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SHF Gene

protein-coding   GIFtS: 49
GCID: GC15M045459

Src Homology 2 Domain Containing F

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Src Homology 2 Domain Containing F1 2
SH2 Domain-Containing Adapter Protein F2
SHFD25
SHFM25

External Ids:    HGNC: 251161   Entrez Gene: 905252   Ensembl: ENSG000001386067   OMIM: 3133505   UniProtKB: Q7M4L63   

Export aliases for SHF gene to outside databases

Previous GC identifers: GC15M043247 GC15M022283


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SHF Gene:
SHF (Src homology 2 domain containing F) is a protein-coding gene. Diseases associated with SHF include otitis externa, and diastolic heart failure. An important paralog of this gene is SHE.

UniProtKB/Swiss-Prot: SHF_HUMAN, Q7M4L6
Function: Adapter protein which may play a role in the regulation of apoptosis in response to PDGF




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SHF gene promoter:
         LHX3b/Lhx3b   RP58   p53   Egr-1   CUTL1   MIF-1   Nkx2-5   POU2F1   POU2F1a   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSHF promoter sequence
   Search Chromatin IP Primers for SHF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SHF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.1   Ensembl cytogenetic band:  15q21.1   HGNC cytogenetic band: 15q21.1

SHF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHF gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M045459:  view genomic region     (about GC identifiers)

Start:
45,459,412 bp from pter      End:
45,493,373 bp from pter
Size:
33,962 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SHF_HUMAN, Q7M4L6 (See protein sequence)
Recommended Name: SH2 domain-containing adapter protein F  
Size: 423 amino acids; 46768 Da
Subunit: Interacts with phosphorylated 'Tyr-720' of PDGFRA via its SH2 domain
Miscellaneous: The sequence described in PubMed:11095946 is over-extended by 57 aa at the N-terminus due to the
presence of an uncorrected 5' mismatch compared to the reference genome sequence
Secondary accessions: Q96IE8
Alternative splicing: 2 isoforms:  Q7M4L6-1   Q7M4L6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SHF: NX_Q7M4L6

Explore proteomics data for SHF at MOPED

Post-translational modifications: 

  • May become phosphorylated upon binding to PDGFRA1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SHF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_612365.2  
    ENSEMBL proteins: 
     ENSP00000453370   ENSP00000290894   ENSP00000453168   ENSP00000411530   ENSP00000454034  
     ENSP00000453676   ENSP00000453260   ENSP00000452726   ENSP00000453827   ENSP00000453986  
     ENSP00000315978  

    SHF Human Recombinant Protein Products:

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    Novus Biologicals SHF Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for SHF

    SHF Antibody Products:

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    Novus Biologicals SHF Antibodies
    Abcam antibodies for SHF
    Cloud-Clone Corp. Antibodies for SHF
    ThermoFisher Antibodies for SHF
    LSBio Antibodies in human, mouse, rat for SHF

    SHF Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for SHF
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SHF
    Cloud-Clone Corp. CLIAs for SHF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    1 InterPro protein domain:
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q7M4L6

    ProtoNet protein and cluster: Q7M4L6

    1 Blocks protein domain: IPB000980 SH2 domain signature

    UniProtKB/Swiss-Prot: SHF_HUMAN, Q7M4L6
    Similarity: Contains 1 SH2 domain


    SHF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SHF_HUMAN, Q7M4L6
    Function: Adapter protein which may play a role in the regulation of apoptosis in response to PDGF

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    SHF for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SHF
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SHF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SHF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SHF

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SHF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SHF (see all 11):
    hsa-miR-3140-3p hsa-miR-128 hsa-miR-3681* hsa-miR-1203 hsa-miR-766 hsa-miR-3922-3p hsa-miR-3667-3p hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidSHF 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SHF
    Predesigned siRNA for gene silencing in human, mouse, rat SHF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SHF

    Clone
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    OriGene clones in human, mouse for SHF (see all 5)
    OriGene ORF clones in mouse, rat for SHF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for SHF
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SHF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHF

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SHF 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    extracellular1
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SHF About                                                                                                See pathways by source

    SuperPathContained pathways About
    1PDGFR-alpha signaling pathway
    PDGFR-alpha signaling pathway


    1 BioSystems Pathway for SHF
        PDGFR-alpha signaling pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SHF
    Interactions:

        Search GeneGlobe Interaction Network for SHF

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SHF (ENSP000002908944) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDGFRAENSP000002572904STRING: ENSP00000257290
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--

    SHF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SHF



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SHF gene: 
    NM_138356.2  

    Unigene Cluster for SHF:

    Src homology 2 domain containing F
    Hs.310399  [show with all ESTs]
    Unigene Representative Sequence: NM_138356
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000560540(uc010ueo.2) ENST00000290894(uc010uen.2 uc001zuy.3)
    ENST00000560734 ENST00000458022 ENST00000558294 ENST00000561239 ENST00000560471(uc010ues.1 uc010uet.1 uc010ueu.2)
    ENST00000559566 ENST00000558685 ENST00000561091 ENST00000561278 ENST00000318390

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SHF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SHF (see all 11):
    hsa-miR-3140-3p hsa-miR-128 hsa-miR-3681* hsa-miR-1203 hsa-miR-766 hsa-miR-3922-3p hsa-miR-3667-3p hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidSHF 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SHF
    Predesigned siRNA for gene silencing in human, mouse, rat SHF
    Clone
    Products:
         
    OriGene clones in human, mouse for SHF (see all 5)
    OriGene ORF clones in mouse, rat for SHF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for SHF
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SHF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHF
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SHF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SHF
      QuantiTect SYBR Green Assays in human, mouse, rat SHF
      QuantiFast Probe-based Assays in human, mouse, rat SHF

    Additional mRNA sequence: 

    AK096267.1 AK301625.1 AK303749.1 BC007586.1 BC101601.1 BC101603.1 BC143601.1 BC171730.1 

    12 DOTS entries:

    DT.408131  DT.95324355  DT.100746226  DT.100745034  DT.101955847  DT.100688005  DT.40131908  DT.432600 
    DT.75154511  DT.97825673  DT.97826029  DT.97824199 

    Selected AceView cDNA sequences (see all 79):

    BM727200 CR597455 CR604168 BM712160 CR610652 BM673643 CR613819 CR626127 
    BF445569 AK094391 BU727555 BM669861 F13153 NM_138356 AA322771 CR607464 
    BM665833 BX446025 BC007586 BI915484 BM984257 AW157106 BM715118 BM681670 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SHF (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g ^ 9 ^ 10a · 10b
    SP1:              -                                               -                       -     -     -     -               
    SP2:                                                              -                                                         
    SP3:                                      -     -                 -                                                         
    SP4:                                      -     -                 -                       -     -     -     -               
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for SHF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SHF expression in normal human tissues (normalized intensities)      SHF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCTGCTCT
    SHF Expression
    About this image


    SHF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
    SHF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SHF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.310399

    UniProtKB/Swiss-Prot: SHF_HUMAN, Q7M4L6
    Tissue specificity: Expressed in skeletal muscle, brain, liver, prostate, testis, ovary, small intestine and colon

        Custom PCR Arrays for SHF
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SHF gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Shf1 , 5 Src homology 2 domain containing F1, 5 92.72(n)1
    96.64(a)1
      2 (60.63 cM)5
    4356841  NM_001013829.21  NP_001013851.21 
     1223488925 
    chicken
    (Gallus gallus)
    Aves SHF1 Src homology 2 domain containing F 71.77(n)
    72.81(a)
      415339  XM_413725.3  XP_413725.3 
    lizard
    (Anolis carolinensis)
    Reptilia SHF6
    Src homology 2 domain containing F
    50(a)
    1 ↔ 1
    GL343490.1(79865-85120)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ072127.12   -- 80.95(n)    BJ072127.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-116f3.31 si:ch73-116f3.3 66.04(n)
    70.83(a)
      100329864  XM_002665427.2  XP_002665473.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG439216
    --
    6(a)
    1 → many
    X(12410667-12462394)


    ENSEMBL Gene Tree for SHF (if available)
    TreeFam Gene Tree for SHF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SHF gene
    SHE2  SHD2  SHB2  
    4 SIMAP similar genes for SHF using alignment to 15 protein entries:     SHF_HUMAN (see all proteins):
    SHB    PTPN11    SHE    SHD

    SHF for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SHF
    PGOHUM00000262061


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SHF (see all 703)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs17068151,2
    C,F,A,H--45458935(+) CCTCCG/CCGGGC 1 -- int11Minor allele frequency- C:0.50NA 2
    rs16483101,2
    C,F,A,H--45458954(-) CGCCCG/AGGCCT 1 -- int13Minor allele frequency- A:0.39NA 124
    rs71820811,2
    C--45459112(+) GCCAAG/AGAGAC 1 -- int13Minor allele frequency- A:0.27NA EA 242
    rs16483091,2
    C,F--45459182(-) CCTGCC/TACGCG 1 -- int14Minor allele frequency- T:0.38NA EA 126
    rs1825123451,2
    --45459262(+) GCTGTA/TGGCAG 1 -- int10--------
    rs71820071,2
    C--45459277(+) TTGGAA/CGCGCT 1 -- int10--------
    rs16299061,2
    C,F,A,H--45459564(-) CGGGCT/CAGAGG 1 -- ut31 ese320Minor allele frequency- C:0.49MN NS EA NA WA 2354
    rs1867001151,2
    --45459735(+) ACGGAA/GGCAGA 1 -- ut310--------
    rs1154257451,2
    C,F--45459760(+) CCCCAA/GGGGGC 1 -- ut311Minor allele frequency- G:0.02WA 118
    rs1908207861,2
    --45459788(+) CGCACC/GGACCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SHF (45459412 - 45493373 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SHF:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv904187CNV Loss21882294
    nsv518213CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SHF
    DNA2.0 Custom Variant and Variant Library Synthesis for SHF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 313350    OMIM disorders: --

    10 diseases for SHF:    About MalaCards
    otitis externa    diastolic heart failure    systolic heart failure    echinococcosis
    congestive heart failure    type 1 diabetes    neuroblastoma    cervicitis
    cerebritis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for SHF:
    Congestive heart failure

    SHF for disorders           About GeneDecksing

    Genetic Association Database (GAD): SHF

    Export disorders for SHF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SHF gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SHF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Shf, a Shb-like adapter protein, is involved in PDGF-alpha-receptor regulation of apoptosis. (PubMed id 11095946)1, 2, 3 Lindholm C.K.... Welsh M. (Biochem. Biophys. Res. Commun. 2000)
    2. Novel adaptor protein Shf interacts with ALK receptor and negatively regulates its downstream signals in neuroblastoma. (PubMed id 23360421)1 Takagi D....Nakagawara A. (Cancer Sci. 2013)
    3. Genome-wide association of serum uric acid concentration: replication of sequence variants in an island population of the Adriatic coast of Croatia. (PubMed id 22229870)4 Karns R....Deka R. (Ann. Hum. Genet. 2012)
    4. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614)4 Paterson A.D....Bull S.B. (Diabetes 2010)
    5. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 90525 HGNC: 25116 AceView: LOC90525 Ensembl:ENSG00000138606 euGenes: HUgn90525
    ECgene: SHF H-InvDB: SHF

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SHF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SHF gene:
    Search GeneIP for patents involving SHF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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