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Aliases for SHISA4 Gene

Aliases for SHISA4 Gene

  • Shisa Family Member 4 2 3 5
  • Transmembrane Protein 58 2 3 4
  • C1orf40 3 4
  • TMEM58 3 4
  • Chromosome 1 Open Reading Frame 40 2
  • Shisa Homolog 4 (Xenopus Laevis) 2
  • Shisa Homolog 4 3

External Ids for SHISA4 Gene

Previous HGNC Symbols for SHISA4 Gene

  • C1orf40
  • TMEM58

Previous GeneCards Identifiers for SHISA4 Gene

  • GC01P200126
  • GC01P201857
  • GC01P173023

Summaries for SHISA4 Gene

GeneCards Summary for SHISA4 Gene

SHISA4 (Shisa Family Member 4) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHISA4 Gene

Genomics for SHISA4 Gene

Regulatory Elements for SHISA4 Gene

Promoters for SHISA4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SHISA4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SHISA4 Gene

Chromosome:
1
Start:
201,888,669 bp from pter
End:
201,892,587 bp from pter
Size:
3,919 bases
Orientation:
Plus strand

Genomic View for SHISA4 Gene

Genes around SHISA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHISA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHISA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHISA4 Gene

Proteins for SHISA4 Gene

  • Protein details for SHISA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DD7-SHSA4_HUMAN
    Recommended name:
    Protein shisa-4
    Protein Accession:
    Q96DD7
    Secondary Accessions:
    • B4DFI0
    • B7ZAJ7
    • Q5VUU1
    • Q6P711
    • Q6UWY7

    Protein attributes for SHISA4 Gene

    Size:
    197 amino acids
    Molecular mass:
    21522 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH09558.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for SHISA4 Gene

Proteomics data for SHISA4 Gene at MOPED

Post-translational modifications for SHISA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SHISA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for SHISA4
  • Santa Cruz Biotechnology (SCBT) Antibodies for SHISA4

No data available for DME Specific Peptides for SHISA4 Gene

Domains & Families for SHISA4 Gene

Gene Families for SHISA4 Gene

Protein Domains for SHISA4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SHISA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96DD7

UniProtKB/Swiss-Prot:

SHSA4_HUMAN :
  • Belongs to the shisa family.
Family:
  • Belongs to the shisa family.
genes like me logo Genes that share domains with SHISA4: view

Function for SHISA4 Gene

genes like me logo Genes that share phenotypes with SHISA4: view

Animal Models for SHISA4 Gene

MGI Knock Outs for SHISA4:

Animal Model Products

  • Taconic Biosciences Mouse Models for SHISA4

miRNA for SHISA4 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SHISA4 Gene

Localization for SHISA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHISA4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SHISA4 Gene COMPARTMENTS Subcellular localization image for SHISA4 gene
Compartment Confidence
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for SHISA4 Gene

Pathways & Interactions for SHISA4 Gene

SuperPathways for SHISA4 Gene

No Data Available

Interacting Proteins for SHISA4 Gene

Gene Ontology (GO) - Biological Process for SHISA4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SHISA4 Gene

Drugs & Compounds for SHISA4 Gene

No Compound Related Data Available

Transcripts for SHISA4 Gene

Unigene Clusters for SHISA4 Gene

Shisa homolog 4 (Xenopus laevis):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SHISA4 Gene

No ASD Table

Relevant External Links for SHISA4 Gene

GeneLoc Exon Structure for
SHISA4
ECgene alternative splicing isoforms for
SHISA4

Expression for SHISA4 Gene

mRNA expression in normal human tissues for SHISA4 Gene

mRNA differential expression in normal tissues according to GTEx for SHISA4 Gene

This gene is overexpressed in Muscle - Skeletal (x5.6).

Protein differential expression in normal tissues from HIPED for SHISA4 Gene

This gene is overexpressed in Frontal cortex (29.5), Fetal Brain (16.4), Retina (10.7), and Spinal cord (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SHISA4 Gene



SOURCE GeneReport for Unigene cluster for SHISA4 Gene Hs.632471

genes like me logo Genes that share expression patterns with SHISA4: view

Protein tissue co-expression partners for SHISA4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SHISA4 Gene

Orthologs for SHISA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SHISA4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SHISA4 35
  • 90.08 (n)
  • 95.42 (a)
SHISA4 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Shisa4 35
  • 90.74 (n)
  • 91.11 (a)
Shisa4 16
Shisa4 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SHISA4 35
  • 99.15 (n)
  • 98.48 (a)
SHISA4 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Shisa4 35
  • 89.81 (n)
  • 90.56 (a)
oppossum
(Monodelphis domestica)
Mammalia SHISA4 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SHISA4 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SHISA4 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia shisa4 35
  • 60.2 (n)
  • 55.76 (a)
zebrafish
(Danio rerio)
Actinopterygii shisa4 35
  • 58.33 (n)
  • 53.12 (a)
shisa4 36
  • 50 (a)
OneToMany
SHISA4 (2 of 3) 36
  • 23 (a)
OneToMany
SHISA4 (3 of 3) 36
  • 24 (a)
OneToMany
Species with no ortholog for SHISA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHISA4 Gene

ENSEMBL:
Gene Tree for SHISA4 (if available)
TreeFam:
Gene Tree for SHISA4 (if available)

Paralogs for SHISA4 Gene

No data available for Paralogs for SHISA4 Gene

Variants for SHISA4 Gene

Sequence variations from dbSNP and Humsavar for SHISA4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2250377 - 201,891,498(+) TTCAT(A/G)TACCC nc-transcript-variant, reference, missense
rs937338 -- 201,888,306(+) CTGTC(C/G)ACTTG upstream-variant-2KB
rs2279681 -- 201,891,888(+) CCAAC(A/C/G)TTGGG nc-transcript-variant, utr-variant-3-prime
rs2279682 -- 201,891,893(+) CTTGG(C/G)AGATG nc-transcript-variant, utr-variant-3-prime
rs2644125 -- 201,892,778(+) aaggg(C/G/T)ggggg downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SHISA4 Gene

Variant ID Type Subtype PubMed ID
nsv521567 CNV Loss 19592680

Variation tolerance for SHISA4 Gene

Residual Variation Intolerance Score: 72.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SHISA4 Gene

HapMap Linkage Disequilibrium report
SHISA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHISA4 Gene

Disorders for SHISA4 Gene

Relevant External Links for SHISA4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SHISA4

No disorders were found for SHISA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHISA4 Gene

Publications for SHISA4 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. (PMID: 17481602) Furushima K. … Aizawa S. (Dev. Biol. 2007) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for SHISA4 Gene

Sources for SHISA4 Gene

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