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Aliases for SH3RF3 Gene

Aliases for SH3RF3 Gene

  • SH3 Domain Containing Ring Finger 3 2 3 5
  • SH3 Multiple Domains 4 2 3
  • SH3MD4 3 4
  • POSH2 3 4
  • SH3 Domain-Containing RING Finger Protein 3 3
  • SH3 Multiple Domains Protein 4 4
  • Plenty Of SH3s-2 3
  • Plenty Of SH3s 2 4
  • EC 6.3.2 56

External Ids for SH3RF3 Gene

Previous HGNC Symbols for SH3RF3 Gene

  • SH3MD4

Previous GeneCards Identifiers for SH3RF3 Gene

  • GC02P109381
  • GC02P109616
  • GC02P109745
  • GC02P103343

Summaries for SH3RF3 Gene

GeneCards Summary for SH3RF3 Gene

SH3RF3 (SH3 Domain Containing Ring Finger 3) is a Protein Coding gene. An important paralog of this gene is SH3RF1.

Additional gene information for SH3RF3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3RF3 Gene

Genomics for SH3RF3 Gene

GeneHancer (GH) Regulatory Elements for SH3RF3 Gene

Promoters and enhancers for SH3RF3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I109127 Promoter/Enhancer 1.4 Ensembl ENCODE 550.8 +0.1 107 3.7 ZNF2 ZNF48 GLIS2 ZNF213 ZNF143 RUNX3 REST MIER3 ZNF610 ZNF585B SH3RF3-AS1 SH3RF3 ENSG00000186148
GH02I109170 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +43.7 43749 5.1 CTCF TEAD4 TAL1 FEZF1 RAD21 FOS ZNF600 ZSCAN29 SOX6 CBFA2T3 SH3RF3-AS1 SH3RF3 PIR41817 GC02M109159
GH02I109237 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10 +110.0 110010 2.9 HDGF JUN ETV1 ZSCAN4 MAX CEBPG EBF1 POLR2A SCRT2 ETV6 SH3RF3 SH3RF3-AS1 PIR32448 SNRPGP9
GH02I109329 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.4 +202.2 202246 4.4 RAD21 ZBTB40 ZNF366 EGR1 RCOR1 ATF7 FOS IKZF2 RUNX3 EGR2 SH3RF3 GC02M109332 MIR4266 GC02P109284
GH02I109212 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.3 +84.6 84625 2.1 HDGF PKNOX1 FEZF1 ZNF2 ZNF213 ZNF207 ZNF143 SP3 JUNB REST SH3RF3 GCC2 RANBP2 PIR32448 GC02P109192
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SH3RF3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SH3RF3 gene promoter:

Genomic Locations for SH3RF3 Gene

Genomic Locations for SH3RF3 Gene
375,289 bases
Plus strand

Genomic View for SH3RF3 Gene

Genes around SH3RF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3RF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3RF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3RF3 Gene

Proteins for SH3RF3 Gene

  • Protein details for SH3RF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH3 domain-containing RING finger protein 3
    Protein Accession:
    Secondary Accessions:
    • A0SDZ7
    • A8MPR1
    • Q8NDU1

    Protein attributes for SH3RF3 Gene

    882 amino acids
    Molecular mass:
    92776 Da
    Quaternary structure:
    • Interacts with PAK2.

neXtProt entry for SH3RF3 Gene

Selected DME Specific Peptides for SH3RF3 Gene


Post-translational modifications for SH3RF3 Gene

No Post-translational modifications

Other Protein References for SH3RF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SH3RF3 Gene

Gene Families for SH3RF3 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for SH3RF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The third SH3 domain mediates interaction with PAK2.
  • Belongs to the SH3RF family.
  • The third SH3 domain mediates interaction with PAK2.
  • Belongs to the SH3RF family.
genes like me logo Genes that share domains with SH3RF3: view

Function for SH3RF3 Gene

Enzyme Numbers (IUBMB) for SH3RF3 Gene

Phenotypes From GWAS Catalog for SH3RF3 Gene

Gene Ontology (GO) - Molecular Function for SH3RF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16374509
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SH3RF3: view
genes like me logo Genes that share phenotypes with SH3RF3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH3RF3 Gene

Localization for SH3RF3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH3RF3 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Centrosome (2)
  • Cytosol (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SH3RF3 Gene

Pathways & Interactions for SH3RF3 Gene

SuperPathways for SH3RF3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SH3RF3 Gene


No data available for Pathways by source and SIGNOR curated interactions for SH3RF3 Gene

Drugs & Compounds for SH3RF3 Gene

No Compound Related Data Available

Transcripts for SH3RF3 Gene

mRNA/cDNA for SH3RF3 Gene

(60) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SH3RF3 Gene

SH3 domain containing ring finger 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3RF3 Gene

No ASD Table

Relevant External Links for SH3RF3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH3RF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SH3RF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH3RF3 Gene

This gene is overexpressed in Artery - Tibial (x4.0).

Protein differential expression in normal tissues from HIPED for SH3RF3 Gene

This gene is overexpressed in Adipocyte (32.1), Gallbladder (24.9), and Frontal cortex (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SH3RF3 Gene

Protein tissue co-expression partners for SH3RF3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SH3RF3 Gene:


SOURCE GeneReport for Unigene cluster for SH3RF3 Gene:


Evidence on tissue expression from TISSUES for SH3RF3 Gene

  • Nervous system(4.4)
  • Spleen(4.1)
genes like me logo Genes that share expression patterns with SH3RF3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SH3RF3 Gene

Orthologs for SH3RF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3RF3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SH3RF3 33 34
  • 99.53 (n)
(Canis familiaris)
Mammalia SH3RF3 33 34
  • 84.91 (n)
(Rattus norvegicus)
Mammalia Sh3rf3 33
  • 82.95 (n)
(Mus musculus)
Mammalia Sh3rf3 33 16 34
  • 82.42 (n)
(Bos Taurus)
Mammalia SH3RF3 33 34
  • 82.03 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 80 (a)
-- 34
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 13 (a)
(Gallus gallus)
Aves SH3RF3 33 34
  • 74.8 (n)
(Anolis carolinensis)
Reptilia SH3RF3 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3rf3 33
  • 67.4 (n)
(Danio rerio)
Actinopterygii SH3RF3 34
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta POSH 34
  • 32 (a)
(Caenorhabditis elegans)
Secernentea sorb-1 34
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
Species where no ortholog for SH3RF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3RF3 Gene

Gene Tree for SH3RF3 (if available)
Gene Tree for SH3RF3 (if available)

Paralogs for SH3RF3 Gene

Paralogs for SH3RF3 Gene

(15) SIMAP similar genes for SH3RF3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SH3RF3: view

Variants for SH3RF3 Gene

Sequence variations from dbSNP and Humsavar for SH3RF3 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000001447 -- 109,494,755(+) A/T genic_downstream_transcript_variant, intron_variant
rs1000011024 -- 109,185,342(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000014075 -- 109,313,734(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000021593 -- 109,458,965(+) G/A intron_variant
rs1000031159 -- 109,133,383(+) T/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SH3RF3 Gene

Variant ID Type Subtype PubMed ID
dgv1162e212 CNV gain 25503493
esv21532 CNV gain 19812545
esv24995 CNV loss 19812545
esv2611227 CNV deletion 19546169
esv2674570 CNV deletion 23128226
esv2720509 CNV deletion 23290073
esv2720510 CNV deletion 23290073
esv2720511 CNV deletion 23290073
esv2720512 CNV deletion 23290073
esv28484 CNV loss 19812545
esv3376235 CNV duplication 20981092
esv3384873 CNV insertion 20981092
esv3395490 CNV duplication 20981092
esv3559931 CNV deletion 23714750
esv3591942 CNV loss 21293372
nsv1010354 CNV gain 25217958
nsv1136394 CNV deletion 24896259
nsv1140155 CNV insertion 24896259
nsv1149522 OTHER inversion 26484159
nsv1150957 CNV deletion 26484159
nsv2873 CNV insertion 18451855
nsv474069 CNV novel sequence insertion 20440878
nsv474285 CNV novel sequence insertion 20440878
nsv475974 CNV novel sequence insertion 20440878
nsv476433 CNV novel sequence insertion 20440878
nsv476894 CNV novel sequence insertion 20440878
nsv481485 CNV novel sequence insertion 20440878
nsv508855 CNV insertion 20534489
nsv508856 CNV insertion 20534489
nsv511805 CNV loss 21212237
nsv520698 CNV loss 19592680
nsv582653 CNV loss 21841781
nsv829616 CNV loss 20364138
nsv955066 CNV deletion 24416366
nsv955092 CNV insertion 24416366
nsv963688 CNV duplication 23825009

Variation tolerance for SH3RF3 Gene

Gene Damage Index Score: 6.98; 79.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SH3RF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3RF3 Gene

Disorders for SH3RF3 Gene

Additional Disease Information for SH3RF3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SH3RF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3RF3 Gene

Publications for SH3RF3 Gene

  1. Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome. (PMID: 16374509) Kärkkäinen S … Saksela K (EMBO reports 2006) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58
  4. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens AL … Gingras AC (Science signaling 2013) 3 58
  5. POSH2 is a RING finger E3 ligase with Rac1 binding activity through a partial CRIB domain. (PMID: 20696164) Kärkkäinen S … Renkema GH (FEBS letters 2010) 3 58

Products for SH3RF3 Gene

Sources for SH3RF3 Gene

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