Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SH3PXD2A Gene

protein-coding   GIFtS: 50
GCID: GC10M105345

SH3 And PX Domains 2A

(Previous name: SH3 multiple domains 1)
(Previous symbol: SH3MD1)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
SH3 And PX Domains 2A1 2     TKS52 3
SH3MD11 2 3     Five SH3 Domains1
SH3 Multiple Domains 11 2     Adaptor Protein TKS52
Adapter Protein TKS52 3     SH3 And PX Domain-Containing Protein 2A2
Five SH3 Domain-Containing Protein2 3     KIAA04183
Tyrosine Kinase Substrate With Five SH3 Domains2 3     SH3 Multiple Domains Protein 13
FISH2 3     

External Ids:    HGNC: 236641   Entrez Gene: 96442   Ensembl: ENSG000001079577   UniProtKB: Q5TCZ13   

Export aliases for SH3PXD2A gene to outside databases

Previous GC identifer: GC10M098984


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SH3PXD2A Gene:
SH3PXD2A (SH3 and PX domains 2A) is a protein-coding gene. GO annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SH3PXD2B.

UniProtKB/Swiss-Prot: SPD2A_HUMAN, Q5TCZ1
Function: Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and
invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and
phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS)
generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid
peptide

Gene Wiki entry for SH3PXD2A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the SH3PXD2A gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SH3PXD2A promoter sequence
   Search Chromatin IP Primers for SH3PXD2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SH3PXD2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.33   Ensembl cytogenetic band:  10q24.33   HGNC cytogenetic band: 10q25.1

SH3PXD2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SH3PXD2A gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M105345:  view genomic region     (about GC identifiers)

Start:
105,348,285 bp from pter      End:
105,615,301 bp from pter
Size:
267,017 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SPD2A_HUMAN, Q5TCZ1 (See protein sequence)
Recommended Name: SH3 and PX domain-containing protein 2A  
Size: 1133 amino acids; 125289 Da
Subunit: Interacts (via N-terminus) with CYBA (By similarity). Interacts with ADAM12, ADAM15 and ADAM19. Interacts
with NOXO1. Interacts (via SH3 domains) with NOXA1. Interacts with FASLG
Sequence caution: Sequence=BAA24848.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
4 PDB 3D structures from and Proteopedia for SH3PXD2A:
2DNU (3D)        2EGA (3D)        2EGC (3D)        2EKH (3D)    
Secondary accessions: D3DR98 O43302 Q5TCZ2 Q5TDQ8
Alternative splicing: 3 isoforms:  Q5TCZ1-1   Q5TCZ1-2   Q5TCZ1-3   (Gene prediction based on similarity to mouse ortholog and partial transcript data)

Explore the universe of human proteins at neXtProt for SH3PXD2A: NX_Q5TCZ1

Explore proteomics data for SH3PXD2A at MOPED

Post-translational modifications: 

  • Tyrosine phosphorylated by SRC. Phosphorylation plays a regulatory role in the protein localization. The
    intramolecular interaction of the PX domain with the third SH3 domain maintains the protein in the cytoplasm and
    phosphorylation disrupts this interaction, resulting in the redistribution of the protein from cytoplasm to the
    perimembrane region. Phosphorylated on serine upon DNA damage, probably by ATM or ATR1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SH3PXD2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055446.2  
    ENSEMBL proteins: 
     ENSP00000358789   ENSP00000395781   ENSP00000392664   ENSP00000348215   ENSP00000443663  
     ENSP00000441514  

    SH3PXD2A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SH3PXD2A
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SH3PXD2A
    GenScript Custom Purified and Recombinant Proteins Services for SH3PXD2A
    Novus Biologicals SH3PXD2A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SH3PXD2A

     
    Search eBioscience for Proteins for SH3PXD2A 

     
    Search antibodies-online for proteins for SH3PXD2A 

     
    antibodies-online peptides for SH3PXD2A

    SH3PXD2A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SH3PXD2A
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SH3PXD2A
    OriGene Custom Antibody Services for SH3PXD2A
    Novus Biologicals SH3PXD2A Antibodies
    Search for Antibodies for SH3PXD2A at Abcam
    Cloud-Clone Corp. Antibodies for SH3PXD2A
    Search ThermoFisher Antibodies for SH3PXD2A
    LSBio Antibodies in human, mouse, rat for SH3PXD2A
    antibodies-online antibodies for SH3PXD2A (30 products) 

    SH3PXD2A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SH3PXD2A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SH3PXD2A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SH3PXD2A
    Cloud-Clone Corp. CLIAs for SH3PXD2A
    Search eBioscience for ELISAs for SH3PXD2A 
    antibodies-online kits for SH3PXD2A (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR001683 Phox
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q5TCZ1

    ProtoNet protein and cluster: Q5TCZ1

    1 Blocks protein domain: IPB001683 Phox-like

    UniProtKB/Swiss-Prot: SPD2A_HUMAN, Q5TCZ1
    Domain: The PX domain is required for podosome localization because of its ability to bind phosphatidylinositol
    3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and, to a lesser extent,
    phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P), and
    phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Binds to the third intramolecular SH3 domain (By
    similarity)
    Domain: The fifth SH3 domain mediates binding with ADAM12, ADAM15 and ADAM19
    Similarity: Belongs to the SH3PXD2 family
    Similarity: Contains 1 PX (phox homology) domain
    Similarity: Contains 5 SH3 domains


    Find genes that share domains with SH3PXD2A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPD2A_HUMAN, Q5TCZ1
    Function: Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and
    invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and
    phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS)
    generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid
    peptide

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16374509
    GO:0035091phosphatidylinositol binding IEA--
         
    Find genes that share ontologies with SH3PXD2A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SH3PXD2A:
     Metaphase cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SH3PXD2A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SH3PXD2A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SH3PXD2A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SH3PXD2A

    miRNA
    Products:
        
    miRTarBase miRNAs that target SH3PXD2A:
    hsa-let-7b-5p (MIRT052098), hsa-mir-33a-5p (MIRT028217), hsa-mir-24-3p (MIRT035542), hsa-mir-130b-3p (MIRT020272), hsa-mir-93-5p (MIRT028101), hsa-mir-335-5p (MIRT019047), hsa-mir-331-3p (MIRT043337), hsa-mir-124-3p (MIRT023125)

    Block miRNA regulation of human, mouse, rat SH3PXD2A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SH3PXD2A (see all 172):
    hsa-miR-26a-2* hsa-miR-3938 hsa-miR-199a-3p hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-502-3p hsa-miR-149
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SH3PXD2A
    Predesigned siRNA for gene silencing in human, mouse, rat SH3PXD2A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SH3PXD2A

    Clone
    Products:
         
    OriGene clones in human, mouse for SH3PXD2A (see all 7)
    OriGene ORF clones in mouse, rat for SH3PXD2A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SH3PXD2A (NM_014631)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SH3PXD2A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH3PXD2A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SH3PXD2A
    Browse ESI BIO Cell Lines and PureStem Progenitors for SH3PXD2A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3PXD2A

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-14319 VA6-14241) for SH3PXD2A 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SPD2A_HUMAN, Q5TCZ1: Cytoplasm. Cell projection, podosome. Note=Cytoplasmic in normal cells and localizes to
    podosomes in SRC-transformed cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002102podosome IDA18417249
    GO:0005737cytoplasm IEA--
    GO:0030054cell junction IEA--
    GO:0042995cell projection IEA--

    Find genes that share ontologies with SH3PXD2A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Pathway & Disease-focused RT2 Profiler PCR Arrays including SH3PXD2A: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SH3PXD2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SH3PXD2A (Q5TCZ11, 2, 3 ENSP000003482154) via UniProtKB, MINT, STRING, and/or I2D (see all 128)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SOS1Q078891, 2, 3, ENSP000003846754EBI-7014859,EBI-297487 MINT-7230778 MINT-7230618 MINT-7230853 MINT-7230642 MINT-7230689 MINT-7230708 MINT-7230670 I2D: score=1 STRING: ENSP00000384675
    MED28Q9H2042, 3, ENSP000002373804MINT-7104502 I2D: score=1 STRING: ENSP00000237380
    ADAM15Q134441, 2, 3, ENSP000003494364EBI-2483234,EBI-77818 MINT-2792498 MINT-2792970 I2D: score=4 STRING: ENSP00000349436
    PAK2Q131772, 3, ENSP000003140674MINT-2792128 I2D: score=2 STRING: ENSP00000314067
    PRKAA2P546463, ENSP000003602904I2D: score=3 STRING: ENSP00000360290
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006801superoxide metabolic process IMP--
    GO:0007154cell communication ----
    GO:0072593reactive oxygen species metabolic process ----

    Find genes that share ontologies with SH3PXD2A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SH3PXD2A (SPD2A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SH3PXD2A gene: 
    NM_014631.2  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369774(uc010qqs.1 uc010qqt.1 uc009xxn.1 uc010qqu.1 uc001kxj.1)
    ENST00000315994 ENST00000420222 ENST00000427662(uc010qqr.2) ENST00000355946
    ENST00000540321 ENST00000538130
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SH3PXD2A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SH3PXD2A (see all 172):
    hsa-miR-26a-2* hsa-miR-3938 hsa-miR-199a-3p hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-502-3p hsa-miR-149
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SH3PXD2A
    Predesigned siRNA for gene silencing in human, mouse, rat SH3PXD2A
    Clone
    Products:
         
    OriGene clones in human, mouse for SH3PXD2A (see all 7)
    OriGene ORF clones in mouse, rat for SH3PXD2A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SH3PXD2A (NM_014631)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SH3PXD2A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH3PXD2A
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SH3PXD2A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SH3PXD2A
      QuantiTect SYBR Green Assays in human, mouse, rat SH3PXD2A
      QuantiFast Probe-based Assays in human, mouse, rat SH3PXD2A
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-14319 VA6-14241) for SH3PXD2A 

    Selected AceView cDNA sequences (see all 269):

    AW516576 BU162089 D12391 BQ009420 AA376037 W48846 AL603250 BP337958 
    BQ575447 CR608729 AA593302 AU132171 BU167416 BE671178 AI364156 AI417044 
    AA595636 BQ424293 CA431254 BM982064 AW105640 AI095797 AI695815 AI654886 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SH3PXD2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATCTTATAT
    SH3PXD2A Expression
    About this image


    SH3PXD2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
    SH3PXD2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SH3PXD2A Protein Expression

    UniProtKB/Swiss-Prot: SPD2A_HUMAN, Q5TCZ1
    Tissue specificity: Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SH3PXD2A: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Cell Motility in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SH3PXD2A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SH3PXD2A
    QuantiTect SYBR Green Assays in human, mouse, rat SH3PXD2A
    QuantiFast Probe-based Assays in human, mouse, rat SH3PXD2A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3PXD2A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for SH3PXD2A gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sh3pxd2a1 , 5 SH3 and PX domains 2A1, 5 86.89(n)1
    91.61(a)1
      19 (39.45 cM)5
    142181  NM_008018.41  NP_032044.21 
     472601745 
    chicken
    (Gallus gallus)
    Aves SH3PXD2A1 SH3 and PX domains 2A 72.93(n)
    80.15(a)
      423876  XM_004942262.1  XP_004942319.1 
    lizard
    (Anolis carolinensis)
    Reptilia SH3PXD2A6
    SH3 and PX domains 2A
    72(a)
    1 ↔ 1
    3(41004831-41126118)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sh3pxd2a1 SH3 and PX domains 2A 66.82(n)
    71.07(a)
      100489683  XM_004915848.1  XP_004915905.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sh3pxd2aa1 SH3 and PX domains 2Aa 62.99(n)
    64.11(a)
      562018  NM_001160022.1  NP_001153494.1 


    ENSEMBL Gene Tree for SH3PXD2A (if available)
    TreeFam Gene Tree for SH3PXD2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SH3PXD2A gene
    SH3PXD2B2  NOXO12  NCF12  
    Selected SIMAP similar genes for SH3PXD2A using alignment to 5 protein entries:     SPD2A_HUMAN (see all proteins) (see all similar genes):
    RNF217    AGBL3    AURA2    ZNF737    SPATS2L    CTSS
    NF2    NFS1    TMEM14B    LYRM4    C4orf22    TCF4
    ZNF564    TSEN2    UTY    DNAPTP3    FAM175A    GVQW1

    Find genes that share paralogs with SH3PXD2A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SH3PXD2A (see all 4742)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs343112111,2
    C--99059110(+) GAGAG-/AG/GA 
            
    AACGG
    1 -- int10--------
    rs1826624531,2
    --105353459(+) AAATAA/GTAGAA 1 -- ds50010--------
    rs1497007041,2
    --105353529(+) AGGATC/TGCTTG 1 -- ds50010--------
    rs3687740171,2
    C--105353613(+) CCTGT-/AAAAAA 1 -- ds50010--------
    rs352673771,2
    C--105353628(+) AAAAA-/A/AA  
            
    GCGAG
    1 -- ds50011NA 2
    rs1872461711,2
    --105353787(+) CGTTCA/GGTTAA 1 -- ut310--------
    rs1921181641,2
    --105353875(+) CTTACA/GGTCTA 1 -- ut310--------
    rs1831518561,2
    --105354234(+) ATTCTC/TCAAGG 1 -- ut310--------
    rs70849361,2
    C--105354296(+) ATGCTA/CACGCT 1 -- ut310--------
    rs1158240201,2
    C,F--105354330(+) TGCCCG/AGGAGT 1 -- ut311Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for SH3PXD2A (105348285 - 105598285 bp, first 250kb of SH3PXD2A)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SH3PXD2A (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2072570CNV Deletion18987734
    esv1393174CNV Deletion17803354
    esv2740350CNV Deletion23290073
    dgv115e201CNV Deletion23290073
    esv2740362CNV Deletion23290073
    esv2740339CNV Deletion23290073
    esv2740295CNV Deletion23290073
    esv2114347CNV Deletion18987734
    esv2673767CNV Deletion23128226
    esv2740317CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SH3PXD2A
    DNA2.0 Custom Variant and Variant Library Synthesis for SH3PXD2A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus

    Find genes that share disorders with SH3PXD2A           About GenesLikeMe

    Genetic Association Database (GAD): SH3PXD2A
    Human Genome Epidemiology (HuGE) Navigator: SH3PXD2A (3 documents)

    Export disorders for SH3PXD2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SH3PXD2A gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with SH3PXD2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A study of the association between the ADAM12 and SH3PXD2A (SH3MD1) genes and Alzheimer's disease. (PubMed id 19837132)1, 4, 9 Laumet G....Lambert J.C. (Neurosci. Lett. 2010)
    2. Direct interaction between Tks proteins and the N-terminal proline- rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation. (PubMed id 20609497)1, 2 Gianni D.... Bokoch G.M. (Eur. J. Cell Biol. 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M.... Janssen O. (BMC Immunol. 2009)
    5. Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity. (PubMed id 19755710)1, 2 Gianni D....Bokoch G.M. (Sci. Signal. 2009)
    6. A role for the podosome/invadopodia scaffold protein Tks5 in tumor growth in vivo. (PubMed id 18417249)1, 2 Blouw B.... Courtneidge S.A. (Eur. J. Cell Biol. 2008)
    7. The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells. (PubMed id 15710328)1, 2 Seals D.F.... Courtneidge S.A. (Cancer Cell 2005)
    8. Amyloid-beta neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity. (PubMed id 15710903)1, 2 Malinin N.L.... Griswold-Prenner I. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    9. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    10. The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells. (PubMed id 12615925)1, 2 Abram C.L....Courtneidge S.A. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9644 HGNC: 23664 AceView: SH3MD1 Ensembl:ENSG00000107957 euGenes: HUgn9644
    ECgene: SH3PXD2A H-InvDB: SH3PXD2A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0418

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SH3PXD2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SH3PXD2A gene:
    Search GeneIP for patents involving SH3PXD2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of SH3PXD2A
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SH3PXD2A   OriGene RNAi products in human, mouse, rat for SH3PXD2A  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SH3PXD2A  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SH3PXD2A  
     OriGene qSTAR qPCR primer pairs in human, mouse for SH3PXD2A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SH3PXD2A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SH3PXD2A   OriGene Custom Protein Services for SH3PXD2A  

     
     
     Block miRNA regulation of human, mouse, rat SH3PXD2A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SH3PXD2A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SH3PXD2A Predesigned siRNA for gene silencing in human, mouse, rat SH3PXD2A
     QuantiFast Probe-based Assays in human, mouse, rat SH3PXD2A QuantiTect SYBR Green Assays in human, mouse, rat SH3PXD2A
     PCR Arrays including human, mouse, rat SH3PXD2A Search Chromatin IP Primers for SH3PXD2A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SH3PXD2A  GeneGlobe Interaction Network for SH3PXD2A
     Regulatory tfbs in SH3PXD2A promoter
     GenScript Custom Purified and Recombinant Proteins Services for SH3PXD2A GenScript cDNA clones with any tag delivered in your preferred vector for SH3PXD2A
     GenScript Custom Assay Services for SH3PXD2A GenScript Custom overexpressing Cell Line Services for SH3PXD2A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SH3PXD2A (SPD2A)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SH3PXD2A antibodies
     SH3PXD2A lysates
     Search for Antibodies for SH3PXD2A at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SH3PXD2A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SH3PXD2A
     Antibodies for SH3PXD2A
     ELISAs for SH3PXD2A
     CLIAs for SH3PXD2A



     Browse ESI BIO Cell Lines and PureStem Progenitors for SH3PXD2A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3PXD2A
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SH3PXD2A
     SwitchGear Promoter luciferase reporter plasmids for SH3PXD2A
     Search ThermoFisher Antibodies for SH3PXD2A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH3PXD2A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SH3PXD2A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SH3PXD2A
     LSBio Antibodies in human, mouse, rat for SH3PXD2A
     Browse compounds at ApexBio
     Search Addgene for plasmids for SH3PXD2A
      Search eBioscience for proteins for SH3PXD2A
      Search eBioscience for elisas for SH3PXD2A
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for SH3PXD2A (30 products)
     antibodies-online kits for SH3PXD2A (4 products)
     antibodies-online peptides for SH3PXD2A
      Search antibodies-online for proteins for SH3PXD2A
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SH3PXD2A gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4