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Aliases for SHISA3 Gene

Aliases for SHISA3 Gene

  • Shisa Family Member 3 2 3
  • Shisa Homolog 3 (Xenopus Laevis) 2
  • Protein Shisa-3 Homolog 3
  • Shisa Homolog 3 3
  • HShisa3 3

External Ids for SHISA3 Gene

Previous GeneCards Identifiers for SHISA3 Gene

  • GC04P042095
  • GC04P041721

Summaries for SHISA3 Gene

GeneCards Summary for SHISA3 Gene

SHISA3 (Shisa Family Member 3) is a Protein Coding gene. Among its related pathways are Non-Canonical Wnt Pathway and Non-Canonical Wnt Pathway. An important paralog of this gene is SHISA2.

UniProtKB/Swiss-Prot for SHISA3 Gene

  • Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHISA3 Gene

Genomics for SHISA3 Gene

Regulatory Elements for SHISA3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SHISA3 Gene

42,397,839 bp from pter
42,402,487 bp from pter
4,649 bases
Plus strand

Genomic View for SHISA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SHISA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHISA3 Gene

Proteins for SHISA3 Gene

  • Protein details for SHISA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein shisa-3 homolog
    Protein Accession:
    Secondary Accessions:
    • A0PJX3
    • Q96EQ5

    Protein attributes for SHISA3 Gene

    238 amino acids
    Molecular mass:
    25832 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SHISA3 Gene

Proteomics data for SHISA3 Gene at MOPED

Post-translational modifications for SHISA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SHISA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHISA3 Gene

Domains for SHISA3 Gene

Gene Families for SHISA3 Gene


Protein Domains for SHISA3 Gene


Suggested Antigen Peptide Sequences for SHISA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • A0PJX4
  • Belongs to the shisa family.
genes like me logo Genes that share domains with SHISA3: view

Function for SHISA3 Gene

Molecular function for SHISA3 Gene

UniProtKB/Swiss-Prot Function: Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.

Gene Ontology (GO) - Molecular Function for SHISA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SHISA3: view

Phenotypes for SHISA3 Gene

MGI mutant phenotypes for SHISA3:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SHISA3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SHISA3 Gene

Localization for SHISA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHISA3 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for SHISA3 Gene COMPARTMENTS Subcellular localization image for SHISA3 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SHISA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SHISA3: view

Pathways for SHISA3 Gene

SuperPathways for SHISA3 Gene

genes like me logo Genes that share pathways with SHISA3: view

Pathways by source for SHISA3 Gene

2 Sino Biological pathways for SHISA3 Gene

Interacting Proteins for SHISA3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000326445 A0PJX4-SHSA3_HUMAN for SHISA3 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for SHISA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
genes like me logo Genes that share ontologies with SHISA3: view

Transcripts for SHISA3 Gene

mRNA/cDNA for SHISA3 Gene

(30) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SHISA3 Gene

Shisa homolog 3 (Xenopus laevis):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SHISA3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SHISA3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHISA3 Gene

No ASD Table

Relevant External Links for SHISA3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SHISA3 Gene

mRNA expression in normal human tissues for SHISA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SHISA3 Gene

This gene is overexpressed in Kidney - Cortex (5.5), Nerve - Tibial (4.9), and Heart - Atrial Appendage (4.3).

SOURCE GeneReport for Unigene cluster for SHISA3 Gene Hs.370904

genes like me logo Genes that share expressions with SHISA3: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for SHISA3 Gene

Orthologs for SHISA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SHISA3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SHISA3 35
  • 99.58 (n)
  • 99.16 (a)
  • 99 (a)
(Bos Taurus)
Mammalia SHISA3 35
  • 91.22 (n)
  • 95.98 (a)
  • 96 (a)
(Canis familiaris)
Mammalia SHISA3 35
  • 79.77 (n)
  • 82.08 (a)
  • 91 (a)
(Mus musculus)
Mammalia Shisa3 35
  • 87.8 (n)
  • 94.2 (a)
Shisa3 16
Shisa3 36
  • 93 (a)
(Monodelphis domestica)
Mammalia SHISA3 36
  • 91 (a)
(Rattus norvegicus)
Mammalia Shisa3 35
  • 87.05 (n)
  • 93.75 (a)
(Gallus gallus)
Aves SHISA3 35
  • 73.73 (n)
  • 74.19 (a)
  • 68 (a)
(Anolis carolinensis)
Reptilia SHISA3 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia shisa3 35
  • 71.39 (n)
  • 76.61 (a)
(Danio rerio)
Actinopterygii shisa3 35
  • 64.71 (n)
  • 65.61 (a)
shisa3 36
  • 52 (a)
Species with no ortholog for SHISA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHISA3 Gene

Gene Tree for SHISA3 (if available)
Gene Tree for SHISA3 (if available)

Paralogs for SHISA3 Gene

Paralogs for SHISA3 Gene

Selected SIMAP similar genes for SHISA3 Gene using alignment to 1 proteins: Pseudogenes for SHISA3 Gene

genes like me logo Genes that share paralogs with SHISA3: view

Variants for SHISA3 Gene

Sequence variations from dbSNP and Humsavar for SHISA3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs2046633 -- 42,397,000(+) AAACC(A/G)TGTTC upstream-variant-2KB
rs2242335 -- 42,396,886(+) AGCCG(A/G)CGGAA upstream-variant-2KB
rs2242336 -- 42,397,055(+) GTCTG(C/T)GCAAC upstream-variant-2KB
rs2632704 -- 42,396,697(+) CCCTG(A/G)AAATA upstream-variant-2KB
rs3103219 -- 42,397,318(+) CGGGG(A/G)GAGGC upstream-variant-2KB

Relevant External Links for SHISA3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SHISA3 Gene

Disorders for SHISA3 Gene

No disorders were found for SHISA3 Gene.

No data available for UniProtKB/Swiss-Prot for SHISA3 Gene

Publications for SHISA3 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. (PMID: 17481602) Furushima K. … Aizawa S. (Dev. Biol. 2007) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for SHISA3 Gene

Sources for SHISA3 Gene

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