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Aliases for SHC4 Gene

Aliases for SHC4 Gene

  • SHC (Src Homology 2 Domain Containing) Family, Member 4 2 3
  • Rai-Like Protein 2 3 4
  • Src Homology 2 Domain-Containing-Transforming Protein C4 3 4
  • SHC-Transforming Protein D 3 4
  • SH2 Domain Protein C4 3 4
  • HShcD 3 4
  • RaLP 3 4
  • SHCD 3 4
  • SHC-Transforming Protein 4 3

External Ids for SHC4 Gene

Previous GeneCards Identifiers for SHC4 Gene

  • GC15M046904
  • GC15M049115
  • GC15M025948

Summaries for SHC4 Gene

GeneCards Summary for SHC4 Gene

SHC4 (SHC (Src Homology 2 Domain Containing) Family, Member 4) is a Protein Coding gene. Diseases associated with SHC4 include urethral stricture. Among its related pathways are Ras signaling pathway and MicroRNAs in cancer. GO annotations related to this gene include protein domain specific binding and receptor tyrosine kinase binding. An important paralog of this gene is SHC1.

UniProtKB/Swiss-Prot for SHC4 Gene

  • Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHC4 Gene

Genomics for SHC4 Gene

Regulatory Elements for SHC4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SHC4 Gene

48,823,735 bp from pter
48,963,507 bp from pter
139,773 bases
Minus strand

Genomic View for SHC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SHC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHC4 Gene

Proteins for SHC4 Gene

  • Protein details for SHC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SHC-transforming protein 4
    Protein Accession:
    Secondary Accessions:
    • Q6UXQ3
    • Q8IYW3

    Protein attributes for SHC4 Gene

    630 amino acids
    Molecular mass:
    68785 Da
    Quaternary structure:
    • Interacts (via PID domain) with phosphorylated MUSK (via NPXY motif); undergoes tyrosine phosphorylation downstream of activated MUSK. Interacts with GRB2; the interaction is dependent of Tyr-424 phosphorylation and increased by EGF.

    Alternative splice isoforms for SHC4 Gene


neXtProt entry for SHC4 Gene

Proteomics data for SHC4 Gene at MOPED

Post-translational modifications for SHC4 Gene

  • Phosphorylated; the phosphorylation is enhanced by EGF. Phosphorylation at Tyr-424 is required for the interaction with GRB2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SHC4 Gene

No data available for DME Specific Peptides for SHC4 Gene

Domains for SHC4 Gene

Gene Families for SHC4 Gene

  • SH2D :SH2 domain containing

Suggested Antigen Peptide Sequences for SHC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6S5L8
  • Contains 1 PID domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SHC4: view

Function for SHC4 Gene

Molecular function for SHC4 Gene

UniProtKB/Swiss-Prot Function: Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.

Gene Ontology (GO) - Molecular Function for SHC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24658140
GO:0019901 protein kinase binding IBA --
GO:0019904 protein domain specific binding IEA --
GO:0030971 receptor tyrosine kinase binding IBA --
genes like me logo Genes that share ontologies with SHC4: view

Phenotypes for SHC4 Gene

genes like me logo Genes that share phenotypes with SHC4: view

Animal Model Products

CRISPR Products

miRNA for SHC4 Gene

miRTarBase miRNAs that target SHC4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SHC4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SHC4 Gene

Localization for SHC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHC4 Gene

Cell junction, synapse, postsynaptic cell membrane. Note=Colocalized with MUSK at the neuromuscular junction. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for SHC4 Gene COMPARTMENTS Subcellular localization image for SHC4 gene
Compartment Confidence
cytosol 3
extracellular 3
plasma membrane 3
nucleus 1

Gene Ontology (GO) - Cellular Components for SHC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0030054 cell junction IEA --
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with SHC4: view

Pathways for SHC4 Gene

genes like me logo Genes that share pathways with SHC4: view

Pathways by source for SHC4 Gene

Gene Ontology (GO) - Biological Process for SHC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0010468 regulation of gene expression IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with SHC4: view

Transcripts for SHC4 Gene

Unigene Clusters for SHC4 Gene

SHC (Src homology 2 domain containing) family, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SHC4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SHC4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHC4 Gene

No ASD Table

Relevant External Links for SHC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SHC4 Gene

mRNA expression in normal human tissues for SHC4 Gene

mRNA differential expression in normal tissues according to GTEx for SHC4 Gene

This gene is overexpressed in Nerve - Tibial (8.4) and Artery - Coronary (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SHC4 Gene

SOURCE GeneReport for Unigene cluster for SHC4 Gene Hs.642615

mRNA Expression by UniProt/SwissProt for SHC4 Gene

Tissue specificity: Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential.
genes like me logo Genes that share expressions with SHC4: view

In Situ Assay Products

Orthologs for SHC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SHC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SHC4 35
  • 99.68 (n)
  • 99.37 (a)
SHC4 36
  • 99 (a)
(Bos Taurus)
Mammalia SHC4 35
  • 90.21 (n)
  • 89.68 (a)
SHC4 36
  • 90 (a)
(Canis familiaris)
Mammalia SHC4 35
  • 89.84 (n)
  • 88.41 (a)
SHC4 36
  • 88 (a)
(Mus musculus)
Mammalia Shc4 35
  • 83.6 (n)
  • 80.35 (a)
Shc4 16
Shc4 36
  • 80 (a)
(Monodelphis domestica)
Mammalia SHC4 36
  • 69 (a)
(Rattus norvegicus)
Mammalia Shc4 35
  • 83.01 (n)
  • 80.06 (a)
(Gallus gallus)
Aves SHC4 35
  • 70.24 (n)
  • 68.51 (a)
SHC4 36
  • 67 (a)
(Anolis carolinensis)
Reptilia SHC4 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia shc4 35
  • 62.33 (n)
  • 58.17 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011463 35
  • 54.21 (n)
  • 51.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta Shc 35
  • 53.86 (n)
  • 53.38 (a)
Shc 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea shc-1 36
  • 29 (a)
Species with no ortholog for SHC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SHC4 Gene

Gene Tree for SHC4 (if available)
Gene Tree for SHC4 (if available)

Paralogs for SHC4 Gene

Paralogs for SHC4 Gene

Selected SIMAP similar genes for SHC4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SHC4: view

Variants for SHC4 Gene

Sequence variations from dbSNP and Humsavar for SHC4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs3777 -- 48,825,229(-) ATCTA(G/T)CAGTC utr-variant-3-prime
rs881814 -- 48,925,417(-) TTAGG(C/G)CTTTG intron-variant
rs881815 -- 48,925,409(-) TTGTA(C/T)GTACC intron-variant
rs882824 -- 48,843,695(-) TATAG(A/G)GTGGG intron-variant
rs934740 -- 48,914,600(+) ATGAC(A/G)TGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SHC4 Gene

Variant ID Type Subtype PubMed ID
nsv833001 CNV Gain 17160897
esv270490 CNV Insertion 20981092
esv274434 CNV Insertion 20981092
nsv827330 CNV Loss 20364138

Relevant External Links for SHC4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHC4 Gene

Disorders for SHC4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SHC4 Gene including...

Search for SHC4 Gene in MalaCards »

(2) University of Copenhagen DISEASES for SHC4 Gene

Relevant External Links for SHC4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SHC4: view

No data available for UniProtKB/Swiss-Prot for SHC4 Gene

Publications for SHC4 Gene

  1. Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples. (PMID: 21621269) Aragam N. … Pan Y. (J Affect Disord 2011) 3 48
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. RaLP, a new member of the Src homology and collagen family, regulates cell migration and tumor growth of metastatic melanomas. (PMID: 17409413) Fagiani E. … Lanfrancone L. (Cancer Res. 2007) 3 4
  4. Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase. (PMID: 17452444) Jones N. … Pawson T. (Mol. Cell. Biol. 2007) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for SHC4 Gene

Sources for SHC4 Gene

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