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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SHCBP1L Gene

protein-coding   GIFtS: 41
GCID: GC01M182870

SHC SH2-Domain Binding Protein 1-Like

(Previous name: chromosome 1 open reading frame 14)
(Previous symbol: C1orf14)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SHC SH2-Domain Binding Protein 1-Like1 2
C1orf141 2 3
Chromosome 1 Open Reading Frame 141
GE362
SHC SH2 Domain-Binding Protein 1-Like Protein2

External Ids:    HGNC: 167881   Entrez Gene: 816262   Ensembl: ENSG000001570607   UniProtKB: Q9BZQ23   

Export aliases for SHCBP1L gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SHCBP1L Gene: 
SHCBP1L (SHC SH2-domain binding protein 1-like) is a protein-coding gene. Diseases associated with SHCBP1L include prostate cancer, and prostatitis. An important paralog of this gene is SHCBP1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SHCBP1L
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SHCBP1L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHCBP1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.3   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25

SHCBP1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHCBP1L gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M182870:  view genomic region     (about GC identifiers)

Start:
182,869,000 bp from pter      End:
182,922,660 bp from pter
Size:
53,661 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SHP1L_HUMAN, Q9BZQ2 (See protein sequence)
Recommended Name: SHC SH2 domain-binding protein 1-like protein  
Size: 725 amino acids; 80563 Da
Secondary accessions: Q4G195 Q9BZQ3 Q9H2B6
Alternative splicing: 4 isoforms:  Q9BZQ2-1   Q9BZQ2-2   Q9BZQ2-3   Q9BZQ2-4   (Contains a phosphoserine at position 8)

Explore the universe of human proteins at neXtProt for SHCBP1L: NX_Q9BZQ2

Explore proteomics data for SHCBP1L at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BZQ2

  • SHCBP1L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SHCBP1L Protein Expression
    REFSEQ proteins: NP_112195.2  
    ENSEMBL proteins: 
     ENSP00000356518   ENSP00000397308  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR012334 Pectin_lyas_fold
     IPR006633 Carb-bd_sugar_hydrolysis-dom
     IPR011050 Pectin_lyase_fold/virulence
     IPR006626 PbH1

    Graphical View of Domain Structure for InterPro Entry Q9BZQ2

    ProtoNet protein and cluster: Q9BZQ2

    1 Blocks protein domain: IPB006626 Parallel beta-helix repeat

    UniProtKB/Swiss-Prot: SHP1L_HUMAN, Q9BZQ2
    Similarity: Contains 4 PbH1 repeats


    SHCBP1L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for SHCBP1L:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SHCBP1L 
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHCBP1L


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SHCBP1L

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SHCBP1L (SHP1L)

    Search CenterWatch for drugs/clinical trials and news about SHCBP1L / SHP1L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SHCBP1L gene: 
    NM_030933.2  

    Unigene Cluster for SHCBP1L:

    SHC SH2-domain binding protein 1-like
    Hs.497034  [show with all ESTs]
    Unigene Representative Sequence: BC026084
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483655 ENST00000367547 ENST00000488956(uc001gpu.3 uc001gpv.3 uc010pnz.2 uc001gpw.3)
    ENST00000467208 ENST00000497549 ENST00000423786
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SHCBP1L:
    hsa-miR-7-1* hsa-miR-7-2*
    SwitchGear 3'UTR luciferase reporter plasmidSHCBP1L 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SHCBP1L
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SHCBP1L

    Additional mRNA sequence: 

    AF288397.1 AF288398.1 BC026084.1 BC026086.1 BC050305.1 BC132764.1 BC144326.1 

    4 DOTS entries:

    DT.306245  DT.101970389  DT.100654964  DT.95074553 

    24/48 AceView cDNA sequences (see all 48):

    AA398369 BF222704 BC026086 AI982792 BF057803 AI223334 BC026084 AI041091 
    AA868975 AA397535 AW590382 BG720817 BE501072 NM_030933 BG771693 AI352586 
    AA431804 AW873520 AA399508 AF288398 AW510979 BQ438386 BI553647 BG773206 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SHCBP1L    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:              -     -                                                                     
    SP2:              -     -                       -                                             
    SP3:              -                                                                           
    SP4:                    -                                                                     


    ECgene alternative splicing isoforms for SHCBP1L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SHCBP1L expression in normal human tissues (normalized intensities)      SHCBP1L embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTCTCATAC
    SHCBP1L Expression
    About this image


    SHCBP1L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
             sperm   
     
     Gonad
             Primordial Germ Cells Allantois
     
     Placenta (Extraembryonic Tissues)
             Primordial Germ Cells Allantois

    See SHCBP1L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SHCBP1L

    SOURCE GeneReport for Unigene cluster: Hs.497034

    UniProtKB/Swiss-Prot: SHP1L_HUMAN, Q9BZQ2
    Tissue specificity: Highly expressed in the testis

        SABiosciences Custom PCR Arrays for SHCBP1L
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHCBP1L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SHCBP1L gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Shcbp1l1 , 5 RIKEN cDNA 1700012A16 gene5
    Shc SH2-domain binding protein 1-like1
    81.51(n)1
    84.63(a)1
      1 (65.36 cM)5
    718361  NM_001033162.21  NP_001028334.11 
     1534251625 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    62(a)
    60(a)
    1 ↔ many
    1 ↔ many
    GL343203.1(4605215-4627520)
    GL343568.1(129926-131074)
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.27842 Oncorhynchus mykiss transcribed sequence with weak more 70.52(n)    BX086338.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nesd6
    nessun dorma
    16(a)
    1 → many
    2L(20093972-20096253)


    ENSEMBL Gene Tree for SHCBP1L (if available)
    TreeFam Gene Tree for SHCBP1L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SHCBP1L gene
    SHCBP12  

    SHCBP1L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1051 SNPs in SHCBP1L are shown (see all 1051)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs610312171,2
    C--154109391(+) GTGTG-/TG    
       
    /TGTG
    CGCAT
    1 -- int11NA 2
    rs1410092661,2
    --182868515(+) CTACGC/TTGAGT 1 -- int10--------
    rs1892024361,2
    C--182868607(+) TCTTAC/TTTTGG 1 -- int10--------
    rs727270531,2
    --182868641(+) ATCTAC/TCCTAT 1 -- int10--------
    rs1809331351,2
    --182868680(+) AAAATA/GTATAA 1 -- int10--------
    rs1842446871,2
    --182868817(+) ATTAGA/TAAACA 1 -- int10--------
    rs1899819061,2
    --182868886(+) AATATA/GCTAAT 1 -- int10--------
    rs1812458931,2
    C--182869085(+) TTTGTG/AAAATA 1 -- ut311Minor allele frequency- A:0.00EU 1251
    rs1512615381,2
    C,F--182869122(+) TTTAAC/TTTGTG 2 N S mis12Minor allele frequency- T:0.00NA EU 5785
    rs344319751,2
    C--182869126(+) ACTTGT/GGACTA 2 /T /P mis12Minor allele frequency- G:0.00NA 4

    HapMap Linkage Disequilibrium report for SHCBP1L (182869000 - 182922660 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SHCBP1L: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SHCBP1L
    DNA2.0 Custom Variant and Variant Library Synthesis for SHCBP1L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for SHCBP1L:    About MalaCards
    prostate cancer    prostatitis


    SHCBP1L for disorders           About GeneDecksing


    Export disorders for SHCBP1L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SHCBP1L gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SHCBP1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. (PubMed id 11318611)1, 2, 3 Sood R....Carpten J.D. (2001)
    2. Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81626 HGNC: 16788 AceView: C1orf14 Ensembl:ENSG00000157060 euGenes: HUgn81626
    ECgene: SHCBP1L H-InvDB: SHCBP1L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SHCBP1L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SHCBP1L gene:
    Search GeneIP for patents involving SHCBP1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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