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SHE Gene

protein-coding   GIFtS: 48
GCID: GC01M154442

Src Homology 2 Domain Containing E

  See SHE-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Src Homology 2 Domain Containing E1 2
SH2 Domain-Containing Adapter Protein E2

External Ids:    HGNC: 270041   Entrez Gene: 1266692   Ensembl: ENSG000001692917   OMIM: 6104825   UniProtKB: Q5VZ183   

Export aliases for SHE gene to outside databases

Previous GC identifers: GC01M151266 GC01M152718 GC01M125815


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SHE Gene:
SHE (Src homology 2 domain containing E) is a protein-coding gene. Diseases associated with SHE include strongyloidiasis. An important paralog of this gene is SHF.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SHE gene promoter:
         E2F-4   E2F-3a   E2F-5   Elk-1   E2F-2   CREB   AREB6   E2F-1   E2F   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSHE promoter sequence
   Search Chromatin IP Primers for SHE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SHE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

SHE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHE gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M154442:  view genomic region     (about GC identifiers)

Start:
154,442,248 bp from pter      End:
154,474,589 bp from pter
Size:
32,342 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SHE_HUMAN, Q5VZ18 (See protein sequence)
Recommended Name: SH2 domain-containing adapter protein E  
Size: 495 amino acids; 53950 Da
Secondary accessions: Q8TEQ5

Explore the universe of human proteins at neXtProt for SHE: NX_Q5VZ18

Explore proteomics data for SHE at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SHE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001010846.1  
    ENSEMBL proteins: 
     ENSP00000452008   ENSP00000451961   ENSP00000307369  

    SHE Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for SHE
    Search eBioscience for ELISAs for SHE 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    1 InterPro protein domain:
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q5VZ18

    ProtoNet protein and cluster: Q5VZ18

    1 Blocks protein domain: IPB000980 SH2 domain signature

    UniProtKB/Swiss-Prot: SHE_HUMAN, Q5VZ18
    Similarity: Contains 1 SH2 domain


    Find genes that share domains with SHE           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SHE           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SHE:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SHE
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SHE
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SHE

    miRNA
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    miRTarBase miRNAs that target SHE:
    hsa-mir-124-3p (MIRT022447), hsa-mir-1 (MIRT023676)

    Block miRNA regulation of human, mouse, rat SHE using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SHE (see all 45):
    hsa-miR-513a-5p hsa-miR-1260b hsa-miR-128 hsa-miR-449a hsa-miR-342-3p hsa-miR-509-3-5p hsa-miR-181b hsa-miR-30c-2*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SHE

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    GenScript: all cDNA clones in your preferred vector: SHE (NM_001010846)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SHE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHE

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHE


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion2
    nucleus2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SHE
    Interactions:

        Search GeneGlobe Interaction Network for SHE

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for SHE (Q5VZ183 ENSP000003073694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005193, ENSP000003614234I2D: score=2 STRING: ENSP00000361423
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    FAXCENSP000003743284STRING: ENSP00000374328
    DAB2ENSP000003133914STRING: ENSP00000313391
    --ENSP000003602774STRING: ENSP00000360277
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SHE



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SHE gene: 
    NM_001010846.2  

    Unigene Cluster for SHE:

    Src homology 2 domain containing E
    Hs.591481  [show with all ESTs]
    Unigene Representative Sequence: CR936736
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486773 ENST00000555188 ENST00000304760(uc001ffb.3 uc001ffc.3)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SHE (see all 45):
    hsa-miR-513a-5p hsa-miR-1260b hsa-miR-128 hsa-miR-449a hsa-miR-342-3p hsa-miR-509-3-5p hsa-miR-181b hsa-miR-30c-2*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SHE
    Predesigned siRNA for gene silencing in human, mouse, rat SHE
    Clone
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    OriGene clones in human, mouse for SHE (see all 7)
    OriGene ORF clones in mouse, rat for SHE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SHE (NM_001010846)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SHE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHE
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SHE
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SHE
      QuantiTect SYBR Green Assays in human, mouse, rat SHE
      QuantiFast Probe-based Assays in human, mouse, rat SHE

    Additional mRNA sequence: 

    AK074067.1 AK126006.1 AK131004.1 BC117210.1 BC143765.1 CR936667.1 CR936736.1 

    5 DOTS entries:

    DT.40250579  DT.210343  DT.210462  DT.95246766  DT.210344 

    Selected AceView cDNA sequences (see all 56):

    BX093944 BM974630 AI560856 AI203653 CF552824 CA445011 AA410382 AW136012 
    AK074067 AW297942 AW014449 AI804489 BE172699 CD300256 AK131004 AI143934 
    AI274859 AW960603 AL705678 AA608795 AA256824 CA436491 BM991263 CB265391 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SHE    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
    SP1:                                    
    SP2:                                    


    ECgene alternative splicing isoforms for SHE

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SHE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SHE Expression
    About this image


    SHE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Endothelium (Cardiovascular System)
             Human umbilical vein endothelial cells (HUVEC)
    SHE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SHE Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591481
        Custom PCR Arrays for SHE
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SHE
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SHE
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    QuantiFast Probe-based Assays in human, mouse, rat SHE
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SHE gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia She1 , 5 src homology 2 domain-containing transforming protein more1, 5 84.06(n)1
    85.51(a)1
      3 (39.19 cM)5
    2145471  NM_172530.31  NP_766118.31 
     898313705 
    chicken
    (Gallus gallus)
    Aves SHE1 Src homology 2 domain containing E 69.8(n)
    69.95(a)
      100857728  XM_003643441.2  XP_003643489.2 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia she1 Src homology 2 domain containing E 64.44(n)
    64.29(a)
      100490744  XM_002943359.2  XP_002943405.1 
    zebrafish
    (Danio rerio)
    Actinopterygii she1 Src homology 2 domain containing E 58.91(n)
    57.54(a)
      561493  XM_684895.5  XP_689987.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG439216
    --
    7(a)
    1 → many
    X(12410667-12462394)


    ENSEMBL Gene Tree for SHE (if available)
    TreeFam Gene Tree for SHE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SHE gene
    SHF2  SHD2  SHB2  
    3 SIMAP similar genes for SHE using alignment to 4 protein entries:     SHE_HUMAN (see all proteins):
    SHF    SHD    SHB

    Find genes that share paralogs with SHE           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SHE (see all 411)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs760956931,2
    C,F--154451531(+) TCACCT/CGGTAC 1 -- int11Minor allele frequency- C:0.02NA 120
    rs1144000181,2
    C,F--154451533(+) ACCTGG/ATACAA 1 -- int11Minor allele frequency- A:0.01NA 120
    rs1996108831,2
    --154451538(+) TACAA-/TTTTTT 1 -- int10--------
    rs792954511,2
    C,F--154451548(+) TTTTTA/TAAATA 1 -- int11Minor allele frequency- T:0.12WA 118
    rs1922175181,2
    --154451601(+) GCATGA/GGACAT 1 -- int10--------
    rs1417476661,2
    --154451613(+) TGTATG/TAATAA 1 -- int10--------
    rs1167612731,2
    C,F--154451723(+) TGGCAG/ATAAAA 1 -- int11Minor allele frequency- A:0.12WA 118
    rs1501626931,2
    C--154451744(+) TTACTA/GTTTTA 1 -- int10--------
    rs1386702611,2
    --154451795(+) CAGAGC/TAAATA 1 -- int10--------
    rs1834916811,2
    --154452049(+) CAACCA/TGAAGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SHE (154442248 - 154474589 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SHE:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv23279CNV Loss19812545
    nsv521887CNV Gain19592680

    Human Gene Mutation Database (HGMD): SHE
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SHE
    DNA2.0 Custom Variant and Variant Library Synthesis for SHE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610482    OMIM disorders: --

    1 disease for SHE:    
    About MalaCards
    strongyloidiasis

    1 disease from the University of Copenhagen DISEASES database for SHE:
    Strongyloidiasis

    Find genes that share disorders with SHE           About GenesLikeMe


    Export disorders for SHE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SHE gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SHE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PubMed id 12693554)1, 2 Jikuya H....Ohara O. (DNA Res. 2003)
    4. Identification and characterization of two novel SH2 domain-containing proteins from a yeast two hybrid screen with the ABL tyrosine kinase. (PubMed id 9315092)1, 3 Oda T....Druker B.J. (Oncogene 1997)
    5. A whole genome screen for HIV restriction factors. (PubMed id 22082156)1 Liu L....McKnight A. (Retrovirology 2011)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 126669 HGNC: 27004 AceView: LOC126669 Ensembl:ENSG00000169291 euGenes: HUgn126669
    ECgene: SHE H-InvDB: SHE

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SHE Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SHE gene:
    Search GeneIP for patents involving SHE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     QuantiFast Probe-based Assays in human, mouse, rat SHE QuantiTect SYBR Green Assays in human, mouse, rat SHE
     Custom PCR Arrays for SHE Search Chromatin IP Primers for SHE
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     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
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     Search for Antibodies & Assays

     Search Tocris compounds for SHE
     Browse Sino Biological Proteins
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SHE
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     Search Addgene for plasmids for SHE
      Search eBioscience for proteins for SHE
      Search eBioscience for elisas for SHE
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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