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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SHB Gene

protein-coding   GIFtS: 61
GCID: GC09M037933

Src homology 2 domain containing adaptor protein B

(Previous names: SHB adaptor protein (a Src homology 2 protein), SHB (Src...)
 Explore 5 diseases affiliated with
SHB via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SHB    

Aliases
for SHB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Src Homology 2 Domain Containing Adaptor Protein B1 2
SHB (Src Homology 2 Domain Containing) Adaptor Protein B1 2
SHB Adaptor Protein (A Src Homology 2 Protein)1 2
RP11-3J10.82
BA3J10.21
SH2 Domain-Containing Adapter Protein B2

External Ids:    HGNC: 108381   Entrez Gene: 64612   Ensembl: ENSG000001073387   OMIM: 6003145   UniProtKB: Q154643   

Export aliases for SHB gene to outside databases

Previous GC identifers: GC09M038231 GC09M038089 GC09M037909 GC09M037581 GC09M037925


Summaries
for SHB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SHB_HUMAN, Q15464
Function: Adapter protein which regulates several signal transduction cascades by linking activated receptors to
downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May
also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells
differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling
in insulin-producing cells

Gene Wiki entry for SHB


Genomic Views
for SHB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SHB gene promoter:
         Oct-B1   c-Fos   USF1   AP-1   USF-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SHB promoter sequence
   Search SABiosciences Chromatin IP Primers for SHB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.2   Ensembl cytogenetic band:  9p13.2   HGNC chromosome: 9

SHB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHB gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M037933:  view genomic region     (about GC identifiers)

Start:
 37,915,895 bp from pter      End:
 38,069,210 bp from pter
Size:
 153,316 bases      Orientation:
 minus strand

Proteins
for SHB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SHB_HUMAN, Q15464 (See protein sequence)
Recommended Name: SH2 domain-containing adapter protein B  
Size: 509 amino acids; 55042 Da
Subunit: Interacts with PTPN11 (By similarity). Interacts with phosphorylated 'Tyr-720' of the ligand-activated
receptor PDGFRA via its SH2 domain. Interacts with the ligand-activated receptors PDGFRB, FGFR1, KDR/VEGFR2, IL2RB and
IL2RG. Interacts with EPS8 and V-SRC. Interacts with GRB2 and GRAP. Interacts with CD3Z. Interacts with
tyrosine-phosphorylated LAT upon T-cell antigen receptor activation. Interacts with PLCG1. Interacts with ZAP70,
LCP2/SLP-76, VAV1 and GRAP2. Interacts with JAK1 and JAK3. Interacts with PTK2/FAK1. Interacts with CRK/CrKII.
Interacts with IRS2
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with
membrane lipid rafts upon TCR stimulation
Sequence caution: Sequence=AAH94765.1; Type=Erroneous initiation; Sequence=CAA53091.1; Type=Erroneous initiation;
Secondary accessions: B9EGM0 D3DRQ5 Q504U5 Q5VUM8
Alternative splicing: 2 isoforms:  Q15464-1   Q15464-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SHB: NX_Q15464

Post-translational modifications:

  • Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15464

    • SHB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003019.2  
    ENSEMBL proteins: 
     ENSP00000366936   ENSP00000366929  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: SHB
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    Novus Biologicals SHB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SHB

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--


    SHB for ontologies           About GeneDecksing



    SHB Antibody Products: 
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    Abcam antibodies for SHB 
    Uscn Antibodies for SHB
    ThermoFisher Antibodies for SHB

    Assay Products for SHB: 
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    Uscn ELISAs and CLIAs for SHB

    Protein Domains /
    Families
    for SHB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SHB for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q15464

    ProtoNet protein and cluster: Q15464

    1 Blocks protein family: IPB000980 SH2 domain signature

    UniProtKB/Swiss-Prot: SHB_HUMAN, Q15464
    Domain: The SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates
    interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII
    Similarity: Contains 1 SH2 domain


    Function
    for SHB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SHB_HUMAN, Q15464
    Function: Adapter protein which regulates several signal transduction cascades by linking activated receptors to
    downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May
    also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells
    differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling
    in insulin-producing cells

         Genatlas biochemistry entry for SHB:
    adaptor protein,ubiquitously expressed with SH2 domain (?signal transduction)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SHB
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SHB
    8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate SHB (see all 75):
    hsa-miR-576-3p hsa-miR-4267 hsa-miR-3916 hsa-miR-149 hsa-miR-3148 hsa-miR-490-3p hsa-miR-877 hsa-miR-4300
    SwitchGear 3'UTR luciferase reporter plasmid: SHB 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    Browse OriGene 29mer shRNA kits
    OriGene siRNA: SHB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SHB

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SHB

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SHB (see all 2)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SHB (NM_001018080)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SHB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHB 

    Cell Line
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    Search LifeMap BioReagents cell lines for SHB

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHB

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001948glycoprotein binding ----
    GO:0005070SH3/SH2 adaptor activity TAS8302579


    SHB for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SHB:
     Increased G1 DNA content 

    Animal Models:
         Mouse knock-out Shbtm1.1Miwe for SHB
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Shb):
     cardiovascular system  embryogenesis  limbs/digits/tail  mortality/aging  nervous system 
     no phenotypic analysis  reproductive system 

    SHB for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SHB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development FGFR signaling pathway
    		Development FGFR signaling pathway1.00
    		Development_FGFR signaling pathway0.98
    2IL-2 Signaling Pathway
    		IL-2 Signaling Pathway1.00
    3PDGFR-beta signaling pathway
    		PDGFR-beta signaling pathway1.00
    4PDGFR-alpha signaling pathway
    		PDGFR-alpha signaling pathway1.00
    5Signaling events mediated by VEGFR1 and VEGFR2
    		Signaling events mediated by VEGFR1 and VEGFR21.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for SHB
        Development FGFR signaling pathway


    2 GeneGo (Thomson Reuters) Pathways for SHB
        Development VEGF signaling via VEGFR2 - generic cascades
    Development FGFR signaling pathway

    4 BioSystems Pathways for SHB 
        IL-2 Signaling Pathway
    PDGFR-beta signaling pathway
    Signaling events mediated by VEGFR1 and VEGFR2
    PDGFR-alpha signaling pathway



    SHB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SHB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/119 Interacting proteins for SHB (Q154642, 3 ENSP000003669364) via UniProtKB, MINT, STRING, and/or I2D (see all 119)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005192, 3, ENSP000003614234MINT-7046591 MINT-7046551 MINT-7046613 MINT-7046561 MINT-7046541 I2D: score=1 STRING: ENSP00000361423
    IL2RBP147842, 3, ENSP000002162234MINT-8035186 I2D: score=3 STRING: ENSP00000216223
    KDRP359682, 3, ENSP000002639234MINT-8036377 I2D: score=3 STRING: ENSP00000263923
    FGFR1P113622, 3, ENSP000003802804MINT-8037812 I2D: score=3 STRING: ENSP00000380280
    PIK3R1P279863, ENSP000002743354I2D: score=3 STRING: ENSP00000274335
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction TAS8302579
    GO:0030154cell differentiation IEA--
    GO:0042100B cell proliferation ----


    SHB for ontologies           About GeneDecksing



    Drugs & Compounds
    for SHB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SHB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SHB
    6 Novoseek chemical compound relationships for SHB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 52.4 14 9751119 (2), 8806685 (2), 15026417 (1), 8777141 (1) (see all 6)
    phosphotyrosine 47.3 2 9484780 (1)
    phenylalanine 33.8 2 12200137 (1)
    phosphatidylinositol 27.5 2 15026417 (2)
    vegf 20.4 8 15026417 (5), 16835467 (1)
    calcium 0 1 10488157 (1)

    Search CenterWatch for drugs/clinical trials and news about SHB 

    Transcripts
    for SHB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SHB gene: 
    NM_003028.2  

    Unigene Cluster for SHB:

    Src homology 2 domain containing adaptor protein B
    Hs.521482  [show with all ESTs]
    Unigene Representative Sequence: NM_003028
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377707(uc004aax.3) ENST00000377700

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SHB
    8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate SHB (see all 75):
    hsa-miR-576-3p hsa-miR-4267 hsa-miR-3916 hsa-miR-149 hsa-miR-3148 hsa-miR-490-3p hsa-miR-877 hsa-miR-4300
    SwitchGear 3'UTR luciferase reporter plasmid: SHB 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    Browse OriGene 29mer shRNA kits
    OriGene siRNA: SHB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SHB
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SHB (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SHB
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SHB (NM_001018080)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SHB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHB 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SHB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SHB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SHB

    Additional cDNA sequence: 

    AK055947.1 AK096227.1 BC029953.1 BC136581.1 BC136582.1 X75342.1 

    9 DOTS entries:

    DT.75193214  DT.121192501  DT.121192683  DT.100755541  DT.97784668  DT.100655154  DT.100746304  DT.100755540 
    DT.121192533 

    20 AceView cDNA sequences:

    AW295062 BM893981 BQ958415 BC029953 BI962546 BV184490 CK821172 AW302147 
    BG326702 BM967333 BE778005 BE562483 BV207870 AI521954 BI789094 BQ439455 
    AI446569 BE042569 CD580276 BM545205 

    GeneLoc Exon Structure


    Expression
    for SHB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SHB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SHB expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    Definitive endoderm-like cells (A scalable, suspensi...)

    See SHB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SHB

    SOURCE GeneReport for Unigene cluster: Hs.521482

    UniProtKB/Swiss-Prot: SHB_HUMAN, Q15464
    Tissue specificity: Widely expressed

        SABiosciences Expression via Pathway-Focused PCR Array including SHB: 
              Type I Interferon Response in human mouse rat

    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SHB
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHB

    Orthologs
    for SHB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SHB gene from 3/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SHB1 Src homology 2 domain containing adaptor protein B 74.13(n)
    77.16(a)    		   427280  XM_424863.3  XP_424863.3 
    lizard
    (Anolis carolinensis)    		 Reptilia SHB6
    		 --
    		 85(a)
    		 1 ↔ 1
    		 GL343666.1(79690-101331)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG439216
    		 --
    		 6(a)
    		 1 → many
    		 X(12410667-12462394)


    ENSEMBL Gene Tree for SHB (if available)
    TreeFam Gene Tree for SHB (if available) 

    Paralogs
    for SHB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SHB gene
    SHE2  SHF2  ENSG000002558722  SHD2  
    2 SIMAP similar genes for SHB using alignment to 1 protein entry:     SHB_HUMAN:
    SHF    SHE

    SHB for paralogs           About GeneDecksing



    Genomic Variants
    for SHB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2706 NCBI SNPs in SHB are shown (see all 2706)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2008534451,2
    		C--37872669(+) AAAAAA/CAAAAC 1 -- int10--------
    rs727241831,2
    		C,F,--37915442(+) AATCCA/GCCTTT 1 -- ds50011Minor allele frequency- G:0.03NA 120
    rs1925003271,2
    		--37915454(+) GAAGCC/TGATGG 1 -- ds50010--------
    rs7760271,2
    		C,H,--37915601(+) CCGCCT/AGTAAT 1 -- ds500114Minor allele frequency- A:0.00NS EA NA WA CSA 790
    rs1465494861,2
    		--37915649(+) AAGCCC/TAGGAG 1 -- ds50010--------
    rs1411693601,2
    		--37915697(+) CTCTAC/TTAAAA 1 -- ds50010--------
    rs1851097741,2
    		--37915809(+) TGAGTG/TGAGAC 1 -- ds50010--------
    rs613628391,2
    		C,--37915867(+) AAAAAA/GAAAGA 1 -- ds50012Minor allele frequency- G:0.09WA 120
    rs1879163261,2
    		--37916048(+) GGGAGA/GTGGAA 1 -- ut310--------
    rs773907011,2
    		F,--37916107(+) AAGCGC/TGCCTG 1 -- ut312Minor allele frequency- T:0.05WA EA 238

    HapMap Linkage Disequilibrium report for SHB (37915895 - 38069210 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for SHB
         3 CNVs: 70549 2127 65386

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    Disorders / Diseases
    for SHB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SHB for disorders           About GeneDecksing

    OMIM gene information: 600314    OMIM disorders: --

    5 diseases for SHB:    About MalaCards
    sulfhemoglobinemia    methemoglobinemia    prostate cancer    prostatitis
    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for SHB:
    Sulfhemoglobinemia     Methemoglobinemia
    Human Genome Epidemiology (HuGE) Navigator: SHB (3 documents)

    Export disorders for SHB gene to outside databases

    Publications
    for SHB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SHB gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with SHB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF- dependent cellular migration. (PubMed id 15026417)1, 2, 9 Holmqvist K.... Welsh M. (2004)
    2. The Src homology 2 domain protein Shb transmits basic fibroblast growth factor- and nerve growth factor-dependent differentiation signals in PC12 cells. (PubMed id 9751119)1, 2, 9 Karlsson T.... Welsh M. (1998)
    3. Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins. (PubMed id 9484780)1, 2, 9 Welsh M.... Shoelson S.E. (1998)
    4. IL-2 receptor signaling through the Shb adapter protein in T and NK cells. (PubMed id 12200137)1, 2, 9 Lindholm C.K. (2002)
    5. Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells. (PubMed id 10488157)1, 2, 9 Lindholm C.K.... Welsh M. (1999)
    6. Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins. (PubMed id 7537362)1, 2, 9 Karlsson T.... Welsh M. (1995)
    7. The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells. (PubMed id 12181353)1, 2, 9 Cross M.J....Claesson-Welsh L. (2002)
    8. NGF-dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway. (PubMed id 10964504)1, 2, 9 Lu L.... Welsh M. (2000)
    9. Apoptosis of NIH3T3 cells overexpressing the Src homology 2 domain protein Shb. (PubMed id 8806685)1, 2, 9 Karlsson T. and Welsh M. (1996)
    10. The SHB adaptor protein maps to human chromosome 9. (PubMed id 7713524)1, 3, 9 Yulug I.G....Fisher E.M. (1994)

    External Searches for SHB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing SHB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6461 HGNC: 10838 AceView: SHB.1 Ensembl:ENSG00000107338 euGenes: HUgn6461
    ECgene: SHB H-InvDB: SHB

    Other Databases showing SHB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SHB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SHB Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SHB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SHB gene:
    Search GeneIP for patents involving SHB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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