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SH3RF1 Gene

protein-coding GIFtS: 56

GC04M170251

SH3 domain containing ring finger 1
(Previous name: SH3 multiple domains 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SH3MD2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 6.3.2.- ^³
FLJ21602 ^²
KIAA1494 ^¹, ², ³
POSH ^¹, ², ³
RNF142 ^¹, ², ³
SH3MD2 ^², ³

Descriptions
Plenty of SH3s ^², ³
Protein POSH ^³
RING finger protein 142 ^², ³
SH3 domain containing ring finger 1 ^²
SH3 domain-containing RING finger protein 1 ^³
SH3 multiple domains 2 ^¹, ²
SH3 multiple domains protein 2 ^³
plenty of SH3 domains ^²

External Ids
HGNC: 17650¹
Entrez Gene: 57630²
UniProtKB: Q7Z6J0³
Ensembl: ENSG00000154447⁷

Search outside databases for aliases for SH3RF1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SH3RF1:

This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region

implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been

shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi

network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling

pathway, facilitating the formation of a functional signaling module. [provided by RefSeq]

UniProtKB/Swiss-Prot: SH3R1_HUMAN, Q7Z6J0

Function: Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts

ubiquitin from specific E2 ubiquitin-conjugating enzymes such as UBE2D1 or UBE2N and then

transfers it to substrates. In the absence of an external substrate, it can catalyze

self-ubiquitination

Gene Wiki entry for SH3RF1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SH3RF1 gene

Entrez Gene cytogenetic band: 4q32.3-q33 Ensembl cytogenetic band: 4q33 HGNC cytogenetic band: 4q32.3

SH3RF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M170251: (about GC identifiers)

Start:	170,251,982 bp from pter
End:	170,428,824 bp from pter
Size:	176,843 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000004.10 NT_022792.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SH3R1_HUMAN, Q7Z6J0 (See protein sequence)

Recommended Name: Putative E3 ubiquitin-protein ligase SH3RF1

Size: 888 amino acids; 93129 Da

Subunit: Interacts with Rac; in a GTP-dependent manner (By similarity). Interacts with MAP3K10 and

MAP3K11. Interacts with MAPK8IP; this interaction leads to the PJAC complex (POSH-JIP or

SH3RF1/MAPK8IP apoptotic complex) with a 1:1 ratio. Interacts with SIAH1. Interacts with HERP1.

Probably part of a signaling complex that may contain SH3RF1, MAPK8IP, DLK1, MAP2K4, MAP2K7,

MAPK8, MAPK9, AKT1 and AKT2

Subcellular location: Cytoplasm, perinuclear region (By similarity). Cell projection,

lamellipodium. Cytoplasm. Golgi apparatus, trans-Golgi network. Note=Colocalizes, with AKT2, in

lamellipodia (By similarity). Colocalizes, with HERP1, in trans-Golgi network

Sequence caution: Sequence=AAH33203.1; Type=Frameshift; Positions=182; Sequence=AAH33203.1;

Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

Sequence=AAH53671.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of

unknown origin in the middle of the protein;

Secondary accessions: Q05BT2 Q8IW46 Q9HAM2 Q9P234

Alternative splicing: 2 isoforms: Q7Z6J0-1 Q7Z6J0-3

Post-translational modifications:

Phosphorylated at Ser-304 by AKT1 and AKT2. When phosphorylated, it has reduced ability to bind Rac¹

Subject to ubiquitination and proteasomal degradation (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_065921.2

ENSEMBL proteins:

ENSP00000284637

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (SH3MD2)
	Human Recombinant Proteins from Abnova (SH3MD2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005794	Golgi apparatus	IEA	--
GO:0042995	cell projection	IEA	--

About this table

Antibodies for SH3RF1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for SH3RF1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (SH3MD2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SH3MD2)
	Novus Biologicals Antibodies for SH3RF1

Assays for SH3RF1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q7Z6J0

ProtoNet protein and cluster: Q7Z6J0

1 Blocks protein family: IPB001841 Zn-finger

UniProtKB/Swiss-Prot: SH3R1_HUMAN, Q7Z6J0

Domain: The RING finger domain is responsible of ubiquitination and proteasomal degradation

Similarity: Belongs to the SH3RF family

Similarity: Contains 1 RING-type zinc finger

Similarity: Contains 4 SH3 domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SH3RF1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SH3MD2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_020870

Applied Biosystems Silencer® siRNAs for SH3RF1

Sigma-Aldrich siRNA and siRNA Panels for SH3RF1

Sigma-Aldrich shRNA for SH3RF1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_020870
Myc/DDK tagged cDNA clone in CMV expression vector: NM_020870
untagged cDNA clones in CMV expression vector (see all 4): BC053671

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_020870

UniProtKB/Swiss-Prot: SH3R1_HUMAN, Q7Z6J0

Function: Acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs

(MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably

recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the

sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9) (By similarity). May be

involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane

Function: Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts

ubiquitin from specific E2 ubiquitin-conjugating enzymes such as UBE2D1 or UBE2N and then

transfers it to substrates. In the absence of an external substrate, it can catalyze

self-ubiquitination

Enzyme Number (IUBMB): EC 6.3.2.-

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	17535800
GO:0008270	zinc ion binding	IEA	--
GO:0016874	ligase activity	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for SH3RF1

5/6 Interacting proteins for SH3RF1 (Q7Z6J0¹ ENSP00000284637³) via UniProtKB, MINT, and/or STRING (see all 6 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AKT2	P31751¹, ENSP00000309428³	EBI-311339, EBI-296058 STRING (score=.925)
AKT1	P31749¹, ENSP00000270202³	EBI-311339, EBI-296087 STRING (score=.83)
SIAH1	ENSP00000353090³	STRING (score=.971)
MAPK8	ENSP00000363291³	STRING (score=.958)
MAP3K11	ENSP00000309597³	STRING (score=.753)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SH3RF1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SH3RF1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SH3MD2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_020870

Sigma-Aldrich siRNA and siRNA Panels for SH3RF1

Sigma-Aldrich shRNA for SH3RF1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_020870

REFSEQ mRNAs for SH3RF1 gene:

NM_020870.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_020870

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020870
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_020870
                                 untagged cDNA clones in CMV expression vector (see all 4): BC053671

Additional cDNA sequence:

AB040927.1 AK021429.1 AK025255.1 AK026726.1 BC033203.1 BC041023.1 BC053671.1

7 DOTS entries:

DT.308292 DT.100748160 DT.100009539 DT.101978498 DT.75138116 DT.75195914 DT.91995916

24/106 AceView cDNA sequences (see all 106 ):

NM_020870 CD672041 AL601555 BG166931 N46563 BC041023 BI224417 BI223903

BM836830 BX093287 BX506138 BM722487 CN478827 AA742642 AB040927 BC033203

Z45709 BU619031 BM679006 BI962960 AK026726 AL703694 BF108450 BM827926

highest scoring ESTs for SH3RF1:

AA485805 AI686957 AI871278 AK021429 BC053671 BU159796 CB045141 AA044786 AA044809 AA191323

Unigene Cluster for SH3RF1:

SH3 domain containing ring finger 1

Hs.301804 [show with all ESTs]

Unigene Representative Sequence: BC053671

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SH3RF1 (see all 7 )

ExUns:	1	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14a	·	14b	·	14c	^	15
SP1:			-		-								-
SP2:																									-
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for SH3RF1

1 Ensembl transcript including schematic representation:

ENST00000284637

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SH3RF1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SH3RF1

¹ / ² / ³

8 probe-sets matching SH3RF1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
56001_at²^{, 3}	U95-C	1	1.00	1.00	0.61	0.65	AI637673	0.40	1.00	0.76	1
43090_at²^{, 3}	U95-B	1	1.00	1.00	0.95	0.97	AA485805	0.80	1.00	0.91	1
61632_at²^{, 3}	U95-C	1	1.00	1.00	0.94	1.23	AI871278	0.80	1.00	0.91	1
56002_at²^{, 3}	U95-C	1	0.94	1.00	0.64	1.15	AI686957	0.80	1.00	0.91	1
225590_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI686957	0.80	1.00	0.91	1
225589_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AB040927	0.60	1.00	0.82	1
225590_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
225589_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks SH3RF1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTAATAATTT

SOURCE GeneReport for Unigene cluster: Hs.301804

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SH3RF1 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SH3RF1¹	--	SH3 domain containing ring finger 1	89.23(n) 92.38(a)	612744 XM_843277.1 XP_848370.1
chimpanzee (Pan troglodytes)	SH3RF1¹	--	SH3 domain containing ring finger 1	99.59(n) 99.55(a)	461598 XM_001152752.1 XP_001152752.1
cow (Bos taurus)	SH3RF1¹	--	SH3 domain containing ring finger 1	78.7(n) 83.67(a)	528315 XM_606734.3 XP_606734.3
rat (Rattus norvegicus)	Sh3rf1¹	--	SH3 domain containing ring finger 1	87.01(n) 91.64(a)	306417 NM_198764.1 NP_942059.1
mouse (Mus musculus)	Sh3rf1^{1, 5}	8⁵	SH3 domain containing ring finger 1^{1, 5}	86.21(n)¹ 91.19(a)¹	59009¹ NM_021506.2¹ NP_067481.2¹ AA793086⁵ AF030131⁵ (see all 18)

About this table Species with no ortholog for SH3RF1

ENSEMBL Gene Tree for SH3RF1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SH3RF1 gene

SH3RF2² ENSG00000172985²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/920 NCBI SNPs in SH3RF1 are shown (see all 920 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 303)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs12650909^1,2	A,C,F,H	170429465(+)	`GCCTGA/GAGGAC`	1	--	ng3¹		4		EU EA WA	414
	rs13139803^1,2	C,F,H	170252552(+)	`AACCAC/TATAAA`	1	--	ut3¹		7		NA EU EA WA	562
	rs2706747^1,2	C,F,H	170254083(+)	`CTTCAC/TTCTGC`	1	--	ut3¹		7		EU EA WA NA	556
	rs3749572^1,2	C,F,H	170254244(-)	`TATGAG/AGAGAC`	1	--	ut3¹ ese³		4		EU EA WA	420
	rs3811813^1,2	C,F,H	170274147(+)	`CAGTGG/AAGCAG`	1	S/P	mis¹ ese³		10		EU EA WA NA	1022
	rs6811198^1,2	A,H	170251557(+)	`CATGGG/CCCTTT`	1	--	ng5¹		4		EU EA WA	418
--	rs2245118^1,2	A,C	170252512(-)	`TTTTTA/TAAAAA`	1	--	ut3¹ trp³		0	--	--	--	--
	rs6844899^1,2	F,H	170252770(+)	`GTGGCA/GCCGTA`	1	--	ut3¹ ese³		4		EU EA WA	420
--	rs11936777^1,2	A,C	170428825(+)	`GCGCCC/TGGGGC`	1	--	ng3¹		0	--	--	--	--
--	rs13126712^1,2	H	170313266(+)	`CAGTTT/ATCATC`	1	D/E	mis¹ ese³		4		EU EA WA	406

About this table

HapMap Linkage Disequilibrium images for SH3RF1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/16 PubMed articles for SH3RF1 gene (see all 16 ):

Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex. (PubMed id 14504284)^{1, 3, 4} Figueroa C....Vojtek A.B. (2003)
Regulation of the pro-apoptotic scaffolding protein POSH by Akt. (PubMed id 17535800)^{3, 4} Lyons T.R....Kassenbrock C.K. (2007)
The trans-Golgi network-associated human ubiquitin-protein ligase POSH is essential for HIV type 1 production. (PubMed id 15659549)^{3, 4} Alroy I.... Reiss Y. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)^{3, 4} Nagase T....Ohara O. (2000)
A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways. (PubMed id 9482736)^{2, 3} Tapon N....Hall A. (1998)
The ubiquitin E3 ligase POSH regulates calcium homeostasis through spatial control of Herp. (PubMed id 17420289)⁴ Tuvia S.... Reiss Y. (2007)
Siah1 interacts with the scaffold protein POSH to promote JNK activation and apoptosis. (PubMed id 16230351)⁴ Xu Z....Greene L.A. (2006)
Direct interaction of the molecular scaffolds POSH and JIP is required for apoptotic activation of JNKs. (PubMed id 16571722)⁴ Kukekov N.V.... Greene L.A. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 57630	HGNC: 17650	AceView: SH3MD2	Ensembl:ENSG00000154447	euGenes: HUgn57630
ECgene: SH3RF1	H-InvDB: SH3RF1

(According to HUGE)
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HUGE: KIAA1494

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for SH3RF1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for SH3RF1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SH3RF1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SH3RF1		Antibodies for SH3RF1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SH3RF1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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Antibodies for SH3RF1

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SH3RF1 Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for SH3RF1

Summaries
for SH3RF1

Genomic Location
for SH3RF1

Proteins
for SH3RF1

Protein Domains/
Families
for SH3RF1

Gene Function
for SH3RF1

Pathways & Interactions
for SH3RF1

Drugs & Compounds
for SH3RF1

Transcripts
for SH3RF1

Expression
for SH3RF1

Orthologs
for SH3RF1

Paralogs
for SH3RF1

SNPs/Variants
for SH3RF1

Disorders & Mutations
for SH3RF1

Medical News
for SH3RF1

Publications
for SH3RF1

Search for SH3RF1

Genome Databases showing SH3RF1

Other Databases showing SH3RF1

Specialized Databases showing SH3RF1

Licensable Technologies
for SH3RF1

Services
for SH3RF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SH3RF1 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor SH3RF1

Summariesfor SH3RF1

Genomic Locationfor SH3RF1

Proteinsfor SH3RF1

Protein Domains/Familiesfor SH3RF1

Gene Functionfor SH3RF1

Pathways & Interactionsfor SH3RF1

Drugs & Compoundsfor SH3RF1

Transcriptsfor SH3RF1

Expression for SH3RF1

Orthologsfor SH3RF1

Paralogsfor SH3RF1

SNPs/Variantsfor SH3RF1

Disorders & Mutationsfor SH3RF1

Medical Newsfor SH3RF1

Publicationsfor SH3RF1

Search for SH3RF1

Genome Databases showing SH3RF1

Other Databases showing SH3RF1

Specialized Databases showing SH3RF1

Licensable Technologiesfor SH3RF1

Servicesfor SH3RF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SH3RF1

Summaries
for SH3RF1

Genomic Location
for SH3RF1

Proteins
for SH3RF1

Protein Domains/
Families
for SH3RF1

Gene Function
for SH3RF1

Pathways & Interactions
for SH3RF1

Drugs & Compounds
for SH3RF1

Transcripts
for SH3RF1

Expression
for SH3RF1

Orthologs
for SH3RF1

Paralogs
for SH3RF1

SNPs/Variants
for SH3RF1

Disorders & Mutations
for SH3RF1

Medical News
for SH3RF1

Publications
for SH3RF1

Licensable Technologies
for SH3RF1

Services
for SH3RF1