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Aliases for SHD Gene

Aliases for SHD Gene

  • Src Homology 2 Domain Containing Transforming Protein D 2 3

External Ids for SHD Gene

Previous GeneCards Identifiers for SHD Gene

  • GC19P004218
  • GC19P004229
  • GC19P004230
  • GC19P004041

Summaries for SHD Gene

GeneCards Summary for SHD Gene

SHD (Src Homology 2 Domain Containing Transforming Protein D) is a Protein Coding gene. Diseases associated with SHD include tay-sachs disease. An important paralog of this gene is SHF.

UniProtKB/Swiss-Prot for SHD Gene

  • May function as an adapter protein.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHD Gene

Genomics for SHD Gene

Regulatory Elements for SHD Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SHD Gene

4,278,601 bp from pter
4,290,724 bp from pter
12,124 bases
Plus strand

Genomic View for SHD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SHD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHD Gene

Proteins for SHD Gene

  • Protein details for SHD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH2 domain-containing adapter protein D
    Protein Accession:
    Secondary Accessions:
    • Q96NC2

    Protein attributes for SHD Gene

    340 amino acids
    Molecular mass:
    38264 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SHD Gene

Proteomics data for SHD Gene at MOPED

Post-translational modifications for SHD Gene

Other Protein References for SHD Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SHD Gene

Domains for SHD Gene

Gene Families for SHD Gene

  • SH2D :SH2 domain containing

Protein Domains for SHD Gene


Suggested Antigen Peptide Sequences for SHD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96IW2
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SHD: view

Function for SHD Gene

Molecular function for SHD Gene

UniProtKB/Swiss-Prot Function:
May function as an adapter protein.

Gene Ontology (GO) - Molecular Function for SHD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24728074
genes like me logo Genes that share ontologies with SHD: view

Phenotypes for SHD Gene

GenomeRNAi human phenotypes for SHD:
genes like me logo Genes that share phenotypes with SHD: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SHD

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SHD Gene

Localization for SHD Gene

Subcellular locations from

Jensen Localization Image for SHD Gene COMPARTMENTS Subcellular localization image for SHD gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SHD Gene

Pathways for SHD Gene

SuperPathways for SHD Gene

No Data Available

Gene Ontology (GO) - Biological Process for SHD Gene


No data available for Pathways by source for SHD Gene

Transcripts for SHD Gene

Unigene Clusters for SHD Gene

Src homology 2 domain containing transforming protein D:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SHD

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHD Gene

No ASD Table

Relevant External Links for SHD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SHD Gene

mRNA expression in normal human tissues for SHD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SHD Gene

This gene is overexpressed in Heart - Atrial Appendage (11.7), Brain - Cortex (6.1), and Brain - Frontal Cortex (BA9) (5.6).

SOURCE GeneReport for Unigene cluster for SHD Gene Hs.7423

genes like me logo Genes that share expressions with SHD: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for SHD Gene

Orthologs for SHD Gene

This gene was present in the common ancestor of animals.

Orthologs for SHD Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SHD 35
  • 87.16 (n)
  • 90 (a)
SHD 36
  • 86 (a)
(Canis familiaris)
Mammalia SHD 35
  • 86.67 (n)
  • 89.41 (a)
SHD 36
  • 74 (a)
(Mus musculus)
Mammalia Shd 35
  • 80.54 (n)
  • 81.06 (a)
Shd 16
Shd 36
  • 76 (a)
(Pan troglodytes)
Mammalia SHD 35
  • 99.41 (n)
  • 99.41 (a)
SHD 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Shd 35
  • 79.19 (n)
  • 77.95 (a)
(Monodelphis domestica)
Mammalia SHD 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia SHD 36
  • 41 (a)
(Anolis carolinensis)
Reptilia SHD 36
  • 59 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13544 35
(Danio rerio)
Actinopterygii shdb 35
  • 63.37 (n)
  • 62.28 (a)
wufb38a12 35
shda 36
  • 44 (a)
shdb 36
  • 50 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8701 35
fruit fly
(Drosophila melanogaster)
Insecta CG43921 36
  • 6 (a)
Species with no ortholog for SHD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHD Gene

Gene Tree for SHD (if available)
Gene Tree for SHD (if available)

Paralogs for SHD Gene

Paralogs for SHD Gene

Selected SIMAP similar genes for SHD Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SHD: view

Variants for SHD Gene

Sequence variations from dbSNP and Humsavar for SHD Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs888928 -- 4,288,208(+) GGGAA(C/T)GGCCC intron-variant
rs888929 -- 4,288,223(+) TGAGA(C/T)ATCTG intron-variant
rs888930 - 4,288,335(+) GACCA(A/G)CCCCC reference, missense
rs888931 -- 4,288,558(+) AGCTC(A/C)CCATC intron-variant
rs1990931 -- 4,282,491(-) GCCTC(A/G)GGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SHD Gene

Variant ID Type Subtype PubMed ID
nsv910817 CNV Loss 21882294
nsv910818 CNV Loss 21882294
nsv833717 CNV Loss 17160897
nsv833718 CNV Loss 17160897
nsv910820 CNV Gain 21882294
dgv3674n71 CNV Loss 21882294

Relevant External Links for SHD Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHD Gene

Disorders for SHD Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SHD Gene in MalaCards »

(1) Diseases for SHD Gene including...

(2) University of Copenhagen DISEASES for SHD Gene

genes like me logo Genes that share disorders with SHD: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for SHD Gene

Publications for SHD Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Identification and characterization of two novel SH2 domain-containing proteins from a yeast two hybrid screen with the ABL tyrosine kinase. (PMID: 9315092) Oda T. … Druker B.J. (Oncogene 1997) 2 3
  4. Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation. (PMID: 10454579) Kim H.J. … Lee J.W. (Mol. Cell. Biol. 1999) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SHD Gene

Sources for SHD Gene

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