Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SHC4 Gene

protein-coding   GIFtS: 55
GCID: GC15M049115

SHC (Src Homology 2 Domain Containing) Family, Member 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SHC (Src Homology 2 Domain Containing) Family, Member 41 2     hShcD2 3
Rai-Like Protein1 2 3     SH2 Domain Protein C42 3
Src Homology 2 Domain-Containing-Transforming Protein C42 3     SHC-Transforming Protein D2 3
RaLP2 3     SHC-Transforming Protein 42
SHCD2 3     

External Ids:    HGNC: 167431   Entrez Gene: 3996942   Ensembl: ENSG000001856347   UniProtKB: Q6S5L83   

Export aliases for SHC4 gene to outside databases

Previous GC identifers: GC15M046904 GC15M025948


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SHC4 Gene: 
SHC4 (SHC (Src homology 2 domain containing) family, member 4) is a protein-coding gene. Diseases associated with SHC4 include urethral stricture, and vestibular nystagmus, and among its related super-pathways are Focal Adhesion and ErbB signaling pathway. GO annotations related to this gene include receptor tyrosine kinase binding and protein domain specific binding. An important paralog of this gene is SHC1.

UniProtKB/Swiss-Prot: SHC4_HUMAN, Q6S5L8
Function: Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the
early phases of agrin-induced tyrosine phosphorylation of CHRNB1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SHC4 gene promoter:
         HOXA9   HOXA9B   RP58   Bach2   HSF1 (long)   Tal-1beta   Meis-1b   E47   HSF1short   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSHC4 promoter sequence
   Search SABiosciences Chromatin IP Primers for SHC4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.1-q21.2   Ensembl cytogenetic band:  15q21.1   HGNC cytogenetic band: 15q21.1-q21.2

SHC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHC4 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M049115:  view genomic region     (about GC identifiers)

Start:
49,115,932 bp from pter      End:
49,255,641 bp from pter
Size:
139,710 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SHC4_HUMAN, Q6S5L8 (See protein sequence)
Recommended Name: SHC-transforming protein 4  
Size: 630 amino acids; 68785 Da
Subunit: Interacts (via PID domain) with phosphorylated MUSK (via NPXY motif); undergoes tyrosine phosphorylation
downstream of activated MUSK. Interacts with GRB2; the interaction is dependent of Tyr-424 phosphorylation and
increased by EGF
Subcellular location: Cell junction, synapse, postsynaptic cell membrane. Note=Colocalized with MUSK at the
neuromuscular junction (By similarity)
Secondary accessions: Q6UXQ3 Q8IYW3
Alternative splicing: 2 isoforms:  Q6S5L8-1   Q6S5L8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SHC4: NX_Q6S5L8

Explore proteomics data for SHC4 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated; the phosphorylation is enhanced by EGF. Phosphorylation at Tyr-424 is required for the interaction
    with GRB2
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6S5L8

  • SHC4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SHC4 Protein Expression
    REFSEQ proteins: NP_976224.3  
    ENSEMBL proteins: 
     ENSP00000329668   ENSP00000379786   ENSP00000443300   ENSP00000453344   ENSP00000453397  

    Human Recombinant Protein Products for SHC4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SHC4
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SHC4
    GenScript Custom Purified and Recombinant Proteins Services for SHC4
    Novus Biologicals SHC4 Protein
    Novus Biologicals SHC4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SHC4 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0030054cell junction IEA--
    GO:0045211postsynaptic membrane IEA--

    SHC4 for ontologies           About GeneDecksing



    SHC4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SHC4
    OriGene Custom Antibody Services for SHC4
    GenScript Custom Superior Antibodies Services for SHC4
    Novus Biologicals SHC4 Antibodies
    Abcam antibodies for SHC4
    Cloud-Clone Corp. Antibodies for SHC4 
    Search ThermoFisher Antibodies for SHC4
    LSBio Antibodies in human, mouse, rat for SHC4 

    Assay Products for SHC4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SHC4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SHC4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SHC4 
    Cloud-Clone Corp. CLIAs for SHC4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SH2D: SH2 domain containing

    4 InterPro protein domains:
     IPR006020 PTyr_interaction_dom
     IPR006019 PID_domain
     IPR000980 SH2
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q6S5L8

    ProtoNet protein and cluster: Q6S5L8

    2 Blocks protein domains:
    IPB006019 SHC phosphotyrosine interaction domain signature
    IPB006020 Phosphotyrosine interaction domain


    UniProtKB/Swiss-Prot: SHC4_HUMAN, Q6S5L8
    Similarity: Contains 1 PID domain
    Similarity: Contains 1 SH2 domain


    SHC4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SHC4_HUMAN, Q6S5L8
    Function: Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the
    early phases of agrin-induced tyrosine phosphorylation of CHRNB1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0019904protein domain specific binding IEA--
    GO:0030971receptor tyrosine kinase binding IEA--
         
    SHC4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SHC4:
     Decreased TP53 protein express  Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SHC4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SHC4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SHC4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SHC4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SHC4
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate SHC4 (see all 33):
    hsa-miR-142-5p hsa-miR-607 hsa-miR-488 hsa-miR-218 hsa-miR-3167 hsa-miR-124 hsa-miR-489 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidSHC4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SHC4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SHC4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SHC4
    Sirion Biotech Customized adenovirus for overexpression of SHC4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SHC4 (see all 7)
    OriGene ORF clones in mouse, rat for SHC4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SHC4 (NM_203349)
    Sino Biological Human cDNA Clone for SHC4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SHC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHC4
    Sirion Biotech Customized lentivirus for stable overexpression of SHC4 
                         Customized lentivirus expression plasmids for stable overexpression of SHC4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SHC4
    Search LifeMap BioReagents cell lines for SHC4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHC4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SHC4 About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal adhesion0.64
    2ErbB signaling pathway
    ErbB signaling pathway0.52
    3Glioma
    Glioma0.51
    4Chronic myeloid leukemia
    Chronic myeloid leukemia0.42
    5Development HGF signaling pathway
    Neurotrophin signaling pathway0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SHC4
        BDNF signaling pathway



    5/13         Kegg Pathways  (Kegg details for SHC4) (see all 13):
        ErbB signaling pathway
    Chemokine signaling pathway
    Focal adhesion
    Natural killer cell mediated cytotoxicity
    Neurotrophin signaling pathway


    SHC4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SHC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for SHC4 (Q6S5L83 ENSP000003296684) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046263, ENSP000002695714I2D: score=1 STRING: ENSP00000269571
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    MUSKO151463I2D: score=1 
    RETP079493I2D: score=1 
    ABL1ENSP000003614234STRING: ENSP00000361423
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0035556intracellular signal transduction IEA--

    SHC4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SHC4

    Search CenterWatch for drugs/clinical trials and news about SHC4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SHC4 gene: 
    NM_203349.3  

    Unigene Cluster for SHC4:

    SHC (Src homology 2 domain containing) family, member 4
    Hs.642615  [show with all ESTs]
    Unigene Representative Sequence: NM_203349
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332408(uc010uey.1 uc010uez.1 uc001zxb.1) ENST00000396535
    ENST00000537958 ENST00000557797 ENST00000558220 ENST00000559289
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SHC4
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate SHC4 (see all 33):
    hsa-miR-142-5p hsa-miR-607 hsa-miR-488 hsa-miR-218 hsa-miR-3167 hsa-miR-124 hsa-miR-489 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidSHC4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SHC4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SHC4
    Clone
    Products:
         
    OriGene clones in human, mouse for SHC4 (see all 7)
    OriGene ORF clones in mouse, rat for SHC4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SHC4 (NM_203349)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SHC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHC4
    Sirion Biotech Customized lentivirus for stable overexpression of SHC4 
                         Customized lentivirus expression plasmids for stable overexpression of SHC4 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SHC4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SHC4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SHC4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SHC4

    Additional mRNA sequence: 

    AK124916.1 AK125762.1 AK302156.1 AY358250.1 AY464565.1 BC033907.2 

    6 DOTS entries:

    DT.91698338  DT.97796043  DT.452014  DT.310466  DT.40253927  DT.91999549 

    24/64 AceView cDNA sequences (see all 64):

    AI369481 T40374 AY358250 NM_203349 BM673614 AK124916 BQ183927 AI805865 
    AY464565 BU183540 AA629213 AW102644 AI027957 AI381466 BM453272 AI028748 
    BI757080 AA333137 BQ438596 BG723045 AV728473 AA296615 AI631176 BU852316 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SHC4 expression in normal human tissues (normalized intensities)      SHC4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTATTTTAAT
    SHC4 Expression
    About this image


    SHC4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Ovary (Reproductive System)
             Mature Granulosa Cells Antral Follicle
     
     Endothelium (Cardiovascular System)
             Human corneal endothelial cells
     
     Eye (Sensory Organs)
             Human corneal endothelial cells

    See SHC4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SHC4

    SOURCE GeneReport for Unigene cluster: Hs.642615

    UniProtKB/Swiss-Prot: SHC4_HUMAN, Q6S5L8
    Tissue specificity: Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly
    expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when
    tumor cells acquire migratory competence and invasive potential

        SABiosciences Custom PCR Arrays for SHC4
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SHC4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SHC4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SHC4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SHC4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHC4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SHC4 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Shc41 , 5 SHC (Src homology 2 domain containing) family, member more1, 5 83.6(n)1
    80.35(a)1
      2 (61.76 cM)5
    2718491  NM_199022.21  NP_950187.11 
     1256274475 
    chicken
    (Gallus gallus)
    Aves SHC41 SHC (Src homology 2 domain containing) family, member more 69.79(n)
    68.8(a)
      426482  XM_424123.3  XP_424123.3 
    lizard
    (Anolis carolinensis)
    Reptilia SHC46
    Uncharacterized protein
    58(a)
    1 ↔ 1
    GL343506.1(324957-368996)
    fruit fly
    (Drosophila melanogaster)
    Insecta Shc6
    SHC-adaptor protein
    38(a)
    1 → many
    3L(9420110-9421771)
    worm
    (Caenorhabditis elegans)
    Secernentea shc-16
    Protein SHC-1, isoform a
    28(a)
    1 → many
    I(969680-973137)


    ENSEMBL Gene Tree for SHC4 (if available)
    TreeFam Gene Tree for SHC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SHC4 gene
    SHC12  SHC22  SHC32  
    4 SIMAP similar genes for SHC4 using alignment to 4 protein entries:     SHC4_HUMAN (see all proteins):
    SHC1    SHC3    SHC2    PTPN11

    SHC4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2606 SNPs in SHC4 are shown (see all 2606)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs110706541,2
    C,F,A,H--49115575(+) AGAATC/TCCAGC 1 -- ds500121Minor allele frequency- T:0.27NS EA NA WA 2352
    rs753110481,2
    F--49115730(+) ATTCTG/ATTAGC 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs1155319431,2
    F--49115786(+) TCCCTC/TCTGAT 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs747646281,2
    C,F--49115838(+) ATAAAC/TTCACC 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1479861881,2
    --49115862(+) TTTGAC/TTGAGC 1 -- ds50010--------
    rs1877714681,2
    --49115901(+) ATGACA/CGTTTC 1 -- ds50010--------
    rs1928940111,2
    --49115930(+) CATATG/TCTGTC 1 -- ds50010--------
    rs1416146091,2
    --49115973(+) AAAGTC/TGTTTA 1 -- ut310--------
    rs1848042891,2
    --49115974(+) AAGTCA/GTTTAC 1 -- ut310--------
    rs1884710951,2
    --49116084(+) ACTGTA/GTCTGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SHC4 (49115932 - 49255641 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SHC4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv270490CNV Insertion20981092
    esv274434CNV Insertion20981092
    nsv827330CNV Loss20364138
    nsv833001CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SHC4
    DNA2.0 Custom Variant and Variant Library Synthesis for SHC4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    9 diseases for SHC4:    About MalaCards
    urethral stricture    vestibular nystagmus    urethritis    eating disorder
    major depressive disorder    chronic myeloid leukemia    myeloid leukemia    melanoma
    leukemia

    2 diseases from the University of Copenhagen DISEASES database for SHC4:
    Prostate cancer     Urethral stricture

    SHC4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SHC4
    Human Genome Epidemiology (HuGE) Navigator: SHC4 (1 document)

    Export disorders for SHC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SHC4 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with SHC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association analysis of gender difference s in major depressive disorder in the Netherlands NESDA and NTR population-base d samples. (PubMed id 21621269)1, 4 Aragam N....Pan Y. (2011)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. RaLP, a new member of the Src homology and collagen family, regulates cell migration and tumor growth of metastatic melanomas. (PubMed id 17409413)1, 2 Fagiani E.... Lanfrancone L. (2007)
    4. Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase. (PubMed id 17452444)1, 2 Jones N.... Pawson T. (2007)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Genome-wide association analysis of eating disorder-re lated symptoms, behaviors, and personality traits. (PubMed id 22911880)1 Boraska V....Zeggini E. (2012)
    7. ShcD interacts with TrkB via its PTB and SH2 domains and regulates BDNF-induced MAPK activation. (PubMed id 20663410)1 You Y....Peng X. (2010)
    8. [ShcD interacts with TrkC through its PTB and SH2 doma ins]. (PubMed id 20078941)1 You Y.G....Peng X.Z. (2009)
    9. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
    10. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 399694 HGNC: 16743 AceView: RaLP Ensembl:ENSG00000185634 euGenes: HUgn399694
    ECgene: SHC4 Kegg: 399694 H-InvDB: SHC4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SHC4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SHC4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SHC4 gene:
    Search GeneIP for patents involving SHC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SHC4   OriGene RNAi products in human, mouse, rat for SHC4  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SHC4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SHC4  
     OriGene qSTAR qPCR primer pairs in human, mouse for SHC4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SHC4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SHC4   OriGene Custom Protein Services for SHC4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SHC4
     QIAGEN SeqTarget long-range PCR primers for resequencing SHC4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHC4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SHC4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SHC4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SHC4
     GenScript Custom Purified and Recombinant Proteins Services for SHC4 GenScript cDNA clones with any tag delivered in your preferred vector for SHC4
     GenScript Custom Assay Services for SHC4 GenScript Custom Superior Antibodies Services for SHC4
     GenScript Custom overexpressing Cell Line Services for SHC4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SHC4 promoter
     Search Chromatin IP Primers for SHC4
     RT2 qPCR Primer Assay in human, mouse, rat SHC4
     Search GNC Networks for SHC4
     SABiosciences Custom PCR Arrays for SHC4
     Search Tocris compounds for SHC4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for SHC4
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SHC4 antibodies
     SHC4 proteins
     SHC4 lysates
     Antibodies for SHC4
     See all of Abcam's Antibodies, Kits and Proteins for SHC4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SHC4
     Antibodies for SHC4
     ELISAs for SHC4
     CLIAs for SHC4
     Search LifeMap BioReagents cell lines for SHC4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHC4
     SwitchGear 3'UTR luciferase reporter plasmids for SHC4
     SwitchGear Promoter luciferase reporter plasmids for SHC4
     Search ThermoFisher Antibodies for SHC4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHC4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SHC4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SHC4
    Customized:
     lentivirus for stable overexpression of SHC4
     lentivirus expression plasmids for stable overexpression of SHC4
     adenovirus for overexpression of SHC4
     LSBio Antibodies in human, mouse, rat for SHC4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SHC4 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4