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Aliases for SHISA4 Gene

Aliases for SHISA4 Gene

  • Shisa Family Member 4 2 3
  • Transmembrane Protein 58 2 3 4
  • C1orf40 3 4
  • TMEM58 3 4
  • Chromosome 1 Open Reading Frame 40 2
  • Shisa Homolog 4 (Xenopus Laevis) 2
  • Protein Shisa-4 3
  • Shisa Homolog 4 3

External Ids for SHISA4 Gene

Previous HGNC Symbols for SHISA4 Gene

  • C1orf40
  • TMEM58

Previous GeneCards Identifiers for SHISA4 Gene

  • GC01P200126
  • GC01P201857
  • GC01P173023

Summaries for SHISA4 Gene

GeneCards Summary for SHISA4 Gene

SHISA4 (Shisa Family Member 4) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHISA4 Gene

Genomics for SHISA4 Gene

Regulatory Elements for SHISA4 Gene

Genomic Location for SHISA4 Gene

201,888,669 bp from pter
201,892,587 bp from pter
3,919 bases
Plus strand

Genomic View for SHISA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SHISA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHISA4 Gene

Proteins for SHISA4 Gene

  • Protein details for SHISA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein shisa-4
    Protein Accession:
    Secondary Accessions:
    • B4DFI0
    • B7ZAJ7
    • Q5VUU1
    • Q6P711
    • Q6UWY7

    Protein attributes for SHISA4 Gene

    197 amino acids
    Molecular mass:
    21522 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH09558.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for SHISA4 Gene

Proteomics data for SHISA4 Gene at MOPED

Post-translational modifications for SHISA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SHISA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHISA4 Gene

Domains for SHISA4 Gene

Gene Families for SHISA4 Gene


Protein Domains for SHISA4 Gene


Suggested Antigen Peptide Sequences for SHISA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96DD7
  • Belongs to the shisa family.
genes like me logo Genes that share domains with SHISA4: view

Function for SHISA4 Gene

Phenotypes for SHISA4 Gene

MGI mutant phenotypes for SHISA4:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SHISA4: view

Animal Models for SHISA4 Gene

MGI Knock Outs for SHISA4:

Animal Model Products

miRNA for SHISA4 Gene

miRTarBase miRNAs that target SHISA4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SHISA4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targeting and HOMER Transcription for SHISA4 Gene

Localization for SHISA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHISA4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for SHISA4 Gene COMPARTMENTS Subcellular localization image for SHISA4 gene
Compartment Confidence
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SHISA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SHISA4: view

Pathways for SHISA4 Gene

SuperPathways for SHISA4 Gene

No Data Available

Interacting Proteins for SHISA4 Gene

Gene Ontology (GO) - Biological Process for SHISA4 Gene


No data available for Pathways by source for SHISA4 Gene

Transcripts for SHISA4 Gene

mRNA/cDNA for SHISA4 Gene

Unigene Clusters for SHISA4 Gene

Shisa homolog 4 (Xenopus laevis):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SHISA4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHISA4 Gene

No ASD Table

Relevant External Links for SHISA4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SHISA4 Gene

mRNA expression in normal human tissues for SHISA4 Gene

mRNA differential expression in normal tissues according to GTEx for SHISA4 Gene

This gene is overexpressed in Muscle - Skeletal (5.6).

Protein differential expression in normal tissues for SHISA4 Gene

This gene is overexpressed in Frontal cortex (29.5), Fetal Brain (16.4), Retina (10.7), and Spinal cord (9.8).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SHISA4 Gene

SOURCE GeneReport for Unigene cluster for SHISA4 Gene Hs.632471

genes like me logo Genes that share expressions with SHISA4: view

Expression partners for SHISA4 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SHISA4 Gene

Orthologs for SHISA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SHISA4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SHISA4 35
  • 90.08 (n)
  • 95.42 (a)
  • 95 (a)
(Mus musculus)
Mammalia Shisa4 35
  • 90.74 (n)
  • 91.11 (a)
Shisa4 16
Shisa4 36
  • 92 (a)
(Pan troglodytes)
Mammalia SHISA4 35
  • 99.15 (n)
  • 98.48 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Shisa4 35
  • 89.81 (n)
  • 90.56 (a)
(Monodelphis domestica)
Mammalia SHISA4 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia SHISA4 36
  • 84 (a)
(Anolis carolinensis)
Reptilia SHISA4 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia shisa4 35
  • 60.2 (n)
  • 55.76 (a)
(Danio rerio)
Actinopterygii shisa4 35
  • 58.33 (n)
  • 53.12 (a)
shisa4 36
  • 50 (a)
SHISA4 (2 of 3) 36
  • 23 (a)
SHISA4 (3 of 3) 36
  • 24 (a)
Species with no ortholog for SHISA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHISA4 Gene

Gene Tree for SHISA4 (if available)
Gene Tree for SHISA4 (if available)

Paralogs for SHISA4 Gene

No data available for Paralogs for SHISA4 Gene

Variants for SHISA4 Gene

Sequence variations from dbSNP and Humsavar for SHISA4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs937338 -- 201,888,306(+) CTGTC(C/G)ACTTG upstream-variant-2KB
rs2250377 - 201,891,498(+) TTCAT(A/G)TACCC reference, missense, nc-transcript-variant
rs2279681 -- 201,891,888(+) CCAAC(C/G)TTGGG utr-variant-3-prime, nc-transcript-variant
rs2279682 -- 201,891,893(+) CTTGG(C/G)AGATG utr-variant-3-prime, nc-transcript-variant
rs2644125 -- 201,892,778(+) aaggg(C/G/T)ggggg downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SHISA4 Gene

Variant ID Type Subtype PubMed ID
nsv521567 CNV Loss 19592680

Relevant External Links for SHISA4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHISA4 Gene

Disorders for SHISA4 Gene

No disorders were found for SHISA4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SHISA4 Gene

Publications for SHISA4 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. (PMID: 17481602) Furushima K. … Aizawa S. (Dev. Biol. 2007) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for SHISA4 Gene

Sources for SHISA4 Gene

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