

SOURCE GeneReport for Unigene cluster for SHISA4 Gene:

Hs.632471

Evidence on tissue expression from TISSUES for SHISA4 Gene

  • Nervous system(4.8)
  • Muscle(4.6)
  • Kidney(4.2)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with SHISA4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SHISA4 Gene

Orthologs for SHISA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SHISA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SHISA4 33 34
  • 99.15 (n)
mouse
(Mus musculus)
Mammalia Shisa4 33 16 34
  • 90.74 (n)
cow
(Bos Taurus)
Mammalia SHISA4 33 34
  • 90.08 (n)
rat
(Rattus norvegicus)
Mammalia Shisa4 33
  • 89.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SHISA4 34
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SHISA4 34
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SHISA4 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia shisa4 33
  • 60.2 (n)
zebrafish
(Danio rerio)
Actinopterygii shisa4 33 34
  • 58.33 (n)
SHISA4 (3 of 3) 34
  • 24 (a)
OneToMany
SHISA4 (2 of 3) 34
  • 23 (a)
OneToMany
Species where no ortholog for SHISA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHISA4 Gene

ENSEMBL:
Gene Tree for SHISA4 (if available)
TreeFam:
Gene Tree for SHISA4 (if available)

Paralogs for SHISA4 Gene

No data available for Paralogs for SHISA4 Gene

Variants for SHISA4 Gene

Sequence variations from dbSNP and Humsavar for SHISA4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000199619 -- 201,889,121(+) AGGGG(A/G)GGGAC intron-variant
rs1000470261 -- 201,889,712(+) TTGTC(G/T)ACCTC intron-variant
rs1000980343 -- 201,895,950(+) TTTCC(A/G)AAGCT intron-variant
rs1001155578 -- 201,898,474(+) ACACA(A/C)AAGAC intron-variant
rs1001308692 -- 201,896,465(+) CTCTG(A/G)CTTTT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SHISA4 Gene

Variant ID Type Subtype PubMed ID
nsv521567 CNV loss 19592680

Variation tolerance for SHISA4 Gene

Residual Variation Intolerance Score: 72.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SHISA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SHISA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHISA4 Gene

Disorders for SHISA4 Gene

Relevant External Links for SHISA4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SHISA4

No disorders were found for SHISA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHISA4 Gene

Publications for SHISA4 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. (PMID: 17481602) Furushima K … Aizawa S (Developmental biology 2007) 3 60
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60

Products for SHISA4 Gene

Sources for SHISA4 Gene

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