Aliases for SH3PXD2A Gene
External Ids for SH3PXD2A Gene
Previous Symbols for SH3PXD2A Gene
GeneCards Summary for SH3PXD2A Gene
SH3PXD2A (SH3 And PX Domains 2A) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SH3PXD2B.
UniProtKB/Swiss-Prot for SH3PXD2A Gene
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.