Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SHBG Gene

protein-coding   GIFtS: 63
GCID: GC17P007519

Sex Hormone-Binding Globulin

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sex Hormone-Binding Globulin1 2     SBP2 3
ABP2 3 5     Androgen Binding Protein1
Sex Steroid-Binding Protein2 3     TEBG2
Testis-Specific Androgen-Binding Protein2 3     Testosterone-Binding Beta-Globulin2
Testosterone-Estradiol-Binding Globulin2 3     TeBG3
Testosterone-Estrogen-Binding Globulin2 3     

External Ids:    HGNC: 108391   Entrez Gene: 64622   Ensembl: ENSG000001292147   OMIM: 1822055   UniProtKB: P042783   

Export aliases for SHBG gene to outside databases

Previous GC identifers: GC17P007947 GC17P008273 GC17P007474 GC17P007734 GC17P007731 GC17P007472 GC17P007535 GC17P007413


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SHBG Gene:
This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but
is now thought to participate in the regulation of steroid responses. The encoded protein binds each steroid
molecule as a dimer formed from identical or nearly identical monomers. The use of alternate promoters and
alternatively spliced transcripts have been described. Multiple transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Apr 2009)

GeneCards Summary for SHBG Gene: 
SHBG (sex hormone-binding globulin) is a protein-coding gene. Diseases associated with SHBG include androgen insensitivity syndrome, partial, and hypoactive sexual desire disorder, and among its related super-pathways are CCR5 Pathway in Macrophages. GO annotations related to this gene include androgen binding and protein homodimerization activity. An important paralog of this gene is PROS1.

UniProtKB/Swiss-Prot: SHBG_HUMAN, P04278
Function: Functions as an androgen transport protein, but may also be involved in receptor mediated processes.
Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and
17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma
concentration

Gene Wiki entry for SHBG (Sex hormone-binding globulin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SHBG gene promoter:
         COUP-TF1   PPAR-gamma1   COUP-TF   COUP   PPAR-gamma2   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSHBG promoter sequence
   Search SABiosciences Chromatin IP Primers for SHBG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHBG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

SHBG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHBG gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007519:  view genomic region     (about GC identifiers)

Start:
7,517,382 bp from pter      End:
7,536,700 bp from pter
Size:
19,319 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SHBG_HUMAN, P04278 (See protein sequence)
Recommended Name: Sex hormone-binding globulin precursor  
Size: 402 amino acids; 43779 Da
Subunit: Homodimer
Subcellular location: Secreted (By similarity). Note=In testis, it is synthesized by the Sertoli cells, secreted
into the lumen of the seminiferous tubule and transported to the epididymis (By similarity)
Sequence caution: Sequence=CAA29309.1; Type=Frameshift; Positions=47, 52, 54;
6/9 PDB 3D structures from and Proteopedia for SHBG (see all 9):
1D2S (3D)        1F5F (3D)        1KDK (3D)        1KDM (3D)        1LHN (3D)        1LHO (3D)    
Secondary accessions: B0FWH4 E9PGW1 F5H5Z8 I3L1N7 P14689 Q16616 Q3MIL0 Q6ISD2
Alternative splicing: 5 isoforms:  P04278-1   P04278-2   P04278-3   P04278-4   P04278-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SHBG: NX_P04278

Explore proteomics data for SHBG at MOPED 

Post-translational modifications:

  • UniProtKB: Variant Asn-356 contains one N-linked (GlcNAc...) at position 356
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P04278

  • SHBG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SHBG Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001031.2  NP_001139751.1  NP_001139752.1  NP_001139753.1  

    ENSEMBL proteins: 
     ENSP00000458816   ENSP00000458181   ENSP00000459620   ENSP00000458559   ENSP00000458875  
     ENSP00000459999   ENSP00000461133   ENSP00000458719   ENSP00000369816   ENSP00000461162  
     ENSP00000458199   ENSP00000388867   ENSP00000458973   ENSP00000460219   ENSP00000458858  
     ENSP00000459826   ENSP00000461743   ENSP00000393426   ENSP00000345675  

    Human Recombinant Protein Products for SHBG: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SHBG
    OriGene Protein Over-expression Lysate for SHBG
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SHBG
    GenScript Custom Purified and Recombinant Proteins Services for SHBG
    Novus Biologicals SHBG Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SHBG
    Cloud-Clone Corp. Proteins for SHBG 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574

    SHBG for ontologies           About GeneDecksing



    SHBG Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SHBG
    OriGene Antibodies for SHBG
    OriGene Custom Antibody Services for SHBG
    GenScript Custom Superior Antibodies Services for SHBG
    Novus Biologicals SHBG Antibodies
    Abcam antibodies for SHBG
    Cloud-Clone Corp. Antibodies for SHBG 
    ThermoFisher Antibodies for SHBG
    LSBio Antibodies in human, mouse, rat for SHBG 

    Assay Products for SHBG: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SHBG
    R&D Systems ELISAs for SHBG         (see all)
    GenScript Custom Assay Services for SHBG
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SHBG 
    Cloud-Clone Corp. CLIAs for SHBG


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR013320 ConA-like_subgrp
     IPR001791 Laminin_G
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry P04278

    ProtoNet protein and cluster: P04278

    2 Blocks protein domains:
    IPB001791 Laminin G
    IPB012679 Laminin G


    UniProtKB/Swiss-Prot: SHBG_HUMAN, P04278
    Similarity: Contains 2 laminin G-like domains


    SHBG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SHBG_HUMAN, P04278
    Function: Functions as an androgen transport protein, but may also be involved in receptor mediated processes.
    Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and
    17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma
    concentration

         Genatlas biochemistry entry for SHBG:
    sex hormone-binding globulin gene

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005497androgen binding TAS2587256
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity NAS--
         
    SHBG for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SHBG:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SHBG 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SHBG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SHBG 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SHBG 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SHBG
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SHBG
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SHBG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SHBG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SHBG
    Sirion Biotech Customized adenovirus for overexpression of SHBG

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SHBG (see all 21)
    OriGene ORF clones in mouse, rat for SHBG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): SHBG (NM_001040)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SHBG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHBG
    Sirion Biotech Customized lentivirus for stable overexpression of SHBG 
                         Customized lentivirus expression plasmids for stable overexpression of SHBG 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SHBG
    Search LifeMap BioReagents cell lines for SHBG
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHBG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SHBG About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Androgen Signaling
    Androgen Signaling0.52
    2Nongenotropic Androgen signaling
    Nongenotropic Androgen signaling

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SHBG
        Androgen Signaling

    1 BioSystems Pathway for SHBG
        Nongenotropic Androgen signaling


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SHBG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/83 Interacting proteins for SHBG (P042783 ENSP000003698164) via UniProtKB, MINT, STRING, and/or I2D (see all 83)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000232280O759553, ENSP000003914384I2D: score=3 STRING: ENSP00000391438
    FLOT1O759553, ENSP000003655694I2D: score=3 STRING: ENSP00000365569
    ENSG00000206379O759553I2D: score=3 
    ENSG00000206480O759553I2D: score=3 
    ENSG00000230143O759553I2D: score=3 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007285primary spermatocyte growth IEA--
    GO:0009914hormone transport NAS--

    SHBG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SHBG for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SHBG

    5 HMDB Compounds for SHBG    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Methoxyestrone2-(8S,9S,13S,14S)-3-hydroxy-2-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one (see all 7)362-08-33617115
    Danazol(17a)-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol (see all 16)17230-88-5--
    Estradiol(+)-3,17b-Estradiol (see all 83)50-28-2--
    Estrone(+)-Estrone (see all 7)53-16-7--
    Testosterone(+)-testosterone (see all 86)58-22-0--

    10/13 DrugBank Compounds for SHBG (see all 13)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Estradiol17beta oestradiol (see all 7)50-28-2carrier--17201714 17435665 8530713 17171213 17274467 17258903 3521955
    EstropipateEstropipate (usp) (see all 4)7280-37-7carrier--17201714 17435665 8530713 17171213 17274467 17258903 3521955
    Danazol-- 17230-88-5carrier--2142109 2486535 3304725 2531153 12222988
    Hydrocortisone11beta-Hydroxycortisone (see all 16)50-23-7carrier--17494102 16912126 17628912 17507833 17270355
    5-Alpha-Androstane-3-Beta,17-Alpha-Diol-- --carrier--17139284 17016423 10592235
    5-Alpha-Androstane-3-Beta,17beta-Diol-- 571-20-0carrier--17139284 17016423 10592235
    FluoxymesteroneAndrofluorene (see all 8)76-43-7carrier--947929 6439037 7195405
    Dihydrotestosterone(5a,17b)-17-Hydroxyandrostan-3-one (see all 17)521-18-6carrier--14622020 12957668
    DrostanoloneDrolban (see all 2)58-19-5carrier--17139284 17016423
    Mitotane-- 53-19-0carrier--1903011 16551731

    10/124 Novoseek inferred chemical compound relationships for SHBG gene (see all 124)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    testosterone 95.5 3743 15807883 (13), 15509641 (9), 9045129 (8), 9761253 (8) (see all 99)
    dehydroepiandrosterone sulfate 94.7 592 16734850 (5), 11239541 (4), 14557441 (3), 1386249 (3) (see all 99)
    androstenedione 93.5 400 16734850 (5), 10421267 (4), 19191727 (4), 15126802 (4) (see all 99)
    estradiol 91.9 1008 8593818 (8), 11165037 (7), 8388711 (6), 16700004 (5) (see all 99)
    estrone 87.4 157 12672036 (3), 8664410 (2), 10067812 (2), 15001617 (2) (see all 99)
    dihydrotestosterone 86.1 265 14622020 (5), 7962322 (4), 2362451 (3), 19394598 (3) (see all 99)
    17-hydroxyprogesterone 84 73 10368794 (2), 7586599 (2), 16691383 (2), 15672938 (2) (see all 60)
    dhea 83.3 210 8548945 (4), 17126492 (3), 7962322 (3), 11507679 (3) (see all 99)
    3-alpha-androstanediol glucuronide 82.8 26 2177625 (2), 11214820 (1), 11397855 (1), 20166103 (1) (see all 17)
    steroid 80.6 342 7880817 (6), 12814993 (4), 7626508 (4), 11457864 (4) (see all 99)

    Search CenterWatch for drugs/clinical trials and news about SHBG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SHBG gene (4 alternative transcripts): 
    NM_001040.3  NM_001146279.1  NM_001146280.1  NM_001146281.1  

    Unigene Cluster for SHBG:

    Sex hormone-binding globulin
    Hs.632235  [show with all ESTs]
    Unigene Representative Sequence: CD013956
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000572182(uc010cms.2) ENST00000574539(uc010cmu.2) ENST00000576728(uc010cmq.2)
    ENST00000575314(uc010cmt.2) ENST00000570547(uc010cmp.2) ENST00000572262(uc010cmo.2)
    ENST00000576478(uc010cmr.2) ENST00000575729 ENST00000380450(uc010cmy.2 uc002gie.2 uc010vue.1 uc010vuf.1 uc010cnc.2)
    ENST00000570527 ENST00000570353 ENST00000416273 ENST00000575903 ENST00000576830
    ENST00000571153 ENST00000575618 ENST00000576152 ENST00000576747

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SHBG
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SHBG
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SHBG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SHBG
    Clone
    Products:
         
    OriGene clones in human, mouse for SHBG (see all 21)
    OriGene ORF clones in mouse, rat for SHBG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): SHBG (NM_001040)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SHBG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHBG
    Sirion Biotech Customized lentivirus for stable overexpression of SHBG 
                         Customized lentivirus expression plasmids for stable overexpression of SHBG 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SHBG
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SHBG
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SHBG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SHBG

    Additional mRNA sequence: 

    AK302603.1 BC069597.1 BC101785.1 BC112186.1 EU352656.1 EU352657.1 EU352658.1 EU352659.1 
    EU352660.1 EU352661.1 EU352662.1 EU352663.1 EU352664.1 EU352665.1 EU352666.1 EU352667.1 
    EU352668.1 EU352669.1 EU352670.1 EU352671.1 EU352672.1 EU352673.1 EU352674.1 EU352675.1 
    EU352676.1 NR_027462.1 NR_027463.1 X05403.1 X05792.1 X05885.1 X16351.1 

    5 DOTS entries:

    DT.442592  DT.101982489  DT.101982491  DT.101982490  DT.97836861 

    24/25 AceView cDNA sequences (see all 25):

    BX112186 CD013955 NM_001040 AA969124 CD013957 X16351 CD013958 CD013956 
    BC069597 X05403 BV180022 BM679842 AA644446 X05885 BQ186441 X05792 
    AI056852 BF920941 AV655245 T69271 AW949828 W90612 T29669 T69346 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SHBG (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:                                                                              
    SP2:                                -     -                                       
    SP3:                                                  -                           
    SP4:        -     -                                                     -         
    SP5:                                                                    -         


    ECgene alternative splicing isoforms for SHBG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SHBG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SHBG Expression
    About this image


    See SHBG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SHBG

    SOURCE GeneReport for Unigene cluster: Hs.632235

    UniProtKB/Swiss-Prot: SHBG_HUMAN, P04278
    Tissue specificity: Isoform 1 and isoform 2 are present in liver and testis

        SABiosciences Expression via Pathway-Focused PCR Array including SHBG: 
              Prostate Cancer in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SHBG
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SHBG
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SHBG
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SHBG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHBG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SHBG gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Shbg1 , 5 sex hormone binding globulin1, 5 76.2(n)1
    66.67(a)1
      11 (42.86 cM)5
    204151  NM_011367.21  NP_035497.11 
     696148045 
    lizard
    (Anolis carolinensis)
    Reptilia SHBG6
    Uncharacterized protein
    33(a)
    1 ↔ 1
    GL343660.1(216876-222581)
    zebrafish
    (Danio rerio)
    Actinopterygii shbg1 sex hormone binding globulin 43.65(n)
    32.81(a)
      322604  NM_001007151.3  NP_001007152.1 


    ENSEMBL Gene Tree for SHBG (if available)
    TreeFam Gene Tree for SHBG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SHBG gene
    PROS12  GAS62  
    2 SIMAP similar genes for SHBG using alignment to 16 protein entries:     SHBG_HUMAN (see all proteins):
    PROS1    CNTNAP1

    SHBG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/416 SNPs in SHBG are shown (see all 416)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1462686171,2
    --7518498(+) AGGCCA/GAGGCG 1 -- us2k10--------
    rs1480417901,2
    --7518503(+) GAGGCA/GGACGG 1 -- us2k10--------
    rs1926411541,2
    --7518513(+) GATCAC/TGAGAT 1 -- us2k10--------
    rs1831435951,2
    --7518514(+) ATCACA/GAGATC 1 -- us2k10--------
    rs1417472751,2
    --7518525(+) AGGAGC/TTGGAG 1 -- us2k10--------
    rs1505537511,2
    C--7518557(+) AAACAC/TCGTCT 1 -- us2k10--------
    rs1395216651,2
    C--7518612(+) AGCTAC/TTCGGG 1 -- us2k10--------
    rs1874306151,2
    C--7518646(+) GAACCC/TGTGAG 1 -- us2k10--------
    rs1126148381,2
    C--7518657(+) GCAGAG/TGTTGC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs3709388741,2
    C--7518718(+) TGTCT-/AAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SHBG (7517382 - 7536700 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SHBG:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2715601CNV Deletion23290073
    dgv531e199CNV Deletion23128226
    esv2422288CNV Deletion17116639
    nsv457659CNV Loss19166990
    nsv907651CNV Loss21882294


    Human Gene Mutation Database (HGMD): SHBG
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SHBG
    DNA2.0 Custom Variant and Variant Library Synthesis for SHBG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 182205    OMIM disorders: --

    20/160 diseases for SHBG (see all 160):    About MalaCards
    androgen insensitivity syndrome, partial    hypoactive sexual desire disorder    polycystic ovary syndrome    hyperandrogenism
    anovulation    kwashiorkor    transsexualism    ovarian disease
    impotence    androgen insensitivity syndrome    androgenetic alopecia    varicocele
    subacute thyroiditis    marasmus    infantile onset spinocerebellar ataxia    acne
    osteoporotic fracture    gynecomastia    46 xy gonadal dysgenesis    hypoadrenalism

    20/24 diseases from the University of Copenhagen DISEASES database for SHBG (see all 24):
    Polycystic ovary syndrome     Hyperandrogenism     Hypogonadism     Breast cancer
    Anovulation     Sexual dysfunction     Hyperinsulinism     Amenorrhea
    Acne     Diabetes mellitus     Infertility     Prostate cancer
    Hypoactive sexual desire disorder     Gynecomastia     Osteoporosis     Acanthosis nigricans
    Hypothyroidism     Seborrheic dermatitis     Hyperthyroidism     Male infertility

    SHBG for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/94 Novoseek inferred disease relationships for SHBG gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polycystic ovary syndrome 92.4 62 12679434 (3), 1898744 (2), 1358841 (2), 16331562 (2) (see all 39)
    hyperandrogenism 90.8 38 11927624 (3), 11012575 (2), 20218317 (2), 9440471 (2) (see all 29)
    androgen deficiency 82 10 16151758 (1), 12755998 (1), 12007895 (1), 18922158 (1) (see all 7)
    insulin resistance 79.9 204 18949680 (5), 14557472 (4), 12212367 (4), 12679434 (4) (see all 99)
    hypogonadism 79.9 15 8552218 (1), 18465688 (1), 15531498 (1), 16006729 (1) (see all 11)
    polycystic ovaries 79.3 11 1358841 (1), 15059163 (1), 15117902 (1), 8277481 (1) (see all 7)
    insulin sensitivity 74.8 118 9004106 (6), 9632121 (6), 7593430 (5), 2292238 (3) (see all 58)
    anovulation 74.5 6 10997613 (1), 8773746 (1), 15145973 (1), 11117666 (1) (see all 6)
    hyperinsulinemia 72.8 44 1898744 (2), 8405515 (2), 10870035 (2), 7561622 (2) (see all 38)
    oligomenorrhea 70.6 1 12519843 (1)

    Genetic Association Database (GAD): SHBG
    Human Genome Epidemiology (HuGE) Navigator: SHBG (107 documents)

    Export disorders for SHBG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SHBG gene, integrated from 9 sources (see all 1791):
    (articles sorted by number of sources associating them with SHBG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human sex hormone binding globulin (SHBG) gene and demonstration of two transcripts in both liver and testis. (PubMed id 2587256)1, 2, 3 Gershagen S.... Fernlund P. (1989)
    2. Influence of SHBG gene pentanucleotide TAAAA repeat and D327N polymorphism on serum sex hormone-binding globulin concentration in hirsute women. (PubMed id 14764814)1, 4, 9 Cousin P....Pugeat M. (2004)
    3. Common genetic variation in the sex steroid hormone-binding globulin (SHBG) gene and circulating shbg levels among postmenopausal women: the Multiethnic Cohort. (PubMed id 15634719)1, 4, 9 Haiman C.A....Le Marchand L. (2005)
    4. Associations of serum sex hormone binding globulin (SHBG) levels with SHBG gene polymorphisms in the CARDIA Male Hormone Study. (PubMed id 18056923)1, 4, 9 Turk A....Gapstur S.M. (2008)
    5. Identification of common variants in the SHBG gene affecting sex hormone-binding globulin levels and breast cancer risk in postmenopausal women. (PubMed id 19064566)1, 4, 9 Thompson D.J....Easton D.F. (2008)
    6. Genetic evidence that raised sex hormone binding glob ulin (SHBG) levels reduce the risk of type 2 diabetes. (PubMed id 19933169)1, 4, 9 Perry J.R....Sampson M. (2010)
    7. Genetic polymorphisms are associated with serum levels of sex hormone binding globulin in postmenopausal women. (PubMed id 19091090)1, 4, 9 Riancho J.A....GonzA!lez-MacA-as J. (2008)
    8. SHBG gene promoter polymorphisms in men are associated with serum sex hormone-binding globulin, androgen and androgen metabolite levels, and hip bone mineral density. (PubMed id 16926255)1, 4, 9 Eriksson A.L....Ohlsson C. (2006)
    9. [Study on the (TAAAA)n repeat polymorphism in sex hormone-binding globulin gene and the SHBG serum levels in putative association with the glucose metabolic status of Chinese patients suffering from polycystic ovarian syndrome in Shandong province.] (PubMed id 16331562)1, 4, 9 Zhao J.L....Shi Y.H. (2005)
    10. Association of the (TAAAA)n repeat polymorphism in the sex hormone-binding globulin (SHBG) gene with polycystic ovary syndrome and relation to SHBG serum levels. (PubMed id 14671199)1, 4, 9 Xita N....Georgiou I. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6462 HGNC: 10839 AceView: SHBG Ensembl:ENSG00000129214 euGenes: HUgn6462
    ECgene: SHBG H-InvDB: SHBG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SHBG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SHBG Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Androgen-binding_protein

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SHBG gene:
    Search GeneIP for patents involving SHBG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for SHBG (SHBG)   Browse Cell Culture Products  
     ELISAs for SHBG (SHBG)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents for SHBG (SHBG)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for SHBG (SHBG)  
     OriGene Antibodies for SHBG   OriGene RNAi products in human, mouse, rat for SHBG  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SHBG  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SHBG  
     OriGene qSTAR qPCR primer pairs in human, mouse for SHBG   OriGene Purified Protein for SHBG  
     OriGene ORF clones in mouse, rat for SHBG   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SHBG   OriGene Custom Protein Services for SHBG  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SHBG
     QIAGEN SeqTarget long-range PCR primers for resequencing SHBG
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHBG
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SHBG
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SHBG
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SHBG
     GenScript Custom Purified and Recombinant Proteins Services for SHBG GenScript cDNA clones with any tag delivered in your preferred vector for SHBG
     GenScript Custom Assay Services for SHBG GenScript Custom Superior Antibodies Services for SHBG
     GenScript Custom overexpressing Cell Line Services for SHBG CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SHBG promoter
     Search Chromatin IP Primers for SHBG
     RT2 qPCR Primer Assay in human, mouse, rat SHBG
     GNC Network for SHBG
     SABiosciences PCR Arrays including human, mouse, rat SHBG
     Search Tocris compounds for SHBG
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SHBG antibodies
     SHBG proteins
     Antibodies for SHBG
     See all of Abcam's Antibodies, Kits and Proteins for SHBG
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for SHBG




     Proteins for SHBG
     Antibodies for SHBG
     ELISAs for SHBG
     CLIAs for SHBG
     Search LifeMap BioReagents cell lines for SHBG
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHBG
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SHBG
     SwitchGear Promoter luciferase reporter plasmids for SHBG
     ThermoFisher Antibodies for SHBG
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHBG
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SHBG
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SHBG
    Customized:
     lentivirus for stable overexpression of SHBG
     lentivirus expression plasmids for stable overexpression of SHBG
     adenovirus for overexpression of SHBG
     LSBio Antibodies in human, mouse, rat for SHBG
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SHBG gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4