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SHC2 Gene

protein-coding   GIFtS: 57
GCID: GC19M000420

SHC (Src Homology 2 Domain Containing) Transforming Protein...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SHC (Src Homology 2 Domain Containing) Transforming Protein 21 2     Src Homology 2 Domain-Containing-Transforming Protein C22 3
SCK2 3 5     SH2 Domain Protein C22 3
SHCB2 3 5     SHC-Transforming Protein B2 3
Neuronal Shc Adaptor Homolog1 2     SLI2
Protein Sck2 3     SHC-Transforming Protein 22

External Ids:    HGNC: 298691   Entrez Gene: 257592   Ensembl: ENSG000001299467   OMIM: 6052175   UniProtKB: P980773   

Export aliases for SHC2 gene to outside databases

Previous GC identifers: GC19U900043 GC19M000369 GC19M000186


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SHC2 Gene:
SHC2 (SHC (Src homology 2 domain containing) transforming protein 2) is a protein-coding gene. An important paralog of this gene is SHC4.

UniProtKB/Swiss-Prot: SHC2_HUMAN, P98077
Function: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons.
Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By
similarity)

Gene Wiki entry for SHC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SHC2 gene promoter:
         p53   SRF (504 AA)   STAT5A   PPAR-gamma1   E2F   E2F-1   COMP1   PPAR-gamma2   Pax-4a   ATF6   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SHC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SHC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

SHC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHC2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M000420:  view genomic region     (about GC identifiers)

Start:
416,583 bp from pter      End:
460,996 bp from pter
Size:
44,414 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SHC2_HUMAN, P98077 (See protein sequence)
Recommended Name: SHC-transforming protein 2  
Size: 582 amino acids; 61916 Da
Subunit: Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds
to GRB2
Miscellaneous: PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to
PubMed:12006576
Secondary accessions: O60230 Q9NPL5 Q9UCX4

Explore the universe of human proteins at neXtProt for SHC2: NX_P98077

Explore proteomics data for SHC2 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosines by the Trk receptors1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SHC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036567.2  
    ENSEMBL proteins: 
     ENSP00000264554   ENSP00000465764   ENSP00000466869   ENSP00000476217   ENSP00000475250  
    Reactome Protein details: P98077

    SHC2 Human Recombinant Protein Products:

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    Novus Biologicals SHC2 Protein
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SHC2

     
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    antibodies-online proteins for SHC2 (6 products) 

     
    antibodies-online peptides for SHC2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    4 InterPro protein domains:
     IPR011993 PH_like_dom
     IPR006020 PTB/PI_dom
     IPR006019 PID_Shc-like
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry P98077

    ProtoNet protein and cluster: P98077

    2 Blocks protein domains:
    IPB006019 SHC phosphotyrosine interaction domain signature
    IPB006020 Phosphotyrosine interaction domain


    UniProtKB/Swiss-Prot: SHC2_HUMAN, P98077
    Domain: The PID domain mediates binding to the TrkA receptor
    Similarity: Contains 1 PID domain
    Similarity: Contains 1 SH2 domain


    Find genes that share domains with SHC2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SHC2_HUMAN, P98077
    Function: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons.
    Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By
    similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16273093
         
    Find genes that share ontologies with SHC2           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Shc2):
     nervous system 

    Find genes that share phenotypes with SHC2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SHC2

    miRNA
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    miRTarBase miRNAs that target SHC2:
    hsa-mir-26a-5p (MIRT050116), hsa-mir-186-5p (MIRT044976)

    Block miRNA regulation of human, mouse, rat SHC2 using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with SHC2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SHC2 About   (see all 23)  
    See pathways by source

    SuperPathContained pathways About
    1ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    ErbB signaling pathway0.52
    2Insulin receptor signalling cascade
    Insulin receptor signalling cascade0.94
    SHC-related events0.00
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    SHC-mediated signalling0.00
    IGF1R signaling cascade0.92
    SHC-related events triggered by IGF1R0.00
    Signaling by Insulin receptor0.80
    Signal attenuation0.00
    3Signalling to ERKs
    Signalling to ERKs0.73
    Signalling to RAS0.73
    4Signaling by FGFR
    NGF signalling via TRKA from the plasma membrane0.71
    Signalling by NGF0.71
    5Signaling events mediated by VEGFR1 and VEGFR2
    Signaling events mediated by VEGFR1 and VEGFR20.37
    VEGFR1 specific signals0.37


    Find genes that share SuperPaths with SHC2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SHC2
        VEGF Pathway

    1 GeneGo (Thomson Reuters) Pathway for SHC2
        Development VEGF signaling via VEGFR2 - generic cascades

    Selected BioSystems Pathways for SHC2 (see all 7)
        Insulin Signaling
    ErbB signaling pathway
    BDNF signaling pathway
    IL-5 Signaling Pathway
    VEGFR1 specific signals

    3 Reactome Pathways for SHC2
        SHC-mediated signalling
    Signal attenuation
    Signalling to RAS

    1 PharmGKB Pathway for SHC2
        EGFR Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for SHC2) (see all 14):
        ErbB signaling pathway
    Ras signaling pathway
    Chemokine signaling pathway
    VEGF signaling pathway
    Focal adhesion

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SHC2: 
              VEGF Signaling in human mouse rat
              Focal Adhesions in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SHC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SHC2 (P980771, 2, 3 ENSP000002645544) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046261, 2, 3, ENSP000002695714EBI-7256023,EBI-641062 MINT-74526 MINT-74527 MINT-74525 I2D: score=1 STRING: ENSP00000269571
    EGFRP005331, 2, 3, ENSP000002754934EBI-7256023,EBI-297353 MINT-74524 MINT-74523 MINT-74522 I2D: score=1 STRING: ENSP00000275493
    KDRP359682, 3, ENSP000002639234MINT-8036302 MINT-8036317 I2D: score=4 STRING: ENSP00000263923
    ARHGAP32A7KAX93, ENSP000003105614STRING: ENSP00000310561 I2D: score=1 
    FLT1P179483, ENSP000002823974I2D: score=1 STRING: ENSP00000282397
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007265Ras protein signal transduction TAS--
    GO:0008286insulin receptor signaling pathway TAS--
    GO:0048011neurotrophin TRK receptor signaling pathway TAS--

    Find genes that share ontologies with SHC2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SHC2

    3 Novoseek inferred chemical compound relationships for SHC2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphotyrosine 70.8 1 12214271 (1)
    tyrosine 47.9 3 12214271 (2)
    vegf 38.7 8 12214271 (3), 10749680 (1)



    Find genes that share compounds with SHC2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SHC2 gene: 
    NM_012435.2  

    Unigene Cluster for SHC2:

    SHC (Src homology 2 domain containing) transforming protein 2
    Hs.30965  [show with all ESTs]
    Unigene Representative Sequence: AK128825
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587423 ENST00000588376 ENST00000264554(uc002loq.4) ENST00000589922
    ENST00000590170 ENST00000590222 ENST00000591388 ENST00000590113
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Additional mRNA sequence: 

    AB001451.1 AK128825.1 AL360254.1 BC030527.1 BC034544.1 BC048290.1 

    8 DOTS entries:

    DT.312194  DT.91992278  DT.91826980  DT.95133289  DT.100001281  DT.100654834  DT.101971311  DT.86840701 

    Selected AceView cDNA sequences (see all 92):

    BQ023339 BI771193 BU754380 CR617776 AI203569 AL134433 BQ706594 AI382451 
    CB851079 AI272312 CF457169 AI597914 AW072558 BE041631 AI363366 AL360254 
    BM833137 BX419515 BM712819 BG910554 BI757280 AI139739 T05885 BU742483 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SHC2 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b
    SP1:              -           -                       -                                   -                                                         
    SP2:              -                                   -                                                                                             
    SP3:                                                                                      -                                                         
    SP4:                                                                                      -                 -     -                                 
    SP5:                                                                                      -                 -                                       


    ECgene alternative splicing isoforms for SHC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SHC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCGCTGA
    SHC2 Expression
    About this image


    SHC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Heart (Cardiovascular System)
    SHC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SHC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.30965

    UniProtKB/Swiss-Prot: SHC2_HUMAN, P98077
    Tissue specificity: Expressed in brain. Expressed at high level in the hypothalamus and at low level in the
    caudate nucleus

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SHC2: 
              VEGF Signaling in human mouse rat
              Focal Adhesions in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for SHC2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Shc21 , 5 SHC (Src homology 2 domain containing) transforming more1, 5 82.92(n)1
    87.32(a)1
      10 (39.72 cM)5
    2161481  NM_001024539.11  NP_001019710.11 
     796180515 
    chicken
    (Gallus gallus)
    Aves SHC21 SHC (Src homology 2 domain containing) transforming more 73.39(n)
    72.11(a)
      770341  XM_001233681.3  XP_001233682.3 
    lizard
    (Anolis carolinensis)
    Reptilia SHC26
    SHC (Src homology 2 domain containing) transformin...
    65(a)
    1 ↔ 1
    GL344253.1(6987-18764)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia shc21 SHC (Src homology 2 domain containing) transforming more 64.57(n)
    70.61(a)
      100487416  XM_002939766.2  XP_002939812.2 
    zebrafish
    (Danio rerio)
    Actinopterygii shc21 SHC (Src homology 2 domain containing) transforming more 69.12(n)
    72.1(a)
      562011  NM_001044973.1  NP_001038438.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Shc6
    SHC-adaptor protein
    38(a)
    1 → many
    3L(9420110-9421771)
    worm
    (Caenorhabditis elegans)
    Secernentea shc-16
    Protein SHC-1, isoform a
    28(a)
    1 → many
    I(969680-973137) WBGene00018788


    ENSEMBL Gene Tree for SHC2 (if available)
    TreeFam Gene Tree for SHC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for SHC2 gene
    SHC42  SHC12  SHC32  
    3 SIMAP similar genes for SHC2 using alignment to 5 protein entries:     SHC2_HUMAN (see all proteins):
    SHC4    SHC1    SHC3

    Find genes that share paralogs with SHC2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SHC2 (see all 1745)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs777774411,2
    C--416123(+) CTGGGC/TGTCGG 1 -- int10--------
    rs1875253801,2
    --416178(+) GACAAC/TAGGAA 1 -- int10--------
    rs1411628631,2
    --416188(+) AAGCCC/TGGCCC 1 -- int10--------
    rs756854261,2
    C--416205(+) GGCCAT/CGCTGG 1 -- int14Minor allele frequency- C:0.07CSA WA NA EA 359
    rs169904261,2
    C,F,H--416231(+) GAAAAC/TAACCA 1 -- int121Minor allele frequency- T:0.18NA NS EA WA CSA 2464
    rs1923851981,2
    --416254(+) TGTCCC/TGGGCT 1 -- int10--------
    rs1857524241,2
    --416406(+) GCAGAA/GGGGTC 1 -- int10--------
    rs9298341,2
    C,F,H--416449(-) AGGCGG/AGGCTG 1 -- int17Minor allele frequency- A:0.14NS EA WA CSA 542
    rs1390262701,2
    --416511(+) GCCCCA/CTCATC 1 -- int10--------
    rs37521561,2
    H--416538(+) GACTCG/ATCCCA 1 -- int14Minor allele frequency- A:0.00NS EA 412

    HapMap Linkage Disequilibrium report for SHC2 (416583 - 460996 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SHC2 (see all 51):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1557758CNV Deletion17803354
    esv2669304CNV Deletion23128226
    nsv820768CNV Deletion20802225
    esv4763CNV Deletion18987735
    esv1627441CNV Deletion17803354
    esv2661854CNV Deletion23128226
    esv5410CNV Deletion18987735
    esv3494CNV Deletion18987735
    esv2659523CNV Deletion23128226
    esv2223344CNV Deletion18987734

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SHC2
    DNA2.0 Custom Variant and Variant Library Synthesis for SHC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605217    OMIM disorders: --


    Find genes that share disorders with SHC2           About GenesLikeMe


    Export disorders for SHC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SHC2 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with SHC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling. (PubMed id 9507002)1, 2, 3 Nakamura T.... Mori N. (J. Biol. Chem. 1998)
    2. An alternative to SH2 domains for binding tyrosine-phosphorylated proteins. (PubMed id 7527937)1, 2, 3 Kavanaugh W.M. and Williams L.T. (Science 1994)
    3. A family of Shc related proteins with conserved PTB, CH1 and SH2 regions. (PubMed id 8760305)1, 2, 9 Pelicci G....Pelicci P.-G. (Oncogene 1996)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    5. ShcB and ShcC activation by the Trk family of receptor tyrosine kinases. (PubMed id 12006576)1, 2 Liu H.Y. and Meakin S.O. (J. Biol. Chem. 2002)
    6. The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells. (PubMed id 10749680)1, 9 Warner A.J....Prigent S.A. (Biochem. J. 2000)
    7. Copy number loss of (src homology 2 domain containing)-transforming protein 2 (SHC2) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy. (PubMed id 21658278)1 Sasaki H....Matsubara K. (Mol Brain 2011)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    9. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PubMed id 16368877)1 Choy K.W....Pang C.P. (Physiol. Genomics 2006)
    10. A quantitative protein interaction network for the ErbB receptors using protein microarrays. (PubMed id 16273093)1 Jones R.B....MacBeath G. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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      Query String
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25759 HGNC: 29869 AceView: SHC2 Ensembl:ENSG00000129946 euGenes: HUgn25759
    ECgene: SHC2 Kegg: 25759 H-InvDB: SHC2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SHC2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SHC2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SHC2 gene:
    Search GeneIP for patents involving SHC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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