SH3TC1 Gene
protein-coding GIFtS : 44
GCID: GC04 P008183
SH3 domain and tetratricopeptide repeats 1
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Aliasesfor SH3TC1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases SH3 Domain And Tetratricopeptide Repeats 1 1 2 FLJ203561 SH3 Domain And Tetratricopeptide Repeat-Containing Protein 12 SH3 Domain And Tetratricopeptide Repeats-Containing Protein 12
Export aliases for SH3TC1 gene to outside databases Previous GC identifers: GC04P008393 GC04P008319 GC04P008251 GC04P008201 GC04P008120
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Summariesfor SH3TC1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor SH3TC1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_006051.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SH3TC1 gene promoter: POU3F1 Pax-6 Lmo2 NF-kappaB E47 NF-kappaB2 Hand1 Chx10 NF-kappaB1 Other transcription factors Search SABiosciences Chromatin IP Primers for SH3TC1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH3TC1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4p16.1 Ensembl cytogenetic band: 4p16.1 HGNC cytogenetic band: 4p16.1 SH3TC1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04P008183: view genomic region
(about GC identifiers )
Start:
8,183,799 bp from pter
End:
8,242,830 bp from pter
Size:
59,032 bases
Orientation:
plus strand
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Proteinsfor SH3TC1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: S3TC1_HUMAN, Q8TE82 (See
protein sequence )Recommended Name: SH3 domain and tetratricopeptide repeat-containing protein 1 Size : 1336 amino acids; 146961 Da
Secondary accessions : Q4W5G5Explore the universe of human proteins at neXtProt for SH3TC1: NX_Q8TE82 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8TE82 SH3TC1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_061859.3 ENSEMBL proteins: ENSP00000422315 ENSP00000425970 ENSP00000371961 ENSP00000245105 ENSP00000390311 ENSP00000425079 ENSP00000427316 ENSP00000426035 ENSP00000423583 ENSP00000441045 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005575 cellular_component
ND --
SH3TC1 for ontologies About GeneDecksing SH3TC1 Antibody Products: Assay Products for SH3TC1:
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Protein
Domains / Familiesfor SH3TC1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SH3TC1 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8TE82 ProtoNet protein and cluster: Q8TE82
1 Blocks protein family : IPB001452 SH3 domain signature UniProtKB/Swiss-Prot: S3TC1_HUMAN, Q8TE82 Similarity : Contains 1 SH3 domainSimilarity : Contains 9 TPR repeats
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Functionfor SH3TC1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SH3TC1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SH3TC1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SH3TC1 (NM_018986 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SH3TC1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SH3TC1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3TC1
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Pathways & Interactionsfor SH3TC1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SH3TC1 Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0008150 biological_process
ND --
SH3TC1 for ontologies About GeneDecksing
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Drugs & Compoundsfor SH3TC1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SH3TC1 Search CenterWatch for drugs/clinical trials and news about SH3TC1 / S3TC1
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Transcriptsfor SH3TC1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SH3TC1 gene: NM_018986.3 Unigene Cluster for SH3TC1:
SH3 domain and tetratricopeptide repeats 1 Hs.479116 [show with all ESTs ] Unigene Representative Sequence: AK126165 18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25 ): ENST00000510763 ENST00000509119 ENST00000507123 ENST00000506360 ENST00000502669 ENST00000382521 ENST00000245105 (uc003gkv.4 uc003gkx.4 ) ENST00000457650 ENST00000515682 ENST00000504822 ENST00000503284 ENST00000504223 ENST00000512100 ENST00000507891 ENST00000508641 ENST00000514274 ENST00000508438 ENST00000509553 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SH3TC1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SH3TC1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SH3TC1 (NM_018986 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SH3TC1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SH3TC1
Additional cDNA sequence: AK000363.1 AK074402.1 AK126165.1 AK222865.1 AK310552.1 BC028011.1 BC030283.1 BC068094.1 BC131785.1
16 DOTS entries : DT.211037 DT.100775296
DT.99948038 DT.40269465 DT.101975261 DT.121232430 DT.100025933 DT.121232450 DT.121232461 DT.95197788 DT.100745235 DT.121232444 DT.121232446 DT.92420813 DT.91652509 DT.91704735 24/134 AceView cDNA sequences (see all 134 ):
CK824904 AI017843 CA772430 BP373081 AA020913 BX483858 AI739264 BM264617 AA300200 CK824905 AI733671 BX100810 AI261362 BC068094 AW055222 AI479274 AI913259 AI439165 BM128923 CA488989 CA776992 AA380624 AI719732 AA514482 GeneLoc Exon Structure 5/22 Alternative Splicing Database (ASD) splice patterns (SP) for SH3TC1 (see all 22 ) About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14a · 14b ^ 15 ^ 16a · SP1 :     -   -       -   -           -         -                 -   -   SP2 :     -   -       -             -         -                 -   -   SP3 :     -   -       -             -       -                   -   -   SP4 :                                                     SP5 :                         -       -   -                    
ExUns: 16b ^ 17a · 17b · 17c · 17d ^ 18 ^ 19a · 19b · 19c ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b · 24c ^ 25a · 25b ^ 26a · 26b · 26c ^ 27a · 27b ^ 28 ^ 29a · SP1 :   -           -   -   -   -   -       -   -   -   -   -       -   -           SP2 :   -           -   -   -   -   -       -   -   -   -   -       -   -           SP3 :   -           -   -   -   -   -                     -   -           SP4 :                   -   -                     -   -           SP5 :                                                    
ECgene alternative splicing isoforms for SH3TC1
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Expression for SH3TC1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SH3TC1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCGAGCTGGC
About this image SH3TC1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See SH3TC1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SH3TC1 SOURCE GeneReport for Unigene cluster: Hs.479116 SABiosciences Custom PCR Arrays for SH3TC1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SH3TC1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SH3TC1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SH3TC1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SH3TC1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3TC1
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Orthologsfor SH3TC1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for SH3TC1 gene from 3/10 species (see all 10 ) About this table
ENSEMBL Gene Tree for SH3TC1 (if available)TreeFam Gene Tree for SH3TC1 (if available)
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Paralogsfor SH3TC1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SH3TC1 gene SH3TC2 2 2 SIMAP similar genes for SH3TC1 using alignment to 13 protein entries: S3TC1_HUMAN (see all proteins ):FLJ00164 SH3TC2
SH3TC1 for paralogs About GeneDecksing
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Genomic Variantsfor SH3TC1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for SH3TC1 3 CNVs : 30200 4375 30199 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SH3TC1
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Disorders
/ Diseasesfor SH3TC1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section SH3TC1 for disorders About MalaCards
SH3TC1 for disorders About GeneDecksing Human Genome Epidemiology (HuGE) Navigator: SH3TC1 (2 documents) Export disorders for SH3TC1 gene to outside databases
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Publicationsfor SH3TC1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SH3TC1 gene integrated from 9 sources : (articles sorted by number of sources associating them with SH3TC1) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061) 1 Trynka G....Wijmenga C. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332) 2 Mayya V.... Han D.K. (2009) The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974) 2 Sjoeblom T.... Velculescu V.E. (2006) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621) 2 Hillier L.W....Wilson R.K. (2005) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298) 1 Maruyama K. and Sugano S. (1994)
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External Searches for SH3TC1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SH3TC1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SH3TC1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing SH3TC1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for SH3TC1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for SH3TC1 gene: Search GeneIP for patents involving SH3TC1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SH3TC1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for SH3TC1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SH3TC1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SH3TC1 OriGene Protein Over-expression Lysate for SH3TC1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SH3TC1 OriGene 3'-UTR Clone for SH3TC1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SH3TC1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SH3TC1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SH3TC1 OriGene Custom Protein Services for SH3TC1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SH3TC1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SH3TC1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH3TC1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SH3TC1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SH3TC1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SH3TC1
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SH3TC1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3TC1
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SH3TC1
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Aliases for SH3TC1
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Disorders / Diseases for SH3TC1
Domains / Families for SH3TC1
Drugs / Compounds for SH3TC1
Expression for SH3TC1
Function for SH3TC1
Genomic Views for SH3TC1
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Pathways / Interactions for SH3TC1
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