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Aliases for SHC3 Gene

Aliases for SHC3 Gene

  • SHC (Src Homology 2 Domain Containing) Transforming Protein 3 2 3
  • Src Homology 2 Domain-Containing-Transforming Protein C3 3 4
  • SHC-Transforming Protein C 3 4
  • SH2 Domain Protein C3 3 4
  • Neuronal Shc 3 4
  • Protein Rai 3 4
  • N-Shc 3 4
  • NSHC 3 4
  • SHCC 3 4
  • Src Homology 2 Domain Containing Transforming Protein C3 2
  • Src Homology 2 Domain-Containing Transforming Protein C3 3
  • SHC-Transforming Protein 3 3
  • RAI 3

External Ids for SHC3 Gene

Summaries for SHC3 Gene

GeneCards Summary for SHC3 Gene

SHC3 (SHC (Src Homology 2 Domain Containing) Transforming Protein 3) is a Protein Coding gene. Diseases associated with SHC3 include neuroblastoma. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is SHC1.

UniProtKB/Swiss-Prot for SHC3 Gene

  • Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons

Gene Wiki entry for SHC3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHC3 Gene

Genomics for SHC3 Gene

Genomic Location for SHC3 Gene

89,005,771 bp from pter
89,178,767 bp from pter
172,997 bases
Minus strand

Genomic View for SHC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SHC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHC3 Gene

Proteins for SHC3 Gene

  • Protein details for SHC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SHC-transforming protein 3
    Protein Accession:
    Secondary Accessions:
    • Q5T7I7
    • Q8TAP2
    • Q9UCX5

    Protein attributes for SHC3 Gene

    594 amino acids
    Molecular mass:
    64056 Da
    Quaternary structure:
    • Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors.

    Alternative splice isoforms for SHC3 Gene


neXtProt entry for SHC3 Gene

Proteomics data for SHC3 Gene at MOPED

Post-translational modifications for SHC3 Gene

Other Protein References for SHC3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SHC3 Gene

Domains for SHC3 Gene

Gene Families for SHC3 Gene

  • SH2D :SH2 domain containing


  • Contains 1 PID domain.:
    • Q92529
  • Contains 1 SH2 domain.:
    • Q92529
genes like me logo Genes that share domains with SHC3: view

Function for SHC3 Gene

Molecular function for SHC3 Gene

UniProtKB/Swiss-Prot Function: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons

Gene Ontology (GO) - Molecular Function for SHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity TAS 8808684
GO:0005515 protein binding IPI 11877420
GO:0019901 protein kinase binding IBA --
GO:0030971 receptor tyrosine kinase binding IBA --
genes like me logo Genes that share ontologies with SHC3: view

Phenotypes for SHC3 Gene

genes like me logo Genes that share phenotypes with SHC3: view

miRNA for SHC3 Gene

miRTarBase miRNAs that target SHC3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SHC3 Gene

Localization for SHC3 Gene

Subcellular locations from

Jensen Localization Image for SHC3 Gene COMPARTMENTS Subcellular localization image for SHC3 gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with SHC3: view

Pathways for SHC3 Gene

genes like me logo Genes that share pathways with SHC3: view

Gene Ontology (GO) - Biological Process for SHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS 8808684
GO:0007173 epidermal growth factor receptor signaling pathway TAS 8808684
GO:0007265 Ras protein signal transduction TAS --
GO:0007417 central nervous system development IEA --
genes like me logo Genes that share ontologies with SHC3: view

Compounds for SHC3 Gene

(2) Novoseek inferred chemical compound relationships for SHC3 Gene

Compound -log(P) Hits PubMed IDs
phosphotyrosine 75.2 2
tyrosine 61.4 5
genes like me logo Genes that share compounds with SHC3: view

Transcripts for SHC3 Gene

mRNA/cDNA for SHC3 Gene

Unigene Clusters for SHC3 Gene

SHC (Src homology 2 domain containing) transforming protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SHC3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - - -
SP2: - -

Relevant External Links for SHC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SHC3 Gene

mRNA expression in normal human tissues for SHC3 Gene

mRNA differential expression in normal tissues according to GTEx for SHC3 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (6.2), Brain - Frontal Cortex (BA9) (5.8), and Brain - Cortex (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SHC3 Gene

SOURCE GeneReport for Unigene cluster for SHC3 Gene Hs.292737

mRNA Expression by UniProt/SwissProt for SHC3 Gene

Tissue specificity: Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord.
genes like me logo Genes that share expressions with SHC3: view

Orthologs for SHC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SHC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SHC3 36
  • 99.38 (n)
  • 99.66 (a)
SHC3 37
  • 100 (a)
(Bos Taurus)
Mammalia SHC3 36
  • 86.09 (n)
  • 88.73 (a)
SHC3 37
  • 92 (a)
(Canis familiaris)
Mammalia SHC3 36
  • 87.61 (n)
  • 90.6 (a)
SHC3 37
  • 91 (a)
(Mus musculus)
Mammalia Shc3 36
  • 87.24 (n)
  • 91.33 (a)
Shc3 16
Shc3 37
  • 91 (a)
(Monodelphis domestica)
Mammalia SHC3 37
  • 64 (a)
(Rattus norvegicus)
Mammalia Shc3 36
  • 88.14 (n)
  • 91.36 (a)
(Gallus gallus)
Aves SHC3 36
  • 69.83 (n)
  • 71.24 (a)
SHC3 37
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia shc3 36
  • 66.04 (n)
  • 67.29 (a)
(Danio rerio)
Actinopterygii LOC100332111 36
  • 64.83 (n)
  • 63.52 (a)
SHC3 37
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta Shc 37
  • 38 (a)
Shc 38
  • 34 (a)
(Caenorhabditis elegans)
Secernentea shc-1 37
  • 29 (a)
Species with no ortholog for SHC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SHC3 Gene

Gene Tree for SHC3 (if available)
Gene Tree for SHC3 (if available)

Paralogs for SHC3 Gene

Paralogs for SHC3 Gene

Selected SIMAP similar genes for SHC3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SHC3: view

Variants for SHC3 Gene

Sequence variations from dbSNP and Humsavar for SHC3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs12519 -- 89,013,167(-) GCTGT(A/G)TGTTT utr-variant-3-prime
rs725764 -- 89,173,896(+) TTTAC(A/G)TGTAA intron-variant
rs767075 -- 89,161,078(-) CTTCC(A/C)TAGAG intron-variant
rs868819 -- 89,010,926(+) GCACC(A/G)GCCCC utr-variant-3-prime
rs868820 -- 89,010,475(+) GTGGG(C/G)GTCTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SHC3 Gene

Variant ID Type Subtype PubMed ID
nsv893556 CNV Gain 21882294
esv29340 CNV Gain+Loss 19812545
esv2554035 CNV Insertion 19546169
esv26782 CNV Loss 19812545
esv2738726 CNV Deletion 23290073
nsv831651 CNV Gain 17160897
nsv819886 CNV Loss 19587683
nsv6608 CNV Loss 18451855

Relevant External Links for SHC3 Gene

HapMap Linkage Disequilibrium report

Disorders for SHC3 Gene

(1) MalaCards Diseases for SHC3 Gene

Search for SHC3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SHC3 Gene

(2) Novoseek inferred disease relationships for SHC3 Gene

Disease -log(P) Hits PubMed IDs
lymphoma 10.6 1
tumors 0 1

Relevant External Links for SHC3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SHC3: view

No data available for UniProtKB/Swiss-Prot for SHC3 Gene

Publications for SHC3 Gene

  1. N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway. (PMID: 8808684) Nakamura T. … Mori N. (Oncogene 1996) 2 3 4 23
  2. A family of Shc related proteins with conserved PTB, CH1 and SH2 regions. (PMID: 8760305) Pelicci G. … Pelicci P.-G. (Oncogene 1996) 3 4 23
  3. N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling. (PMID: 9507002) Nakamura T. … Mori N. (J. Biol. Chem. 1998) 3 23
  4. A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. (PMID: 8610109) O'Bryan J.P. … Pawson T. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 23
  5. Two adaptor proteins differentially modulate the phosphorylation and biophysics of Kv1.3 ion channel by SRC kinase. (PMID: 11812778) Cook K.K. … Fadool D.A. (J. Biol. Chem. 2002) 3 23

Products for SHC3 Gene

Sources for SHC3 Gene

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