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Aliases for SHC4 Gene

Aliases for SHC4 Gene

  • SHC (Src Homology 2 Domain Containing) Family Member 4 2 3 5
  • Rai-Like Protein 2 3 4
  • Src Homology 2 Domain-Containing-Transforming Protein C4 3 4
  • SHC (Src Homology 2 Domain Containing) Family, Member 4 2 3
  • SHC-Transforming Protein D 3 4
  • SH2 Domain Protein C4 3 4
  • HShcD 3 4
  • RaLP 3 4
  • SHCD 3 4

External Ids for SHC4 Gene

Previous GeneCards Identifiers for SHC4 Gene

  • GC15M046904
  • GC15M049115
  • GC15M025948

Summaries for SHC4 Gene

GeneCards Summary for SHC4 Gene

SHC4 (SHC (Src Homology 2 Domain Containing) Family Member 4) is a Protein Coding gene. Diseases associated with SHC4 include Male Reproductive Organ Cancer. Among its related pathways are Bacterial invasion of epithelial cells and ErbB signaling pathway. GO annotations related to this gene include protein kinase binding and receptor tyrosine kinase binding. An important paralog of this gene is SHC1.

UniProtKB/Swiss-Prot for SHC4 Gene

  • Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHC4 Gene

Genomics for SHC4 Gene

Regulatory Elements for SHC4 Gene

Enhancers for SHC4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SHC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SHC4 Gene

48,823,735 bp from pter
48,963,444 bp from pter
139,710 bases
Minus strand

Genomic View for SHC4 Gene

Genes around SHC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHC4 Gene

Proteins for SHC4 Gene

  • Protein details for SHC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SHC-transforming protein 4
    Protein Accession:
    Secondary Accessions:
    • Q6UXQ3
    • Q8IYW3

    Protein attributes for SHC4 Gene

    630 amino acids
    Molecular mass:
    68785 Da
    Quaternary structure:
    • Interacts (via PID domain) with phosphorylated MUSK (via NPXY motif); undergoes tyrosine phosphorylation downstream of activated MUSK. Interacts with GRB2; the interaction is dependent of Tyr-424 phosphorylation and increased by EGF.

    Alternative splice isoforms for SHC4 Gene


neXtProt entry for SHC4 Gene

Proteomics data for SHC4 Gene at MOPED

Post-translational modifications for SHC4 Gene

  • Phosphorylated; the phosphorylation is enhanced by EGF. Phosphorylation at Tyr-424 is required for the interaction with GRB2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SHC4 Gene

No data available for DME Specific Peptides for SHC4 Gene

Domains & Families for SHC4 Gene

Gene Families for SHC4 Gene

Suggested Antigen Peptide Sequences for SHC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PID domain.
  • Contains 1 PID domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SHC4: view

Function for SHC4 Gene

Molecular function for SHC4 Gene

UniProtKB/Swiss-Prot Function:
Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
genes like me logo Genes that share phenotypes with SHC4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SHC4 Gene

Localization for SHC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHC4 Gene

Cell junction, synapse, postsynaptic cell membrane. Note=Colocalized with MUSK at the neuromuscular junction. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for SHC4 Gene COMPARTMENTS Subcellular localization image for SHC4 gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 3
nucleus 1

Gene Ontology (GO) - Cellular Components for SHC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with SHC4: view

Pathways & Interactions for SHC4 Gene

genes like me logo Genes that share pathways with SHC4: view

Pathways by source for SHC4 Gene

Gene Ontology (GO) - Biological Process for SHC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0048863 stem cell differentiation IEA --
genes like me logo Genes that share ontologies with SHC4: view

No data available for SIGNOR curated interactions for SHC4 Gene

Drugs & Compounds for SHC4 Gene

No Compound Related Data Available

Transcripts for SHC4 Gene

Unigene Clusters for SHC4 Gene

SHC (Src homology 2 domain containing) family, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SHC4 Gene

No ASD Table

Relevant External Links for SHC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SHC4 Gene

mRNA expression in normal human tissues for SHC4 Gene

mRNA differential expression in normal tissues according to GTEx for SHC4 Gene

This gene is overexpressed in Nerve - Tibial (x8.4) and Artery - Coronary (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SHC4 Gene

SOURCE GeneReport for Unigene cluster for SHC4 Gene Hs.642615

mRNA Expression by UniProt/SwissProt for SHC4 Gene

Tissue specificity: Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential.
genes like me logo Genes that share expression patterns with SHC4: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for SHC4 Gene

Orthologs for SHC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SHC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SHC4 35
  • 90.21 (n)
  • 89.68 (a)
SHC4 36
  • 90 (a)
(Canis familiaris)
Mammalia SHC4 35
  • 89.84 (n)
  • 88.41 (a)
SHC4 36
  • 88 (a)
(Mus musculus)
Mammalia Shc4 35
  • 83.6 (n)
  • 80.35 (a)
Shc4 16
Shc4 36
  • 80 (a)
(Pan troglodytes)
Mammalia SHC4 35
  • 99.68 (n)
  • 99.37 (a)
SHC4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Shc4 35
  • 83.01 (n)
  • 80.06 (a)
(Monodelphis domestica)
Mammalia SHC4 36
  • 69 (a)
(Gallus gallus)
Aves SHC4 35
  • 70.24 (n)
  • 68.51 (a)
SHC4 36
  • 67 (a)
(Anolis carolinensis)
Reptilia SHC4 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia shc4 35
  • 62.33 (n)
  • 58.17 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011463 35
  • 54.21 (n)
  • 51.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta Shc 35
  • 53.86 (n)
  • 53.38 (a)
Shc 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea shc-1 36
  • 29 (a)
Species with no ortholog for SHC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SHC4 Gene

Gene Tree for SHC4 (if available)
Gene Tree for SHC4 (if available)

Paralogs for SHC4 Gene

Paralogs for SHC4 Gene

(4) SIMAP similar genes for SHC4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SHC4: view

Variants for SHC4 Gene

Sequence variations from dbSNP and Humsavar for SHC4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs17856991 - 48,962,862(+) CTTGT(C/T)CCCGA reference, missense
rs17856990 - 48,884,358(+) GAACT(C/T)AACTG reference, missense
rs16961728 - 48,855,995(+) GCCAT(G/T)TGTTC reference, missense
rs17856992 - 48,843,552(+) AGGTA(C/T)CTCGC reference, missense
rs3777 -- 48,825,229(-) ATCTA(G/T)CAGTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SHC4 Gene

Variant ID Type Subtype PubMed ID
nsv833001 CNV Gain 17160897
esv270490 CNV Insertion 20981092
esv274434 CNV Insertion 20981092
nsv827330 CNV Loss 20364138

Variation tolerance for SHC4 Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.45% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SHC4 Gene

Disorders for SHC4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SHC4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
male reproductive organ cancer
  • male genital cancer
- elite association - COSMIC cancer census association via MalaCards
Search SHC4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SHC4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SHC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SHC4 Gene

Publications for SHC4 Gene

  1. Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples. (PMID: 21621269) Aragam N. … Pan Y. (J Affect Disord 2011) 3 48 67
  2. In silico prediction of physical protein interactions and characterization of interactome orphans. (PMID: 25402006) Kotlyar M. … Jurisica I. (Nat. Methods 2015) 3
  3. A nuclear export signal and oxidative stress regulate ShcD subcellular localisation: a potential role for ShcD in the nucleus. (PMID: 24036217) Ahmed S.B. … Prigent S.A. (Cell. Signal. 2014) 3
  4. The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor. (PMID: 24430869) Wills M.K. … Jones N. (Mol. Biol. Cell 2014) 3
  5. The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. (PMID: 24658140) Petschnigg J. … Stagljar I. (Nat. Methods 2014) 3

Products for SHC4 Gene

Sources for SHC4 Gene