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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SH3PXD2A Gene

protein-coding   GIFtS: 54
GCID: GC10M105345

SH3 And PX Domains 2A

(Previous name: SH3 multiple domains 1)
(Previous symbol: SH3MD1)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SH3 And PX Domains 2A1 2     TKS52 3
SH3MD11 2 3     Five SH3 Domains1
SH3 Multiple Domains 11 2     Adaptor Protein TKS52
Adapter Protein TKS52 3     SH3 And PX Domain-Containing Protein 2A2
Five SH3 Domain-Containing Protein2 3     KIAA04183
Tyrosine Kinase Substrate With Five SH3 Domains2 3     SH3 Multiple Domains Protein 13
FISH2 3     

External Ids:    HGNC: 236641   Entrez Gene: 96442   Ensembl: ENSG000001079577   UniProtKB: Q5TCZ13   

Export aliases for SH3PXD2A gene to outside databases

Previous GC identifer: GC10M098984


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SH3PXD2A Gene: 
SH3PXD2A (SH3 and PX domains 2A) is a protein-coding gene. Diseases associated with SH3PXD2A include alzheimer's disease, and melanoma. GO annotations related to this gene include protein binding and phosphatidylinositol binding. An important paralog of this gene is SH3PXD2B.

UniProtKB/Swiss-Prot: SPD2A_HUMAN, Q5TCZ1
Function: Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and
invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and
phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS)
generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid
peptide

Gene Wiki entry for SH3PXD2A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SH3PXD2A gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SH3PXD2A promoter sequence
   Search SABiosciences Chromatin IP Primers for SH3PXD2A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH3PXD2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.33   Ensembl cytogenetic band:  10q24.33   HGNC cytogenetic band: 10q25.1

SH3PXD2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SH3PXD2A gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M105345:  view genomic region     (about GC identifiers)

Start:
105,348,285 bp from pter      End:
105,615,301 bp from pter
Size:
267,017 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPD2A_HUMAN, Q5TCZ1 (See protein sequence)
Recommended Name: SH3 and PX domain-containing protein 2A  
Size: 1133 amino acids; 125289 Da
Subunit: Interacts (via N-terminus) with CYBA (By similarity). Interacts with ADAM12, ADAM15 and ADAM19. Interacts
with NOXO1. Interacts (via SH3 domains) with NOXA1. Interacts with FASLG
Subcellular location: Cytoplasm. Cell projection, podosome. Note=Cytoplasmic in normal cells and localizes to
podosomes in SRC-transformed cells
Sequence caution: Sequence=BAA24848.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
4 PDB 3D structures from and Proteopedia for SH3PXD2A:
2DNU (3D)        2EGA (3D)        2EGC (3D)        2EKH (3D)    
Secondary accessions: D3DR98 O43302 Q5TCZ2 Q5TDQ8
Alternative splicing: 3 isoforms:  Q5TCZ1-1   Q5TCZ1-2   Q5TCZ1-3   (Gene prediction based on similarity to mouse ortholog and partial transcript data)

Explore the universe of human proteins at neXtProt for SH3PXD2A: NX_Q5TCZ1

Explore proteomics data for SH3PXD2A at MOPED 

Post-translational modifications:

  • UniProtKB: Tyrosine phosphorylated by SRC. Phosphorylation plays a regulatory role in the protein localization. The
    intramolecular interaction of the PX domain with the third SH3 domain maintains the protein in the cytoplasm and
    phosphorylation disrupts this interaction, resulting in the redistribution of the protein from cytoplasm to the
    perimembrane region. Phosphorylated on serine upon DNA damage, probably by ATM or ATR
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5TCZ1

  • SH3PXD2A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SH3PXD2A Protein Expression
    REFSEQ proteins: NP_055446.2  
    ENSEMBL proteins: 
     ENSP00000358789   ENSP00000395781   ENSP00000392664   ENSP00000348215   ENSP00000443663  
     ENSP00000441514  

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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002102podosome IDA18417249
    GO:0005737cytoplasm IEA--
    GO:0030054cell junction IEA--
    GO:0042995cell projection IEA--

    SH3PXD2A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011511 SH3_2
     IPR001683 Phox
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q5TCZ1

    ProtoNet protein and cluster: Q5TCZ1

    1 Blocks protein domain: IPB001683 Phox-like

    UniProtKB/Swiss-Prot: SPD2A_HUMAN, Q5TCZ1
    Domain: The PX domain is required for podosome localization because of its ability to bind phosphatidylinositol
    3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and, to a lesser extent,
    phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P), and
    phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Binds to the third intramolecular SH3 domain (By
    similarity)
    Domain: The fifth SH3 domain mediates binding with ADAM12, ADAM15 and ADAM19
    Similarity: Belongs to the SH3PXD2 family
    Similarity: Contains 1 PX (phox homology) domain
    Similarity: Contains 5 SH3 domains


    SH3PXD2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPD2A_HUMAN, Q5TCZ1
    Function: Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and
    invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and
    phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS)
    generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid
    peptide

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16374509
    GO:0035091phosphatidylinositol binding IEA--
         
    SH3PXD2A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SH3PXD2A:
     Metaphase cells 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SH3PXD2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/31 Interacting proteins for SH3PXD2A (Q5TCZ12, 3 ENSP000003482154) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADAM15Q134442, 3, ENSP000003494364MINT-2792498 MINT-2792970 I2D: score=4 STRING: ENSP00000349436
    MED28Q9H2042, 3, ENSP000002373804MINT-7104502 I2D: score=1 STRING: ENSP00000237380
    SOS1Q078892, 3, ENSP000003846754MINT-7230778 MINT-7230618 MINT-7230853 MINT-7230642 MINT-7230689 MINT-7230708 MINT-7230670 I2D: score=1 STRING: ENSP00000384675
    PAK2Q131772, 3, ENSP000003140674MINT-2792128 I2D: score=2 STRING: ENSP00000314067
    PRKAB2O437413, ENSP000002541014I2D: score=3 STRING: ENSP00000254101
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006801superoxide metabolic process IMP--
    GO:0007154cell communication IEA--
    GO:0072593reactive oxygen species metabolic process ----

    SH3PXD2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SH3PXD2A (SPD2A)

    Search CenterWatch for drugs/clinical trials and news about SH3PXD2A / SPD2A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SH3PXD2A gene: 
    NM_014631.2  

    Unigene Cluster for SH3PXD2A:

    SH3 and PX domains 2A
    Hs.678727  [show with all ESTs]
    Unigene Representative Sequence: NM_014631
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369774(uc010qqs.1 uc010qqt.1 uc009xxn.1 uc010qqu.1 uc001kxj.1)
    ENST00000315994 ENST00000420222 ENST00000427662(uc010qqr.2) ENST00000355946
    ENST00000540321 ENST00000538130

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    Additional mRNA sequence: 

    AB007878.1 AK025783.1 AK056469.1 AK096575.1 AK123570.1 AK294454.1 AK294736.1 AK295314.1 
    AK295660.1 AK302015.1 AK304828.1 AK315983.1 AL833070.2 BX647371.1 

    14 DOTS entries:

    DT.95263200  DT.454491  DT.409630  DT.95137847  DT.75196752  DT.99937522  DT.95360222  DT.102843551 
    DT.121244842  DT.40272855  DT.405394  DT.92422740  DT.100706392  DT.121244706 

    24/269 AceView cDNA sequences (see all 269):

    AI086931 AA595636 BF589261 BU167416 AW105640 BQ575447 BP337958 AA253247 
    CA422263 BE671178 W58619 CD722666 CA431254 AI418000 BM984750 AW250204 
    BM982064 BU162089 AI364156 BU623843 AI185975 AI081101 CR608729 AI654886 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SH3PXD2A expression in normal human tissues (normalized intensities)      SH3PXD2A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATCTTATAT
    SH3PXD2A Expression
    About this image


    SH3PXD2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer

    See SH3PXD2A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SH3PXD2A

    SOURCE GeneReport for Unigene cluster: Hs.678727

    UniProtKB/Swiss-Prot: SPD2A_HUMAN, Q5TCZ1
    Tissue specificity: Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas

        SABiosciences Expression via Pathway-Focused PCR Arrays including SH3PXD2A: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Cell Motility in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SH3PXD2A gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sh3pxd2a1 , 5 SH3 and PX domains 2A1, 5 86.92(n)1
    91.7(a)1
      19 (39.45 cM)5
    142181  NM_008018.41  NP_032044.21 
     472601745 
    chicken
    (Gallus gallus)
    Aves SH3PXD2A1 SH3 and PX domains 2A 72.77(n)
    80.46(a)
      423876  XM_421741.3  XP_421741.3 
    lizard
    (Anolis carolinensis)
    Reptilia SH3PXD2A6
    SH3 and PX domains 2A
    72(a)
    1 ↔ 1
    3(41004831-41126118)
    zebrafish
    (Danio rerio)
    Actinopterygii sh3pxd2aa1 SH3 and PX domains 2Aa 61.25(n)
    62.34(a)
      562018  NM_001160022.1  NP_001153494.1 


    ENSEMBL Gene Tree for SH3PXD2A (if available)
    TreeFam Gene Tree for SH3PXD2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SH3PXD2A gene
    SH3PXD2B2  NOXO12  NCF12  
    18/41 SIMAP similar genes for SH3PXD2A using alignment to 5 protein entries:     SPD2A_HUMAN (see all proteins) (see all similar genes):
    RNF217    AGBL3    AURA2    ZNF737    SPATS2L    NF2
    NFS1    TMEM14B    LYRM4    C4orf22    TCF4    ZNF564
    TSEN2    UTY    DNAPTP3    FAM175A    GVQW1    SEPT2

    SH3PXD2A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4742 SNPs in SH3PXD2A are shown (see all 4742)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs343112111,2
    C--99059110(+) GAGAG-/AG/GA 
            
    AACGG
    1 -- int10--------
    rs1826624531,2
    --105353459(+) AAATAA/GTAGAA 1 -- ds50010--------
    rs1497007041,2
    --105353529(+) AGGATC/TGCTTG 1 -- ds50010--------
    rs3687740171,2
    C--105353613(+) CCTGT-/AAAAAA 1 -- ds50010--------
    rs352673771,2
    C--105353628(+) AAAAA-/A/AA  
            
    GCGAG
    1 -- ds50011NA 2
    rs1872461711,2
    --105353787(+) CGTTCA/GGTTAA 1 -- ut310--------
    rs1921181641,2
    --105353875(+) CTTACA/GGTCTA 1 -- ut310--------
    rs1831518561,2
    --105354234(+) ATTCTC/TCAAGG 1 -- ut310--------
    rs70849361,2
    C--105354296(+) ATGCTA/CACGCT 1 -- ut310--------
    rs1158240201,2
    C,F--105354330(+) TGCCCG/AGGAGT 1 -- ut311Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for SH3PXD2A (105348285 - 105598285 bp, first 250kb of SH3PXD2A)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for SH3PXD2A (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2072570CNV Deletion18987734
    esv1393174CNV Deletion17803354
    esv2740350CNV Deletion23290073
    dgv115e201CNV Deletion23290073
    esv2740362CNV Deletion23290073
    esv2740339CNV Deletion23290073
    esv2740295CNV Deletion23290073
    esv2114347CNV Deletion18987734
    esv2673767CNV Deletion23128226
    esv2740317CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for SH3PXD2A:    About MalaCards
    alzheimer's disease    melanoma


    SH3PXD2A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): SH3PXD2A
    Human Genome Epidemiology (HuGE) Navigator: SH3PXD2A (3 documents)

    Export disorders for SH3PXD2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SH3PXD2A gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with SH3PXD2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A study of the association between the ADAM12 and SH3 PXD2A (SH3MD1) genes and Alzheimer's disease. (PubMed id 19837132)1, 4, 9 Laumet G....Lambert J.C. (2010)
    2. Direct interaction between Tks proteins and the N-terminal proline- rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation. (PubMed id 20609497)1, 2 Gianni D.... Bokoch G.M. (2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M....Janssen O. (2009)
    5. Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity. (PubMed id 19755710)1, 2 Gianni D....Bokoch G.M. (2009)
    6. A role for the podosome/invadopodia scaffold protein Tks5 in tumor growth in vivo. (PubMed id 18417249)1, 2 Blouw B....Courtneidge S.A. (2008)
    7. The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells. (PubMed id 15710328)1, 2 Seals D.F.... Courtneidge S.A. (2005)
    8. Amyloid-beta neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity. (PubMed id 15710903)1, 2 Malinin N.L.... Griswold-Prenner I. (2005)
    9. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    10. The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells. (PubMed id 12615925)1, 2 Abram C.L....Courtneidge S.A. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9644 HGNC: 23664 AceView: SH3MD1 Ensembl:ENSG00000107957 euGenes: HUgn9644
    ECgene: SH3PXD2A H-InvDB: SH3PXD2A

    (According to HUGE)
    About This Section
    HUGE: KIAA0418

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SH3PXD2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SH3PXD2A gene:
    Search GeneIP for patents involving SH3PXD2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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