SHC1 Gene
protein-coding GIFtS: 68
GCID: GC01M154934
|
|
SHC (Src homology 2 domain containing) transforming protein...(Previous name: SHC (Src homology 2 domain-containing) transforming protein...)
(Previous symbol: SHC)
| |
Aliases
for SHC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SHC (Src Homology 2 Domain Containing) Transforming Protein 11 2 | | SHC-Transforming Protein 32 3 | | SHC1 2 3 | | SHC-Transforming Protein A2 3 | | SHC (Src Homology 2 Domain-Containing) Transforming Protein 11 2 | | P661 | | SHCA2 3 | | SHC-Transforming Protein 12 | | SH2 Domain Protein C12 3 | | Src Homology 2 Domain-Containing-Transforming Protein C13 |
Export aliases for SHC1 gene to outside databasesPrevious GC identifers: GC01M152750 GC01M150665 GC01M151710 GC01M152151 GC01M151747 GC01M153201 GC01M126296 |
Summaries
for SHC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SHC1:
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapterproteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effectsof reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to theRas pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other twoisoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms havebeen found for this gene. (provided by RefSeq, Feb 2011)
UniProtKB/Swiss-Prot: SHC1_HUMAN, P29353Function: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in asignaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated,couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated inthe cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators ofthe Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but isinvolved in signal transduction pathways that regulate the cellular response to oxidative stress and life span.Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability ofstress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expressionof isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of theangiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sproutingangiogenesis
Gene Wiki entry for SHC1
|
Genomic Views
for SHC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SHC1 gene promoter:
CREB AP-1 deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for SHC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21SHC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M154934: view genomic region
(about GC identifiers)
Start:
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154,934,774 bp from pter |
End:
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154,946,959 bp from pter |
Size:
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12,186 bases |
Orientation:
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minus strand |
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Proteins
for SHC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SHC1_HUMAN, P29353 (See
protein sequence)Recommended Name: SHC-transforming protein 1 Size: 583 amino acids; 62822 Da
Subunit: Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR in vitro via the PID domain. Onceactivated, binds to GRB2. Interacts with tyrosine-phosphorylated CD3T and DDR2. Interacts with the N-terminal regionof APS. Interacts with phosphorylated LRP1 and IRS4. Interacts with INPP5D/SHIP1 and INPPL1/SHIP2. Interacts withTRIM31. Interacts with PTPN6/SHP (tyrosine phosphorylated). Identified in a complex containing FGFR4, NCAM1, CDH2,PLCG1, FRS2, SRC, SHC1, GAP43 and CTT (By similarity). Interacts with ALK, GAB2, GRB7 and KIT. Interacts with FLT4(tyrosine-phosphorylated). Interacts with EPHB1 and GRB2; activates the MAPK/ERK cascade to regulate cell migration.Interacts with PDGFRB (tyrosine-phosphorylated). Interacts with ERBB4. Interacts with TEK/TIE2(tyrosine-phosphorylated). Interacts with the Trk receptors NTRK1, NTRK2 and NTRK3; in a phosphotyrosine-dependentmanner. Interacts with PTK2/FAK1
Subcellular location: Cytoplasm
Subcellular location: Isoform p46Shc: Mitochondrion matrix. Note=Localized to the mitochondria matrix. Targeting ofisoform p46Shc to mitochondria is mediated by its first 32 amino acids, which behave as a bona fide mitochondrialtargeting sequence. Isoform p52Shc and isoform p66Shc, that contain the same sequence but more internally located,display a different subcellular localization
Subcellular location: Isoform p66Shc: Mitochondrion (By similarity). Note=In case of oxidative conditions,phosphorylation at 'Ser-36' of isoform p66Shc, leads to mitochondrial accumulation (By similarity)
Sequence caution: Sequence=CAI13254.1; Type=Erroneous gene model prediction;
6/8 PDB 3D structures from  and Proteopedia  for SHC1 (see all 8):1MIL (3D)
1N3H (3D)
1OY2 (3D)
1QG1 (3D)
1SHC (3D)
1TCE (3D)
Secondary accessions: B5BU19 D3DV78 O15290 Q5T180 Q5T183 Q5T184 Q5T185 Q5T186 Q8N4K5 Q96CL1Alternative promoter usage, Alternative splicing: 6 isoforms: P29353-1 P29353-2 P29353-3 P29353-5 P29353-6 P29353-7 (Produced by alternative splicing)Explore the universe of human proteins at neXtProt for SHC1: NX_P29353
Post-translational modifications:
Phosphorylated by activated epidermal growth factor receptor. Phosphorylated in response to FLT4 and KIT signaling.Isoform p46Shc and isoform p52Shc are phosphorylated on tyrosine residues of the Pro-rich domain. Isoform p66Shc isphosphorylated on Ser-36 by PRKCB upon treatment with insulin, hydrogen peroxide or irradiation with ultraviolet light(By similarity). Tyrosine phosphorylated in response to FLT3 signaling (By similarity). Tyrosine phosphorylated byactivated PTK2B/PYK2 (By similarity). Tyrosine phosphorylated by ligand-activated ALK. Tyrosine phosphorylated byligand-activated PDGFRB. Tyrosine phosphorylated by TEK/TIE2. May be tyrosine phosphorylated by activated PTK2/FAK1;tyrosine phosphorylation was seen in an astrocytoma biopsy, where PTK2/FAK1 kinase activity is high, but not in normalbrain tissue1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P29353
SHC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001123512.1 NP_001123513.1 NP_001189788.1 NP_003020.2 NP_892113.4
ENSEMBL proteins: ENSP00000357430 ENSP00000401303 ENSP00000357434 ENSP00000357438 ENSP00000357435 ENSP00000396333 ENSP00000404908 ENSP00000398864 ENSP00000398441 ENSP00000396162 Reactome Protein details: P29353
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
SHC1 for ontologies About GeneDecksing
SHC1 Antibody Products:
Assay Products for SHC1: |
Protein
Domains /
Families
for SHC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SHC1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P29353ProtoNet protein and cluster: P29353 2 Blocks protein families: IPB006019 SHC phosphotyrosine interaction domain signature IPB006020 Phosphotyrosine interaction domain
UniProtKB/Swiss-Prot: SHC1_HUMAN, P29353Domain: In response to a variety of growth factors, isoform p46Shc and isoform p52Shc bind to phosphorylated Trkreceptors through their phosphotyrosine binding (PID) and/or SH2 domains. The PID and SH2 domains bind to specificphosphorylated tyrosine residues in the Asn-Pro-Xaa-Tyr(P) motif of the Trk receptors. Isoform p46Shc and isoformp52Shc are in turn phosphorylated on three tyrosine residues within the extended proline-rich domain. Thesephosphotyrosines act as docking site for GRB2 and thereby are involved in Ras activation (By similarity)Similarity: Contains 1 PID domainSimilarity: Contains 1 SH2 domain |
Function
for SHC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SHC1_HUMAN, P29353Function: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in asignaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated,couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated inthe cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators ofthe Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but isinvolved in signal transduction pathways that regulate the cellular response to oxidative stress and life span.Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability ofstress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expressionof isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of theangiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sproutingangiogenesis Genatlas biochemistry entry for SHC1:transduction adaptor protein SHC,tyrosine-phosphorylated during insulin and EGFR stimulation,interacting withGRB2,independently of IRS1,forming multimeric complexes with EGFR,SOS,GRB2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SHC1 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SHC1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector (see all 5): SHC1 (NM_001130040) | |  | Sino Biological Human cDNA Clone for SHC1 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SHC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHC1 |
Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13): About this table
SHC1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SHC1:
Animal Models:
Mouse knock-outs for SHC1: Shc1tm8Paw Shc1tm1Lex Shc1tm9.1Paw Shc1tm1Paw Shc1tm1Pgp
15/16 MGI mutant phenotypes (inferred from 13 alleles ) (MGI details for Shc1) (see all 16):
SHC1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SHC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/102 super-pathways (see all 102) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development_CNTF receptor signaling | | | 2 | IL-9 Signaling Pathways | | | 3 | Development HGF signaling pathway | | | 4 | Signaling by FGFR | | | 5 | Development Angiotensin activation of ERK | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/69 EMD Millipore Pathways for SHC1 (see all 69)
5/9  R&D Systems Pathways for SHC1 (see all 9)
1 
Cell Signaling Technology (CST) Pathway for SHC1
5/71  GeneGo (Thomson Reuters) Pathways for SHC1 (see all 71)
5/47  BioSystems Pathways for SHC1 (see all 47)
5/56 
Reactome Pathways for SHC1 (see all 56)
1  PharmGKB Pathway for SHC1
5/9 
Kegg Pathways (Kegg details for SHC1) (see all 9):
SHC1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SHC1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/847 Interacting proteins for SHC1 (P293531, 2, 3 ENSP000004013034) via UniProtKB, MINT, STRING, and/or I2D (see all 847)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| GRB2 | P629931, 2, 3, ENSP000003390074 | EBI-78835,EBI-401755 MINT-6169992 MINT-8032691 MINT-8032762 MINT-8028762 MINT-7135507 MINT-8032822 MINT-8032838 MINT-61537 MINT-8032721 MINT-60983 MINT-1782399 MINT-8401377 MINT-7135483 MINT-8032777 MINT-49658 MINT-60982 MINT-8401389 MINT-7135494 I2D:
score=15 STRING: ENSP00000339007 | | ERBB2 | P046262, 3, ENSP000002695714 | MINT-61504 MINT-61511 MINT-61510 MINT-74737 MINT-74736 MINT-74735 MINT-61506 MINT-74734 MINT-74733 MINT-61508 I2D:
score=8 STRING: ENSP00000269571 | | EGFR | P005331, 2, 3, ENSP000002754934 | EBI-78835,EBI-297353 MINT-74727 MINT-74729 MINT-8038549 MINT-74731 MINT-1782377 MINT-8038504 MINT-61491 MINT-1782352 MINT-74732 MINT-8401401 MINT-61499 MINT-8038534 MINT-61501 MINT-17353 MINT-74730 MINT-8401377 MINT-61495 MINT-61482 MINT-74728 MINT-61503 MINT-61489 MINT-8038489 MINT-8038564 I2D:
score=10 STRING: ENSP00000275493 | | APP | P050671, 2, 3, ENSP000002849814 | EBI-78835,EBI-77613 MINT-49660 I2D:
score=6 STRING: ENSP00000284981 | | ERBB3 | P218602, 3, ENSP000002671014 | MINT-74738 MINT-74725 MINT-61521 MINT-74726 I2D:
score=6 STRING: ENSP00000267101 |
About this table
Gene Ontology (GO): 5/35 biological process terms (GO ID links to tree view) (see all 35): About this table
SHC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SHC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SHC1 for compounds About GeneDecksing
 Browse Tocris compounds for SHC1
10/76 Novoseek chemical compound relationships for SHC1 gene (see all 76) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
90.3 |
983 |
10570274 (8), 8036006 (7), 7542991 (6), 9710204 (6) (see all 99) |
| phosphotyrosine |
86.8 |
137 |
7542744 (4), 8537373 (4), 7542991 (3), 9271429 (3) (see all 78) |
| phosphatidylinositol |
79.4 |
78 |
8022784 (2), 9761726 (2), 7692230 (2), 11278505 (2) (see all 65) |
| ag 1478 |
68.3 |
9 |
9722539 (1), 17956904 (1), 19804820 (1), 10702246 (1) (see all 7) |
| pd 98,059 |
62.3 |
2 |
11228049 (1), 19167776 (1) |
| inositol |
59.7 |
18 |
9973396 (2), 9099679 (1), 10570274 (1), 8805618 (1) (see all 15) |
| phosphatidylinositol-3,4,5-trisphosphate |
59.1 |
2 |
10194451 (1), 7650013 (1) |
| wortmannin |
55 |
9 |
11897789 (3), 8660383 (1), 10644984 (1), 18385518 (1) (see all 6) |
| phenylalanine |
54.7 |
20 |
7542991 (1), 8567619 (1), 9388490 (1), 10499514 (1) (see all 18) |
| ly294002 |
46.4 |
2 |
11897789 (1), 11228049 (1) |
Search CenterWatch for drugs/clinical trials and news about SHC1
|
Transcripts
for SHC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SHC1 gene (5 alternative transcripts): NM_001130040.1 NM_001130041.1 NM_001202859.1 NM_003029.4 NM_183001.4 Unigene Cluster for SHC1: SHC (Src homology 2 domain containing) transforming protein 1 Hs.433795 [show with all ESTs]Unigene Representative Sequence: BX64714911 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000368445 ENST00000448116(uc001ffw.3 uc001ffv.3) ENST00000368449
ENST00000368453(uc001ffx.3) ENST00000368450(uc001ffz.1 uc001ffy.3)
ENST00000490667 ENST00000444664 ENST00000414115 ENST00000444179 ENST00000412170
ENST00000366442
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SHC1 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SHC1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 5): SHC1 (NM_001130040) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SHC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHC1 |
Additional cDNA sequence: AB451255.1 AB451379.1 AK096169.1 AK130014.1 AK225332.1 AK292143.1 AK296786.1 AK315842.1 BC011813.1 BC014158.2 BC017283.1 BC033925.1 BX647136.1 BX647149.1 X68148.1 24/39 DOTS entries (see all 39): DT.40287869 DT.447555 DT.100846065 DT.121414070 DT.91794052 DT.121413736 DT.100846072 DT.121413914 DT.99970890 DT.102835757 DT.91850144 DT.97779549 DT.121413965 DT.121413815 DT.100761500 DT.95212663 DT.121413963 DT.100715607 DT.91775292 DT.100719206 DT.100846068 DT.102835755 DT.99952056 DT.100059561 24/662 AceView cDNA sequences (see all 662): BC017283 AK095425 BU541173 AI813965 BE466258 BQ953225 BQ651168 BQ962516 T50498 AW149090 BQ219824 AW168209 BC006132 AK092389 BQ962736 BQ939807 AV654127 BM005716 BF054991 BC013725 CB152347 BE887474 BQ218463 BQ673064
GeneLoc Exon Structure
5/16 Alternative Splicing Database (ASD) splice patterns (SP) for SHC1 (see all 16) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | |
| ExUns: | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · | 19b | · | 19c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for SHC1
|
Expression
for SHC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SHC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGGGGAAAC
About this image
See SHC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SHC1
SOURCE GeneReport for Unigene cluster: Hs.433795
UniProtKB/Swiss-Prot: SHC1_HUMAN, P29353Tissue specificity: Widely expressed. Expressed in neural stem cells but absent in mature neurons
SABiosciences Expression via Pathway-Focused PCR Arrays including SHC1 (see all 6):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SHC1
Browse OriGene validated miRNA SYBR primer pairs
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Orthologs
for SHC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SHC1 gene from 6/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SHC11 |
SHC (Src homology 2 domain containing) transforming more |
75.35(n)
81.87(a) |
|
395934 XM_424373.3 XP_424373.3 |
lizard
(Anolis carolinensis) |
Reptilia |
SHC16 |
-- |
73(a) |
1 ↔ 1 |
GL344009.1(24433-31870) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.32102 |
Xenopus laevis src homology collagen mRNA, complete more |
77.69(n) |
|
AY027793.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufc10h032 |
Transcribed sequence with weak similarity to protein more |
80.57(n) |
|
BM157048.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Shc3 |
EGF receptor signaling pathway |
39(a) |
|
3 67B4 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
shc-16 |
SHC (Src Homology domain C-terminal) adaptor homol... |
29(a) |
1 → many |
I(969683-973140) |
ENSEMBL Gene Tree for SHC1 (if available)
TreeFam Gene Tree for SHC1 (if available) |
Paralogs
for SHC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SHC1 gene
- SHC42 SHC22 SHC32
5 SIMAP similar genes for SHC1 using alignment to 6 protein entries: SHC1_HUMAN (see all proteins):L3MBTL2 SHC4 ETFA SHC3 SHC2
SHC1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for SHC1
PGOHUM00000237082 PGOHUM00000241811
|
Genomic Variants
for SHC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SHC1 (154934774 - 154946959 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SHC1: -- | SABiosciences Cancer Mutation PCR Assays |
| 1 SABiosciences qBiomarker Copy Number PCR Array containing SHC1: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SHC1 |
|
Disorders
/ Diseases
for SHC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SHC1 for disorders About GeneDecksing
OMIM gene information: 600560
OMIM disorders: --
20/56  diseases for SHC1 (see all 56): About MalaCardsmultiple endocrine neoplasia type 2a suppurative lymphadenitis multiple endocrine neoplasia wiskott-aldrich syndrome
non-hodgkin lymphoma type 2 diabetes mellitus cancer progression/metastasis venous malformations
myeloid leukemia insulin resistance hodgkin's lymphoma diabetes mellitus
lymphadenitis anaplastic astrocytoma chronic lymphocytic leukemia chronic myeloid leukemia
acute myeloid leukemia lymphocytic leukemia leukemia pheochromocytoma
10/37 Novoseek disease relationships for SHC1 gene (see all 37) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| men 2a |
43.7 |
6 |
10465268 (2), 9047384 (1) |
| breast cancer |
39.5 |
42 |
8660324 (4), 10741744 (2), 17196107 (2), 14669164 (2) (see all 21) |
| neoplastic transformation |
20.7 |
1 |
8084588 (1) |
| men 3 |
16.1 |
1 |
9047384 (1) |
| prostate carcinoma |
11.8 |
2 |
14696093 (1), 11007941 (1) |
| pheochromocytoma |
9.15 |
2 |
8288573 (1), 8156997 (1) |
| tumors |
8.99 |
31 |
9714065 (5), 7675449 (4), 14669164 (2), 14583473 (2) (see all 17) |
| metastasis |
5.43 |
10 |
11896612 (2), 10741744 (1), 17699761 (1), 10527634 (1) (see all 6) |
| leukemia |
5.34 |
3 |
7537361 (1), 9096689 (1), 11016927 (1) |
| insulin resistance |
4.04 |
4 |
10372739 (2), 9267983 (1), 11788655 (1) |
Genetic Association Database (GAD): SHC1
Human Genome Epidemiology (HuGE) Navigator: SHC1 (6 documents)
Export disorders for SHC1 gene to outside databases
|
Publications
for SHC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SHC1 gene, integrated from 9 sources (see all 1053):
(articles sorted by number of sources associating them with SHC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. (PubMed id 1623525)1, 2, 3 Pelicci G.... Pelicci P.G. (1992)
- Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains. (PubMed id 7559478)1, 2, 9 He W.... Gustafson T.A. (1995)
- The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions. (PubMed id 8939605)1, 2, 9 van der Geer P.... Pawson T. (1996)
- Direct interaction between Shc and the platelet-derived growth factor beta-receptor. (PubMed id 8195171)1, 2, 9 Yokote K....Claesson-Welsh L. (1994)
- Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation. (PubMed id 9121430)1, 2, 9 Gotoh N....Shibuya M. (1997)
- Structure and ligand recognition of the phosphotyrosine binding domain of Shc. (PubMed id 8524391)1, 2, 9 Zhou M.M....Fesik S.W. (1995)
- Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells. (PubMed id 14665640)1, 2, 9 Audero E....Bussolino F. (2004)
- A cryptic targeting signal induces isoform-specific localization of p46Shc to mitochondria. (PubMed id 14573619)1, 2, 9 Ventura A.... Pelicci P.-G. (2004)
- EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. (PubMed id 12925710)1, 2, 9 Vindis C....Huynh-Do U. (2003)
- The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF- stimulated COS-7 cells. (PubMed id 11349134)1, 2, 9 Pesesse X.... Erneux C. (2001)
|
External Searches for SHC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SHC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SHC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SHC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SHC1 gene:
Search GeneIP for patents involving SHC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SHC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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