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Aliases for SHE Gene

Aliases for SHE Gene

  • Src Homology 2 Domain Containing E 2 3 5

External Ids for SHE Gene

Previous GeneCards Identifiers for SHE Gene

  • GC01M151266
  • GC01M152718
  • GC01M125815

Summaries for SHE Gene

GeneCards Summary for SHE Gene

SHE (Src Homology 2 Domain Containing E) is a Protein Coding gene. Diseases associated with SHE include Blepharoconjunctivitis and Blepharitis. An important paralog of this gene is SHF.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHE Gene

Genomics for SHE Gene

Regulatory Elements for SHE Gene

Enhancers for SHE Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F154477 1.3 Ensembl ENCODE 21.3 +23.8 23802 2.2 CTCF MTA2 MAX TRIM22 REST RAD21 ZNF664 RAD51 SMC3 ZNF24 SHE UBE2Q1-AS1 UBE2Q1 TDRD10 LOC101928101 IL6R CHRNB2 RNU7-57P ATP8B2 ENSG00000201129
GH01F154489 1.2 FANTOM5 Ensembl ENCODE 14.2 +8.3 8313 8.0 ATF1 PKNOX1 YY1 GATA2 ZNF548 FOS JUNB ZNF488 REST TBX21 SLC27A3 TDRD10 CHTOP KRTCAP2 SHE THBS3 DCST1 UBE2Q1-AS1 UBE2Q1 ENSG00000272030
GH01F154479 0.7 Ensembl ENCODE 11.4 +22.1 22113 0.8 TBL1XR1 ARNT WRNIP1 SIN3A ARID4B ZNF2 RAD21 RFX5 CHAMP1 YY1 IL6R UBE2Q1-AS1 UBE2Q1 SHE TDRD10 LOC101928101 CHRNB2 RNU7-57P ATP8B2 ENSG00000201129
GH01F154478 0.2 ENCODE 11.4 +25.1 25074 0.1 SCRT2 UBE2Q1-AS1 UBE2Q1 SHE TDRD10 LOC101928101 IL6R CHRNB2 RNU7-57P ATP8B2 ENSG00000201129
GH01F154501 0.2 ENCODE 11.2 +0.1 77 1.5 SUZ12 NFIA KLF17 CEBPB CEBPG ZNF121 ZFHX2 POLR2A MTA1 CEBPA SHE TDRD10 IL6R ENSG00000273110
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SHE on UCSC Golden Path with GeneCards custom track

Promoters for SHE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SHE Gene

154,469,637 bp from pter
154,502,113 bp from pter
32,477 bases
Minus strand

Genomic View for SHE Gene

Genes around SHE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHE Gene

Proteins for SHE Gene

  • Protein details for SHE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH2 domain-containing adapter protein E
    Protein Accession:
    Secondary Accessions:
    • Q8TEQ5

    Protein attributes for SHE Gene

    495 amino acids
    Molecular mass:
    53950 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SHE Gene

Post-translational modifications for SHE Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SHE Gene

No data available for DME Specific Peptides for SHE Gene

Domains & Families for SHE Gene

Gene Families for SHE Gene

Protein Domains for SHE Gene


Suggested Antigen Peptide Sequences for SHE Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SH2 domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SHE: view

Function for SHE Gene

Gene Ontology (GO) - Molecular Function for SHE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity IBA --
GO:0005515 protein binding IPI 24728074
genes like me logo Genes that share ontologies with SHE: view
genes like me logo Genes that share phenotypes with SHE: view

Animal Model Products

miRNA for SHE Gene

miRTarBase miRNAs that target SHE

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SHE Gene

Localization for SHE Gene

Subcellular locations from

Jensen Localization Image for SHE Gene COMPARTMENTS Subcellular localization image for SHE gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SHE Gene

Pathways & Interactions for SHE Gene

SuperPathways for SHE Gene

No Data Available

Gene Ontology (GO) - Biological Process for SHE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0009967 positive regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with SHE: view

No data available for Pathways by source and SIGNOR curated interactions for SHE Gene

Transcripts for SHE Gene

Unigene Clusters for SHE Gene

Src homology 2 domain containing E:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHE Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6

Relevant External Links for SHE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SHE Gene

mRNA expression in normal human tissues for SHE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SHE Gene

This gene is overexpressed in Brain (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SHE Gene

Protein tissue co-expression partners for SHE Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SHE Gene:


SOURCE GeneReport for Unigene cluster for SHE Gene:

genes like me logo Genes that share expression patterns with SHE: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SHE Gene

Orthologs for SHE Gene

This gene was present in the common ancestor of animals.

Orthologs for SHE Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SHE 34 35
  • 95.96 (n)
(Bos Taurus)
Mammalia SHE 34 35
  • 87.88 (n)
(Canis familiaris)
Mammalia SHE 34 35
  • 85.42 (n)
(Mus musculus)
Mammalia She 34 16 35
  • 84.06 (n)
(Rattus norvegicus)
Mammalia She 34
  • 83.44 (n)
(Monodelphis domestica)
Mammalia SHE 35
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia SHE 35
  • 71 (a)
(Gallus gallus)
Aves SHE 34 35
  • 69.8 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia she 34
  • 64.44 (n)
(Danio rerio)
Actinopterygii she 34 35
  • 58.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG43921 35
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3099 35
  • 21 (a)
Species where no ortholog for SHE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHE Gene

Gene Tree for SHE (if available)
Gene Tree for SHE (if available)

Paralogs for SHE Gene

Paralogs for SHE Gene

(3) SIMAP similar genes for SHE Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SHE: view

Variants for SHE Gene

Sequence variations from dbSNP and Humsavar for SHE Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10047079 -- 154,495,659(+) GGCTG(C/T)GAGGT intron-variant, reference, missense
rs10558851 -- 154,498,200(+) CAATT(-/CTC)CTACC intron-variant
rs10594379 -- 154,478,447(+) AAAAA(-/AA)Cactc intron-variant
rs10633891 -- 154,471,706(+) TCTCT(-/CT)GTGTG intron-variant
rs10908840 -- 154,487,001(+) GGGCA(C/T)GGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SHE Gene

Variant ID Type Subtype PubMed ID
dgv584n54 CNV gain 21841781
dgv585n54 CNV gain 21841781
esv23279 CNV loss 19812545
nsv521887 CNV gain 19592680
nsv547942 CNV gain+loss 21841781
nsv547954 CNV loss 21841781

Variation tolerance for SHE Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SHE Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHE Gene

Disorders for SHE Gene

MalaCards: The human disease database

(3) MalaCards diseases for SHE Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • disseminated strongyloidiasis
- elite association - COSMIC cancer census association via MalaCards
Search SHE in MalaCards View complete list of genes associated with diseases

Relevant External Links for SHE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SHE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SHE Gene

Publications for SHE Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PMID: 12693554) Jikuya H. … Ohara O. (DNA Res. 2003) 3 4 64
  4. Identification and characterization of two novel SH2 domain-containing proteins from a yeast two hybrid screen with the ABL tyrosine kinase. (PMID: 9315092) Oda T. … Druker B.J. (Oncogene 1997) 2 3 64
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64

Products for SHE Gene

Sources for SHE Gene

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