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Aliases for SHC3 Gene

Aliases for SHC3 Gene

  • SHC (Src Homology 2 Domain Containing) Transforming Protein 3 2 3 5
  • Src Homology 2 Domain-Containing-Transforming Protein C3 3 4
  • SHC-Transforming Protein C 3 4
  • SH2 Domain Protein C3 3 4
  • Neuronal Shc 3 4
  • Protein Rai 3 4
  • N-Shc 3 4
  • NSHC 3 4
  • SHCC 3 4
  • Src Homology 2 Domain Containing Transforming Protein C3 2
  • Src Homology 2 Domain-Containing Transforming Protein C3 3
  • RAI 3

External Ids for SHC3 Gene

Previous GeneCards Identifiers for SHC3 Gene

  • GC09M082643
  • GC09M083496
  • GC09M085215
  • GC09M087117
  • GC09M088857
  • GC09M090817
  • GC09M091628
  • GC09M061453

Summaries for SHC3 Gene

GeneCards Summary for SHC3 Gene

SHC3 (SHC (Src Homology 2 Domain Containing) Transforming Protein 3) is a Protein Coding gene. Diseases associated with SHC3 include Sclerosing Hepatic Carcinoma. Among its related pathways are Bacterial invasion of epithelial cells and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include protein kinase binding and receptor tyrosine kinase binding. An important paralog of this gene is SHC1.

UniProtKB/Swiss-Prot for SHC3 Gene

  • Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.

Gene Wiki entry for SHC3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHC3 Gene

Genomics for SHC3 Gene

Regulatory Elements for SHC3 Gene

Enhancers for SHC3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SHC3 on UCSC Golden Path with GeneCards custom track

Promoters for SHC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SHC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SHC3 Gene

89,005,771 bp from pter
89,182,072 bp from pter
176,302 bases
Minus strand

Genomic View for SHC3 Gene

Genes around SHC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHC3 Gene

Proteins for SHC3 Gene

  • Protein details for SHC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SHC-transforming protein 3
    Protein Accession:
    Secondary Accessions:
    • Q5T7I7
    • Q8TAP2
    • Q9UCX5

    Protein attributes for SHC3 Gene

    594 amino acids
    Molecular mass:
    64056 Da
    Quaternary structure:
    • Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors.

    Alternative splice isoforms for SHC3 Gene


neXtProt entry for SHC3 Gene

Proteomics data for SHC3 Gene at MOPED

Post-translational modifications for SHC3 Gene

Other Protein References for SHC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHC3 Gene

Domains & Families for SHC3 Gene

Gene Families for SHC3 Gene

Suggested Antigen Peptide Sequences for SHC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PID domain.
  • Contains 1 PID domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SHC3: view

Function for SHC3 Gene

Molecular function for SHC3 Gene

UniProtKB/Swiss-Prot Function:
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
genes like me logo Genes that share phenotypes with SHC3: view

Animal Models for SHC3 Gene

MGI Knock Outs for SHC3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SHC3 Gene

Localization for SHC3 Gene

Subcellular locations from

Jensen Localization Image for SHC3 Gene COMPARTMENTS Subcellular localization image for SHC3 gene
Compartment Confidence
cytosol 5
plasma membrane 3
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SHC3 Gene

Pathways & Interactions for SHC3 Gene

SuperPathways for SHC3 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Focal Adhesion
3 ErbB signaling pathway
4 Developmental Biology
5 Immune System
genes like me logo Genes that share pathways with SHC3: view

SIGNOR curated interactions for SHC3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS 8808684
GO:0007173 epidermal growth factor receptor signaling pathway TAS 8808684
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with SHC3: view

Drugs & Compounds for SHC3 Gene

(1) Drugs for SHC3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SHC3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SHC3: view

Transcripts for SHC3 Gene

mRNA/cDNA for SHC3 Gene

Unigene Clusters for SHC3 Gene

SHC (Src homology 2 domain containing) transforming protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SHC3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - - -
SP2: - -

Relevant External Links for SHC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SHC3 Gene

mRNA expression in normal human tissues for SHC3 Gene

mRNA differential expression in normal tissues according to GTEx for SHC3 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x6.2), Brain - Frontal Cortex (BA9) (x5.8), and Brain - Cortex (x4.8).

Protein differential expression in normal tissues from HIPED for SHC3 Gene

This gene is overexpressed in Frontal cortex (45.1) and Ovary (23.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SHC3 Gene

SOURCE GeneReport for Unigene cluster for SHC3 Gene Hs.292737

mRNA Expression by UniProt/SwissProt for SHC3 Gene

Tissue specificity: Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord.
genes like me logo Genes that share expression patterns with SHC3: view

Protein tissue co-expression partners for SHC3 Gene

- Elite partner

Primer Products

Orthologs for SHC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SHC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SHC3 35
  • 86.09 (n)
  • 88.73 (a)
SHC3 36
  • 92 (a)
(Canis familiaris)
Mammalia SHC3 35
  • 87.61 (n)
  • 90.6 (a)
SHC3 36
  • 91 (a)
(Mus musculus)
Mammalia Shc3 35
  • 87.24 (n)
  • 91.33 (a)
Shc3 16
Shc3 36
  • 91 (a)
(Pan troglodytes)
Mammalia SHC3 35
  • 99.38 (n)
  • 99.66 (a)
SHC3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Shc3 35
  • 88.14 (n)
  • 91.36 (a)
(Monodelphis domestica)
Mammalia SHC3 36
  • 64 (a)
(Gallus gallus)
Aves SHC3 35
  • 69.83 (n)
  • 71.24 (a)
SHC3 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia shc3 35
  • 66.04 (n)
  • 67.29 (a)
(Danio rerio)
Actinopterygii LOC100332111 35
  • 64.83 (n)
  • 63.52 (a)
SHC3 36
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta Shc 37
  • 34 (a)
Shc 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea shc-1 36
  • 29 (a)
Species with no ortholog for SHC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SHC3 Gene

Gene Tree for SHC3 (if available)
Gene Tree for SHC3 (if available)

Paralogs for SHC3 Gene

Paralogs for SHC3 Gene

(9) SIMAP similar genes for SHC3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SHC3: view

Variants for SHC3 Gene

Sequence variations from dbSNP and Humsavar for SHC3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs725764 -- 89,173,896(+) TTTAC(A/G)TGTAA intron-variant
rs767075 -- 89,161,078(-) CTTCC(A/C)TAGAG intron-variant
rs868819 -- 89,010,926(+) GCACC(A/G)GCCCC utr-variant-3-prime
rs868820 -- 89,010,475(+) GTGGG(C/G)GTCTC utr-variant-3-prime
rs944477 -- 89,025,112(+) CCCTT(A/C)TAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SHC3 Gene

Variant ID Type Subtype PubMed ID
nsv893556 CNV Gain 21882294
esv29340 CNV Gain+Loss 19812545
esv2554035 CNV Insertion 19546169
esv26782 CNV Loss 19812545
esv2738726 CNV Deletion 23290073
nsv831651 CNV Gain 17160897
nsv819886 CNV Loss 19587683
nsv6608 CNV Loss 18451855

Variation tolerance for SHC3 Gene

Residual Variation Intolerance Score: 13.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.86% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SHC3 Gene

Disorders for SHC3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SHC3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
sclerosing hepatic carcinoma
  • sclerosing hepatocellular carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search SHC3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SHC3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SHC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SHC3 Gene

Publications for SHC3 Gene

  1. N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway. (PMID: 8808684) Nakamura T. … Mori N. (Oncogene 1996) 2 3 4 23 67
  2. Domain-specific function of ShcC docking protein in neuroblastoma cells. (PMID: 15735675) Miyake I. … Sakai R. (Oncogene 2005) 3 23
  3. Two adaptor proteins differentially modulate the phosphorylation and biophysics of Kv1.3 ion channel by SRC kinase. (PMID: 11812778) Cook K.K. … Fadool D.A. (J. Biol. Chem. 2002) 3 23
  4. N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling. (PMID: 9507002) Nakamura T. … Mori N. (J. Biol. Chem. 1998) 3 23
  5. A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. (PMID: 8610109) O'Bryan J.P. … Pawson T. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 23

Products for SHC3 Gene

Sources for SHC3 Gene