Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SH3YL1 Gene

protein-coding   GIFtS: 47
GCID: GC02M000208

SH3 domain containing, Ysc84-like 1 (S. cerevisiae)

 Explore 1 disease affiliated with
SH3YL1 via our new
 Human Malady Compendium 
Biological research products
for SH3YL1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
SH3 Domain Containing, Ysc84-Like 1 (S. Cerevisiae)1 2
DKFZP586F13181
Ray1
RAY2
SH3 Domain-Containing YSC84-Like Protein 12

External Ids:    HGNC: 295461   Entrez Gene: 267512   Ensembl: ENSG000000351157   UniProtKB: Q96HL83   

Export aliases for SH3YL1 gene to outside databases

Previous GC identifer: GC02M000212


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022221.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SH3YL1 gene promoter:
         STAT5B   p53   Pax-2   STAT3   Pax-2a   Meis-1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSH3YL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SH3YL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH3YL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.3   Ensembl cytogenetic band:  2p25.3   HGNC cytogenetic band: 2p25.3

SH3YL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SH3YL1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M000208:  view genomic region     (about GC identifiers)

Start:
217,730 bp from pter      End:
266,398 bp from pter
Size:
48,669 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SH3Y1_HUMAN, Q96HL8 (See protein sequence)
Recommended Name: SH3 domain-containing YSC84-like protein 1  
Size: 342 amino acids; 37148 Da
Subunit: Interacts with SH3D19 (By similarity)
1 PDB 3D structure from and Proteopedia for SH3YL1:
2D8H (3D)    
Secondary accessions: A8K8E7 B7WNJ4 B7WPL6 Q8NEL2 Q9H5X4 Q9Y3V5
Alternative splicing: 5 isoforms:  Q96HL8-1   Q96HL8-2   Q96HL8-3   Q96HL8-4   Q96HL8-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SH3YL1: NX_Q96HL8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96HL8

  • SH3YL1 Protein expression data from MOPED and PaxDb:    About this image 
    SH3YL1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001153069.1  NP_056492.2  

    ENSEMBL proteins: 
     ENSP00000384276   ENSP00000385668   ENSP00000384269   ENSP00000348471   ENSP00000383928  
     ENSP00000441266   ENSP00000416312   ENSP00000399519   ENSP00000415723   ENSP00000384910  
     ENSP00000410235   ENSP00000404143  

    Human Recombinant Protein Products for SH3YL1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: SH3YL1
    OriGene Custom Protein Services for SH3YL1 
    GenScript Custom Purified and Recombinant Proteins Services for SH3YL1
    Novus Biologicals SH3YL1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SH3YL1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032587ruffle membrane IDA--

    SH3YL1 for ontologies           About GeneDecksing



    SH3YL1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SH3YL1 
    GenScript Custom Superior Antibodies Services for SH3YL1
    Novus Biologicals SH3YL1 Antibodies
    Abcam antibodies for SH3YL1 
    Uscn Antibodies for SH3YL1
    Search ThermoFisher Antibodies for SH3YL1

    Assay Products for SH3YL1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SH3YL1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SH3YL1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SH3YL1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001452 SH3_domain
     IPR007461 Ysc84_actin-binding

    Graphical View of Domain Structure for InterPro Entry Q96HL8

    ProtoNet protein and cluster: Q96HL8

    1 Blocks protein family: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: SH3Y1_HUMAN, Q96HL8
    Similarity: Belongs to the SH3YL1 family
    Similarity: Contains 1 SH3 domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0019902phosphatase binding IDA--
    GO:0035091phosphatidylinositol binding IDA--
         
    SH3YL1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SH3YL1 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 2): SH3YL1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SH3YL1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SH3YL1
    SwitchGear 3'UTR luciferase reporter plasmidSH3YL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SH3YL1 (see all 7)
    OriGene shRNA RFP: SH3YL1
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SH3YL1
    Sirion Biotech Custom design and validation of potent shRNA sequences against SH3YL1 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SH3YL1
    Sirion Biotech Customized adenovirus for overexpression of SH3YL1 
    Sirion Biotech Customized adenovirus for potent knockdown of SH3YL1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH3YL1 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH3YL1 (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SH3YL1 (NM_015677)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SH3YL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH3YL1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SH3YL1
    Search LifeMap BioReagents cell lines for SH3YL1
    Sirion Biotech Customized stable knockdown cell line services for SH3YL1 
    Sirion Biotech Customized inducible knockdown cell line services for SH3YL1
    Sirion Biotech Customized stable overexpressing cell line services for SH3YL1
    Sirion Biotech Customized inducible overexpressing cell line services for SH3YL1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3YL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SH3YL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/33 Interacting proteins for SH3YL1 (Q96HL82, 3 ENSP000004041434) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFAPP141362, 3, ENSP000002534084MINT-67449 I2D: score=5 STRING: ENSP00000253408
    VIMP086702, 3, ENSP000002242374MINT-65852 I2D: score=5 STRING: ENSP00000224237
    SH3D19Q5HYK73, ENSP000003029134I2D: score=3 STRING: ENSP00000302913
    HELZP426943, ENSP000003515244I2D: score=1 STRING: ENSP00000351524
    EVI5LQ96CN43I2D: score=6 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006661phosphatidylinositol biosynthetic process IEA--
    GO:1900027regulation of ruffle assembly IEA--

    SH3YL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SH3YL1
    Search CenterWatch for drugs/clinical trials and news about SH3YL1 / SH3Y1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SH3YL1 gene (2 alternative transcripts): 
    NM_001159597.1  NM_015677.2  

    Unigene Cluster for SH3YL1:

    SH3 domain containing, Ysc84-like 1 (S. cerevisiae)
    Hs.515951  [show with all ESTs]
    Unigene Representative Sequence: AK123829
    18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000460974 ENST00000403712 ENST00000463865(uc002qvz.3) ENST00000403657(uc002qvv.3 uc002qvw.3 uc010ewe.3)
    ENST00000473104(uc002qwc.1) ENST00000405430 ENST00000356150(uc002qvx.3 uc002qvy.3)
    ENST00000403658 ENST00000468321(uc002qwa.3) ENST00000479739 ENST00000451005
    ENST00000472012 ENST00000431160 ENST00000471948 ENST00000481932 ENST00000488044
    ENST00000497051 ENST00000488979

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 2): SH3YL1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SH3YL1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SH3YL1
    SwitchGear 3'UTR luciferase reporter plasmidSH3YL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SH3YL1 (see all 7)
    OriGene shRNA RFP: SH3YL1
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SH3YL1
    Sirion Biotech Custom design and validation of potent shRNA sequences against SH3YL1 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH3YL1 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH3YL1 (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SH3YL1 (NM_015677)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SH3YL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH3YL1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SH3YL1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SH3YL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SH3YL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SH3YL1

    Additional cDNA sequence: 

    AK026507.1 AK026586.1 AK055801.1 AK096440.1 AK123829.1 AK292312.1 AL050373.1 BC008374.1 
    BC008375.1 BC013286.1 BC030778.1 BC034974.1 BC043234.1 BC043403.1 CR457361.1 

    24/29 DOTS entries (see all 29):

    DT.99984839  DT.100812716  DT.115626  DT.100030203  DT.100024587  DT.95254819  DT.91969003  DT.100802905 
    DT.40129436  DT.95297589  DT.121013659  DT.97844160  DT.100812715  DT.100812717  DT.95297599  DT.121013793 
    DT.91965837  DT.95297603  DT.75188006  DT.75141062  DT.97844156  DT.100720652  DT.121013734  DT.121013801 

    24/253 AceView cDNA sequences (see all 253):

    BQ420455 CK821806 BC043234 BQ065806 CR457361 BC008374 CD723378 BQ632093 
    CD369140 AA988603 AA233187 AA977884 BU076045 BM973895 CR595739 AL699139 
    AI696576 BG661324 BF111461 AA494108 AI373730 AI569539 BM480034 AA421414 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SH3YL1 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c · 15d · 15e ^ 16 ^
    SP1:              -     -     -                             -                             -     -                                         -     -     -         
    SP2:                                      -     -           -                                   -                                         -     -     -         
    SP3:                                                        -                                                                                   -     -         
    SP4:                    -     -     -     -     -     -     -                             -     -                                         -     -     -         
    SP5:                          -     -     -     -     -     -                             -     -                                         -     -     -         

    ExUns: 17 ^ 18 ^ 19a · 19b · 19c
    SP1:        -                     
    SP2:  -     -                     
    SP3:  -     -                     
    SP4:        -                     
    SP5:  -     -                     


    ECgene alternative splicing isoforms for SH3YL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SH3YL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTAGACTTGT
    SH3YL1 Expression
    About this image
    See SH3YL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SH3YL1

    SOURCE GeneReport for Unigene cluster: Hs.515951
        SABiosciences Custom PCR Arrays for SH3YL1

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SH3YL1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SH3YL1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SH3YL1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SH3YL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3YL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SH3YL1 gene from 7/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sh3yl11 , 5 Sh3 domain YSC-like 11, 5 86.4(n)1
    93.46(a)1
      12 (13.01 cM)5
    240571  NM_013709.41  NP_038737.11 
     309116685 
    chicken
    (Gallus gallus)
    Aves SH3YL11 SH3 domain containing, Ysc84-like 1 (S. cerevisiae) 75.21(n)
    79.06(a)
      421908  XM_419926.2  XP_419926.1 
    lizard
    (Anolis carolinensis)
    Reptilia SH3YL16
    --
    73(a)
    1 ↔ 1
    1(160038321-160066909)
    zebrafish
    (Danio rerio)
    Actinopterygii sh3yl11 SH3 domain containing, Ysc84-like 1 (S. cerevisiae) 64.67(n)
    70.03(a)
      566522  XM_689794.5  XP_694886.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YSC841 Ysc84p 53.5(n)
    52.9(a)
      856409   NP_011880.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G432306
    AT1G298006
    RING/FYVE/PHD zinc finger-containing protein
    18(a)
    16(a)
    many → 1
    many → 1
    3(15207367-15209825)
    1(10432601-10435441)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 4)
    FYVE zinc finger domain containing protein, expres...
    FYVE zinc finger domain containing protein, expres...
    (see all 4)
    19(a)
    18(a)
    (see all 4)
    many → 1
    many → 1
    (see all 4)
    7(25434737-25438807)
    7(10063213-10067029)


    ENSEMBL Gene Tree for SH3YL1 (if available)
    TreeFam Gene Tree for SH3YL1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/739 NCBI SNPs in SH3YL1 are shown (see all 739    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1437692431,2
    --217754(+) ATGGGG/TGAGCG 2 -- int10--------
    rs1808705471,2
    --217758(+) GGGAGA/CGCAAA 2 -- int10--------
    rs1500827091,2
    --217809(+) GTGGAC/TTTAAT 2 -- int10--------
    rs67102331,2
    C,F,A,H--217826(+) CATGAG/CATAGA 2 -- int112Minor allele frequency- C:0.39NS EA NA WA CSA 786
    rs1857141621,2
    --217834(+) AGAAGA/GACGAA 2 -- int10--------
    rs1383675751,2
    --217921(+) GGAGGA/GGCAGG 2 -- int10--------
    rs1492498761,2
    --218093(+) AGACAC/TAGGAC 2 -- int10--------
    rs1905715431,2
    --218152(+) ACTTAC/GTAAAC 2 -- ut310--------
    rs1444742601,2
    --218165(+) TTAAAA/TATTTT 2 -- ut310--------
    rs755222351,2
    --218198(+) TCACCA/GTAAGT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SH3YL1 (217730 - 266398 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for SH3YL1
         4 CNVs: 2360 50561 3341 8936
         2 Indels: 26578 26576

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SH3YL1
    DNA2.0 Custom Variant and Variant Library Synthesis for SH3YL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SH3YL1 for disorders           About GeneDecksing

    1 disease for SH3YL1:    About MalaCards
    wiskott-aldrich syndrome


    Export disorders for SH3YL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SH3YL1 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with SH3YL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Comprehensive analysis of interactions between the Src -associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome. (PubMed id 22745667)1 Asbach B....Wagner R. (2012)
    4. SH3YL1 regulates dorsal ruffle formation by a novel p hosphoinositide-binding domain. (PubMed id 21624956)1 Hasegawa J....Itoh T. (2011)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    10. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26751 HGNC: 29546 AceView: SH3YL1 Ensembl:ENSG00000035115 euGenes: HUgn26751
    ECgene: SH3YL1 H-InvDB: SH3YL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SH3YL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SH3YL1 gene:
    Search GeneIP for patents involving SH3YL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SH3YL1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SH3YL1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SH3YL1  
     OriGene Protein Over-expression Lysate for SH3YL1   Browse OriGene Fluorogenic Cell Assay Kits  
     Browse OriGene siRNAs   OriGene 3'-UTR Clone for SH3YL1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH3YL1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH3YL1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SH3YL1   OriGene Custom Protein Services for SH3YL1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SH3YL1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SH3YL1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH3YL1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SH3YL1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SH3YL1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SH3YL1
     GenScript Custom Purified and Recombinant Proteins Services for SH3YL1 GenScript cDNA clones with any tag delivered in your preferred vector for SH3YL1
     GenScript Custom Assay Services for SH3YL1 GenScript Custom Superior Antibodies Services for SH3YL1
     GenScript Custom overexpressing Cell Line Services for SH3YL1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SH3YL1 promoter
     Search Chromatin IP Primers for SH3YL1
     RT2 qPCR Primer Assay in human, mouse, rat SH3YL1
     Search GNC Networks for SH3YL1
     SABiosciences Custom PCR Arrays for SH3YL1
     Search Tocris compounds for SH3YL1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SH3YL1 antibodies
     SH3YL1 proteins
     Antibodies for SH3YL1
     See all of Abcam's Antibodies, Kits and Proteins for SH3YL1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SH3YL1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SH3YL1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3YL1
     SwitchGear 3'UTR luciferase reporter plasmids for SH3YL1
     SwitchGear Promoter luciferase reporter plasmids for SH3YL1
     Search ThermoFisher Antibodies for SH3YL1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH3YL1
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SH3YL1
    Sirion Biotech Customized:
     stable knockdown cell line services for SH3YL1
     inducible knockdown cell line services for SH3YL1
     design and validation of potent shRNA sequences against SH3YL1
     adenovirus for potent knockdown of SH3YL1
     adenovirus for overexpression of SH3YL1
     stable overexpressing cell line services for SH3YL1
     inducible overexpressing cell line services for SH3YL1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SH3YL1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4