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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SH3RF3 Gene

protein-coding   GIFtS: 44
GCID: GC02P109745

SH3 Domain Containing Ring Finger 3

(Previous name: SH3 multiple domains 4)
(Previous symbol: SH3MD4)
  Search for SH3RF3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SH3 Domain Containing Ring Finger 31 2     SH3 Multiple Domains Protein 42 3
SH3MD41 2 3     Plenty Of SH3s-22
SH3 Multiple Domains 41 2     SH3 Domain-Containing RING Finger Protein 32
Plenty Of SH3s 22 3     EC 6.3.28
POSH22 3     

External Ids:    HGNC: 246991   Entrez Gene: 3445582   Ensembl: ENSG000001729857   UniProtKB: Q8TEJ33   

Export aliases for SH3RF3 gene to outside databases

Previous GC identifers: GC02P109104 GC02P109381 GC02P109616 GC02P103343


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SH3RF3 Gene: 
SH3RF3 (SH3 domain containing ring finger 3) is a protein-coding gene. GO annotations related to this gene include zinc ion binding. An important paralog of this gene is SH3RF2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022135.16  NT_022171.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SH3RF3 gene promoter:
         Max1   HFH-3   AML1a   Egr-4   HEN1   FOXI1   FAC1   Cart-1   ZIC2/Zic2   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SH3RF3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH3RF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q13   Ensembl cytogenetic band:  2q12.3   HGNC cytogenetic band: 2q13

SH3RF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SH3RF3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P109745:  view genomic region     (about GC identifiers)

Start:
109,745,804 bp from pter      End:
110,262,207 bp from pter
Size:
516,404 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SH3R3_HUMAN, Q8TEJ3 (See protein sequence)
Recommended Name: SH3 domain-containing RING finger protein 3  
Size: 882 amino acids; 92776 Da
Subunit: Interacts with PAK2
Secondary accessions: A0SDZ7 A8MPR1 Q8NDU1

Explore the universe of human proteins at neXtProt for SH3RF3: NX_Q8TEJ3

Explore proteomics data for SH3RF3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TEJ3

  • 3 DME Specific Peptides for SH3RF3 (Q8TEJ3)
     RVDENWAEG  TGLFPGSFV  AKVLPCQHTFC 

    SH3RF3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SH3RF3 Protein Expression
    REFSEQ proteins: NP_001092759.1  
    ENSEMBL proteins: 
     ENSP00000414997   ENSP00000390685   ENSP00000309186  

    Human Recombinant Protein Products for SH3RF3: 
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    Cloud-Clone Corp. Proteins for SH3RF3 


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    Cloud-Clone Corp. ELISAs for SH3RF3 
    Cloud-Clone Corp. CLIAs for SH3RF3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    5 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR000108 p67phox
     IPR001452 SH3_domain
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q8TEJ3

    ProtoNet protein and cluster: Q8TEJ3

    UniProtKB/Swiss-Prot: SH3R3_HUMAN, Q8TEJ3
    Domain: The third SH3 domain mediates interaction with PAK2
    Similarity: Belongs to the SH3RF family
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 4 SH3 domains


    SH3RF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Enzyme Number (IUBMB): EC 6.3.22

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16374509
    GO:0008270zinc ion binding IEA--
         
    SH3RF3 for ontologies           About GeneDecksing


    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SH3RF3 
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3RF3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SH3RF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for SH3RF3 (Q8TEJ32, 3 ENSP000003091864) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAK2Q131772, 3, ENSP000003140674MINT-2792893 MINT-2792283 I2D: score=2 STRING: ENSP00000314067
    ADAM15Q134442, 3, ENSP000003494364MINT-2792701 I2D: score=2 STRING: ENSP00000349436
    RAC1P630002, 3, ENSP000003484614MINT-7987880 MINT-7987779 MINT-7987824 MINT-7987838 MINT-7987804 MINT-7987853 I2D: score=1 STRING: ENSP00000348461
    UBCP0CG482, 3, ENSP000003448184MINT-7987734 I2D: score=1 STRING: ENSP00000344818
    PDCD6IPENSP000003073874STRING: ENSP00000307387
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SH3RF3 (SH3R3)

    Search CenterWatch for drugs/clinical trials and news about SH3RF3 / SH3R3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SH3RF3 gene: 
    NM_001099289.1  

    Unigene Clusters for SH3RF3:

    SH3 domain containing ring finger 3
    Hs.171244  [show with all ESTs], Hs.535157  [show with all ESTs]
    Unigene Representative Sequences: NR_029193, NM_001099289
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418513 ENST00000444352 ENST00000309415(uc010ywt.1)
    miRNA
    Products:
         
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    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate SH3RF3 (see all 40):
    hsa-miR-579 hsa-miR-142-5p hsa-let-7d hsa-miR-548k hsa-miR-4305 hsa-miR-29a hsa-miR-192 hsa-miR-3171
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SH3RF3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SH3RF3
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    GenScript: all cDNA clones in your preferred vector: SH3RF3 (NM_001099289)
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SH3RF3
    Sirion Biotech Customized lentivirus for stable overexpression of SH3RF3 
                         Customized lentivirus expression plasmids for stable overexpression of SH3RF3 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SH3RF3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SH3RF3

    Additional mRNA sequence: 

    AK074131.1 AK093821.1 AL831825.1 

    3 DOTS entries:

    DT.314964  DT.97838784  DT.92343438 

    1 AceView cDNA sequence:

    AI214759 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SH3RF3 expression in normal human tissues (normalized intensities)      SH3RF3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCCTGTGT
    SH3RF3 Expression
    About this image


    SH3RF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             monocyte-derived macrophage   
     
     Endothelium (Cardiovascular System)
             cd31+ cells   
     
     Uterus (Reproductive System)
             endometrial endothelial cell   
     
     Eye (Sensory Organs)
             Retina
     
     Spinal Cord (Nervous System)

    See SH3RF3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SH3RF3

    SOURCE GeneReport for Unigene clusters: Hs.171244 Hs.535157
        SABiosciences Custom PCR Arrays for SH3RF3
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3RF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SH3RF3 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sh3rf31 , 5 SH3 domain containing ring finger 31, 5 82.65(n)1
    83.98(a)1
      10 (29.41 cM)5
    2373531  NM_172788.31  NP_766376.21 
     588133595 
    chicken
    (Gallus gallus)
    Aves SH3RF31 SH3 domain containing ring finger 3 74.83(n)
    77.88(a)
      418731  XM_416930.3  XP_416930.3 
    lizard
    (Anolis carolinensis)
    Reptilia SH3RF36
    SH3 domain containing ring finger 3
    62(a)
    1 ↔ 1
    3(106960072-107257547)
    zebrafish
    (Danio rerio)
    Actinopterygii SH3RF36
    SH3 domain containing ring finger 3
    46(a)
    1 ↔ 1
    9(57554305-57606825)
    fruit fly
    (Drosophila melanogaster)
    Insecta POSH1 Plenty of SH3s 45.79(n)
    37.1(a)
      36990  NM_079052.2  NP_523776.1 


    ENSEMBL Gene Tree for SH3RF3 (if available)
    TreeFam Gene Tree for SH3RF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SH3RF3 gene
    SH3RF22  SORBS32  SORBS12  SH3RF12  SORBS22  SH3D192  
    15 SIMAP similar genes for SH3RF3 using alignment to 3 protein entries:     SH3R3_HUMAN (see all proteins):
    VAV1    GRAPL    SH3GL2    ABI2    NEB    ABI1
    ARHGEF7    ABI3    RAD18    SORBS3    SH3RF1    SH3GL1
    TRIM2    SH3RF2    ITSN2

    SH3RF3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7924 SNPs in SH3RF3 are shown (see all 7924)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1885800211,2
    --109394127(+) GGCACC/TGTGGC 1 -- us2k10--------
    rs1141128271,2
    F--109394373(+) CTCTAG/TCCTGC 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs799921891,2
    C,F--109394380(+) CTGCCT/GGACAG 1 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1927790101,2
    C--109394441(+) TTATCA/TGGCAG 1 -- us2k10--------
    rs1433538951,2
    --109394458(+) TTAGAA/GGATTA 1 -- us2k10--------
    rs1470861261,2
    C--109394463(+) GGATTA/GAATAA 1 -- us2k10--------
    rs1152468651,2
    C,F--109394497(+) TAGCCT/CCAACA 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1848570311,2
    --109394568(+) CAGGCC/TGGCCG 1 -- us2k10--------
    rs749814511,2
    C,F--109394612(+) GCCCTG/TACTGA 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1883404001,2
    --109394643(+) CCAATC/GCTGGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SH3RF3 (109745804 - 109995804 bp, first 250kb of SH3RF3)

    Structural Variations
         Database of Genomic Variants (DGV) 10/20 variations for SH3RF3 (see all 20):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2720510CNV Deletion23290073
    esv2611227CNV Deletion19546169
    esv2720512CNV Deletion23290073
    esv2720511CNV Deletion23290073
    esv2720509CNV Deletion23290073
    esv2674570CNV Deletion23128226
    nsv508855CNV Insertion20534489
    nsv2873CNV Insertion18451855
    nsv508856CNV Insertion20534489
    nsv520698CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SH3RF3 for disorders           About MalaCards

    SH3RF3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SH3RF3
    Human Genome Epidemiology (HuGE) Navigator: SH3RF3 (1 document)

    Export disorders for SH3RF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SH3RF3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SH3RF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome. (PubMed id 16374509)1, 2, 3 Kaerkkaeinen S.... Saksela K. (2006)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. POSH2 is a RING finger E3 ligase with Rac1 binding ac tivity through a partial CRIB domain. (PubMed id 20696164)1 KAorkkAoinen S....Renkema G.H. (2010)
    4. Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
    5. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    9. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PubMed id 12693554)2 Jikuya H....Ohara O. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 344558 HGNC: 24699 AceView: SH3MD4 Ensembl:ENSG00000172985 euGenes: HUgn344558
    ECgene: SH3RF3 H-InvDB: SH3RF3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SH3RF3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SH3RF3 gene:
    Search GeneIP for patents involving SH3RF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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