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Aliases for SH3RF3 Gene

Aliases for SH3RF3 Gene

  • SH3 Domain Containing Ring Finger 3 2 3
  • SH3 Multiple Domains 4 2 3
  • Plenty Of SH3s 2 3 4
  • SH3MD4 3 4
  • POSH2 3 4
  • SH3 Domain-Containing RING Finger Protein 3 3
  • SH3 Multiple Domains Protein 4 4
  • Plenty Of SH3s-2 3
  • EC 6.3.2 63

External Ids for SH3RF3 Gene

Previous HGNC Symbols for SH3RF3 Gene

  • SH3MD4

Previous GeneCards Identifiers for SH3RF3 Gene

  • GC02P109381
  • GC02P109616
  • GC02P109745
  • GC02P103343

Summaries for SH3RF3 Gene

GeneCards Summary for SH3RF3 Gene

SH3RF3 (SH3 Domain Containing Ring Finger 3) is a Protein Coding gene. An important paralog of this gene is SORBS3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3RF3 Gene

Genomics for SH3RF3 Gene

Regulatory Elements for SH3RF3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SH3RF3 Gene

109,129,348 bp from pter
109,504,632 bp from pter
375,285 bases
Plus strand

Genomic View for SH3RF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SH3RF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3RF3 Gene

Proteins for SH3RF3 Gene

  • Protein details for SH3RF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH3 domain-containing RING finger protein 3
    Protein Accession:
    Secondary Accessions:
    • A0SDZ7
    • A8MPR1
    • Q8NDU1

    Protein attributes for SH3RF3 Gene

    882 amino acids
    Molecular mass:
    92776 Da
    Quaternary structure:
    • Interacts with PAK2.

neXtProt entry for SH3RF3 Gene

Proteomics data for SH3RF3 Gene at MOPED

Selected DME Specific Peptides for SH3RF3 Gene

Post-translational modifications for SH3RF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH3RF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for SH3RF3 Gene

Gene Families for SH3RF3 Gene

Protein Domains for SH3RF3 Gene

Suggested Antigen Peptide Sequences for SH3RF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The third SH3 domain mediates interaction with PAK2
  • Belongs to the SH3RF family.
  • Contains 1 RING-type zinc finger.
  • The third SH3 domain mediates interaction with PAK2
  • Contains 4 SH3 domains.
  • Belongs to the SH3RF family.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with SH3RF3: view

Function for SH3RF3 Gene

Enzyme Numbers (IUBMB) for SH3RF3 Gene

Gene Ontology (GO) - Molecular Function for SH3RF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16374509
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with SH3RF3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SH3RF3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SH3RF3 Gene

Localization for SH3RF3 Gene

Subcellular locations from

Jensen Localization Image for SH3RF3 Gene COMPARTMENTS Subcellular localization image for SH3RF3 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SH3RF3 Gene

Transcripts for SH3RF3 Gene

mRNA/cDNA for SH3RF3 Gene

(5) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SH3RF3 Gene

SH3 domain containing ring finger 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SH3RF3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3RF3 Gene

No ASD Table

Relevant External Links for SH3RF3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH3RF3 Gene

mRNA expression in normal human tissues for SH3RF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH3RF3 Gene

This gene is overexpressed in Artery - Tibial (4.0).

Protein differential expression in normal tissues for SH3RF3 Gene

This gene is overexpressed in Adipocyte (32.1), Gallbladder (24.9), and Frontal cortex (11.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SH3RF3 Gene

SOURCE GeneReport for Unigene cluster for SH3RF3 Gene Hs.171244

genes like me logo Genes that share expressions with SH3RF3: view

Expression partners for SH3RF3 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SH3RF3 Gene

Orthologs for SH3RF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3RF3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SH3RF3 35
  • 82.03 (n)
  • 79.5 (a)
SH3RF3 36
  • 80 (a)
(Canis familiaris)
Mammalia SH3RF3 35
  • 84.91 (n)
  • 85.1 (a)
SH3RF3 36
  • 86 (a)
(Mus musculus)
Mammalia Sh3rf3 35
  • 82.42 (n)
  • 83.3 (a)
Sh3rf3 16
Sh3rf3 36
  • 83 (a)
(Pan troglodytes)
Mammalia SH3RF3 35
  • 99.53 (n)
  • 99.06 (a)
SH3RF3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Sh3rf3 35
  • 82.95 (n)
  • 83.96 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 80 (a)
-- 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 13 (a)
(Gallus gallus)
Aves SH3RF3 35
  • 74.8 (n)
  • 76.78 (a)
SH3RF3 36
  • 68 (a)
(Anolis carolinensis)
Reptilia SH3RF3 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3rf3 35
  • 67.4 (n)
  • 72.01 (a)
(Danio rerio)
Actinopterygii SH3RF3 36
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta POSH 36
  • 32 (a)
(Caenorhabditis elegans)
Secernentea sorb-1 36
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
Species with no ortholog for SH3RF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3RF3 Gene

Gene Tree for SH3RF3 (if available)
Gene Tree for SH3RF3 (if available)

Paralogs for SH3RF3 Gene

Paralogs for SH3RF3 Gene

(15) SIMAP similar genes for SH3RF3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SH3RF3: view

Variants for SH3RF3 Gene

Sequence variations from dbSNP and Humsavar for SH3RF3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs718182 -- 109,336,001(+) GGCTG(A/G)TTTAA intron-variant
rs720978 -- 109,335,475(-) CTAGT(C/G)GACGA intron-variant
rs720979 -- 109,335,254(-) GGGAC(A/G)GGCGA intron-variant
rs730491 -- 109,284,557(-) CACAT(A/C)ATTCA intron-variant
rs732476 -- 109,326,069(-) CATAC(A/G)CCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH3RF3 Gene

Variant ID Type Subtype PubMed ID
nsv874773 CNV Gain 21882294
nsv874774 CNV Gain 21882294
esv21532 CNV Gain 19812545
esv2720509 CNV Deletion 23290073
esv2674570 CNV Deletion 23128226
esv2720510 CNV Deletion 23290073
esv2720511 CNV Deletion 23290073
nsv874776 CNV Gain 21882294
nsv511805 CNV Loss 21212237
esv2611227 CNV Deletion 19546169
esv2720512 CNV Deletion 23290073
nsv874777 CNV Gain 21882294
nsv508855 CNV Insertion 20534489
nsv874778 CNV Loss 21882294
esv28484 CNV Loss 19812545
nsv829616 CNV Loss 20364138
nsv520698 CNV Loss 19592680
nsv508856 CNV Insertion 20534489
esv24995 CNV Loss 19812545
nsv2873 CNV Insertion 18451855

Relevant External Links for SH3RF3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3RF3 Gene

Disorders for SH3RF3 Gene

Relevant External Links for SH3RF3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for SH3RF3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SH3RF3 Gene

Publications for SH3RF3 Gene

  1. Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome. (PMID: 16374509) Kaerkkaeinen S. … Saksela K. (EMBO Rep. 2006) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. POSH2 is a RING finger E3 ligase with Rac1 binding activity through a partial CRIB domain. (PMID: 20696164) KAorkkAoinen S. … Renkema G.H. (FEBS Lett. 2010) 3
  4. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 3
  5. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PMID: 12693554) Jikuya H. … Ohara O. (DNA Res. 2003) 4

Products for SH3RF3 Gene

Sources for SH3RF3 Gene

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