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SHANK1 Gene

protein-coding   GIFtS: 59
GCID: GC19M051165

SH3 And Multiple Ankyrin Repeat Domains 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SH3 And Multiple Ankyrin Repeat Domains 11 2     SPANK-12
Somatostatin Receptor-Interacting Protein1 2 3     SH3 And Multiple Ankyrin Repeat Domains Protein 12
SSTRIP2 3 5     synamon2
SSTR-Interacting Protein2 3     Shank13

External Ids:    HGNC: 154741   Entrez Gene: 509442   Ensembl: ENSG000001616817   OMIM: 6049995   UniProtKB: Q9Y5663   

Export aliases for SHANK1 gene to outside databases

Previous GC identifers: GC19M051793 GC19M051526 GC19M055841 GC19M055856 GC19M055818 GC19M047499


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SHANK1 Gene:
SHANK1 (SH3 and multiple ankyrin repeat domains 1) is a protein-coding gene. GO annotations related to this gene include SH3 domain binding and identical protein binding. An important paralog of this gene is SHANK3.

UniProtKB/Swiss-Prot: SHAN1_HUMAN, Q9Y566
Function: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that
interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via
complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the
structural and functional organization of the dendritic spine and synaptic junction

Gene Wiki entry for SHANK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SHANK1 gene promoter:
         Max1   Pax-5   Tal-1   AP-1   NRSF form 1   STAT5A   NRSF form 2   E47   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SHANK1 promoter sequence
   Search Chromatin IP Primers for SHANK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SHANK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

SHANK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHANK1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051165:  view genomic region     (about GC identifiers)

Start:
51,165,084 bp from pter      End:
51,222,707 bp from pter
Size:
57,624 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SHAN1_HUMAN, Q9Y566 (See protein sequence)
Recommended Name: SH3 and multiple ankyrin repeat domains protein 1  
Size: 2161 amino acids; 224959 Da
Subunit: May homomultimerize via its SAM domain (By similarity). Interacts with the C-terminus of SSTR2 via the
PDZ domain. Interacts with IGSF9, SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP isoforms 1 and 2 (By similarity). Part
of a complex with DLG4/PSD-95 and DLGAP1/GKAP (By similarity). Interacts with BAIAP2
Secondary accessions: A8MXP5 B7WNY6 Q9NYW9
Alternative splicing: 3 isoforms:  Q9Y566-1   Q9Y566-2   Q9Y566-3   

Explore the universe of human proteins at neXtProt for SHANK1: NX_Q9Y566

Explore proteomics data for SHANK1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SHANK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057232.2  
    ENSEMBL proteins: 
     ENSP00000375689   ENSP00000293441   ENSP00000375690   ENSP00000351984   ENSP00000469719  

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    antibodies-online antibodies for SHANK1 (58 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing
    SAMD: Sterile alpha motif (SAM) domain containing

    Selected InterPro protein domains (see all 8):
     IPR021129 SAM_type1
     IPR001452 SH3_domain
     IPR002110 Ankyrin_rpt
     IPR011511 SH3_2
     IPR013761 SAM/pointed

    Graphical View of Domain Structure for InterPro Entry Q9Y566

    ProtoNet protein and cluster: Q9Y566

    5 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB001478 PDZ/DHR/GLGF domain
    IPB001660 Sterile alpha motif SAM
    IPB002110 Ankyrin repeat signature
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: SHAN1_HUMAN, Q9Y566
    Similarity: Belongs to the SHANK family
    Similarity: Contains 6 ANK repeats
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with SHANK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SHAN1_HUMAN, Q9Y566
    Function: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that
    interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via
    complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the
    structural and functional organization of the dendritic spine and synaptic junction

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10551867
    GO:0008022protein C-terminus binding ISS--
    GO:0017124SH3 domain binding ISS--
    GO:0030159receptor signaling complex scaffold activity ----
    GO:0030160GKAP/Homer scaffold activity ISS--
         
    Find genes that share ontologies with SHANK1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SHANK1:
     Decreased homologous recombina 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Shank1):
     behavior/neurological  nervous system  reproductive system 

    Find genes that share phenotypes with SHANK1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Shank1tm1Shng for SHANK1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SHANK1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SHANK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SHANK1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SHANK1

    miRNA
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    miRTarBase miRNAs that target SHANK1:
    hsa-mir-335-5p (MIRT019080), hsa-let-7e-5p (MIRT051440)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SHAN1_HUMAN, Q9Y566: Cytoplasm (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic
    density (By similarity). Cell junction, synapse (By similarity). Note=Colocalizes with alpha-latrotoxin receptor
    1 (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol3
    nucleus3
    plasma membrane3

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular NAS10551867
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane ISS--
    GO:0008328colocalizes with ionotropic glutamate receptor complex ISS--
    GO:0016020membrane IDA10551867

    Find genes that share ontologies with SHANK1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SHANK1 About    
    See pathways by source

    SuperPathContained pathways About
    1Circadian entrainment
    Glutamatergic synapse0.39
    2Cytoplasmic microtubules
    Cytoplasmic microtubules0.32


    Find genes that share SuperPaths with SHANK1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for SHANK1):
        Glutamatergic synapse

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SHANK1
    Interactions:

        GeneGlobe Interaction Network for SHANK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SHANK1 (Q9Y5662, 3 ENSP000002934414) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LPHN2O954902, 3, ENSP000003222704MINT-72956 I2D: score=3 STRING: ENSP00000322270
    DLGAP1O144902, 3, ENSP000003163774MINT-7894188 I2D: score=6 STRING: ENSP00000316377
    BAI2O602412, 3, ENSP000003627624MINT-72957 I2D: score=3 STRING: ENSP00000362762
    ARHGEF7Q141553, ENSP000003648934I2D: score=3 STRING: ENSP00000364893
    LPHN1O949103, ENSP000003406884I2D: score=3 STRING: ENSP00000340688
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly ISS--
    GO:0007016cytoskeletal anchoring at plasma membrane NAS10551867
    GO:0007616long-term memory ISS--
    GO:0008306associative learning ISS--
    GO:0030534adult behavior IMP--

    Find genes that share ontologies with SHANK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SHANK1 (SHAN1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SHANK1 gene: 
    NM_016148.2  

    Unigene Cluster for SHANK1:

    SH3 and multiple ankyrin repeat domains 1
    Hs.274255  [show with all ESTs]
    Unigene Representative Sequence: AF163302
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391813(uc002psw.1) ENST00000293441(uc002psx.1) ENST00000391814(uc010yce.1)
    ENST00000359082 ENST00000483981 ENST00000468654 ENST00000461154 ENST00000483128

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    hsa-miR-4257
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    Additional mRNA sequence: 

    AF163302.1 AF226728.1 

    4 DOTS entries:

    DT.92419193  DT.121486651  DT.92419190  DT.91699571 

    24 AceView cDNA sequences:

    AI554563 BF969037 AY461451 BM475356 BV196293 BX283115 BF771112 NM_016148 
    BF770520 CK299116 AF226728 BI196108 BF970858 AF163302 BQ422598 R88191 
    BE258286 BG251239 AW857250 AW900154 BF952105 CK000629 BI195188 BE066122 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SHANK1 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                                                                                                            
    SP2:                                                                                                            
    SP3:                                                  -                                                         
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for SHANK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SHANK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACATCGACC
    SHANK1 Expression
    About this image

    SHANK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SHANK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.274255

    UniProtKB/Swiss-Prot: SHAN1_HUMAN, Q9Y566
    Tissue specificity: Expressed in brain particularly in the amygdala, hippocampus, substantia nigra and thalamus.
    Isoform 2 seems to be expressed ubiquitously

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SHANK1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Shank11 , 5 SH3/ankyrin domain gene 11, 5 85.93(n)1
    94.01(a)1
      7 (28.83 cM)5
    2439611  NM_001034115.11  NP_001029287.11 
     443102535 
    lizard
    (Anolis carolinensis)
    Reptilia SHANK16
    SH3 and multiple ankyrin repeat domains 1
    67(a)
    1 ↔ 1
    6(79302998-79427671)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia shank11 SH3 and multiple ankyrin repeat domains 1 61.64(n)
    65.94(a)
      100486091  XM_002938536.2  XP_002938582.2 
    zebrafish
    (Danio rerio)
    Actinopterygii SHANK1 (2 of 2)6
    SHANK1 (1 of 2)6
    SH3 and multiple ankyrin repeat domains 1
    65(a)
    50(a)
    many → 1
    many → 1
    24(39906443-39967952) ENSDARG00000086129
    3(30851394-31012296) ENSDARG00000060539
    fruit fly
    (Drosophila melanogaster)
    Insecta Prosap6
    Prosap
    23(a)
    1 → many
    2R(9947961-10028403)
    worm
    (Caenorhabditis elegans)
    Secernentea C33B4.33 ankyrin and proline rich domains 44(a)   II(11384828-11390687)   --


    ENSEMBL Gene Tree for SHANK1 (if available)
    TreeFam Gene Tree for SHANK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SHANK1 gene
    SHANK32  SHANK22  
    3 SIMAP similar genes for SHANK1 using alignment to 3 protein entries:     SHAN1_HUMAN (see all proteins):
    ARHGEF7    SHANK2    ARHGAP23

    Find genes that share paralogs with SHANK1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SHANK1 (see all 1127)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365414
    A colorectal cancer sample4--see VAR_0365412 A D mis40--------
    VAR_0365424
    A colorectal cancer sample4--see VAR_0365422 G R mis40--------
    rs341541081,2
    C--51164997(+) CGCTT-/CACACAC 1 -- ds50013Minor allele frequency- CA:0.00CSA 8
    rs38332361,2
    C--51165008(+) CACAC-/ACACACT 1 -- ds50010--------
    rs713061181,2
    C--51166540(-) CTTCA-/CT/TC 
            
    TCTCT
    1 -- int11NA 2
    rs719640581,2
    C--51167179(+) TCTTT-/T/TC  
            
    CTCTC
    1 -- int10--------
    rs1810102991,2
    --51173774(+) TCCCTA/CCTCTG 1 -- int10--------
    rs1149975611,2
    F--51173885(+) CCCTCA/GTGTCC 1 -- int11Minor allele frequency- G:0.06WA 118
    rs743711151,2
    C--51173908(+) CCCCT-/GGCTAC 1 -- int10--------
    rs359460351,2
    C--51173909(+) CCCCT-/GCTACA 1 -- int10--------

    HapMap Linkage Disequilibrium report for SHANK1 (51165084 - 51222707 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SHANK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718745CNV Deletion23290073
    esv2718747CNV Deletion23290073
    esv2718744CNV Deletion23290073
    esv2718746CNV Deletion23290073
    nsv912287CNV Loss21882294
    nsv912286CNV Loss21882294
    nsv828583CNV Loss20364138
    nsv912285CNV Loss21882294

    Human Gene Mutation Database (HGMD): SHANK1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SHANK1
    DNA2.0 Custom Variant and Variant Library Synthesis for SHANK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604999    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for SHANK1:
    Autistic disorder

    Find genes that share disorders with SHANK1           About GenesLikeMe


    Export disorders for SHANK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SHANK1 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with SHANK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain. (PubMed id 10551867)1, 2, 3, 9 Zitzer H.... Kreienkamp H.-J. (J. Biol. Chem. 1999)
    2. The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42. (PubMed id 12504591)1, 2 Soltau M.... Kreienkamp H.-J. (Mol. Cell. Neurosci. 2002)
    3. The Shank family of scaffold proteins. (PubMed id 10806096)1, 2 Sheng M. and Kim E. (J. Cell Sci. 2000)
    4. Shank1 mRNA: dendritic transport by kinesin and translational control by the 5'untranslated region. (PubMed id 19416473)1, 9 Falley K....Kreienkamp H.J. (Traffic 2009)
    5. Identification of proteins interacting with the rat somatostatin receptor subtype 2. (PubMed id 11087996)1, 9 Kreienkamp H.J....Richter D. (J. Physiol. Paris 2000)
    6. A promoter variant of SHANK1 affects auditory working memory in schizophrenia patients and in subjects clinically at risk for psychosis. (PubMed id 21901269)1 Lennertz L....MAPssner R. (Eur Arch Psychiatry Clin Neurosci 2012)
    7. SHANK1 Deletions in Males with Autism Spectrum Disorder. (PubMed id 22503632)1 Sato D....Scherer S.W. (Am. J. Hum. Genet. 2012)
    8. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    9. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50944 HGNC: 15474 AceView: SHANK1 Ensembl:ENSG00000161681 euGenes: HUgn50944
    ECgene: SHANK1 Kegg: 50944 H-InvDB: SHANK1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SHANK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SHANK1 gene:
    Search GeneIP for patents involving SHANK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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