SHF Gene
protein-coding GIFtS : 46
GCID: GC15 M045459
Src homology 2 domain containing F
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Aliasesfor SHF gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Src Homology 2 Domain Containing F 1 2 SH2 Domain-Containing Adapter Protein F2
Export aliases for SHF gene to outside databases Previous GC identifers: GC15M043247 GC15M022283
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Summariesfor SHF gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: SHF_HUMAN, Q7M4L6 Function : Adapter protein which may play a role in the regulation of apoptosis in response to PDGF
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Genomic Viewsfor SHF gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000015.9 NC_018926.1 NT_010194.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SHF gene promoter: LHX3b/Lhx3b RP58 p53 Egr-1 CUTL1 MIF-1 Nkx2-5 POU2F1 POU2F1a LHX3a/Lhx3a Other transcription factors Search SABiosciences Chromatin IP Primers for SHF Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SHF
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 15q21.1 Ensembl cytogenetic band: 15q21.1 HGNC cytogenetic band: 15q21.1 SHF Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 15 GeneLoc Exon Structure
GeneLoc location for GC15M045459: view genomic region
(about GC identifiers )
Start:
45,459,412 bp from pter
End:
45,493,373 bp from pter
Size:
33,962 bases
Orientation:
minus strand
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Proteinsfor SHF gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SHF_HUMAN, Q7M4L6 (See
protein sequence )Recommended Name: SH2 domain-containing adapter protein F Size : 423 amino acids; 46768 Da
Subunit : Interacts with phosphorylated 'Tyr-720' of PDGFRA via its SH2 domain
Miscellaneous : The sequence described in PubMed:11095946 is over-extended by 57 aa at the N-terminus due to thepresence of an uncorrected 5' mismatch compared to the reference genome sequence
Secondary accessions : Q96IE8Alternative splicing : 2 isoforms : Q7M4L6-1 Q7M4L6-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SHF: NX_Q7M4L6 Post-translational modifications:
May become phosphorylated upon binding to PDGFRA1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q7M4L6 SHF Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_612365.2 ENSEMBL proteins: ENSP00000453370 ENSP00000290894 ENSP00000453168 ENSP00000453669 ENSP00000411530 ENSP00000454034 ENSP00000453676 ENSP00000453260 ENSP00000452726 ENSP00000453827 ENSP00000453986 ENSP00000315978 Human Recombinant Protein Products: SHF Antibody Products: Assay Products for SHF:
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Protein
Domains / Familiesfor SHF gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SHF for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q7M4L6 ProtoNet protein and cluster: Q7M4L6
1 Blocks protein family : IPB000980 SH2 domain signature UniProtKB/Swiss-Prot: SHF_HUMAN, Q7M4L6 Similarity : Contains 1 SH2 domain
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Functionfor SHF gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: SHF_HUMAN, Q7M4L6 Function : Adapter protein which may play a role in the regulation of apoptosis in response to PDGF
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SHF (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SHFOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript Custom all cDNA clones Services for SHF Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SHF Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SHF
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHF
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Pathways & Interactionsfor SHF gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 PDGFR-alpha signaling pathway
1 BioSystems Pathway for SHF Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SHF STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for SHF (ENSP00000290894 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006915 apoptotic process
IEA --
SHF for ontologies About GeneDecksing
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Drugs & Compoundsfor SHF gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SHF Search CenterWatch for drugs/clinical trials and news about SHF
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Transcriptsfor SHF gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SHF gene: NM_138356.2 Unigene Cluster for SHF:
Src homology 2 domain containing F Hs.310399 [show with all ESTs ] Unigene Representative Sequence: NM_138356 13 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000560540 (uc010ueo.2 ) ENST00000290894 (uc010uen.2 uc001zuy.3 )ENST00000560734 ENST00000560413 ENST00000458022 ENST00000558294 ENST00000561239 ENST00000560471 (uc010ues.1 uc010uet.1 uc010ueu.2 ) ENST00000559566 ENST00000558685 ENST00000561091 ENST00000561278 ENST00000318390 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SHF (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SHFOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript Custom all cDNA clones Services for SHF DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SHF Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SHF
Additional cDNA sequence: AK096267.1 AK301625.1 AK303749.1 BC007586.1 BC101601.1 BC101603.1 BC143601.1 BC171730.1
12 DOTS entries : DT.408131 DT.95324355
DT.100746226 DT.100745034 DT.101955847 DT.100688005 DT.40131908 DT.432600 DT.75154511 DT.97825673 DT.97826029 DT.97824199 24/79 AceView cDNA sequences (see all 79 ):
BM727200 CR607464 CR597455 BM669861 CR613819 BM673643 CR626127 CR610652 CR604168 AA322771 NM_138356 BM712160 AK094391 BU727555 F13153 BF445569 BX332805 BX446025 BC007586 BX352799 CA335156 BM715118 BI915484 AI768068 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SHF (see all 8 ) About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g ^ 9 ^ 10a · 10b SP1 :     -                 -         -   -   -   -       SP2 :                     -                     SP3 :             -   -       -                     SP4 :             -   -       -         -   -   -   -       SP5 :                                        
ECgene alternative splicing isoforms for SHF
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Expression for SHF gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SHF expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TCCCTGCTCT
About this image SHF expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 2 LifeMap In Vivo Development Anatomical Compartments/Cells Tissue Anatomical Compartment
Cell Category (developmental path) Brain Cerebral Cortex Brain Neural Tube Metencephalon Neural Tube Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See SHF Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SHF SOURCE GeneReport for Unigene cluster: Hs.310399 UniProtKB/Swiss-Prot: SHF_HUMAN, Q7M4L6 Tissue specificity : Expressed in skeletal muscle, brain, liver, prostate, testis, ovary, small intestine and colon SABiosciences Custom PCR Arrays for SHF Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SHFBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SHF QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SHF QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SHF In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHF
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Orthologsfor SHF gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for SHF gene from 5/16 species (see all 16 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
SHF1
Src homology 2 domain containing F
67.6(n) 67.13(a)
 
415339 XM_413725.2 XP_413725.2
lizard (Anolis carolinensis)
Reptilia
SHF6
--
57(a)
1 ↔ 1
GL343490.1(81198-85047)
African clawed frog (Xenopus laevis)
Amphibia
BJ072127.12
--
80.95(n)
 
BJ072127.1
zebrafish (Danio rerio)
Actinopterygii
si:ch73-116f3.36
si:ch73-116f3.3
76(a)
1 ↔ 1
18(49390432-49514397)
fruit fly (Drosophila melanogaster)
Insecta
CG439216
--
5(a)
1 → many
X(12410667-12462394)
ENSEMBL Gene Tree for SHF (if available)TreeFam Gene Tree for SHF (if available)
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Paralogsfor SHF gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SHF gene SHE 2 ENSG00000255872 2 SHD 2 SHB 2 4 SIMAP similar genes for SHF using alignment to 16 protein entries: SHF_HUMAN (see all proteins ):SHB PTPN11 SHE SHD
SHF for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for SHF PGOHUM00000262061
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Genomic Variantsfor SHF gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 15 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for SHF (45459412 - 45493373 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for SHF: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SHF
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Disorders
/ Diseasesfor SHF gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
SHF for disorders About GeneDecksing 5 diseases for SHF : About MalaCards otitis externa diastolic heart failure systolic heart failure echinococcosis prostatitis 2 diseases from the University of Copenhagen DISEASES database for SHF :Congestive heart failure Otitis externa Export disorders for SHF gene to outside databases
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Publicationsfor SHF gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SHF gene integrated from 9 sources : (articles sorted by number of sources associating them with SHF) Utopia : connect your pdf to the dynamic world of online information
Shf, a Shb-like adapter protein, is involved in PDGF-alpha-receptor regulation of apoptosis. (PubMed id 11095946) 1 , 2 , 3 Lindholm C.K.... Welsh M. (2000) Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171) 2 Zody M.C....Nusbaum C. (2006) Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197) 1 Brandenberger R.... Stanton L.W. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548) 1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for SHF gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SHF gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SHF gene
(According to HUGE )
About This Section --
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Specialized Databases showing SHF gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for SHF Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for SHF gene: Search GeneIP for patents involving SHF GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SHF gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for SHF OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SHF OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SHF OriGene Protein Over-expression Lysate for SHF Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SHF Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SHF OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SHF Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for SHF OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SHF OriGene Custom Protein Services for SHF OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SHF QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SHF QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SHF QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SHF QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SHF QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SHF
Search Tocris compounds for SHF
SHF Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHF
Search ThermoFisher Antibodies for SHF
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SHF
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Aliases for SHF
Databases for SHF
Disorders / Diseases for SHF
Domains / Families for SHF
Drugs / Compounds for SHF
Expression for SHF
Function for SHF
Genomic Views for SHF
Intellectual Property for SHF
Orthologs for SHF
Paralogs for SHF
Pathways / Interactions for SHF
Products for SHF
Proteins for SHF
Publications for SHF
Search Box for SHF
Summaries for SHF
Transcripts for SHF
Variants for SHF
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