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Aliases for SHCBP1L Gene

Aliases for SHCBP1L Gene

  • SHC Binding And Spindle Associated 1 Like 2 3
  • SHC SH2-Domain Binding Protein 1-Like 2 3 5
  • SHC SH2 Domain-Binding Protein 1-Like Protein 3 4
  • C1orf14 3 4
  • Chromosome 1 Open Reading Frame 14 2
  • GE36 3

External Ids for SHCBP1L Gene

Previous HGNC Symbols for SHCBP1L Gene

  • C1orf14

Summaries for SHCBP1L Gene

GeneCards Summary for SHCBP1L Gene

SHCBP1L (SHC Binding And Spindle Associated 1 Like) is a Protein Coding gene. An important paralog of this gene is SHCBP1.

UniProtKB/Swiss-Prot for SHCBP1L Gene

  • Testis-specific spindle-associated factor that plays a role in spermatogenesis. In association with HSPA2, participates in the maintenance of spindle integrity during meiosis in male germ cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHCBP1L Gene

Genomics for SHCBP1L Gene

Regulatory Elements for SHCBP1L Gene

Promoters for SHCBP1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SHCBP1L on UCSC Golden Path with GeneCards custom track

Genomic Location for SHCBP1L Gene

182,899,865 bp from pter
182,953,525 bp from pter
53,661 bases
Minus strand

Genomic View for SHCBP1L Gene

Genes around SHCBP1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHCBP1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHCBP1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHCBP1L Gene

Proteins for SHCBP1L Gene

  • Protein details for SHCBP1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testicular spindle-associated protein SHCBP1L
    Protein Accession:
    Secondary Accessions:
    • Q4G195
    • Q9BZQ3
    • Q9H2B6

    Protein attributes for SHCBP1L Gene

    725 amino acids
    Molecular mass:
    80563 Da
    Quaternary structure:
    • Interacts with HSPA2; this interaction may promote the recruitment of HSPA2 to the spindle.

    Alternative splice isoforms for SHCBP1L Gene


neXtProt entry for SHCBP1L Gene

Proteomics data for SHCBP1L Gene at MOPED

Post-translational modifications for SHCBP1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SHCBP1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHCBP1L Gene

Domains & Families for SHCBP1L Gene

Suggested Antigen Peptide Sequences for SHCBP1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 PbH1 repeats.
  • Contains 4 PbH1 repeats.
genes like me logo Genes that share domains with SHCBP1L: view

No data available for Gene Families for SHCBP1L Gene

Function for SHCBP1L Gene

Molecular function for SHCBP1L Gene

UniProtKB/Swiss-Prot Function:
Testis-specific spindle-associated factor that plays a role in spermatogenesis. In association with HSPA2, participates in the maintenance of spindle integrity during meiosis in male germ cells.
genes like me logo Genes that share phenotypes with SHCBP1L: view

Animal Models for SHCBP1L Gene

MGI Knock Outs for SHCBP1L:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SHCBP1L Gene

Localization for SHCBP1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHCBP1L Gene

Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with alpha tubulin during meiosis. Colocalizes with HSPA2 at spindle during the meiosis process. {ECO:0000250 UniProtKB:Q3TTP0}.

Subcellular locations from

Jensen Localization Image for SHCBP1L Gene COMPARTMENTS Subcellular localization image for SHCBP1L gene
Compartment Confidence
cytoskeleton 4
cytosol 3
golgi apparatus 2
plasma membrane 2
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for SHCBP1L Gene

Pathways & Interactions for SHCBP1L Gene

SuperPathways for SHCBP1L Gene

No Data Available

Interacting Proteins for SHCBP1L Gene

Gene Ontology (GO) - Biological Process for SHCBP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:2001252 positive regulation of chromosome organization IEA,ISS --
genes like me logo Genes that share ontologies with SHCBP1L: view

No data available for Pathways by source and SIGNOR curated interactions for SHCBP1L Gene

Drugs & Compounds for SHCBP1L Gene

No Compound Related Data Available

Transcripts for SHCBP1L Gene

Unigene Clusters for SHCBP1L Gene

SHC SH2-domain binding protein 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SHCBP1L Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - -
SP2: - - -
SP3: -
SP4: -

Relevant External Links for SHCBP1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SHCBP1L Gene

mRNA expression in normal human tissues for SHCBP1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SHCBP1L Gene

This gene is overexpressed in Testis (x52.5).

Protein differential expression in normal tissues from HIPED for SHCBP1L Gene

This gene is overexpressed in Testis (43.2) and Ovary (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SHCBP1L Gene

SOURCE GeneReport for Unigene cluster for SHCBP1L Gene Hs.497034

mRNA Expression by UniProt/SwissProt for SHCBP1L Gene

Tissue specificity: Expressed in spermatocytes and elongating spermatids inside the seminiferous tubules (at protein level) (PubMed:24557841). Testis-specific (PubMed:11318611, PubMed:24557841).
genes like me logo Genes that share expression patterns with SHCBP1L: view

Protein tissue co-expression partners for SHCBP1L Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SHCBP1L Gene

This gene was present in the common ancestor of animals.

Orthologs for SHCBP1L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SHCBP1L 35
  • 89.86 (n)
  • 86.33 (a)
C16H1ORF14 36
  • 86 (a)
(Canis familiaris)
Mammalia SHCBP1L 35
  • 92.04 (n)
  • 91.85 (a)
  • 83 (a)
(Mus musculus)
Mammalia Shcbp1l 35
  • 81.41 (n)
  • 84.47 (a)
Shcbp1l 16
Shcbp1l 36
  • 82 (a)
(Pan troglodytes)
Mammalia SHCBP1L 35
  • 99.39 (n)
  • 98.77 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Shcbp1l 35
  • 83 (n)
  • 86.63 (a)
(Monodelphis domestica)
Mammalia SHCBP1L 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia C1ORF14 36
  • 78 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 61 (a)
-- 36
  • 60 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2784 35
fruit fly
(Drosophila melanogaster)
Insecta nesd 36
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
Species with no ortholog for SHCBP1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SHCBP1L Gene

Gene Tree for SHCBP1L (if available)
Gene Tree for SHCBP1L (if available)

Paralogs for SHCBP1L Gene

Paralogs for SHCBP1L Gene

genes like me logo Genes that share paralogs with SHCBP1L: view

Variants for SHCBP1L Gene

Sequence variations from dbSNP and Humsavar for SHCBP1L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12138972 - 182,904,296(+) CTCCA(C/T)CACCA reference, missense
rs3130493 -- 182,903,275(+) GTTAC(A/G)TGCAA intron-variant
rs3130494 -- 182,919,965(+) CCCTA(C/T)CAGCA intron-variant
rs3814325 -- 182,953,840(+) TGGTC(A/C)TACCA upstream-variant-2KB
rs3123484 -- 182,915,294(+) ggcta(C/T)actaa intron-variant

Variation tolerance for SHCBP1L Gene

Residual Variation Intolerance Score: 89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.43; 71.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SHCBP1L Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SHCBP1L Gene

Disorders for SHCBP1L Gene

Relevant External Links for SHCBP1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SHCBP1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHCBP1L Gene

Publications for SHCBP1L Gene

  1. SHCBP1L, a conserved protein in mammals, is predominantly expressed in male germ cells and maintains spindle stability during meiosis in testis. (PMID: 24557841) Liu M. … Sha J. (Mol. Hum. Reprod. 2014) 2 3 4 67
  2. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. (PMID: 11318611) Sood R. … Carpten J.D. (Genomics 2001) 2 3
  3. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J. … Elledge S.J. (Cell 2009) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SHCBP1L Gene

Sources for SHCBP1L Gene

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