SHBG Gene
protein-coding GIFtS: 62
GCID: GC17P007519
|
|
sex hormone-binding globulin
| |
Aliases
for SHBG gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sex Hormone-Binding Globulin1 2 | | Testosterone-Estrogen-Binding Globulin2 3 | | ABP1 2 3 5 | | SBP2 3 | | TEBG1 2 | | MGC1268341 | | Sex Steroid-Binding Protein2 3 | | MGC1383911 | | Testis-Specific Androgen-Binding Protein2 3 | | Testosterone-Binding Beta-Globulin2 | | Testosterone-Estradiol-Binding Globulin2 3 | | TeBG3 |
Export aliases for SHBG gene to outside databasesPrevious GC identifers: GC17P007947 GC17P008273 GC17P007474 GC17P007734 GC17P007731 GC17P007472 GC17P007535 GC17P007413 |
Summaries
for SHBG gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SHBG:
This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but isnow thought to participate in the regulation of steroid responses. The encoded protein binds each steroid molecule asa dimer formed from identical or nearly identical monomers. The use of alternate promoters and alternatively splicedtranscripts have been described. Multiple transcript variants encoding different isoforms have been found for thisgene. (provided by RefSeq, Apr 2009)
UniProtKB/Swiss-Prot: SHBG_HUMAN, P04278Function: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Eachdimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol.Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration
Gene Wiki entry for SHBG (Sex hormone-binding globulin)
|
Genomic Views
for SHBG gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SHBG gene promoter:
COUP-TF1 PPAR-gamma1 COUP-TF COUP PPAR-gamma2 HNF-4alpha2 HNF-4alpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SHBG
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHBG |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13-p12 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17pter-p12SHBG Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P007519: view genomic region
(about GC identifiers)
Start:
|
7,517,382 bp from pter |
End:
|
7,536,700 bp from pter |
Size:
|
19,319 bases |
Orientation:
|
plus strand |
|
Proteins
for SHBG gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SHBG_HUMAN, P04278 (See
protein sequence)Recommended Name: Sex hormone-binding globulin precursor Size: 402 amino acids; 43779 Da
Subunit: Homodimer
Subcellular location: Secreted (By similarity). Note=In testis, it is synthesized by the Sertoli cells, secreted intothe lumen of the seminiferous tubule and transported to the epididymis (By similarity)
Sequence caution: Sequence=CAA29309.1; Type=Frameshift; Positions=47, 52, 54;
6/9 PDB 3D structures from  and Proteopedia  for SHBG (see all 9):1D2S (3D)
1F5F (3D)
1KDK (3D)
1KDM (3D)
1LHN (3D)
1LHO (3D)
Secondary accessions: B0FWH4 E9PGW1 F5H5Z8 I3L1N7 P14689 Q16616 Q3MIL0 Q6ISD2Alternative splicing: 5 isoforms: P04278-1 P04278-2 P04278-3 P04278-4 P04278-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SHBG: NX_P04278
Post-translational modifications:
Variant Asn-356 contains one N-linked (GlcNAc...) at position 3561
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P04278
SHBG Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001031.2 NP_001139751.1 NP_001139752.1 NP_001139753.1
ENSEMBL proteins: ENSP00000458816 ENSP00000458181 ENSP00000459620 ENSP00000458559 ENSP00000458875 ENSP00000459999 ENSP00000461133 ENSP00000458719 ENSP00000369816 ENSP00000461162 ENSP00000458199 ENSP00000388867 ENSP00000458973 ENSP00000460219 ENSP00000458858 ENSP00000459826 ENSP00000461743 ENSP00000393426 ENSP00000345675
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
SHBG for ontologies About GeneDecksing
SHBG Antibody Products:
Assay Products for SHBG: |
Protein
Domains /
Families
for SHBG gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SHBG for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P04278ProtoNet protein and cluster: P04278 2 Blocks protein families: IPB001791 Laminin G IPB012679 Laminin G
UniProtKB/Swiss-Prot: SHBG_HUMAN, P04278Similarity: Contains 2 laminin G-like domains |
Function
for SHBG gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SHBG_HUMAN, P04278Function: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Eachdimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol.Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration Genatlas biochemistry entry for SHBG:sex hormone-binding globulin gene
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SHBG (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SHBG (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): SHBG (NM_001040) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SHBG | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHBG |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHBG |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
SHBG for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SHBG:
|
Pathways & Interactions
for SHBG gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Nongenotropic Androgen signaling | | | 2 | Androgen Signaling | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SHBG
1  BioSystems Pathway for SHBG
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SHBG
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/79 Interacting proteins for SHBG (P042783 ENSP000003698164) via UniProtKB, MINT, STRING, and/or I2D (see all 79)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007285 | primary spermatocyte growth |
IEA | -- | | GO:0009914 | hormone transport |
NAS | -- |
SHBG for ontologies About GeneDecksing
|
Drugs & Compounds
for SHBG gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SHBG for compounds About GeneDecksing
 Browse Tocris compounds for SHBG
5 HMDB Compounds for SHBG About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| 2-Methoxyestrone | 2-(8S,9S,13S,14S)-3-hydroxy-2-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one (see all 7) | 362-08-3 | 3617115 | | Danazol | (17a)-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol (see all 16) | 17230-88-5 | -- | | Estradiol | (+)-3,17b-Estradiol (see all 83) | 50-28-2 | -- | | Estrone | (+)-Estrone (see all 7) | 53-16-7 | -- | | Testosterone | (+)-testosterone (see all 86) | 58-22-0 | -- |
10/12 DrugBank Compounds for SHBG (see all 12) About this table
10/124 Novoseek chemical compound relationships for SHBG gene (see all 124) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| testosterone |
95.5 |
3743 |
15807883 (13), 15509641 (9), 9045129 (8), 9761253 (8) (see all 99) |
| dehydroepiandrosterone sulfate |
94.7 |
592 |
16734850 (5), 11239541 (4), 14557441 (3), 1386249 (3) (see all 99) |
| androstenedione |
93.5 |
400 |
16734850 (5), 10421267 (4), 19191727 (4), 15126802 (4) (see all 99) |
| estradiol |
91.9 |
1008 |
8593818 (8), 11165037 (7), 8388711 (6), 16700004 (5) (see all 99) |
| estrone |
87.4 |
157 |
12672036 (3), 8664410 (2), 10067812 (2), 15001617 (2) (see all 99) |
| dihydrotestosterone |
86.1 |
265 |
14622020 (5), 7962322 (4), 2362451 (3), 19394598 (3) (see all 99) |
| 17-hydroxyprogesterone |
84 |
73 |
10368794 (2), 7586599 (2), 16691383 (2), 15672938 (2) (see all 60) |
| dhea |
83.3 |
210 |
8548945 (4), 17126492 (3), 7962322 (3), 11507679 (3) (see all 99) |
| 3-alpha-androstanediol glucuronide |
82.8 |
26 |
2177625 (2), 11214820 (1), 11397855 (1), 20166103 (1) (see all 17) |
| steroid |
80.6 |
342 |
7880817 (6), 12814993 (4), 7626508 (4), 11457864 (4) (see all 99) |
Search CenterWatch for drugs/clinical trials and news about SHBG
|
Transcripts
for SHBG gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SHBG gene (4 alternative transcripts): NM_001040.3 NM_001146279.1 NM_001146280.1 NM_001146281.1 Unigene Cluster for SHBG: Sex hormone-binding globulin Hs.632235 [show with all ESTs]Unigene Representative Sequence: CD01395618/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20): ENST00000572182(uc010cms.2) ENST00000574539(uc010cmu.2) ENST00000576728(uc010cmq.2)
ENST00000575314(uc010cmt.2) ENST00000570547(uc010cmp.2) ENST00000572262(uc010cmo.2)
ENST00000576478(uc010cmr.2) ENST00000575729 ENST00000380450(uc010cmy.2 uc002gie.2 uc010vue.1 uc010vuf.1 uc010cnc.2)
ENST00000570527 ENST00000570353 ENST00000416273 ENST00000575903 ENST00000576830
ENST00000571153 ENST00000575618 ENST00000576152 ENST00000576747
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SHBG (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SHBG (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): SHBG (NM_001040) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SHBG | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHBG |
Additional cDNA sequence: AK302603.1 BC069597.1 BC101785.1 BC112186.1 EU352656.1 EU352657.1 EU352658.1 EU352659.1 EU352660.1 EU352661.1 EU352662.1 EU352663.1 EU352664.1 EU352665.1 EU352666.1 EU352667.1 EU352668.1 EU352669.1 EU352670.1 EU352671.1 EU352672.1 EU352673.1 EU352674.1 EU352675.1 EU352676.1 NR_027462.1 NR_027463.1 X05403.1 X05792.1 X05885.1 X16351.1 5 DOTS entries: DT.442592 DT.101982489 DT.101982491 DT.101982490 DT.97836861 24/25 AceView cDNA sequences (see all 25): CD013957 BX112186 AA969124 CD013955 NM_001040 BC069597 CD013958 CD013956 X16351 BM679842 BQ186441 X05792 AI056852 X05885 X05403 AA644446 BV180022 BF920941 AV655245 T69271 T29669 W90612 AW949828 T69346
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SHBG (see all 6) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | - | | - | | | | | | | | | | | | | | | | | | - | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | - | | | |
ECgene alternative splicing isoforms for SHBG
|
Expression
for SHBG gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SHBG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SHBG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SHBG
SOURCE GeneReport for Unigene cluster: Hs.632235
UniProtKB/Swiss-Prot: SHBG_HUMAN, P04278Tissue specificity: Isoform 1 and isoform 2 are present in liver and testis
SABiosciences Expression via Pathway-Focused PCR Array including SHBG:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SHBG
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SHBG | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SHBG | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SHBG | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHBG |
Orthologs
for SHBG gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SHBG gene from 2/10 species (see all 10) About this table
ENSEMBL Gene Tree for SHBG (if available)
TreeFam Gene Tree for SHBG (if available) |
Paralogs
for SHBG gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SHBG gene
- PROS12 GAS62
2 SIMAP similar genes for SHBG using alignment to 16 protein entries: SHBG_HUMAN (see all proteins):PROS1 CNTNAP1
SHBG for paralogs About GeneDecksing
|
Genomic Variants
for SHBG gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SHBG (7517382 - 7536700 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SHBG: --
Human Gene Mutation Database (HGMD): SHBG
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SHBG |
|
Disorders
/ Diseases
for SHBG gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SHBG for disorders About GeneDecksing
OMIM gene information: 182205
OMIM disorders: --
20/177  diseases for SHBG (see all 177): About MalaCards11-beta-hydroxylase deficiency androgen insensitivity syndrome androgen insensitivity syndrome, partial 46 xy gonadal dysgenesis
open-angle glaucoma protein-energy malnutrition 21-hydroxylase deficiency acanthosis nigricans
gonadal dysgenesis infantile onset spinocerebellar ataxia primary open angle glaucoma retinol binding protein
seborrheic dermatitis hidradenitis suppurativa choroid plexus papilloma glucose intolerance
polycystic ovary syndrome short stature temporal lobe epilepsy pre-eclampsia
20/24 diseases from the University of Copenhagen DISEASES database for SHBG (see all 24):Polycystic ovary syndrome Hyperandrogenism Hypogonadism Anovulation
Breast cancer Amenorrhea Hyperinsulinism Sexual dysfunction
Infertility Diabetes mellitus Prostate cancer Osteoporosis
Gynecomastia Acanthosis nigricans Hypothyroidism Seborrheic dermatitis
Hyperthyroidism Klinefelter's syndrome Hypoactive sexual desire disorder Male infertility
10/94 Novoseek disease relationships for SHBG gene (see all 94) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| polycystic ovary syndrome |
92.4 |
62 |
12679434 (3), 1898744 (2), 1358841 (2), 16331562 (2) (see all 39) |
| hyperandrogenism |
90.8 |
38 |
11927624 (3), 11012575 (2), 20218317 (2), 9440471 (2) (see all 29) |
| androgen deficiency |
82 |
10 |
16151758 (1), 12755998 (1), 12007895 (1), 18922158 (1) (see all 7) |
| insulin resistance |
79.9 |
204 |
18949680 (5), 14557472 (4), 12212367 (4), 12679434 (4) (see all 99) |
| hypogonadism |
79.9 |
15 |
8552218 (1), 18465688 (1), 15531498 (1), 16006729 (1) (see all 11) |
| polycystic ovaries |
79.3 |
11 |
1358841 (1), 15059163 (1), 15117902 (1), 8277481 (1) (see all 7) |
| insulin sensitivity |
74.8 |
118 |
9004106 (6), 9632121 (6), 7593430 (5), 2292238 (3) (see all 58) |
| anovulation |
74.5 |
6 |
10997613 (1), 8773746 (1), 15145973 (1), 11117666 (1) (see all 6) |
| hyperinsulinemia |
72.8 |
44 |
1898744 (2), 8405515 (2), 10870035 (2), 7561622 (2) (see all 38) |
| oligomenorrhea |
70.6 |
1 |
12519843 (1) |
Genetic Association Database (GAD): SHBG
Human Genome Epidemiology (HuGE) Navigator: SHBG (107 documents)
Export disorders for SHBG gene to outside databases
|
Publications
for SHBG gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SHBG gene, integrated from 9 sources (see all 1770):
(articles sorted by number of sources associating them with SHBG) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of the human sex hormone binding globulin (SHBG) gene and demonstration of two transcripts in both liver and testis. (PubMed id 2587256)1, 2, 3 Gershagen S.... Fernlund P. (1989)
- Influence of SHBG gene pentanucleotide TAAAA repeat and D327N polymorphism on serum sex hormone-binding globulin concentration in hirsute women. (PubMed id 14764814)1, 4, 9 Cousin P....Pugeat M. (2004)
- Common genetic variation in the sex steroid hormone-binding globulin (SHBG) gene and circulating shbg levels among postmenopausal women: the Multiethnic Cohort. (PubMed id 15634719)1, 4, 9 Haiman C.A....Le Marchand L. (2005)
- [Study on the (TAAAA)n repeat polymorphism in sex hormone-binding globulin gene and the SHBG serum levels in putative association with the glucose metabolic status of Chinese patients suffering from polycystic ovarian syndrome in Shandong province.] (PubMed id 16331562)1, 4, 9 Zhao J.L....Shi Y.H. (2005)
- Association of the (TAAAA)n repeat polymorphism in the sex hormone-binding globulin (SHBG) gene with polycystic ovary syndrome and relation to SHBG serum levels. (PubMed id 14671199)1, 4, 9 Xita N....Georgiou I. (2003)
- Molecular analyses of a human sex hormone-binding globulin variant: evidence for an additional carbohydrate chain. (PubMed id 1400872)1, 2, 9 Power S.G.A.... Hammond G.L. (1992)
- Phytoestrogen exposure correlation with plasma estradiol in postmenopausal women in European Prospective Investigation of Cancer and Nutrition-Norfolk may involve diet-gene interactions. (PubMed id 15668497)1, 4, 9 Low Y.L....Bingham S.A. (2005)
- Steroid ligands bind human sex hormone-binding globulin in specific orientations and produce distinct changes in protein conformation. (PubMed id 12065592)1, 2, 9 Grishkovskaya I....Muller Y.A. (2002)
- Association of breast cancer risk with a common functional polymorphism (Asp327Asn) in the sex hormone-binding globulin gene. (PubMed id 15894658)1, 4, 9 Cui Y....Zheng W. (2005)
- Polymorphisms associated with circulating sex hormone levels in postmenopausal women. (PubMed id 15199113)1, 4, 9 Dunning A.M....Ponder B.A. (2004)
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External Searches for SHBG gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SHBG gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing SHBG gene
(According to HUGE)
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Specialized Databases showing SHBG gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for SHBG gene:
Search GeneIP for patents involving SHBG
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SHBG gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for SHBG | | OriGene shRNA RFP for SHBG | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SHBG | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SHBG | | | OriGene Protein Over-expression Lysate for SHBG | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SHBG | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SHBG | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SHBG | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SHBG | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SHBG | | OriGene Custom Protein Services for SHBG | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SHBG | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SHBG | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHBG | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SHBG | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SHBG | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SHBG |
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| | | | Search Tocris compounds for SHBG |
| |  |  |  |  | | | | | | Recombinant Protein for SHBG |
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 | | | SHBG Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHBG |
|  |  |  | | | | Search ThermoFisher Antibodies for SHBG |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHBG |
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