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Aliases for SHF Gene

Aliases for SHF Gene

  • Src Homology 2 Domain Containing F 2 3
  • CTD-2651B20.7 3

External Ids for SHF Gene

Previous GeneCards Identifiers for SHF Gene

  • GC15M043247
  • GC15M045459
  • GC15M022283

Summaries for SHF Gene

GeneCards Summary for SHF Gene

SHF (Src Homology 2 Domain Containing F) is a Protein Coding gene. Among its related pathways are PDGFR-alpha signaling pathway. An important paralog of this gene is SHB.

UniProtKB/Swiss-Prot for SHF Gene

  • Adapter protein which may play a role in the regulation of apoptosis in response to PDGF.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHF Gene

Genomics for SHF Gene

Regulatory Elements for SHF Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SHF Gene

45,167,214 bp from pter
45,201,329 bp from pter
34,116 bases
Minus strand

Genomic View for SHF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SHF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHF Gene

Proteins for SHF Gene

  • Protein details for SHF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH2 domain-containing adapter protein F
    Protein Accession:
    Secondary Accessions:
    • Q96IE8

    Protein attributes for SHF Gene

    423 amino acids
    Molecular mass:
    46768 Da
    Quaternary structure:
    • Interacts with phosphorylated Tyr-720 of PDGFRA via its SH2 domain.
    • The sequence described in PubMed:11095946 is over-extended by 57 aa at the N-terminus due to the presence of an uncorrected 5 mismatch compared to the reference genome sequence

    Alternative splice isoforms for SHF Gene


neXtProt entry for SHF Gene

Proteomics data for SHF Gene at MOPED

Post-translational modifications for SHF Gene

No data available for DME Specific Peptides for SHF Gene

Domains & Families for SHF Gene

Gene Families for SHF Gene

Protein Domains for SHF Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SH2 domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SHF: view

Function for SHF Gene

Molecular function for SHF Gene

UniProtKB/Swiss-Prot Function:
Adapter protein which may play a role in the regulation of apoptosis in response to PDGF.

Phenotypes for SHF Gene

GenomeRNAi human phenotypes for SHF:
genes like me logo Genes that share phenotypes with SHF: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SHF Gene

Localization for SHF Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SHF Gene

Pathways & Interactions for SHF Gene

SuperPathways for SHF Gene

genes like me logo Genes that share pathways with SHF: view

Pathways by source for SHF Gene

1 BioSystems pathway for SHF Gene

Interacting Proteins for SHF Gene

Gene Ontology (GO) - Biological Process for SHF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with SHF: view

No data available for SIGNOR curated interactions for SHF Gene

Drugs & Compounds for SHF Gene

No Compound Related Data Available

Transcripts for SHF Gene

Unigene Clusters for SHF Gene

Src homology 2 domain containing F:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SHF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g ^ 9 ^ 10a · 10b
SP1: - - - - - -
SP2: -
SP3: - - -
SP4: - - - - - - -
SP6: - - - - - -
SP7: - - -
SP8: - - - - -

Relevant External Links for SHF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SHF Gene

mRNA expression in normal human tissues for SHF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SHF Gene

This gene is overexpressed in Brain - Cerebellum (x10.4) and Brain - Cerebellar Hemisphere (x10.0).

Protein differential expression in normal tissues from HIPED for SHF Gene

This gene is overexpressed in Heart (46.1) and Fetal Brain (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SHF Gene

SOURCE GeneReport for Unigene cluster for SHF Gene Hs.310399

mRNA Expression by UniProt/SwissProt for SHF Gene

Tissue specificity: Expressed in skeletal muscle, brain, liver, prostate, testis, ovary, small intestine and colon.
genes like me logo Genes that share expression patterns with SHF: view

Protein tissue co-expression partners for SHF Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SHF Gene

This gene was present in the common ancestor of animals.

Orthologs for SHF Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SHF 35
  • 94.52 (n)
  • 97.55 (a)
SHF 36
  • 78 (a)
(Canis familiaris)
Mammalia SHF 35
  • 94.41 (n)
  • 97.52 (a)
SHF 36
  • 55 (a)
(Mus musculus)
Mammalia Shf 35
  • 92.72 (n)
  • 96.64 (a)
Shf 16
Shf 36
  • 96 (a)
(Pan troglodytes)
Mammalia SHF 35
  • 99.29 (n)
  • 99.29 (a)
SHF 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Shf 35
  • 93.12 (n)
  • 96.15 (a)
(Monodelphis domestica)
Mammalia SHF 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia SHF 36
  • 87 (a)
(Gallus gallus)
Aves SHF 35
  • 71.77 (n)
  • 72.81 (a)
SHF 36
  • 72 (a)
(Anolis carolinensis)
Reptilia SHF 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia shf 35
  • 70.23 (n)
  • 74.17 (a)
(Danio rerio)
Actinopterygii si:ch73-116f3.3 35
  • 66.04 (n)
  • 70.83 (a)
SHF 36
  • 76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43921 36
  • 6 (a)
Species with no ortholog for SHF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHF Gene

Gene Tree for SHF (if available)
Gene Tree for SHF (if available)

Paralogs for SHF Gene

Paralogs for SHF Gene Pseudogenes for SHF Gene

genes like me logo Genes that share paralogs with SHF: view

Variants for SHF Gene

Sequence variations from dbSNP and Humsavar for SHF Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1629906 -- 45,167,366(-) CGGGC(C/T)AGAGG utr-variant-3-prime
rs1648298 -- 45,197,863(+) GCGAG(A/G)GCATG intron-variant
rs1648299 -- 45,199,196(+) TCCAG(C/T)CTCTC intron-variant
rs1648300 -- 45,199,537(+) TCACT(C/T)CTACC intron-variant
rs1648301 -- 45,201,819(+) TGTTT(C/T)ATGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SHF Gene

Variant ID Type Subtype PubMed ID
nsv518213 CNV Gain 19592680
nsv904187 CNV Loss 21882294

Variation tolerance for SHF Gene

Residual Variation Intolerance Score: 69.91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.45; 71.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SHF Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHF Gene

Disorders for SHF Gene

Relevant External Links for SHF

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SHF: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHF Gene

Publications for SHF Gene

  1. Shf, a Shb-like adapter protein, is involved in PDGF-alpha-receptor regulation of apoptosis. (PMID: 11095946) Lindholm C.K. … Welsh M. (Biochem. Biophys. Res. Commun. 2000) 2 67
  2. Novel adaptor protein Shf interacts with ALK receptor and negatively regulates its downstream signals in neuroblastoma. (PMID: 23360421) Takagi D. … Nakagawara A. (Cancer Sci. 2013) 67
  3. Genome-wide association of serum uric acid concentration: replication of sequence variants in an island population of the Adriatic coast of Croatia. (PMID: 22229870) Karns R. … Deka R. (Ann. Hum. Genet. 2012) 67
  4. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PMID: 19875614) Paterson A.D. … Bull S.B. (Diabetes 2010) 67
  5. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 67

Products for SHF Gene

Sources for SHF Gene

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