Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SHF Gene

Aliases for SHF Gene

  • Src Homology 2 Domain Containing F 2 3
  • SHFD2 6
  • SHFM2 6

External Ids for SHF Gene

Previous GeneCards Identifiers for SHF Gene

  • GC15M043247
  • GC15M045459
  • GC15M022283

Summaries for SHF Gene

GeneCards Summary for SHF Gene

SHF (Src Homology 2 Domain Containing F) is a Protein Coding gene. Among its related pathways are PDGFR-alpha signaling pathway. An important paralog of this gene is SHB.

UniProtKB/Swiss-Prot for SHF Gene

  • Adapter protein which may play a role in the regulation of apoptosis in response to PDGF.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHF Gene

Genomics for SHF Gene

Regulatory Elements for SHF Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SHF Gene

45,167,214 bp from pter
45,201,175 bp from pter
33,962 bases
Minus strand

Genomic View for SHF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SHF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHF Gene

Proteins for SHF Gene

  • Protein details for SHF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH2 domain-containing adapter protein F
    Protein Accession:
    Secondary Accessions:
    • Q96IE8

    Protein attributes for SHF Gene

    423 amino acids
    Molecular mass:
    46768 Da
    Quaternary structure:
    • Interacts with phosphorylated Tyr-720 of PDGFRA via its SH2 domain.
    • The sequence described in PubMed:11095946 is over-extended by 57 aa at the N-terminus due to the presence of an uncorrected 5 mismatch compared to the reference genome sequence

    Alternative splice isoforms for SHF Gene


neXtProt entry for SHF Gene

Proteomics data for SHF Gene at MOPED

Post-translational modifications for SHF Gene

Antibody Products

No data available for DME Specific Peptides for SHF Gene

Domains for SHF Gene

Gene Families for SHF Gene

Protein Domains for SHF Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SH2 domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SHF: view

Function for SHF Gene

Molecular function for SHF Gene

UniProtKB/Swiss-Prot Function:
Adapter protein which may play a role in the regulation of apoptosis in response to PDGF.

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SHF Gene

Localization for SHF Gene

Subcellular locations from

Jensen Localization Image for SHF Gene COMPARTMENTS Subcellular localization image for SHF gene
Compartment Confidence
cytosol 3
nucleus 3
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SHF Gene

Pathways for SHF Gene

SuperPathways for SHF Gene

genes like me logo Genes that share pathways with SHF: view

Pathways by source for SHF Gene

1 BioSystems pathway for SHF Gene

Interacting Proteins for SHF Gene

Gene Ontology (GO) - Biological Process for SHF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with SHF: view

Transcripts for SHF Gene

Unigene Clusters for SHF Gene

Src homology 2 domain containing F:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SHF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g ^ 9 ^ 10a · 10b
SP1: - - - - - -
SP2: -
SP3: - - -
SP4: - - - - - - -
SP6: - - - - - -
SP7: - - -
SP8: - - - - -

Relevant External Links for SHF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SHF Gene

mRNA expression in normal human tissues for SHF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SHF Gene

This gene is overexpressed in Brain - Cerebellum (10.4) and Brain - Cerebellar Hemisphere (10.0).

Protein differential expression in normal tissues for SHF Gene

This gene is overexpressed in Heart (46.1) and Fetal Brain (22.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SHF Gene

SOURCE GeneReport for Unigene cluster for SHF Gene Hs.310399

mRNA Expression by UniProt/SwissProt for SHF Gene

Tissue specificity: Expressed in skeletal muscle, brain, liver, prostate, testis, ovary, small intestine and colon.
genes like me logo Genes that share expressions with SHF: view

Expression partners for SHF Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for SHF Gene

This gene was present in the common ancestor of animals.

Orthologs for SHF Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SHF 35
  • 94.52 (n)
  • 97.55 (a)
SHF 36
  • 78 (a)
(Canis familiaris)
Mammalia SHF 35
  • 94.41 (n)
  • 97.52 (a)
SHF 36
  • 55 (a)
(Mus musculus)
Mammalia Shf 35
  • 92.72 (n)
  • 96.64 (a)
Shf 16
Shf 36
  • 96 (a)
(Pan troglodytes)
Mammalia SHF 35
  • 99.29 (n)
  • 99.29 (a)
SHF 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Shf 35
  • 93.12 (n)
  • 96.15 (a)
(Monodelphis domestica)
Mammalia SHF 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia SHF 36
  • 87 (a)
(Gallus gallus)
Aves SHF 35
  • 71.77 (n)
  • 72.81 (a)
SHF 36
  • 72 (a)
(Anolis carolinensis)
Reptilia SHF 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia shf 35
  • 70.23 (n)
  • 74.17 (a)
(Danio rerio)
Actinopterygii si:ch73-116f3.3 35
  • 66.04 (n)
  • 70.83 (a)
SHF 36
  • 76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43921 36
  • 6 (a)
Species with no ortholog for SHF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHF Gene

Gene Tree for SHF (if available)
Gene Tree for SHF (if available)

Paralogs for SHF Gene

Paralogs for SHF Gene Pseudogenes for SHF Gene

genes like me logo Genes that share paralogs with SHF: view

Variants for SHF Gene

Sequence variations from dbSNP and Humsavar for SHF Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs732622 -- 45,184,543(-) TAACA(C/T)GGACA intron-variant
rs753414 -- 45,182,173(+) CCCTG(A/C)CCCCC intron-variant, upstream-variant-2KB
rs1611896 -- 45,184,321(+) GAGGA(C/T)CCAAG intron-variant
rs1620253 -- 45,180,512(+) AGGAA(A/G)AAGTC intron-variant
rs1625404 -- 45,181,145(+) CCTCC(C/G)AGGCT intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SHF Gene

Variant ID Type Subtype PubMed ID
nsv518213 CNV Gain 19592680
nsv904187 CNV Loss 21882294

Relevant External Links for SHF Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHF Gene

Disorders for SHF Gene

(1) University of Copenhagen DISEASES for SHF Gene

Relevant External Links for SHF

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with SHF: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for SHF Gene

Publications for SHF Gene

  1. Shf, a Shb-like adapter protein, is involved in PDGF-alpha-receptor regulation of apoptosis. (PMID: 11095946) Lindholm C.K. … Welsh M. (Biochem. Biophys. Res. Commun. 2000) 2 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  5. Novel adaptor protein Shf interacts with ALK receptor and negatively regulates its downstream signals in neuroblastoma. (PMID: 23360421) Takagi D. … Nakagawara A. (Cancer Sci. 2013) 3

Products for SHF Gene

Sources for SHF Gene

Back to Top