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Aliases for SH3YL1 Gene

Aliases for SH3YL1 Gene

  • SH3 And SYLF Domain Containing 1 2 3 5
  • SH3 Domain Containing, Ysc84-Like 1 (S. Cerevisiae) 2
  • SH3 Domain-Containing YSC84-Like Protein 1 3
  • SH3 Domain Containing, Ysc84-Like 1 3
  • RAY 3

External Ids for SH3YL1 Gene

Previous GeneCards Identifiers for SH3YL1 Gene

  • GC02M000212

Summaries for SH3YL1 Gene

GeneCards Summary for SH3YL1 Gene

SH3YL1 (SH3 And SYLF Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol binding and phosphatase binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3YL1 Gene

Genomics for SH3YL1 Gene

Regulatory Elements for SH3YL1 Gene

Enhancers for SH3YL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SH3YL1 on UCSC Golden Path with GeneCards custom track

Promoters for SH3YL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SH3YL1 Gene

Chromosome:
2
Start:
217,730 bp from pter
End:
266,398 bp from pter
Size:
48,669 bases
Orientation:
Minus strand

Genomic View for SH3YL1 Gene

Genes around SH3YL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3YL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3YL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3YL1 Gene

Proteins for SH3YL1 Gene

  • Protein details for SH3YL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HL8-SH3Y1_HUMAN
    Recommended name:
    SH3 domain-containing YSC84-like protein 1
    Protein Accession:
    Q96HL8
    Secondary Accessions:
    • A8K8E7
    • B7WNJ4
    • B7WPL6
    • Q8NEL2
    • Q9H5X4
    • Q9Y3V5

    Protein attributes for SH3YL1 Gene

    Size:
    342 amino acids
    Molecular mass:
    37148 Da
    Quaternary structure:
    • Interacts with SH3D19.

    Three dimensional structures from OCA and Proteopedia for SH3YL1 Gene

    Alternative splice isoforms for SH3YL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH3YL1 Gene

Post-translational modifications for SH3YL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SH3YL1 Gene

Domains & Families for SH3YL1 Gene

Protein Domains for SH3YL1 Gene

Suggested Antigen Peptide Sequences for SH3YL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96HL8

UniProtKB/Swiss-Prot:

SH3Y1_HUMAN :
  • Contains 1 SH3 domain.
  • Belongs to the SH3YL1 family.
Domain:
  • Contains 1 SH3 domain.
Family:
  • Belongs to the SH3YL1 family.
genes like me logo Genes that share domains with SH3YL1: view

No data available for Gene Families for SH3YL1 Gene

Function for SH3YL1 Gene

Gene Ontology (GO) - Molecular Function for SH3YL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0019902 phosphatase binding IDA 21624956
GO:0035091 phosphatidylinositol binding IDA 21624956
genes like me logo Genes that share ontologies with SH3YL1: view
genes like me logo Genes that share phenotypes with SH3YL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SH3YL1 Gene

Localization for SH3YL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SH3YL1 Gene COMPARTMENTS Subcellular localization image for SH3YL1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for SH3YL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032587 ruffle membrane IDA 21624956
genes like me logo Genes that share ontologies with SH3YL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SH3YL1 Gene

Pathways & Interactions for SH3YL1 Gene

SuperPathways for SH3YL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SH3YL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006661 phosphatidylinositol biosynthetic process IEA --
GO:1900027 regulation of ruffle assembly IBA --
genes like me logo Genes that share ontologies with SH3YL1: view

No data available for Pathways by source and SIGNOR curated interactions for SH3YL1 Gene

Drugs & Compounds for SH3YL1 Gene

No Compound Related Data Available

Transcripts for SH3YL1 Gene

Unigene Clusters for SH3YL1 Gene

SH3 domain containing, Ysc84-like 1 (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3YL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c · 15d · 15e ^ 16 ^
SP1: - - - - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - - -
SP8: - - - -
SP9: - - -
SP10:
SP11: -

ExUns: 17 ^ 18 ^ 19a · 19b · 19c
SP1: -
SP2: - -
SP3: - -
SP4: -
SP5: - -
SP6:
SP7:
SP8: - -
SP9:
SP10:
SP11:

Relevant External Links for SH3YL1 Gene

GeneLoc Exon Structure for
SH3YL1
ECgene alternative splicing isoforms for
SH3YL1

Expression for SH3YL1 Gene

mRNA expression in normal human tissues for SH3YL1 Gene

Protein differential expression in normal tissues from HIPED for SH3YL1 Gene

This gene is overexpressed in Salivary gland (59.4) and Placenta (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SH3YL1 Gene



Protein tissue co-expression partners for SH3YL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SH3YL1 Gene:

SH3YL1

SOURCE GeneReport for Unigene cluster for SH3YL1 Gene:

Hs.515951
genes like me logo Genes that share expression patterns with SH3YL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SH3YL1 Gene

Orthologs for SH3YL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SH3YL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SH3YL1 34
  • 87.1 (n)
  • 93.55 (a)
SH3YL1 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SH3YL1 34
  • 86.94 (n)
  • 90.64 (a)
SH3YL1 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sh3yl1 34
  • 86.37 (n)
  • 92.94 (a)
Sh3yl1 16
Sh3yl1 35
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SH3YL1 34
  • 99.28 (n)
  • 99.69 (a)
SH3YL1 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sh3yl1 34
  • 85.88 (n)
  • 92.94 (a)
oppossum
(Monodelphis domestica)
Mammalia SH3YL1 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 91 (a)
OneToMany
-- 35
  • 82 (a)
OneToMany
chicken
(Gallus gallus)
Aves SH3YL1 34
  • 74.92 (n)
  • 77.64 (a)
SH3YL1 35
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SH3YL1 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3yl1 34
  • 75.29 (n)
  • 87.07 (a)
zebrafish
(Danio rerio)
Actinopterygii sh3yl1 34
  • 62.66 (n)
  • 67.27 (a)
sh3yl1 35
  • 64 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL017W 34
  • 48.93 (n)
  • 47.55 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A08360g 34
  • 55.28 (n)
  • 51.76 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YSC84 35
  • 34 (a)
OneToMany
LSB3 35
  • 34 (a)
OneToMany
LSB3 34
  • 54.28 (n)
  • 53.16 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03888 34
  • 57.2 (n)
  • 57.58 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAPJ696.02 34
  • 56.55 (n)
  • 51.79 (a)
Species where no ortholog for SH3YL1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SH3YL1 Gene

ENSEMBL:
Gene Tree for SH3YL1 (if available)
TreeFam:
Gene Tree for SH3YL1 (if available)

Paralogs for SH3YL1 Gene

(4) SIMAP similar genes for SH3YL1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SH3YL1: view

No data available for Paralogs for SH3YL1 Gene

Variants for SH3YL1 Gene

Sequence variations from dbSNP and Humsavar for SH3YL1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1046207 -- 218,476(-) GTAGA(C/G)CCACA nc-transcript-variant, utr-variant-3-prime
rs1128906 -- 233,218(-) GGAAG(A/G)AAACG nc-transcript-variant, reference, missense
rs4455191 -- 256,278(+) TCTAA(C/T)GTGTG intron-variant, utr-variant-5-prime
rs9213 -- 218,386(-) AGAGT(C/T)GTAGG nc-transcript-variant, utr-variant-3-prime
rs6710091 -- 239,597(+) TGATT(C/G)AGGAA intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for SH3YL1 Gene

Variant ID Type Subtype PubMed ID
dgv3694n100 CNV loss 25217958
dgv3695n100 CNV gain 25217958
esv1237216 CNV deletion 17803354
esv1550511 CNV deletion 17803354
esv2751887 CNV loss 17911159
esv2759016 CNV gain 17122850
esv2760594 CNV loss 21179565
esv3589595 CNV loss 21293372
esv3589598 CNV gain 21293372
esv3589599 CNV gain 21293372
esv994728 CNV deletion 20482838
nsv1006547 CNV gain 25217958
nsv1007793 CNV gain 25217958
nsv2561 CNV insertion 18451855
nsv508735 CNV insertion 20534489
nsv519763 CNV loss 19592680
nsv580421 CNV loss 21841781
nsv833148 CNV loss 17160897
nsv833159 CNV loss 17160897

Variation tolerance for SH3YL1 Gene

Residual Variation Intolerance Score: 81.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH3YL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SH3YL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3YL1 Gene

Disorders for SH3YL1 Gene

Relevant External Links for SH3YL1

Genetic Association Database (GAD)
SH3YL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SH3YL1

No disorders were found for SH3YL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3YL1 Gene

Publications for SH3YL1 Gene

  1. SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain. (PMID: 21624956) Hasegawa J. … Itoh T. (J. Cell Biol. 2011) 2 3 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus. (PMID: 26305679) Blessing A.M. … Frigo D.E. (Mol. Endocrinol. 2015) 3 65
  4. Dock4 forms a complex with SH3YL1 and regulates cancer cell migration. (PMID: 24508479) Kobayashi M. … Katoh H. (Cell. Signal. 2014) 3 65
  5. A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels. (PMID: 25240745) LA^pez S. … Soria J.M. (Mitochondrion 2014) 3 65

Products for SH3YL1 Gene

Sources for SH3YL1 Gene

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