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Aliases for SHCBP1 Gene

Aliases for SHCBP1 Gene

  • SHC Binding And Spindle Associated 1 2 3
  • SHC SH2-Domain Binding Protein 1 2 3 5
  • Protein Expressed In Activated Lymphocytes 2 3
  • PAL 3

External Ids for SHCBP1 Gene

Previous GeneCards Identifiers for SHCBP1 Gene

  • GC16M037025
  • GC16M046555
  • GC16M046354
  • GC16M046395
  • GC16M045171
  • GC16M032503

Summaries for SHCBP1 Gene

GeneCards Summary for SHCBP1 Gene

SHCBP1 (SHC Binding And Spindle Associated 1) is a Protein Coding gene. GO annotations related to this gene include SH2 domain binding. An important paralog of this gene is SHCBP1L.

UniProtKB/Swiss-Prot for SHCBP1 Gene

  • May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells (By similarity).

Gene Wiki entry for SHCBP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHCBP1 Gene

Genomics for SHCBP1 Gene

Regulatory Elements for SHCBP1 Gene

Enhancers for SHCBP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SHCBP1 on UCSC Golden Path with GeneCards custom track

Promoters for SHCBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SHCBP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SHCBP1 Gene

Chromosome:
16
Start:
46,580,554 bp from pter
End:
46,622,810 bp from pter
Size:
42,257 bases
Orientation:
Minus strand

Genomic View for SHCBP1 Gene

Genes around SHCBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHCBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHCBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHCBP1 Gene

Proteins for SHCBP1 Gene

  • Protein details for SHCBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEM2-SHCBP_HUMAN
    Recommended name:
    SHC SH2 domain-binding protein 1
    Protein Accession:
    Q8NEM2
    Secondary Accessions:
    • Q96N60
    • Q9BVS0
    • Q9H6P6

    Protein attributes for SHCBP1 Gene

    Size:
    672 amino acids
    Molecular mass:
    75690 Da
    Quaternary structure:
    • Interacts directly with isoform p52shc of SHC1 via its SH2 domain. Interacts with TRIM71; leading to enhance SHCBP1 protein stability (By similarity).
    SequenceCaution:
    • Sequence=BAB15208.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for SHCBP1 Gene

Proteomics data for SHCBP1 Gene at MOPED

Post-translational modifications for SHCBP1 Gene

  • Ubiquitination at Lys 296, Lys 300, Lys 315, and Lys 517
  • Modification sites at PhosphoSitePlus

Other Protein References for SHCBP1 Gene

Antibody Products

No data available for DME Specific Peptides for SHCBP1 Gene

Domains & Families for SHCBP1 Gene

Protein Domains for SHCBP1 Gene

Suggested Antigen Peptide Sequences for SHCBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NEM2

UniProtKB/Swiss-Prot:

SHCBP_HUMAN :
  • Contains 5 PbH1 repeats.
Similarity:
  • Contains 5 PbH1 repeats.
genes like me logo Genes that share domains with SHCBP1: view

No data available for Gene Families for SHCBP1 Gene

Function for SHCBP1 Gene

Molecular function for SHCBP1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells (By similarity).
genes like me logo Genes that share phenotypes with SHCBP1: view

Animal Models for SHCBP1 Gene

MGI Knock Outs for SHCBP1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SHCBP1 Gene

Localization for SHCBP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SHCBP1 Gene COMPARTMENTS Subcellular localization image for SHCBP1 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SHCBP1 Gene

Pathways & Interactions for SHCBP1 Gene

SuperPathways for SHCBP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SHCBP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SHCBP1 Gene

Drugs & Compounds for SHCBP1 Gene

No Compound Related Data Available

Transcripts for SHCBP1 Gene

Unigene Clusters for SHCBP1 Gene

SHC SH2-domain binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SHCBP1 Gene

No ASD Table

Relevant External Links for SHCBP1 Gene

GeneLoc Exon Structure for
SHCBP1
ECgene alternative splicing isoforms for
SHCBP1

Expression for SHCBP1 Gene

mRNA expression in normal human tissues for SHCBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SHCBP1 Gene

This gene is overexpressed in Testis (55.9) and Fetal ovary (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SHCBP1 Gene



SOURCE GeneReport for Unigene cluster for SHCBP1 Gene Hs.123253

genes like me logo Genes that share expression patterns with SHCBP1: view

Protein tissue co-expression partners for SHCBP1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SHCBP1 Gene

Orthologs for SHCBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SHCBP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SHCBP1 35
  • 90.17 (n)
  • 90.32 (a)
SHCBP1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SHCBP1 35
  • 89.64 (n)
  • 89.04 (a)
SHCBP1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Shcbp1 35
  • 82.88 (n)
  • 78.29 (a)
Shcbp1 16
Shcbp1 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SHCBP1 35
  • 99.7 (n)
  • 99.4 (a)
SHCBP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Shcbp1 35
  • 82.78 (n)
  • 78.29 (a)
oppossum
(Monodelphis domestica)
Mammalia SHCBP1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
chicken
(Gallus gallus)
Aves SHCBP1 35
  • 73.76 (n)
  • 75.24 (a)
SHCBP1 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SHCBP1 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia shcbp1 35
  • 67.24 (n)
  • 63.85 (a)
Str.10946 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.13015 35
zebrafish
(Danio rerio)
Actinopterygii shcbp1 35
  • 60.95 (n)
  • 57.93 (a)
wufi22a03 35
shcbp1 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta nesd 36
  • 18 (a)
OneToMany
Species with no ortholog for SHCBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHCBP1 Gene

ENSEMBL:
Gene Tree for SHCBP1 (if available)
TreeFam:
Gene Tree for SHCBP1 (if available)

Paralogs for SHCBP1 Gene

Paralogs for SHCBP1 Gene

Pseudogenes.org Pseudogenes for SHCBP1 Gene

genes like me logo Genes that share paralogs with SHCBP1: view

Variants for SHCBP1 Gene

Sequence variations from dbSNP and Humsavar for SHCBP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs6598679 - 46,621,298(+) AGCCC(A/G/T)TGCGC reference, missense
rs11545690 - 46,618,297(-) TTTTA(G/T)GCCAG reference, missense
rs8063581 -- 46,588,171(+) agcag(C/T)gtgta intron-variant
rs8182194 -- 46,612,755(+) GGCTC(C/T)AATAT intron-variant
rs9673514 -- 46,588,905(+) aacat(C/T)gatgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SHCBP1 Gene

Variant ID Type Subtype PubMed ID
nsv833216 CNV Loss 17160897
nsv526656 CNV Gain 19592680
nsv428327 CNV Gain 18775914

Variation tolerance for SHCBP1 Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.39; 27.47% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SHCBP1 Gene

Disorders for SHCBP1 Gene

Relevant External Links for SHCBP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SHCBP1

No disorders were found for SHCBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHCBP1 Gene

Publications for SHCBP1 Gene

  1. SHCBP1 is required for midbody organization and cytokinesis completion. (PMID: 25486361) Asano E. … Senga T. (Cell Cycle 2014) 2 3 67
  2. Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells. (PMID: 10086341) Schmandt R. … McGlade C.J. (Oncogene 1999) 2 3
  3. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for SHCBP1 Gene

Sources for SHCBP1 Gene

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