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Aliases for SHE Gene

Aliases for SHE Gene

  • Src Homology 2 Domain Containing E 2 3 5

External Ids for SHE Gene

Previous GeneCards Identifiers for SHE Gene

  • GC01M151266
  • GC01M152718
  • GC01M125815

Summaries for SHE Gene

GeneCards Summary for SHE Gene

SHE (Src Homology 2 Domain Containing E) is a Protein Coding gene. Diseases associated with SHE include Blepharoconjunctivitis and Strongyloidiasis. An important paralog of this gene is SHF.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHE Gene

Genomics for SHE Gene

Regulatory Elements for SHE Gene

Enhancers for SHE Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SHE on UCSC Golden Path with GeneCards custom track

Promoters for SHE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SHE on UCSC Golden Path with GeneCards custom track

Genomic Location for SHE Gene

154,469,637 bp from pter
154,502,113 bp from pter
32,477 bases
Minus strand

Genomic View for SHE Gene

Genes around SHE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHE Gene

Proteins for SHE Gene

  • Protein details for SHE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH2 domain-containing adapter protein E
    Protein Accession:
    Secondary Accessions:
    • Q8TEQ5

    Protein attributes for SHE Gene

    495 amino acids
    Molecular mass:
    53950 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SHE Gene

Proteomics data for SHE Gene at MOPED

Post-translational modifications for SHE Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SHE Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHE Gene

Domains & Families for SHE Gene

Gene Families for SHE Gene

Protein Domains for SHE Gene


Suggested Antigen Peptide Sequences for SHE Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SH2 domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SHE: view

Function for SHE Gene

genes like me logo Genes that share phenotypes with SHE: view

Animal Model Products

miRNA for SHE Gene

miRTarBase miRNAs that target SHE

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SHE Gene

Localization for SHE Gene

Subcellular locations from

Jensen Localization Image for SHE Gene COMPARTMENTS Subcellular localization image for SHE gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SHE Gene

Pathways & Interactions for SHE Gene

SuperPathways for SHE Gene

No Data Available

Gene Ontology (GO) - Biological Process for SHE Gene


No data available for Pathways by source and SIGNOR curated interactions for SHE Gene

Drugs & Compounds for SHE Gene

No Compound Related Data Available

Transcripts for SHE Gene

Unigene Clusters for SHE Gene

Src homology 2 domain containing E:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SHE Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6

Relevant External Links for SHE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SHE Gene

mRNA expression in normal human tissues for SHE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SHE Gene

This gene is overexpressed in Brain (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SHE Gene

SOURCE GeneReport for Unigene cluster for SHE Gene Hs.591481

genes like me logo Genes that share expression patterns with SHE: view

Protein tissue co-expression partners for SHE Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SHE Gene

Orthologs for SHE Gene

This gene was present in the common ancestor of animals.

Orthologs for SHE Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SHE 35
  • 87.88 (n)
  • 91.11 (a)
SHE 36
  • 87 (a)
(Canis familiaris)
Mammalia SHE 35
  • 85.42 (n)
  • 85.27 (a)
SHE 36
  • 85 (a)
(Mus musculus)
Mammalia She 35
  • 84.06 (n)
  • 85.51 (a)
She 16
She 36
  • 84 (a)
(Pan troglodytes)
Mammalia SHE 35
  • 95.96 (n)
  • 95.48 (a)
SHE 36
  • 100 (a)
(Rattus norvegicus)
Mammalia She 35
  • 83.44 (n)
  • 84.68 (a)
(Monodelphis domestica)
Mammalia SHE 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia SHE 36
  • 71 (a)
(Gallus gallus)
Aves SHE 35
  • 69.8 (n)
  • 69.95 (a)
SHE 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia she 35
  • 64.44 (n)
  • 64.29 (a)
(Danio rerio)
Actinopterygii she 35
  • 58.91 (n)
  • 57.54 (a)
she 36
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43921 36
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3099 36
  • 21 (a)
Species with no ortholog for SHE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHE Gene

Gene Tree for SHE (if available)
Gene Tree for SHE (if available)

Paralogs for SHE Gene

Paralogs for SHE Gene

(3) SIMAP similar genes for SHE Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SHE: view

Variants for SHE Gene

Sequence variations from dbSNP and Humsavar for SHE Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs14021 -- 154,479,728(+) AGAAC(C/T)TGACA intron-variant, utr-variant-3-prime
rs3811447 -- 154,470,241(+) GGCAC(A/G)GGAGT utr-variant-3-prime
rs4359028 -- 154,480,052(+) CAGCG(A/G)TGGAG intron-variant, utr-variant-3-prime
rs4393148 -- 154,479,742(+) TGAGA(C/T)GCCTG intron-variant, utr-variant-3-prime
rs4269768 -- 154,495,495(+) CAGGC(A/T)TCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SHE Gene

Variant ID Type Subtype PubMed ID
nsv521887 CNV Gain 19592680
esv23279 CNV Loss 19812545

Variation tolerance for SHE Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SHE Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHE Gene

Disorders for SHE Gene

MalaCards: The human disease database

(3) MalaCards diseases for SHE Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • disseminated strongyloidiasis
- elite association - COSMIC cancer census association via MalaCards
Search SHE in MalaCards View complete list of genes associated with diseases

Relevant External Links for SHE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SHE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SHE Gene

Publications for SHE Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. Identification and characterization of two novel SH2 domain-containing proteins from a yeast two hybrid screen with the ABL tyrosine kinase. (PMID: 9315092) Oda T. … Druker B.J. (Oncogene 1997) 2 3
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome. (PMID: 24728074) Leung K.K. … Jones R.B. (Mol. Cell Proteomics 2014) 3
  5. Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation. (PMID: 25340798) Kauwe J.S. … Goate A.M. (PLoS Genet. 2014) 3

Products for SHE Gene

Sources for SHE Gene