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SHC4 Gene

protein-coding   GIFtS: 55
GCID: GC15M049115

SHC (Src Homology 2 Domain Containing) Family, Member 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SHC (Src Homology 2 Domain Containing) Family, Member 41 2     hShcD2 3
Rai-Like Protein1 2 3     SH2 Domain Protein C42 3
Src Homology 2 Domain-Containing-Transforming Protein C42 3     SHC-Transforming Protein D2 3
RaLP2 3     SHC-Transforming Protein 42
SHCD2 3     

External Ids:    HGNC: 167431   Entrez Gene: 3996942   Ensembl: ENSG000001856347   UniProtKB: Q6S5L83   

Export aliases for SHC4 gene to outside databases

Previous GC identifers: GC15M046904 GC15M025948


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SHC4 Gene:
SHC4 (SHC (Src homology 2 domain containing) family, member 4) is a protein-coding gene. Diseases associated with SHC4 include urethral stricture, and vestibular nystagmus. GO annotations related to this gene include receptor tyrosine kinase binding and protein domain specific binding. An important paralog of this gene is SHC1.

UniProtKB/Swiss-Prot: SHC4_HUMAN, Q6S5L8
Function: Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the
early phases of agrin-induced tyrosine phosphorylation of CHRNB1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SHC4 gene promoter:
         HOXA9   HOXA9B   RP58   Bach2   HSF1 (long)   Tal-1beta   Meis-1b   E47   HSF1short   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSHC4 promoter sequence
   Search Chromatin IP Primers for SHC4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SHC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.1-q21.2   Ensembl cytogenetic band:  15q21.1   HGNC cytogenetic band: 15q21.1-q21.2

SHC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHC4 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M049115:  view genomic region     (about GC identifiers)

Start:
49,115,932 bp from pter      End:
49,255,641 bp from pter
Size:
139,710 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SHC4_HUMAN, Q6S5L8 (See protein sequence)
Recommended Name: SHC-transforming protein 4  
Size: 630 amino acids; 68785 Da
Subunit: Interacts (via PID domain) with phosphorylated MUSK (via NPXY motif); undergoes tyrosine phosphorylation
downstream of activated MUSK. Interacts with GRB2; the interaction is dependent of Tyr-424 phosphorylation and
increased by EGF
Secondary accessions: Q6UXQ3 Q8IYW3
Alternative splicing: 2 isoforms:  Q6S5L8-1   Q6S5L8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SHC4: NX_Q6S5L8

Explore proteomics data for SHC4 at MOPED

Post-translational modifications: 

  • Phosphorylated; the phosphorylation is enhanced by EGF. Phosphorylation at Tyr-424 is required for the interaction
    with GRB21
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SHC4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_976224.3  
    ENSEMBL proteins: 
     ENSP00000329668   ENSP00000379786   ENSP00000443300   ENSP00000453344   ENSP00000453397  

    SHC4 Human Recombinant Protein Products:

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    OriGene Custom MassSpec
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    Novus Biologicals SHC4 Protein
    Novus Biologicals SHC4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for SHC4

    SHC4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for SHC4

    SHC4 Assay Products:

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    Cloud-Clone Corp. ELISAs for SHC4
    Cloud-Clone Corp. CLIAs for SHC4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    4 InterPro protein domains:
     IPR011993 PH_like_dom
     IPR006020 PTB/PI_dom
     IPR006019 PID_Shc-like
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q6S5L8

    ProtoNet protein and cluster: Q6S5L8

    2 Blocks protein domains:
    IPB006019 SHC phosphotyrosine interaction domain signature
    IPB006020 Phosphotyrosine interaction domain


    UniProtKB/Swiss-Prot: SHC4_HUMAN, Q6S5L8
    Similarity: Contains 1 PID domain
    Similarity: Contains 1 SH2 domain


    SHC4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SHC4_HUMAN, Q6S5L8
    Function: Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the
    early phases of agrin-induced tyrosine phosphorylation of CHRNB1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0019904protein domain specific binding IEA--
    GO:0030971receptor tyrosine kinase binding IEA--
         
    SHC4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SHC4:
     Decreased TP53 protein express  Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SHC4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SHC4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SHC4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SHC4

    miRNA
    Products:
        
    miRTarBase miRNAs that target SHC4:
    hsa-mir-335-5p (MIRT017379)

    Block miRNA regulation of human, mouse, rat SHC4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SHC4 (see all 33):
    hsa-miR-142-5p hsa-miR-607 hsa-miR-488 hsa-miR-218 hsa-miR-3167 hsa-miR-124 hsa-miR-489 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidSHC4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SHC4
    Predesigned siRNA for gene silencing in human, mouse, rat SHC4

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SHC4 (NM_203349)
    Sino Biological Human cDNA Clone for SHC4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SHC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHC4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SHC4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHC4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SHC4_HUMAN, Q6S5L8: Cell junction, synapse, postsynaptic cell membrane. Note=Colocalized with MUSK at the
    neuromuscular junction (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    extracellular3
    plasma membrane3
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030054cell junction IEA--
    GO:0045211postsynaptic membrane IEA--

    SHC4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SHC4 About   (see all 15)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    2ErbB signaling pathway
    ErbB signaling pathway0.52
    3Glioma
    Glioma0.51
    4Chronic myeloid leukemia
    Chronic myeloid leukemia0.42
    5Ras signaling pathway
    Ras signaling pathway0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SHC4
        BDNF signaling pathway



    Selected Kegg Pathways  (Kegg details for SHC4) (see all 14):
        ErbB signaling pathway
    Ras signaling pathway
    Chemokine signaling pathway
    Focal adhesion
    Natural killer cell mediated cytotoxicity


    SHC4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SHC4
    Interactions:

        Search GeneGlobe Interaction Network for SHC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SHC4 (Q6S5L83 ENSP000003296684) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046263, ENSP000002695714I2D: score=1 STRING: ENSP00000269571
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    MUSKO151463I2D: score=1 
    RETP079493I2D: score=1 
    ABL1ENSP000003614234STRING: ENSP00000361423
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0035556intracellular signal transduction IEA--

    SHC4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SHC4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SHC4 gene: 
    NM_203349.3  

    Unigene Cluster for SHC4:

    SHC (Src homology 2 domain containing) family, member 4
    Hs.642615  [show with all ESTs]
    Unigene Representative Sequence: NM_203349
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332408(uc010uey.1 uc010uez.1 uc001zxb.1) ENST00000396535
    ENST00000537958 ENST00000557797 ENST00000558220 ENST00000559289
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SHC4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SHC4 (see all 33):
    hsa-miR-142-5p hsa-miR-607 hsa-miR-488 hsa-miR-218 hsa-miR-3167 hsa-miR-124 hsa-miR-489 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidSHC4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SHC4
    Predesigned siRNA for gene silencing in human, mouse, rat SHC4
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SHC4 (NM_203349)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SHC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHC4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SHC4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SHC4
      QuantiTect SYBR Green Assays in human, mouse, rat SHC4
      QuantiFast Probe-based Assays in human, mouse, rat SHC4

    Additional mRNA sequence: 

    AK124916.1 AK125762.1 AK302156.1 AY358250.1 AY464565.1 BC033907.2 

    6 DOTS entries:

    DT.91698338  DT.97796043  DT.452014  DT.310466  DT.40253927  DT.91999549 

    Selected AceView cDNA sequences (see all 64):

    NM_203349 AI369481 AY464565 AI805865 BU183540 BM673614 T40374 AA629213 
    AY358250 AK124916 BQ183927 AI028748 AI027957 BU561636 AV728473 AL583563 
    BI757080 BQ438596 AI382937 BQ721911 AV721025 BQ671617 AA296615 BM453272 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SHC4 expression in normal human tissues (normalized intensities)      SHC4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTATTTTAAT
    SHC4 Expression
    About this image


    SHC4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Ovary (Reproductive System)
             Mature Granulosa Cells Antral Follicle
     
     Testis (Reproductive System)
    SHC4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SHC4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.642615

    UniProtKB/Swiss-Prot: SHC4_HUMAN, Q6S5L8
    Tissue specificity: Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly
    expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when
    tumor cells acquire migratory competence and invasive potential

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHC4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SHC4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Shc41 , 5 SHC (Src homology 2 domain containing) family, member more1, 5 83.6(n)1
    80.35(a)1
      2 (61.76 cM)5
    2718491  NM_199022.21  NP_950187.11 
     1256274475 
    chicken
    (Gallus gallus)
    Aves SHC41 SHC (Src homology 2 domain containing) family, member more 70.24(n)
    68.51(a)
      426482  XM_004943806.1  XP_004943863.1 
    lizard
    (Anolis carolinensis)
    Reptilia SHC46
    SHC (Src homology 2 domain containing) family, mem...
    57(a)
    1 ↔ 1
    GL343506.1(324957-368996)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia shc41 SHC (Src homology 2 domain containing) family, member more 62.33(n)
    58.17(a)
      100490718  XM_002936570.2  XP_002936616.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Shc1 SHC-adaptor protein 53.86(n)
    53.38(a)
      44052  NM_079944.3  NP_524683.2 
    worm
    (Caenorhabditis elegans)
    Secernentea shc-16
    Protein SHC-1, isoform a
    29(a)
    1 → many
    I(969680-973137) WBGene00018788


    ENSEMBL Gene Tree for SHC4 (if available)
    TreeFam Gene Tree for SHC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SHC4 gene
    SHC12  SHC22  SHC32  
    4 SIMAP similar genes for SHC4 using alignment to 4 protein entries:     SHC4_HUMAN (see all proteins):
    SHC2    SHC1    SHC3    PTPN11

    SHC4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SHC4 (see all 2606)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs110706541,2
    C,F,A,H--49115575(+) AGAATC/TCCAGC 1 -- ds500121Minor allele frequency- T:0.27NS EA NA WA 2352
    rs753110481,2
    F--49115730(+) ATTCTG/ATTAGC 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs1155319431,2
    F--49115786(+) TCCCTC/TCTGAT 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs747646281,2
    C,F--49115838(+) ATAAAC/TTCACC 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1479861881,2
    --49115862(+) TTTGAC/TTGAGC 1 -- ds50010--------
    rs1877714681,2
    --49115901(+) ATGACA/CGTTTC 1 -- ds50010--------
    rs1928940111,2
    --49115930(+) CATATG/TCTGTC 1 -- ds50010--------
    rs1416146091,2
    --49115973(+) AAAGTC/TGTTTA 1 -- ut310--------
    rs1848042891,2
    --49115974(+) AAGTCA/GTTTAC 1 -- ut310--------
    rs1884710951,2
    --49116084(+) ACTGTA/GTCTGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SHC4 (49115932 - 49255641 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SHC4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv270490CNV Insertion20981092
    esv274434CNV Insertion20981092
    nsv827330CNV Loss20364138
    nsv833001CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SHC4
    DNA2.0 Custom Variant and Variant Library Synthesis for SHC4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    12 diseases for SHC4:    About MalaCards
    urethral stricture    vestibular nystagmus    urethritis    eating disorder
    major depressive disorder    chronic myeloid leukemia    myeloid leukemia    melanoma
    leukemia    prostate cancer    prostatitis    endotheliitis

    2 diseases from the University of Copenhagen DISEASES database for SHC4:
    Prostate cancer     Urethral stricture

    SHC4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SHC4
    Human Genome Epidemiology (HuGE) Navigator: SHC4 (1 document)

    Export disorders for SHC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SHC4 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with SHC4)
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    1. Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples. (PubMed id 21621269)1, 4 Aragam N....Pan Y. (J Affect Disord 2011)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. RaLP, a new member of the Src homology and collagen family, regulates cell migration and tumor growth of metastatic melanomas. (PubMed id 17409413)1, 2 Fagiani E.... Lanfrancone L. (Cancer Res. 2007)
    4. Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase. (PubMed id 17452444)1, 2 Jones N.... Pawson T. (Mol. Cell. Biol. 2007)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Genome-wide association analysis of eating disorder-related symptoms, behaviors, and personality traits. (PubMed id 22911880)1 Boraska V....Zeggini E. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2012)
    8. ShcD interacts with TrkB via its PTB and SH2 domains and regulates BDNF-induced MAPK activation. (PubMed id 20663410)1 You Y....Peng X. (BMB Rep 2010)
    9. [ShcD interacts with TrkC through its PTB and SH2 domains]. (PubMed id 20078941)1 You Y.G....Peng X.Z. (Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2009)
    10. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 399694 HGNC: 16743 AceView: RaLP Ensembl:ENSG00000185634 euGenes: HUgn399694
    ECgene: SHC4 Kegg: 399694 H-InvDB: SHC4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SHC4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SHC4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SHC4 gene:
    Search GeneIP for patents involving SHC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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