Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SHB Gene

Aliases for SHB Gene

  • Src Homology 2 Domain Containing Adaptor Protein B 2 3
  • SHB (Src Homology 2 Domain Containing) Adaptor Protein B 2 3
  • SHB Adaptor Protein (A Src Homology 2 Protein) 2 3
  • SH2 Domain-Containing Adapter Protein B 3
  • BA3J10.2 3

External Ids for SHB Gene

Previous GeneCards Identifiers for SHB Gene

  • GC09M038231
  • GC09M038089
  • GC09M037909
  • GC09M037581
  • GC09M037925
  • GC09M037933
  • GC09M037953
  • GC09M037979

Summaries for SHB Gene

GeneCards Summary for SHB Gene

SHB (Src Homology 2 Domain Containing Adaptor Protein B) is a Protein Coding gene. Diseases associated with SHB include sulfhemoglobinemia and methemoglobinemia. Among its related pathways are PDGFR-beta signaling pathway and Development FGFR signaling pathway. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is SHF.

UniProtKB/Swiss-Prot for SHB Gene

  • Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.

Gene Wiki entry for SHB Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHB Gene

Genomics for SHB Gene

Regulatory Elements for SHB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SHB Gene

Start:
37,915,898 bp from pter
End:
38,069,213 bp from pter
Size:
153,316 bases
Orientation:
Minus strand

Genomic View for SHB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SHB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHB Gene

Proteins for SHB Gene

  • Protein details for SHB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15464-SHB_HUMAN
    Recommended name:
    SH2 domain-containing adapter protein B
    Protein Accession:
    Q15464
    Secondary Accessions:
    • B9EGM0
    • D3DRQ5
    • Q504U5
    • Q5VUM8

    Protein attributes for SHB Gene

    Size:
    509 amino acids
    Molecular mass:
    55042 Da
    Quaternary structure:
    • Interacts with PTPN11 (By similarity). Interacts with phosphorylated Tyr-720 of the ligand-activated receptor PDGFRA via its SH2 domain. Interacts with the ligand-activated receptors PDGFRB, FGFR1, KDR/VEGFR2, IL2RB and IL2RG. Interacts with EPS8 and V-SRC. Interacts with GRB2 and GRAP. Interacts with CD3Z. Interacts with tyrosine-phosphorylated LAT upon T-cell antigen receptor activation. Interacts with PLCG1. Interacts with ZAP70, LCP2/SLP-76, VAV1 and GRAP2. Interacts with JAK1 and JAK3. Interacts with PTK2/FAK1. Interacts with CRK/CrKII. Interacts with IRS2.
    SequenceCaution:
    • Sequence=AAH94765.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA53091.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SHB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SHB Gene

Proteomics data for SHB Gene at MOPED

Post-translational modifications for SHB Gene

  • Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SHB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHB Gene

Domains for SHB Gene

Gene Families for SHB Gene

HGNC:
  • SH2D :SH2 domain containing

Protein Domains for SHB Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SHB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15464

UniProtKB/Swiss-Prot:

SHB_HUMAN :
  • Q15464
Domain:
  • The SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SHB: view

Function for SHB Gene

Molecular function for SHB Gene

GENATLAS Biochemistry: adaptor protein,ubiquitously expressed with SH2 domain (?signal transduction)
UniProtKB/Swiss-Prot Function: Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.

Gene Ontology (GO) - Molecular Function for SHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 8302579
GO:0005515 protein binding IPI 17112510
genes like me logo Genes that share ontologies with SHB: view
genes like me logo Genes that share phenotypes with SHB: view

Animal Models for SHB Gene

MGI Knock Outs for SHB:
  • Shb tm1.1Miwe

Animal Model Products

CRISPR Products

miRNA for SHB Gene

miRTarBase miRNAs that target SHB

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SHB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SHB Gene

Localization for SHB Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHB Gene

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membrane lipid rafts upon TCR stimulation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SHB Gene COMPARTMENTS Subcellular localization image for SHB gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with SHB: view

Pathways for SHB Gene

genes like me logo Genes that share pathways with SHB: view

Pathways by source for SHB Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction TAS 8302579
GO:0009967 positive regulation of signal transduction TAS 8302579
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SHB: view

Compounds for SHB Gene

(6) Novoseek inferred chemical compound relationships for SHB Gene

Compound -log(P) Hits PubMed IDs
tyrosine 52.4 8
phosphotyrosine 47.3 1
phenylalanine 33.8 1
phosphatidylinositol 27.5 2
vegf 20.4 6
genes like me logo Genes that share compounds with SHB: view

Transcripts for SHB Gene

mRNA/cDNA for SHB Gene

(20) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SHB Gene

Src homology 2 domain containing adaptor protein B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SHB

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SHB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHB Gene

No ASD Table

Relevant External Links for SHB Gene

GeneLoc Exon Structure for
SHB
ECgene alternative splicing isoforms for
SHB

Expression for SHB Gene

mRNA expression in normal human tissues for SHB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SHB Gene

SOURCE GeneReport for Unigene cluster for SHB Gene Hs.521482

mRNA Expression by UniProt/SwissProt for SHB Gene

Q15464-SHB_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with SHB: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SHB Gene

Orthologs for SHB Gene

This gene was present in the common ancestor of animals.

Orthologs for SHB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SHB 35
  • 99.02 (n)
  • 99.41 (a)
SHB 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SHB 35
  • 91.91 (n)
  • 97.24 (a)
SHB 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SHB 35
  • 92.45 (n)
  • 96.65 (a)
SHB 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Shb 35
  • 85.5 (n)
  • 89.62 (a)
Shb 16
Shb 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SHB 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SHB 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Shb 35
  • 85.96 (n)
  • 90.02 (a)
chicken
(Gallus gallus)
Aves SHB 35
  • 73.61 (n)
  • 76.5 (a)
SHB 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SHB 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489262 35
  • 67.99 (n)
  • 69.31 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43921 36
  • 8 (a)
OneToMany
Species with no ortholog for SHB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SHB Gene

ENSEMBL:
Gene Tree for SHB (if available)
TreeFam:
Gene Tree for SHB (if available)

Paralogs for SHB Gene

Paralogs for SHB Gene

Selected SIMAP similar genes for SHB Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SHB: view

Variants for SHB Gene

Sequence variations from dbSNP and Humsavar for SHB Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs706148 -- 37,918,112(-) TTGAA(C/T)GTCAT utr-variant-3-prime
rs735740 -- 37,944,430(+) CATGA(A/G)GCAAA intron-variant
rs735741 -- 37,944,492(+) CTTTC(A/G/T)ACTGA intron-variant
rs749632 -- 37,937,946(-) TCAGA(G/T)CCCAA intron-variant
rs751449 -- 37,937,282(+) TAAAA(C/T)GTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SHB Gene

Variant ID Type Subtype PubMed ID
nsv469814 CNV Gain 16826518
dgv8169n71 CNV Loss 21882294
esv2738434 CNV Deletion 23290073
esv2738435 CNV Deletion 23290073
dgv485n21 CNV Loss 19592680
nsv428210 CNV Loss 18775914
esv2664571 CNV Deletion 23128226
esv22578 CNV Loss 19812545

Relevant External Links for SHB Gene

HapMap Linkage Disequilibrium report
SHB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHB Gene

Disorders for SHB Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for SHB Gene including...

Search for SHB Gene in MalaCards »

(2) University of Copenhagen DISEASES for SHB Gene

Relevant External Links for SHB

Genetic Association Database (GAD)
SHB
Human Genome Epidemiology (HuGE) Navigator
SHB
genes like me logo Genes that share disorders with SHB: view

No data available for UniProtKB/Swiss-Prot for SHB Gene

Publications for SHB Gene

  1. Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins. (PMID: 7537362) Karlsson T. … Welsh M. (Oncogene 1995) 3 4 23
  2. The SHB adaptor protein maps to human chromosome 9. (PMID: 7713524) Yulug I.G. … Fisher E.M. (Genomics 1994) 2 3 23
  3. Apoptosis of NIH3T3 cells overexpressing the Src homology 2 domain protein Shb. (PMID: 8806685) Karlsson T. … Welsh M. (Oncogene 1996) 3 4 23
  4. Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins. (PMID: 9484780) Welsh M. … Shoelson S.E. (Oncogene 1998) 3 4 23
  5. The Src homology 2 domain protein Shb transmits basic fibroblast growth factor- and nerve growth factor-dependent differentiation signals in PC12 cells. (PMID: 9751119) Karlsson T. … Welsh M. (Cell Growth Differ. 1998) 3 4 23

Products for SHB Gene

Sources for SHB Gene

Back to Top

Content