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Aliases for SH3TC1 Gene

Aliases for SH3TC1 Gene

  • SH3 Domain And Tetratricopeptide Repeats 1 2 3 5

External Ids for SH3TC1 Gene

Previous GeneCards Identifiers for SH3TC1 Gene

  • GC04P008393
  • GC04P008319
  • GC04P008251
  • GC04P008201
  • GC04P008120

Summaries for SH3TC1 Gene

GeneCards Summary for SH3TC1 Gene

SH3TC1 (SH3 Domain And Tetratricopeptide Repeats 1) is a Protein Coding gene. An important paralog of this gene is SH3TC2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3TC1 Gene

Genomics for SH3TC1 Gene

Regulatory Elements for SH3TC1 Gene

Enhancers for SH3TC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SH3TC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SH3TC1 Gene

Chromosome:
4
Start:
8,182,072 bp from pter
End:
8,241,803 bp from pter
Size:
59,732 bases
Orientation:
Plus strand

Genomic View for SH3TC1 Gene

Genes around SH3TC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3TC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3TC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3TC1 Gene

Proteins for SH3TC1 Gene

  • Protein details for SH3TC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TE82-S3TC1_HUMAN
    Recommended name:
    SH3 domain and tetratricopeptide repeat-containing protein 1
    Protein Accession:
    Q8TE82
    Secondary Accessions:
    • Q4W5G5

    Protein attributes for SH3TC1 Gene

    Size:
    1336 amino acids
    Molecular mass:
    146961 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SH3TC1 Gene

Post-translational modifications for SH3TC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SH3TC1 Gene

Domains & Families for SH3TC1 Gene

Gene Families for SH3TC1 Gene

Protein Domains for SH3TC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TE82

UniProtKB/Swiss-Prot:

S3TC1_HUMAN :
  • Contains 1 SH3 domain.
  • Contains 9 TPR repeats.
Domain:
  • Contains 1 SH3 domain.
Similarity:
  • Contains 9 TPR repeats.
genes like me logo Genes that share domains with SH3TC1: view

Function for SH3TC1 Gene

genes like me logo Genes that share phenotypes with SH3TC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SH3TC1 Gene

Localization for SH3TC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SH3TC1 Gene COMPARTMENTS Subcellular localization image for SH3TC1 gene
Compartment Confidence
cytosol 3
nucleus 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for SH3TC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with SH3TC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SH3TC1 Gene

Pathways & Interactions for SH3TC1 Gene

SuperPathways for SH3TC1 Gene

No Data Available

Interacting Proteins for SH3TC1 Gene

Selected Interacting proteins: Q8TE82-S3TC1_HUMAN for SH3TC1 Gene via IID

Symbol External ID(s) Details
ATF6
DENND3

Gene Ontology (GO) - Biological Process for SH3TC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SH3TC1: view

No data available for Pathways by source and SIGNOR curated interactions for SH3TC1 Gene

Drugs & Compounds for SH3TC1 Gene

No Compound Related Data Available

Transcripts for SH3TC1 Gene

Unigene Clusters for SH3TC1 Gene

SH3 domain and tetratricopeptide repeats 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3TC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14a · 14b ^ 15 ^ 16a ·
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4:
SP5: - - -
SP6: -
SP7: - - -
SP8: - - - - - -
SP9:
SP10:
SP11: - -
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17: - -
SP18:
SP19:
SP20:
SP21:
SP22: -

ExUns: 16b ^ 17a · 17b · 17c · 17d ^ 18 ^ 19a · 19b · 19c ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b · 24c ^ 25a · 25b ^ 26a · 26b · 26c ^ 27a · 27b ^ 28 ^ 29a ·
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9: - - - - - - - - -
SP10: - - - - -
SP11:
SP12: - - - - - - -
SP13: - - - - - -
SP14: - - - - - -
SP15: - - - - -
SP16: -
SP17:
SP18: - - - - - -
SP19: - - -
SP20:
SP21: -
SP22:

Relevant External Links for SH3TC1 Gene

GeneLoc Exon Structure for
SH3TC1
ECgene alternative splicing isoforms for
SH3TC1

Expression for SH3TC1 Gene

mRNA expression in normal human tissues for SH3TC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH3TC1 Gene

This gene is overexpressed in Whole Blood (x5.2) and Kidney - Cortex (x4.8).

Protein differential expression in normal tissues from HIPED for SH3TC1 Gene

This gene is overexpressed in Lung (19.0), Heart (18.4), Peripheral blood mononuclear cells (9.5), and Placenta (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SH3TC1 Gene



NURSA nuclear receptor signaling pathways regulating expression of SH3TC1 Gene:

SH3TC1

SOURCE GeneReport for Unigene cluster for SH3TC1 Gene:

Hs.479116
genes like me logo Genes that share expression patterns with SH3TC1: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SH3TC1 Gene

Orthologs for SH3TC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SH3TC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SH3TC1 34
  • 80.36 (n)
  • 73.36 (a)
SH3TC1 35
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SH3TC1 34
  • 82.41 (n)
  • 78.11 (a)
SH3TC1 35
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sh3tc1 34
  • 78.07 (n)
  • 74.31 (a)
Sh3tc1 16
Sh3tc1 35
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SH3TC1 34
  • 98.04 (n)
  • 98.25 (a)
SH3TC1 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sh3tc1 34
  • 77.68 (n)
  • 74.39 (a)
oppossum
(Monodelphis domestica)
Mammalia SH3TC1 35
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SH3TC1 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves SH3TC1 34
  • 57.44 (n)
  • 55.35 (a)
SH3TC1 35
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SH3TC1 35
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3tc1 34
  • 56.38 (n)
  • 52.84 (a)
zebrafish
(Danio rerio)
Actinopterygii sh3tc1 34
  • 52.53 (n)
  • 43.99 (a)
CR382383.3 35
  • 26 (a)
OneToMany
SH3TC1 (1 of 2) 35
  • 48 (a)
OneToMany
Species where no ortholog for SH3TC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SH3TC1 Gene

ENSEMBL:
Gene Tree for SH3TC1 (if available)
TreeFam:
Gene Tree for SH3TC1 (if available)

Paralogs for SH3TC1 Gene

Paralogs for SH3TC1 Gene

genes like me logo Genes that share paralogs with SH3TC1: view

Variants for SH3TC1 Gene

Sequence variations from dbSNP and Humsavar for SH3TC1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1281149 - 8,228,047(-) GCCGC(A/G)CAGCG reference, missense
rs1281138 - 8,218,302(+) CCATC(A/G)ACGAT reference, missense, utr-variant-5-prime
rs1281145 - 8,227,004(+) GAGCC(C/G/T)GGAGC reference, missense
rs201295499 A colorectal cancer sample 8,227,850(+) CAGCC(A/G/T)CAAGT reference, missense
VAR_035867 A colorectal cancer sample

Structural Variations from Database of Genomic Variants (DGV) for SH3TC1 Gene

Variant ID Type Subtype PubMed ID
dgv2729n106 CNV tandem duplication 24896259
dgv815e201 CNV deletion 23290073
dgv816e201 CNV deletion 23290073
esv2658523 CNV deletion 23128226
esv2763338 CNV gain 21179565
esv3363340 CNV duplication 20981092
esv34196 OTHER inversion 12058347
esv3563373 CNV deletion 23714750
esv3599542 CNV loss 21293372
esv3599543 CNV loss 21293372
nsv1002794 CNV gain 25217958
nsv1009011 CNV loss 25217958
nsv1136814 CNV deletion 24896259
nsv1161031 CNV deletion 26073780
nsv4220 CNV insertion 18451855
nsv461216 CNV loss 19166990
nsv470012 CNV loss 18288195
nsv593626 CNV loss 21841781
nsv593627 CNV gain 21841781
nsv829853 CNV gain+loss 17160897
nsv949784 CNV deletion 24416366

Variation tolerance for SH3TC1 Gene

Residual Variation Intolerance Score: 99.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.13; 95.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH3TC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SH3TC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3TC1 Gene

Disorders for SH3TC1 Gene

Relevant External Links for SH3TC1

Genetic Association Database (GAD)
SH3TC1
Human Genome Epidemiology (HuGE) Navigator
SH3TC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SH3TC1

No disorders were found for SH3TC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3TC1 Gene

Publications for SH3TC1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 65
  5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 65

Products for SH3TC1 Gene

Sources for SH3TC1 Gene

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