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Aliases for SHBG Gene

Aliases for SHBG Gene

  • Sex Hormone Binding Globulin 2 3 5
  • Testis-Specific Androgen-Binding Protein 3 4
  • Testosterone-Estradiol-Binding Globulin 3 4
  • Testosterone-Estrogen-Binding Globulin 3 4
  • Sex Hormone-Binding Globulin 2 3
  • Sex Steroid-Binding Protein 3 4
  • TEBG 3 4
  • ABP 3 4
  • SBP 3 4
  • Testosterone-Binding Beta-Globulin 3
  • Androgen Binding Protein 2

External Ids for SHBG Gene

Previous GeneCards Identifiers for SHBG Gene

  • GC17P007947
  • GC17P008273
  • GC17P007474
  • GC17P007734
  • GC17P007731
  • GC17P007472
  • GC17P007535
  • GC17P007413
  • GC17P007519
  • GC17P007523

Summaries for SHBG Gene

Entrez Gene Summary for SHBG Gene

  • This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for SHBG Gene

SHBG (Sex Hormone Binding Globulin) is a Protein Coding gene. Diseases associated with SHBG include Polycystic Ovary Syndrome and Anovulation. Among its related pathways are Nongenotropic Androgen signaling and Androgen Signaling. GO annotations related to this gene include androgen binding. An important paralog of this gene is PROS1.

UniProtKB/Swiss-Prot for SHBG Gene

  • Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.

Gene Wiki entry for SHBG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHBG Gene

Genomics for SHBG Gene

Regulatory Elements for SHBG Gene

Enhancers for SHBG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SHBG on UCSC Golden Path with GeneCards custom track

Promoters for SHBG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SHBG on UCSC Golden Path with GeneCards custom track

Genomic Location for SHBG Gene

Chromosome:
17
Start:
7,613,946 bp from pter
End:
7,633,383 bp from pter
Size:
19,438 bases
Orientation:
Plus strand

Genomic View for SHBG Gene

Genes around SHBG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHBG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHBG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHBG Gene

Proteins for SHBG Gene

  • Protein details for SHBG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04278-SHBG_HUMAN
    Recommended name:
    Sex hormone-binding globulin
    Protein Accession:
    P04278
    Secondary Accessions:
    • B0FWH4
    • E9PGW1
    • F5H5Z8
    • I3L1N7
    • P14689
    • Q16616
    • Q3MIL0
    • Q6ISD2

    Protein attributes for SHBG Gene

    Size:
    402 amino acids
    Molecular mass:
    43779 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=CAA29309.1; Type=Frameshift; Positions=47, 52, 54; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SHBG Gene

    Alternative splice isoforms for SHBG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SHBG Gene

Post-translational modifications for SHBG Gene

  • Variant Asn-356 contains one N-linked (GlcNAc...) at position 356.
  • Glycosylation at Thr 36, Asn 380, and Asn 396
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SHBG Gene

Domains & Families for SHBG Gene

Protein Domains for SHBG Gene

Graphical View of Domain Structure for InterPro Entry

P04278

UniProtKB/Swiss-Prot:

SHBG_HUMAN :
  • Contains 2 laminin G-like domains.
Domain:
  • Contains 2 laminin G-like domains.
genes like me logo Genes that share domains with SHBG: view

No data available for Gene Families for SHBG Gene

Function for SHBG Gene

Molecular function for SHBG Gene

GENATLAS Biochemistry:
sex hormone-binding globulin gene
UniProtKB/Swiss-Prot Function:
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.

Gene Ontology (GO) - Molecular Function for SHBG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005496 steroid binding IEA --
GO:0005497 androgen binding TAS 2587256
genes like me logo Genes that share ontologies with SHBG: view
genes like me logo Genes that share phenotypes with SHBG: view

Animal Model Products

CRISPR Products

miRNA for SHBG Gene

miRTarBase miRNAs that target SHBG

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SHBG Gene

Localization for SHBG Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHBG Gene

Secreted. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SHBG Gene COMPARTMENTS Subcellular localization image for SHBG gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
plasma membrane 2
golgi apparatus 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SHBG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SHBG: view

Pathways & Interactions for SHBG Gene

genes like me logo Genes that share pathways with SHBG: view

Pathways by source for SHBG Gene

1 BioSystems pathway for SHBG Gene
1 Qiagen pathway for SHBG Gene

Gene Ontology (GO) - Biological Process for SHBG Gene

None

No data available for SIGNOR curated interactions for SHBG Gene

Drugs & Compounds for SHBG Gene

(96) Drugs for SHBG Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Danazol Approved Pharma Carrier 15
Estradiol Approved, Investigational, Vet_approved Pharma Carrier Sex hormone 1250
Testosterone Approved, Investigational Pharma Carrier, other/unknown Endogenous androgen receptor agonist 524
Estrone sulfate Approved Pharma Carrier 0
Hydrocortisone Approved, Vet_approved Pharma Agonist, Carrier Adrenal glucocorticoid; immunosuppressant 602

(38) Additional Compounds for SHBG Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Methoxyestrone
  • 2-(8S,9S,13S,14S)-3-Hydroxy-2-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
  • 2-Hydroxyestrone 2-methyl ether
  • 2-Methoxy-17-oxoestra-1,3,5(10)-trien-3-ol
  • 2-Methoxy-3-hydroxyestra-1,3,5(10)-trien-17-one
  • 3-Hydroxy-2-methoxy-Estra-1,3,5(10)-trien-17-one
362-08-3
genes like me logo Genes that share compounds with SHBG: view

Transcripts for SHBG Gene

Unigene Clusters for SHBG Gene

Sex hormone-binding globulin:
Representative Sequences:

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHBG Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1:
SP2: - -
SP3: -
SP4: - - -
SP5: -
SP6:

Relevant External Links for SHBG Gene

GeneLoc Exon Structure for
SHBG
ECgene alternative splicing isoforms for
SHBG

Expression for SHBG Gene

mRNA expression in normal human tissues for SHBG Gene

mRNA differential expression in normal tissues according to GTEx for SHBG Gene

This gene is overexpressed in Liver (x26.3) and Testis (x6.1).

Protein differential expression in normal tissues from HIPED for SHBG Gene

This gene is overexpressed in Serum (33.4), Plasma (12.0), Skin (8.7), and Synovial fluid (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SHBG Gene



NURSA nuclear receptor signaling pathways regulating expression of SHBG Gene:

SHBG

SOURCE GeneReport for Unigene cluster for SHBG Gene:

Hs.632235

mRNA Expression by UniProt/SwissProt for SHBG Gene:

P04278-SHBG_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are present in liver and testis.
genes like me logo Genes that share expression patterns with SHBG: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for SHBG Gene

Orthologs for SHBG Gene

This gene was present in the common ancestor of chordates.

Orthologs for SHBG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SHBG 34
  • 82.29 (n)
  • 75.06 (a)
SHBG 35
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SHBG 34
  • 81.51 (n)
  • 76.37 (a)
SHBG 35
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Shbg 34
  • 77.04 (n)
  • 67.28 (a)
Shbg 16
Shbg 35
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SHBG 34
  • 99.42 (n)
  • 99.25 (a)
SHBG 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Shbg 34
  • 77.4 (n)
  • 68.07 (a)
oppossum
(Monodelphis domestica)
Mammalia SHBG 35
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SHBG 35
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SHBG 35
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498622 34
  • 46.77 (n)
  • 34.24 (a)
zebrafish
(Danio rerio)
Actinopterygii shbg 34
  • 43.96 (n)
  • 33.12 (a)
shbg 35
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 11 (a)
ManyToMany
-- 35
  • 5 (a)
ManyToMany
Species where no ortholog for SHBG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHBG Gene

ENSEMBL:
Gene Tree for SHBG (if available)
TreeFam:
Gene Tree for SHBG (if available)

Paralogs for SHBG Gene

Paralogs for SHBG Gene

genes like me logo Genes that share paralogs with SHBG: view

Variants for SHBG Gene

Sequence variations from dbSNP and Humsavar for SHBG Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs6259 - 7,633,209(+) GAGAA(A/G)ACTCT downstream-variant-500B, reference, synonymous-codon, missense
rs6260 - 7,630,246(+) CACCC(A/G)CCAGG intron-variant, reference, missense, utr-variant-5-prime
rs6258 - 7,631,360(+) GTTGC(A/C/T)GGTAA reference, missense
rs9282845 - 7,630,237(+) ACTGC(A/G)TCACA intron-variant, reference, missense, utr-variant-5-prime
rs6257 -- 7,630,399(+) GTTTG(C/T)TTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SHBG Gene

Variant ID Type Subtype PubMed ID
dgv531e199 CNV deletion 23128226
esv2422288 CNV deletion 17116639
esv2715601 CNV deletion 23290073
esv3554089 CNV deletion 23714750
nsv1152811 CNV deletion 26484159
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781

Variation tolerance for SHBG Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.31; 53.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SHBG Gene

Human Gene Mutation Database (HGMD)
SHBG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SHBG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHBG Gene

Disorders for SHBG Gene

MalaCards: The human disease database

(65) MalaCards diseases for SHBG Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
polycystic ovary syndrome
  • multicystic ovaries
anovulation
androgenic alopecia
  • androgenetic alopecia
ovarian disease
  • ovarian dysfunction
hyperandrogenism
  • hyperandrogenization syndrome
- elite association - COSMIC cancer census association via MalaCards
Search SHBG in MalaCards View complete list of genes associated with diseases

Relevant External Links for SHBG

Genetic Association Database (GAD)
SHBG
Human Genome Epidemiology (HuGE) Navigator
SHBG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SHBG
genes like me logo Genes that share disorders with SHBG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SHBG Gene

Publications for SHBG Gene

  1. Polymorphisms of estrogen-related genes jointly confer susceptibility to human spermatogenic defect. (PMID: 18980759) Su M.T. … Kuo P.L. (Fertil. Steril. 2010) 3 22 46 65
  2. Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. (PMID: 19933169) Perry J.R. … Frayling T.M. (Hum. Mol. Genet. 2010) 3 22 46 65
  3. Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians. (PMID: 20432167) Iwasaki M. … Tsugane S. (Nutr Cancer 2010) 3 22 46 65
  4. Polymorphisms of the SHBG gene contribute to the interindividual variation of sex steroid hormone blood levels in young, middle-aged and elderly men. (PMID: 18681858) Vanbillemont G. … Kaufman J.M. (Clin. Endocrinol. (Oxf) 2009) 3 22 46 65
  5. Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer. (PMID: 19015200) Freedman N.D. … Abnet C.C. (Carcinogenesis 2009) 3 22 46 65

Products for SHBG Gene

Sources for SHBG Gene

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