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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SHC2 Gene

protein-coding   GIFtS: 57
GCID: GC19M000369

SHC (Src homology 2 domain containing) transforming protein...
 Explore 10 diseases affiliated with
SHC2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SHC2    

Aliases
for SHC2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SHC (Src Homology 2 Domain Containing) Transforming Protein 21 2     Src Homology 2 Domain-Containing-Transforming Protein C22 3
SCK1 2 3     SH2 Domain Protein C22 3
SHCB1 2 3     SHC-Transforming Protein B2 3
SLI1 2     Neuronal Shc Adaptor Homolog2
Protein Sck2 3     SHC-Transforming Protein 22

External Ids:    HGNC: 298691   Entrez Gene: 257592   Ensembl: ENSG000001299467   OMIM: 6052175   UniProtKB: P980773   

Export aliases for SHC2 gene to outside databases

Previous GC identifers: GC19U900043 GC19M000186


Summaries
for SHC2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SHC2_HUMAN, P98077
Function: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in
the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity)

Gene Wiki entry for SHC2


Genomic Views
for SHC2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SHC2 gene promoter:
         p53   SRF (504 AA)   STAT5A   PPAR-gamma1   E2F   E2F-1   COMP1   PPAR-gamma2   Pax-4a   ATF6   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SHC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

SHC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHC2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M000369:  view genomic region     (about GC identifiers)

Start:
 416,583 bp from pter      End:
 460,996 bp from pter
Size:
 44,414 bases      Orientation:
 minus strand

Proteins
for SHC2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SHC2_HUMAN, P98077 (See protein sequence)
Recommended Name: SHC-transforming protein 2  
Size: 582 amino acids; 61916 Da
Subunit: Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to
GRB2
Miscellaneous: PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to
PubMed:12006576
Secondary accessions: O60230 Q9NPL5 Q9UCX4

Explore the universe of human proteins at neXtProt for SHC2: NX_P98077

Post-translational modifications:

  • Phosphorylated on tyrosines by the Trk receptors1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P98077

    • SHC2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036567.2  
    ENSEMBL proteins: 
     ENSP00000264554   ENSP00000465764   ENSP00000466869  
    Reactome Protein details: P98077
    Human Recombinant Protein Products: 
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    Novus Biologicals SHC2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SHC2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005829cytosol TAS--


    SHC2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SHC2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SHC2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR006020 PTyr_interaction_dom
     IPR006019 PID_domain
     IPR000980 SH2
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry P98077

    ProtoNet protein and cluster: P98077

    2 Blocks protein families:
    IPB006019 SHC phosphotyrosine interaction domain signature
    IPB006020 Phosphotyrosine interaction domain


    UniProtKB/Swiss-Prot: SHC2_HUMAN, P98077
    Domain: The PID domain mediates binding to the TrkA receptor
    Similarity: Contains 1 PID domain
    Similarity: Contains 1 SH2 domain


    Function
    for SHC2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SHC2_HUMAN, P98077
    Function: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in
    the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity)

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: SHC2
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for SHC2

    In Situ Assay
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    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Shc2):
     nervous system 

    SHC2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SHC2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/21 super-pathways (see all 21) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1IRS-related events
    		Insulin receptor signalling cascade0.94
    		IGF1R signaling cascade0.90
    		Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.90
    		Signaling by Insulin receptor0.74
    2SHC-mediated signalling
    		SHC-mediated signalling1.00
    		SHC-related events triggered by IGF1R0.83
    		SHC-related events0.88
    3ErbB signaling pathway
    		ErbB signaling pathway1.00
    		EGFR Inhibitor Pathway, Pharmacodynamics0.50
    		ErbB signaling pathway0.51
    4Signalling to RAS
    		Signalling to RAS1.00
    		Signalling to ERKs0.73
    5Signaling events mediated by VEGFR1 and VEGFR2
    		Signaling events mediated by VEGFR1 and VEGFR21.00
    		VEGFR1 specific signals0.37

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for SHC2
        Development VEGF signaling via VEGFR2 - generic cascades

    5/6 BioSystems Pathways for SHC2 (see all 6) 
        ErbB signaling pathway
    IL-5 Signaling Pathway
    Insulin Signaling
    VEGFR1 specific signals
    Signaling events mediated by VEGFR1 and VEGFR2

    5/13        Reactome Pathways for SHC2 (see all 13)
        SHC-related events
    Signalling to RAS
    IGF1R signaling cascade
    NGF signalling via TRKA from the plasma membrane
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)

    1 PharmGKB Pathway for SHC2
        EGFR Inhibitor Pathway, Pharmacodynamics

    5/10         Kegg Pathways  (Kegg details for SHC2) (see all 10):
        ErbB signaling pathway
    Chemokine signaling pathway
    VEGF signaling pathway
    Focal adhesion
    Natural killer cell mediated cytotoxicity


    SHC2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SHC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/51 Interacting proteins for SHC2 (P980772, 3 ENSP000002645544) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046262, 3, ENSP000002695714MINT-74526 MINT-74527 MINT-74525 I2D: score=1 STRING: ENSP00000269571
    EGFRP005332, 3, ENSP000002754934MINT-74524 MINT-74523 MINT-74522 I2D: score=1 STRING: ENSP00000275493
    KDRP359682, 3, ENSP000002639234MINT-8036302 MINT-8036317 I2D: score=4 STRING: ENSP00000263923
    ARHGAP32A7KAX93, ENSP000003105614STRING: ENSP00000310561 I2D: score=1 
    FLT1P179483, ENSP000002823974I2D: score=1 STRING: ENSP00000282397
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007265Ras protein signal transduction TAS--
    GO:0008286insulin receptor signaling pathway TAS--
    GO:0048011nerve growth factor receptor signaling pathway TAS--


    SHC2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SHC2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SHC2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SHC2
    3 Novoseek chemical compound relationships for SHC2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphotyrosine 70.8 1 12214271 (1)
    tyrosine 47.9 3 12214271 (2)
    vegf 38.7 8 12214271 (3), 10749680 (1)

    Search CenterWatch for drugs/clinical trials and news about SHC2 

    Transcripts
    for SHC2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SHC2 gene: 
    NM_012435.2  

    Unigene Cluster for SHC2:

    SHC (Src homology 2 domain containing) transforming protein 2
    Hs.30965  [show with all ESTs]
    Unigene Representative Sequence: AK128825
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587423 ENST00000588376 ENST00000264554(uc002loq.4) ENST00000589922
    ENST00000590170 ENST00000591948 ENST00000590222 ENST00000591388 ENST00000590113


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SHC2
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    hsa-miR-483-3p hsa-miR-9 hsa-miR-508-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SHC2 (see all 7)
    OriGene shRNA RFP: SHC2
    OriGene siRNA: SHC2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SHC2
    Clone
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    Additional cDNA sequence: 

    AB001451.1 AK128825.1 AL360254.1 BC030527.1 BC034544.1 BC048290.1 

    8 DOTS entries:

    DT.312194  DT.91992278  DT.91826980  DT.95133289  DT.100001281  DT.100654834  DT.101971311  DT.86840701 

    24/92 AceView cDNA sequences (see all 92):

    BU754380 AI203569 AL134433 CR617776 BI771193 BQ023339 AI749640 AI701569 
    BM833137 BI767528 AI610716 AI472104 BQ953619 BM547217 BE790870 AI139739 
    AI127307 AW135544 BC048290 CB851079 AB001451 AI418693 BX440420 AI363366 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SHC2 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b
    SP1:              -           -                       -                                   -                                                         
    SP2:              -                                   -                                                                                             
    SP3:                                                                                      -                                                         
    SP4:                                                                                      -                 -     -                                 
    SP5:                                                                                      -                 -                                       


    ECgene alternative splicing isoforms for SHC2

    Expression
    for SHC2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SHC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGGCGCTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SHC2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeRetinaEye
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SHC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SHC2

    SOURCE GeneReport for Unigene cluster: Hs.30965

    UniProtKB/Swiss-Prot: SHC2_HUMAN, P98077
    Tissue specificity: Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate
    nucleus

        SABiosciences Expression via Pathway-Focused PCR Arrays including SHC2: 
              VEGF Signaling in human mouse rat
              Focal Adhesions in human mouse rat

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    In Situ
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    Orthologs
    for SHC2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SHC2 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Shc21 , 5 SHC (Src homology 2 domain containing) transforming more1, 5 83.21(n)1
    87.86(a)1    		   10 (39.72 cM)5
    2161481  NM_001024539.11  NP_001019710.11 
     796180515 
    chicken
    (Gallus gallus)    		 Aves SHC21 SHC (Src homology 2 domain containing) transforming more 73.52(n)
    72.81(a)    		   770341  XM_001233681.2  XP_001233682.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SHC26
    		 --
    		 68(a)
    		 1 ↔ 1
    		 GL344253.1(7300-18724)
    zebrafish
    (Danio rerio)    		 Actinopterygii shc21 SHC (Src homology 2 domain containing) transforming more 69.29(n)
    72.58(a)    		   562011  NM_001044973.1  NP_001038438.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Shc6
    		 SHC-adaptor protein
    		 37(a)
    		 1 → many
    		 3L(9420110-9421771)
    worm
    (Caenorhabditis elegans)    		 Secernentea shc-16
    		 SHC (Src Homology domain C-terminal) adaptor homol...
    		 27(a)
    		 1 → many
    		 I(969683-973140)


    ENSEMBL Gene Tree for SHC2 (if available)
    TreeFam Gene Tree for SHC2 (if available) 

    Paralogs
    for SHC2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SHC2 gene
    SHC42  SHC12  SHC32  
    3 SIMAP similar genes for SHC2 using alignment to 3 protein entries:     SHC2_HUMAN (see all proteins):
    SHC3    SHC1    SHC4

    SHC2 for paralogs           About GeneDecksing



    Genomic Variants
    for SHC2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1364 NCBI SNPs in SHC2 are shown (see all 1364)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs777774411,2
    		C,--416123(+) CTGGGC/TGTCGG 1 -- int10--------
    rs1875253801,2
    		--416178(+) GACAAC/TAGGAA 1 -- int10--------
    rs1411628631,2
    		--416188(+) AAGCCC/TGGCCC 1 -- int10--------
    rs756854261,2
    		C,--416205(+) GGCCAT/CGCTGG 1 -- int14Minor allele frequency- C:0.07CSA WA NA EA 359
    rs169904261,2
    		C,F,H,--416231(+) GAAAAC/TAACCA 1 -- int121Minor allele frequency- T:0.18NA NS EA WA CSA 2464
    rs1923851981,2
    		--416254(+) TGTCCC/TGGGCT 1 -- int10--------
    rs1857524241,2
    		--416406(+) GCAGAA/GGGGTC 1 -- int10--------
    rs9298341,2
    		C,F,H,--416449(-) AGGCGG/AGGCTG 1 -- int17Minor allele frequency- A:0.14NS EA WA CSA 542
    rs1390262701,2
    		--416511(+) GCCCCA/CTCATC 1 -- int10--------
    rs37521561,2
    		H--416538(+) GACTCG/ATCCCA 1 -- int14Minor allele frequency- A:0.00NS EA 412

    HapMap Linkage Disequilibrium report for SHC2 (416583 - 460996 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 22 variations for SHC2
         13 CNVs: 73256 23564 73257 78029 37636 10540 73259 23563 30050 89030 78030 35624 102756
         9 Indels: 45764 45759 42057 42693 89031 73258 73255 45763 43077

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    Disorders / Diseases
    for SHC2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SHC2 for disorders           About GeneDecksing

    OMIM gene information: 605217    OMIM disorders: --

    10 diseases for SHC2:    About MalaCards
    duchenne muscular dystrophy    muscular dystrophy    multiple system atrophy    neuronitis
    chronic myeloid leukemia    myeloid leukemia    twinning    leukemia
    tuberculosis    carcinoma


    Export disorders for SHC2 gene to outside databases

    Publications
    for SHC2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SHC2 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with SHC2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling. (PubMed id 9507002)1, 2, 3 Nakamura T....Mori N. (1998)
    2. An alternative to SH2 domains for binding tyrosine-phosphorylated proteins. (PubMed id 7527937)1, 2, 3 Kavanaugh W.M. and Williams L.T. (1994)
    3. A family of Shc related proteins with conserved PTB, CH1 and SH2 regions. (PubMed id 8760305)1, 2, 9 Pelicci G....Pelicci P.-G. (1996)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    5. ShcB and ShcC activation by the Trk family of receptor tyrosine kinases. (PubMed id 12006576)1, 2 Liu H.Y. and Meakin S.O. (2002)
    6. The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells. (PubMed id 10749680)1, 9 Warner A.J....Prigent S.A. (2000)
    7. Copy number loss of (src homology 2 domain containing )-transforming protein 2 (SHC2) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy. (PubMed id 21658278)1 Sasaki H....Matsubara K. (2011)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    9. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PubMed id 16368877)1 Choy K.W....Pang C.P. (2006)
    10. Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation. (PubMed id 15851471)2 Nanda N.... Hart M.J. (2005)

    External Searches for SHC2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    Genome Databases showing SHC2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25759 HGNC: 29869 AceView: SHC2 Ensembl:ENSG00000129946 euGenes: HUgn25759
    ECgene: SHC2 Kegg: 25759 H-InvDB: SHC2

    Other Databases showing SHC2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SHC2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SHC2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SHC2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SHC2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SHC2 gene:
    Search GeneIP for patents involving SHC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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