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Aliases for SHISA2 Gene

Aliases for SHISA2 Gene

  • Shisa Family Member 2 2 3 5
  • Transmembrane Protein 46 2 3 4
  • C13orf13 3 4
  • TMEM46 3 4
  • Chromosome 13 Open Reading Frame 13 2
  • Shisa Homolog 2 (Xenopus Laevis) 2
  • Protein Shisa-2 Homolog 3
  • Shisa Homolog 2 3
  • BA398O19.2 3
  • PRO28631 3
  • WGAR9166 3
  • HShisa 3

External Ids for SHISA2 Gene

Previous HGNC Symbols for SHISA2 Gene

  • C13orf13
  • TMEM46

Previous GeneCards Identifiers for SHISA2 Gene

  • GC13M025516
  • GC13M026618
  • GC13M007436

Summaries for SHISA2 Gene

GeneCards Summary for SHISA2 Gene

SHISA2 (Shisa Family Member 2) is a Protein Coding gene. An important paralog of this gene is SHISA3.

UniProtKB/Swiss-Prot for SHISA2 Gene

  • Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHISA2 Gene

Genomics for SHISA2 Gene

Regulatory Elements for SHISA2 Gene

Enhancers for SHISA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F026074 0.4 Ensembl 17.1 -15.3 -15299 0.6 CTCF TEAD3 SHISA2 LINC00415 PRUNEP1
GH13F026061 0.6 ENCODE 13.4 -2.6 -2639 1.4 SOX13 CTCF PKNOX1 ZNF654 FEZF1 CEBPG ZNF843 RAD21 FOXK2 ETV4 SHISA2 PRUNEP1
GH13F026048 0.4 ENCODE 11.5 +8.6 8618 4.3 CBX3 ZNF133 SIN3A FEZF1 GLIS2 SCRT2 REST ZFP69B SMARCA4 GLIS1 SHISA2 PABPC3 LINC00415 PIR56473
GH13F026030 0.2 ENCODE 11.4 +29.1 29090 0.2 NR2F2 LINC00415 SHISA2 PIR56473
GH13F025574 0.8 ENCODE 11.3 +485.0 484950 0.2 SCRT1 CTCF ZNF654 BHLHE40 HLF REST RAD21 NFIL3 SMARCA4 ZNF366 LINC00415 SHISA2 PIR39066 RNU6-78P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SHISA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SHISA2 Gene

26,044,597 bp from pter
26,059,587 bp from pter
14,991 bases
Minus strand

Genomic View for SHISA2 Gene

Genes around SHISA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHISA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHISA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHISA2 Gene

Proteins for SHISA2 Gene

  • Protein details for SHISA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein shisa-2 homolog
    Protein Accession:
    Secondary Accessions:
    • B9EH70
    • Q5W0G8

    Protein attributes for SHISA2 Gene

    295 amino acids
    Molecular mass:
    31375 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SHISA2 Gene

Post-translational modifications for SHISA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SHISA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHISA2 Gene

Domains & Families for SHISA2 Gene

Gene Families for SHISA2 Gene

Protein Domains for SHISA2 Gene


Suggested Antigen Peptide Sequences for SHISA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the shisa family.
  • Belongs to the shisa family.
genes like me logo Genes that share domains with SHISA2: view

Function for SHISA2 Gene

Molecular function for SHISA2 Gene

UniProtKB/Swiss-Prot Function:
Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.
genes like me logo Genes that share phenotypes with SHISA2: view

Animal Models for SHISA2 Gene

MGI Knock Outs for SHISA2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SHISA2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SHISA2 Gene

Localization for SHISA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHISA2 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for SHISA2 Gene COMPARTMENTS Subcellular localization image for SHISA2 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 3
nucleus 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SHISA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SHISA2: view

Pathways & Interactions for SHISA2 Gene

SuperPathways for SHISA2 Gene

No Data Available

Interacting Proteins for SHISA2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000313079 Q6UWI4-SHSA2_HUMAN for SHISA2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SHISA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0030178 negative regulation of Wnt signaling pathway IEA --
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with SHISA2: view

No data available for Pathways by source and SIGNOR curated interactions for SHISA2 Gene

Transcripts for SHISA2 Gene

mRNA/cDNA for SHISA2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SHISA2 Gene

Shisa homolog 2 (Xenopus laevis):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHISA2 Gene

No ASD Table

Relevant External Links for SHISA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SHISA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SHISA2 Gene

mRNA differential expression in normal tissues according to GTEx for SHISA2 Gene

This gene is overexpressed in Thyroid (x10.5) and Muscle - Skeletal (x4.7).

Protein differential expression in normal tissues from HIPED for SHISA2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SHISA2 Gene

Protein tissue co-expression partners for SHISA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SHISA2 Gene:


SOURCE GeneReport for Unigene cluster for SHISA2 Gene:

genes like me logo Genes that share expression patterns with SHISA2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SHISA2 Gene

Orthologs for SHISA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SHISA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SHISA2 34 35
  • 99.21 (n)
(Ornithorhynchus anatinus)
Mammalia SHISA2 35
  • 95 (a)
(Canis familiaris)
Mammalia SHISA2 34 35
  • 91.32 (n)
(Monodelphis domestica)
Mammalia SHISA2 35
  • 91 (a)
(Bos Taurus)
Mammalia SHISA2 34 35
  • 88.72 (n)
(Rattus norvegicus)
Mammalia Shisa2 34
  • 87.01 (n)
(Mus musculus)
Mammalia Shisa2 34 16 35
  • 86.89 (n)
(Gallus gallus)
Aves SHISA2 34 35
  • 82.38 (n)
(Anolis carolinensis)
Reptilia SHISA2 35
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia shisa2 34
  • 75.8 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68837 34
(Danio rerio)
Actinopterygii LOC100537021 34
  • 66.25 (n)
  • 56 (a)
Species where no ortholog for SHISA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHISA2 Gene

Gene Tree for SHISA2 (if available)
Gene Tree for SHISA2 (if available)

Paralogs for SHISA2 Gene

Paralogs for SHISA2 Gene

(1) SIMAP similar genes for SHISA2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SHISA2: view

Variants for SHISA2 Gene

Sequence variations from dbSNP and Humsavar for SHISA2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1055252 -- 26,044,784(-) CAAAT(C/T)GCTGT utr-variant-3-prime
rs111354107 -- 26,050,020(+) AAAAA(-/A)TCAAA intron-variant
rs111385170 -- 26,052,118(+) CGCCC(A/G)CGGGC downstream-variant-500B, upstream-variant-2KB
rs111516934 -- 26,050,797(+) CGCCG(C/T)CGTCG reference, missense
rs111705560 -- 26,047,390(+) GACAG(C/T)TATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SHISA2 Gene

Variant ID Type Subtype PubMed ID
esv2747161 CNV deletion 23290073
nsv435952 OTHER inversion 17901297
nsv832569 CNV loss 17160897
nsv952529 CNV deletion 24416366

Variation tolerance for SHISA2 Gene

Residual Variation Intolerance Score: 84.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.54; 77.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SHISA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHISA2 Gene

Disorders for SHISA2 Gene

Relevant External Links for SHISA2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SHISA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHISA2 Gene

Publications for SHISA2 Gene

  1. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
  5. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PMID: 22889411) Guo Z. … Gao Y. (J. Proteome Res. 2012) 3 64

Products for SHISA2 Gene

Sources for SHISA2 Gene

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