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SH3RF2 Gene

protein-coding   GIFtS: 51
GCID: GC05P145296

SH3 Domain Containing Ring Finger 2

(Previous names: protein phosphatase 1, regulatory subunit 39)
(Previous symbol: PPP1R39)
  Search for SH3RF2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SH3 Domain Containing Ring Finger 21 2     RNF1582 3
PPP1R391 2 3     RING Finger Protein 1582 3
Heart Protein Phosphatase 1-Binding Protein1 2 3     SH3 Domain-Containing RING Finger Protein 22 3
HEPP12 3 5     POSHER2
Protein Phosphatase 1, Regulatory Subunit 391 2     Putative E3 Ubiquitin-Protein Ligase SH3RF22
POSH-Eliminating RING Protein1 2     EC 6.3.2.-3
Protein Phosphatase 1 Regulatory Subunit 392 3     EC 6.3.28

External Ids:    HGNC: 262991   Entrez Gene: 1537692   Ensembl: ENSG000001564637   OMIM: 6133775   UniProtKB: Q8TEC53   

Export aliases for SH3RF2 gene to outside databases

Previous GC identifers: GC05P145345 GC05P140462


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SH3RF2 Gene:
SH3RF2 (SH3 domain containing ring finger 2) is a protein-coding gene. GO annotations related to this gene include protein phosphatase inhibitor activity and ligase activity. An important paralog of this gene is SH3RF3.

UniProtKB/Swiss-Prot: SH3R2_HUMAN, Q8TEC5
Function: Inhibits PPP1CA phosphatase activity. May be a E3 ubiquitin-protein ligase (Potential). May play a role
in cardiac function




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_029289.12  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SH3RF2 gene promoter:
         AML1a   Lmo2   POU6F1 (c2)   Tal-1beta   Cdc5   Gfi-1   E47   Arnt   HSF2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSH3RF2 promoter sequence
   Search Chromatin IP Primers for SH3RF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SH3RF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q32

SH3RF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SH3RF2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P145296:  view genomic region     (about GC identifiers)

Start:
145,316,126 bp from pter      End:
145,461,354 bp from pter
Size:
145,229 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SH3R2_HUMAN, Q8TEC5 (See protein sequence)
Recommended Name: Putative E3 ubiquitin-protein ligase SH3RF2  
Size: 729 amino acids; 79320 Da
Subunit: Interacts with FASLG and PPP1CA
Sequence caution: Sequence=AAH31650.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB85025.1; Type=Erroneous termination; Positions=458; Note=Translated as Trp;
Secondary accessions: A8K961 Q08AM9 Q6GMR9 Q8N5S8 Q96LP8
Alternative splicing: 3 isoforms:  Q8TEC5-1   Q8TEC5-2   Q8TEC5-3   

Explore the universe of human proteins at neXtProt for SH3RF2: NX_Q8TEC5

Explore proteomics data for SH3RF2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SH3RF2 (Q8TEC5) (see all 5)
     LLECPVC  HTFCKPC  RVDENWAEG  PVLISSSNP 


    See SH3RF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689763.3  
    ENSEMBL proteins: 
     ENSP00000352028   ENSP00000424497  

    SH3RF2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 6):
     IPR001841 Znf_RING
     IPR001452 SH3_domain
     IPR013083 Znf_RING/FYVE/PHD
     IPR011511 SH3_2
     IPR017907 Znf_RING_CS

    Graphical View of Domain Structure for InterPro Entry Q8TEC5

    ProtoNet protein and cluster: Q8TEC5

    3 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB001841 Zn-finger
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: SH3R2_HUMAN, Q8TEC5
    Domain: The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity)
    Similarity: Belongs to the SH3RF family
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 3 SH3 domains


    Find genes that share domains with SH3RF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SH3R2_HUMAN, Q8TEC5
    Function: Inhibits PPP1CA phosphatase activity. May be a E3 ubiquitin-protein ligase (Potential). May play a role
    in cardiac function

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004864protein phosphatase inhibitor activity IEA--
    GO:0005515protein binding IPI19389623
    GO:0008157protein phosphatase 1 binding IDA19945436
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
         
    Find genes that share ontologies with SH3RF2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SH3RF2:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SH3RF2
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    hsa-miR-4254 hsa-miR-1197 hsa-miR-186* hsa-miR-1827 hsa-miR-650 hsa-miR-3612 hsa-miR-4287
    SwitchGear 3'UTR luciferase reporter plasmidSH3RF2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SH3RF2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: SH3R2_HUMAN, Q8TEC5
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SH3RF2
    Interactions:

        Search GeneGlobe Interaction Network for SH3RF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SH3RF2 (Q8TEC51, 3 ENSP000003520284) via UniProtKB, MINT, STRING, and/or I2D (see all 30)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2NP610883, ENSP000003161764I2D: score=2 STRING: ENSP00000316176
    FASLGP480233, ENSP000003566944I2D: score=1 STRING: ENSP00000356694
    PPP1CAP621361, ENSP000003260314EBI-2130111,EBI-357253 STRING: ENSP00000326031
    RAC1ENSP000003484614STRING: ENSP00000348461
    SH3RF1ENSP000002846374STRING: ENSP00000284637
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010923negative regulation of phosphatase activity IDA19389623
    GO:0016567protein ubiquitination IEA--

    Find genes that share ontologies with SH3RF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SH3RF2 (SH3R2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SH3RF2 gene: 
    NM_152550.3  

    Unigene Cluster for SH3RF2:

    SH3 domain containing ring finger 2
    Hs.443728  [show with all ESTs]
    Unigene Representative Sequence: AL833297
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359120(uc003lnt.3 uc003lnu.3 uc011dbo.2) ENST00000506591
    ENST00000511217(uc011dbl.1) ENST00000509286 ENST00000503848 ENST00000511705(uc011dbm.1 uc011dbn.1)
    ENST00000504522
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate SH3RF2:
    hsa-miR-4254 hsa-miR-1197 hsa-miR-186* hsa-miR-1827 hsa-miR-650 hsa-miR-3612 hsa-miR-4287
    SwitchGear 3'UTR luciferase reporter plasmidSH3RF2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SH3RF2
      QuantiFast Probe-based Assays in human, mouse, rat SH3RF2

    Additional mRNA sequence: 

    AK058046.1 AK074234.1 AK292576.1 AK302024.1 AL833297.1 BC031650.2 BC073914.1 BC125106.1 
    BC125107.1 FJ695509.1 

    9 DOTS entries:

    DT.100748727  DT.426685  DT.75117112  DT.40308969  DT.70100442  DT.120873814  DT.86853952  DT.432448 
    DT.95146306 

    Selected AceView cDNA sequences (see all 104):

    AA954419 BE042751 BG680580 BF332478 AW009429 CA448483 AW473297 BX283463 
    AI935909 NM_152550 AI286348 BX112760 AW452250 AW341531 AW207397 AI219544 
    BQ930446 BI827373 CB123904 H53759 BC073914 BI830329 BE615992 BG678030 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SH3RF2    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b
    SP1:                                                  -     -     -     -           -                                 
    SP2:                                                                                                                  
    SP3:                                                                    -                                             
    SP4:                                                                                -                                 
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for SH3RF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SH3RF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTATTTTCA
    SH3RF2 Expression
    About this image


    SH3RF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     NULL (Uncategorized)
             DKK1-induced cells
     
     Brain (Nervous System)
             Striatum
     
     Testis (Reproductive System)
    SH3RF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SH3RF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.443728

    UniProtKB/Swiss-Prot: SH3R2_HUMAN, Q8TEC5
    Tissue specificity: Heart (at protein level). Heart and testis. In the heart, present in the apex, left atrium,
    right atrium, left ventricle and right ventricle, but not in the aorta

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SH3RF2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sh3rf21 , 5 SH3 domain containing ring finger 21, 5 83.98(n)1
    81.62(a)1
      18 (22.21 cM)5
    2690161  NM_001146299.11  NP_001139771.11 
     420536675 
    chicken
    (Gallus gallus)
    Aves SH3RF21 SH3 domain containing ring finger 2 61.4(n)
    57.65(a)
      416346  XM_414662.4  XP_414662.3 
    lizard
    (Anolis carolinensis)
    Reptilia SH3RF26
    SH3 domain containing ring finger 2
    55(a)
    1 ↔ 1
    GL343234.1(755793-860057)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sh3rf21 SH3 domain containing ring finger 2 56.77(n)
    50.32(a)
      100497897  XM_002935265.2  XP_002935311.1 
    zebrafish
    (Danio rerio)
    Actinopterygii SH3RF26
    SH3 domain containing ring finger 2
    33(a)
    1 ↔ 1
    14(24833336-24862179) ENSDARG00000086954
    fruit fly
    (Drosophila melanogaster)
    Insecta POSH6
    Plenty of SH3s
    23(a)
    1 → many
    2R(13456232-13459827)
    worm
    (Caenorhabditis elegans)
    Secernentea sorb-16
    Protein SORB-1, isoform a (sorb-1) mRNA, complete ...
    10(a)
    1 → many
    IV(13750336-13770607) WBGene00012891


    ENSEMBL Gene Tree for SH3RF2 (if available)
    TreeFam Gene Tree for SH3RF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SH3RF2 gene
    SH3RF32  SORBS32  SORBS12  SH3RF12  SORBS22  SH3D192  
    5 SIMAP similar genes for SH3RF2 using alignment to 2 protein entries:     SH3R2_HUMAN (see all proteins):
    SH3GL2    ARHGEF7    SH3GL1    SH3RF3    SH3RF1

    Find genes that share paralogs with SH3RF2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SH3RF2 (see all 2668)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1390011551,2
    Cuntested1145439782(+) GCATCA/GAAAAG 2 K E mis10--------
    rs357653491,2
    --140489699(+) TGGATG/TAATAA 1 -- int10--------
    rs610465321,2
    C--140522956(+) TCTCT-/GACT  
            
    AATTG
    1 -- int10--------
    rs1506519521,2
    --145314177(+) GTCCTA/GCATCA 1 -- us2k10--------
    rs1430005611,2
    --145314296(+) ATATGC/TAAACA 1 -- us2k10--------
    rs1929523131,2
    --145314304(+) ACAATA/GTTTTC 1 -- us2k10--------
    rs1851548811,2
    C--145314389(+) ATCCTC/TACGTC 1 -- us2k10--------
    rs350472351,2
    C--145314452(+) TTTTT-/T/    
       TA
    /TT
    TTTTT
    1 -- us2k11NA 2
    rs762920791,2
    C--145314454(+) CTCTTT/ATTTTT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1905311921,2
    --145314477(+) TGAGAC/TGGAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SH3RF2 (145316126 - 145461354 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SH3RF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730878CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SH3RF2
    DNA2.0 Custom Variant and Variant Library Synthesis for SH3RF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613377    OMIM disorders: --


    Find genes that share disorders with SH3RF2           About GenesLikeMe

    Genetic Association Database (GAD): SH3RF2
    Human Genome Epidemiology (HuGE) Navigator: SH3RF2 (1 document)

    Export disorders for SH3RF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SH3RF2 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with SH3RF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein. (PubMed id 22128169)1, 3 Wilhelm M....Greene L.A. (J. Biol. Chem. 2012)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. FLJ23654 encodes a heart protein phosphatase 1-binding protein (Hepp1). (PubMed id 19945436)1, 2 Chen C.Y.... Huang H.B. (Biochem. Biophys. Res. Commun. 2010)
    4. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M.... Janssen O. (BMC Immunol. 2009)
    5. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PubMed id 19389623)1, 2 Hendrickx A.... Bollen M. (Chem. Biol. 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. SH3RF2 functions as an oncogene by mediating PAK4 protein stability. (PubMed id 24130170)1 Kim T.W....Park K.C. (Carcinogenesis 2014)
    9. Protein phosphatase 1I^ isoforms linked interactions in the brain. (PubMed id 23080069)1 Esteves S.L....da Cruz e Silva E.F. (J. Mol. Neurosci. 2013)
    10. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 153769 HGNC: 26299 AceView: SH3RF2 Ensembl:ENSG00000156463 euGenes: HUgn153769
    ECgene: SH3RF2 H-InvDB: SH3RF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SH3RF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SH3RF2 gene:
    Search GeneIP for patents involving SH3RF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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