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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SH3TC1 Gene

protein-coding   GIFtS: 44
GCID: GC04P008183

SH3 domain and tetratricopeptide repeats 1

  Search for SH3TC1
in our new
 Human Malady Compendium 
Biological research products
for SH3TC1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
SH3 Domain And Tetratricopeptide Repeats 11 2
FLJ203561
SH3 Domain And Tetratricopeptide Repeat-Containing Protein 12
SH3 Domain And Tetratricopeptide Repeats-Containing Protein 12

External Ids:    HGNC: 260091   Entrez Gene: 544362   Ensembl: ENSG000001250897   UniProtKB: Q8TE823   

Export aliases for SH3TC1 gene to outside databases

Previous GC identifers: GC04P008393 GC04P008319 GC04P008251 GC04P008201 GC04P008120


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006051.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SH3TC1 gene promoter:
         POU3F1   Pax-6   Lmo2   NF-kappaB   E47   NF-kappaB2   Hand1   Chx10   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSH3TC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SH3TC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH3TC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16.1

SH3TC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SH3TC1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P008183:  view genomic region     (about GC identifiers)

Start:
8,183,799 bp from pter      End:
8,242,830 bp from pter
Size:
59,032 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S3TC1_HUMAN, Q8TE82 (See protein sequence)
Recommended Name: SH3 domain and tetratricopeptide repeat-containing protein 1  
Size: 1336 amino acids; 146961 Da
Secondary accessions: Q4W5G5

Explore the universe of human proteins at neXtProt for SH3TC1: NX_Q8TE82

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TE82

  • SH3TC1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_061859.3  
    ENSEMBL proteins: 
     ENSP00000422315   ENSP00000425970   ENSP00000371961   ENSP00000245105   ENSP00000390311  
     ENSP00000425079   ENSP00000427316   ENSP00000426035   ENSP00000423583   ENSP00000441045  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SH3TC1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--


    SH3TC1 for ontologies           About GeneDecksing



    SH3TC1 Antibody Products: 
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    Uscn ELISAs and CLIAs for SH3TC1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SH3TC1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011990 TPR-like_helical
     IPR001452 SH3_domain
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry Q8TE82

    ProtoNet protein and cluster: Q8TE82

    1 Blocks protein family: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: S3TC1_HUMAN, Q8TE82
    Similarity: Contains 1 SH3 domain
    Similarity: Contains 9 TPR repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3TC1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SH3TC1

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--


    SH3TC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SH3TC1
    Search CenterWatch for drugs/clinical trials and news about SH3TC1 / S3TC1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SH3TC1 gene: 
    NM_018986.3  

    Unigene Cluster for SH3TC1:

    SH3 domain and tetratricopeptide repeats 1
    Hs.479116  [show with all ESTs]
    Unigene Representative Sequence: AK126165
    18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000510763 ENST00000509119 ENST00000507123 ENST00000506360 ENST00000502669
    ENST00000382521 ENST00000245105(uc003gkv.4 uc003gkx.4) ENST00000457650
    ENST00000515682 ENST00000504822 ENST00000503284 ENST00000504223 ENST00000512100
    ENST00000507891 ENST00000508641 ENST00000514274 ENST00000508438 ENST00000509553


    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SH3TC1 (see all 7)
    OriGene shRNA RFP: SH3TC1
    OriGene siRNA: SH3TC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SH3TC1
    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH3TC1 (see all 3)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SH3TC1
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    Additional cDNA sequence: 

    AK000363.1 AK074402.1 AK126165.1 AK222865.1 AK310552.1 BC028011.1 BC030283.1 BC068094.1 
    BC131785.1 

    16 DOTS entries:

    DT.211037  DT.100775296  DT.99948038  DT.40269465  DT.101975261  DT.121232430  DT.100025933  DT.121232450 
    DT.121232461  DT.95197788  DT.100745235  DT.121232444  DT.121232446  DT.92420813  DT.91652509  DT.91704735 

    24/134 AceView cDNA sequences (see all 134):

    CK824904 AI017843 CA772430 BP373081 AA020913 BX483858 AI739264 BM264617 
    AA300200 CK824905 AI733671 BX100810 AI261362 BC068094 AW055222 AI479274 
    AI913259 AI439165 BM128923 CA488989 CA776992 AA380624 AI719732 AA514482 

    GeneLoc Exon Structure

    5/22 Alternative Splicing Database (ASD) splice patterns (SP) for SH3TC1 (see all 22)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14a · 14b ^ 15 ^ 16a ·
    SP1:              -     -                 -     -                             -                       -                                               -     -   
    SP2:              -     -                 -                                   -                       -                                               -     -   
    SP3:              -     -                 -                                   -                 -                                                     -     -   
    SP4:                                                                                                                                                            
    SP5:                                                                          -                 -     -                                                         

    ExUns: 16b ^ 17a · 17b · 17c · 17d ^ 18 ^ 19a · 19b · 19c ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b · 24c ^ 25a · 25b ^ 26a · 26b · 26c ^ 27a · 27b ^ 28 ^ 29a ·
    SP1:        -                             -     -     -     -     -                 -     -     -     -     -                 -     -                           
    SP2:        -                             -     -     -     -     -                 -     -     -     -     -                 -     -                           
    SP3:        -                             -     -     -     -     -                                                           -     -                           
    SP4:                                                        -     -                                                           -     -                           
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for SH3TC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SH3TC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCGAGCTGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    SH3TC1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SH3TC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SH3TC1

    SOURCE GeneReport for Unigene cluster: Hs.479116
        SABiosciences Custom PCR Arrays for SH3TC1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3TC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SH3TC1 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SH3TC11 SH3 domain and tetratricopeptide repeats 1 58.23(n)
    56.9(a)
      422867  XM_420812.3  XP_420812.2 
    lizard
    (Anolis carolinensis)
    Reptilia SH3TC16
    --
    50(a)
    1 ↔ 1
    GL343236.1(1514911-1551869)
    zebrafish
    (Danio rerio)
    Actinopterygii sh3tc11 SH3 domain and tetratricopeptide repeats 1 56.46(n)
    49.82(a)
      100535608  XM_003199008.1  XP_003199056.1 


    ENSEMBL Gene Tree for SH3TC1 (if available)
    TreeFam Gene Tree for SH3TC1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SH3TC1 gene
    SH3TC22  
    2 SIMAP similar genes for SH3TC1 using alignment to 13 protein entries:     S3TC1_HUMAN (see all proteins):
    FLJ00164    SH3TC2

    SH3TC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for SH3TC1
         3 CNVs: 30200 4375 30199
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SH3TC1
    DNA2.0 Custom Variant and Variant Library Synthesis for SH3TC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SH3TC1 for disorders           About MalaCards

    SH3TC1 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: SH3TC1 (2 documents)

    Export disorders for SH3TC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SH3TC1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SH3TC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    3. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
    4. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    5. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54436 HGNC: 26009 AceView: SH3TC1 Ensembl:ENSG00000125089 euGenes: HUgn54436
    ECgene: SH3TC1 H-InvDB: SH3TC1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SH3TC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SH3TC1 gene:
    Search GeneIP for patents involving SH3TC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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