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Aliases for SHD Gene

Aliases for SHD Gene

  • Src Homology 2 Domain Containing Transforming Protein D 2 3 5

External Ids for SHD Gene

Previous GeneCards Identifiers for SHD Gene

  • GC19P004218
  • GC19P004229
  • GC19P004230
  • GC19P004041

Summaries for SHD Gene

GeneCards Summary for SHD Gene

SHD (Src Homology 2 Domain Containing Transforming Protein D) is a Protein Coding gene. An important paralog of this gene is SHB.

UniProtKB/Swiss-Prot for SHD Gene

  • May function as an adapter protein.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHD Gene

Genomics for SHD Gene

Regulatory Elements for SHD Gene

Enhancers for SHD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SHD on UCSC Golden Path with GeneCards custom track

Promoters for SHD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SHD Gene

4,278,601 bp from pter
4,290,724 bp from pter
12,124 bases
Plus strand

Genomic View for SHD Gene

Genes around SHD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHD Gene

Proteins for SHD Gene

  • Protein details for SHD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH2 domain-containing adapter protein D
    Protein Accession:
    Secondary Accessions:
    • Q96NC2

    Protein attributes for SHD Gene

    340 amino acids
    Molecular mass:
    38264 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SHD Gene

Post-translational modifications for SHD Gene

Other Protein References for SHD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHD Gene

Domains & Families for SHD Gene

Gene Families for SHD Gene

Protein Domains for SHD Gene


Suggested Antigen Peptide Sequences for SHD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SH2 domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SHD: view

Function for SHD Gene

Molecular function for SHD Gene

UniProtKB/Swiss-Prot Function:
May function as an adapter protein.

Gene Ontology (GO) - Molecular Function for SHD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24728074
genes like me logo Genes that share ontologies with SHD: view
genes like me logo Genes that share phenotypes with SHD: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SHD Gene

Localization for SHD Gene

Subcellular locations from

Jensen Localization Image for SHD Gene COMPARTMENTS Subcellular localization image for SHD gene
Compartment Confidence
cytosol 4
cytoskeleton 2
nucleus 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SHD Gene

Pathways & Interactions for SHD Gene

SuperPathways for SHD Gene

No Data Available

Gene Ontology (GO) - Biological Process for SHD Gene


No data available for Pathways by source and SIGNOR curated interactions for SHD Gene

Drugs & Compounds for SHD Gene

No Compound Related Data Available

Transcripts for SHD Gene

Unigene Clusters for SHD Gene

Src homology 2 domain containing transforming protein D:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHD Gene

No ASD Table

Relevant External Links for SHD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SHD Gene

mRNA expression in normal human tissues for SHD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SHD Gene

This gene is overexpressed in Heart - Atrial Appendage (x11.7), Brain - Cortex (x6.1), and Brain - Frontal Cortex (BA9) (x5.6).

NURSA nuclear receptor signaling pathways regulating expression of SHD Gene:


SOURCE GeneReport for Unigene cluster for SHD Gene:

genes like me logo Genes that share expression patterns with SHD: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SHD Gene

Orthologs for SHD Gene

This gene was present in the common ancestor of animals.

Orthologs for SHD Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SHD 34
  • 87.16 (n)
  • 90 (a)
SHD 35
  • 86 (a)
(Canis familiaris)
Mammalia SHD 34
  • 86.67 (n)
  • 89.41 (a)
SHD 35
  • 74 (a)
(Mus musculus)
Mammalia Shd 34
  • 80.54 (n)
  • 81.06 (a)
Shd 16
Shd 35
  • 76 (a)
(Pan troglodytes)
Mammalia SHD 34
  • 99.41 (n)
  • 99.41 (a)
SHD 35
  • 99 (a)
(Rattus norvegicus)
Mammalia Shd 34
  • 79.19 (n)
  • 77.95 (a)
(Monodelphis domestica)
Mammalia SHD 35
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia SHD 35
  • 41 (a)
(Anolis carolinensis)
Reptilia SHD 35
  • 59 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13544 34
(Danio rerio)
Actinopterygii shdb 34
  • 63.37 (n)
  • 62.28 (a)
wufb38a12 34
shda 35
  • 44 (a)
shdb 35
  • 50 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8701 34
fruit fly
(Drosophila melanogaster)
Insecta CG43921 35
  • 6 (a)
Species where no ortholog for SHD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHD Gene

Gene Tree for SHD (if available)
Gene Tree for SHD (if available)

Paralogs for SHD Gene

Paralogs for SHD Gene

(2) SIMAP similar genes for SHD Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SHD: view

Variants for SHD Gene

Sequence variations from dbSNP and Humsavar for SHD Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2287714 - 4,283,062(-) TCTGC(C/T)GGGAA reference, missense
rs888930 - 4,288,335(+) GACCA(A/G)CCCCC reference, missense
rs10424958 -- 4,287,090(+) gcact(C/T)tggga intron-variant
rs10425598 -- 4,279,458(+) CGGGA(C/T)TGGGG utr-variant-5-prime
rs10426910 -- 4,281,253(+) CAGCC(C/T)GGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SHD Gene

Variant ID Type Subtype PubMed ID
esv3643494 CNV loss 21293372
nsv578442 CNV loss 21841781
nsv833717 CNV loss 17160897
nsv833718 CNV loss 17160897

Variation tolerance for SHD Gene

Residual Variation Intolerance Score: 56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.03; 96.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SHD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHD Gene

Disorders for SHD Gene

Relevant External Links for SHD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SHD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHD Gene

Publications for SHD Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Identification and characterization of two novel SH2 domain-containing proteins from a yeast two hybrid screen with the ABL tyrosine kinase. (PMID: 9315092) Oda T. … Druker B.J. (Oncogene 1997) 2 3 65
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 65
  5. Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome. (PMID: 24728074) Leung K.K. … Jones R.B. (Mol. Cell Proteomics 2014) 3 65

Products for SHD Gene

Sources for SHD Gene

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