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Aliases for SHE Gene

Aliases for SHE Gene

  • Src Homology 2 Domain Containing E 2 3

External Ids for SHE Gene

Summaries for SHE Gene

GeneCards Summary for SHE Gene

SHE (Src Homology 2 Domain Containing E) is a Protein Coding gene. Diseases associated with SHE include strongyloidiasis. An important paralog of this gene is SHF.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHE Gene

Genomics for SHE Gene

Genomic Location for SHE Gene

Start:
154,469,637 bp from pter
End:
154,502,113 bp from pter
Size:
32,477 bases
Orientation:
Minus strand

Genomic View for SHE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SHE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHE Gene

Regulatory Elements for SHE Gene

Proteins for SHE Gene

  • Protein details for SHE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZ18-SHE_HUMAN
    Recommended name:
    SH2 domain-containing adapter protein E
    Protein Accession:
    Q5VZ18
    Secondary Accessions:
    • Q8TEQ5

    Protein attributes for SHE Gene

    Size:
    495 amino acids
    Molecular mass:
    53950 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SHE Gene

Proteomics data for SHE Gene at MOPED

Post-translational modifications for SHE Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SHE Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHE Gene

Domains for SHE Gene

Gene Families for SHE Gene

HGNC:
  • SH2D :SH2 domain containing

Protein Domains for SHE Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SHE Gene

Graphical View of Domain Structure for InterPro Entry

Q5VZ18

UniProtKB/Swiss-Prot:

SHE_HUMAN
Domain:
  • Contains 1 SH2 domain.:
    • Q5VZ18
genes like me logo Genes that share domains with SHE: view

Function for SHE Gene

Gene Ontology (GO) - Molecular Function for SHE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24728074
genes like me logo Genes that share ontologies with SHE: view

Phenotypes for SHE Gene

GenomeRNAi human phenotypes for SHE:
genes like me logo Genes that share phenotypes with SHE: view

miRNA for SHE Gene

miRTarBase miRNAs that target SHE

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SHE Gene

Localization for SHE Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SHE Gene COMPARTMENTS Subcellular localization image for SHE gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SHE Gene

Pathways for SHE Gene

SuperPathways for SHE Gene

No Data Available

Gene Ontology (GO) - Biological Process for SHE Gene

None

No data available for Pathways by source for SHE Gene

Transcripts for SHE Gene

Unigene Clusters for SHE Gene

Src homology 2 domain containing E:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SHE Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2:

Relevant External Links for SHE Gene

GeneLoc Exon Structure for
SHE
ECgene alternative splicing isoforms for
SHE

Expression for SHE Gene

mRNA expression in normal human tissues for SHE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SHE Gene

SOURCE GeneReport for Unigene cluster for SHE Gene Hs.591481

genes like me logo Genes that share expressions with SHE: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SHE Gene

Orthologs for SHE Gene

This gene was present in the common ancestor of animals.

Orthologs for SHE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SHE 35
  • 95.96 (n)
  • 95.48 (a)
SHE 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SHE 35
  • 87.88 (n)
  • 91.11 (a)
SHE 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SHE 35
  • 85.42 (n)
  • 85.27 (a)
SHE 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia She 35
  • 84.06 (n)
  • 85.51 (a)
She 16
She 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SHE 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SHE 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia She 35
  • 83.44 (n)
  • 84.68 (a)
chicken
(Gallus gallus)
Aves SHE 35
  • 69.8 (n)
  • 69.95 (a)
SHE 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia she 35
  • 64.44 (n)
  • 64.29 (a)
zebrafish
(Danio rerio)
Actinopterygii she 35
  • 58.91 (n)
  • 57.54 (a)
she 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG43921 36
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3099 36
  • 21 (a)
OneToOne
Species with no ortholog for SHE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHE Gene

ENSEMBL:
Gene Tree for SHE (if available)
TreeFam:
Gene Tree for SHE (if available)

Paralogs for SHE Gene

Paralogs for SHE Gene

Selected SIMAP similar genes for SHE Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SHE: view

Variants for SHE Gene

Sequence variations from dbSNP and Humsavar for SHE Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs14021 -- 154,479,728(+) AGAAC(C/T)TGACA utr-variant-3-prime, intron-variant, nc-transcript-variant
rs3811447 -- 154,470,241(+) GGCAC(A/G)GGAGT utr-variant-3-prime
rs4269768 -- 154,495,495(+) CAGGC(A/T)TCCTG intron-variant
rs4359028 -- 154,480,052(+) CAGCG(A/G)TGGAG utr-variant-3-prime, intron-variant, nc-transcript-variant
rs4393148 -- 154,479,742(+) TGAGA(C/T)GCCTG utr-variant-3-prime, intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for SHE Gene

Variant ID Type Subtype PubMed ID
nsv521887 CNV Gain 19592680
esv23279 CNV Loss 19812545

Relevant External Links for SHE Gene

HapMap Linkage Disequilibrium report
SHE
Human Gene Mutation Database (HGMD)
SHE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHE Gene

Disorders for SHE Gene

(1) MalaCards Diseases for SHE Gene

Search for SHE Gene in MalaCards »

(1) University of Copenhagen DISEASES for SHE Gene

genes like me logo Genes that share disorders with SHE: view

No data available for UniProtKB/Swiss-Prot for SHE Gene

Publications for SHE Gene

  1. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PMID: 12693554) Jikuya H. … Ohara O. (DNA Res. 2003) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Identification and characterization of two novel SH2 domain-containing proteins from a yeast two hybrid screen with the ABL tyrosine kinase. (PMID: 9315092) Oda T. … Druker B.J. (Oncogene 1997) 2 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SHE Gene

Sources for SHE Gene

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