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Aliases for SHC1 Gene

Aliases for SHC1 Gene

  • SHC Adaptor Protein 1 2 3 5
  • SHC-Transforming Protein 3 3 4
  • SHC-Transforming Protein A 3 4
  • SH2 Domain Protein C1 3 4
  • SHCA 3 4
  • SHC 3 4
  • SHC (Src Homology 2 Domain-Containing) Transforming Protein 1 2
  • SHC (Src Homology 2 Domain Containing) Transforming Protein 1 3
  • Src Homology 2 Domain-Containing-Transforming Protein C1 4
  • SHC-Transforming Protein 1 3

External Ids for SHC1 Gene

Previous HGNC Symbols for SHC1 Gene

  • SHC

Previous GeneCards Identifiers for SHC1 Gene

  • GC01M152750
  • GC01M150665
  • GC01M151710
  • GC01M152151
  • GC01M151747
  • GC01M153201
  • GC01M154934
  • GC01M126296

Summaries for SHC1 Gene

Entrez Gene Summary for SHC1 Gene

  • This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for SHC1 Gene

SHC1 (SHC Adaptor Protein 1) is a Protein Coding gene. Diseases associated with SHC1 include Astrocytoma and Insulin-Like Growth Factor I. Among its related pathways are Transcription Androgen Receptor nuclear signaling and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. GO annotations related to this gene include protein tyrosine kinase activity and phospholipid binding. An important paralog of this gene is SHC4.

UniProtKB/Swiss-Prot for SHC1 Gene

  • Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.

Gene Wiki entry for SHC1 Gene

Additional gene information for SHC1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHC1 Gene

Genomics for SHC1 Gene

Regulatory Elements for SHC1 Gene

Enhancers for SHC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H155242 1.5 ENCODE dbSUPER 69.2 -269.8 -269751 2 FEZF1 YBX1 YY1 ZNF416 ZNF143 ZNF548 SP3 ZFP41 MEF2D ZNF610 KIAA0907 GON4L ENSG00000271267 CLK2 MSTO1 MSTO2P THBS3 RUSC1-AS1 LOC101928120 SHC1
GH01H154998 1.9 FANTOM5 ENCODE dbSUPER 29.1 -30.0 -29960 11 MLX YBX1 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC ZC3H11A PPARGC1A GON4L CLK2 UBAP2L KIAA0907 ENSG00000271267 MSTO1 RUSC1-AS1 THBS3 YY1AP1 FLAD1
GH01H155123 1.7 FANTOM5 ENCODE dbSUPER 23.6 -153.5 -153531 8 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 KIAA0907 GON4L CLK2 UBAP2L MSTO1 ENSG00000271267 MSTO2P LOC101928120 RUSC1-AS1 SHC1
GH01H155049 1.4 ENCODE dbSUPER 23.2 -77.2 -77193 4 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF766 ZNF207 CLK2 GON4L KIAA0907 ENSG00000271267 UBAP2L THBS3 SHC1 SSR2 RUSC1-AS1 KRTCAP2
GH01H154960 1.4 ENCODE dbSUPER 23.1 +11.9 11853 4 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 PAF1 KIAA0907 GON4L UBAP2L SHC1 ENSG00000271267 CLK2 MSTO2P ASH1L-AS1 RUSC1-AS1 LOC101928120
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SHC1 on UCSC Golden Path with GeneCards custom track

Promoters for SHC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014006 -308 2801 HDGF FOXA2 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1
ENSR00000254600 1592 201 HDGF FOXA2 MLX ARID4B FEZF1 DMAP1 YY1 ETS1 GLIS2 DEK

Genomic Location for SHC1 Gene

Chromosome:
1
Start:
154,962,298 bp from pter
End:
154,974,492 bp from pter
Size:
12,195 bases
Orientation:
Minus strand

Genomic View for SHC1 Gene

Genes around SHC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHC1 Gene

Proteins for SHC1 Gene

  • Protein details for SHC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29353-SHC1_HUMAN
    Recommended name:
    SHC-transforming protein 1
    Protein Accession:
    P29353
    Secondary Accessions:
    • B5BU19
    • D3DV78
    • O15290
    • Q5T180
    • Q5T183
    • Q5T184
    • Q5T185
    • Q5T186
    • Q8N4K5
    • Q96CL1

    Protein attributes for SHC1 Gene

    Size:
    583 amino acids
    Molecular mass:
    62822 Da
    Quaternary structure:
    • Interacts with CPNE3; this interaction may mediate the binding of CPNE3 with ERBB2 (PubMed:20010870). Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR in vitro via the PID domain. Once activated, binds to GRB2. Interacts with tyrosine-phosphorylated CD3T and DDR2. Interacts with the N-terminal region of APS. Interacts with phosphorylated LRP1 and IRS4. Interacts with INPP5D/SHIP1 and INPPL1/SHIP2. Interacts with TRIM31. Interacts with PTPN6/SHP (tyrosine phosphorylated). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTT (By similarity). Interacts with ALK, GAB2, GRB7 and KIT. Interacts with FLT4 (tyrosine-phosphorylated). Interacts with EPHB1 and GRB2; activates the MAPK/ERK cascade to regulate cell migration. Interacts with PDGFRB (tyrosine-phosphorylated). Interacts with ERBB4. Interacts with TEK/TIE2 (tyrosine-phosphorylated). Interacts with the Trk receptors NTRK1, NTRK2 and NTRK3; in a phosphotyrosine-dependent manner. Interacts with PTK2/FAK1. Interacts with herpes simplex virus 1 UL46. Interacts with CEACAM1; this interaction is CEACAM1-phosphorylation-dependent and mediates interaction with EGFR or INSR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity).
    SequenceCaution:
    • Sequence=CAI13254.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SHC1 Gene

    Alternative splice isoforms for SHC1 Gene

neXtProt entry for SHC1 Gene

Post-translational modifications for SHC1 Gene

  • Phosphorylated by activated epidermal growth factor receptor. Phosphorylated in response to FLT4 and KIT signaling. Isoform p46Shc and isoform p52Shc are phosphorylated on tyrosine residues of the Pro-rich domain. Isoform p66Shc is phosphorylated on Ser-36 by PRKCB upon treatment with insulin, hydrogen peroxide or irradiation with ultraviolet light (By similarity). Tyrosine phosphorylated in response to FLT3 signaling (By similarity). Tyrosine phosphorylated by activated PTK2B/PYK2 (By similarity). Tyrosine phosphorylated by ligand-activated ALK. Tyrosine phosphorylated by ligand-activated PDGFRB. Tyrosine phosphorylated by TEK/TIE2. May be tyrosine phosphorylated by activated PTK2/FAK1; tyrosine phosphorylation was seen in an astrocytoma biopsy, where PTK2/FAK1 kinase activity is high, but not in normal brain tissue. Isoform p52Shc dephosphorylation by PTPN2 may regulate interaction with GRB2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SHC1 Gene

Domains & Families for SHC1 Gene

Gene Families for SHC1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

P29353

UniProtKB/Swiss-Prot:

SHC1_HUMAN :
  • In response to a variety of growth factors, isoform p46Shc and isoform p52Shc bind to phosphorylated Trk receptors through their phosphotyrosine binding (PID) and/or SH2 domains. The PID and SH2 domains bind to specific phosphorylated tyrosine residues in the Asn-Pro-Xaa-Tyr(P) motif of the Trk receptors. Isoform p46Shc and isoform p52Shc are in turn phosphorylated on three tyrosine residues within the extended proline-rich domain. These phosphotyrosines act as docking site for GRB2 and thereby are involved in Ras activation (By similarity).
Domain:
  • In response to a variety of growth factors, isoform p46Shc and isoform p52Shc bind to phosphorylated Trk receptors through their phosphotyrosine binding (PID) and/or SH2 domains. The PID and SH2 domains bind to specific phosphorylated tyrosine residues in the Asn-Pro-Xaa-Tyr(P) motif of the Trk receptors. Isoform p46Shc and isoform p52Shc are in turn phosphorylated on three tyrosine residues within the extended proline-rich domain. These phosphotyrosines act as docking site for GRB2 and thereby are involved in Ras activation (By similarity).
genes like me logo Genes that share domains with SHC1: view

Function for SHC1 Gene

Molecular function for SHC1 Gene

GENATLAS Biochemistry:
transduction adaptor protein SHC,tyrosine-phosphorylated during insulin and EGFR stimulation,interacting with GRB2,independently of IRS1,forming multimeric complexes with EGFR,SOS,GRB2
UniProtKB/Swiss-Prot Function:
Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.

Phenotypes From GWAS Catalog for SHC1 Gene

Gene Ontology (GO) - Molecular Function for SHC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001784 phosphotyrosine binding IPI 20624904
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity TAS 14676841
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005154 epidermal growth factor receptor binding ISS --
GO:0005158 insulin receptor binding IPI 7537849
genes like me logo Genes that share ontologies with SHC1: view
genes like me logo Genes that share phenotypes with SHC1: view

Animal Models for SHC1 Gene

MGI Knock Outs for SHC1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SHC1

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SHC1 Gene

Localization for SHC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHC1 Gene

Cytoplasm.
Isoform p46Shc: Mitochondrion matrix. Note=Localized to the mitochondria matrix. Targeting of isoform p46Shc to mitochondria is mediated by its first 32 amino acids, which behave as a bona fide mitochondrial targeting sequence. Isoform p52Shc and isoform p66Shc, that contain the same sequence but more internally located, display a different subcellular localization.
Isoform p66Shc: Mitochondrion. Note=In case of oxidative conditions, phosphorylation at Ser-36 of isoform p66Shc, leads to mitochondrial accumulation. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SHC1 gene
Compartment Confidence
plasma membrane 5
cytosol 5
mitochondrion 4
nucleus 4
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
endosome 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SHC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005759 mitochondrial matrix IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SHC1: view

Pathways & Interactions for SHC1 Gene

SuperPathway Contained pathways
1 RET signaling
2 Regulation of lipid metabolism Insulin signaling-generic cascades
3 Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
4 Downstream signaling of activated FGFR2
5 Development Angiotensin activation of ERK
genes like me logo Genes that share pathways with SHC1: view

SIGNOR curated interactions for SHC1 Gene

Activates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for SHC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity IMP 20624904
GO:0001525 angiogenesis IEA --
GO:0007165 signal transduction IEA --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with SHC1: view

Drugs & Compounds for SHC1 Gene

(41) Drugs for SHC1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(35) Additional Compounds for SHC1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SHC1: view

Transcripts for SHC1 Gene

Unigene Clusters for SHC1 Gene

SHC (Src homology 2 domain containing) transforming protein 1:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHC1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3:
SP4:
SP5: - - - - - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - -
SP8:
SP9:
SP10: - - - - - - - - - - - -
SP11: - - - - - - -
SP12: - - - - - -
SP13: - - - -
SP14: - -
SP15: - - - - - - - - - - -
SP16:

ExUns: 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9: - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for SHC1 Gene

GeneLoc Exon Structure for
SHC1
ECgene alternative splicing isoforms for
SHC1

Expression for SHC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SHC1 Gene

Protein differential expression in normal tissues from HIPED for SHC1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.9) and Heart (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SHC1 Gene



Protein tissue co-expression partners for SHC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SHC1 Gene:

SHC1

SOURCE GeneReport for Unigene cluster for SHC1 Gene:

Hs.433795

mRNA Expression by UniProt/SwissProt for SHC1 Gene:

P29353-SHC1_HUMAN
Tissue specificity: Widely expressed. Expressed in neural stem cells but absent in mature neurons.

Evidence on tissue expression from TISSUES for SHC1 Gene

  • Nervous system(4.8)
  • Liver(4.6)
  • Skin(4.3)
  • Kidney(3.9)
  • Lung(3.5)
  • Pancreas(3.3)
  • Muscle(2.9)
  • Adrenal gland(2.8)
  • Heart(2.6)
  • Blood(2.4)
  • Thyroid gland(2.4)
  • Intestine(2.3)
  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with SHC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SHC1 Gene

Orthologs for SHC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SHC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SHC1 33 34
  • 98.97 (n)
cow
(Bos Taurus)
Mammalia SHC1 33 34
  • 91.94 (n)
dog
(Canis familiaris)
Mammalia SHC1 33 34
  • 91.15 (n)
mouse
(Mus musculus)
Mammalia Shc1 33 16 34
  • 89.87 (n)
oppossum
(Monodelphis domestica)
Mammalia SHC1 34
  • 89 (a)
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