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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SHC3 Gene

protein-coding   GIFtS: 61
GCID: GC09M091628

SHC (Src homology 2 domain containing) transforming protein...

(Previous name: src homology 2 domain containing transforming protein C3...)
 Explore 17 diseases affiliated with
SHC3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SHC3    

Aliases
for SHC3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SHC (Src Homology 2 Domain Containing) Transforming Protein 31 2     SH2 Domain Protein C32 3
N-Shc1 2 3     SHC-Transforming Protein C2 3
NSHC1 2 3     Src Homology 2 Domain Containing Transforming Protein C31
SHCC1 2 3     RAI2
Neuronal Shc2 3     SHC-Transforming Protein 32
Protein Rai2 3     Src Homology 2 Domain-Containing Transforming Protein C32
Src Homology 2 Domain-Containing-Transforming Protein C32 3     

External Ids:    HGNC: 181811   Entrez Gene: 533582   Ensembl: ENSG000001480827   OMIM: 6052635   UniProtKB: Q925293   

Export aliases for SHC3 gene to outside databases

Previous GC identifers: GC09M082643 GC09M083496 GC09M085215 GC09M087117 GC09M088857 GC09M090817 GC09M061453


Summaries
for SHC3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SHC3_HUMAN, Q92529
Function: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in
the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons

Gene Wiki entry for SHC3


Genomic Views
for SHC3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SHC3 gene promoter:
         C/EBPbeta   HSF1 (long)   Lmo2   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   C/EBPalpha   PPAR-gamma1   HSF1short   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SHC3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SHC3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.1   Ensembl cytogenetic band:  9q22.1   HGNC cytogenetic band: 9q22.1

SHC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHC3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M091628:  view genomic region     (about GC identifiers)

Start:
 91,620,686 bp from pter      End:
 91,793,682 bp from pter
Size:
 172,997 bases      Orientation:
 minus strand

Proteins
for SHC3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SHC3_HUMAN, Q92529 (See protein sequence)
Recommended Name: SHC-transforming protein 3  
Size: 594 amino acids; 64056 Da
Subunit: Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2.
Interacts with activated EGF receptors
Secondary accessions: Q5T7I7 Q8TAP2 Q9UCX5
Alternative splicing: 2 isoforms:  Q92529-1   Q92529-2   

Explore the universe of human proteins at neXtProt for SHC3: NX_Q92529

Post-translational modifications:

  • Tyrosine phosphorylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92529

    • SHC3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_058544.3  
    ENSEMBL proteins: 
     ENSP00000364995   ENSP00000364991   ENSP00000364990  
    Reactome Protein details: Q92529
    Human Recombinant Protein Products: 
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    Novus Biologicals SHC3 Proteins
    Novus Biologicals SHC3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SHC3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--


    SHC3 for ontologies           About GeneDecksing



    SHC3 Antibody Products: 
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    Uscn Antibodies for SHC3
    Search ThermoFisher Antibodies for SHC3

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    Uscn ELISAs and CLIAs for SHC3

    Protein Domains /
    Families
    for SHC3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SHC3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR006020 PTyr_interaction_dom
     IPR006019 PID_domain
     IPR000980 SH2
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q92529

    ProtoNet protein and cluster: Q92529

    2 Blocks protein families:
    IPB006019 SHC phosphotyrosine interaction domain signature
    IPB006020 Phosphotyrosine interaction domain


    UniProtKB/Swiss-Prot: SHC3_HUMAN, Q92529
    Similarity: Contains 1 PID domain
    Similarity: Contains 1 SH2 domain


    Function
    for SHC3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SHC3_HUMAN, Q92529
    Function: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in
    the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SHC3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SHC3
    8/96 QIAGEN miScript miRNA Assays for microRNAs that regulate SHC3 (see all 96):
    hsa-miR-549 hsa-miR-3194-5p hsa-miR-631 hsa-miR-519a hsa-miR-550a* hsa-miR-3116 hsa-miR-130b hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmid: SHC3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SHC3 (see all 7)
    OriGene shRNA RFP: SHC3
    OriGene siRNA: SHC3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SHC3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SHC3

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHC3 

    Cell Line
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    Search LifeMap BioReagents cell lines for SHC3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHC3

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity TAS8808684
    GO:0005515protein binding IPI11877420


    SHC3 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for SHC3:
     G0/1 arrest  Increased G1 DNA content  Upregulation of Wnt/beta-caten 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Shc3):
     nervous system 

    SHC3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SHC3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1IRS-related events
    		Insulin receptor signalling cascade0.94
    		IGF1R signaling cascade0.90
    		Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.90
    		Signaling by Insulin receptor0.74
    2SHC-mediated signalling
    		SHC-mediated signalling1.00
    		SHC-related events triggered by IGF1R0.83
    		SHC-related events0.88
    3Focal Adhesion
    		Focal Adhesion1.00
    		Integrin-mediated cell adhesion0.38
    		Focal adhesion0.66
    4Signalling to RAS
    		Signalling to RAS1.00
    		Signalling to ERKs0.73
    5ErbB signaling pathway
    		ErbB signaling pathway1.00
    		EGFR Inhibitor Pathway, Pharmacodynamics0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4 BioSystems Pathways for SHC3 
        Integrin-mediated cell adhesion
    Focal Adhesion
    Insulin Signaling
    Neurotrophic factor-mediated Trk receptor signaling

    5/13        Reactome Pathways for SHC3 (see all 13)
        SHC-related events
    Signalling to RAS
    IGF1R signaling cascade
    NGF signalling via TRKA from the plasma membrane
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)

    1 PharmGKB Pathway for SHC3
        EGFR Inhibitor Pathway, Pharmacodynamics

    5/9         Kegg Pathways  (Kegg details for SHC3) (see all 9):
        ErbB signaling pathway
    Chemokine signaling pathway
    Focal adhesion
    Natural killer cell mediated cytotoxicity
    Neurotrophin signaling pathway


    SHC3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SHC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for SHC3 (Q925291, 2, 3 ENSP000003649954) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046262, 3, ENSP000002695714MINT-74742 MINT-74743 I2D: score=2 STRING: ENSP00000269571
    APPP050671, 3, ENSP000002849814EBI-79084,EBI-77613 I2D: score=4 STRING: ENSP00000284981
    ERBB3P218602, 3, ENSP000002671014MINT-74745 MINT-74744 I2D: score=2 STRING: ENSP00000267101
    EGFRP005332, 3, ENSP000002754934MINT-74741 I2D: score=4 STRING: ENSP00000275493
    SH3GL3Q999632, 3, ENSP000003913724MINT-8270693 I2D: score=2 STRING: ENSP00000391372
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway TAS8808684
    GO:0007173epidermal growth factor receptor signaling pathway TAS8808684
    GO:0007265Ras protein signal transduction TAS--
    GO:0007417central nervous system development TAS8808684
    GO:0007611learning or memory IEA--


    SHC3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SHC3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SHC3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SHC3
    2 Novoseek chemical compound relationships for SHC3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphotyrosine 75.2 2 8662772 (1), 8808684 (1)
    tyrosine 61.4 5 8610109 (1), 11791173 (1), 9507002 (1), 15735675 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about SHC3 

    Transcripts
    for SHC3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SHC3 gene: 
    NM_016848.5  

    Unigene Cluster for SHC3:

    SHC (Src homology 2 domain containing) transforming protein 3
    Hs.292737  [show with all ESTs]
    Unigene Representative Sequence: NM_016848
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375835(uc004aqf.2) ENST00000375831 ENST00000375830

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SHC3
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SHC3
    8/96 QIAGEN miScript miRNA Assays for microRNAs that regulate SHC3 (see all 96):
    hsa-miR-549 hsa-miR-3194-5p hsa-miR-631 hsa-miR-519a hsa-miR-550a* hsa-miR-3116 hsa-miR-130b hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmid: SHC3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SHC3 (see all 7)
    OriGene shRNA RFP: SHC3
    OriGene siRNA: SHC3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SHC3
    Clone
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    Primer
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    Additional cDNA sequence: 

    AK127258.1 AK129921.1 BC026314.1 BC042431.1 BX538228.1 BX641139.1 D84361.1 

    6 DOTS entries:

    DT.97766224  DT.311928  DT.101963669  DT.40297564  DT.92418322  DT.95266049 

    24/41 AceView cDNA sequences (see all 41):

    BF940521 N92201 BF195644 AA725165 BX117015 BM805542 AI470442 D84361 
    BX098090 BC026314 BI524301 BU754118 BE046017 AW294374 BX641139 AW291451 
    AI457726 NM_016848 CK000348 AL133954 N53508 AI915149 AI609924 N64471 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SHC3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b
    SP1:              -     -     -                 -                                                           -               
    SP2:                                                                                            -           -               
    SP3:                                                                                                                        
    SP4:                                                                                                                        


    ECgene alternative splicing isoforms for SHC3

    Expression
    for SHC3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SHC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAGTCTGCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SHC3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainHypothalamusBrain
    BrainMedulla OblongataBrain
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See SHC3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SHC3

    SOURCE GeneReport for Unigene cluster: Hs.292737

    UniProtKB/Swiss-Prot: SHC3_HUMAN, Q92529
    Tissue specificity: Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed
    in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala.
    Expressed at low level in the cerebellum, medulla and spinal cord

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHC3

    Orthologs
    for SHC3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SHC3 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SHC31 SHC (Src homology 2 domain containing) transforming more 69.83(n)
    71.36(a)    		   431265  XM_428819.2  XP_428819.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SHC36
    		 --
    		 74(a)
    		 1 ↔ 1
    		 2(36934462-36965869)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003321111 SHC-transforming protein 3-like 66.01(n)
    64.46(a)    		   100332111  XM_002665837.2  XP_002665883.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Shc1 , 3 EGF receptor signaling pathway3
    SHC-adaptor protein1    		 34(a)3
    51.03(n)1
    46.36(a)1    		   3 67B43
    440521  NM_079944.21  NP_524683.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea shc-16
    		 SHC (Src Homology domain C-terminal) adaptor homol...
    		 27(a)
    		 1 → many
    		 I(969683-973140)


    ENSEMBL Gene Tree for SHC3 (if available)
    TreeFam Gene Tree for SHC3 (if available) 

    Paralogs
    for SHC3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SHC3 gene
    SHC42  SHC12  SHC22  
    9 SIMAP similar genes for SHC3 using alignment to 2 protein entries:     SHC3_HUMAN (see all proteins):
    BCAR3    SH2D3C    CRK    FER    SHC1    SHC4
    SHC2    SH2B2    GRB14

    SHC3 for paralogs           About GeneDecksing



    Genomic Variants
    for SHC3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2917 NCBI SNPs in SHC3 are shown (see all 2917)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs48770511,2
    		C,F,H,--61535423(+) tctacA/Gtacta 1 -- ds500118Minor allele frequency- G:0.07NS EA NA CSA 1986
    rs755156601,2
    		--61535479(+) TTCATT/CTGATT 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs754019031,2
    		F,--61535766(+) AAATGT/CTTTAC 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs796165611,2
    		F,--61536201(+) CACCTG/ACAAGG 1 -- int11Minor allele frequency- A:0.03NA 120
    rs793584051,2
    		--61536223(+) ATGCTG/AGTTTA 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1167178311,2
    		C,F,--61536309(+) TTAGAC/TGGTGC 1 -- int11Minor allele frequency- T:0.03WA 118
    rs736547251,2
    		C,F,--61536395(+) GCCTGT/CCCATT 1 -- int13Minor allele frequency- C:0.14WA 122
    rs771957041,2
    		C,--61536450(+) ATCTTA/TGTCCT 1 -- int12Minor allele frequency- T:0.13CSA WA 120
    rs1125630191,2
    		--61536522(+) ACTGAT/CAGAAT 1 -- int12Minor allele frequency- C:0.08CSA WA 120
    rs1121476191,2
    		C,--61536655(+) TGCAAC/TGCTGA 1 -- int12Minor allele frequency- T:0.04CSA WA 120

    HapMap Linkage Disequilibrium report for SHC3 (91620686 - 91793682 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for SHC3
         5 CNVs: 96190 65449 59539 83102 100704

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    Disorders / Diseases
    for SHC3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SHC3 for disorders           About GeneDecksing

    OMIM gene information: 605263    OMIM disorders: --

    17 diseases for SHC3:    About MalaCards
    nicotine dependence    neuronitis    differentiating neuroblastoma    sclerosing hepatic carcinoma
    chronic myeloid leukemia    myeloid leukemia    multiple myeloma    ependymoma
    myeloma    hepatocellular carcinoma    neuroblastoma    leukemia
    astrocytoma    hepatitis    carcinoma    cerebritis
    thyroiditis

    1 disease from the University of Copenhagen DISEASES database for SHC3:
    Hepatocellular carcinoma

    2 Novoseek disease relationships for SHC3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma 10.6 1 15735675 (1)
    tumors 0 1 15867224 (1)

    Human Genome Epidemiology (HuGE) Navigator: SHC3 (2 documents)

    Export disorders for SHC3 gene to outside databases

    Publications
    for SHC3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SHC3 gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with SHC3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway. (PubMed id 8808684)1, 2, 3, 9 Nakamura T.... Mori N. (1996)
    2. A family of Shc related proteins with conserved PTB, CH1 and SH2 regions. (PubMed id 8760305)1, 2, 9 Pelicci G....Pelicci P.-G. (1996)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. ShcB and ShcC activation by the Trk family of receptor tyrosine kinases. (PubMed id 12006576)1, 2 Liu H.Y. and Meakin S.O. (2002)
    5. Domain-specific function of ShcC docking protein in neuroblastoma cells. (PubMed id 15735675)1, 9 Miyake I....Sakai R. (2005)
    6. N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling. (PubMed id 9507002)1, 9 Nakamura T....Mori N. (1998)
    7. A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. (PubMed id 8610109)1, 9 O'Bryan J.P....Pawson T. (1996)
    8. Two adaptor proteins differentially modulate the phosphorylation and biophysics of Kv1.3 ion channel by SRC kinase. (PubMed id 11812778)1, 9 Cook K.K. and Fadool D.A. (2002)
    9. Genetic determinants of statin-induced low-density lip oprotein cholesterol reduction: the Justification for the Use of Statins in Prev ention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial. (PubMed id 22331829)1 Chasman D.I....Ridker P.M. (2012)
    10. Rai is a new regulator of neural progenitor migration and glioblastoma invasion. (PubMed id 22311806)1 Ortensi B....Pelicci G. (2012)

    External Searches for SHC3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
    Disorders
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    Genome Databases showing SHC3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 53358 HGNC: 18181 AceView: SHC3 Ensembl:ENSG00000148082 euGenes: HUgn53358
    ECgene: SHC3 Kegg: 53358 H-InvDB: SHC3

    Other Databases showing SHC3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SHC3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SHC3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SHC3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SHC3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SHC3 gene:
    Search GeneIP for patents involving SHC3

    GeneCards and IP:
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