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Aliases for SH3RF2 Gene

Aliases for SH3RF2 Gene

  • SH3 Domain Containing Ring Finger 2 2 3 5
  • Heart Protein Phosphatase 1-Binding Protein 2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 39 2 3
  • Protein Phosphatase 1 Regulatory Subunit 39 3 4
  • SH3 Domain-Containing RING Finger Protein 2 3 4
  • POSH-Eliminating RING Protein 2 3
  • RING Finger Protein 158 3 4
  • PPP1R39 3 4
  • RNF158 3 4
  • HEPP1 3 4
  • Phosphatase 1 Binding Protein 3
  • EC 6.3.2.- 4
  • EC 6.3.2 63
  • POSHER 3

External Ids for SH3RF2 Gene

Previous HGNC Symbols for SH3RF2 Gene

  • PPP1R39

Previous GeneCards Identifiers for SH3RF2 Gene

  • GC05P145345
  • GC05P145296
  • GC05P140462

Summaries for SH3RF2 Gene

GeneCards Summary for SH3RF2 Gene

SH3RF2 (SH3 Domain Containing Ring Finger 2) is a Protein Coding gene. GO annotations related to this gene include ligase activity and protein phosphatase inhibitor activity. An important paralog of this gene is SORBS3.

UniProtKB/Swiss-Prot for SH3RF2 Gene

  • Inhibits PPP1CA phosphatase activity. May be a E3 ubiquitin-protein ligase (Potential). May play a role in cardiac function.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3RF2 Gene

Genomics for SH3RF2 Gene

Regulatory Elements for SH3RF2 Gene

Enhancers for SH3RF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SH3RF2 on UCSC Golden Path with GeneCards custom track

Promoters for SH3RF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SH3RF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SH3RF2 Gene

145,936,563 bp from pter
146,081,791 bp from pter
145,229 bases
Plus strand

Genomic View for SH3RF2 Gene

Genes around SH3RF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3RF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3RF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3RF2 Gene

Proteins for SH3RF2 Gene

  • Protein details for SH3RF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative E3 ubiquitin-protein ligase SH3RF2
    Protein Accession:
    Secondary Accessions:
    • A8K961
    • Q08AM9
    • Q6GMR9
    • Q8N5S8
    • Q96LP8

    Protein attributes for SH3RF2 Gene

    729 amino acids
    Molecular mass:
    79320 Da
    Quaternary structure:
    • Interacts with FASLG and PPP1CA.
    • Sequence=AAH31650.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB85025.1; Type=Erroneous termination; Positions=458; Note=Translated as Trp.; Evidence={ECO:0000305};

    Alternative splice isoforms for SH3RF2 Gene


neXtProt entry for SH3RF2 Gene

Proteomics data for SH3RF2 Gene at MOPED

Selected DME Specific Peptides for SH3RF2 Gene

Post-translational modifications for SH3RF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH3RF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SH3RF2

Domains & Families for SH3RF2 Gene

Suggested Antigen Peptide Sequences for SH3RF2 Gene

Graphical View of Domain Structure for InterPro Entry



  • The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
  • Belongs to the SH3RF family.
  • Contains 1 RING-type zinc finger.
  • The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
  • Contains 3 SH3 domains.
  • Belongs to the SH3RF family.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with SH3RF2: view

Function for SH3RF2 Gene

Molecular function for SH3RF2 Gene

UniProtKB/Swiss-Prot Function:
Inhibits PPP1CA phosphatase activity. May be a E3 ubiquitin-protein ligase (Potential). May play a role in cardiac function.

Enzyme Numbers (IUBMB) for SH3RF2 Gene

Gene Ontology (GO) - Molecular Function for SH3RF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 19389623
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0019902 phosphatase binding IDA 19389623
genes like me logo Genes that share ontologies with SH3RF2: view
genes like me logo Genes that share phenotypes with SH3RF2: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH3RF2 Gene

Localization for SH3RF2 Gene

Subcellular locations from

Jensen Localization Image for SH3RF2 Gene COMPARTMENTS Subcellular localization image for SH3RF2 gene
Compartment Confidence
nucleus 5
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SH3RF2 Gene

Pathways & Interactions for SH3RF2 Gene

SuperPathways for SH3RF2 Gene

No Data Available

UniProtKB/Swiss-Prot Q8TEC5-SH3R2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for SH3RF2 Gene


No data available for Pathways by source and SIGNOR curated interactions for SH3RF2 Gene

Drugs & Compounds for SH3RF2 Gene

No Compound Related Data Available

Transcripts for SH3RF2 Gene

Unigene Clusters for SH3RF2 Gene

SH3 domain containing ring finger 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SH3RF2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b
SP1: - - - - -
SP3: -
SP4: -

Relevant External Links for SH3RF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH3RF2 Gene

mRNA expression in normal human tissues for SH3RF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH3RF2 Gene

This gene is overexpressed in Heart - Left Ventricle (x10.2), Testis (x6.9), Skin - Sun Exposed (Lower leg) (x4.7), Skin - Not Sun Exposed (Suprapubic) (x4.3), and Heart - Atrial Appendage (x4.3).

Protein differential expression in normal tissues from HIPED for SH3RF2 Gene

This gene is overexpressed in Urine (59.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SH3RF2 Gene

SOURCE GeneReport for Unigene cluster for SH3RF2 Gene Hs.443728

mRNA Expression by UniProt/SwissProt for SH3RF2 Gene

Tissue specificity: Heart (at protein level). Heart and testis. In the heart, present in the apex, left atrium, right atrium, left ventricle and right ventricle, but not in the aorta.
genes like me logo Genes that share expression patterns with SH3RF2: view

Protein tissue co-expression partners for SH3RF2 Gene

Primer Products

Orthologs for SH3RF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3RF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PPP1R39 35
  • 88.37 (n)
  • 89.66 (a)
SH3RF2 36
  • 89 (a)
(Canis familiaris)
Mammalia SH3RF2 35
  • 89.43 (n)
  • 90.54 (a)
SH3RF2 36
  • 90 (a)
(Mus musculus)
Mammalia Sh3rf2 35
  • 83.98 (n)
  • 81.62 (a)
Sh3rf2 16
Sh3rf2 36
  • 81 (a)
(Pan troglodytes)
Mammalia SH3RF2 35
  • 99.31 (n)
  • 99.31 (a)
SH3RF2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Sh3rf2 35
  • 84.31 (n)
  • 81.89 (a)
(Monodelphis domestica)
Mammalia SH3RF2 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia SH3RF2 36
  • 67 (a)
(Gallus gallus)
Aves SH3RF2 35
  • 61.4 (n)
  • 57.65 (a)
SH3RF2 36
  • 57 (a)
(Anolis carolinensis)
Reptilia SH3RF2 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3rf2 35
  • 56.77 (n)
  • 50.32 (a)
(Danio rerio)
Actinopterygii SH3RF2 36
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta POSH 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea sorb-1 36
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
Species with no ortholog for SH3RF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3RF2 Gene

Gene Tree for SH3RF2 (if available)
Gene Tree for SH3RF2 (if available)

Paralogs for SH3RF2 Gene

Paralogs for SH3RF2 Gene

(5) SIMAP similar genes for SH3RF2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SH3RF2: view

Variants for SH3RF2 Gene

Sequence variations from dbSNP and Humsavar for SH3RF2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs758037 - 146,013,801(+) CATCC(C/T)GCACA reference, missense
rs2962525 - 146,060,084(+) AGGCC(C/G/T)GGATC reference, missense
rs11435 - 146,062,570(+) TGACC(A/G)TCCTA reference, missense
rs1056149 - 146,062,640(+) TCTTG(A/C/G)CAAGG reference, missense
VAR_052118 -

Structural Variations from Database of Genomic Variants (DGV) for SH3RF2 Gene

Variant ID Type Subtype PubMed ID
esv2730878 CNV Deletion 23290073

Variation tolerance for SH3RF2 Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.60% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SH3RF2 Gene

Disorders for SH3RF2 Gene

Relevant External Links for SH3RF2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SH3RF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3RF2 Gene

Publications for SH3RF2 Gene

  1. Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein. (PMID: 22128169) Wilhelm M. … Greene L.A. (J. Biol. Chem. 2012) 2 3 67
  2. SH3RF2 functions as an oncogene by mediating PAK4 protein stability. (PMID: 24130170) Kim T.W. … Park K.C. (Carcinogenesis 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Protein phosphatase 1I^ isoforms linked interactions in the brain. (PMID: 23080069) Esteves S.L. … da Cruz e Silva E.F. (J. Mol. Neurosci. 2013) 3
  5. Protein phosphatase 1I+ interacting proteins in the human brain. (PMID: 22321011) Esteves S.L. … da Cruz e Silva E.F. (OMICS 2012) 3

Products for SH3RF2 Gene

Sources for SH3RF2 Gene