SHE Gene
protein-coding GIFtS : 47
GCID: GC01 M154442
Src homology 2 domain containing E
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Aliasesfor SHE gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Src Homology 2 Domain Containing E 1 2 RP11-350G8.82 SH2 Domain-Containing Adapter Protein E2
Export aliases for SHE gene to outside databases Previous GC identifers: GC01M151266 GC01M152718 GC01M125815
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Summariesfor SHE gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Genomic Viewsfor SHE gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_004487.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SHE gene promoter: E2F-4 E2F-3a E2F-5 Elk-1 E2F-2 CREB AREB6 E2F-1 E2F deltaCREB Other transcription factors Search SABiosciences Chromatin IP Primers for SHE Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SHE
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21.3 SHE Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M154442: view genomic region
(about GC identifiers )
Start:
154,442,248 bp from pter
End:
154,474,589 bp from pter
Size:
32,342 bases
Orientation:
minus strand
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Proteinsfor SHE gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SHE_HUMAN, Q5VZ18 (See
protein sequence )Recommended Name: SH2 domain-containing adapter protein E Size : 495 amino acids; 53950 Da
Secondary accessions : Q8TEQ5Explore the universe of human proteins at neXtProt for SHE: NX_Q5VZ18 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q5VZ18 SHE Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_001010846.1 ENSEMBL proteins: ENSP00000452008 ENSP00000451961 ENSP00000307369 Human Recombinant Protein Products: SHE Antibody Products: Assay Products for SHE:
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Protein
Domains / Familiesfor SHE gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SHE for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q5VZ18 ProtoNet protein and cluster: Q5VZ18
1 Blocks protein family : IPB000980 SH2 domain signature UniProtKB/Swiss-Prot: SHE_HUMAN, Q5VZ18 Similarity : Contains 1 SH2 domain
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Functionfor SHE gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SHE (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SHEOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SHE (NM_001010846 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SHE Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SHE
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHE
1 GenomeRNAi human phenotype for SHE :
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Pathways & Interactionsfor SHE gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SHE STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)2 Interacting proteins for SHE (Q5VZ18 3 ENSP00000307369 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor SHE gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SHE Search CenterWatch for drugs/clinical trials and news about SHE
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Transcriptsfor SHE gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SHE gene: NM_001010846.2 Unigene Cluster for SHE:
Src homology 2 domain containing E Hs.591481 [show with all ESTs ] Unigene Representative Sequence: CR936736 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000486773 ENST00000555188 ENST00000304760 (uc001ffb.3 uc001ffc.3 )Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SHE (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SHEOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SHE (NM_001010846 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SHE Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SHE
Additional cDNA sequence: AK074067.1 AK126006.1 AK131004.1 BC117210.1 BC143765.1 CR936667.1 CR936736.1
5 DOTS entries : DT.40250579 DT.210343
DT.210462 DT.95246766 DT.210344 24/56 AceView cDNA sequences (see all 56 ):
BX093944 AI560856 BM974630 AI274859 AK126006 AA256192 AI143934 AA256153 BM991263 CB265391 AI218131 AW297942 CD300256 CA445011 CF552824 AK074067 AA774453 AW136012 AI797276 AA608795 CA436491 BE172699 AK131004 AA256824 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for SHE About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 SP1 :             SP2 :            
ECgene alternative splicing isoforms for SHE
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Expression for SHE gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SHE expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image SHE expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See SHE Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SHE SOURCE GeneReport for Unigene cluster: Hs.591481 SABiosciences Custom PCR Arrays for SHE Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SHEBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SHE QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SHE QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SHE In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHE
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Orthologsfor SHE gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for SHE gene from 3/13 species (see all 13 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
LOC1008577281
SH2 domain-containing adapter protein E-like
71.64(n) 72.64(a)
 
100857728 XM_003643441.1 XP_003643489.1
zebrafish (Danio rerio)
Actinopterygii
she1
Src homology 2 domain containing E
58.59(n) 59.18(a)
 
561493 XM_684895.4 XP_689987.3
fruit fly (Drosophila melanogaster)
Insecta
CG439216
--
5(a)
1 → many
X(12410667-12462394)
ENSEMBL Gene Tree for SHE (if available)TreeFam Gene Tree for SHE (if available)
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Paralogsfor SHE gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SHE gene SHF 2 ENSG00000255872 2 SHD 2 SHB 2 3 SIMAP similar genes for SHE using alignment to 4 protein entries: SHE_HUMAN (see all proteins ):SHF SHD SHB
SHE for paralogs About GeneDecksing
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Genomic Variantsfor SHE gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for SHE (154442248 - 154474589 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for SHE 1 Indel : 65008
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SHE
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Disorders
/ Diseasesfor SHE gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
SHE for disorders About GeneDecksing
OMIM gene information: 610482
OMIM disorders : --4 diseases for SHE : About MalaCards sulfhemoglobinemia strongyloidiasis blepharitis methemoglobinemia 1 disease from the University of Copenhagen DISEASES database for SHE :Strongyloidiasis Export disorders for SHE gene to outside databases
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Publicationsfor SHE gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SHE gene integrated from 9 sources : (articles sorted by number of sources associating them with SHE) Utopia : connect your pdf to the dynamic world of online information
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 1 , 2 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PubMed id 12693554) 1 , 2 Jikuya H....Ohara O. (2003) Identification and characterization of two novel SH2 domain-containing proteins from a yeast two hybrid screen with the ABL tyrosine kinase. (PubMed id 9315092) 1 , 3 Oda T....Druker B.J. (1997) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SHE gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SHE gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SHE gene
(According to HUGE )
About This Section --
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Specialized Databases showing SHE gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for SHE Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for SHE gene: Search GeneIP for patents involving SHE GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SHE gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies Browse OriGene shRNA RFPs OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SHE OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SHE OriGene Protein Over-expression Lysate for SHE Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SHE OriGene 3'-UTR Clone for SHE OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SHE OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SHE Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for SHE OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SHE OriGene Custom Protein Services for SHE OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SHE QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SHE QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SHE QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SHE QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SHE QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SHE
Search Tocris compounds for SHE
SHE Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHE
Search ThermoFisher Antibodies for SHE
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SHE
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Aliases for SHE
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