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Aliases for SHE Gene

Aliases for SHE Gene

  • Src Homology 2 Domain Containing E 2 3 5

External Ids for SHE Gene

Previous GeneCards Identifiers for SHE Gene

  • GC01M151266
  • GC01M152718
  • GC01M125815

Summaries for SHE Gene

GeneCards Summary for SHE Gene

SHE (Src Homology 2 Domain Containing E) is a Protein Coding gene. Diseases associated with SHE include Blepharoconjunctivitis and Blepharitis. An important paralog of this gene is SHF.

Additional gene information for SHE Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHE Gene

Genomics for SHE Gene

Regulatory Elements for SHE Gene

Enhancers for SHE Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H154384 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +115.9 115938 2 HDGF ATF1 FOXA2 ARID4B TCF12 GATA2 ELK1 ZNF143 ATF7 SP5 ATP8B2 IL6R-AS1 LOC101928101 RNU7-57P UBE2Q1-AS1 UBE2Q1 SHE TDRD10 C1orf189 SNAPIN
GH01H154479 1.4 Ensembl ENCODE dbSUPER 11.4 +22.1 22113 0 RB1 TBL1XR1 ARNT ARID4B ZNF2 RAD21 CHAMP1 RFX5 YY1 ZNF121 IL6R UBE2Q1-AS1 UBE2Q1 SHE TDRD10 IL6R-AS1 LOC101928101 CHRNB2 RNU7-57P ATP8B2
GH01H154404 1.4 ENCODE dbSUPER 10.3 +94.7 94732 5 HDGF FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ATP8B2 RNU7-57P UBE2Q1-AS1 UBE2Q1 SHE TDRD10 SNORA58B UBAP2L C1orf189 ADAR
GH01H154477 1.2 Ensembl ENCODE dbSUPER 11.4 +24.1 24088 1 SMARCA5 CTCF TRIM22 MAX ZEB2 REST RAD21 ZNF664 SMC3 ZSCAN29 UBE2Q1-AS1 UBE2Q1 SHE TDRD10 LOC101928101 IL6R-AS1 IL6R CHRNB2 RNU7-57P ATP8B2
GH01H154501 1.1 Ensembl ENCODE dbSUPER 12.2 -0.2 -214 2 MAZ SUZ12 CEBPB MAX USF2 CEBPG POLR2A MTA1 CEBPA EZH2 SHE UBE2Q1-AS1 UBE2Q1 TDRD10 IL6R PIR57366
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SHE on UCSC Golden Path with GeneCards custom track

Genomic Location for SHE Gene

Chromosome:
1
Start:
154,469,637 bp from pter
End:
154,502,113 bp from pter
Size:
32,477 bases
Orientation:
Minus strand

Genomic View for SHE Gene

Genes around SHE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHE Gene

Proteins for SHE Gene

  • Protein details for SHE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZ18-SHE_HUMAN
    Recommended name:
    SH2 domain-containing adapter protein E
    Protein Accession:
    Q5VZ18
    Secondary Accessions:
    • Q8TEQ5

    Protein attributes for SHE Gene

    Size:
    495 amino acids
    Molecular mass:
    53950 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SHE Gene

Post-translational modifications for SHE Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SHE Gene

No data available for DME Specific Peptides for SHE Gene

Domains & Families for SHE Gene

Gene Families for SHE Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for SHE Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SHE Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SHE: view

No data available for UniProtKB/Swiss-Prot for SHE Gene

Function for SHE Gene

Gene Ontology (GO) - Molecular Function for SHE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity IBA --
GO:0005515 protein binding IPI 24728074
genes like me logo Genes that share ontologies with SHE: view
genes like me logo Genes that share phenotypes with SHE: view

Animal Model Products

CRISPR Products

miRNA for SHE Gene

miRTarBase miRNAs that target SHE

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SHE
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SHE Gene

Localization for SHE Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SHE gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SHE Gene

Pathways & Interactions for SHE Gene

No Data Available

Gene Ontology (GO) - Biological Process for SHE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0009967 positive regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with SHE: view

No data available for Pathways by source and SIGNOR curated interactions for SHE Gene

Drugs & Compounds for SHE Gene

No Compound Related Data Available

Transcripts for SHE Gene

Unigene Clusters for SHE Gene

Src homology 2 domain containing E:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SHE
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SHE Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2:

Relevant External Links for SHE Gene

GeneLoc Exon Structure for
SHE
ECgene alternative splicing isoforms for
SHE

Expression for SHE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SHE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SHE Gene

This gene is overexpressed in Brain (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SHE Gene



Protein tissue co-expression partners for SHE Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SHE Gene:

SHE

SOURCE GeneReport for Unigene cluster for SHE Gene:

Hs.591481

Evidence on tissue expression from TISSUES for SHE Gene

  • Spleen(4.3)
  • Intestine(2.5)
genes like me logo Genes that share expression patterns with SHE: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SHE Gene

Orthologs for SHE Gene

This gene was present in the common ancestor of animals.

Orthologs for SHE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SHE 33 34
  • 95.96 (n)
cow
(Bos Taurus)
Mammalia SHE 33 34
  • 87.88 (n)
dog
(Canis familiaris)
Mammalia SHE 33 34
  • 85.42 (n)
mouse
(Mus musculus)
Mammalia She 33 16 34
  • 84.06 (n)
rat
(Rattus norvegicus)
Mammalia She 33
  • 83.44 (n)
oppossum
(Monodelphis domestica)
Mammalia SHE 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SHE 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves SHE 33 34
  • 69.8 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia she 33
  • 64.44 (n)
zebrafish
(Danio rerio)
Actinopterygii she 33 34
  • 58.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG43921 34
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3099 34
  • 21 (a)
OneToOne
Species where no ortholog for SHE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHE Gene

ENSEMBL:
Gene Tree for SHE (if available)
TreeFam:
Gene Tree for SHE (if available)

Paralogs for SHE Gene

Paralogs for SHE Gene

(3) SIMAP similar genes for SHE Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SHE: view

Variants for SHE Gene

Sequence variations from dbSNP and Humsavar for SHE Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000081201 -- 154,501,235(+) TCCCC(A/G)CCTCT intron-variant, upstream-variant-2KB
rs1000304809 -- 154,471,414(+) ACAAA(A/G)AAGAA intron-variant
rs1000485114 -- 154,499,520(+) TGGGT(C/T)AGAGG intron-variant
rs1000533260 -- 154,488,259(+) GTATA(-/ATTATT)ATTAT intron-variant
rs1000536320 -- 154,501,400(+) CCTTC(G/T)ACTGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SHE Gene

Variant ID Type Subtype PubMed ID
dgv584n54 CNV gain 21841781
dgv585n54 CNV gain 21841781
esv23279 CNV loss 19812545
nsv521887 CNV gain 19592680
nsv547942 CNV gain+loss 21841781
nsv547954 CNV loss 21841781

Variation tolerance for SHE Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SHE Gene

Human Gene Mutation Database (HGMD)
SHE
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SHE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHE Gene

Disorders for SHE Gene

MalaCards: The human disease database

(3) MalaCards diseases for SHE Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
blepharoconjunctivitis
blepharitis
strongyloidiasis
  • disseminated strongyloidiasis
- elite association - COSMIC cancer census association via MalaCards
Search SHE in MalaCards View complete list of genes associated with diseases

Relevant External Links for SHE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SHE
genes like me logo Genes that share disorders with SHE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SHE Gene

Publications for SHE Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PMID: 12693554) Jikuya H … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2003) 3 4 60
  4. Identification and characterization of two novel SH2 domain-containing proteins from a yeast two hybrid screen with the ABL tyrosine kinase. (PMID: 9315092) Oda T … Druker BJ (Oncogene 1997) 2 3 60
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 60

Products for SHE Gene

Sources for SHE Gene

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