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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SHC4 Gene

protein-coding   GIFtS: 51
GCID: GC15M049115

SHC (Src homology 2 domain containing) family, member 4
 Explore 9 diseases affiliated with
SHC4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SHC4    

Aliases
for SHC4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SHC (Src Homology 2 Domain Containing) Family, Member 41 2     HShcD1
RaLP1 2 3     SH2 Domain Protein C42 3
Rai-Like Protein2 3     SHC-Transforming Protein D2 3
Src Homology 2 Domain-Containing-Transforming Protein C42 3     SHC-Transforming Protein 42
SHCD2 3     

External Ids:    HGNC: 167431   Entrez Gene: 3996942   Ensembl: ENSG000001856347   UniProtKB: Q6S5L83   

Export aliases for SHC4 gene to outside databases

Previous GC identifers: GC15M046904 GC15M025948


Summaries
for SHC4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SHC4_HUMAN, Q6S5L8
Function: Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early
phases of agrin-induced tyrosine phosphorylation of CHRNB1




Genomic Views
for SHC4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SHC4 gene promoter:
         HOXA9   HOXA9B   RP58   Bach2   HSF1 (long)   Tal-1beta   Meis-1b   E47   HSF1short   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SHC4 promoter sequence
   Search SABiosciences Chromatin IP Primers for SHC4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.1-q21.2   Ensembl cytogenetic band:  15q21.1   HGNC cytogenetic band: 15q21.1-q21.2

SHC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHC4 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M049115:  view genomic region     (about GC identifiers)

Start:
 49,115,932 bp from pter      End:
 49,255,641 bp from pter
Size:
 139,710 bases      Orientation:
 minus strand

Proteins
for SHC4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SHC4_HUMAN, Q6S5L8 (See protein sequence)
Recommended Name: SHC-transforming protein 4  
Size: 630 amino acids; 68785 Da
Subunit: Interacts (via PID domain) with phosphorylated MUSK (via NPXY motif); undergoes tyrosine phosphorylation
downstream of activated MUSK. Interacts with GRB2; the interaction is dependent of Tyr-424 phosphorylation and
increased by EGF
Subcellular location: Cell junction, synapse, postsynaptic cell membrane. Note=Colocalized with MUSK at the
neuromuscular junction (By similarity)
Secondary accessions: Q6UXQ3 Q8IYW3
Alternative splicing: 2 isoforms:  Q6S5L8-1   Q6S5L8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SHC4: NX_Q6S5L8

Post-translational modifications:

  • Phosphorylated; the phosphorylation is enhanced by EGF. Phosphorylation at Tyr-424 is required for the interaction with
    • GRB21
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6S5L8

    • SHC4 Protein expression data from MOPED and PaxDb:    About this image 
    SHC4 Protein Expression
    REFSEQ proteins: NP_976224.3  
    ENSEMBL proteins: 
     ENSP00000329668   ENSP00000379786   ENSP00000443300   ENSP00000453344   ENSP00000453397  

    Human Recombinant Protein Products for SHC4: 
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    Novus Biologicals SHC4 Protein
    Novus Biologicals SHC4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SHC4

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005886plasma membrane IEA--
    GO:0030054cell junction IEA--
    GO:0045211postsynaptic membrane IEA--

    SHC4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SHC4

    Protein Domains /
    Families
    for SHC4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SHC4 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR006020 PTyr_interaction_dom
     IPR006019 PID_domain
     IPR000980 SH2
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q6S5L8

    ProtoNet protein and cluster: Q6S5L8

    2 Blocks protein families:
    IPB006019 SHC phosphotyrosine interaction domain signature
    IPB006020 Phosphotyrosine interaction domain


    UniProtKB/Swiss-Prot: SHC4_HUMAN, Q6S5L8
    Similarity: Contains 1 PID domain
    Similarity: Contains 1 SH2 domain


    Function
    for SHC4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SHC4_HUMAN, Q6S5L8
    Function: Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early
    phases of agrin-induced tyrosine phosphorylation of CHRNB1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019904protein domain specific binding IEA--
    GO:0030971receptor tyrosine kinase binding IEA--
         
    SHC4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SHC4:
     Decreased TP53 protein express  Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SHC4 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SHC4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SHC4
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate SHC4 (see all 33):
    hsa-miR-142-5p hsa-miR-607 hsa-miR-488 hsa-miR-218 hsa-miR-3167 hsa-miR-124 hsa-miR-489 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SHC4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SHC4 (see all 4)
    OriGene shRNA RFP: SHC4
    OriGene siRNA: SHC4
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    Sirion Biotech Custom design and validation of potent shRNA sequences against SHC4 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SHC4 
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHC4


    Pathways & Interactions
    for SHC4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Chronic myeloid leukemia
    		Chronic myeloid leukemia1.00
    2Glioma
    		Glioma1.00
    3Natural killer cell mediated cytotoxicity
    		Natural killer cell mediated cytotoxicity1.00
    4ErbB signaling pathway
    		ErbB signaling pathway1.00
    5Bacterial invasion of epithelial cells
    		Bacterial invasion of epithelial cells1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    5/9         Kegg Pathways  (Kegg details for SHC4) (see all 9):
        ErbB signaling pathway
    Chemokine signaling pathway
    Focal adhesion
    Natural killer cell mediated cytotoxicity
    Neurotrophin signaling pathway


    SHC4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SHC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for SHC4 (Q6S5L83 ENSP000003296684) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046263, ENSP000002695714I2D: score=1 STRING: ENSP00000269571
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    MUSKO151463I2D: score=1 
    RETP079493I2D: score=1 
    ABL1ENSP000003614234STRING: ENSP00000361423
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0035556intracellular signal transduction IEA--

    SHC4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SHC4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SHC4
    Search CenterWatch for drugs/clinical trials and news about SHC4 

    Transcripts
    for SHC4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SHC4 gene: 
    NM_203349.3  

    Unigene Cluster for SHC4:

    SHC (Src homology 2 domain containing) family, member 4
    Hs.642615  [show with all ESTs]
    Unigene Representative Sequence: NM_203349
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332408(uc010uey.1 uc010uez.1 uc001zxb.1) ENST00000396535
    ENST00000537958 ENST00000557797 ENST00000558220 ENST00000559289

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SHC4
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate SHC4 (see all 33):
    hsa-miR-142-5p hsa-miR-607 hsa-miR-488 hsa-miR-218 hsa-miR-3167 hsa-miR-124 hsa-miR-489 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SHC4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SHC4 (see all 4)
    OriGene shRNA RFP: SHC4
    OriGene siRNA: SHC4
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    Sirion Biotech Custom design and validation of potent shRNA sequences against SHC4 
    Clone
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    GenScript: all cDNA clones in your preferred vector: SHC4 (NM_203349)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SHC4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SHC4

    Additional cDNA sequence: 

    AK124916.1 AK125762.1 AK302156.1 AY358250.1 AY464565.1 BC033907.2 

    6 DOTS entries:

    DT.91698338  DT.97796043  DT.452014  DT.310466  DT.40253927  DT.91999549 

    24/64 AceView cDNA sequences (see all 64):

    AI805865 AA629213 T40374 BM673614 AI369481 AK124916 NM_203349 BQ183927 
    AY358250 BU183540 AY464565 BU852316 BM453272 AV728473 BG699422 AA333137 
    AI027957 AI631176 BQ671617 AI382937 AA296615 AI028748 AW196944 AW274966 

    GeneLoc Exon Structure


    Expression
    for SHC4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SHC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTATTTTAAT
    SHC4 Expression
    About this image

    SHC4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleMature Granulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    TGF?3+BMP7-induced chondrocytes (Chondrogenic HyStem+...)
    HyStem+TGF?3+GDF5-induced E15 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage

    See SHC4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SHC4

    SOURCE GeneReport for Unigene cluster: Hs.642615

    UniProtKB/Swiss-Prot: SHC4_HUMAN, Q6S5L8
    Tissue specificity: Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly
    expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor
    cells acquire migratory competence and invasive potential

        SABiosciences Custom PCR Arrays for SHC4
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    In Situ
    Assay Products:     
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    Orthologs
    for SHC4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SHC4 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SHC41 SHC (Src homology 2 domain containing) family, member more 69.79(n)
    68.8(a)    		   426482  XM_424123.3  XP_424123.3 
    lizard
    (Anolis carolinensis)    		 Reptilia SHC46
    		 --
    		 57(a)
    		 1 ↔ 1
    		 GL343506.1(324957-368996)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Shc6
    		 SHC-adaptor protein
    		 36(a)
    		 1 → many
    		 3L(9420110-9421771)
    worm
    (Caenorhabditis elegans)    		 Secernentea shc-16
    		 SHC (Src Homology domain C-terminal) adaptor homol...
    		 28(a)
    		 1 → many
    		 I(969683-973140)


    ENSEMBL Gene Tree for SHC4 (if available)
    TreeFam Gene Tree for SHC4 (if available) 

    Paralogs
    for SHC4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SHC4 gene
    SHC12  SHC22  SHC32  
    4 SIMAP similar genes for SHC4 using alignment to 4 protein entries:     SHC4_HUMAN (see all proteins):
    SHC1    SHC3    SHC2    PTPN11

    SHC4 for paralogs           About GeneDecksing



    Genomic Variants
    for SHC4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2287 NCBI SNPs in SHC4 are shown (see all 2287)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs110706541,2
    		C,F,A,H--49115575(+) AGAATC/TCCAGC 1 -- ds500121Minor allele frequency- T:0.27NS EA NA WA 2352
    rs753110481,2
    		--49115730(+) ATTCTG/ATTAGC 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs1155319431,2
    		--49115786(+) TCCCTC/TCTGAT 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs747646281,2
    		F--49115838(+) ATAAAC/TTCACC 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1479861881,2
    		--49115862(+) TTTGAC/TTGAGC 1 -- ds50010--------
    rs1877714681,2
    		--49115901(+) ATGACA/CGTTTC 1 -- ds50010--------
    rs1928940111,2
    		--49115930(+) CATATG/TCTGTC 1 -- ds50010--------
    rs1416146091,2
    		--49115973(+) AAAGTC/TGTTTA 1 -- ut310--------
    rs1848042891,2
    		--49115974(+) AAGTCA/GTTTAC 1 -- ut310--------
    rs1884710951,2
    		--49116084(+) ACTGTA/GTCTGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SHC4 (49115932 - 49255641 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SHC4: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SHC4
    DNA2.0 Custom Variant and Variant Library Synthesis for SHC4

    Disorders / Diseases
    for SHC4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SHC4 for disorders           About GeneDecksing

    9 diseases for SHC4:    About MalaCards
    urethral stricture    vestibular nystagmus    major depressive disorder    nystagmus
    chronic myeloid leukemia    myeloid leukemia    urethritis    leukemia
    melanoma

    2 diseases from the University of Copenhagen DISEASES database for SHC4:
    Prostate cancer     Urethral stricture
    Human Genome Epidemiology (HuGE) Navigator: SHC4 (1 document)

    Export disorders for SHC4 gene to outside databases

    Publications
    for SHC4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SHC4 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SHC4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. RaLP, a new member of the Src homology and collagen family, regulates cell migration and tumor growth of metastatic melanomas. (PubMed id 17409413)1, 2 Fagiani E.... Lanfrancone L. (2007)
    2. Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase. (PubMed id 17452444)1, 2 Jones N.... Pawson T. (2007)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. Genome-wide association analysis of eating disorder-re lated symptoms, behaviors, and personality traits. (PubMed id 22911880)1 Boraska V....Zeggini E. (2012)
    5. Genome-wide association analysis of gender difference s in major depressive disorder in the Netherlands NESDA and NTR population-base d samples. (PubMed id 21621269)1 Aragam N....Pan Y. (2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. ShcD interacts with TrkB via its PTB and SH2 domains and regulates BDNF-induced MAPK activation. (PubMed id 20663410)1 You Y....Peng X. (2010)
    8. [ShcD interacts with TrkC through its PTB and SH2 doma ins]. (PubMed id 20078941)1 You Y.G....Peng X.Z. (2009)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for SHC4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing SHC4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 399694 HGNC: 16743 AceView: RaLP Ensembl:ENSG00000185634 euGenes: HUgn399694
    ECgene: SHC4 Kegg: 399694 H-InvDB: SHC4

    Other Databases showing SHC4 gene

    (According to HUGE)
    About This Section
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    Specialized Databases showing SHC4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SHC4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SHC4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SHC4 gene:
    Search GeneIP for patents involving SHC4

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