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Aliases for SHF Gene

Aliases for SHF Gene

  • Src Homology 2 Domain Containing F 2 3 5
  • SH2 Domain-Containing Adapter Protein F 3
  • CTD-2651B20.7 3

External Ids for SHF Gene

Previous GeneCards Identifiers for SHF Gene

  • GC15M043247
  • GC15M045459
  • GC15M022283

Summaries for SHF Gene

GeneCards Summary for SHF Gene

SHF (Src Homology 2 Domain Containing F) is a Protein Coding gene. Among its related pathways are PDGFR-alpha signaling pathway. An important paralog of this gene is SHB.

UniProtKB/Swiss-Prot for SHF Gene

  • Adapter protein which may play a role in the regulation of apoptosis in response to PDGF.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHF Gene

Genomics for SHF Gene

Regulatory Elements for SHF Gene

Enhancers for SHF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F045165 0.5 ENCODE 13.5 +33.5 33478 4.7 PKNOX1 ARNT WRNIP1 SIN3A FEZF1 YBX1 YY1 ZNF207 ZNF143 SP3 DUOXA1 ENSG00000259539 SHF DUOX1 SLC28A2 CTDSPL2 DUOX2 ENSG00000259519
GH15F045161 0.7 Ensembl ENCODE 13.5 +38.4 38431 1.8 ARID4B RAD21 RFX5 SCRT2 ZNF143 FOS CREM DEK ZNF654 CBFB DUOXA1 ENSG00000259539 SHF DUOX1 SLC28A2 DUOX2 PIR61454 GC15P045136 GC15P045137 GC15P045138
GH15F045262 0.4 ENCODE 11.8 -62.2 -62160 1.2 GATA3 MTA2 IKZF1 TRIM22 BMI1 TBX21 TCF7L2 LOC101928414 SHF DUOX2 SLC28A2
GH15F045156 1 Ensembl ENCODE 11.6 +43.6 43576 2.0 KLF1 JUN KLF17 CEBPG KAT2B ZNF324 ZNF600 KLF8 CREM NFIA DUOXA1 ENSG00000259539 DUOX1 SHF SPATA5L1 SLC28A2 C15orf48 MIR147B PIR61454 GC15P045136
GH15F045306 0.8 Ensembl ENCODE 10.6 -106.0 -105953 1.0 GATAD2A CTCF ZNF654 NFIA TEAD1 TRIM22 RAD21 IKZF1 SMC3 TCF7 SHF SLC28A2 RNU7-5P SORD ENSG00000235390 LOC101928414
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SHF on UCSC Golden Path with GeneCards custom track

Promoters for SHF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SHF Gene

45,167,214 bp from pter
45,201,329 bp from pter
34,116 bases
Minus strand

Genomic View for SHF Gene

Genes around SHF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHF Gene

Proteins for SHF Gene

  • Protein details for SHF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH2 domain-containing adapter protein F
    Protein Accession:
    Secondary Accessions:
    • Q96IE8

    Protein attributes for SHF Gene

    423 amino acids
    Molecular mass:
    46768 Da
    Quaternary structure:
    • Interacts with phosphorylated Tyr-720 of PDGFRA via its SH2 domain.
    • The sequence described in PubMed:11095946 is over-extended by 57 aa at the N-terminus due to the presence of an uncorrected 5 mismatch compared to the reference genome sequence.

    Alternative splice isoforms for SHF Gene


neXtProt entry for SHF Gene

Post-translational modifications for SHF Gene

No data available for DME Specific Peptides for SHF Gene

Domains & Families for SHF Gene

Gene Families for SHF Gene

Protein Domains for SHF Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SH2 domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SHF: view

Function for SHF Gene

Molecular function for SHF Gene

UniProtKB/Swiss-Prot Function:
Adapter protein which may play a role in the regulation of apoptosis in response to PDGF.

Gene Ontology (GO) - Molecular Function for SHF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity IBA --
genes like me logo Genes that share ontologies with SHF: view

Phenotypes for SHF Gene

GenomeRNAi human phenotypes for SHF:
genes like me logo Genes that share phenotypes with SHF: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SHF Gene

Localization for SHF Gene

Subcellular locations from

Jensen Localization Image for SHF Gene COMPARTMENTS Subcellular localization image for SHF gene
Compartment Confidence
cytosol 3
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SHF Gene

Pathways & Interactions for SHF Gene

SuperPathways for SHF Gene

SuperPathway Contained pathways
1 PDGFR-alpha signaling pathway
genes like me logo Genes that share pathways with SHF: view

Pathways by source for SHF Gene

1 BioSystems pathway for SHF Gene

Interacting Proteins for SHF Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)
Selected Interacting proteins: ENSP00000290894 Q7M4L6-SHF_HUMAN for SHF Gene via STRING IID

Gene Ontology (GO) - Biological Process for SHF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IBA --
GO:0009967 positive regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with SHF: view

No data available for SIGNOR curated interactions for SHF Gene

Transcripts for SHF Gene

Unigene Clusters for SHF Gene

Src homology 2 domain containing F:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g ^ 9 ^ 10a · 10b
SP1: - - - - - -
SP2: -
SP3: - - -
SP4: - - - - - - -
SP6: - - - - - -
SP7: - - -
SP8: - - - - -

Relevant External Links for SHF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SHF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SHF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SHF Gene

This gene is overexpressed in Brain - Cerebellum (x10.4) and Brain - Cerebellar Hemisphere (x10.0).

Protein differential expression in normal tissues from HIPED for SHF Gene

This gene is overexpressed in Heart (46.1) and Fetal Brain (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SHF Gene

Protein tissue co-expression partners for SHF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SHF Gene:


SOURCE GeneReport for Unigene cluster for SHF Gene:


mRNA Expression by UniProt/SwissProt for SHF Gene:

Tissue specificity: Expressed in skeletal muscle, brain, liver, prostate, testis, ovary, small intestine and colon.
genes like me logo Genes that share expression patterns with SHF: view

Primer Products

Orthologs for SHF Gene

This gene was present in the common ancestor of animals.

Orthologs for SHF Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SHF 34 35
  • 99.29 (n)
(Bos Taurus)
Mammalia SHF 34 35
  • 94.52 (n)
(Canis familiaris)
Mammalia SHF 34 35
  • 94.41 (n)
(Rattus norvegicus)
Mammalia Shf 34
  • 93.12 (n)
(Mus musculus)
Mammalia Shf 34 16 35
  • 92.72 (n)
(Ornithorhynchus anatinus)
Mammalia SHF 35
  • 87 (a)
(Monodelphis domestica)
Mammalia SHF 35
  • 78 (a)
(Gallus gallus)
Aves SHF 34 35
  • 71.77 (n)
(Anolis carolinensis)
Reptilia SHF 35
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia shf 34
  • 70.23 (n)
(Danio rerio)
Actinopterygii SHF 35
  • 76 (a)
si:ch73-116f3.3 34
  • 66.04 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG43921 35
  • 6 (a)
Species where no ortholog for SHF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHF Gene

Gene Tree for SHF (if available)
Gene Tree for SHF (if available)

Paralogs for SHF Gene

Paralogs for SHF Gene

genes like me logo Genes that share paralogs with SHF: view

Variants for SHF Gene

Sequence variations from dbSNP and Humsavar for SHF Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10083684 -- 45,183,618(+) TCCAA(G/T)TCCTG intron-variant
rs11070443 -- 45,193,524(+) caata(A/G)ggcag intron-variant
rs111230516 -- 45,186,121(+) ACCTC(C/T)ATCAC intron-variant
rs111453330 -- 45,189,411(+) TTTTT(C/T)TGAGA intron-variant, upstream-variant-2KB
rs111595964 -- 45,186,367(+) GCCAA(A/C/T)GGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SHF Gene

Variant ID Type Subtype PubMed ID
dgv738e212 CNV loss 25503493
esv3581685 CNV loss 25503493
nsv1071210 CNV deletion 25765185
nsv518213 CNV gain 19592680
nsv569312 CNV loss 21841781
nsv569315 CNV gain 21841781

Variation tolerance for SHF Gene

Residual Variation Intolerance Score: 69.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.45; 71.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SHF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHF Gene

Disorders for SHF Gene

Relevant External Links for SHF

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SHF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHF Gene

Publications for SHF Gene

  1. Shf, a Shb-like adapter protein, is involved in PDGF-alpha-receptor regulation of apoptosis. (PMID: 11095946) Lindholm C.K. … Welsh M. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 64
  2. Novel adaptor protein Shf interacts with ALK receptor and negatively regulates its downstream signals in neuroblastoma. (PMID: 23360421) Takagi D. … Nakagawara A. (Cancer Sci. 2013) 3 64
  3. Genome-wide association of serum uric acid concentration: replication of sequence variants in an island population of the Adriatic coast of Croatia. (PMID: 22229870) Karns R. … Deka R. (Ann. Hum. Genet. 2012) 46 64
  4. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PMID: 19875614) Paterson A.D. … Bull S.B. (Diabetes 2010) 46 64
  5. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 4 64

Products for SHF Gene

Sources for SHF Gene

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