Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SHCBP1 Gene

Aliases for SHCBP1 Gene

  • SHC SH2-Domain Binding Protein 1 2 3
  • PAL 3 6
  • SHC SH2 Domain-Binding Protein 1 3

External Ids for SHCBP1 Gene

Summaries for SHCBP1 Gene

GeneCards Summary for SHCBP1 Gene

SHCBP1 (SHC SH2-Domain Binding Protein 1) is a Protein Coding gene. GO annotations related to this gene include SH2 domain binding. An important paralog of this gene is SHCBP1L.

UniProtKB/Swiss-Prot for SHCBP1 Gene

  • May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells (By similarity).

Gene Wiki entry for SHCBP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHCBP1 Gene

Genomics for SHCBP1 Gene

Genomic Location for SHCBP1 Gene

Start:
46,580,554 bp from pter
End:
46,621,626 bp from pter
Size:
41,073 bases
Orientation:
Minus strand

Genomic View for SHCBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SHCBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHCBP1 Gene

Regulatory Elements for SHCBP1 Gene

Proteins for SHCBP1 Gene

  • Protein details for SHCBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEM2-SHCBP_HUMAN
    Recommended name:
    SHC SH2 domain-binding protein 1
    Protein Accession:
    Q8NEM2
    Secondary Accessions:
    • Q96N60
    • Q9BVS0
    • Q9H6P6

    Protein attributes for SHCBP1 Gene

    Size:
    672 amino acids
    Molecular mass:
    75690 Da
    Quaternary structure:
    • Interacts directly with isoform p52shc of SHC1 via its SH2 domain. Interacts with TRIM71; leading to enhance SHCBP1 protein stability (By similarity).
    SequenceCaution:
    • Sequence=BAB15208.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for SHCBP1 Gene

Proteomics data for SHCBP1 Gene at MOPED

Post-translational modifications for SHCBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys296, Lys300, Lys315, and Lys517

Other Protein References for SHCBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHCBP1 Gene

Domains for SHCBP1 Gene

Protein Domains for SHCBP1 Gene

UniProtKB/Swiss-Prot:

SHCBP_HUMAN
Similarity:
  • Contains 5 PbH1 repeats.:
    • Q8NEM2
genes like me logo Genes that share domains with SHCBP1: view

No data available for Gene Families for SHCBP1 Gene

Function for SHCBP1 Gene

Molecular function for SHCBP1 Gene

UniProtKB/Swiss-Prot Function: May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells (By similarity).

Gene Ontology (GO) - Molecular Function for SHCBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0042169 SH2 domain binding IEA --
genes like me logo Genes that share ontologies with SHCBP1: view

Phenotypes for SHCBP1 Gene

MGI mutant phenotypes for SHCBP1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SHCBP1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SHCBP1 Gene

Localization for SHCBP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SHCBP1 Gene COMPARTMENTS Subcellular localization image for SHCBP1 gene
Compartment Confidence
cytosol 2
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SHCBP1 Gene

Pathways for SHCBP1 Gene

SuperPathways for SHCBP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SHCBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008543 fibroblast growth factor receptor signaling pathway ISS --
GO:2000177 regulation of neural precursor cell proliferation ISS --
genes like me logo Genes that share ontologies with SHCBP1: view

No data available for Pathways by source for SHCBP1 Gene

Transcripts for SHCBP1 Gene

Unigene Clusters for SHCBP1 Gene

SHC SH2-domain binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SHCBP1 Gene

No ASD Table

Relevant External Links for SHCBP1 Gene

GeneLoc Exon Structure for
SHCBP1
ECgene alternative splicing isoforms for
SHCBP1

Expression for SHCBP1 Gene

mRNA expression in normal human tissues for SHCBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SHCBP1 Gene

SOURCE GeneReport for Unigene cluster for SHCBP1 Gene Hs.123253

genes like me logo Genes that share expressions with SHCBP1: view

Orthologs for SHCBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SHCBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SHCBP1 36
  • 99.7 (n)
  • 99.4 (a)
SHCBP1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SHCBP1 36
  • 90.17 (n)
  • 90.32 (a)
SHCBP1 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SHCBP1 36
  • 89.64 (n)
  • 89.04 (a)
SHCBP1 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Shcbp1 36
  • 82.88 (n)
  • 78.29 (a)
Shcbp1 16
Shcbp1 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SHCBP1 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 76 (a)
OneToMany
-- 37
  • 77 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Shcbp1 36
  • 82.78 (n)
  • 78.29 (a)
chicken
(Gallus gallus)
Aves SHCBP1 36
  • 73.76 (n)
  • 75.24 (a)
SHCBP1 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SHCBP1 37
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13015 36
tropical clawed frog
(Silurana tropicalis)
Amphibia shcbp1 36
  • 67.24 (n)
  • 63.85 (a)
Str.10946 36
zebrafish
(Danio rerio)
Actinopterygii shcbp1 36
  • 60.95 (n)
  • 57.93 (a)
shcbp1 37
  • 48 (a)
OneToOne
wufi22a03 36
fruit fly
(Drosophila melanogaster)
Insecta nesd 37
  • 18 (a)
OneToMany
Species with no ortholog for SHCBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHCBP1 Gene

ENSEMBL:
Gene Tree for SHCBP1 (if available)
TreeFam:
Gene Tree for SHCBP1 (if available)

Paralogs for SHCBP1 Gene

Paralogs for SHCBP1 Gene

Pseudogenes.org Pseudogenes for SHCBP1 Gene

genes like me logo Genes that share paralogs with SHCBP1: view

Variants for SHCBP1 Gene

Sequence variations from dbSNP and Humsavar for SHCBP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs744091 -- 46,612,905(-) gtggt(C/T)gagtg intron-variant
rs1054722 -- 46,581,450(-) CTGGT(A/G)GTAAC utr-variant-3-prime
rs1369935 -- 46,582,739(-) GCTGG(A/G)CAGGA intron-variant
rs1532752 -- 46,620,758(-) ACCGG(A/G)GTCTT intron-variant
rs1583539 -- 46,594,602(-) ctcaa(A/G)agcat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SHCBP1 Gene

Variant ID Type Subtype PubMed ID
nsv833216 CNV Loss 17160897
nsv526656 CNV Gain 19592680
nsv428327 CNV Gain 18775914

Relevant External Links for SHCBP1 Gene

HapMap Linkage Disequilibrium report
SHCBP1

Disorders for SHCBP1 Gene

No disorders were found for SHCBP1 Gene.

No data available for UniProtKB/Swiss-Prot for SHCBP1 Gene

Publications for SHCBP1 Gene

  1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  2. Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells. (PMID: 10086341) Schmandt R. … McGlade C.J. (Oncogene 1999) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. (PMID: 15778465) Benzinger A. … Hermeking H. (Mol. Cell. Proteomics 2005) 3

Products for SHCBP1 Gene

Sources for SHCBP1 Gene

Back to Top

Content