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SHFM1 Gene

protein-coding   GIFtS: 58
GCID: GC07M096156

Split Hand/Foot Malformation (Ectrodactyly) Type 1


(Previous symbol: SHFD1)
  See SHFM1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Split Hand/Foot Malformation (Ectrodactyly) Type 11 2     26S Proteasome Complex Subunit DSS12
DSS12 3 5     ECD2
SHFD11 2     SEM12
Deleted In Split Hand/Split Foot Protein 12 3     SHSF12
Split Hand/Foot Deleted Protein 12 3     Shfdg12
Split Hand/Foot Malformation Type 1 Protein2 3     Deleted In Split-Hand/Split-Foot 12
Deleted In Split-Hand/Foot 11     SHFDG13

External Ids:    HGNC: 108451   Entrez Gene: 79792   Ensembl: ENSG000001279227   OMIM: 6012855   UniProtKB: P608963   

Export aliases for SHFM1 gene to outside databases

Previous GC identifers: GC07U990090 GC07M095713 GC07M095929 GC07M095962 GC07M090925


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SHFM1 Gene:
The product of this gene has been localized within the split hand/split foot malformation locus SHFM1 at
chromosome 7. It has been proposed to be a candidate gene for the autosomal dominant form of the heterogeneous
limb developmental disorder split hand/split foot malformation type 1. In addition, it has been shown to directly
interact with BRCA2. It also may play a role in the completion of the cell cycle. (provided by RefSeq, Jul 2008)

GeneCards Summary for SHFM1 Gene:
SHFM1 (split hand/foot malformation (ectrodactyly) type 1) is a protein-coding gene. Diseases associated with SHFM1 include ovarian mucinous adenofibroma, and split hand. GO annotations related to this gene include peptidase activity.

UniProtKB/Swiss-Prot: DSS1_HUMAN, P60896
Function: Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis

Gene Wiki entry for SHFM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SHFM1 gene promoter:
         Pbx1a   AML1a   Tal-1beta   POU2F1   FOXC1   E2F   E2F-1   POU2F1a   ITF-2   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SHFM1 promoter sequence
   Search Chromatin IP Primers for SHFM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SHFM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.3   Ensembl cytogenetic band:  7q21.3   HGNC cytogenetic band: 7q21.3

SHFM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHFM1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M096156:  view genomic region     (about GC identifiers)

Start:
96,110,938 bp from pter      End:
96,339,203 bp from pter
Size:
228,266 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 95,646,961-95,668,081     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DSS1_HUMAN, P60896 (See protein sequence)
Recommended Name: 26S proteasome complex subunit DSS1  
Size: 70 amino acids; 8278 Da
Subunit: Part of the 26S proteasome. Interacts with the C-terminal of BRCA2
4 PDB 3D structures from and Proteopedia for SHFM1:
1IYJ (3D)        1MIU (3D)        1MJE (3D)        3T5X (3D)    
Secondary accessions: Q13437 Q61067

Explore the universe of human proteins at neXtProt for SHFM1: NX_P60896

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins: NP_006295.1  
    ENSEMBL proteins: 
     ENSP00000416322   ENSP00000390049   ENSP00000392852   ENSP00000409481   ENSP00000248566  

    SHFM1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SHFM1

     
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    Search eBioscience for ELISAs for SHFM1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007834 DSS1_SEM1

    Graphical View of Domain Structure for InterPro Entry P60896

    ProtoNet protein and cluster: P60896

    UniProtKB/Swiss-Prot: DSS1_HUMAN, P60896
    Similarity: Belongs to the DSS1/SEM1 family


    Find genes that share domains with SHFM1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DSS1_HUMAN, P60896
    Function: Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10373512
    GO:0008233peptidase activity IDA10373512
         
    Find genes that share ontologies with SHFM1           About GenesLikeMe


    Phenotypes:
         9 GenomeRNAi human phenotypes for SHFM1:
     Decreased POU5F1-GFP protein e  Decreased homologous recombina  Decreased melanin production  Decreased viability with cispl 
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  G0/1 arrest  Increased G1 DNA content 
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SHFM1
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    miRNA
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    miRTarBase miRNAs that target SHFM1:
    hsa-mir-30c-5p (MIRT047956), hsa-mir-26b-5p (MIRT029635)

    Block miRNA regulation of human, mouse, rat SHFM1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SHFM1
    SwitchGear 3'UTR luciferase reporter plasmidSHFM1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    nucleus2
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex IDA15117943
    GO:0032039colocalizes with integrator complex IDA16239144

    Find genes that share ontologies with SHFM1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SHFM1 About    
    See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    Proteasome0.79
    2Homologous recombination
    Homologous recombination0.40
    3Epstein-Barr virus infection
    Epstein-Barr virus infection


    Find genes that share SuperPaths with SHFM1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3 Kegg Pathways  (Kegg details for SHFM1):
        Proteasome
    Homologous recombination
    Epstein-Barr virus infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SHFM1
    Interactions:

        GeneGlobe Interaction Network for SHFM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SHFM1 (P608961, 2, 3 ENSP000002485664) via UniProtKB, MINT, STRING, and/or I2D (see all 168)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3BQ9GZQ82, 3MINT-8259756 I2D: score=2 
    BRCA2P515871, 2, 3, ENSP000003694974EBI-79819,EBI-79792 MINT-8392663 I2D: score=5 STRING: ENSP00000369497
    NUDT21O438092, 3, ENSP000003002914MINT-8264545 I2D: score=2 STRING: ENSP00000300291
    PSMD6Q150083, ENSP000002959014I2D: score=1 STRING: ENSP00000295901
    PCID2Q5JVF33, ENSP000003374054I2D: score=3 STRING: ENSP00000337405
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    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000724double-strand break repair via homologous recombination IEA--
    GO:0006508proteolysis IDA10373512

    Find genes that share ontologies with SHFM1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SHFM1 (DSS1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SHFM1 gene: 
    NM_006304.1  

    Unigene Cluster for SHFM1:

    Split hand/foot malformation (ectrodactyly) type 1
    Hs.489201  [show with all ESTs]
    Unigene Representative Sequence: AK094899
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493858 ENST00000466986 ENST00000417009(uc010lfm.2) ENST00000444799
    ENST00000449279 ENST00000488005(uc010lfn.1) ENST00000413065 ENST00000248566(uc003uoi.3)
    ENST00000482389 ENST00000476463
    miRNA
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    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for SHFM1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SHFM1
      QuantiTect SYBR Green Assays in human, mouse, rat SHFM1
      QuantiFast Probe-based Assays in human, mouse, rat SHFM1

    Additional mRNA sequence: 

    AK094899.1 AK291070.1 AK309241.1 BC032782.1 CR456887.1 U41515.1 

    20 DOTS entries:

    DT.448783  DT.40302008  DT.91705166  DT.100802998  DT.100802999  DT.91762021  DT.101981825  DT.95072359 
    DT.120884816  DT.100802992  DT.100802993  DT.91762012  DT.95178404  DT.100034918  DT.100803000  DT.121055921 
    DT.121055941  DT.121055957  DT.95072350  DT.218198 

    Selected AceView cDNA sequences (see all 288):

    BM840691 AV682716 AA508831 BQ668839 NM_207503 AA778807 AW470613 AA779301 
    AW070973 BM794634 BE792618 BM852431 AI929403 BM048013 CB177363 BM972698 
    W74470 BQ549345 U41515 AW157196 AA181213 BC032782 AI929447 BG114538 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SHFM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTATAAGAT
    SHFM1 Expression
    About this image


    SHFM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Lung (Respiratory System)
             Trachea
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Kidney (Urinary System)
             Metanephros
    SHFM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.489201

    UniProtKB/Swiss-Prot: DSS1_HUMAN, P60896
    Tissue specificity: Expressed in limb bud, craniofacial primordia and skin

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SHFM1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Shfm11 , 5 split hand/foot malformation (ectrodactyly) type 11, 5 88.57(n)1
    100(a)1
      6 (2.59 cM)5
    204221  NM_009169.21  NP_033195.11 
     65572945 
    chicken
    (Gallus gallus)
    Aves SHFM11 split hand/foot malformation (ectrodactyly) type 1 85.71(n)
    98.57(a)
      772237  NM_001085439.1  NP_001078908.1 
    lizard
    (Anolis carolinensis)
    Reptilia SHFM16
    split hand/foot malformation (ectrodactyly) type 1...
    100(a)
    1 ↔ 1
    6(23063441-23072452)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL856361.22   -- 85(n)    AL856361.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb55c022 wufb55c02 79.44(n)   322269  BC050505.1 


    ENSEMBL Gene Tree for SHFM1 (if available)
    TreeFam Gene Tree for SHFM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SHFM1 (see all 493)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs678922731,2
    C--90943737(+) AAAAA-/A/AA  
      AAAAAA
    AAAAA
    1 -- int11NA 2
    rs106246031,2
    C--95656620(+) acccc-/CTgacag 1 -- int10--------
    rs1137934691,2
    F--95656685(+) ACTCCC/AAGTTA 1 -- int12Minor allele frequency- A:0.50CSA 4
    rs745872691,2
    C--95656768(-) AGGGAC/TATGGA 1 -- int13Minor allele frequency- T:0.00NA 6
    rs608668341,2
    C--96326483(+) AAAAA-/ACCCTA 1 -- int10--------
    rs3713847631,2
    C--96331564(+) TACAT-/ACACACA 1 -- int10--------
    rs671747981,2
    C--96333285(+) TAAAA-/ACACAC
            
    ACACA
    1 -- int10--------
    rs711274651,2
    C--96333287(-) ATGTA-/TGTG/T
    GTGTGTGTG
    TGTGT
    1 -- int11NA 2
    rs345253271,2
    C--96334671(+) CTCTC-/A/AA  
            
    AAAAA
    1 -- int11NA 2
    rs356800541,2
    C--96334672(+) AAAAA-/AACCCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for SHFM1 (96110938 - 96339203 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SHFM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831065CNV Gain17160897
    nsv888756CNV Gain21882294

    Human Gene Mutation Database (HGMD): SHFM1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SHFM1
    DNA2.0 Custom Variant and Variant Library Synthesis for SHFM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601285    OMIM disorders: --

    9 diseases for SHFM1:    
    About MalaCards
    ovarian mucinous adenofibroma    split hand    split hand foot malformation 1    skin squamous cell carcinoma
    mucinous adenofibroma    adenofibroma    split foot    split-hand/foot malformation 6
    male breast cancer

    5 diseases from the University of Copenhagen DISEASES database for SHFM1:
    Ovarian mucinous adenofibroma     Hypothyroidism     Hepatitis B     Syndactyly
    Hepatitis A

    Find genes that share disorders with SHFM1           About GenesLikeMe

    Genetic Association Database (GAD): SHFM1
    Human Genome Epidemiology (HuGE) Navigator: SHFM1 (7 documents)

    Export disorders for SHFM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SHFM1 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with SHFM1)
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    1. Characterization of the split hand/split foot malformation locus SHFM1 at 7q21.3-q22.1 and analysis of a candidate gene for its expression during limb development. (PubMed id 8733122)1, 2, 3 Crackower M.A.... Tsui L.-C. (Hum. Mol. Genet. 1996)
    2. Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. (PubMed id 20694011)1, 4 Ferreira R.C....HammarstrAPm L. (Nat. Genet. 2010)
    3. Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk. (PubMed id 20610542)1, 4 Liu Y....Bondy M.L. (Carcinogenesis 2010)
    4. Association of the DSS1 c.143G&gt;A polymorphism with skin squamous cell carcinoma. (PubMed id 20220765)1, 4 Venza M....Teti D. (J. Invest. Dermatol. 2010)
    5. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
    6. Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. (PubMed id 19690177)1, 4 McWilliams R.R....Petersen G.M. (amp 2009)
    7. Sem1p is a novel subunit of the 26S proteasome from Saccharomyces cerevisiae. (PubMed id 15117943)1, 2 Sone T.... Yokosawa H. (J. Biol. Chem. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    10. BRCA2 function in DNA binding and recombination from a BRCA2-DSS1- ssDNA structure. (PubMed id 12228710)1, 2 Yang H.... Pavletich N.P. (Science 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7979 HGNC: 10845 AceView: SHFM1andFLJ42280 Ensembl:ENSG00000127922 euGenes: HUgn7979
    ECgene: SHFM1 Kegg: 7979 H-InvDB: SHFM1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SHFM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SHFM1 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/gtr/tests/503057/

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SHFM1 gene:
    Search GeneIP for patents involving SHFM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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