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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SH3RF3 Gene

protein-coding GIFtS: 43
GCID: GC02P109745

SH3 domain containing ring finger 3

(Previous name: SH3 multiple domains 4 )
(Previous symbol: SH3MD4)

Search for SH3RF3
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
SH3 Domain Containing Ring Finger 3¹ ²		SH3 Multiple Domains Protein 4² ³
POSH2¹ ² ³		FLJ00204¹
SH3MD4¹ ² ³		Plenty Of SH3s-2²
SH3 Multiple Domains 4¹ ²		SH3 Domain-Containing RING Finger Protein 3²
Plenty Of SH3s 2² ³		EC 6.3.2⁸

External Ids:	HGNC: 24699¹	Entrez Gene: 344558²	Ensembl: ENSG00000172985⁷	UniProtKB: Q8TEJ3³

Export aliases for SH3RF3 gene to outside databases

Previous GC identifers: GC02P109104 GC02P109381 GC02P109616 GC02P103343

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022135.16 NT_022171.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SH3RF3 gene promoter:
Max1 HFH-3 AML1a Egr-4 HEN1 FOXI1 FAC1 Cart-1 ZIC2/Zic2 c-Myc
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for SH3RF3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH3RF3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q13 Ensembl cytogenetic band: 2q12.3 HGNC cytogenetic band: 2q13

SH3RF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SH3RF3 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P109745: view genomic region (about GC identifiers)

Start:	109,745,804 bp from pter	End:	110,262,207 bp from pter
Size:	516,404 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SH3R3_HUMAN, Q8TEJ3 (See protein sequence)

Recommended Name: SH3 domain-containing RING finger protein 3

Size: 882 amino acids; 92776 Da

Subunit: Interacts with PAK2

Secondary accessions: A0SDZ7 A8MPR1 Q8NDU1

Explore the universe of human proteins at neXtProt for SH3RF3: NX_Q8TEJ3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8TEJ3

3 DME Specific Peptides for SH3RF3 (Q8TEJ3)

RVDENWAEG

TGLFPGSFV

AKVLPCQHTFC

SH3RF3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001092759.1

ENSEMBL proteins:

ENSP00000414997 ENSP00000390685 ENSP00000309186

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SH3RF3 for domains About GeneDecksing

5 InterPro domains/families:

IPR017907 Znf_RING_CS

IPR001841 Znf_RING

IPR000108 p67phox

IPR001452 SH3_domain

IPR013083 Znf_RING/FYVE/PHD

Graphical View of Domain Structure for InterPro Entry Q8TEJ3

ProtoNet protein and cluster: Q8TEJ3

UniProtKB/Swiss-Prot: SH3R3_HUMAN, Q8TEJ3

Domain: The third SH3 domain mediates interaction with PAK2

Similarity: Belongs to the SH3RF family

Similarity: Contains 1 RING-type zinc finger

Similarity: Contains 4 SH3 domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Enzyme Number (IUBMB): EC 6.3.2²

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3RF3

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008270	zinc ion binding	IEA	--

SH3RF3 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SH3RF3

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/6 Interacting proteins for SH3RF3 (Q8TEJ3^{2, 3} ENSP00000309186⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PAK2	Q13177²^,³, ENSP00000314067⁴	MINT-2792893 MINT-2792283 I2D: score=2 STRING: ENSP00000314067
ADAM15	Q13444²^,³, ENSP00000349436⁴	MINT-2792701 I2D: score=2 STRING: ENSP00000349436
RAC1	P63000²^,³, ENSP00000348461⁴	MINT-7987880 MINT-7987779 MINT-7987824 MINT-7987838 MINT-7987804 MINT-7987853 I2D: score=1 STRING: ENSP00000348461
UBC	P0CG48²^,³, ENSP00000344818⁴	MINT-7987734 I2D: score=1 STRING: ENSP00000344818
PDCD6IP	ENSP00000307387⁴	STRING: ENSP00000307387

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SH3RF3
Search CenterWatch for drugs/clinical trials and news about SH3RF3 / SH3R3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SH3RF3 gene:

NM_001099289.1

Unigene Clusters for SH3RF3:

SH3 domain containing ring finger 3

Hs.171244 [show with all ESTs], Hs.535157 [show with all ESTs]

Unigene Representative Sequences: NR_029193, NM_001099289

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000418513 ENST00000444352 ENST00000309415(uc010ywt.1)

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		hsa-miR-579 hsa-miR-142-5p hsa-let-7d hsa-miR-548k hsa-miR-4305 hsa-miR-29a hsa-miR-192 hsa-miR-3171

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Additional cDNA sequence:

AK074131.1 AK093821.1 AL831825.1

3 DOTS entries:

DT.314964 DT.97838784 DT.92343438

1 AceView cDNA sequence:

AI214759

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SH3RF3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGCCTGTGT

About this image

SH3RF3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Spinal Neural Tube Cells

Neural Ectoderm

Eye

Retina

Eye

Spinal Cord

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SH3RF3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SH3RF3

SOURCE GeneReport for Unigene clusters: Hs.171244 Hs.535157

SABiosciences Custom PCR Arrays for SH3RF3

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SH3RF3 gene from 4/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SH3RF3¹	SH3 domain containing ring finger 3	74.83(n) 77.88(a)		418731 XM_416930.3 XP_416930.3
lizard (Anolis carolinensis)	Reptilia	SH3RF3⁶	--	62(a)	1 ↔ 1	3(106965205-107068171)
zebrafish (Danio rerio)	Actinopterygii	si:ch211-124n19.2⁶ CU179640.1⁶	--	45(a) 29(a)	1 ↔ 1 possible ortholog	9(57554305-57606825) 14(24833336-24862179)
fruit fly (Drosophila melanogaster)	Insecta	POSH¹	Plenty of SH3s	45.79(n) 37.1(a)		36990 NM_079052.2 NP_523776.1

ENSEMBL Gene Tree for SH3RF3 (if available)
TreeFam Gene Tree for SH3RF3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SH3RF3 gene

SH3RF2² SORBS3² SH3RF1² SORBS1² SORBS2² SH3D19²

16 SIMAP similar genes for SH3RF3 using alignment to 3 protein entries: SH3R3_HUMAN (see all proteins):

NOSTRIN VAV1 GRAPL SH3GL2 ABI2 NEB

ABI1 ARHGEF7 ABI3 RAD18 SORBS3 SH3RF1

SH3GL1 TRIM2 SH3RF2 ITSN2

SH3RF3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs13402256^1,2	C,F,H,	--	103557805(+)	`CATTTC/TCTGAT`	1	--	ds500¹		17	NS EA NA WA CSA	2222
rs73955548^1,2	C,F,	--	103557928(+)	`TCATTC/TCCCCT`	1	--	ds500¹		3	WA CSA	122
rs72939589^1,2	C,	--	103558209(+)	`GTACAA/GTCTCC`	1	--	ds500¹		2	WA	120
rs79382823^1,2	C,	--	103558392(+)	`GAGACT/GACAGG`	1	--	nc-transcript-variant		3	WA CSA	121
rs79552535^1,2	C,F,	--	103558532(+)	`AATAGG/TCGTGA`	1	--	nc-transcript-variant		3	WA CSA	122
rs12470895^1,2	C,F,H,	--	103558649(+)	`GAGGGG/TACCTG`	1	--	nc-transcript-variant		15	NS NA CSA WA	1884
rs6731363^1,2	C,F,A,H,	--	103558688(+)	`NNNNTC/AATCAG`	1	--	nc-transcript-variant		20	NS EA NA CSA WA	2322
rs77095135^1,2	F,	--	103558829(+)	`GTGACG/AGGGGA`	1	--	nc-transcript-variant		1	NA	120
rs73955549^1,2	C,F,	--	103559004(+)	`GCTGCC/TGTGCC`	1	--	nc-transcript-variant		3	WA CSA	122
rs112999187^1,2	C,F,	--	103559010(+)	`GTGCCG/AAGGAG`	1	--	nc-transcript-variant		2	CSA WA	122

HapMap Linkage Disequilibrium report for SH3RF3 (109745804 - 109995804 bp, first 250kb of SH3RF3)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for SH3RF3
3 CNVs: 97935 74194 74195
2 Indels: 74193 68116

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SH3RF3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SH3RF3 for disorders About MalaCards

SH3RF3 for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: SH3RF3 (1 document)

Export disorders for SH3RF3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SH3RF3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SH3RF3)

Utopia: connect your pdf to the dynamic
world of online information

Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome. (PubMed id 16374509)^{1, 2, 3} Kaerkkaeinen S.... Saksela K. (2006)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
POSH2 is a RING finger E3 ligase with Rac1 binding ac tivity through a partial CRIB domain. (PubMed id 20696164)¹ KAorkkAoinen S....Renkema G.H. (2010)
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)² Cantin G.T....Yates J.R. III (2008)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PubMed id 12693554)² Jikuya H....Ohara O. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 344558	HGNC: 24699	AceView: SH3MD4	Ensembl:ENSG00000172985	euGenes: HUgn344558
ECgene: SH3RF3	H-InvDB: SH3RF3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SH3RF3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SH3RF3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SH3RF3 gene:
Search GeneIP for patents involving SH3RF3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SH3RF3		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SH3RF3
	OriGene Protein Over-expression Lysate for SH3RF3		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SH3RF3		OriGene 3'-UTR Clone for SH3RF3
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH3RF3		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH3RF3
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SH3RF3
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	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SH3RF3
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SH3RF3
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	GenScript Custom Purified and Recombinant Proteins Services for SH3RF3		GenScript cDNA clones with any tag delivered in your preferred vector for SH3RF3
	GenScript Custom Assay Services for SH3RF3		GenScript Custom Superior Antibodies Services for SH3RF3
	GenScript Custom overexpressing Cell Line Services for SH3RF3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SH3RF3 gene at Home site.

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SH3RF3 Gene

SH3 domain containing ring finger 3

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SH3RF3 Gene

SH3 domain containing ring finger 3

Aliasesfor SH3RF3 gene

Summariesfor SH3RF3 gene

Genomic Viewsfor SH3RF3 gene

Proteinsfor SH3RF3 gene

Protein Domains /Familiesfor SH3RF3 gene

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for SH3RF3 gene

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for SH3RF3 gene

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for SH3RF3 gene

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