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SHCBP1 Gene

protein-coding   GIFtS: 52
GCID: GC16M046614

SHC SH2-Domain Binding Protein 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SHC SH2-Domain Binding Protein 11 2
PAL2 5
SHC SH2 Domain-Binding Protein 12

External Ids:    HGNC: 295471   Entrez Gene: 798012   Ensembl: ENSG000001712417   OMIM: 6110275   UniProtKB: Q8NEM23   

Export aliases for SHCBP1 gene to outside databases

Previous GC identifers: GC16M037025 GC16M046555 GC16M046354 GC16M046395 GC16M045171 GC16M032503


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SHCBP1 Gene:
SHCBP1 (SHC SH2-domain binding protein 1) is a protein-coding gene. GO annotations related to this gene include SH2 domain binding. An important paralog of this gene is SHCBP1L.

UniProtKB/Swiss-Prot: SHCBP_HUMAN, Q8NEM2
Function: May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation.
May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling
in neural progenitor cells (By similarity)

Gene Wiki entry for SHCBP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SHCBP1 gene promoter:
         Pax-5   AML1a   Nkx5-1   NF-kappaB   FOXL1   POU2F1   POU2F1a   FOXO1a   NF-kappaB1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSHCBP1 promoter sequence
   Search Chromatin IP Primers for SHCBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SHCBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q11.2   Ensembl cytogenetic band:  16q11.2   HGNC cytogenetic band: 16q11

SHCBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHCBP1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M046614:  view genomic region     (about GC identifiers)

Start:
46,614,466 bp from pter      End:
46,655,538 bp from pter
Size:
41,073 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SHCBP_HUMAN, Q8NEM2 (See protein sequence)
Recommended Name: SHC SH2 domain-binding protein 1  
Size: 672 amino acids; 75690 Da
Subunit: Interacts directly with isoform p52shc of SHC1 via its SH2 domain. Interacts with TRIM71; leading to
enhance SHCBP1 protein stability (By similarity)
Sequence caution: Sequence=BAB15208.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q96N60 Q9BVS0 Q9H6P6

Explore the universe of human proteins at neXtProt for SHCBP1: NX_Q8NEM2

Explore proteomics data for SHCBP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys296, Lys300, Lys315, Lys517
  • Modification sites at PhosphoSitePlus

  • See SHCBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079021.3  
    ENSEMBL proteins: 
     ENSP00000306473   ENSP00000460840  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR012334 Pectin_lyas_fold
     IPR011050 Pectin_lyase_fold/virulence
     IPR006626 PbH1

    Graphical View of Domain Structure for InterPro Entry Q8NEM2

    ProtoNet protein and cluster: Q8NEM2

    1 Blocks protein domain: IPB006626 Parallel beta-helix repeat

    UniProtKB/Swiss-Prot: SHCBP_HUMAN, Q8NEM2
    Similarity: Contains 5 PbH1 repeats


    Find genes that share domains with SHCBP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SHCBP_HUMAN, Q8NEM2
    Function: May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation.
    May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling
    in neural progenitor cells (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0042169SH2 domain binding IEA--
         
    Find genes that share ontologies with SHCBP1           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Shcbp1):
     no phenotypic analysis 

    Find genes that share phenotypes with SHCBP1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SHCBP1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SHCBP1
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    miRNA
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    miRTarBase miRNAs that target SHCBP1:
    hsa-mir-340-5p (MIRT019604), hsa-mir-455-3p (MIRT037830), hsa-mir-425-5p (MIRT016655), hsa-mir-877-3p (MIRT037132), hsa-mir-32-5p (MIRT028313), hsa-mir-33a-5p (MIRT028215), hsa-mir-19b-3p (MIRT031291), hsa-mir-193b-3p (MIRT016445)

    Block miRNA regulation of human, mouse, rat SHCBP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SHCBP1 (see all 24):
    hsa-miR-4291 hsa-miR-302d hsa-miR-520e hsa-miR-302e hsa-miR-515-5p hsa-miR-520a-3p hsa-miR-372 hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidSHCBP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SHCBP1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHCBP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SHCBP1
    Interactions:

        GeneGlobe Interaction Network for SHCBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for SHCBP1 (Q8NEM22, 3 ENSP000003064734) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZUFSPQ96AP42, 3, ENSP000003575654MINT-66550 I2D: score=3 STRING: ENSP00000357565
    SFNP319472, 3MINT-3975636 I2D: score=2 
    YWHAGP619812, 3, ENSP000003063304MINT-50847 I2D: score=3 STRING: ENSP00000306330
    SHC1P293533, ENSP000004013034I2D: score=5 STRING: ENSP00000401303
    USP49Q70CQ13, ENSP000002972294I2D: score=2 STRING: ENSP00000297229
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008543fibroblast growth factor receptor signaling pathway ISS--
    GO:2000177regulation of neural precursor cell proliferation ISS--

    Find genes that share ontologies with SHCBP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SHCBP1 (SHCBP)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SHCBP1 gene: 
    NM_024745.4  

    Unigene Cluster for SHCBP1:

    SHC SH2-domain binding protein 1
    Hs.123253  [show with all ESTs]
    Unigene Representative Sequence: NM_024745
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303383(uc002eec.4) ENST00000567698 ENST00000563219 ENST00000569702
    ENST00000566016 ENST00000565887 ENST00000564272
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SHCBP1 (see all 24):
    hsa-miR-4291 hsa-miR-302d hsa-miR-520e hsa-miR-302e hsa-miR-515-5p hsa-miR-520a-3p hsa-miR-372 hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidSHCBP1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SHCBP1
      QuantiFast Probe-based Assays in human, mouse, rat SHCBP1

    Additional mRNA sequence: 

    AK025662.1 AK055931.1 AK225315.1 AK292164.1 AK310430.1 AK315706.1 BC000960.1 BC030699.1 

    5 DOTS entries:

    DT.311131  DT.102823095  DT.100701561  DT.91801056  DT.101966797 

    Selected AceView cDNA sequences (see all 62):

    BC000960 BX103548 AA401234 CA421392 AA346154 BF516062 AA346159 CF131576 
    BE464176 BG504190 CB145723 BG388411 BX494958 AA424274 BG253352 BI495145 
    NM_024745 AA701593 BC030699 BI495127 BP354371 BE543065 AA346160 AA744496 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SHCBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGTTCCAGC
    SHCBP1 Expression
    About this image


    SHCBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Endothelial Cells Blood Brain Barrier
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Fibroblasts (Uncategorized)
             Cardiac Fibroblasts Myocardium
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
    SHCBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SHCBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.123253
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SHCBP1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Shcbp11 , 5 Shc SH2-domain binding protein 11, 5 82.88(n)1
    78.29(a)1
      8 (2.09 cM)5
    204191  NM_011369.21  NP_035499.11 
     47359805 
    chicken
    (Gallus gallus)
    Aves SHCBP11 SHC SH2-domain binding protein 1 73.76(n)
    75.24(a)
      415751  XM_003641935.2  XP_003641983.1 
    lizard
    (Anolis carolinensis)
    Reptilia SHCBP16
    SHC SH2-domain binding protein 1
    63(a)
    1 ↔ 1
    LGc(3733022-3774010)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.130152 Xenopus laevis transcribed sequence with weak similarity more 75.23(n)    BU913535.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi22a032 wufi22a03 74.34(n)   333933  BC057538.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nesd6
    nessun dorma
    18(a)
    1 → many
    2L(20093972-20096253)


    ENSEMBL Gene Tree for SHCBP1 (if available)
    TreeFam Gene Tree for SHCBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SHCBP1 gene
    SHCBP1L2  

    Find genes that share paralogs with SHCBP1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SHCBP1
    PGOHUM00000234277


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SHCBP1 (see all 725)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1487257541,2
    --46613973(+) TGGAGA/GTTACA 1 -- int10--------
    rs1995919961,2
    --46614116(+) AAATT-/AAAAAA 1 -- int10--------
    rs1873943891,2
    --46614402(+) TAAATG/TACCAC 1 -- int10--------
    rs1147229651,2
    C,F--46614478(+) ATTTCA/CTCACT 1 -- ut311Minor allele frequency- C:0.03WA 118
    rs129286181,2
    C,F,H--46614595(+) TTGTAC/TAGTTA 1 -- ut3112Minor allele frequency- T:0.02NS EA NA 1376
    rs1923772801,2
    --46615022(+) CAACAC/TTGGCT 1 -- ut310--------
    rs1426906381,2
    --46615039(+) AACACA/GTTTCA 1 -- ut310--------
    rs1509985341,2
    --46615076(+) CTATCA/GCTGTT 1 -- ut310--------
    rs118633271,2
    C,F,H--46615096(+) GCATAG/CCTCAA 1 -- ut316Minor allele frequency- C:0.02NS EA NA WA 538
    rs1837801201,2
    --46615124(+) TTGACC/GTCTCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SHCBP1 (46614466 - 46655538 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SHCBP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833216CNV Loss17160897
    nsv428327CNV Gain18775914
    nsv526656CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SHCBP1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611027    OMIM disorders: --


    Find genes that share disorders with SHCBP1           About GenesLikeMe


    Export disorders for SHCBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SHCBP1 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with SHCBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells. (PubMed id 10086341)1, 3 Schmandt R....McGlade C.J. (Oncogene 1999)
    5. Measles virus nonstructural C protein modulates viral RNA polymerase activity by interacting with host protein SHCBP1. (PubMed id 23804634)1 Ito M....Ohno S. (J. Virol. 2013)
    6. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79801 HGNC: 29547 AceView: SHCBP1 Ensembl:ENSG00000171241 euGenes: HUgn79801
    ECgene: SHCBP1 H-InvDB: SHCBP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SHCBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SHCBP1 gene:
    Search GeneIP for patents involving SHCBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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