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Aliases for SHISA2 Gene

Aliases for SHISA2 Gene

  • Shisa Family Member 2 2 3
  • Transmembrane Protein 46 2 3 4
  • C13orf13 3 4
  • TMEM46 3 4
  • Chromosome 13 Open Reading Frame 13 2
  • Shisa Homolog 2 (Xenopus Laevis) 2
  • Protein Shisa-2 Homolog 3
  • Shisa Homolog 2 3
  • BA398O19.2 3
  • PRO28631 3
  • WGAR9166 3
  • HShisa 3

External Ids for SHISA2 Gene

Previous Symbols for SHISA2 Gene

  • C13orf13
  • TMEM46

Summaries for SHISA2 Gene

GeneCards Summary for SHISA2 Gene

SHISA2 (Shisa Family Member 2) is a Protein Coding gene. An important paralog of this gene is SHISA3.

UniProtKB/Swiss-Prot for SHISA2 Gene

  • Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHISA2 Gene

Genomics for SHISA2 Gene

Genomic Location for SHISA2 Gene

Start:
26,044,597 bp from pter
End:
26,051,060 bp from pter
Size:
6,464 bases
Orientation:
Minus strand

Genomic View for SHISA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SHISA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHISA2 Gene

Regulatory Elements for SHISA2 Gene

Proteins for SHISA2 Gene

  • Protein details for SHISA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWI4-SHSA2_HUMAN
    Recommended name:
    Protein shisa-2 homolog
    Protein Accession:
    Q6UWI4
    Secondary Accessions:
    • B9EH70
    • Q5W0G8

    Protein attributes for SHISA2 Gene

    Size:
    295 amino acids
    Molecular mass:
    31375 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SHISA2 Gene

Proteomics data for SHISA2 Gene at MOPED

Post-translational modifications for SHISA2 Gene

No Post-translational modifications

Other Protein References for SHISA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHISA2 Gene

Domains for SHISA2 Gene

Gene Families for SHISA2 Gene

HGNC:

Protein Domains for SHISA2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SHSA2_HUMAN
Family:
  • Belongs to the shisa family.:
    • Q6UWI4
genes like me logo Genes that share domains with SHISA2: view

Function for SHISA2 Gene

Molecular function for SHISA2 Gene

UniProtKB/Swiss-Prot Function: Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.

Phenotypes for SHISA2 Gene

genes like me logo Genes that share phenotypes with SHISA2: view

Animal Models for SHISA2 Gene

MGI Knock Outs for SHISA2:

miRNA for SHISA2 Gene

miRTarBase miRNAs that target SHISA2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targeting and HOMER Transcription for SHISA2 Gene

Localization for SHISA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHISA2 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SHISA2 Gene COMPARTMENTS Subcellular localization image for SHISA2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SHISA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SHISA2: view

Pathways for SHISA2 Gene

SuperPathways for SHISA2 Gene

No Data Available

Interacting Proteins for SHISA2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000313079%0d%0a9606.ENSP00000325929%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000313079 for SHISA2 Gene via STRING

Gene Ontology (GO) - Biological Process for SHISA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
genes like me logo Genes that share ontologies with SHISA2: view

No data available for Pathways by source for SHISA2 Gene

Transcripts for SHISA2 Gene

mRNA/cDNA for SHISA2 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SHISA2 Gene

Shisa homolog 2 (Xenopus laevis):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SHISA2 Gene

No ASD Table

Relevant External Links for SHISA2 Gene

GeneLoc Exon Structure for
SHISA2
ECgene alternative splicing isoforms for
SHISA2

Expression for SHISA2 Gene

mRNA expression in normal human tissues for SHISA2 Gene

mRNA differential expression in normal tissues according to GTEx for SHISA2 Gene

This gene is overexpressed in Thyroid (10.5) and Muscle - Skeletal (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SHISA2 Gene

SOURCE GeneReport for Unigene cluster for SHISA2 Gene Hs.433791

genes like me logo Genes that share expressions with SHISA2: view

Orthologs for SHISA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SHISA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SHISA2 36
  • 99.21 (n)
  • 99.66 (a)
SHISA2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SHISA2 36
  • 88.72 (n)
  • 94.62 (a)
SHISA2 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SHISA2 36
  • 91.32 (n)
  • 95.09 (a)
SHISA2 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Shisa2 36
  • 86.89 (n)
  • 92.54 (a)
Shisa2 16
Shisa2 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SHISA2 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SHISA2 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Shisa2 36
  • 87.01 (n)
  • 92.54 (a)
chicken
(Gallus gallus)
Aves SHISA2 36
  • 82.38 (n)
  • 88.51 (a)
SHISA2 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SHISA2 37
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68837 36
tropical clawed frog
(Silurana tropicalis)
Amphibia shisa2 36
  • 75.8 (n)
  • 85.1 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100537021 36
  • 66.25 (n)
  • 69.04 (a)
SHISA2 37
  • 56 (a)
OneToOne
Species with no ortholog for SHISA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHISA2 Gene

ENSEMBL:
Gene Tree for SHISA2 (if available)
TreeFam:
Gene Tree for SHISA2 (if available)

Paralogs for SHISA2 Gene

Paralogs for SHISA2 Gene

Selected SIMAP similar genes for SHISA2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SHISA2: view

Variants for SHISA2 Gene

Sequence variations from dbSNP and Humsavar for SHISA2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs1055252 -- 26,044,784(-) CAAAT(C/T)GCTGT utr-variant-3-prime
rs3088377 -- 26,052,491(+) TGTGT(C/T)TGGTG upstream-variant-2KB
rs4769452 -- 26,050,997(+) CGGAC(A/G)GCGCG utr-variant-5-prime
rs4770907 -- 26,049,671(+) TCTCT(C/T)ACGAG intron-variant
rs4770908 -- 26,049,749(+) TCAGG(A/G)TGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SHISA2 Gene

Variant ID Type Subtype PubMed ID
nsv435952 OTHER Inversion 17901297
esv2747161 CNV Deletion 23290073
nsv832569 CNV Loss 17160897

Relevant External Links for SHISA2 Gene

HapMap Linkage Disequilibrium report
SHISA2

Disorders for SHISA2 Gene

Relevant External Links for SHISA2

Genetic Association Database (GAD)
SHISA2
genes like me logo Genes that share disorders with SHISA2: view

No data available for UniProtKB/Swiss-Prot for SHISA2 Gene

Publications for SHISA2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  3. Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. (PMID: 17481602) Furushima K. … Aizawa S. (Dev. Biol. 2007) 3
  4. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3
  5. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PMID: 22889411) Guo Z. … Gao Y. (J. Proteome Res. 2012) 3

Products for SHISA2 Gene

Sources for SHISA2 Gene

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