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Aliases for SHCBP1L Gene

Aliases for SHCBP1L Gene

  • SHC SH2-Domain Binding Protein 1-Like 2 3
  • C1orf14 3 4
  • SHC SH2 Domain-Binding Protein 1-Like Protein 3
  • Chromosome 1 Open Reading Frame 14 2
  • GE36 3

External Ids for SHCBP1L Gene

Previous HGNC Symbols for SHCBP1L Gene

  • C1orf14

Summaries for SHCBP1L Gene

GeneCards Summary for SHCBP1L Gene

SHCBP1L (SHC SH2-Domain Binding Protein 1-Like) is a Protein Coding gene. An important paralog of this gene is SHCBP1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHCBP1L Gene

Genomics for SHCBP1L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SHCBP1L Gene

Start:
182,899,865 bp from pter
End:
182,953,525 bp from pter
Size:
53,661 bases
Orientation:
Minus strand

Genomic View for SHCBP1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SHCBP1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHCBP1L Gene

No data available for Regulatory Elements for SHCBP1L Gene

Proteins for SHCBP1L Gene

  • Protein details for SHCBP1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZQ2-SHP1L_HUMAN
    Recommended name:
    SHC SH2 domain-binding protein 1-like protein
    Protein Accession:
    Q9BZQ2
    Secondary Accessions:
    • Q4G195
    • Q9BZQ3
    • Q9H2B6

    Protein attributes for SHCBP1L Gene

    Size:
    725 amino acids
    Molecular mass:
    80563 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SHCBP1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SHCBP1L Gene

Proteomics data for SHCBP1L Gene at MOPED

Post-translational modifications for SHCBP1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SHCBP1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHCBP1L Gene

Domains for SHCBP1L Gene

Suggested Antigen Peptide Sequences for SHCBP1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZQ2

UniProtKB/Swiss-Prot:

SHP1L_HUMAN :
  • Q9BZQ2
Similarity:
  • Contains 4 PbH1 repeats.
genes like me logo Genes that share domains with SHCBP1L: view

No data available for Gene Families for SHCBP1L Gene

Function for SHCBP1L Gene

Gene Ontology (GO) - Molecular Function for SHCBP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SHCBP1L: view

Phenotypes for SHCBP1L Gene

GenomeRNAi human phenotypes for SHCBP1L:
genes like me logo Genes that share phenotypes with SHCBP1L: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SHCBP1L

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SHCBP1L Gene

Localization for SHCBP1L Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SHCBP1L Gene

Pathways for SHCBP1L Gene

SuperPathways for SHCBP1L Gene

No Data Available

Interacting Proteins for SHCBP1L Gene

Gene Ontology (GO) - Biological Process for SHCBP1L Gene

None

No data available for Pathways by source for SHCBP1L Gene

Transcripts for SHCBP1L Gene

Unigene Clusters for SHCBP1L Gene

SHC SH2-domain binding protein 1-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SHCBP1L

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SHCBP1L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHCBP1L Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - -
SP2: - - -
SP3: -
SP4: -

Relevant External Links for SHCBP1L Gene

GeneLoc Exon Structure for
SHCBP1L
ECgene alternative splicing isoforms for
SHCBP1L

Expression for SHCBP1L Gene

mRNA expression in normal human tissues for SHCBP1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SHCBP1L Gene

This gene is overexpressed in Testis (52.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SHCBP1L Gene

SOURCE GeneReport for Unigene cluster for SHCBP1L Gene Hs.497034

mRNA Expression by UniProt/SwissProt for SHCBP1L Gene

Q9BZQ2-SHP1L_HUMAN
Tissue specificity: Highly expressed in the testis.
genes like me logo Genes that share expressions with SHCBP1L: view

In Situ Assay Products

Orthologs for SHCBP1L Gene

This gene was present in the common ancestor of animals.

Orthologs for SHCBP1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SHCBP1L 35
  • 99.39 (n)
  • 98.77 (a)
SHCBP1L 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C16H1ORF14 36
  • 86 (a)
OneToOne
SHCBP1L 35
  • 89.86 (n)
  • 86.33 (a)
dog
(Canis familiaris)
Mammalia SHCBP1L 35
  • 92.04 (n)
  • 91.85 (a)
SHCBP1L 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Shcbp1l 35
  • 81.41 (n)
  • 84.47 (a)
Shcbp1l 16
Shcbp1l 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SHCBP1L 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1ORF14 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Shcbp1l 35
  • 83 (n)
  • 86.63 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 61 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2784 35
fruit fly
(Drosophila melanogaster)
Insecta nesd 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToOne
Species with no ortholog for SHCBP1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SHCBP1L Gene

ENSEMBL:
Gene Tree for SHCBP1L (if available)
TreeFam:
Gene Tree for SHCBP1L (if available)

Paralogs for SHCBP1L Gene

Paralogs for SHCBP1L Gene

genes like me logo Genes that share paralogs with SHCBP1L: view

Variants for SHCBP1L Gene

Sequence variations from dbSNP and Humsavar for SHCBP1L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3123484 -- 182,915,294(+) ggcta(C/T)actaa intron-variant
rs3130493 -- 182,903,275(+) GTTAC(A/G)TGCAA intron-variant
rs3130494 -- 182,919,965(+) CCCTA(C/T)CAGCA intron-variant
rs3814325 -- 182,953,840(+) TGGTC(A/C)TACCA upstream-variant-2KB
rs4128654 -- 182,946,553(+) CATGT(A/G)GTTCC intron-variant

Relevant External Links for SHCBP1L Gene

HapMap Linkage Disequilibrium report
SHCBP1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SHCBP1L Gene

Disorders for SHCBP1L Gene

No disorders were found for SHCBP1L Gene.

No data available for UniProtKB/Swiss-Prot for SHCBP1L Gene

Publications for SHCBP1L Gene

  1. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. (PMID: 11318611) Sood R. … Carpten J.D. (Genomics 2001) 2 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. SHCBP1L, a conserved protein in mammals, is predominantly expressed in male germ cells and maintains spindle stability during meiosis in testis. (PMID: 24557841) Liu M. … Sha J. (Mol. Hum. Reprod. 2014) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4

Products for SHCBP1L Gene

Sources for SHCBP1L Gene

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