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SHBG Gene

protein-coding GIFtS: 62

GC17P007472

sex hormone-binding globulin
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ABP ^¹, ², ³, ⁵
MGC126834 ^¹, ²
MGC138391 ^¹, ²
OTTHUMP00000135293 ^²
SBP ^², ³
TEBG ^¹, ²
TeBG ^³

Descriptions
Sex steroid-binding protein ^², ³
Testis-specific androgen-binding protein ^², ³
Testosterone-estradiol-binding globulin ^², ³
Testosterone-estrogen-binding globulin ^², ³
androgen binding protein ^²
sex hormone-binding globulin ^²
testosterone-binding beta-globulin ^²

External Ids
HGNC: 10839¹
Entrez Gene: 6462²
UniProtKB: P04278³
Ensembl: ENSG00000129214⁷

Search outside databases for aliases for SHBG gene

Previous GC identifers: GC17P007947 GC17P008273 GC17P007474 GC17P007734 GC17P007731

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SHBG:

This gene encodes a steroid binding protein that was first described as a plasma protein secreted

by the liver but is now thought to participate in the regulation of steroid responses. The encoded

protein binds each steroid molecule as a dimer formed from identical or nearly identical monomers.

The use of alternate promoters and alternatively spliced transcripts have been described. Multiple

transcript variants encoding different isoforms have been found for this gene. [provided by

RefSeq]

UniProtKB/Swiss-Prot: SHBG_HUMAN, P04278

Function: Functions as an androgen transport protein, but may also be involved in receptor mediated

processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone,

testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid

hormones by controlling their plasma concentration

Gene Wiki entry for SHBG (Sex_hormone-binding_globulin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SHBG gene

Entrez Gene cytogenetic band: 17p13-p12 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17pter-p12

SHBG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P007472: (about GC identifiers)

Start:	7,472,099 bp from pter
End:	7,477,420 bp from pter
Size:	5,322 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010718.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SHBG_HUMAN, P04278 (See protein sequence)

Recommended Name: Sex hormone-binding globulin precursor

Size: 402 amino acids; 43779 Da

Subunit: Homodimer

Subcellular location: Secreted (By similarity). Note=In testis, it is synthesized by the Sertoli

cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis (By

similarity)

PDB structures from and Proteopedia :

1D2S (3D)

1F5F (3D)

1KDK (3D)

1KDM (3D)

1LHN (3D)

1LHO (3D)

1LHU (3D)

1LHV (3D)

1LHW (3D)

Secondary accessions: P14689 Q16616 Q3MIL0 Q6ISD2

Alternative splicing: 2 isoforms: P04278-1 P04278-2 (Additional isoforms seem to exist)

REFSEQ proteins (4 alternative transcripts):

NP_001031.2 NP_001139751.1 NP_001139752.1 NP_001139753.1

ENSEMBL proteins:

ENSP00000369816 ENSP00000345675

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for SHBG
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Sex Hormone Binding Globulin)
	Human Recombinant Proteins from Abnova (SHBG)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	14718574

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Antibodies for SHBG:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for SHBG
	R&D Systems Antibodies for SHBG
	Antibodies from Abcam (Sex Hormone Binding Globulin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SHBG)
	Novus Biologicals Antibodies for SHBG

Assays for SHBG:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P04278

ProtoNet protein and cluster: P04278

2 Blocks protein families:

IPB001791 Laminin G

IPB012679 Laminin G

UniProtKB/Swiss-Prot: SHBG_HUMAN, P04278

Similarity: Contains 2 laminin G-like domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SHBG)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SHBG)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001040

Applied Biosystems Silencer® siRNAs for SHBG

Sigma-Aldrich siRNA and siRNA Panels for SHBG

Sigma-Aldrich shRNA for SHBG

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001040
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001040
untagged cDNA clone in CMV expression vector: NM_001040

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001040

UniProtKB/Swiss-Prot: SHBG_HUMAN, P04278

Function: Functions as an androgen transport protein, but may also be involved in receptor mediated

processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone,

testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid

hormones by controlling their plasma concentration

Genatlas biochemistry entry for SHBG:

sex hormone-binding globulin gene

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005497	androgen binding	TAS	2587256
GO:0042803	protein homodimerization activity	NAS	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for SHBG (Your Favorite Gene powered by Ingenuity)

Androgen Signaling

GeneDecks SHBG for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for SHBG

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009914	hormone transport	NAS	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for SHBG:

Antagonist

Browse Tocris compounds for SHBG
10/26 Novoseek chemical compound relationships for SHBG gene (see all 26 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dehydroepiandrosterone sulfate	94.73	556	16734850 (5), 11239541 (4), 14557441 (3), 1386249 (3) (see all 99)
androstenedione	93.62	386	16734850 (5), 10421267 (4), 19191727 (4), 15126802 (4) (see all 99)
estradiol	91.64	922	8593818 (8), 11165037 (7), 8388711 (6), 16700004 (5) (see all 99)
17-hydroxyprogesterone	84.22	72	10368794 (2), 7586599 (2), 16691383 (2), 15672938 (2) (see all 59)
dhea	83.31	203	8548945 (4), 17126492 (3), 7962322 (3), 11507679 (3) (see all 99)
3-alpha-androstanediol glucuronide	81.28	23	2177625 (2), 11214820 (1), 11397855 (1), 15970897 (1) (see all 14)
steroid	80.15	320	7880817 (6), 12814993 (4), 7626508 (4), 11457864 (4) (see all 99)
progesterone	70.22	172	8540288 (4), 9408086 (4), 17364602 (4), 2324243 (3) (see all 99)
glucose	66.06	292	7693380 (5), 11231984 (4), 16492215 (4), 11925670 (4) (see all 99)
equol	65.63	11	8545857 (2), 15213709 (2), 10868692 (2), 8594308 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SHBG)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SHBG)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001040

Sigma-Aldrich siRNA and siRNA Panels for SHBG

Sigma-Aldrich shRNA for SHBG

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001040

REFSEQ mRNAs for SHBG gene (4 alternative transcripts):

NM_001040.3 NM_001146279.1 NM_001146280.1 NM_001146281.1

NM_001040

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001040
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001040
                                 untagged cDNA clone in CMV expression vector: NM_001040

Additional cDNA sequence:

AK302603.1 BC069597.1 BC101785.1 BC112186.1 EU352656.1 EU352657.1 EU352658.1 EU352659.1

EU352660.1 EU352661.1 EU352662.1 EU352663.1 EU352664.1 EU352665.1 EU352666.1 EU352667.1

EU352668.1 EU352669.1 EU352670.1 EU352671.1 EU352672.1 EU352673.1 EU352674.1 EU352675.1

EU352676.1 X05403.1 X05792.1 X05885.1 X16351.1

5 DOTS entries:

DT.442592 DT.101982489 DT.101982491 DT.101982490 DT.97836861

24/25 AceView cDNA sequences (see all 25 ):

BC069597 CD013958 NM_001040 CD013957 X16351 CD013956 AA969124 CD013955

BX112186 AA644446 BV180022 AI056852 BM679842 X05792 BQ186441 X05403

X05885 AV655245 BF920941 T69271 W90612 AW949828 T29669 T69346

highest scoring ESTs for SHBG:

AA969124 AI056852 BC069597 BM679842 T69271 W90612 X05403 X05792 X05885 X16351

Unigene Cluster for SHBG:

Sex hormone-binding globulin

Hs.632235 [show with all ESTs]

Unigene Representative Sequence: CD013956

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SHBG (see all 6 )

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7	^	8	^	9
SP1:
SP2:											-		-
SP3:																	-
SP4:			-		-																		-
SP5:																							-

About this scheme

ECgene alternative splicing isoforms for SHBG

2 Ensembl transcripts including schematic representations:

ENST00000380450 ENST00000340624

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SHBG expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SHBG

¹ / ² / ³

3 probe-sets matching SHBG gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36328_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M31651	0.20	1.00	0.72	1
215689_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI056852	0.80	1.00	0.91	1
215689_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.632235
Expression variation in blood from EXPOLDB for SHBG
UniProtKB/Swiss-Prot: SHBG_HUMAN, P04278
Tissue specificity: Isoforms 1 and 2 are present in liver and testis

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SHBG gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SHBG¹	--	sex hormone-binding globulin	81.51(n) 76.37(a)	479487 XM_536625.2 XP_536625.1
chimpanzee (Pan troglodytes)	SHBG¹	--	sex hormone-binding globulin	99.42(n) 99.25(a)	455215 XM_511958.2 XP_511958.2
cow (Bos taurus)	SHBG¹	--	sex hormone-binding globulin	82.21(n) 75.06(a)	404182 XM_584958.3 XP_584958.3
rat (Rattus norvegicus)	Shbg¹	--	sex hormone binding globulin	77.04(n) 68.37(a)	24775 NM_012650.1 NP_036782.1
mouse (Mus musculus)	Shbg^{1, 5}	11 (35.00 cM)⁵	sex hormone binding globulin^{1, 5}	76.2(n)¹ 66.67(a)¹	20415¹ NM_011367.1¹ NP_035497.1¹ AK010959⁵ BC120785⁵ (see all 7)

About this table Species with no ortholog for SHBG

ENSEMBL Gene Tree for SHBG

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SHBG gene

PROS1² GAS6² ENSG00000189002²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/22 NCBI SNPs in SHBG are shown (see all 22 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 28)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs6259^1,2	C,F,H	7477252(+)	`GAGAAG/AACTCT`	1	N/D	mis¹ ese³		15	MN CSAM EA EU WA NA	1480
--	rs9282845^1,2	C,F,H	7474280(+)	`ACTGCG/ATCACA`	1	H/R	mis¹ ese³		9	MN CSAM EA EU WA	806
	rs6260^1,2	C,F,H	7474289(+)	`CACCCG/ACCAGG`	1	H/R	mis¹ ese³		15	MN CSAM EA EU WA	1516
	rs6258^1,2	C,F,H	7475403(+)	`GTTGCC/TGGTAA`	1	P/L	mis¹ ese³		13	MN CSAM EA EU WA	1238
	rs1799941^1,2	C,F	7474148(+)	`CACACG/ACAAGG`	1	--	ng5¹		5	MN CSAM EA	404
--	rs858516^1,2	F	7477823(-)	`ctctcA/Gagcag`	1	--	ng3¹		1	MN	184
	rs6261^1,2	C,F,H	7476809(+)	`TTGTCT/CTCTGG`	1	S/S	syn¹ ese³		10	MN CSAM EA EU WA	904
	rs4987212^1,2	C,F	7476884(+)	`TCCAGG/AGTGGT`	1	R/R	syn¹		6	MN CSAM EA NA	476
--	rs9282846^1,2	F	7474467(+)	`GCCCAC/TGACCC`	1	H/H	syn¹ ese³		5	MN CSAM EA	408
	rs9913778^1,2	C,F,H	7474626(+)	`CCTGTC/TTTCCT`	1	--	int¹ trp³		5	EU EA WA NA	542

About this table

HapMap Linkage Disequilibrium images for SHBG (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 182205

10/94 Novoseek disease relationships for SHBG gene (see all 94 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
polycystic ovary syndrome	92.52	57	12679434 (3), 1898744 (2), 1358841 (2), 14671199 (2) (see all 36)
hyperandrogenism	90.71	36	11927624 (3), 11012575 (2), 17628912 (2), 9440471 (2) (see all 28)
androgen deficiency	81.47	9	16151758 (1), 12755998 (1), 12007895 (1), 18922158 (1) (see all 6)
polycystic ovaries	79.65	11	1358841 (1), 15059163 (1), 15117902 (1), 8277481 (1) (see all 7)
insulin resistance	79.64	182	18949680 (5), 14557472 (4), 12212367 (4), 12679434 (4) (see all 99)
hypogonadism	79.60	15	8552218 (1), 18465688 (1), 15531498 (1), 16006729 (1) (see all 11)
insulin sensitivity	75.29	107	9004106 (6), 9632121 (6), 7593430 (5), 2292238 (3) (see all 54)
anovulation	74.71	6	10997613 (1), 8773746 (1), 15145973 (1), 11117666 (1) (see all 6)
hyperinsulinemia	72.63	43	1898744 (2), 8405515 (2), 10870035 (2), 7561622 (2) (see all 37)
endocrine effects	71.28	3	15350181 (1), 11148232 (1), 15672938 (1)

About this table

Human Gene Mutation Database: SHBG
Genetic Association Database: SHBG
Human Genome Epidemiology Navigator: SHBG (67 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1402 PubMed articles for SHBG gene (see all 1402 ):

Characterization of the human sex hormone binding globulin (SHBG) gene and demonstration of two transcripts in both liver and testis. (PubMed id 2587256)^{2, 3, 4} Gershagen S.... Fernlund P. (1989)
Influence of SHBG gene pentanucleotide TAAAA repeat and D327N polymorphism on serum sex hormone-binding globulin concentration in hirsute women. (PubMed id 14764814)^{1, 3, 6} Cousin P....Pugeat M. (2004)
Common genetic variation in the sex steroid hormone-binding globulin (SHBG) gene and circulating shbg levels among postmenopausal women: the Multiethnic Cohort. (PubMed id 15634719)^{1, 3, 6} Haiman C.A....Le Marchand L. (2005)
[Study on the (TAAAA)n repeat polymorphism in sex hormone-binding globulin gene and the SHBG serum levels in putative association with the glucose metabolic status of Chinese patients suffering from polycystic ovarian syndrome in Shandong province.] (PubMed id 16331562)^{1, 3, 6} Zhao J.L....Shi Y.H. (2005)
Association of the (TAAAA)n repeat polymorphism in the sex hormone-binding globulin (SHBG) gene with polycystic ovary syndrome and relation to SHBG serum levels. (PubMed id 14671199)^{1, 3, 6} Xita N....Georgiou I. (2003)
Molecular analyses of a human sex hormone-binding globulin variant: evidence for an additional carbohydrate chain. (PubMed id 1400872)^{1, 3, 4} Power S.G.A.... Hammond G.L. (1992)
Phytoestrogen exposure correlation with plasma estradiol in postmenopausal women in European Prospective Investigation of Cancer and Nutrition-Norfolk may involve diet-gene interactions. (PubMed id 15668497)^{1, 3, 6} Low Y.L....Bingham S.A. (2005)
Steroid ligands bind human sex hormone-binding globulin in specific orientations and produce distinct changes in protein conformation. (PubMed id 12065592)^{1, 3, 4} Grishkovskaya I....Muller Y.A. (2002)
Association of breast cancer risk with a common functional polymorphism (Asp327Asn) in the sex hormone-binding globulin gene. (PubMed id 15894658)^{1, 3, 6} Cui Y....Zheng W. (2005)
Polymorphisms associated with circulating sex hormone levels in postmenopausal women. (PubMed id 15199113)^{1, 3, 6} Dunning A.M....Ponder B.A. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6462	HGNC: 10839	AceView: SHBG	Ensembl:ENSG00000129214	euGenes: HUgn6462
ECgene: SHBG	H-InvDB: SHBG

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for SHBG	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Androgen-binding_protein

Licensable Technologies for SHBG
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for SHBG:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SHBG-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SHBG		Antibodies for SHBG
	Explore super-pooled esiRNAs		Proteins for SHBG
	Lentivirus-delivered shRNAs for SHBG		Small molecules for SHBG
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (SHBG)
	Antibodies (SHBG)
	Chimera RNAi (SHBG)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Sex Hormone Binding Globulin)
	Antibodies (Sex Hormone Binding Globulin)

Search OriGene for SHBG

Search Tocris compounds for SHBG

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Antibodies for SHBG

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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SHBG Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for SHBG

Summaries
for SHBG

Genomic Location
for SHBG

Proteins
for SHBG

Protein Domains/
Families
for SHBG

Gene Function
for SHBG

Pathways & Interactions
for SHBG

Drugs & Compounds
for SHBG

Transcripts
for SHBG

Expression
for SHBG

Orthologs
for SHBG

Paralogs
for SHBG

SNPs/Variants
for SHBG

Disorders & Mutations
for SHBG

Medical News
for SHBG

Publications
for SHBG

Search for SHBG

Genome Databases showing SHBG

Other Databases showing SHBG

Specialized Databases showing SHBG

Licensable Technologies
for SHBG

Services
for SHBG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SHBG Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor SHBG

Summariesfor SHBG

Genomic Locationfor SHBG

Proteinsfor SHBG

Protein Domains/Familiesfor SHBG

Gene Functionfor SHBG

Pathways & Interactionsfor SHBG

Drugs & Compoundsfor SHBG

Transcriptsfor SHBG

Expression for SHBG

Orthologsfor SHBG

Paralogsfor SHBG

SNPs/Variantsfor SHBG

Disorders & Mutationsfor SHBG

Medical Newsfor SHBG

Publicationsfor SHBG

Search for SHBG

Genome Databases showing SHBG

Other Databases showing SHBG

Specialized Databases showing SHBG

Licensable Technologiesfor SHBG

Servicesfor SHBG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SHBG

Summaries
for SHBG

Genomic Location
for SHBG

Proteins
for SHBG

Protein Domains/
Families
for SHBG

Gene Function
for SHBG

Pathways & Interactions
for SHBG

Drugs & Compounds
for SHBG

Transcripts
for SHBG

Expression
for SHBG

Orthologs
for SHBG

Paralogs
for SHBG

SNPs/Variants
for SHBG

Disorders & Mutations
for SHBG

Medical News
for SHBG

Publications
for SHBG

Licensable Technologies
for SHBG

Services
for SHBG