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Aliases for SHCBP1 Gene

Aliases for SHCBP1 Gene

  • SHC SH2-Domain Binding Protein 1 2 3
  • PAL 3 6
  • SHC SH2 Domain-Binding Protein 1 3

External Ids for SHCBP1 Gene

Previous GeneCards Identifiers for SHCBP1 Gene

  • GC16M037025
  • GC16M046555
  • GC16M046354
  • GC16M046395
  • GC16M045171
  • GC16M032503

Summaries for SHCBP1 Gene

GeneCards Summary for SHCBP1 Gene

SHCBP1 (SHC SH2-Domain Binding Protein 1) is a Protein Coding gene. GO annotations related to this gene include SH2 domain binding. An important paralog of this gene is SHCBP1L.

UniProtKB/Swiss-Prot for SHCBP1 Gene

  • May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells (By similarity).

Gene Wiki entry for SHCBP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHCBP1 Gene

Genomics for SHCBP1 Gene

Regulatory Elements for SHCBP1 Gene

Genomic Location for SHCBP1 Gene

46,580,554 bp from pter
46,621,626 bp from pter
41,073 bases
Minus strand

Genomic View for SHCBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SHCBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHCBP1 Gene

Proteins for SHCBP1 Gene

  • Protein details for SHCBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SHC SH2 domain-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • Q96N60
    • Q9BVS0
    • Q9H6P6

    Protein attributes for SHCBP1 Gene

    672 amino acids
    Molecular mass:
    75690 Da
    Quaternary structure:
    • Interacts directly with isoform p52shc of SHC1 via its SH2 domain. Interacts with TRIM71; leading to enhance SHCBP1 protein stability (By similarity).
    • Sequence=BAB15208.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for SHCBP1 Gene

Proteomics data for SHCBP1 Gene at MOPED

Post-translational modifications for SHCBP1 Gene

  • Ubiquitination at Lys296, Lys300, Lys315, and Lys517
  • Modification sites at PhosphoSitePlus

Other Protein References for SHCBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHCBP1 Gene

Domains for SHCBP1 Gene

Protein Domains for SHCBP1 Gene

Suggested Antigen Peptide Sequences for SHCBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8NEM2
  • Contains 5 PbH1 repeats.
genes like me logo Genes that share domains with SHCBP1: view

No data available for Gene Families for SHCBP1 Gene

Function for SHCBP1 Gene

Molecular function for SHCBP1 Gene

UniProtKB/Swiss-Prot Function: May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells (By similarity).

Gene Ontology (GO) - Molecular Function for SHCBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0042169 SH2 domain binding IEA --
genes like me logo Genes that share ontologies with SHCBP1: view

Phenotypes for SHCBP1 Gene

MGI mutant phenotypes for SHCBP1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SHCBP1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SHCBP1 Gene

Localization for SHCBP1 Gene

Subcellular locations from

Jensen Localization Image for SHCBP1 Gene COMPARTMENTS Subcellular localization image for SHCBP1 gene
Compartment Confidence
cytosol 2
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SHCBP1 Gene

Pathways for SHCBP1 Gene

SuperPathways for SHCBP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SHCBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008543 fibroblast growth factor receptor signaling pathway ISS --
GO:2000177 regulation of neural precursor cell proliferation ISS --
genes like me logo Genes that share ontologies with SHCBP1: view

No data available for Pathways by source for SHCBP1 Gene

Transcripts for SHCBP1 Gene

Unigene Clusters for SHCBP1 Gene

SHC SH2-domain binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SHCBP1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SHCBP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHCBP1 Gene

No ASD Table

Relevant External Links for SHCBP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SHCBP1 Gene

mRNA expression in normal human tissues for SHCBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SHCBP1 Gene

SOURCE GeneReport for Unigene cluster for SHCBP1 Gene Hs.123253

genes like me logo Genes that share expressions with SHCBP1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SHCBP1 Gene

Orthologs for SHCBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SHCBP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SHCBP1 35
  • 99.7 (n)
  • 99.4 (a)
  • 99 (a)
(Bos Taurus)
Mammalia SHCBP1 35
  • 90.17 (n)
  • 90.32 (a)
  • 90 (a)
(Canis familiaris)
Mammalia SHCBP1 35
  • 89.64 (n)
  • 89.04 (a)
  • 88 (a)
(Mus musculus)
Mammalia Shcbp1 35
  • 82.88 (n)
  • 78.29 (a)
Shcbp1 16
Shcbp1 36
  • 78 (a)
(Monodelphis domestica)
Mammalia SHCBP1 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
-- 36
  • 77 (a)
(Rattus norvegicus)
Mammalia Shcbp1 35
  • 82.78 (n)
  • 78.29 (a)
(Gallus gallus)
Aves SHCBP1 35
  • 73.76 (n)
  • 75.24 (a)
  • 68 (a)
(Anolis carolinensis)
Reptilia SHCBP1 36
  • 63 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13015 35
tropical clawed frog
(Silurana tropicalis)
Amphibia shcbp1 35
  • 67.24 (n)
  • 63.85 (a)
Str.10946 35
(Danio rerio)
Actinopterygii shcbp1 35
  • 60.95 (n)
  • 57.93 (a)
shcbp1 36
  • 48 (a)
wufi22a03 35
fruit fly
(Drosophila melanogaster)
Insecta nesd 36
  • 18 (a)
Species with no ortholog for SHCBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHCBP1 Gene

Gene Tree for SHCBP1 (if available)
Gene Tree for SHCBP1 (if available)

Paralogs for SHCBP1 Gene

Paralogs for SHCBP1 Gene Pseudogenes for SHCBP1 Gene

genes like me logo Genes that share paralogs with SHCBP1: view

Variants for SHCBP1 Gene

Sequence variations from dbSNP and Humsavar for SHCBP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs744091 -- 46,612,905(-) gtggt(C/T)gagtg intron-variant
rs1054722 -- 46,581,450(-) CTGGT(A/G)GTAAC utr-variant-3-prime
rs1369935 -- 46,582,739(-) GCTGG(A/G)CAGGA intron-variant
rs1532752 -- 46,620,758(-) ACCGG(A/G)GTCTT intron-variant
rs1583539 -- 46,594,602(-) ctcaa(A/G)agcat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SHCBP1 Gene

Variant ID Type Subtype PubMed ID
nsv833216 CNV Loss 17160897
nsv526656 CNV Gain 19592680
nsv428327 CNV Gain 18775914

Relevant External Links for SHCBP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHCBP1 Gene

Disorders for SHCBP1 Gene

No disorders were found for SHCBP1 Gene.

No data available for UniProtKB/Swiss-Prot for SHCBP1 Gene

Publications for SHCBP1 Gene

  1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  2. Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells. (PMID: 10086341) Schmandt R. … McGlade C.J. (Oncogene 1999) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. (PMID: 15778465) Benzinger A. … Hermeking H. (Mol. Cell. Proteomics 2005) 3

Products for SHCBP1 Gene

Sources for SHCBP1 Gene

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