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SHBG Gene

protein-coding   GIFtS: 63
GCID: GC17P007523

Sex Hormone-Binding Globulin

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sex Hormone-Binding Globulin1 2     SBP2 3
ABP2 3 5     Androgen Binding Protein1
Sex Steroid-Binding Protein2 3     TEBG2
Testis-Specific Androgen-Binding Protein2 3     Testosterone-Binding Beta-Globulin2
Testosterone-Estradiol-Binding Globulin2 3     TeBG3
Testosterone-Estrogen-Binding Globulin2 3     

External Ids:    HGNC: 108391   Entrez Gene: 64622   Ensembl: ENSG000001292147   OMIM: 1822055   UniProtKB: P042783   

Export aliases for SHBG gene to outside databases

Previous GC identifers: GC17P007947 GC17P008273 GC17P007474 GC17P007734 GC17P007731 GC17P007472 GC17P007535 GC17P007413 GC17P007519


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SHBG Gene:
This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but
is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens
and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical
monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes
mellitus. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jan 2014)

GeneCards Summary for SHBG Gene:
SHBG (sex hormone-binding globulin) is a protein-coding gene. Diseases associated with SHBG include androgenic alopecia, and hypoactive sexual desire disorder. GO annotations related to this gene include androgen binding and protein homodimerization activity. An important paralog of this gene is PROS1.

UniProtKB/Swiss-Prot: SHBG_HUMAN, P04278
Function: Functions as an androgen transport protein, but may also be involved in receptor mediated processes.
Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and
17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma
concentration

Gene Wiki entry for SHBG (Sex hormone-binding globulin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SHBG gene promoter:
         COUP-TF1   PPAR-gamma1   COUP-TF   COUP   PPAR-gamma2   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSHBG promoter sequence
   Search Chromatin IP Primers for SHBG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SHBG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

SHBG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHBG gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007523:  view genomic region     (about GC identifiers)

Start:
7,517,382 bp from pter      End:
7,536,700 bp from pter
Size:
19,319 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SHBG_HUMAN, P04278 (See protein sequence)
Recommended Name: Sex hormone-binding globulin precursor  
Size: 402 amino acids; 43779 Da
Subunit: Homodimer
Sequence caution: Sequence=CAA29309.1; Type=Frameshift; Positions=47, 52, 54;
Selected PDB 3D structures from and Proteopedia for SHBG (see all 9):
1D2S (3D)        1F5F (3D)        1KDK (3D)        1KDM (3D)        1LHN (3D)        1LHO (3D)    
Secondary accessions: B0FWH4 E9PGW1 F5H5Z8 I3L1N7 P14689 Q16616 Q3MIL0 Q6ISD2
Alternative splicing: 5 isoforms:  P04278-1   P04278-2   P04278-3   P04278-4   P04278-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SHBG: NX_P04278

Explore proteomics data for SHBG at MOPED

Post-translational modifications: 

  • Variant Asn-356 contains one N-linked (GlcNAc...) at position 3561
  • Glycosylation2 at Thr36, Asn380, Asn396

  • See SHBG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_001031.2  NP_001139751.1  NP_001139752.1  NP_001139753.1  NP_001276042.1  NP_001276043.1  NP_001276044.1  NP_001276045.1  

    ENSEMBL proteins: 
     ENSP00000458816   ENSP00000458181   ENSP00000459620   ENSP00000458559   ENSP00000458875  
     ENSP00000459999   ENSP00000461133   ENSP00000458719   ENSP00000369816   ENSP00000461162  
     ENSP00000458199   ENSP00000388867   ENSP00000458973   ENSP00000460219   ENSP00000458858  
     ENSP00000459826   ENSP00000461743   ENSP00000393426   ENSP00000345675  

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    Cloud-Clone Corp. CLIAs for SHBG


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR013320 ConA-like_subgrp
     IPR001791 Laminin_G
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry P04278

    ProtoNet protein and cluster: P04278

    2 Blocks protein domains:
    IPB001791 Laminin G
    IPB012679 Laminin G


    UniProtKB/Swiss-Prot: SHBG_HUMAN, P04278
    Similarity: Contains 2 laminin G-like domains


    SHBG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SHBG_HUMAN, P04278
    Function: Functions as an androgen transport protein, but may also be involved in receptor mediated processes.
    Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and
    17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma
    concentration

         Genatlas biochemistry entry for SHBG:
    sex hormone-binding globulin gene

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005497androgen binding TAS2587256
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity ----
         
    SHBG for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SHBG:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SHBG
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SHBG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SHBG

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    hsa-mir-10a-5p (MIRT047620)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SHBG_HUMAN, P04278: Secreted (By similarity). Note=In testis, it is synthesized by the Sertoli cells, secreted
    into the lumen of the seminiferous tubule and transported to the epididymis (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol3
    nucleus2
    plasma membrane2
    endosome1
    golgi apparatus1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574

    SHBG for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SHBG About    
    See pathways by source

    SuperPathContained pathways About
    1Androgen Signaling
    Androgen Signaling0.52
    2Nongenotropic Androgen signaling
    Nongenotropic Androgen signaling

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SHBG
        Androgen Signaling

    1 BioSystems Pathway for SHBG
        Nongenotropic Androgen signaling


        Pathway & Disease-focused RT2 Profiler PCR Array including SHBG: 
              Prostate Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SHBG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SHBG (P042783 ENSP000003698164) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000232280O759553, ENSP000003914384I2D: score=3 STRING: ENSP00000391438
    FLOT1O759553, ENSP000003655694I2D: score=3 STRING: ENSP00000365569
    ENSG00000206379O759553I2D: score=3 
    ENSG00000206480O759553I2D: score=3 
    ENSG00000230143O759553I2D: score=3 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007285primary spermatocyte growth IEA--
    GO:0009914hormone transport ----

    SHBG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SHBG

    5 HMDB Compounds for SHBG    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Methoxyestrone2-(8S,9S,13S,14S)-3-hydroxy-2-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one (see all 7)362-08-33617115
    Danazol(17a)-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol (see all 16)17230-88-5--
    Estradiol(+)-3,17b-Estradiol (see all 83)50-28-2--
    Estrone(+)-Estrone (see all 7)53-16-7--
    Testosterone(+)-testosterone (see all 86)58-22-0--

    Selected DrugBank Compounds for SHBG (see all 13)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Estradiol17beta oestradiol (see all 7)50-28-2carrier--17201714 17435665 8530713 17171213 17274467 17258903 3521955
    EstropipateEstropipate (usp) (see all 4)7280-37-7carrier--17201714 17435665 8530713 17171213 17274467 17258903 3521955
    Danazol-- 17230-88-5carrier--2142109 2486535 3304725 2531153 12222988
    Hydrocortisone11beta-Hydroxycortisone (see all 16)50-23-7carrier--17494102 16912126 17628912 17507833 17270355
    5-Alpha-Androstane-3-Beta,17-Alpha-Diol-- --carrier--17139284 17016423 10592235
    5-Alpha-Androstane-3-Beta,17beta-Diol-- 571-20-0carrier--17139284 17016423 10592235
    FluoxymesteroneAndrofluorene (see all 8)76-43-7carrier--947929 6439037 7195405
    Dihydrotestosterone(5a,17b)-17-Hydroxyandrostan-3-one (see all 17)521-18-6carrier--14622020 12957668
    DrostanoloneDrolban (see all 2)58-19-5carrier--17139284 17016423
    Mitotane-- 53-19-0carrier--1903011 16551731

    Selected Novoseek inferred chemical compound relationships for SHBG gene (see all 124)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    testosterone 95.5 3743 15807883 (13), 15509641 (9), 9045129 (8), 9761253 (8) (see all 99)
    dehydroepiandrosterone sulfate 94.7 592 16734850 (5), 11239541 (4), 14557441 (3), 1386249 (3) (see all 99)
    androstenedione 93.5 400 16734850 (5), 10421267 (4), 19191727 (4), 15126802 (4) (see all 99)
    estradiol 91.9 1008 8593818 (8), 11165037 (7), 8388711 (6), 16700004 (5) (see all 99)
    estrone 87.4 157 12672036 (3), 8664410 (2), 10067812 (2), 15001617 (2) (see all 99)
    dihydrotestosterone 86.1 265 14622020 (5), 7962322 (4), 2362451 (3), 19394598 (3) (see all 99)
    17-hydroxyprogesterone 84 73 10368794 (2), 7586599 (2), 16691383 (2), 15672938 (2) (see all 60)
    dhea 83.3 210 8548945 (4), 17126492 (3), 7962322 (3), 11507679 (3) (see all 99)
    3-alpha-androstanediol glucuronide 82.8 26 2177625 (2), 11214820 (1), 11397855 (1), 20166103 (1) (see all 17)
    steroid 80.6 342 7880817 (6), 12814993 (4), 7626508 (4), 11457864 (4) (see all 99)



    SHBG for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SHBG gene (8 alternative transcripts): 
    NM_001040.4  NM_001146279.2  NM_001146280.2  NM_001146281.2  NM_001289113.1  NM_001289114.1  NM_001289115.1  NM_001289116.1  

    Unigene Cluster for SHBG:

    Sex hormone-binding globulin
    Hs.632235  [show with all ESTs]
    Unigene Representative Sequence: CD013956
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000572182(uc010cms.2) ENST00000574539(uc010cmu.2) ENST00000576728(uc010cmq.2)
    ENST00000575314(uc010cmt.2) ENST00000570547(uc010cmp.2) ENST00000572262(uc010cmo.2)
    ENST00000576478(uc010cmr.2) ENST00000575729 ENST00000380450(uc010cmy.2 uc002gie.2 uc010vue.1 uc010vuf.1 uc010cnc.2)
    ENST00000570527 ENST00000570353 ENST00000416273 ENST00000575903 ENST00000576830
    ENST00000571153 ENST00000575618 ENST00000576152 ENST00000576747

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      QuantiFast Probe-based Assays in human, mouse, rat SHBG

    Additional mRNA sequence: 

    AK302603.1 BC069597.1 BC101785.1 BC112186.1 EU352656.1 EU352657.1 EU352658.1 EU352659.1 
    EU352660.1 EU352661.1 EU352662.1 EU352663.1 EU352664.1 EU352665.1 EU352666.1 EU352667.1 
    EU352668.1 EU352669.1 EU352670.1 EU352671.1 EU352672.1 EU352673.1 EU352674.1 EU352675.1 
    EU352676.1 NR_027462.1 NR_027463.1 X05403.1 X05792.1 X05885.1 X16351.1 

    5 DOTS entries:

    DT.442592  DT.101982489  DT.101982491  DT.101982490  DT.97836861 

    Selected AceView cDNA sequences (see all 25):

    NM_001040 CD013958 AA969124 BX112186 BC069597 CD013955 CD013956 CD013957 
    X16351 X05403 BM679842 AA644446 AI056852 X05885 BV180022 BQ186441 
    X05792 AV655245 BF920941 AW949828 T69271 T29669 W90612 T69346 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SHBG (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:                                                                              
    SP2:                                -     -                                       
    SP3:                                                  -                           
    SP4:        -     -                                                     -         
    SP5:                                                                    -         


    ECgene alternative splicing isoforms for SHBG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SHBG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SHBG Expression
    About this image

    SHBG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SHBG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632235

    UniProtKB/Swiss-Prot: SHBG_HUMAN, P04278
    Tissue specificity: Isoform 1 and isoform 2 are present in liver and testis

        Pathway & Disease-focused RT2 Profiler PCR Array including SHBG: 
              Prostate Cancer in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHBG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SHBG gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Shbg1 , 5 sex hormone binding globulin1, 5 77.04(n)1
    67.28(a)1
      11 (42.86 cM)5
    204151  NM_011367.21  NP_035497.11 
     696148045 
    lizard
    (Anolis carolinensis)
    Reptilia SHBG6
    sex hormone-binding globulin
    37(a)
    1 ↔ 1
    GL343660.1(216876-222581)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004986221 growth arrest-specific protein 6-like 46.77(n)
    34.24(a)
      100498622  XM_002933338.2  XP_002933384.1 
    zebrafish
    (Danio rerio)
    Actinopterygii shbg1 sex hormone binding globulin 43.96(n)
    33.12(a)
      322604  NM_001007151.3  NP_001007152.1 


    ENSEMBL Gene Tree for SHBG (if available)
    TreeFam Gene Tree for SHBG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SHBG gene
    PROS12  GAS62  
    2 SIMAP similar genes for SHBG using alignment to 16 protein entries:     SHBG_HUMAN (see all proteins):
    PROS1    CNTNAP1

    SHBG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SHBG (see all 416)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1462686171,2
    --7518498(+) AGGCCA/GAGGCG 1 -- us2k10--------
    rs1480417901,2
    --7518503(+) GAGGCA/GGACGG 1 -- us2k10--------
    rs1926411541,2
    --7518513(+) GATCAC/TGAGAT 1 -- us2k10--------
    rs1831435951,2
    --7518514(+) ATCACA/GAGATC 1 -- us2k10--------
    rs1417472751,2
    --7518525(+) AGGAGC/TTGGAG 1 -- us2k10--------
    rs1505537511,2
    C--7518557(+) AAACAC/TCGTCT 1 -- us2k10--------
    rs1395216651,2
    C--7518612(+) AGCTAC/TTCGGG 1 -- us2k10--------
    rs1874306151,2
    C--7518646(+) GAACCC/TGTGAG 1 -- us2k10--------
    rs1126148381,2
    C--7518657(+) GCAGAG/TGTTGC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs3709388741,2
    C--7518718(+) TGTCT-/AAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SHBG (7517382 - 7536700 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SHBG:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715601CNV Deletion23290073
    dgv531e199CNV Deletion23128226
    esv2422288CNV Deletion17116639
    nsv457659CNV Loss19166990
    nsv907651CNV Loss21882294

    Human Gene Mutation Database (HGMD): SHBG
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SHBG
    DNA2.0 Custom Variant and Variant Library Synthesis for SHBG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182205    OMIM disorders: --

    Selected diseases for SHBG (see all 161):    
    About MalaCards
    androgenic alopecia    hypoactive sexual desire disorder    polycystic ovary syndrome    hyperandrogenism
    anovulation    ovarian disease    kwashiorkor    impotence
    androgen insensitivity syndrome    transsexualism    varicocele    subacute thyroiditis
    11-beta-hydroxylase deficiency    marasmus    gynecomastia    acanthosis nigricans
    46 xy gonadal dysgenesis    infantile onset spinocerebellar ataxia    acne    hypoadrenalism

    Selected diseases from the University of Copenhagen DISEASES database for SHBG (see all 24):
    Polycystic ovary syndrome     Hyperandrogenism     Hypogonadism     Breast cancer
    Anovulation     Sexual dysfunction     Hyperinsulinism     Amenorrhea
    Acne     Diabetes mellitus     Infertility     Prostate cancer
    Hypoactive sexual desire disorder     Gynecomastia     Osteoporosis     Acanthosis nigricans
    Hypothyroidism     Seborrheic dermatitis     Hyperthyroidism     Male infertility

    SHBG for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for SHBG gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polycystic ovary syndrome 92.4 62 12679434 (3), 1898744 (2), 1358841 (2), 16331562 (2) (see all 39)
    hyperandrogenism 90.8 38 11927624 (3), 11012575 (2), 20218317 (2), 9440471 (2) (see all 29)
    androgen deficiency 82 10 16151758 (1), 12755998 (1), 12007895 (1), 18922158 (1) (see all 7)
    insulin resistance 79.9 204 18949680 (5), 14557472 (4), 12212367 (4), 12679434 (4) (see all 99)
    hypogonadism 79.9 15 8552218 (1), 18465688 (1), 15531498 (1), 16006729 (1) (see all 11)
    polycystic ovaries 79.3 11 1358841 (1), 15059163 (1), 15117902 (1), 8277481 (1) (see all 7)
    insulin sensitivity 74.8 118 9004106 (6), 9632121 (6), 7593430 (5), 2292238 (3) (see all 58)
    anovulation 74.5 6 10997613 (1), 8773746 (1), 15145973 (1), 11117666 (1) (see all 6)
    hyperinsulinemia 72.8 44 1898744 (2), 8405515 (2), 10870035 (2), 7561622 (2) (see all 38)
    oligomenorrhea 70.6 1 12519843 (1)

    Genetic Association Database (GAD): SHBG
    Human Genome Epidemiology (HuGE) Navigator: SHBG (107 documents)

    Export disorders for SHBG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SHBG gene, integrated from 10 sources (see all 1802):
    (articles sorted by number of sources associating them with SHBG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human sex hormone binding globulin (SHBG) gene and demonstration of two transcripts in both liver and testis. (PubMed id 2587256)1, 2, 3 Gershagen S.... Fernlund P. (Nucleic Acids Res. 1989)
    2. Influence of SHBG gene pentanucleotide TAAAA repeat and D327N polymorphism on serum sex hormone-binding globulin concentration in hirsute women. (PubMed id 14764814)1, 4, 9 Cousin P....Pugeat M. (J. Clin. Endocrinol. Metab. 2004)
    3. Common genetic variation in the sex steroid hormone-binding globulin (SHBG) gene and circulating shbg levels among postmenopausal women: the Multiethnic Cohort. (PubMed id 15634719)1, 4, 9 Haiman C.A....Le Marchand L. (J. Clin. Endocrinol. Metab. 2005)
    4. Associations of serum sex hormone binding globulin (SHBG) levels with SHBG gene polymorphisms in the CARDIA Male Hormone Study. (PubMed id 18056923)1, 4, 9 Turk A....Gapstur S.M. (Am. J. Epidemiol. 2008)
    5. Identification of common variants in the SHBG gene affecting sex hormone-binding globulin levels and breast cancer risk in postmenopausal women. (PubMed id 19064566)1, 4, 9 Thompson D.J....Easton D.F. (amp 2008)
    6. Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. (PubMed id 19933169)1, 4, 9 Perry J.R....Frayling T.M. (Hum. Mol. Genet. 2010)
    7. Genetic polymorphisms are associated with serum levels of sex hormone binding globulin in postmenopausal women. (PubMed id 19091090)1, 4, 9 Riancho J.A....GonzA!lez-MacA-as J. (BMC Med. Genet. 2008)
    8. SHBG gene promoter polymorphisms in men are associated with serum sex hormone-binding globulin, androgen and androgen metabolite levels, and hip bone mineral density. (PubMed id 16926255)1, 4, 9 Eriksson A.L....Ohlsson C. (J. Clin. Endocrinol. Metab. 2006)
    9. [Study on the (TAAAA)n repeat polymorphism in sex hormone-binding globulin gene and the SHBG serum levels in putative association with the glucose metabolic status of Chinese patients suffering from polycystic ovarian syndrome in Shandong province]. (PubMed id 16331562)1, 4, 9 Zhao J.L....Shi Y.H. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2005)
    10. Association of the (TAAAA)n repeat polymorphism in the sex hormone-binding globulin (SHBG) gene with polycystic ovary syndrome and relation to SHBG serum levels. (PubMed id 14671199)1, 4, 9 Xita N....Georgiou I. (J. Clin. Endocrinol. Metab. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6462 HGNC: 10839 AceView: SHBG Ensembl:ENSG00000129214 euGenes: HUgn6462
    ECgene: SHBG H-InvDB: SHBG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SHBG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SHBG Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Androgen-binding_protein

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SHBG gene:
    Search GeneIP for patents involving SHBG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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