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SHC3 Gene

protein-coding   GIFtS: 61
GCID: GC09M091628

SHC (Src Homology 2 Domain Containing) Transforming Protein...

(Previous name: src homology 2 domain containing transforming protein C3)
  Search for SHC3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SHC (Src Homology 2 Domain Containing) Transforming Protein 31 2     SH2 Domain Protein C32 3
Neuronal Shc2 3     SHC-Transforming Protein C2 3
Protein Rai2 3     Src Homology 2 Domain Containing Transforming Protein C31
Src Homology 2 Domain-Containing-Transforming Protein C32 3     RAI2
N-Shc2 3     SHC-Transforming Protein 32
NSHC2 3     Src Homology 2 Domain-Containing Transforming Protein C32
SHCC2 3     

External Ids:    HGNC: 181811   Entrez Gene: 533582   Ensembl: ENSG000001480827   OMIM: 6052635   UniProtKB: Q925293   

Export aliases for SHC3 gene to outside databases

Previous GC identifers: GC09M082643 GC09M083496 GC09M085215 GC09M087117 GC09M088857 GC09M090817 GC09M061453


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SHC3 Gene:
SHC3 (SHC (Src homology 2 domain containing) transforming protein 3) is a protein-coding gene. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is SHC4.

UniProtKB/Swiss-Prot: SHC3_HUMAN, Q92529
Function: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons.
Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons

Gene Wiki entry for SHC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SHC3 gene promoter:
         C/EBPbeta   HSF1 (long)   Lmo2   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   C/EBPalpha   PPAR-gamma1   HSF1short   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SHC3 promoter sequence
   Search Chromatin IP Primers for SHC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SHC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.1   Ensembl cytogenetic band:  9q22.1   HGNC cytogenetic band: 9q22.1

SHC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHC3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M091628:  view genomic region     (about GC identifiers)

Start:
91,620,686 bp from pter      End:
91,793,682 bp from pter
Size:
172,997 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SHC3_HUMAN, Q92529 (See protein sequence)
Recommended Name: SHC-transforming protein 3  
Size: 594 amino acids; 64056 Da
Subunit: Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2.
Interacts with activated EGF receptors
Secondary accessions: Q5T7I7 Q8TAP2 Q9UCX5
Alternative splicing: 2 isoforms:  Q92529-1   Q92529-2   

Explore the universe of human proteins at neXtProt for SHC3: NX_Q92529

Explore proteomics data for SHC3 at MOPED

Post-translational modifications: 

  • Tyrosine phosphorylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SHC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_058544.3  
    ENSEMBL proteins: 
     ENSP00000364995   ENSP00000364991   ENSP00000364990  
    Reactome Protein details: Q92529

    SHC3 Human Recombinant Protein Products:

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    Novus Biologicals SHC3 Proteins
    Novus Biologicals SHC3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SHC3

     
    Search eBioscience for Proteins for SHC3 

    SHC3 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for SHC3

    SHC3 Assay Products:

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    Search eBioscience for ELISAs for SHC3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    4 InterPro protein domains:
     IPR011993 PH_like_dom
     IPR006020 PTB/PI_dom
     IPR006019 PID_Shc-like
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q92529

    ProtoNet protein and cluster: Q92529

    2 Blocks protein domains:
    IPB006019 SHC phosphotyrosine interaction domain signature
    IPB006020 Phosphotyrosine interaction domain


    UniProtKB/Swiss-Prot: SHC3_HUMAN, Q92529
    Similarity: Contains 1 PID domain
    Similarity: Contains 1 SH2 domain


    Find genes that share domains with SHC3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SHC3_HUMAN, Q92529
    Function: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons.
    Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity TAS8808684
    GO:0005515protein binding IPI11877420
         
    Find genes that share ontologies with SHC3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for SHC3:
     G0/1 arrest  Increased G1 DNA content  Upregulation of Wnt/beta-caten 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Shc3):
     nervous system 

    Find genes that share phenotypes with SHC3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SHC3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SHC3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SHC3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SHC3

    miRNA
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    miRTarBase miRNAs that target SHC3:
    hsa-mir-335-5p (MIRT018309), hsa-mir-92a-3p (MIRT049052), hsa-mir-124-3p (MIRT002724)

    Block miRNA regulation of human, mouse, rat SHC3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SHC3 (see all 96):
    hsa-miR-549 hsa-miR-3194-5p hsa-miR-631 hsa-miR-519a hsa-miR-550a* hsa-miR-3116 hsa-miR-130b hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidSHC3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SHC3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SHC3 (NM_016848)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SHC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHC3

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHC3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    endoplasmic reticulum1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with SHC3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SHC3 About   (see all 20)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    Focal Adhesion0.65
    2ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    3Insulin receptor signalling cascade
    Insulin receptor signalling cascade0.94
    SHC-related events0.00
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    SHC-mediated signalling0.00
    IGF1R signaling cascade0.92
    SHC-related events triggered by IGF1R0.00
    Signaling by Insulin receptor0.80
    Signal attenuation0.00
    4Signalling to ERKs
    Signalling to ERKs0.73
    Signalling to RAS0.73
    5Signaling by FGFR
    NGF signalling via TRKA from the plasma membrane0.71
    Signalling by NGF0.71


    Find genes that share SuperPaths with SHC3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 BioSystems Pathways for SHC3
        Focal Adhesion
    Integrin-mediated cell adhesion
    Insulin Signaling
    BDNF signaling pathway
    Neurotrophic factor-mediated Trk receptor signaling

    3 Reactome Pathways for SHC3
        SHC-mediated signalling
    Signal attenuation
    Signalling to RAS

    1 PharmGKB Pathway for SHC3
        EGFR Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for SHC3) (see all 13):
        ErbB signaling pathway
    Ras signaling pathway
    Chemokine signaling pathway
    Focal adhesion
    Natural killer cell mediated cytotoxicity

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SHC3
    Interactions:

        GeneGlobe Interaction Network for SHC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SHC3 (Q925291, 2, 3 ENSP000003649954) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046261, 2, 3, ENSP000002695714EBI-79084,EBI-641062 MINT-74742 MINT-74743 I2D: score=2 STRING: ENSP00000269571
    APPP050671, 3, ENSP000002849814EBI-79084,EBI-77613 I2D: score=4 STRING: ENSP00000284981
    ERBB3P218601, 2, 3, ENSP000002671014EBI-79084,EBI-720706 MINT-74745 MINT-74744 I2D: score=2 STRING: ENSP00000267101
    EGFRP005332, 3, ENSP000002754934MINT-74741 I2D: score=4 STRING: ENSP00000275493
    SH3GL3Q999632, 3, ENSP000003913724MINT-8270693 I2D: score=2 STRING: ENSP00000391372
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway TAS8808684
    GO:0007173epidermal growth factor receptor signaling pathway TAS8808684
    GO:0007265Ras protein signal transduction TAS--
    GO:0007417central nervous system development TAS8808684
    GO:0007611learning or memory IEA--

    Find genes that share ontologies with SHC3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SHC3

    2 Novoseek inferred chemical compound relationships for SHC3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphotyrosine 75.2 2 8662772 (1), 8808684 (1)
    tyrosine 61.4 5 8610109 (1), 11791173 (1), 9507002 (1), 15735675 (1) (see all 5)



    Find genes that share compounds with SHC3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SHC3 gene: 
    NM_016848.5  

    Unigene Cluster for SHC3:

    SHC (Src homology 2 domain containing) transforming protein 3
    Hs.292737  [show with all ESTs]
    Unigene Representative Sequence: NM_016848
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375835(uc004aqf.2) ENST00000375831 ENST00000375830
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SHC3 (see all 96):
    hsa-miR-549 hsa-miR-3194-5p hsa-miR-631 hsa-miR-519a hsa-miR-550a* hsa-miR-3116 hsa-miR-130b hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidSHC3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SHC3
    Clone
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat SHC3
      QuantiFast Probe-based Assays in human, mouse, rat SHC3

    Additional mRNA sequence: 

    AK127258.1 AK129921.1 BC026314.1 BC042431.1 BX538228.1 BX641139.1 D84361.1 

    6 DOTS entries:

    DT.97766224  DT.311928  DT.101963669  DT.40297564  DT.92418322  DT.95266049 

    Selected AceView cDNA sequences (see all 41):

    D84361 N92201 BM805542 BF195644 AI470442 AA725165 BX098090 BF940521 
    BX117015 BI524301 AW291451 CK000348 BC026314 BE046017 N53508 BX641139 
    AL133954 NM_016848 AW294374 AI457726 BU754118 AI915149 W48628 N64471 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SHC3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b
    SP1:              -     -     -                 -                                                           -               
    SP2:                                                                                            -           -               
    SP3:                                                                                                                        
    SP4:                                                                                                                        


    ECgene alternative splicing isoforms for SHC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SHC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGTCTGCA
    SHC3 Expression
    About this image


    SHC3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
             Line H9 (Naive)
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Medulla Oblongata
             Oligodendrocyte progenitor cells
     
     Spinal Cord (Nervous System)
             Oligodendrocyte progenitor cells
     
     Oligodendrocytes (Nervous System)
             Oligodendrocyte progenitor cells
    SHC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SHC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.292737

    UniProtKB/Swiss-Prot: SHC3_HUMAN, Q92529
    Tissue specificity: Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly
    expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and
    amygdala. Expressed at low level in the cerebellum, medulla and spinal cord

        Custom PCR Arrays for SHC3
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    QuantiFast Probe-based Assays in human, mouse, rat SHC3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SHC3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Shc31 , 5 src homology 2 domain-containing transforming protein more1, 5 87.24(n)1
    91.33(a)1
      13 (26.12 cM)5
    204181  NM_009167.31  NP_033193.21 
     514310415 
    chicken
    (Gallus gallus)
    Aves SHC31 SHC (Src homology 2 domain containing) transforming more 69.83(n)
    71.24(a)
      431265  XM_004949245.1  XP_004949302.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia shc31 SHC (Src homology 2 domain containing) transforming more 66.04(n)
    67.29(a)
      100101768  NM_001100264.1  NP_001093734.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003321111 SHC-transforming protein 3-like 64.83(n)
    63.52(a)
      100332111  XM_002665837.3  XP_002665883.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Shc3 EGF receptor signaling pathway 34(a)   3 67B4   --
    worm
    (Caenorhabditis elegans)
    Secernentea shc-16
    Protein SHC-1, isoform a
    29(a)
    1 → many
    I(969680-973137) WBGene00018788


    ENSEMBL Gene Tree for SHC3 (if available)
    TreeFam Gene Tree for SHC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SHC3 gene
    SHC42  SHC12  SHC22  
    9 SIMAP similar genes for SHC3 using alignment to 2 protein entries:     SHC3_HUMAN (see all proteins):
    SH2D3C    CRK    FER    SH2D3A    SHC1    SHC4
    SHC2    SH2B2    GRB14

    Find genes that share paralogs with SHC3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SHC3 (see all 2967)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1485573051,2
    --91620752(+) CTGTTG/TAGAAA 1 -- ut310--------
    rs1433177271,2
    --91620795(+) TTCCAC/TGCTGG 1 -- ut310--------
    rs1466813751,2
    C--91620920(+) GTTTTC/TAGTAT 1 -- ut310--------
    rs1402393981,2
    C--91620930(+) TCTAAA/GTCAGA 1 -- ut310--------
    rs1452032521,2
    --91621114(+) TTGGCA/GATCCC 1 -- ut310--------
    rs78659791,2
    C,F,A,H--91621197(+) GAAGGA/GATCCC 1 -- ut3123Minor allele frequency- N:0.00EA NA NS WA 2560
    rs1180179651,2
    C,F--91621261(+) GTATTC/GTCAAA 1 -- ut311Minor allele frequency- G:0.01NA 120
    rs1510151031,2
    C--91621306(+) TTGTCA/GTAGAA 1 -- ut310--------
    rs1408973331,2
    --91621362(+) GGGATA/GTCAAA 1 -- ut310--------
    rs764322541,2
    C,F--91621405(+) GTGGTG/AAATTG 1 -- ut312Minor allele frequency- A:0.05WA NA 238

    HapMap Linkage Disequilibrium report for SHC3 (91620686 - 91793682 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SHC3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2738726CNV Deletion23290073
    esv2554035CNV Insertion19546169
    nsv6608CNV Loss18451855
    esv26782CNV Loss19812545
    nsv819886CNV Loss19587683
    nsv893556CNV Gain21882294
    nsv831651CNV Gain17160897
    esv29340CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SHC3
    DNA2.0 Custom Variant and Variant Library Synthesis for SHC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605263    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for SHC3:
    Hepatocellular carcinoma

    Find genes that share disorders with SHC3           About GenesLikeMe

    2 Novoseek inferred disease relationships for SHC3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma 10.6 1 15735675 (1)
    tumors 0 1 15867224 (1)

    Genetic Association Database (GAD): SHC3
    Human Genome Epidemiology (HuGE) Navigator: SHC3 (2 documents)

    Export disorders for SHC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SHC3 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with SHC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway. (PubMed id 8808684)1, 2, 3, 9 Nakamura T.... Mori N. (Oncogene 1996)
    2. A family of Shc related proteins with conserved PTB, CH1 and SH2 regions. (PubMed id 8760305)1, 2, 9 Pelicci G....Pelicci P.-G. (Oncogene 1996)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence. (PubMed id 17179996)1, 4 Li M.D....Ma J.Z. (Mol. Psychiatry 2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. ShcB and ShcC activation by the Trk family of receptor tyrosine kinases. (PubMed id 12006576)1, 2 Liu H.Y. and Meakin S.O. (J. Biol. Chem. 2002)
    7. Domain-specific function of ShcC docking protein in neuroblastoma cells. (PubMed id 15735675)1, 9 Miyake I....Sakai R. (Oncogene 2005)
    8. N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling. (PubMed id 9507002)1, 9 Nakamura T.... Mori N. (J. Biol. Chem. 1998)
    9. A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. (PubMed id 8610109)1, 9 O'Bryan J.P....Pawson T. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    10. Two adaptor proteins differentially modulate the phosphorylation and biophysics of Kv1.3 ion channel by SRC kinase. (PubMed id 11812778)1, 9 Cook K.K. and Fadool D.A. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 53358 HGNC: 18181 AceView: SHC3 Ensembl:ENSG00000148082 euGenes: HUgn53358
    ECgene: SHC3 Kegg: 53358 H-InvDB: SHC3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SHC3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SHC3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SHC3 gene:
    Search GeneIP for patents involving SHC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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