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Aliases for SHH Gene

Aliases for SHH Gene

  • Sonic Hedgehog 2 3 5
  • Sonic Hedgehog (Drosophila) Homolog 2
  • Sonic Hedgehog Homolog (Drosophila) 2
  • Sonic Hedgehog Homolog 3
  • MCOPCB5 3
  • SMMCI 3
  • TPTPS 3
  • HHG-1 4
  • HHG1 3
  • HLP3 3
  • HPE3 3
  • TPT 3

External Ids for SHH Gene

Previous HGNC Symbols for SHH Gene

  • HPE3
  • HLP3

Previous GeneCards Identifiers for SHH Gene

  • GC07M153825
  • GC07M154898
  • GC07M155013
  • GC07M155014
  • GC07M155095
  • GC07M155288
  • GC07M155592
  • GC07M149327

Summaries for SHH Gene

Entrez Gene Summary for SHH Gene

  • This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. [provided by RefSeq, Jul 2008]

GeneCards Summary for SHH Gene

SHH (Sonic Hedgehog) is a Protein Coding gene. Diseases associated with SHH include single median maxillary central incisor and holoprosencephaly-3. Among its related pathways are Signaling by GPCR and Infectious disease. GO annotations related to this gene include calcium ion binding and glycoprotein binding. An important paralog of this gene is IHH.

UniProtKB/Swiss-Prot for SHH Gene

  • Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO (By similarity).

Tocris Summary for SHH Gene

  • The Hedgehog (Hh) signaling pathway is crucial in the development of all animals. In the embryo, it regulates morphogenesis of a variety of tissues and organs; in the adult, it controls stem cell proliferation. There are three known human Hh proteins: Shh, Dhh and Ihh.

Gene Wiki entry for SHH Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHH Gene

Genomics for SHH Gene

Genomic Location for SHH Gene

Chromosome:
7
Start:
155,799,986 bp from pter
End:
155,812,273 bp from pter
Size:
12,288 bases
Orientation:
Minus strand

Genomic View for SHH Gene

Genes around SHH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHH Gene

Proteins for SHH Gene

  • Protein details for SHH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15465-SHH_HUMAN
    Recommended name:
    Sonic hedgehog protein
    Protein Accession:
    Q15465
    Secondary Accessions:
    • A4D247
    • Q75MC9

    Protein attributes for SHH Gene

    Size:
    462 amino acids
    Molecular mass:
    49607 Da
    Quaternary structure:
    • Interacts with HHATL/GUP1 which negatively regulates HHAT-mediated palmitoylation of the SHH N-terminus. N-product is active as a multimer. Interacts with BOC and CDON (By similarity). Interacts with HHIP.

    Three dimensional structures from OCA and Proteopedia for SHH Gene

neXtProt entry for SHH Gene

Proteomics data for SHH Gene at MOPED

Post-translational modifications for SHH Gene

  • Cholesterylation is required for N-product targeting to lipid rafts and multimerization.
  • N-palmitoylation of Cys-24 by HHAT is required for N-product multimerization and full activity.
  • The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal fragment (N-product). The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity.
  • Glycosylation at Asn 278
  • Modification sites at PhosphoSitePlus

Other Protein References for SHH Gene

Antibody Products

  • R&D Systems Antibodies for SHH (Sonic Hedgehog/Shh)
  • Cell Signaling Technology (CST) Antibodies for SHH (SHH)

Protein Products

No data available for DME Specific Peptides for SHH Gene

Domains & Families for SHH Gene

Suggested Antigen Peptide Sequences for SHH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15465

UniProtKB/Swiss-Prot:

SHH_HUMAN :
  • The sonic hedgehog protein N-product binds calcium and zinc ions; this stabilizes the protein fold and is essential for protein-protein interactions mediated by this domain.
  • Belongs to the hedgehog family.
Domain:
  • The sonic hedgehog protein N-product binds calcium and zinc ions; this stabilizes the protein fold and is essential for protein-protein interactions mediated by this domain.
Family:
  • Belongs to the hedgehog family.
genes like me logo Genes that share domains with SHH: view

No data available for Gene Families for SHH Gene

Function for SHH Gene

Molecular function for SHH Gene

GENATLAS Biochemistry:
embryonic patterning gene,Drosophila segment polarity gene Sonic hedgehog homolog,general ventralizing signal,expressed in the notochord and floor plate cells,gut endoderm,posterior limb buds,inductive signal for somite differentiation and limb development at the anteroposterior axis,targetting BMP2 and HOXD genes through a FGF4 positive feedback loop,also expressed in fetal liver,lung and kidney and in hair follicle,involved in signal transduction,SHH pathway
UniProtKB/Swiss-Prot Function:
Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO (By similarity).

LifeMap Function Summary for SHH Gene

During embryonic development, SHH as signaling molecule is secreted from the following cells
It affects the following cells:
SHH as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for SHH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016015 morphogen activity NAS,TAS 24431302
genes like me logo Genes that share ontologies with SHH: view
genes like me logo Genes that share phenotypes with SHH: view

Human Phenotype Ontology for SHH Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SHH Gene

MGI Knock Outs for SHH:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SHH Gene

Localization for SHH Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHH Gene

Sonic hedgehog protein C-product: Secreted, extracellular space. Note=The C-terminal peptide diffuses from the cell. {ECO:0000250 UniProtKB:Q62226}.
Sonic hedgehog protein N-product: Cell membrane; Lipid-anchor. Note=The N-product either remains associated with lipid rafts at the cell surface, or forms freely diffusible active multimers with its hydrophobic lipid-modified N- and C-termini buried inside. {ECO:0000250 UniProtKB:Q62226}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SHH Gene COMPARTMENTS Subcellular localization image for SHH gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
extracellular 5
plasma membrane 5
cytoskeleton 2
nucleus 2
golgi apparatus 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for SHH Gene

Pathways & Interactions for SHH Gene

genes like me logo Genes that share pathways with SHH: view

SIGNOR curated interactions for SHH Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SHH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0001525 angiogenesis IEA --
GO:0001569 patterning of blood vessels IEA,ISS --
GO:0001570 vasculogenesis IEA,ISS --
GO:0001656 metanephros development IEA,ISS --
genes like me logo Genes that share ontologies with SHH: view

Drugs & Compounds for SHH Gene

(36) Drugs for SHH Gene - From: Novoseek, ApexBio, ClinicalTrials, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum 2540
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 2643
Epinephrine Approved Pharma 834
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 1881
Pemetrexed Approved, Investigational Pharma TS, DHFR,GARFT and AICARFT inhibitor, DHFR and Thymidylate synthase inhibitor, Anti-Folates 580

(3) Additional Compounds for SHH Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
20(S)-Hydroxycholesterol
516-72-3
AY 9944 dihydrochloride
366-93-8
U 18666A
3039-71-2
genes like me logo Genes that share compounds with SHH: view

Drug Products

Transcripts for SHH Gene

mRNA/cDNA for SHH Gene

(6) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SHH Gene

Sonic hedgehog:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SHH Gene

No ASD Table

Relevant External Links for SHH Gene

GeneLoc Exon Structure for
SHH
ECgene alternative splicing isoforms for
SHH

Expression for SHH Gene

mRNA expression in normal human tissues for SHH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SHH Gene

This gene is overexpressed in Liver (x9.8), Bladder (x8.4), Nerve - Tibial (x6.5), and Adrenal Gland (x6.3).

Protein differential expression in normal tissues from HIPED for SHH Gene

This gene is overexpressed in Fetal Liver (26.4), Placenta (24.3), and Peripheral blood mononuclear cells (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SHH Gene



SOURCE GeneReport for Unigene cluster for SHH Gene Hs.164537

mRNA Expression by UniProt/SwissProt for SHH Gene

Q15465-SHH_HUMAN
Tissue specificity: Expressed in fetal intestine, liver, lung, and kidney. Not expressed in adult tissues.
genes like me logo Genes that share expression patterns with SHH: view

Protein tissue co-expression partners for SHH Gene

Primer Products

In Situ Assay Products

Orthologs for SHH Gene

This gene was present in the common ancestor of animals.

Orthologs for SHH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 75 (a)
ManyToMany
SHH 35
  • 99.71 (n)
  • 99.57 (a)
cow
(Bos Taurus)
Mammalia SHH 35
  • 82.68 (n)
  • 81.01 (a)
SHH 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SHH 36
  • 91 (a)
OneToOne
SHH 35
  • 89.15 (n)
  • 91.97 (a)
mouse
(Mus musculus)
Mammalia Shh 16
Shh 36
  • 90 (a)
OneToOne
Shh 35
  • 87.9 (n)
  • 92.79 (a)
oppossum
(Monodelphis domestica)
Mammalia SHH 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 72 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Shh 35
  • 87.02 (n)
  • 92.55 (a)
chicken
(Gallus gallus)
Aves SHH 35
  • 81.17 (n)
  • 85.5 (a)
SHH 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SHH 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398047 35
tropical clawed frog
(Silurana tropicalis)
Amphibia shh 35
  • 67.53 (n)
  • 70.2 (a)
zebrafish
(Danio rerio)
Actinopterygii shh 35
shhb 35
  • 65.3 (n)
  • 71.98 (a)
shha 36
  • 71 (a)
OneToMany
shhb 36
  • 67 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001412 35
  • 60 (n)
  • 54.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta hh 37
  • 45 (a)
hh 35
  • 58.71 (n)
  • 53.43 (a)
hh 36
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
Species with no ortholog for SHH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHH Gene

ENSEMBL:
Gene Tree for SHH (if available)
TreeFam:
Gene Tree for SHH (if available)

Paralogs for SHH Gene

Paralogs for SHH Gene

(2) SIMAP similar genes for SHH Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for SHH Gene

genes like me logo Genes that share paralogs with SHH: view

Variants for SHH Gene

Sequence variations from dbSNP and Humsavar for SHH Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs28936675 Holoprosencephaly 3 (HPE3) 155,812,032(-) GGTTC(A/G)GGAAG reference, missense
VAR_003620 Holoprosencephaly 3 (HPE3)
VAR_003621 Holoprosencephaly 3 (HPE3)
VAR_009163 Holoprosencephaly 3 (HPE3)
VAR_009164 Holoprosencephaly 3 (HPE3)

Structural Variations from Database of Genomic Variants (DGV) for SHH Gene

Variant ID Type Subtype PubMed ID
nsv509227 CNV Insertion 20534489
nsv889560 CNV Loss 21882294
dgv7559n71 CNV Loss 21882294
esv2663062 CNV Deletion 23128226

Variation tolerance for SHH Gene

Residual Variation Intolerance Score: 23.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SHH Gene

HapMap Linkage Disequilibrium report
SHH
Human Gene Mutation Database (HGMD)
SHH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHH Gene

Disorders for SHH Gene

MalaCards: The human disease database

(74) MalaCards diseases for SHH Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
single median maxillary central incisor
  • single upper central incisor
holoprosencephaly-3
  • holoprosencephaly 3
microphthalmia with coloboma 5
  • microphthalmia, isolated, with coloboma, 5
semilobar holoprosencephaly
hypoplastic tibiae-postaxial polydactyly syndrome
  • werner mesomelic syndrome
- elite association - COSMIC cancer census association via MalaCards
Search SHH in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SHH_HUMAN
  • Microphthalmia, isolated, with coloboma, 5 (MCOPCB5) [MIM:611638]: A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities may also be present. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). {ECO:0000269 PubMed:12503095}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Holoprosencephaly 3 (HPE3) [MIM:142945]: A structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. The majority of holoprosencephaly type 3 cases are apparently sporadic, although clear examples of autosomal dominant inheritance have been described. {ECO:0000269 PubMed:10441331, ECO:0000269 PubMed:10556296, ECO:0000269 PubMed:11479728, ECO:0000269 PubMed:15107988, ECO:0000269 PubMed:15221788, ECO:0000269 PubMed:15942952, ECO:0000269 PubMed:15942953, ECO:0000269 PubMed:17001669, ECO:0000269 PubMed:19603532, ECO:0000269 PubMed:8896572, ECO:0000269 PubMed:9302262}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Solitary median maxillary central incisor (SMMCI) [MIM:147250]: Rare dental anomaly characterized by the congenital absence of one maxillary central incisor. {ECO:0000269 PubMed:11471164, ECO:0000269 PubMed:15103725}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Triphalangeal thumb-polysyndactyly syndrome (TPTPS) [MIM:174500]: Autosomal dominant syndrome. It is characterized by a wide spectrum of pre- and post-axial abnormalities due to altered SHH expression pattern during limb development. {ECO:0000269 PubMed:12837695, ECO:0000269 PubMed:18417549}. Note=The gene represented in this entry is involved in disease pathogenesis. Mutations located in intron 5 of LMBR1 disrupt a long-range, cis-regulatory element of SHH expression.
  • Preaxial polydactyly 2 (PPD2) [MIM:174500]: Polydactyly consists of duplication of the distal phalanx. The thumb in PPD2 is usually opposable and possesses a normal metacarpal. {ECO:0000269 PubMed:12837695}. Note=The gene represented in this entry is involved in disease pathogenesis. Mutations located in intron 5 of LMBR1 disrupt a long-range, cis-regulatory element of SHH and result in abnormal, ectopic SHH expression with pathological consequences (PubMed:12837695). {ECO:0000269 PubMed:12837695}.
  • Hypoplasia or aplasia of tibia with polydactyly (THYP) [MIM:188740]: An autosomal dominant disease characterized by hypoplastic or absent tibia, and polydactyly. {ECO:0000269 PubMed:19847792, ECO:0000269 PubMed:24965254}. Note=The gene represented in this entry is involved in disease pathogenesis. Mutations located in intron 5 of LMBR1 disrupt a long-range, cis-regulatory element of SHH and result in abnormal, ectopic SHH expression with pathological consequences. {ECO:0000303 PubMed:19847792, ECO:0000303 PubMed:24965254}.
  • Laurin-Sandrow syndrome (LSS) [MIM:135750]: A rare autosomal dominant disorder characterized by polysyndactyly of hands and/or feet, mirror image duplication of the feet, nasal defects, and loss of identity between fibula and tibia. Some patients do not have nasal abnormalities (segmental Laurin-Sandrow syndrome). {ECO:0000269 PubMed:24456159}. Note=The gene represented in this entry is involved in disease pathogenesis. Abnormal SHH limb expression with pathological consequences is caused by duplications (16-75 kb) involving the ZPA regulatory sequence (ZRS), a SHH long-range cis-regulatory element, located in LMBR1 intron 5 (PubMed:24456159).

Relevant External Links for SHH

Genetic Association Database (GAD)
SHH
Human Genome Epidemiology (HuGE) Navigator
SHH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SHH
genes like me logo Genes that share disorders with SHH: view

No data available for Genatlas for SHH Gene

Publications for SHH Gene

  1. Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog. (PMID: 7590746) Marigo V. … Tabin C. (Genomics 1995) 2 3 4 23 67
  2. Stage-specific role for shh in dopaminergic differentiation of human embryonic stem cells induced by stromal cells. (PMID: 19788370) Swistowska A.M. … Zeng X. (Stem Cells Dev. 2010) 3 23
  3. Distinct expression patterns of hedgehog ligands between cultured and primary colorectal cancers are associated with aberrant methylation of their promoters. (PMID: 19856079) Fu X. … Zhang Y. (Mol. Cell. Biochem. 2010) 3 23
  4. Oestrogen receptor-alpha contributes to the regulation of the hedgehog signalling pathway in ERalpha-positive gastric cancer. (PMID: 20087349) Kameda C. … Katano M. (Br. J. Cancer 2010) 3 23
  5. Array-CGH analysis indicates a high prevalence of genomic rearrangements in holoprosencephaly: an updated map of candidate loci. (PMID: 19431187) Bendavid C. … David V. (Hum. Mutat. 2009) 3 23

Products for SHH Gene

  • Addgene plasmids for SHH

Sources for SHH Gene

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