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Aliases for SHC1 Gene

Aliases for SHC1 Gene

  • SHC Adaptor Protein 1 2 3 5
  • SHC-Transforming Protein 3 3 4
  • SHC-Transforming Protein A 3 4
  • SH2 Domain Protein C1 3 4
  • SHCA 3 4
  • SHC 3 4
  • SHC (Src Homology 2 Domain-Containing) Transforming Protein 1 2
  • SHC (Src Homology 2 Domain Containing) Transforming Protein 1 3
  • Src Homology 2 Domain-Containing-Transforming Protein C1 4
  • SHC-Transforming Protein 1 3

External Ids for SHC1 Gene

Previous HGNC Symbols for SHC1 Gene

  • SHC

Previous GeneCards Identifiers for SHC1 Gene

  • GC01M152750
  • GC01M150665
  • GC01M151710
  • GC01M152151
  • GC01M151747
  • GC01M153201
  • GC01M154934
  • GC01M126296

Summaries for SHC1 Gene

Entrez Gene Summary for SHC1 Gene

  • This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for SHC1 Gene

SHC1 (SHC Adaptor Protein 1) is a Protein Coding gene. Diseases associated with SHC1 include Astrocytoma and Insulin-Like Growth Factor I. Among its related pathways are RET signaling and Signaling by GPCR. GO annotations related to this gene include protein tyrosine kinase activity and phospholipid binding. An important paralog of this gene is SHC4.

UniProtKB/Swiss-Prot for SHC1 Gene

  • Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.

Gene Wiki entry for SHC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHC1 Gene

Genomics for SHC1 Gene

Regulatory Elements for SHC1 Gene

Enhancers for SHC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F154965 0.4 ENCODE 13 +2.4 2439 12.2 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF416 ZNF143 KRTCAP2 KIAA0907 THBS3 RPS27 ENSG00000271267 SHC1 ASH1L ADAM15 DCST1-AS1 RUSC1-AS1
GH01F154982 0.2 ENCODE 12.1 -9.2 -9160 2.8 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 KIAA0907 LOC101928120 SHC1 MIR92B ASH1L-AS1 FLAD1 LENEP
GH01F154994 0.9 Ensembl ENCODE 11.7 -20.9 -20909 1.6 BCOR CTCF ZNF384 BMI1 ZIC2 RAD21 TEAD3 ZNF316 POLR2A HSF1 PYGO2 SHC1 ADAM15 DCST1-AS1 EFNA4 ENSG00000251246 EFNA3 CHRNB2 UBE2Q1 KRTCAP2
GH01F154960 0.7 ENCODE 11.4 +11.9 11853 4.5 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 LOC101928120 KRTCAP2 KIAA0907 RAB13 SHC1 TDRD10 ENSG00000272654 RPS27 ASH1L-AS1 THBS3
GH01F154998 1.1 FANTOM5 ENCODE 11.3 -30.0 -29960 11.3 MLX CREB3L1 ZFP64 FEZF1 YBX1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 KIAA0907 THBS3 ENSG00000271267 RUSC1-AS1 ASH1L-AS1 MSTO2P KRTCAP2 ZBTB7B LOC101928120 EFNA4
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SHC1 on UCSC Golden Path with GeneCards custom track

Promoters for SHC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000545467 -308 3201 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1
ENSR00001750378 1692 401 HDGF MLX SIN3A ARID4B FEZF1 DMAP1 ZNF48 ETS1 YY1 GLIS2

Genomic Location for SHC1 Gene

Chromosome:
1
Start:
154,962,298 bp from pter
End:
154,974,492 bp from pter
Size:
12,195 bases
Orientation:
Minus strand

Genomic View for SHC1 Gene

Genes around SHC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHC1 Gene

Proteins for SHC1 Gene

  • Protein details for SHC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29353-SHC1_HUMAN
    Recommended name:
    SHC-transforming protein 1
    Protein Accession:
    P29353
    Secondary Accessions:
    • B5BU19
    • D3DV78
    • O15290
    • Q5T180
    • Q5T183
    • Q5T184
    • Q5T185
    • Q5T186
    • Q8N4K5
    • Q96CL1

    Protein attributes for SHC1 Gene

    Size:
    583 amino acids
    Molecular mass:
    62822 Da
    Quaternary structure:
    • Interacts with CPNE3; this interaction may mediate the binding of CPNE3 with ERBB2 (PubMed:20010870). Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR in vitro via the PID domain. Once activated, binds to GRB2. Interacts with tyrosine-phosphorylated CD3T and DDR2. Interacts with the N-terminal region of APS. Interacts with phosphorylated LRP1 and IRS4. Interacts with INPP5D/SHIP1 and INPPL1/SHIP2. Interacts with TRIM31. Interacts with PTPN6/SHP (tyrosine phosphorylated). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTT (By similarity). Interacts with ALK, GAB2, GRB7 and KIT. Interacts with FLT4 (tyrosine-phosphorylated). Interacts with EPHB1 and GRB2; activates the MAPK/ERK cascade to regulate cell migration. Interacts with PDGFRB (tyrosine-phosphorylated). Interacts with ERBB4. Interacts with TEK/TIE2 (tyrosine-phosphorylated). Interacts with the Trk receptors NTRK1, NTRK2 and NTRK3; in a phosphotyrosine-dependent manner. Interacts with PTK2/FAK1. Interacts with herpes simplex virus 1 UL46. Interacts with CEACAM1; this interaction is CEACAM1-phosphorylation-dependent and mediates interaction with EGFR or INSR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity).
    SequenceCaution:
    • Sequence=CAI13254.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SHC1 Gene

    Alternative splice isoforms for SHC1 Gene

neXtProt entry for SHC1 Gene

Post-translational modifications for SHC1 Gene

  • Phosphorylated by activated epidermal growth factor receptor. Phosphorylated in response to FLT4 and KIT signaling. Isoform p46Shc and isoform p52Shc are phosphorylated on tyrosine residues of the Pro-rich domain. Isoform p66Shc is phosphorylated on Ser-36 by PRKCB upon treatment with insulin, hydrogen peroxide or irradiation with ultraviolet light (By similarity). Tyrosine phosphorylated in response to FLT3 signaling (By similarity). Tyrosine phosphorylated by activated PTK2B/PYK2 (By similarity). Tyrosine phosphorylated by ligand-activated ALK. Tyrosine phosphorylated by ligand-activated PDGFRB. Tyrosine phosphorylated by TEK/TIE2. May be tyrosine phosphorylated by activated PTK2/FAK1; tyrosine phosphorylation was seen in an astrocytoma biopsy, where PTK2/FAK1 kinase activity is high, but not in normal brain tissue. Isoform p52Shc dephosphorylation by PTPN2 may regulate interaction with GRB2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SHC1 Gene

Domains & Families for SHC1 Gene

Gene Families for SHC1 Gene

Graphical View of Domain Structure for InterPro Entry

P29353

UniProtKB/Swiss-Prot:

SHC1_HUMAN :
  • In response to a variety of growth factors, isoform p46Shc and isoform p52Shc bind to phosphorylated Trk receptors through their phosphotyrosine binding (PID) and/or SH2 domains. The PID and SH2 domains bind to specific phosphorylated tyrosine residues in the Asn-Pro-Xaa-Tyr(P) motif of the Trk receptors. Isoform p46Shc and isoform p52Shc are in turn phosphorylated on three tyrosine residues within the extended proline-rich domain. These phosphotyrosines act as docking site for GRB2 and thereby are involved in Ras activation (By similarity).
Domain:
  • In response to a variety of growth factors, isoform p46Shc and isoform p52Shc bind to phosphorylated Trk receptors through their phosphotyrosine binding (PID) and/or SH2 domains. The PID and SH2 domains bind to specific phosphorylated tyrosine residues in the Asn-Pro-Xaa-Tyr(P) motif of the Trk receptors. Isoform p46Shc and isoform p52Shc are in turn phosphorylated on three tyrosine residues within the extended proline-rich domain. These phosphotyrosines act as docking site for GRB2 and thereby are involved in Ras activation (By similarity).
  • Contains 1 PID domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SHC1: view

Function for SHC1 Gene

Molecular function for SHC1 Gene

GENATLAS Biochemistry:
transduction adaptor protein SHC,tyrosine-phosphorylated during insulin and EGFR stimulation,interacting with GRB2,independently of IRS1,forming multimeric complexes with EGFR,SOS,GRB2
UniProtKB/Swiss-Prot Function:
Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.

Gene Ontology (GO) - Molecular Function for SHC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity TAS 14676841
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005154 epidermal growth factor receptor binding ISS --
GO:0005158 insulin receptor binding IPI 7537849
GO:0005159 insulin-like growth factor receptor binding IPI 7541045
genes like me logo Genes that share ontologies with SHC1: view
genes like me logo Genes that share phenotypes with SHC1: view

Animal Models for SHC1 Gene

MGI Knock Outs for SHC1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SHC1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SHC1 Gene

Localization for SHC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHC1 Gene

Cytoplasm.
Isoform p46Shc: Mitochondrion matrix. Note=Localized to the mitochondria matrix. Targeting of isoform p46Shc to mitochondria is mediated by its first 32 amino acids, which behave as a bona fide mitochondrial targeting sequence. Isoform p52Shc and isoform p66Shc, that contain the same sequence but more internally located, display a different subcellular localization.
Isoform p66Shc: Mitochondrion. Note=In case of oxidative conditions, phosphorylation at Ser-36 of isoform p66Shc, leads to mitochondrial accumulation. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SHC1 Gene COMPARTMENTS Subcellular localization image for SHC1 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5
mitochondrion 4
endosome 3
cytoskeleton 2
endoplasmic reticulum 2
extracellular 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SHC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005759 mitochondrial matrix IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SHC1: view

Pathways & Interactions for SHC1 Gene

SuperPathways for SHC1 Gene

SuperPathway Contained pathways
1 RET signaling
2 Translation Insulin regulation of translation
3 Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
4 Downstream signaling of activated FGFR2
5 Development Angiotensin activation of ERK
genes like me logo Genes that share pathways with SHC1: view

SIGNOR curated interactions for SHC1 Gene

Activates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for SHC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity IDA 14676841
GO:0001525 angiogenesis IEA --
GO:0007165 signal transduction IEA --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with SHC1: view

Drugs & Compounds for SHC1 Gene

(41) Drugs for SHC1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(35) Additional Compounds for SHC1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SHC1: view

Transcripts for SHC1 Gene

Unigene Clusters for SHC1 Gene

SHC (Src homology 2 domain containing) transforming protein 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHC1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3:
SP4:
SP5: - - - - - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - -
SP8:
SP9:
SP10: - - - - - - - - - - - -
SP11: - - - - - - -
SP12: - - - - - -
SP13: - - - -
SP14: - -
SP15: - - - - - - - - - - -
SP16:

ExUns: 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9: - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for SHC1 Gene

GeneLoc Exon Structure for
SHC1
ECgene alternative splicing isoforms for
SHC1

Expression for SHC1 Gene

mRNA expression in normal human tissues for SHC1 Gene

Protein differential expression in normal tissues from HIPED for SHC1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.9) and Heart (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SHC1 Gene



Protein tissue co-expression partners for SHC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SHC1 Gene:

SHC1

SOURCE GeneReport for Unigene cluster for SHC1 Gene:

Hs.433795

mRNA Expression by UniProt/SwissProt for SHC1 Gene:

P29353-SHC1_HUMAN
Tissue specificity: Widely expressed. Expressed in neural stem cells but absent in mature neurons.
genes like me logo Genes that share expression patterns with SHC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SHC1 Gene

Orthologs for SHC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SHC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SHC1 34 35
  • 98.97 (n)
cow
(Bos Taurus)
Mammalia SHC1 34 35
  • 91.94 (n)
dog
(Canis familiaris)
Mammalia SHC1 34 35
  • 91.15 (n)
mouse
(Mus musculus)
Mammalia Shc1 34 16 35
  • 89.87 (n)
oppossum
(Monodelphis domestica)
Mammalia SHC1 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Shc1 34
  • 88.89 (n)
chicken
(Gallus gallus)
Aves SHC1 34 35
  • 75.23 (n)
lizard
(Anolis carolinensis)
Reptilia SHC1 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492349 34
  • 74.49 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3210 34
zebrafish
(Danio rerio)
Actinopterygii shc1 34 35
  • 71.17 (n)
wufc10h03 34
fruit fly
(Drosophila melanogaster)
Insecta Shc 36 35
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea shc-1 35
  • 33 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9150 34
Species where no ortholog for SHC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SHC1 Gene

ENSEMBL:
Gene Tree for SHC1 (if available)
TreeFam:
Gene Tree for SHC1 (if available)

Paralogs for SHC1 Gene

Paralogs for SHC1 Gene

(5) SIMAP similar genes for SHC1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for SHC1 Gene

genes like me logo Genes that share paralogs with SHC1: view

Variants for SHC1 Gene

Sequence variations from dbSNP and Humsavar for SHC1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1050944 -- 154,965,641(-) ACTTC(C/T)TGGTA reference, synonymous-codon
rs1050947 -- 154,963,029(-) ACTCT(A/G)CGCCA downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs111229527 -- 154,968,516(+) GCCAT(A/C/G)AGGTT reference, synonymous-codon
rs111309814 -- 154,970,861(+) GGGCT(A/G)AGCCC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs111418361 -- 154,966,317(+) AACTT(A/G)CCAAT splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for SHC1 Gene

Variant ID Type Subtype PubMed ID
nsv509502 CNV insertion 20534489
nsv946408 CNV duplication 23825009

Variation tolerance for SHC1 Gene

Residual Variation Intolerance Score: 21.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.95; 74.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SHC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SHC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHC1 Gene

Disorders for SHC1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SHC1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
astrocytoma
  • astrocytic tumor
insulin-like growth factor i
  • insulin-like growth factor i deficiency
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search SHC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SHC1

Genetic Association Database (GAD)
SHC1
Human Genome Epidemiology (HuGE) Navigator
SHC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SHC1
genes like me logo Genes that share disorders with SHC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SHC1 Gene

Publications for SHC1 Gene

  1. EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. (PMID: 12925710) Vindis C. … Huynh-Do U. (J. Cell Biol. 2003) 3 4 22 64
  2. A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5- phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells. (PMID: 10194451) Wisniewski D. … Clarkson B. (Blood 1999) 3 4 22 64
  3. Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation. (PMID: 9121430) Gotoh N. … Shibuya M. (Mol. Cell. Biol. 1997) 3 4 22 64
  4. The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions. (PMID: 8939605) van der Geer P. … Pawson T. (Curr. Biol. 1996) 3 4 22 64
  5. Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains. (PMID: 7559478) He W. … Gustafson T.A. (J. Biol. Chem. 1995) 3 4 22 64

Products for SHC1 Gene