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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SHCBP1 Gene

protein-coding GIFtS: 48
GCID: GC16M046614

SHC SH2-domain binding protein 1

Explore 1 disease affiliated with
SHCBP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
SHC SH2-Domain Binding Protein 1¹ ²
PAL² ⁵
FLJ22009¹
SHC SH2 Domain-Binding Protein 1²

External Ids:	HGNC: 29547¹	Entrez Gene: 79801²	Ensembl: ENSG00000171241⁷	OMIM: 611027⁵	UniProtKB: Q8NEM2³

Export aliases for SHCBP1 gene to outside databases

Previous GC identifers: GC16M037025 GC16M046555 GC16M046354 GC16M046395 GC16M045171 GC16M032503

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SHCBP_HUMAN, Q8NEM2

Function: May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May

be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural

progenitor cells (By similarity)

Gene Wiki entry for SHCBP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SHCBP1 gene promoter:
Pax-5 AML1a Nkx5-1 NF-kappaB FOXL1 POU2F1 POU2F1a FOXO1a NF-kappaB1 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SHCBP1 promoter sequence

Search SABiosciences Chromatin IP Primers for SHCBP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHCBP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q11.2 Ensembl cytogenetic band: 16q11.2 HGNC cytogenetic band: 16q11

SHCBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHCBP1 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M046614: view genomic region (about GC identifiers)

Start:	46,614,466 bp from pter	End:	46,655,538 bp from pter
Size:	41,073 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SHCBP_HUMAN, Q8NEM2 (See protein sequence)

Recommended Name: SHC SH2 domain-binding protein 1

Size: 672 amino acids; 75690 Da

Subunit: Interacts directly with isoform p52shc of SHC1 via its SH2 domain. Interacts with TRIM71; leading to enhance

SHCBP1 protein stability (By similarity)

Sequence caution: Sequence=BAB15208.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: Q96N60 Q9BVS0 Q9H6P6

Explore the universe of human proteins at neXtProt for SHCBP1: NX_Q8NEM2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NEM2

SHCBP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_079021.3

ENSEMBL proteins:

ENSP00000306473 ENSP00000460840

Human Recombinant Protein Products:

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	Uscn Proteins for SHCBP1

SHCBP1 Antibody Products:

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	ThermoFisher Antibody for SHCBP1

Assay Products for SHCBP1:

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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SHCBP1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SHCBP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SHCBP1 for domains About GeneDecksing

3 InterPro domains/families:

IPR012334 Pectin_lyas_fold

IPR011050 Pectin_lyase_fold/virulence

IPR006626 PbH1

Graphical View of Domain Structure for InterPro Entry Q8NEM2

ProtoNet protein and cluster: Q8NEM2

1 Blocks protein family: IPB006626 Parallel beta-helix repeat

UniProtKB/Swiss-Prot: SHCBP_HUMAN, Q8NEM2

Similarity: Contains 5 PbH1 repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SHCBP_HUMAN, Q8NEM2

Function: May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May

be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural

progenitor cells (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: SHCBP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SHCBP1
		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate SHCBP1 (see all 24):
		hsa-miR-4291 hsa-miR-302d hsa-miR-520e hsa-miR-302e hsa-miR-515-5p hsa-miR-520a-3p hsa-miR-372 hsa-miR-3658

		SwitchGear 3'UTR luciferase reporter plasmid: SHCBP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SHCBP1 (see all 4) OriGene shRNA RFP: SHCBP1 OriGene siRNA: SHCBP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SHCBP1

Gene Editing
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DNA2.0 Custom Protein Engineering Service for SHCBP1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SHCBP1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SHCBP1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SHCBP1 (NM_024745)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SHCBP1
		Search LifeMap BioReagents cell lines for SHCBP1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHCBP1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--
GO:0042169	SH2 domain binding	IEA	--

SHCBP1 for ontologies About GeneDecksing

Animal Models:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Shcbp1):

no phenotypic analysis

SHCBP1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SHCBP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/11 Interacting proteins for SHCBP1 (Q8NEM2^{2, 3} ENSP00000306473⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ZUFSP	Q96AP4²^,³, ENSP00000357565⁴	MINT-66550 I2D: score=3 STRING: ENSP00000357565
SFN	P31947²^,³	MINT-3975636 I2D: score=2
YWHAG	P61981²^,³, ENSP00000306330⁴	MINT-50847 I2D: score=3 STRING: ENSP00000306330
SHC1	P29353³, ENSP00000401303⁴	I2D: score=5 STRING: ENSP00000401303
USP49	Q70CQ1³, ENSP00000297229⁴	I2D: score=2 STRING: ENSP00000297229

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008543	fibroblast growth factor receptor signaling pathway	ISS	--
GO:2000177	regulation of neural precursor cell proliferation	ISS	--

SHCBP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SHCBP1
Search CenterWatch for drugs/clinical trials and news about SHCBP1 / SHCBP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SHCBP1 gene:

NM_024745.4

Unigene Cluster for SHCBP1:

SHC SH2-domain binding protein 1

Hs.123253 [show with all ESTs]

Unigene Representative Sequence: NM_024745

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000303383(uc002eec.4) ENST00000567698 ENST00000563219 ENST00000569702

ENST00000566016 ENST00000565887 ENST00000564272

miRNA Products:		OriGene 3'-UTR Clone: SHCBP1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SHCBP1
		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate SHCBP1 (see all 24):
		hsa-miR-4291 hsa-miR-302d hsa-miR-520e hsa-miR-302e hsa-miR-515-5p hsa-miR-520a-3p hsa-miR-372 hsa-miR-3658

		SwitchGear 3'UTR luciferase reporter plasmid: SHCBP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SHCBP1 (see all 4) OriGene shRNA RFP: SHCBP1 OriGene siRNA: SHCBP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SHCBP1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SHCBP1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SHCBP1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SHCBP1 (NM_024745)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SHCBP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHCBP1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SHCBP1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SHCBP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SHCBP1

Additional cDNA sequence:

AK025662.1 AK055931.1 AK225315.1 AK292164.1 AK310430.1 AK315706.1 BC000960.1 BC030699.1

5 DOTS entries:

DT.311131 DT.102823095 DT.100701561 DT.91801056 DT.101966797

24/62 AceView cDNA sequences (see all 62):

AA401234 BX103548 AA346154 AA346159 CA421392 BC000960 BF516062 BG388411

AA346160 CA426517 CB145723 BM918666 NM_024745 BI334244 AL710757 BI495145

AK055931 BI495127 CA445582 BE464176 AK025662 CK128665 BI861779 BU623290

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SHCBP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGTTCCAGC

About this image

SHCBP1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Epicardium

Kidney Endothelial Cells

Endothelium

Brain

Brain

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Adult human kidney epithelial cells (Primary Cell)

Kidney

See SHCBP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SHCBP1

SOURCE GeneReport for Unigene cluster: Hs.123253

SABiosciences Custom PCR Arrays for SHCBP1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SHCBP1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SHCBP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SHCBP1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHCBP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SHCBP1 gene from 6/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Shcbp1^{1 , 5}	Shc SH2-domain binding protein 1^{1, 5}	82.88(n)¹ 78.29(a)¹		8 (2.09 cM)⁵ 20419¹ NM_011369.2¹ NP_035499.1¹ 4735980⁵
chicken (Gallus gallus)	Aves	SHCBP1¹	SHC SH2-domain binding protein 1	73.76(n) 75.24(a)		415751 XM_003641935.1 XP_003641983.1
lizard (Anolis carolinensis)	Reptilia	SHCBP1⁶	--	68(a)	1 ↔ 1	LGc(3735178-3773516)
African clawed frog (Xenopus laevis)	Amphibia	Xl.13015²	Xenopus laevis transcribed sequence with weak similarity more	75.23(n)		BU913535.1
zebrafish (Danio rerio)	Actinopterygii	wufi22a03²	wufi22a03	74.34(n)		333933 BC057538.1
fruit fly (Drosophila melanogaster)	Insecta	nesd¹	nessun dorma	40.63(n) 25.37(a)		35298 NM_136181.1 NP_610025.1

ENSEMBL Gene Tree for SHCBP1 (if available)
TreeFam Gene Tree for SHCBP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SHCBP1 gene

SHCBP1L²

SHCBP1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for SHCBP1
PGOHUM00000234277

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs148725754^1,2		--	46613973(+)	`TGGAGA/GTTACA`	1	--	int¹		0	--	--	--	--
rs199591996^1,2		--	46614116(+)	`AAATT-/AAAAAA`	1	--	int¹		0	--	--	--	--
rs187394389^1,2		--	46614402(+)	`TAAATG/TACCAC`	1	--	int¹		0	--	--	--	--
rs114722965^1,2	F,	--	46614478(+)	`ATTTCA/CTCACT`	1	--	ut3¹		1		WA	118
rs12928618^1,2	C,F,H,	--	46614595(+)	`TTGTAC/TAGTTA`	1	--	ut3¹		12		NS EA NA	1376
rs192377280^1,2		--	46615022(+)	`CAACAC/TTGGCT`	1	--	ut3¹		0	--	--	--	--
rs142690638^1,2		--	46615039(+)	`AACACA/GTTTCA`	1	--	ut3¹		0	--	--	--	--
rs150998534^1,2		--	46615076(+)	`CTATCA/GCTGTT`	1	--	ut3¹		0	--	--	--	--
rs11863327^1,2	C,F,H,	--	46615096(+)	`GCATAG/CCTCAA`	1	--	ut3¹		6		NS EA NA WA	538
rs183780120^1,2		--	46615124(+)	`TTGACC/GTCTCA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SHCBP1 (46614466 - 46655538 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SHCBP1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SHCBP1

DNA2.0 Custom Variant and Variant Library Synthesis for SHCBP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SHCBP1 for disorders           About GeneDecksing

OMIM gene information: 611027    OMIM disorders: --

1 disease for SHCBP1:    About MalaCards

cervicitis

Export disorders for SHCBP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SHCBP1 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with SHCBP1)

Utopia: connect your pdf to the dynamic
world of online information

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells. (PubMed id 10086341)^{1, 3} Schmandt R....McGlade C.J. (1999)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 79801	HGNC: 29547	AceView: SHCBP1	Ensembl:ENSG00000171241	euGenes: HUgn79801
ECgene: SHCBP1	H-InvDB: SHCBP1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SHCBP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SHCBP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SHCBP1 gene:
Search GeneIP for patents involving SHCBP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	Browse OriGene Antibodies		OriGene shRNA RFP for SHCBP1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SHCBP1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SHCBP1
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	Regulatory tfbs in SHCBP1 promoter
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHCBP1

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ThermoFisher Antibody for SHCBP1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHCBP1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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SHCBP1 Gene

SHC SH2-domain binding protein 1

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SHCBP1 Gene

SHC SH2-domain binding protein 1

Aliasesfor SHCBP1 gene

Summariesfor SHCBP1 gene

Genomic Viewsfor SHCBP1 gene

Proteinsfor SHCBP1 gene

Protein Domains /Familiesfor SHCBP1 gene

Functionfor SHCBP1 gene

Pathways & Interactionsfor SHCBP1 gene

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Expression for SHCBP1 gene

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Genome Databases showing SHCBP1 gene

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Aliases
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Summaries
for SHCBP1 gene

Genomic Views
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for SHCBP1 gene

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for SHCBP1 gene

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for SHCBP1 gene

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for SHCBP1 gene

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for SHCBP1 gene

Expression
for SHCBP1 gene

Orthologs
for SHCBP1 gene

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for SHCBP1 gene

Genomic Variants
for SHCBP1 gene

Disorders / Diseases
for SHCBP1 gene

Publications
for SHCBP1 gene

Intellectual Property
for SHCBP1 gene

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for SHCBP1 gene