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Aliases for SHD Gene

Aliases for SHD Gene

  • Src Homology 2 Domain Containing Transforming Protein D 2 3 5

External Ids for SHD Gene

Previous GeneCards Identifiers for SHD Gene

  • GC19P004218
  • GC19P004229
  • GC19P004230
  • GC19P004041

Summaries for SHD Gene

GeneCards Summary for SHD Gene

SHD (Src Homology 2 Domain Containing Transforming Protein D) is a Protein Coding gene. An important paralog of this gene is SHB.

UniProtKB/Swiss-Prot for SHD Gene

  • May function as an adapter protein.

Additional gene information for SHD Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHD Gene

Genomics for SHD Gene

GeneHancer (GH) Regulatory Elements for SHD Gene

Promoters and enhancers for SHD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I004277 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 -0.3 -253 2.7 HDAC1 HDGF KLF17 EGR1 SCRT2 RCOR1 KLF7 SMARCA5 ZNF398 ZNF148 SHD CCDC94 GC19M004242
GH19I004340 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.2 +63.8 63842 3.5 HDGF FOXA2 PKNOX1 CLOCK MLX ARID4B NEUROD1 SIN3A DMAP1 YY1 STAP2 MPND SH3GL1 ENSG00000267255 TMIGD2 FSD1 SHD CHAF1A CCDC94 ENSG00000269425
GH19I004347 Enhancer 0.3 ENCODE 12.2 +68.9 68879 0.8 ZNF10 EIF1P6 STAP2 TMIGD2 FSD1 SHD SH3GL1 CHAF1A MPND ENSG00000269807
GH19I004344 Enhancer 0.3 ENCODE 12.2 +65.8 65785 0.1 BCOR MPND STAP2 FSD1 TMIGD2 SHD SH3GL1 CHAF1A EIF1P6
GH19I004284 Enhancer 1 Ensembl ENCODE 0.4 +6.2 6171 0.9 HDAC1 PKNOX1 ARID4B SCRT2 FOS ATF7 SP3 PHF21A RXRA NFYC SHD TMIGD2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SHD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SHD gene promoter:

Genomic Locations for SHD Gene

Genomic Locations for SHD Gene
chr19:4,278,601-4,290,724
(GRCh38/hg38)
Size:
12,124 bases
Orientation:
Plus strand
chr19:4,278,598-4,290,721
(GRCh37/hg19)

Genomic View for SHD Gene

Genes around SHD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHD Gene

Proteins for SHD Gene

  • Protein details for SHD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IW2-SHD_HUMAN
    Recommended name:
    SH2 domain-containing adapter protein D
    Protein Accession:
    Q96IW2
    Secondary Accessions:
    • Q96NC2

    Protein attributes for SHD Gene

    Size:
    340 amino acids
    Molecular mass:
    38264 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SHD Gene

Post-translational modifications for SHD Gene

Other Protein References for SHD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHD Gene

Domains & Families for SHD Gene

Gene Families for SHD Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SHD Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SHD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SHD: view

No data available for UniProtKB/Swiss-Prot for SHD Gene

Function for SHD Gene

Molecular function for SHD Gene

UniProtKB/Swiss-Prot Function:
May function as an adapter protein.

Gene Ontology (GO) - Molecular Function for SHD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity IBA --
GO:0005515 protein binding IPI 24728074
genes like me logo Genes that share ontologies with SHD: view
genes like me logo Genes that share phenotypes with SHD: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SHD

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SHD Gene

Localization for SHD Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SHD gene
Compartment Confidence
cytosol 4
cytoskeleton 2
nucleus 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Microtubule organizing center (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SHD Gene

Pathways & Interactions for SHD Gene

No Data Available

Gene Ontology (GO) - Biological Process for SHD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0009967 positive regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with SHD: view

No data available for Pathways by source and SIGNOR curated interactions for SHD Gene

Drugs & Compounds for SHD Gene

No Compound Related Data Available

Transcripts for SHD Gene

Unigene Clusters for SHD Gene

Src homology 2 domain containing transforming protein D:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SHD

Alternative Splicing Database (ASD) splice patterns (SP) for SHD Gene

No ASD Table

Relevant External Links for SHD Gene

GeneLoc Exon Structure for
SHD
ECgene alternative splicing isoforms for
SHD

Expression for SHD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SHD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SHD Gene

This gene is overexpressed in Heart - Atrial Appendage (x11.7), Brain - Cortex (x6.1), and Brain - Frontal Cortex (BA9) (x5.6).

NURSA nuclear receptor signaling pathways regulating expression of SHD Gene:

SHD

SOURCE GeneReport for Unigene cluster for SHD Gene:

Hs.7423

Evidence on tissue expression from TISSUES for SHD Gene

  • Nervous system(3.5)
genes like me logo Genes that share expression patterns with SHD: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SHD Gene

Orthologs for SHD Gene

This gene was present in the common ancestor of animals.

Orthologs for SHD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SHD 33 34
  • 99.41 (n)
cow
(Bos Taurus)
Mammalia SHD 33 34
  • 87.16 (n)
dog
(Canis familiaris)
Mammalia SHD 33 34
  • 86.67 (n)
mouse
(Mus musculus)
Mammalia Shd 33 16 34
  • 80.54 (n)
rat
(Rattus norvegicus)
Mammalia Shd 33
  • 79.19 (n)
oppossum
(Monodelphis domestica)
Mammalia SHD 34
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SHD 34
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SHD 34
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13544 33
zebrafish
(Danio rerio)
Actinopterygii shdb 33 34
  • 63.37 (n)
shda 34
  • 44 (a)
OneToMany
wufb38a12 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8701 33
fruit fly
(Drosophila melanogaster)
Insecta CG43921 34
  • 6 (a)
OneToMany
Species where no ortholog for SHD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHD Gene

ENSEMBL:
Gene Tree for SHD (if available)
TreeFam:
Gene Tree for SHD (if available)

Paralogs for SHD Gene

Paralogs for SHD Gene

(2) SIMAP similar genes for SHD Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SHD: view

Variants for SHD Gene

Sequence variations from dbSNP and Humsavar for SHD Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000116650 -- 4,278,176(+) A/G upstream_transcript_variant
rs1000326532 -- 4,290,945(+) G/A downstream_transcript_variant
rs1000791310 -- 4,289,267(+) C/T intron_variant
rs1000823890 -- 4,289,955(+) A/G intron_variant
rs1001028938 -- 4,283,581(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SHD Gene

Variant ID Type Subtype PubMed ID
esv3643494 CNV loss 21293372
nsv578442 CNV loss 21841781
nsv833717 CNV loss 17160897
nsv833718 CNV loss 17160897

Variation tolerance for SHD Gene

Residual Variation Intolerance Score: 56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.03; 96.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SHD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SHD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHD Gene

Disorders for SHD Gene

No disorders were found for SHD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHD Gene

Publications for SHD Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Identification and characterization of two novel SH2 domain-containing proteins from a yeast two hybrid screen with the ABL tyrosine kinase. (PMID: 9315092) Oda T … Druker BJ (Oncogene 1997) 2 3 58
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58
  5. Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome. (PMID: 24728074) Leung KK … Jones RB (Molecular & cellular proteomics : MCP 2014) 3 58

Products for SHD Gene

  • Addgene plasmids for SHD

Sources for SHD Gene

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