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Aliases for SHCBP1 Gene

Aliases for SHCBP1 Gene

  • SHC Binding And Spindle Associated 1 2 3 5
  • Protein Expressed In Activated Lymphocytes 2 3
  • SHC SH2-Domain Binding Protein 1 2
  • SHC SH2 Domain-Binding Protein 1 3
  • PAL 3

External Ids for SHCBP1 Gene

Previous GeneCards Identifiers for SHCBP1 Gene

  • GC16M037025
  • GC16M046555
  • GC16M046354
  • GC16M046395
  • GC16M045171
  • GC16M032503

Summaries for SHCBP1 Gene

GeneCards Summary for SHCBP1 Gene

SHCBP1 (SHC Binding And Spindle Associated 1) is a Protein Coding gene. Among its related pathways are MAPK-Erk Pathway and Jak-Stat Signaling Pathway (sino). GO annotations related to this gene include SH2 domain binding. An important paralog of this gene is SHCBP1L.

UniProtKB/Swiss-Prot for SHCBP1 Gene

  • May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.

Gene Wiki entry for SHCBP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHCBP1 Gene

Genomics for SHCBP1 Gene

Regulatory Elements for SHCBP1 Gene

Enhancers for SHCBP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G046742 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.5 -120.4 -120440 1.7 TBP HDGF HDAC1 PKNOX1 ATF1 CBX3 NFRKB ZSCAN4 SIN3A ZBTB40 MYLK3 ENSG00000261131 SHCBP1 GC16M046768 GC16P046705
GH16G046788 1.4 FANTOM5 ENCODE 14.7 -167.2 -167225 2.1 HDGF PKNOX1 FOXA2 CREB3L1 AGO1 ZFP64 ARID4B DMAP1 BRCA1 ZNF2 SHCBP1 MYLK3 LOC100130180
GH16G046756 1.4 FANTOM5 ENCODE dbSUPER 14 -134.6 -134603 1.7 ZSCAN4 DMAP1 RAD21 ZNF2 ZNF335 ZNF121 SCRT2 GATAD2B REST NR2F2 SHCBP1 C16orf87 ORC6 GC16M046768 GC16P046705
GH16G046746 1.4 FANTOM5 ENCODE dbSUPER 13.3 -125.5 -125543 3.7 PKNOX1 ATF1 NFIB ARID4B THRB ZNF48 RARA EGR1 FOS RELB MYLK3 SHCBP1 VPS35 ORC6 GPT2 GC16M046768 GC16P046705
GH16G046865 1.5 Ensembl ENCODE dbSUPER 12.3 -241.7 -241734 1.1 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 SLC30A9 FOS SP5 ZHX2 SHCBP1 MYLK3 ENSG00000261725 GPT2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SHCBP1 on UCSC Golden Path with GeneCards custom track

Promoters for SHCBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085457 1710 1401 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 FOS ZHX2 MXD4 NFYC

Genomic Location for SHCBP1 Gene

Chromosome:
16
Start:
46,580,554 bp from pter
End:
46,622,810 bp from pter
Size:
42,257 bases
Orientation:
Minus strand

Genomic View for SHCBP1 Gene

Genes around SHCBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHCBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHCBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHCBP1 Gene

Proteins for SHCBP1 Gene

  • Protein details for SHCBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEM2-SHCBP_HUMAN
    Recommended name:
    SHC SH2 domain-binding protein 1
    Protein Accession:
    Q8NEM2
    Secondary Accessions:
    • Q96N60
    • Q9BVS0
    • Q9H6P6

    Protein attributes for SHCBP1 Gene

    Size:
    672 amino acids
    Molecular mass:
    75690 Da
    Quaternary structure:
    • Interacts directly with isoform p52shc of SHC1 via its SH2 domain (By similarity). Interacts with TRIM71; leading to enhanced SHCBP1 protein stability (By similarity). Interacts with both members of the centralspindlin complex, KIF23 and RACGAP1 (PubMed:21187330).
    SequenceCaution:
    • Sequence=BAB15208.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for SHCBP1 Gene

Post-translational modifications for SHCBP1 Gene

  • Ubiquitination at isoforms=296, Lys300, Lys315, and Lys517
  • Modification sites at PhosphoSitePlus

Other Protein References for SHCBP1 Gene

No data available for DME Specific Peptides for SHCBP1 Gene

Domains & Families for SHCBP1 Gene

Protein Domains for SHCBP1 Gene

Suggested Antigen Peptide Sequences for SHCBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SHCBP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SHCBP1 Gene

Function for SHCBP1 Gene

Molecular function for SHCBP1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.

Gene Ontology (GO) - Molecular Function for SHCBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25852190
GO:0042169 SH2 domain binding IEA --
genes like me logo Genes that share ontologies with SHCBP1: view
genes like me logo Genes that share phenotypes with SHCBP1: view

Animal Models for SHCBP1 Gene

MGI Knock Outs for SHCBP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SHCBP1 Gene

Localization for SHCBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHCBP1 Gene

Midbody. Cytoplasm, cytoskeleton, spindle. Note=Displays weak localization to the spindle midzone in some early telophase cells and is concentrated at the midbody in late cytokinesis. {ECO:0000269 PubMed:21187330}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SHCBP1 gene
Compartment Confidence
cytoskeleton 4
cytosol 2
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SHCBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IEA --
GO:0005856 cytoskeleton IEA --
GO:0030496 midbody IEA --
genes like me logo Genes that share ontologies with SHCBP1: view

Pathways & Interactions for SHCBP1 Gene

genes like me logo Genes that share pathways with SHCBP1: view

Pathways by source for SHCBP1 Gene

2 Sino Biological pathways for SHCBP1 Gene

Gene Ontology (GO) - Biological Process for SHCBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008543 fibroblast growth factor receptor signaling pathway IEA,ISS --
GO:2000177 regulation of neural precursor cell proliferation ISS,IEA --
genes like me logo Genes that share ontologies with SHCBP1: view

No data available for SIGNOR curated interactions for SHCBP1 Gene

Transcripts for SHCBP1 Gene

Unigene Clusters for SHCBP1 Gene

SHC SH2-domain binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHCBP1 Gene

No ASD Table

Relevant External Links for SHCBP1 Gene

GeneLoc Exon Structure for
SHCBP1
ECgene alternative splicing isoforms for
SHCBP1

Expression for SHCBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SHCBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SHCBP1 Gene

This gene is overexpressed in Testis (55.9) and Fetal ovary (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SHCBP1 Gene



Protein tissue co-expression partners for SHCBP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SHCBP1 Gene:

SHCBP1

SOURCE GeneReport for Unigene cluster for SHCBP1 Gene:

Hs.123253
genes like me logo Genes that share expression patterns with SHCBP1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SHCBP1 Gene

Orthologs for SHCBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SHCBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SHCBP1 34 35
  • 99.7 (n)
cow
(Bos Taurus)
Mammalia SHCBP1 34 35
  • 90.17 (n)
dog
(Canis familiaris)
Mammalia SHCBP1 34 35
  • 89.64 (n)
mouse
(Mus musculus)
Mammalia Shcbp1 34 16 35
  • 82.88 (n)
rat
(Rattus norvegicus)
Mammalia Shcbp1 34
  • 82.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 77 (a)
OneToMany
-- 35
  • 76 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SHCBP1 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves SHCBP1 34 35
  • 73.76 (n)
lizard
(Anolis carolinensis)
Reptilia SHCBP1 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia shcbp1 34
  • 67.24 (n)
Str.10946 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.13015 34
zebrafish
(Danio rerio)
Actinopterygii shcbp1 34 35
  • 60.95 (n)
wufi22a03 34
fruit fly
(Drosophila melanogaster)
Insecta nesd 35
  • 18 (a)
OneToMany
Species where no ortholog for SHCBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHCBP1 Gene

ENSEMBL:
Gene Tree for SHCBP1 (if available)
TreeFam:
Gene Tree for SHCBP1 (if available)

Paralogs for SHCBP1 Gene

Paralogs for SHCBP1 Gene

Pseudogenes.org Pseudogenes for SHCBP1 Gene

genes like me logo Genes that share paralogs with SHCBP1: view

Variants for SHCBP1 Gene

Sequence variations from dbSNP and Humsavar for SHCBP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000116543 -- 46,605,449(+) CTGGT(A/G)TGATG intron-variant
rs1000370858 -- 46,581,649(+) ATACA(G/T)CAAAC nc-transcript-variant, utr-variant-3-prime
rs1000450670 -- 46,620,492(+) AAAAC(-/TTTAT)TTCAC intron-variant
rs1000458374 -- 46,597,864(+) AATAC(G/T)CTAAA intron-variant, utr-variant-3-prime
rs1000523914 -- 46,598,281(+) TGGTA(G/T)AGCCT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SHCBP1 Gene

Variant ID Type Subtype PubMed ID
dgv2975n100 CNV gain 25217958
esv3571142 CNV gain 25503493
esv3571153 CNV gain 25503493
esv3638533 CNV gain 21293372
esv3638534 CNV gain 21293372
nsv1056162 CNV gain 25217958
nsv1066115 CNV gain 25217958
nsv428327 CNV gain 18775914
nsv526656 CNV gain 19592680
nsv833216 CNV loss 17160897

Variation tolerance for SHCBP1 Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.39; 27.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SHCBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SHCBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHCBP1 Gene

Disorders for SHCBP1 Gene

Relevant External Links for SHCBP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SHCBP1

No disorders were found for SHCBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHCBP1 Gene

Publications for SHCBP1 Gene

  1. SHCBP1 is required for midbody organization and cytokinesis completion. (PMID: 25486361) Asano E. … Senga T. (Cell Cycle 2014) 2 3 64
  2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells. (PMID: 10086341) Schmandt R. … McGlade C.J. (Oncogene 1999) 2 3 64

Products for SHCBP1 Gene

Sources for SHCBP1 Gene

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