Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SHC2 Gene

Aliases for SHC2 Gene

  • SHC (Src Homology 2 Domain Containing) Transforming Protein 2 2 3 5
  • Src Homology 2 Domain-Containing-Transforming Protein C2 3 4
  • Neuronal Shc Adaptor Homolog 2 3
  • SHC-Transforming Protein B 3 4
  • SH2 Domain Protein C2 3 4
  • Protein Sck 3 4
  • SHCB 3 4
  • SCK 3 4
  • SLI 3

External Ids for SHC2 Gene

Previous GeneCards Identifiers for SHC2 Gene

  • GC19U900043
  • GC19M000369
  • GC19M000186

Summaries for SHC2 Gene

GeneCards Summary for SHC2 Gene

SHC2 (SHC (Src Homology 2 Domain Containing) Transforming Protein 2) is a Protein Coding gene. Among its related pathways are Bacterial invasion of epithelial cells and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include protein kinase binding and receptor tyrosine kinase binding. An important paralog of this gene is SHC1.

UniProtKB/Swiss-Prot for SHC2 Gene

  • Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).

Gene Wiki entry for SHC2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHC2 Gene

Genomics for SHC2 Gene

Regulatory Elements for SHC2 Gene

Enhancers for SHC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SHC2 on UCSC Golden Path with GeneCards custom track

Promoters for SHC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SHC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SHC2 Gene

416,583 bp from pter
461,024 bp from pter
44,442 bases
Minus strand

Genomic View for SHC2 Gene

Genes around SHC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHC2 Gene

Proteins for SHC2 Gene

  • Protein details for SHC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SHC-transforming protein 2
    Protein Accession:
    Secondary Accessions:
    • O60230
    • Q9NPL5
    • Q9UCX4

    Protein attributes for SHC2 Gene

    582 amino acids
    Molecular mass:
    61916 Da
    Quaternary structure:
    • Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2.
    • PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576.

neXtProt entry for SHC2 Gene

Proteomics data for SHC2 Gene at MOPED

Post-translational modifications for SHC2 Gene

Other Protein References for SHC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHC2 Gene

Domains & Families for SHC2 Gene

Gene Families for SHC2 Gene

Suggested Antigen Peptide Sequences for SHC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The PID domain mediates binding to the TrkA receptor.
  • The PID domain mediates binding to the TrkA receptor.
  • Contains 1 PID domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SHC2: view

Function for SHC2 Gene

Molecular function for SHC2 Gene

UniProtKB/Swiss-Prot Function:
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).
genes like me logo Genes that share phenotypes with SHC2: view

Animal Models for SHC2 Gene

MGI Knock Outs for SHC2:

Animal Model Products

miRNA for SHC2 Gene

miRTarBase miRNAs that target SHC2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SHC2 Gene

Localization for SHC2 Gene

Subcellular locations from

Jensen Localization Image for SHC2 Gene COMPARTMENTS Subcellular localization image for SHC2 gene
Compartment Confidence
cytosol 5
plasma membrane 3
extracellular 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SHC2 Gene

Pathways & Interactions for SHC2 Gene

SuperPathways for SHC2 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 ErbB signaling pathway
3 Developmental Biology
4 Immune System
5 Signaling by GPCR
genes like me logo Genes that share pathways with SHC2: view

SIGNOR curated interactions for SHC2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SHC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007411 axon guidance TAS --
GO:0008286 insulin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with SHC2: view

Drugs & Compounds for SHC2 Gene

(1) Drugs for SHC2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for SHC2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SHC2: view

Transcripts for SHC2 Gene

Unigene Clusters for SHC2 Gene

SHC (Src homology 2 domain containing) transforming protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SHC2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b
SP1: - - - -
SP2: - -
SP3: -
SP4: - - -
SP5: - -
SP6: -
SP7: -

Relevant External Links for SHC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SHC2 Gene

mRNA expression in normal human tissues for SHC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SHC2 Gene

This gene is overexpressed in Pancreas (x5.9).

Protein differential expression in normal tissues from HIPED for SHC2 Gene

This gene is overexpressed in Monocytes (54.8) and Fetal ovary (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SHC2 Gene

SOURCE GeneReport for Unigene cluster for SHC2 Gene Hs.30965

mRNA Expression by UniProt/SwissProt for SHC2 Gene

Tissue specificity: Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.
genes like me logo Genes that share expression patterns with SHC2: view

Protein tissue co-expression partners for SHC2 Gene

Primer Products

Orthologs for SHC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SHC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC533455 35
  • 87.11 (n)
  • 88.92 (a)
SHC2 36
  • 82 (a)
(Canis familiaris)
Mammalia LOC611955 35
  • 87.74 (n)
  • 89.62 (a)
(Mus musculus)
Mammalia Shc2 35
  • 82.92 (n)
  • 87.32 (a)
Shc2 16
Shc2 36
  • 86 (a)
(Rattus norvegicus)
Mammalia Shc2 35
  • 83.39 (n)
  • 88.57 (a)
(Ornithorhynchus anatinus)
Mammalia SHC2 36
  • 73 (a)
(Pan troglodytes)
Mammalia SHC2 36
  • 96 (a)
(Gallus gallus)
Aves SHC2 35
  • 73.39 (n)
  • 72.11 (a)
SHC2 36
  • 68 (a)
(Anolis carolinensis)
Reptilia SHC2 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia shc2 35
  • 64.57 (n)
  • 70.61 (a)
(Danio rerio)
Actinopterygii shc2 35
  • 69.12 (n)
  • 72.1 (a)
shc2 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta Shc 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea shc-1 36
  • 28 (a)
Species with no ortholog for SHC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SHC2 Gene

Gene Tree for SHC2 (if available)
Gene Tree for SHC2 (if available)

Paralogs for SHC2 Gene

Paralogs for SHC2 Gene

(3) SIMAP similar genes for SHC2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SHC2: view

Variants for SHC2 Gene

Sequence variations from dbSNP and Humsavar for SHC2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7256741 -- 453,898(+) AGGAC(A/G)GCCTG intron-variant
rs7257230 -- 454,351(+) AGGAG(A/C)CCCAC intron-variant
rs7257878 -- 429,139(+) GATGA(C/T)GCAGT intron-variant
rs7259509 -- 453,826(+) GAGCC(A/G)GACAC intron-variant
rs12975844 -- 421,437(+) agaga(A/G)aaaaa intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SHC2 Gene

Variant ID Type Subtype PubMed ID
nsv428360 CNV Gain 18775914
dgv3498n71 CNV Loss 21882294
nsv910083 CNV Loss 21882294
dgv3499n71 CNV Loss 21882294
dgv3500n71 CNV Loss 21882294
dgv3501n71 CNV Gain 21882294
dgv3502n71 CNV Loss 21882294
dgv3503n71 CNV Loss 21882294
dgv3504n71 CNV Loss 21882294
dgv3505n71 CNV Loss 21882294
nsv910102 CNV Loss 21882294
nsv817810 CNV Loss 17921354
nsv910109 CNV Loss 21882294
nsv509712 CNV Insertion 20534489
esv2671474 CNV Deletion 23128226
nsv470101 CNV Loss 18288195
nsv910112 CNV Loss 21882294
esv2497793 CNV Deletion 19546169
esv1994729 CNV Deletion 18987734
esv26032 CNV Loss 19812545
esv3494 CNV Deletion 18987735
nsv828348 CNV Loss 20364138
esv2661854 CNV Deletion 23128226
esv5410 CNV Deletion 18987735
esv25497 CNV Gain+Loss 19812545
esv2663200 CNV Deletion 23128226
nsv2384 CNV Insertion 18451855
nsv820768 CNV Deletion 20802225
nsv433453 CNV Gain 18776910
esv1627441 CNV Deletion 17803354
nsv514895 CNV Complex 21397061
esv1499855 CNV Insertion 17803354
esv2276998 CNV Deletion 18987734
esv2659523 CNV Deletion 23128226
dgv3506n71 CNV Loss 21882294
dgv3507n71 CNV Loss 21882294
esv2323487 CNV Deletion 18987734
esv4763 CNV Deletion 18987735
esv1557758 CNV Deletion 17803354
nsv138298 CNV Loss 16902084
nsv910117 CNV Gain 21882294
nsv910119 CNV Gain 21882294
dgv3508n71 CNV Loss 21882294
dgv3509n71 CNV Loss 21882294
esv2223344 CNV Deletion 18987734
esv28823 CNV Loss 19812545
esv2669304 CNV Deletion 23128226
esv2659245 CNV Deletion 23128226
esv23197 CNV Gain 19812545
esv2676066 CNV Deletion 23128226
esv2672865 CNV Deletion 23128226

Variation tolerance for SHC2 Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.06; 60.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SHC2 Gene

Disorders for SHC2 Gene

Relevant External Links for SHC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SHC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHC2 Gene

Publications for SHC2 Gene

  1. N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling. (PMID: 9507002) Nakamura T. … Mori N. (J. Biol. Chem. 1998) 2 3 4 67
  2. The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells. (PMID: 10749680) Warner A.J. … Prigent S.A. (Biochem. J. 2000) 3 23
  3. A family of Shc related proteins with conserved PTB, CH1 and SH2 regions. (PMID: 8760305) Pelicci G. … Pelicci P.-G. (Oncogene 1996) 3 23
  4. An alternative to SH2 domains for binding tyrosine-phosphorylated proteins. (PMID: 7527937) Kavanaugh W.M. … Williams L.T. (Science 1994) 2 3
  5. CD95 promotes metastatic spread via Sck in pancreatic ductal adenocarcinoma. (PMID: 25613377) Teodorczyk M. … Martin-Villalba A. (Cell Death Differ. 2015) 3

Products for SHC2 Gene

Sources for SHC2 Gene