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Aliases for SHB Gene

Aliases for SHB Gene

  • SH2 Domain Containing Adaptor Protein B 2 3
  • Src Homology 2 Domain Containing Adaptor Protein B 2 3 5
  • SHB (Src Homology 2 Domain Containing) Adaptor Protein B 2 3
  • SHB Adaptor Protein (A Src Homology 2 Protein) 2 3
  • BA3J10.2 3

External Ids for SHB Gene

Previous GeneCards Identifiers for SHB Gene

  • GC09M038231
  • GC09M038089
  • GC09M037909
  • GC09M037581
  • GC09M037925
  • GC09M037933
  • GC09M037953
  • GC09M037979
  • GC09M037972
  • GC09M038001

Summaries for SHB Gene

GeneCards Summary for SHB Gene

SHB (SH2 Domain Containing Adaptor Protein B) is a Protein Coding gene. Diseases associated with SHB include sulfhemoglobinemia. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is SHF.

UniProtKB/Swiss-Prot for SHB Gene

  • Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.

Gene Wiki entry for SHB Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHB Gene

Genomics for SHB Gene

Regulatory Elements for SHB Gene

Promoters for SHB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SHB on UCSC Golden Path with GeneCards custom track

Genomic Location for SHB Gene

Chromosome:
9
Start:
37,915,898 bp from pter
End:
38,069,213 bp from pter
Size:
153,316 bases
Orientation:
Minus strand

Genomic View for SHB Gene

Genes around SHB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHB Gene

Proteins for SHB Gene

  • Protein details for SHB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15464-SHB_HUMAN
    Recommended name:
    SH2 domain-containing adapter protein B
    Protein Accession:
    Q15464
    Secondary Accessions:
    • B9EGM0
    • D3DRQ5
    • Q504U5
    • Q5VUM8

    Protein attributes for SHB Gene

    Size:
    509 amino acids
    Molecular mass:
    55042 Da
    Quaternary structure:
    • Interacts with PTPN11 (By similarity). Interacts with phosphorylated Tyr-720 of the ligand-activated receptor PDGFRA via its SH2 domain. Interacts with the ligand-activated receptors PDGFRB, FGFR1, KDR/VEGFR2, IL2RB and IL2RG. Interacts with EPS8 and V-SRC. Interacts with GRB2 and GRAP. Interacts with CD3Z. Interacts with tyrosine-phosphorylated LAT upon T-cell antigen receptor activation. Interacts with PLCG1. Interacts with ZAP70, LCP2/SLP-76, VAV1 and GRAP2. Interacts with JAK1 and JAK3. Interacts with PTK2/FAK1. Interacts with CRK/CrKII. Interacts with IRS2.
    SequenceCaution:
    • Sequence=AAH94765.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA53091.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SHB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SHB Gene

Proteomics data for SHB Gene at MOPED

Post-translational modifications for SHB Gene

  • Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SHB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SHB Gene

Domains & Families for SHB Gene

Gene Families for SHB Gene

Protein Domains for SHB Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SHB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15464

UniProtKB/Swiss-Prot:

SHB_HUMAN :
  • The SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII.
Domain:
  • The SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SHB: view

Function for SHB Gene

Molecular function for SHB Gene

GENATLAS Biochemistry:
adaptor protein,ubiquitously expressed with SH2 domain (?signal transduction)
UniProtKB/Swiss-Prot Function:
Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
genes like me logo Genes that share phenotypes with SHB: view

Animal Models for SHB Gene

MGI Knock Outs for SHB:
  • Shb tm1.1Miwe

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SHB Gene

Localization for SHB Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHB Gene

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membrane lipid rafts upon TCR stimulation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SHB Gene COMPARTMENTS Subcellular localization image for SHB gene
Compartment Confidence
cytosol 5
plasma membrane 5
nucleus 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for SHB Gene

Pathways & Interactions for SHB Gene

genes like me logo Genes that share pathways with SHB: view

Gene Ontology (GO) - Biological Process for SHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8302579
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SHB: view

No data available for SIGNOR curated interactions for SHB Gene

Drugs & Compounds for SHB Gene

(3) Drugs for SHB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for SHB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SHB: view

Transcripts for SHB Gene

mRNA/cDNA for SHB Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SHB Gene

Src homology 2 domain containing adaptor protein B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SHB Gene

No ASD Table

Relevant External Links for SHB Gene

GeneLoc Exon Structure for
SHB
ECgene alternative splicing isoforms for
SHB

Expression for SHB Gene

mRNA expression in normal human tissues for SHB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SHB Gene

This gene is overexpressed in Esophagus (39.5) and Pancreatic juice (25.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SHB Gene



SOURCE GeneReport for Unigene cluster for SHB Gene Hs.521482

mRNA Expression by UniProt/SwissProt for SHB Gene

Q15464-SHB_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with SHB: view

Protein tissue co-expression partners for SHB Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SHB Gene

Orthologs for SHB Gene

This gene was present in the common ancestor of animals.

Orthologs for SHB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SHB 35
  • 91.91 (n)
  • 97.24 (a)
SHB 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SHB 35
  • 92.45 (n)
  • 96.65 (a)
SHB 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Shb 35
  • 85.5 (n)
  • 89.62 (a)
Shb 16
Shb 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SHB 35
  • 99.02 (n)
  • 99.41 (a)
SHB 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Shb 35
  • 85.96 (n)
  • 90.02 (a)
oppossum
(Monodelphis domestica)
Mammalia SHB 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SHB 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves SHB 35
  • 73.61 (n)
  • 76.5 (a)
SHB 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SHB 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489262 35
  • 67.99 (n)
  • 69.31 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43921 36
  • 8 (a)
OneToMany
Species with no ortholog for SHB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SHB Gene

ENSEMBL:
Gene Tree for SHB (if available)
TreeFam:
Gene Tree for SHB (if available)

Paralogs for SHB Gene

Paralogs for SHB Gene

(2) SIMAP similar genes for SHB Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SHB: view

Variants for SHB Gene

Sequence variations from dbSNP and Humsavar for SHB Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs706148 -- 37,918,112(-) TTGAA(C/T)GTCAT utr-variant-3-prime
rs870410 -- 37,978,586(-) CCTGC(A/G)TTATA intron-variant
rs1105773 -- 37,979,223(+) TATTA(A/G)GTGGC intron-variant
rs1105774 -- 37,979,381(+) ATGTT(A/T)GAACT intron-variant
rs749632 -- 37,937,946(-) TCAGA(G/T)CCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SHB Gene

Variant ID Type Subtype PubMed ID
nsv469814 CNV Gain 16826518
dgv8169n71 CNV Loss 21882294
esv2738434 CNV Deletion 23290073
esv2738435 CNV Deletion 23290073
dgv485n21 CNV Loss 19592680
nsv428210 CNV Loss 18775914
esv2664571 CNV Deletion 23128226
esv22578 CNV Loss 19812545

Variation tolerance for SHB Gene

Gene Damage Index Score: 3.28; 53.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SHB Gene

HapMap Linkage Disequilibrium report
SHB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHB Gene

Disorders for SHB Gene

MalaCards: The human disease database

(1) MalaCards diseases for SHB Gene - From: DISEASES

Disorder Aliases PubMed IDs
sulfhemoglobinemia
  • sulfemoglobinemia
- elite association - COSMIC cancer census association via MalaCards
Search SHB in MalaCards View complete list of genes associated with diseases

Relevant External Links for SHB

Genetic Association Database (GAD)
SHB
Human Genome Epidemiology (HuGE) Navigator
SHB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SHB
genes like me logo Genes that share disorders with SHB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SHB Gene

Publications for SHB Gene

  1. The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF- dependent cellular migration. (PMID: 15026417) Holmqvist K. … Welsh M. (J. Biol. Chem. 2004) 3 4 23 67
  2. The SHB adaptor protein maps to human chromosome 9. (PMID: 7713524) Yulug I.G. … Fisher E.M. (Genomics 1994) 2 3 23
  3. Consequences of Shb and c-Abl interactions for cell death in response to various stress stimuli. (PMID: 17112510) HAogerkvist R. … Welsh M. (Exp. Cell Res. 2007) 3 23
  4. The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells. (PMID: 12181353) Cross M.J. … Claesson-Welsh L. (Mol. Biol. Cell 2002) 3 23
  5. IL-2 receptor signaling through the Shb adapter protein in T and NK cells. (PMID: 12200137) Lindholm C.K. (Biochem. Biophys. Res. Commun. 2002) 3 23

Products for SHB Gene

Sources for SHB Gene

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