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Aliases for SH3PXD2A Gene

Aliases for SH3PXD2A Gene

  • SH3 And PX Domains 2A 2 3
  • Tyrosine Kinase Substrate With Five SH3 Domains 3 4
  • Five SH3 Domain-Containing Protein 3 4
  • SH3 Multiple Domains 1 2 3
  • Adapter Protein TKS5 3 4
  • SH3MD1 3 4
  • FISH 3 4
  • TKS5 3 4
  • SH3 And PX Domain-Containing Protein 2A 3
  • SH3 Multiple Domains Protein 1 4
  • Adaptor Protein TKS5 3
  • Five SH3 Domains 2
  • KIAA0418 4

External Ids for SH3PXD2A Gene

Previous HGNC Symbols for SH3PXD2A Gene

  • SH3MD1

Previous GeneCards Identifiers for SH3PXD2A Gene

  • GC10M105345
  • GC10M098984

Summaries for SH3PXD2A Gene

GeneCards Summary for SH3PXD2A Gene

SH3PXD2A (SH3 And PX Domains 2A) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SH3PXD2B.

UniProtKB/Swiss-Prot for SH3PXD2A Gene

  • Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.

Gene Wiki entry for SH3PXD2A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3PXD2A Gene

Genomics for SH3PXD2A Gene

Regulatory Elements for SH3PXD2A Gene

Transcription factor binding sites by QIAGEN in the SH3PXD2A gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SH3PXD2A Gene

Start:
103,594,027 bp from pter
End:
103,855,543 bp from pter
Size:
261,517 bases
Orientation:
Minus strand

Genomic View for SH3PXD2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SH3PXD2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3PXD2A Gene

Proteins for SH3PXD2A Gene

  • Protein details for SH3PXD2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TCZ1-SPD2A_HUMAN
    Recommended name:
    SH3 and PX domain-containing protein 2A
    Protein Accession:
    Q5TCZ1
    Secondary Accessions:
    • D3DR98
    • O43302
    • Q5TCZ2
    • Q5TDQ8

    Protein attributes for SH3PXD2A Gene

    Size:
    1133 amino acids
    Molecular mass:
    125289 Da
    Quaternary structure:
    • Interacts (via N-terminus) with CYBA (By similarity). Interacts with ADAM12, ADAM15 and ADAM19. Interacts with NOXO1. Interacts (via SH3 domains) with NOXA1. Interacts with FASLG.
    SequenceCaution:
    • Sequence=BAA24848.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SH3PXD2A Gene

    Alternative splice isoforms for SH3PXD2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH3PXD2A Gene

Proteomics data for SH3PXD2A Gene at MOPED

Post-translational modifications for SH3PXD2A Gene

  • Tyrosine phosphorylated by SRC. Phosphorylation plays a regulatory role in the protein localization. The intramolecular interaction of the PX domain with the third SH3 domain maintains the protein in the cytoplasm and phosphorylation disrupts this interaction, resulting in the redistribution of the protein from cytoplasm to the perimembrane region. Phosphorylated on serine upon DNA damage, probably by ATM or ATR
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH3PXD2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SH3PXD2A Gene

Domains for SH3PXD2A Gene

Protein Domains for SH3PXD2A Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5TCZ1

UniProtKB/Swiss-Prot:

SPD2A_HUMAN :
  • Q5TCZ1
Domain:
  • The PX domain is required for podosome localization because of its ability to bind phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and, to a lesser extent, phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Binds to the third intramolecular SH3 domain (By similarity).
  • The fifth SH3 domain mediates binding with ADAM12, ADAM15 and ADAM19.
  • Contains 1 PX (phox homology) domain.
  • Contains 5 SH3 domains.
Family:
  • Belongs to the SH3PXD2 family.
genes like me logo Genes that share domains with SH3PXD2A: view

No data available for Gene Families for SH3PXD2A Gene

Function for SH3PXD2A Gene

Molecular function for SH3PXD2A Gene

UniProtKB/Swiss-Prot Function: Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.

Gene Ontology (GO) - Molecular Function for SH3PXD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16374509
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with SH3PXD2A: view

Phenotypes for SH3PXD2A Gene

GenomeRNAi human phenotypes for SH3PXD2A:
genes like me logo Genes that share phenotypes with SH3PXD2A: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SH3PXD2A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SH3PXD2A Gene

Localization for SH3PXD2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH3PXD2A Gene

Cytoplasm. Cell projection, podosome. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SH3PXD2A Gene COMPARTMENTS Subcellular localization image for SH3PXD2A gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for SH3PXD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002102 podosome IDA 18417249
GO:0005737 cytoplasm IEA --
GO:0030054 cell junction IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with SH3PXD2A: view

Pathways for SH3PXD2A Gene

SuperPathways for SH3PXD2A Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SH3PXD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006801 superoxide metabolic process IMP 20609497
GO:0072593 reactive oxygen species metabolic process --
GO:0072675 osteoclast fusion IMP 22584907
genes like me logo Genes that share ontologies with SH3PXD2A: view

No data available for Pathways by source for SH3PXD2A Gene

Transcripts for SH3PXD2A Gene

Unigene Clusters for SH3PXD2A Gene

SH3 and PX domains 2A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SH3PXD2A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SH3PXD2A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3PXD2A Gene

No ASD Table

Relevant External Links for SH3PXD2A Gene

GeneLoc Exon Structure for
SH3PXD2A
ECgene alternative splicing isoforms for
SH3PXD2A

Expression for SH3PXD2A Gene

mRNA expression in normal human tissues for SH3PXD2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SH3PXD2A Gene

SOURCE GeneReport for Unigene cluster for SH3PXD2A Gene Hs.678727

mRNA Expression by UniProt/SwissProt for SH3PXD2A Gene

Q5TCZ1-SPD2A_HUMAN
Tissue specificity: Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas.
genes like me logo Genes that share expressions with SH3PXD2A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SH3PXD2A Gene

Orthologs for SH3PXD2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for SH3PXD2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SH3PXD2A 35
  • 99.1 (n)
  • 99.46 (a)
cow
(Bos Taurus)
Mammalia SH3PXD2A 35
  • 90.11 (n)
  • 93.02 (a)
SH3PXD2A 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SH3PXD2A 35
  • 89.56 (n)
  • 92.4 (a)
SH3PXD2A 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sh3pxd2a 35
  • 86.89 (n)
  • 91.61 (a)
Sh3pxd2a 16
Sh3pxd2a 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SH3PXD2A 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SH3PXD2A 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sh3pxd2a 35
  • 86.86 (n)
  • 91.58 (a)
chicken
(Gallus gallus)
Aves SH3PXD2A 35
  • 72.93 (n)
  • 80.15 (a)
SH3PXD2A 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SH3PXD2A 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3pxd2a 35
  • 66.82 (n)
  • 71.07 (a)
zebrafish
(Danio rerio)
Actinopterygii sh3pxd2aa 35
  • 62.99 (n)
  • 64.11 (a)
sh3pxd2aa 36
  • 57 (a)
OneToMany
sh3pxd2ab 36
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for SH3PXD2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SH3PXD2A Gene

ENSEMBL:
Gene Tree for SH3PXD2A (if available)
TreeFam:
Gene Tree for SH3PXD2A (if available)

Paralogs for SH3PXD2A Gene

Paralogs for SH3PXD2A Gene

genes like me logo Genes that share paralogs with SH3PXD2A: view

Variants for SH3PXD2A Gene

Sequence variations from dbSNP and Humsavar for SH3PXD2A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs9521 -- 103,598,701(-) CTGCC(C/G)GCAGC utr-variant-3-prime
rs10879 -- 103,594,799(-) TTAGA(C/T)TGGGT utr-variant-3-prime
rs725076 -- 103,821,507(-) ATTGT(A/C)AAGGT intron-variant
rs725077 -- 103,821,490(-) TAAGC(C/T)TCCCT intron-variant
rs728713 -- 103,792,691(+) GGAGC(A/G)CATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH3PXD2A Gene

Variant ID Type Subtype PubMed ID
nsv524966 CNV Loss 19592680
nsv895981 CNV Loss 21882294
nsv7530 CNV Insertion 18451855
esv1007127 CNV Loss 20482838
esv2740295 CNV Deletion 23290073
esv2072570 CNV Deletion 18987734
esv2114347 CNV Deletion 18987734
esv1393174 CNV Deletion 17803354
dgv115e201 CNV Deletion 23290073
esv2740317 CNV Deletion 23290073
esv2673767 CNV Deletion 23128226
nsv516106 CNV Loss 19592680
nsv522595 CNV Gain 19592680
nsv518657 CNV Gain 19592680
esv2740339 CNV Deletion 23290073
esv2740350 CNV Deletion 23290073
esv2740362 CNV Deletion 23290073

Relevant External Links for SH3PXD2A Gene

HapMap Linkage Disequilibrium report
SH3PXD2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3PXD2A Gene

Disorders for SH3PXD2A Gene

Relevant External Links for SH3PXD2A

Genetic Association Database (GAD)
SH3PXD2A
Human Genome Epidemiology (HuGE) Navigator
SH3PXD2A
genes like me logo Genes that share disorders with SH3PXD2A: view

No data available for UniProtKB/Swiss-Prot for SH3PXD2A Gene

Publications for SH3PXD2A Gene

  1. A study of the association between the ADAM12 and SH3PXD2A (SH3MD1) genes and Alzheimer's disease. (PMID: 19837132) Laumet G. … Lambert J.C. (Neurosci. Lett. 2010) 3 23 48
  2. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 3 4
  3. A new method for isolating tyrosine kinase substrates used to identify fish, an SH3 and PX domain-containing protein, and Src substrate. (PMID: 9687503) Lock P. … Courtneidge S.A. (EMBO J. 1998) 2 3
  4. The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells. (PMID: 12615925) Abram C.L. … Courtneidge S.A. (J. Biol. Chem. 2003) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4

Products for SH3PXD2A Gene

  • antibodies-online peptides for SH3PXD2A
  • antibodies-online antibodies for SH3PXD2A
  • antibodies-online kits for SH3PXD2A

Sources for SH3PXD2A Gene

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