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Aliases for SHISA2 Gene

Aliases for SHISA2 Gene

  • Shisa Family Member 2 2 3 5
  • Transmembrane Protein 46 2 3 4
  • C13orf13 3 4
  • TMEM46 3 4
  • Chromosome 13 Open Reading Frame 13 2
  • Shisa Homolog 2 (Xenopus Laevis) 2
  • Protein Shisa-2 Homolog 3
  • Shisa Homolog 2 3
  • BA398O19.2 3
  • PRO28631 3
  • WGAR9166 3
  • HShisa 3

External Ids for SHISA2 Gene

Previous HGNC Symbols for SHISA2 Gene

  • C13orf13
  • TMEM46

Previous GeneCards Identifiers for SHISA2 Gene

  • GC13M025516
  • GC13M026618
  • GC13M007436

Summaries for SHISA2 Gene

GeneCards Summary for SHISA2 Gene

SHISA2 (Shisa Family Member 2) is a Protein Coding gene. An important paralog of this gene is SHISA3.

UniProtKB/Swiss-Prot for SHISA2 Gene

  • Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.

Additional gene information for SHISA2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHISA2 Gene

Genomics for SHISA2 Gene

GeneHancer (GH) Regulatory Elements for SHISA2 Gene

Promoters and enhancers for SHISA2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I026048 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 561.6 +8.6 8621 4.3 ZSCAN4 SIN3A FEZF1 ZNF335 GLIS2 SCRT2 ZNF143 REST ZFP69B GLIS1 SHISA2 PABPC3 LINC00415 PIR56473
GH13I025881 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 10.5 +177.6 177590 1.8 BACH1 ZNF335 SP1 GATA3 CREB1 FOXP2 PRDM10 RCOR1 ZXDB CHD2 SHISA2 LINC00415 CDK8 PIR50437 GC13P025866 RN7SL741P ATP8A2
GH13I026061 Enhancer 0.6 ENCODE 13.5 -2.6 -2639 1.4 CTCF PKNOX1 ZNF654 FEZF1 ZNF843 RAD21 SMC3 ZNF143 FOS SHISA2 PRUNEP1
GH13I026074 Enhancer 0.4 Ensembl 17.1 -15.3 -15275 0.6 CTCF TEAD3 SHISA2 LINC00415 PRUNEP1
GH13I025574 Enhancer 0.6 ENCODE 11.3 +484.9 484949 0.2 SCRT1 CTCF ZNF654 BHLHE40 TRIM22 REST RAD21 GATA3 ZNF366 SCRT2 LINC00415 SHISA2 PIR39066 RNU6-78P ATP8A2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SHISA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SHISA2 gene promoter:

Genomic Locations for SHISA2 Gene

Genomic Locations for SHISA2 Gene
14,991 bases
Minus strand

Genomic View for SHISA2 Gene

Genes around SHISA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHISA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHISA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHISA2 Gene

Proteins for SHISA2 Gene

  • Protein details for SHISA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein shisa-2 homolog
    Protein Accession:
    Secondary Accessions:
    • B9EH70
    • Q5W0G8

    Protein attributes for SHISA2 Gene

    295 amino acids
    Molecular mass:
    31375 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SHISA2 Gene

Post-translational modifications for SHISA2 Gene

No Post-translational modifications

Other Protein References for SHISA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHISA2 Gene

Domains & Families for SHISA2 Gene

Gene Families for SHISA2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SHISA2 Gene


Suggested Antigen Peptide Sequences for SHISA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the shisa family.
  • Belongs to the shisa family.
genes like me logo Genes that share domains with SHISA2: view

Function for SHISA2 Gene

Molecular function for SHISA2 Gene

UniProtKB/Swiss-Prot Function:
Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.
genes like me logo Genes that share phenotypes with SHISA2: view

Animal Models for SHISA2 Gene

MGI Knock Outs for SHISA2:

miRNA for SHISA2 Gene

miRTarBase miRNAs that target SHISA2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SHISA2 Gene

Localization for SHISA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHISA2 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SHISA2 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 3
nucleus 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SHISA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SHISA2: view

Pathways & Interactions for SHISA2 Gene

SuperPathways for SHISA2 Gene

No Data Available

Interacting Proteins for SHISA2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000313079 Q6UWI4-SHSA2_HUMAN for SHISA2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SHISA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0030178 negative regulation of Wnt signaling pathway IEA --
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with SHISA2: view

No data available for Pathways by source and SIGNOR curated interactions for SHISA2 Gene

Drugs & Compounds for SHISA2 Gene

No Compound Related Data Available

Transcripts for SHISA2 Gene

mRNA/cDNA for SHISA2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SHISA2 Gene

Shisa homolog 2 (Xenopus laevis):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHISA2 Gene

No ASD Table

Relevant External Links for SHISA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SHISA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SHISA2 Gene

mRNA differential expression in normal tissues according to GTEx for SHISA2 Gene

This gene is overexpressed in Thyroid (x10.5) and Muscle - Skeletal (x4.7).

Protein differential expression in normal tissues from HIPED for SHISA2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SHISA2 Gene

Protein tissue co-expression partners for SHISA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SHISA2 Gene:


SOURCE GeneReport for Unigene cluster for SHISA2 Gene:


Evidence on tissue expression from TISSUES for SHISA2 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with SHISA2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SHISA2 Gene

Orthologs for SHISA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SHISA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SHISA2 33 34
  • 99.21 (n)
(Ornithorhynchus anatinus)
Mammalia SHISA2 34
  • 95 (a)
(Canis familiaris)
Mammalia SHISA2 33 34
  • 91.32 (n)
(Monodelphis domestica)
Mammalia SHISA2 34
  • 91 (a)
(Bos Taurus)
Mammalia SHISA2 33 34
  • 88.72 (n)
(Rattus norvegicus)
Mammalia Shisa2 33
  • 87.01 (n)
(Mus musculus)
Mammalia Shisa2 33 16 34
  • 86.89 (n)
(Gallus gallus)
Aves SHISA2 33 34
  • 82.38 (n)
(Anolis carolinensis)
Reptilia SHISA2 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia shisa2 33
  • 75.8 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68837 33
(Danio rerio)
Actinopterygii LOC100537021 33
  • 66.25 (n)
  • 56 (a)
Species where no ortholog for SHISA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHISA2 Gene

Gene Tree for SHISA2 (if available)
Gene Tree for SHISA2 (if available)

Paralogs for SHISA2 Gene

Paralogs for SHISA2 Gene

(1) SIMAP similar genes for SHISA2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SHISA2: view

Variants for SHISA2 Gene

Sequence variations from dbSNP and Humsavar for SHISA2 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000058430 -- 26,049,530(-) G/A intron_variant
rs1000211055 -- 26,046,285(-) CACA/CA 3_prime_UTR_variant
rs1000333273 -- 26,051,143(-) A/G upstream_transcript_variant
rs1000450572 -- 26,045,791(-) A/C 3_prime_UTR_variant
rs1000818328 -- 26,052,470(-) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SHISA2 Gene

Variant ID Type Subtype PubMed ID
esv2747161 CNV deletion 23290073
nsv435952 OTHER inversion 17901297
nsv832569 CNV loss 17160897
nsv952529 CNV deletion 24416366

Variation tolerance for SHISA2 Gene

Residual Variation Intolerance Score: 84.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.54; 77.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SHISA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHISA2 Gene

Disorders for SHISA2 Gene

Additional Disease Information for SHISA2

No disorders were found for SHISA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHISA2 Gene

Publications for SHISA2 Gene

  1. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 58

Products for SHISA2 Gene

Sources for SHISA2 Gene

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