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Aliases for SHISA3 Gene

Aliases for SHISA3 Gene

  • Shisa Family Member 3 2 3 5
  • Shisa Homolog 3 (Xenopus Laevis) 2
  • Protein Shisa-3 Homolog 3
  • Shisa Homolog 3 3
  • HShisa3 3

External Ids for SHISA3 Gene

Previous GeneCards Identifiers for SHISA3 Gene

  • GC04P042095
  • GC04P041721

Summaries for SHISA3 Gene

Entrez Gene Summary for SHISA3 Gene

  • This gene encodes a single-transmembrane protein which is one of nine members of a family of transmembrane adaptors that modulate both WNT and FGF signaling by blocking the maturation and transport of their receptors to the cell surface. Members of this family contain an N-terminal cysteine-rich domain with a distinct cysteine pattern, a single transmembrane domain, and a C-terminal proline-rich, low complexity region. The encoded protein acts as a tumor suppressor by accelerating beta-catenin degradation. [provided by RefSeq, Jul 2017]

GeneCards Summary for SHISA3 Gene

SHISA3 (Shisa Family Member 3) is a Protein Coding gene. An important paralog of this gene is SHISA2.

UniProtKB/Swiss-Prot for SHISA3 Gene

  • Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.

Additional gene information for SHISA3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHISA3 Gene

Genomics for SHISA3 Gene

Regulatory Elements for SHISA3 Gene

Enhancers for SHISA3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H042425 1.4 ENCODE 12.1 +27.7 27736 0 POU5F1 SHISA3 LOC105374428 ATP8A1 RPS7P7
GH04H042638 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4.6 +244.0 243958 5 HDGF PKNOX1 TBL1XR1 SIN3A BMI1 BATF RFX5 ATF7 ETV6 RUNX3 ATP8A1 SHISA3 GRXCR1 GC04P042610
GH04H042607 0.5 dbSUPER 4.7 +210.2 210197 1 MAFF ZNF316 EMSY WT1 MAFK ATP8A1 SHISA3 GC04P042610 GC04P042579
GH04H041419 0.4 dbSUPER 4.5 -977.5 -977476 2 ZNF366 LIMCH1 SHISA3 DCAF4L1 GC04P041427 GC04P041402
GH04H042397 0.6 ENCODE 0.7 -0.4 -421 0 GLIS2 POLR2A CTBP2 PRDM10 ZBTB26 EZH2 SHISA3 LOC105374428
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SHISA3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SHISA3 Gene

Chromosome:
4
Start:
42,397,839 bp from pter
End:
42,402,487 bp from pter
Size:
4,649 bases
Orientation:
Plus strand

Genomic View for SHISA3 Gene

Genes around SHISA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHISA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHISA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHISA3 Gene

Proteins for SHISA3 Gene

  • Protein details for SHISA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0PJX4-SHSA3_HUMAN
    Recommended name:
    Protein shisa-3 homolog
    Protein Accession:
    A0PJX4
    Secondary Accessions:
    • A0PJX3
    • Q96EQ5

    Protein attributes for SHISA3 Gene

    Size:
    238 amino acids
    Molecular mass:
    25832 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SHISA3 Gene

Post-translational modifications for SHISA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SHISA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHISA3 Gene

Domains & Families for SHISA3 Gene

Gene Families for SHISA3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SHISA3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SHISA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A0PJX4

UniProtKB/Swiss-Prot:

SHSA3_HUMAN :
  • Belongs to the shisa family.
Family:
  • Belongs to the shisa family.
genes like me logo Genes that share domains with SHISA3: view

Function for SHISA3 Gene

Molecular function for SHISA3 Gene

UniProtKB/Swiss-Prot Function:
Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.

Gene Ontology (GO) - Molecular Function for SHISA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SHISA3: view

Phenotypes for SHISA3 Gene

MGI mutant phenotypes for SHISA3:
inferred from 1 alleles
GenomeRNAi human phenotypes for SHISA3:
genes like me logo Genes that share phenotypes with SHISA3: view

Animal Models for SHISA3 Gene

MGI Knock Outs for SHISA3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SHISA3

CRISPR Products

miRNA for SHISA3 Gene

miRTarBase miRNAs that target SHISA3

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SHISA3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SHISA3 Gene

Localization for SHISA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHISA3 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SHISA3 gene
Compartment Confidence
plasma membrane 3
extracellular 3
endoplasmic reticulum 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Lipid droplets (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SHISA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SHISA3: view

Pathways & Interactions for SHISA3 Gene

SuperPathways for SHISA3 Gene

No Data Available

Interacting Proteins for SHISA3 Gene

Selected Interacting proteins: A0PJX4-SHSA3_HUMAN for SHISA3 Gene via UniProtKB IID

Symbol External ID(s) Details
PNMA1

Gene Ontology (GO) - Biological Process for SHISA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with SHISA3: view

No data available for Pathways by source and SIGNOR curated interactions for SHISA3 Gene

Drugs & Compounds for SHISA3 Gene

No Compound Related Data Available

Transcripts for SHISA3 Gene

mRNA/cDNA for SHISA3 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(30) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SHISA3 Gene

Shisa homolog 3 (Xenopus laevis):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SHISA3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SHISA3 Gene

No ASD Table

Relevant External Links for SHISA3 Gene

GeneLoc Exon Structure for
SHISA3
ECgene alternative splicing isoforms for
SHISA3

Expression for SHISA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SHISA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SHISA3 Gene

This gene is overexpressed in Kidney - Cortex (x5.5), Nerve - Tibial (x4.9), and Heart - Atrial Appendage (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of SHISA3 Gene:

SHISA3

SOURCE GeneReport for Unigene cluster for SHISA3 Gene:

Hs.370904
genes like me logo Genes that share expression patterns with SHISA3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SHISA3 Gene

Orthologs for SHISA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SHISA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SHISA3 33 34
  • 99.58 (n)
cow
(Bos Taurus)
Mammalia SHISA3 33 34
  • 91.22 (n)
oppossum
(Monodelphis domestica)
Mammalia SHISA3 34
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Shisa3 33 16 34
  • 87.8 (n)
rat
(Rattus norvegicus)
Mammalia Shisa3 33
  • 87.05 (n)
dog
(Canis familiaris)
Mammalia SHISA3 33 34
  • 79.77 (n)
chicken
(Gallus gallus)
Aves SHISA3 33 34
  • 73.73 (n)
lizard
(Anolis carolinensis)
Reptilia SHISA3 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia shisa3 33
  • 71.39 (n)
zebrafish
(Danio rerio)
Actinopterygii shisa3 33 34
  • 64.71 (n)
Species where no ortholog for SHISA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHISA3 Gene

ENSEMBL:
Gene Tree for SHISA3 (if available)
TreeFam:
Gene Tree for SHISA3 (if available)

Paralogs for SHISA3 Gene

Paralogs for SHISA3 Gene

(1) SIMAP similar genes for SHISA3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SHISA3 Gene

genes like me logo Genes that share paralogs with SHISA3: view

Variants for SHISA3 Gene

Sequence variations from dbSNP and Humsavar for SHISA3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000204885 -- 42,399,222(+) CAGAG(A/G)GCCGA intron-variant
rs1001160939 -- 42,396,745(+) TTTCC(C/T)TGAAC upstream-variant-2KB
rs1001445144 -- 42,396,961(+) ACGTA(C/G)GTGGA upstream-variant-2KB
rs1001827016 -- 42,398,683(+) TAGAC(A/G/T)TGGGT intron-variant
rs1003237587 -- 42,397,679(+) GGCAG(A/C)CCCGG upstream-variant-2KB

Variation tolerance for SHISA3 Gene

Residual Variation Intolerance Score: 41.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.36; 81.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SHISA3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SHISA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SHISA3 Gene

Disorders for SHISA3 Gene

Relevant External Links for SHISA3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SHISA3

No disorders were found for SHISA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHISA3 Gene

Publications for SHISA3 Gene

  1. Increased SHISA3 expression characterizes chronic lymphocytic leukemia patients sensitive to lenalidomide. (PMID: 28639485) Maffei R … Marasca R (Leukemia & lymphoma 2017) 3 60
  2. SHISA3 (PMID: 28299336) Shen Z … Zhang Y (BioMed research international 2017) 3 60
  3. DNA Hypermethylation of SHISA3 in Colorectal Cancer: An Independent Predictor of Poor Prognosis. (PMID: 25968618) Tsai MH … Yang YC (Annals of surgical oncology 2015) 3 60
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  5. Shisa3 is associated with prolonged survival through promoting β-catenin degradation in lung cancer. (PMID: 25036006) Chen CC … Yu SL (American journal of respiratory and critical care medicine 2014) 3 60

Products for SHISA3 Gene

Sources for SHISA3 Gene

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