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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SH3RF2 Gene

protein-coding GIFtS: 50
GCID: GC05P145296

SH3 domain containing ring finger 2

(Previous names: protein phosphatase 1, regulatory subunit 39 )
(Previous symbol: PPP1R39)

Search for SH3RF2
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
SH3 Domain Containing Ring Finger 2¹ ²		RING Finger Protein 158² ³
PPP1R39¹ ² ³		SH3 Domain-Containing RING Finger Protein 2² ³
RNF158¹ ² ³		FLJ23654¹
HEPP1² ³ ⁵		Hepp1¹
POSHER¹ ²		POSH-Eliminating RING Protein²
Protein Phosphatase 1, Regulatory Subunit 39¹ ²		Putative E3 Ubiquitin-Protein Ligase SH3RF2²
Heart Protein Phosphatase 1-Binding Protein² ³		EC 6.3.2.-³
Protein Phosphatase 1 Regulatory Subunit 39² ³		EC 6.3.2⁸

External Ids:	HGNC: 26299¹	Entrez Gene: 153769²	Ensembl: ENSG00000156463⁷	OMIM: 613377⁵	UniProtKB: Q8TEC5³

Export aliases for SH3RF2 gene to outside databases

Previous GC identifers: GC05P145345 GC05P140462

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SH3R2_HUMAN, Q8TEC5

Function: Inhibits PPP1CA phosphatase activity. May be a E3 ubiquitin-protein ligase (Potential). May play a role in

cardiac function

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_029289.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SH3RF2 gene promoter:
AML1a Lmo2 POU6F1 (c2) Tal-1beta Cdc5 Gfi-1 E47 Arnt HSF2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SH3RF2 promoter sequence

Search SABiosciences Chromatin IP Primers for SH3RF2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH3RF2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32 Ensembl cytogenetic band: 5q32 HGNC cytogenetic band: 5q32

SH3RF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SH3RF2 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P145296: view genomic region (about GC identifiers)

Start:	145,316,126 bp from pter	End:	145,461,354 bp from pter
Size:	145,229 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SH3R2_HUMAN, Q8TEC5 (See protein sequence)

Recommended Name: Putative E3 ubiquitin-protein ligase SH3RF2

Size: 729 amino acids; 79320 Da

Subunit: Interacts with FASLG and PPP1CA

Sequence caution: Sequence=AAH31650.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Sequence=BAB85025.1; Type=Erroneous termination; Positions=458; Note=Translated as Trp;

Secondary accessions: A8K961 Q08AM9 Q6GMR9 Q8N5S8 Q96LP8

Alternative splicing: 3 isoforms: Q8TEC5-1 Q8TEC5-2 Q8TEC5-3

Explore the universe of human proteins at neXtProt for SH3RF2: NX_Q8TEC5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8TEC5

4/5 DME Specific Peptides for SH3RF2 (Q8TEC5) (see all 5)

LLECPVC

HTFCKPC

RVDENWAEG

PVLISSSNP

SH3RF2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_689763.3

ENSEMBL proteins:

ENSP00000352028 ENSP00000424497

Human Recombinant Protein Products for SH3RF2:

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	Uscn Proteins for SH3RF2

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	Uscn ELISAs and CLIAs for SH3RF2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SH3RF2 for domains About GeneDecksing

5 InterPro domains/families:

IPR011511 SH3_2

IPR017907 Znf_RING_CS

IPR001841 Znf_RING

IPR001452 SH3_domain

IPR013083 Znf_RING/FYVE/PHD

Graphical View of Domain Structure for InterPro Entry Q8TEC5

ProtoNet protein and cluster: Q8TEC5

3 Blocks protein families:

IPB001452 SH3 domain signature

IPB001841 Zn-finger

IPB011511 Variant SH3

UniProtKB/Swiss-Prot: SH3R2_HUMAN, Q8TEC5

Domain: The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity)

Similarity: Belongs to the SH3RF family

Similarity: Contains 1 RING-type zinc finger

Similarity: Contains 3 SH3 domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SH3R2_HUMAN, Q8TEC5

Function: Inhibits PPP1CA phosphatase activity. May be a E3 ubiquitin-protein ligase (Potential). May play a role in

cardiac function

Enzyme Numbers (IUBMB): EC 6.3.2.-¹ EC 6.3.2²

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004864	protein phosphatase inhibitor activity	IEA	--
GO:0005515	protein binding	IPI	--
GO:0008157	protein phosphatase 1 binding	IDA	19945436
GO:0008270	zinc ion binding	IEA	--
GO:0016874	ligase activity	IEA	--

SH3RF2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for SH3RF2:

Increased HPV18 LCR reporter a

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SH3RF2

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SH3RF2
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate SH3RF2:
		hsa-miR-4254 hsa-miR-1197 hsa-miR-186* hsa-miR-1827 hsa-miR-650 hsa-miR-3612 hsa-miR-4287
		SwitchGear 3'UTR luciferase reporter plasmid: SH3RF2 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3RF2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

UniProtKB/Swiss-Prot: SH3R2_HUMAN, Q8TEC5

Pathway: Protein modification; protein ubiquitination

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SH3RF2

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/6 Interacting proteins for SH3RF2 (Q8TEC5^{1, 3} ENSP00000352028⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBE2N	P61088³, ENSP00000316176⁴	I2D: score=2 STRING: ENSP00000316176
FASLG	P48023³, ENSP00000356694⁴	I2D: score=1 STRING: ENSP00000356694
PPP1CA	P62136¹, ENSP00000326031⁴	EBI-2130111,EBI-2623163 STRING: ENSP00000326031
RAC1	ENSP00000348461⁴	STRING: ENSP00000348461
SH3RF1	ENSP00000284637⁴	STRING: ENSP00000284637

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0010923	negative regulation of phosphatase activity	IDA	19389623
GO:0016567	protein ubiquitination	IEA	--

SH3RF2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SH3RF2
Search CenterWatch for drugs/clinical trials and news about SH3RF2 / SH3R2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SH3RF2 gene:

NM_152550.3

Unigene Cluster for SH3RF2:

SH3 domain containing ring finger 2

Hs.443728 [show with all ESTs]

Unigene Representative Sequence: AL833297

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000359120(uc003lnt.3 uc003lnu.3 uc011dbo.2) ENST00000506591

ENST00000511217(uc011dbl.1) ENST00000509286 ENST00000503848 ENST00000511705(uc011dbm.1 uc011dbn.1)

ENST00000504522

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SH3RF2
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate SH3RF2:
		hsa-miR-4254 hsa-miR-1197 hsa-miR-186* hsa-miR-1827 hsa-miR-650 hsa-miR-3612 hsa-miR-4287
		SwitchGear 3'UTR luciferase reporter plasmid: SH3RF2 3' UTR sequence

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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SH3RF2
		Sirion Biotech Custom design and validation of potent shRNA sequences against SH3RF2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH3RF2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH3RF2 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SH3RF2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SH3RF2

Additional cDNA sequence:

AK058046.1 AK074234.1 AK292576.1 AK302024.1 AL833297.1 BC031650.2 BC073914.1 BC125106.1

BC125107.1 FJ695509.1

9 DOTS entries:

DT.100748727 DT.426685 DT.75117112 DT.40308969 DT.70100442 DT.120873814 DT.86853952 DT.432448

DT.95146306

24/104 AceView cDNA sequences (see all 104):

BX112760 BE042751 BX283463 AI935909 AA954419 BF332478 AI286348 NM_152550

AW009429 BG680580 AW452250 AW473297 CA448483 BI519965 BF754847 BQ931816

AI219544 BU147229 BI827187 BI520050 AA577489 AK074234 AI863457 BQ930446

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for SH3RF2 About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c	·	8d	^	9a	·	9b	^	10a	·	10b	·	10c	^	11a	·	11b
SP1:																	-		-		-		-				-
SP2:
SP3:																							-
SP4:																											-
SP5:

ECgene alternative splicing isoforms for SH3RF2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SH3RF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTATTTTCA

About this image

SH3RF2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Dorsal Columns

Dorsal Spinal Cord Progenitor Cells

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Neural Tube

Neural Tube

Spinal Dorsal Columns

Spinal Cord

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

See SH3RF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SH3RF2

SOURCE GeneReport for Unigene cluster: Hs.443728

UniProtKB/Swiss-Prot: SH3R2_HUMAN, Q8TEC5

Tissue specificity: Heart (at protein level). Heart and testis. In the heart, present in the apex, left atrium, right

atrium, left ventricle and right ventricle, but not in the aorta

SABiosciences Custom PCR Arrays for SH3RF2

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SH3RF2 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sh3rf2^{1 , 5}	SH3 domain containing ring finger 2^{1, 5}	84.16(n)¹ 81.87(a)¹		18 (22.21 cM)⁵ 269016¹ NM_001146299.1¹ NP_001139771.1¹ 42053667⁵
chicken (Gallus gallus)	Aves	SH3RF2¹	SH3 domain containing ring finger 2	61.65(n) 58.68(a)		416346 XM_414662.3 XP_414662.3
lizard (Anolis carolinensis)	Reptilia	PPP1R39⁶	--	47(a)	1 ↔ 1	GL343234.1(756947-858643)
zebrafish (Danio rerio)	Actinopterygii	CU179640.1⁶	--	27(a)	possible ortholog	14(24833336-24862179)
fruit fly (Drosophila melanogaster)	Insecta	POSH⁶	Plenty of SH3s	19(a)	1 → many	2R(13456232-13459827)

ENSEMBL Gene Tree for SH3RF2 (if available)
TreeFam Gene Tree for SH3RF2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SH3RF2 gene

SH3RF3² SORBS3² SH3RF1² SORBS1² SORBS2² SH3D19²

5 SIMAP similar genes for SH3RF2 using alignment to 2 protein entries: SH3R2_HUMAN (see all proteins):

SH3GL2 ARHGEF7 SH3GL1 SH3RF3 SH3RF1

SH3RF2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150651952^1,2		--	145314177(+)	`GTCCTA/GCATCA`	1	--	us2k¹		0	--	--	--	--
rs143000561^1,2		--	145314296(+)	`ATATGC/TAAACA`	1	--	us2k¹		0	--	--	--	--
rs192952313^1,2		--	145314304(+)	`ACAATA/GTTTTC`	1	--	us2k¹		0	--	--	--	--
rs185154881^1,2		--	145314389(+)	`ATCCTC/TACGTC`	1	--	us2k¹		0	--	--	--	--
rs34484886^1,2	C	--	145314453(+)	`CTCTT-/ATTTTT`	1	--	us2k¹		1		NA	2
rs76292079^1,2	C	--	145314454(+)	`CTCTTT/ATTTTT`	1	--	us2k¹		1		WA	2
rs190531192^1,2		--	145314477(+)	`TGAGAC/TGGAGT`	1	--	us2k¹		0	--	--	--	--
rs111491569^1,2	C	--	145314489(+)	`TTAGTC/TGCCCA`	1	--	us2k¹		1		WA	2
rs6894264^1,2	C,F,A,H	--	145314730(+)	`TCACCG/ACGCCT`	1	--	us2k¹		7		NA WA CSA EA	366
rs185502259^1,2		--	145314761(+)	`TAGTCC/TCAATT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SH3RF2 (145316126 - 145461354 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SH3RF2
2 CNVs: 81066 39435

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SH3RF2

DNA2.0 Custom Variant and Variant Library Synthesis for SH3RF2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SH3RF2 for disorders About MalaCards

SH3RF2 for disorders About GeneDecksing

OMIM gene information: 613377 OMIM disorders: --

Human Genome Epidemiology (HuGE) Navigator: SH3RF2 (1 document)

Export disorders for SH3RF2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SH3RF2 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with SH3RF2)

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Sh3rf2/POSHER protein promotes cell survival by ring-m ediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Pl enty of SH3s) protein. (PubMed id 22128169)^{1, 3} Wilhelm M....Greene L.A. (2012)
FLJ23654 encodes a heart protein phosphatase 1-binding protein (Hepp1). (PubMed id 19945436)^{1, 2} Chen C.Y.... Huang H.B. (2010)
Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)^{1, 2} Voss M....Janssen O. (2009)
Docking motif-guided mapping of the interactome of protein phosphatase-1. (PubMed id 19389623)^{1, 2} Hendrickx A.... Bollen M. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Protein phosphatase 1a interacting proteins in the hum an brain. (PubMed id 22321011)¹ Esteves S.L....da Cruz e Silva E.F. (2012)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)¹ Bennett E.J....Harper J.W. (2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 153769	HGNC: 26299	AceView: SH3RF2	Ensembl:ENSG00000156463	euGenes: HUgn153769
ECgene: SH3RF2	H-InvDB: SH3RF2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SH3RF2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SH3RF2 gene
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Patent Information for SH3RF2 gene:
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SH3RF2 Gene

SH3 domain containing ring finger 2

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SH3 domain containing ring finger 2

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