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Aliases for SHBG Gene

Aliases for SHBG Gene

  • Sex Hormone-Binding Globulin 2 3
  • ABP 3 4 6
  • Testis-Specific Androgen-Binding Protein 3 4
  • Testosterone-Estradiol-Binding Globulin 3 4
  • Testosterone-Estrogen-Binding Globulin 3 4
  • Sex Steroid-Binding Protein 3 4
  • TEBG 3 4
  • SBP 3 4
  • Testosterone-Binding Beta-Globulin 3
  • Androgen Binding Protein 2

External Ids for SHBG Gene

Summaries for SHBG Gene

Entrez Gene Summary for SHBG Gene

  • This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for SHBG Gene

SHBG (Sex Hormone-Binding Globulin) is a Protein Coding gene. Diseases associated with SHBG include polycystic ovary syndrome and hypoactive sexual desire disorder. Among its related pathways are Nongenotropic Androgen signaling and Androgen Signaling. GO annotations related to this gene include protein homodimerization activity and androgen binding. An important paralog of this gene is GAS6.

UniProtKB/Swiss-Prot for SHBG Gene

  • Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration

Gene Wiki entry for SHBG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHBG Gene

Genomics for SHBG Gene

Genomic Location for SHBG Gene

Start:
7,613,946 bp from pter
End:
7,633,383 bp from pter
Size:
19,438 bases
Orientation:
Plus strand

Genomic View for SHBG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SHBG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHBG Gene

Regulatory Elements for SHBG Gene

Proteins for SHBG Gene

  • Protein details for SHBG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04278-SHBG_HUMAN
    Recommended name:
    Sex hormone-binding globulin
    Protein Accession:
    P04278
    Secondary Accessions:
    • B0FWH4
    • E9PGW1
    • F5H5Z8
    • I3L1N7
    • P14689
    • Q16616
    • Q3MIL0
    • Q6ISD2

    Protein attributes for SHBG Gene

    Size:
    402 amino acids
    Molecular mass:
    43779 Da
    Quaternary structure:
    • Homodimer
    SequenceCaution:
    • Sequence=CAA29309.1; Type=Frameshift; Positions=47, 52, 54; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SHBG Gene

    Alternative splice isoforms for SHBG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SHBG Gene

Proteomics data for SHBG Gene at MOPED

Post-translational modifications for SHBG Gene

  • Variant Asn-356 contains one N-linked (GlcNAc...) at position 356.
  • Glycosylation at Thr36, Asn380, and Asn396

No data available for DME Specific Peptides for SHBG Gene

Domains for SHBG Gene

Protein Domains for SHBG Gene

Graphical View of Domain Structure for InterPro Entry

P04278

UniProtKB/Swiss-Prot:

SHBG_HUMAN
Domain:
  • Contains 2 laminin G-like domains.:
    • P04278
genes like me logo Genes that share domains with SHBG: view

No data available for Gene Families for SHBG Gene

Function for SHBG Gene

Molecular function for SHBG Gene

GENATLAS Biochemistry: sex hormone-binding globulin gene
UniProtKB/Swiss-Prot Function: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration

Gene Ontology (GO) - Molecular Function for SHBG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005497 androgen binding TAS 2587256
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SHBG: view

Phenotypes for SHBG Gene

GenomeRNAi human phenotypes for SHBG:
genes like me logo Genes that share phenotypes with SHBG: view

miRNA for SHBG Gene

miRTarBase miRNAs that target SHBG

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SHBG Gene

Localization for SHBG Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHBG Gene

Secreted. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SHBG Gene COMPARTMENTS Subcellular localization image for SHBG gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 2
plasma membrane 2
endosome 1
golgi apparatus 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SHBG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SHBG: view

Pathways for SHBG Gene

genes like me logo Genes that share pathways with SHBG: view

Pathways by source for SHBG Gene

1 Qiagen pathway for SHBG Gene
1 BioSystems pathway for SHBG Gene

Gene Ontology (GO) - Biological Process for SHBG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007285 primary spermatocyte growth IEA --
genes like me logo Genes that share ontologies with SHBG: view

Compounds for SHBG Gene

(5) HMDB Compounds for SHBG Gene

Compound Synonyms Cas Number PubMed IDs
2-Methoxyestrone
  • 2-(8S,9S,13S,14S)-3-hydroxy-2-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
362-08-3
Danazol
  • (17a)-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol
17230-88-5
Estradiol
  • (+)-3,17b-Estradiol
50-28-2
Estrone
  • (+)-Estrone
53-16-7
Testosterone
  • (+)-testosterone
58-22-0

(13) Drugbank Compounds for SHBG Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
5-Alpha-Androstane-3-Beta,17-Alpha-Diol
carrier
5-Alpha-Androstane-3-Beta,17beta-Diol
571-20-0 carrier
Danazol
17230-88-5 carrier
Dihydrotestosterone
  • (5a,17b)-17-Hydroxyandrostan-3-one
521-18-6 carrier
Drostanolone
  • Drolban
58-19-5 carrier

(124) Novoseek inferred chemical compound relationships for SHBG Gene

Compound -log(P) Hits PubMed IDs
testosterone 95.5 455
dehydroepiandrosterone sulfate 94.7 185
androstenedione 93.5 156
estradiol 91.9 271
estrone 87.4 117
genes like me logo Genes that share compounds with SHBG: view

Transcripts for SHBG Gene

Unigene Clusters for SHBG Gene

Sex hormone-binding globulin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SHBG Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1:
SP2: - -
SP3: -
SP4: - - -
SP5: -
SP6:

Relevant External Links for SHBG Gene

GeneLoc Exon Structure for
SHBG
ECgene alternative splicing isoforms for
SHBG

Expression for SHBG Gene

mRNA expression in normal human tissues for SHBG Gene

mRNA differential expression in normal tissues according to GTEx for SHBG Gene

This gene is overexpressed in Liver (26.3) and Testis (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SHBG Gene

SOURCE GeneReport for Unigene cluster for SHBG Gene Hs.632235

mRNA Expression by UniProt/SwissProt for SHBG Gene

P04278-SHBG_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are present in liver and testis
genes like me logo Genes that share expressions with SHBG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SHBG Gene

Orthologs for SHBG Gene

This gene was present in the common ancestor of chordates.

Orthologs for SHBG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SHBG 35
  • 99.42 (n)
  • 99.25 (a)
SHBG 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SHBG 35
  • 82.29 (n)
  • 75.06 (a)
SHBG 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SHBG 35
  • 81.51 (n)
  • 76.37 (a)
SHBG 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Shbg 35
  • 77.04 (n)
  • 67.28 (a)
Shbg 16
Shbg 36
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SHBG 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SHBG 36
  • 34 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Shbg 35
  • 77.4 (n)
  • 68.07 (a)
lizard
(Anolis carolinensis)
Reptilia SHBG 36
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498622 35
  • 46.77 (n)
  • 34.24 (a)
zebrafish
(Danio rerio)
Actinopterygii shbg 35
  • 43.96 (n)
  • 33.12 (a)
shbg 36
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 11 (a)
ManyToMany
-- 36
  • 5 (a)
ManyToMany
Species with no ortholog for SHBG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHBG Gene

ENSEMBL:
Gene Tree for SHBG (if available)
TreeFam:
Gene Tree for SHBG (if available)

Paralogs for SHBG Gene

Paralogs for SHBG Gene

genes like me logo Genes that share paralogs with SHBG: view

Variants for SHBG Gene

Sequence variations from dbSNP and Humsavar for SHBG Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs6257 -- 7,630,399(+) GTTTG(C/T)TTTCT intron-variant
rs6258 - 7,631,360(+) GTTGC(C/T)GGTAA reference, missense, intron-variant
rs6259 - 7,633,209(+) GAGAA(A/G)ACTCT missense, reference, synonymous-codon
rs6260 - 7,630,246(+) CACCC(A/G)CCAGG missense, reference, intron-variant, utr-variant-5-prime
rs6261 -- 7,632,766(+) TTGTC(C/T)TCTGG synonymous-codon, reference, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SHBG Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
nsv907651 CNV Loss 21882294
esv2715601 CNV Deletion 23290073
dgv531e199 CNV Deletion 23128226

Relevant External Links for SHBG Gene

HapMap Linkage Disequilibrium report
SHBG
Human Gene Mutation Database (HGMD)
SHBG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHBG Gene

Disorders for SHBG Gene

(94) Novoseek inferred disease relationships for SHBG Gene

Disease -log(P) Hits PubMed IDs
polycystic ovary syndrome 92.4 45
hyperandrogenism 90.8 35
androgen deficiency 82 7
insulin resistance 79.9 149
hypogonadism 79.9 11

Relevant External Links for SHBG

Genetic Association Database (GAD)
SHBG
Human Genome Epidemiology (HuGE) Navigator
SHBG
genes like me logo Genes that share disorders with SHBG: view

No data available for UniProtKB/Swiss-Prot for SHBG Gene

Publications for SHBG Gene

  1. Molecular analyses of a human sex hormone-binding globulin variant: evidence for an additional carbohydrate chain. (PMID: 1400872) Power S.G.A. … Hammond G.L. (J. Clin. Endocrinol. Metab. 1992) 3 4 23
  2. Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain. (PMID: 10675319) Grishkovskaya I. … Muller Y.A. (EMBO J. 2000) 3 4 23
  3. Steroid ligands bind human sex hormone-binding globulin in specific orientations and produce distinct changes in protein conformation. (PMID: 12065592) Grishkovskaya I. … Muller Y.A. (J. Biol. Chem. 2002) 3 4 23
  4. Influence of SHBG gene pentanucleotide TAAAA repeat and D327N polymorphism on serum sex hormone-binding globulin concentration in hirsute women. (PMID: 14764814) Cousin P. … Pugeat M. (J. Clin. Endocrinol. Metab. 2004) 3 23 48
  5. Association of the (TAAAA)n repeat polymorphism in the sex hormone-binding globulin (SHBG) gene with polycystic ovary syndrome and relation to SHBG serum levels. (PMID: 14671199) Xita N. … Georgiou I. (J. Clin. Endocrinol. Metab. 2003) 3 23 48

Products for SHBG Gene

Sources for SHBG Gene

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