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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SHISA3 Gene

protein-coding   GIFtS: 38
GCID: GC04P042399

shisa homolog 3 (Xenopus laevis)
  Search for SHISA3
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SHISA3    

Aliases
for SHISA3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Shisa Homolog 3 (Xenopus Laevis)1 2
HShisa31
Protein Shisa-3 Homolog2

External Ids:    HGNC: 251591   Entrez Gene: 1525732   Ensembl: ENSG000001783437   UniProtKB: A0PJX43   

Export aliases for SHISA3 gene to outside databases

Previous GC identifers: GC04P042095 GC04P041721


Summaries
for SHISA3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SHSA3_HUMAN, A0PJX4
Function: Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF
and WNT signaling (By similarity)




Genomic Views
for SHISA3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006238.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SHISA3 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   S8   SRY   E2F-1   E2F   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SHISA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHISA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p13   Ensembl cytogenetic band:  4p13   HGNC cytogenetic band: 4p13

SHISA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHISA3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P042399:  view genomic region     (about GC identifiers)

Start:
 42,399,856 bp from pter      End:
 42,404,504 bp from pter
Size:
 4,649 bases      Orientation:
 plus strand

Proteins
for SHISA3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SHSA3_HUMAN, A0PJX4 (See protein sequence)
Recommended Name: Protein shisa-3 homolog precursor  
Size: 238 amino acids; 25832 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity)
Secondary accessions: A0PJX3 Q96EQ5

Explore the universe of human proteins at neXtProt for SHISA3: NX_A0PJX4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_A0PJX4

    • SHISA3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001073974.1  
    ENSEMBL proteins: 
     ENSP00000326445  

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    Uscn Proteins for SHISA3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--


    SHISA3 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SHISA3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SHISA3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026910 Shisa

    Graphical View of Domain Structure for InterPro Entry A0PJX4

    ProtoNet protein and cluster: A0PJX4

    UniProtKB/Swiss-Prot: SHSA3_HUMAN, A0PJX4
    Similarity: Belongs to the shisa family


    Function
    for SHISA3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SHSA3_HUMAN, A0PJX4
    Function: Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF
    and WNT signaling (By similarity)

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    In Situ Assay
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    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Shisa3):
     normal 

    SHISA3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SHISA3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SHISA3

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--


    SHISA3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SHISA3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SHISA3
    Search CenterWatch for drugs/clinical trials and news about SHISA3 / SHSA3 

    Transcripts
    for SHISA3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SHISA3 gene: 
    NM_001080505.1  

    Unigene Cluster for SHISA3:

    Shisa homolog 3 (Xenopus laevis)
    Hs.370904  [show with all ESTs]
    Unigene Representative Sequence: NM_001080505
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000319234(uc003gwp.3)

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    hsa-miR-323-3p hsa-miR-4307 hsa-miR-520d-5p hsa-miR-4282 hsa-miR-33a* hsa-miR-129-3p hsa-miR-524-5p hsa-miR-32*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SHISA3 (see all 4)
    OriGene shRNA RFP: SHISA3
    OriGene siRNA: SHISA3
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    Clone
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    Primer
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    Additional cDNA sequence: 

    BC012029.1 BC127690.1 BC127691.1 

    2 DOTS entries:

    DT.207977  DT.99943302 

    24/30 AceView cDNA sequences (see all 30):

    AW241377 BE350501 AA573206 BU682769 CB410420 CR624275 BC012029 BE326906 
    BG179496 BX328985 BX354731 BG284787 BG779845 AI735586 AI540415 AI376670 
    AI522318 BI759667 BX354732 BU858908 BG254440 AA131359 BX328986 BF668303 

    GeneLoc Exon Structure


    Expression
    for SHISA3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SHISA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACTCTAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SHISA3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyMetanephrosKidney
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    Sclerotome cells (Primary Cell)Bone, Cartilage, Somite
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    ES04(HES-4) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Definitive endoderm-like cells (A scalable, suspensi...)
    Mesoderm-like cells (Derivation of cardio...)

    See SHISA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SHISA3

    SOURCE GeneReport for Unigene cluster: Hs.370904
        SABiosciences Custom PCR Arrays for SHISA3
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHISA3

    Orthologs
    for SHISA3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SHISA3 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Shisa31 , 5 shisa homolog 3 (Xenopus laevis)1, 5 87.11(n)1
    92.86(a)1    		   5 (36.15 cM)5
    3300961  NM_001033415.31  NP_001028587.11 
     676078835 
    chicken
    (Gallus gallus)    		 Aves LOC1008573191 protein shisa-3 homolog 69.74(n)
    71.05(a)    		   100857319  XM_003641241.1  XP_003641289.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SHISA36
    		 --
    		 62(a)
    		 1 ↔ 1
    		 5(101291548-101296093)
    zebrafish
    (Danio rerio)    		 Actinopterygii shisa36
    		 shisa homolog 3 (Xenopus laevis)
    		 54(a)
    		 1 ↔ 1
    		 14(48138708-48144926)


    ENSEMBL Gene Tree for SHISA3 (if available)
    TreeFam Gene Tree for SHISA3 (if available) 

    Paralogs
    for SHISA3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SHISA3 gene
    SHISA22  
    1 SIMAP similar gene for SHISA3 using alignment to 1 protein entry:     SHSA3_HUMAN:
    SHISA2

    SHISA3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SHISA3
    PGOHUM00000241812


    Genomic Variants
    for SHISA3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SHISA3
    DNA2.0 Custom Variant and Variant Library Synthesis for SHISA3

    Disorders / Diseases
    for SHISA3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for SHISA3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SHISA3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SHISA3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. (PubMed id 17481602)1 Furushima K....Aizawa S. (2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    4. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    External Searches for SHISA3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SHISA3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 152573 HGNC: 25159 AceView: LOC152573 Ensembl:ENSG00000178343 euGenes: HUgn152573
    ECgene: SHISA3 H-InvDB: SHISA3

    Other Databases showing SHISA3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SHISA3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SHISA3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SHISA3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SHISA3 gene:
    Search GeneIP for patents involving SHISA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    von Willebrand factor
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