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Aliases for SH3PXD2A Gene

Aliases for SH3PXD2A Gene

  • SH3 And PX Domains 2A 2 3 5
  • Tyrosine Kinase Substrate With Five SH3 Domains 3 4
  • Five SH3 Domain-Containing Protein 3 4
  • SH3 Multiple Domains 1 2 3
  • Adapter Protein TKS5 3 4
  • SH3MD1 3 4
  • FISH 3 4
  • TKS5 3 4
  • SH3 Multiple Domains Protein 1 4
  • Adaptor Protein TKS5 3
  • Five SH3 Domains 2
  • KIAA0418 4

External Ids for SH3PXD2A Gene

Previous HGNC Symbols for SH3PXD2A Gene

  • SH3MD1

Previous GeneCards Identifiers for SH3PXD2A Gene

  • GC10M105345
  • GC10M098984

Summaries for SH3PXD2A Gene

GeneCards Summary for SH3PXD2A Gene

SH3PXD2A (SH3 And PX Domains 2A) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SH3PXD2B.

UniProtKB/Swiss-Prot for SH3PXD2A Gene

  • Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.

Gene Wiki entry for SH3PXD2A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3PXD2A Gene

Genomics for SH3PXD2A Gene

Regulatory Elements for SH3PXD2A Gene

Promoters for SH3PXD2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SH3PXD2A on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SH3PXD2A gene promoter:

Genomic Location for SH3PXD2A Gene

Chromosome:
10
Start:
103,594,027 bp from pter
End:
103,855,543 bp from pter
Size:
261,517 bases
Orientation:
Minus strand

Genomic View for SH3PXD2A Gene

Genes around SH3PXD2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3PXD2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3PXD2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3PXD2A Gene

Proteins for SH3PXD2A Gene

  • Protein details for SH3PXD2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TCZ1-SPD2A_HUMAN
    Recommended name:
    SH3 and PX domain-containing protein 2A
    Protein Accession:
    Q5TCZ1
    Secondary Accessions:
    • D3DR98
    • O43302
    • Q5TCZ2
    • Q5TDQ8

    Protein attributes for SH3PXD2A Gene

    Size:
    1133 amino acids
    Molecular mass:
    125289 Da
    Quaternary structure:
    • Interacts (via N-terminus) with CYBA (By similarity). Interacts with ADAM12, ADAM15 and ADAM19. Interacts with NOXO1. Interacts (via SH3 domains) with NOXA1. Interacts with FASLG.
    SequenceCaution:
    • Sequence=BAA24848.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SH3PXD2A Gene

    Alternative splice isoforms for SH3PXD2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH3PXD2A Gene

Proteomics data for SH3PXD2A Gene at MOPED

Post-translational modifications for SH3PXD2A Gene

  • Tyrosine phosphorylated by SRC. Phosphorylation plays a regulatory role in the protein localization. The intramolecular interaction of the PX domain with the third SH3 domain maintains the protein in the cytoplasm and phosphorylation disrupts this interaction, resulting in the redistribution of the protein from cytoplasm to the perimembrane region. Phosphorylated on serine upon DNA damage, probably by ATM or ATR.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH3PXD2A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SH3PXD2A Gene

Domains & Families for SH3PXD2A Gene

Protein Domains for SH3PXD2A Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5TCZ1

UniProtKB/Swiss-Prot:

SPD2A_HUMAN :
  • The PX domain is required for podosome localization because of its ability to bind phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and, to a lesser extent, phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Binds to the third intramolecular SH3 domain (By similarity).
  • Belongs to the SH3PXD2 family.
Domain:
  • The PX domain is required for podosome localization because of its ability to bind phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and, to a lesser extent, phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Binds to the third intramolecular SH3 domain (By similarity).
  • The fifth SH3 domain mediates binding with ADAM12, ADAM15 and ADAM19.
  • Contains 1 PX (phox homology) domain.
  • Contains 5 SH3 domains.
Family:
  • Belongs to the SH3PXD2 family.
genes like me logo Genes that share domains with SH3PXD2A: view

No data available for Gene Families for SH3PXD2A Gene

Function for SH3PXD2A Gene

Molecular function for SH3PXD2A Gene

UniProtKB/Swiss-Prot Function:
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.

Gene Ontology (GO) - Molecular Function for SH3PXD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with SH3PXD2A: view
genes like me logo Genes that share phenotypes with SH3PXD2A: view

Animal Models for SH3PXD2A Gene

MGI Knock Outs for SH3PXD2A:

Animal Model Products

  • Taconic Biosciences Mouse Models for SH3PXD2A

CRISPR Products

miRNA for SH3PXD2A Gene

miRTarBase miRNAs that target SH3PXD2A

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SH3PXD2A Gene

Localization for SH3PXD2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH3PXD2A Gene

Cytoplasm. Cell projection, podosome. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SH3PXD2A Gene COMPARTMENTS Subcellular localization image for SH3PXD2A gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SH3PXD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with SH3PXD2A: view

Pathways & Interactions for SH3PXD2A Gene

SuperPathways for SH3PXD2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for SH3PXD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006801 superoxide metabolic process IMP 20609497
genes like me logo Genes that share ontologies with SH3PXD2A: view

No data available for Pathways by source and SIGNOR curated interactions for SH3PXD2A Gene

Drugs & Compounds for SH3PXD2A Gene

No Compound Related Data Available

Transcripts for SH3PXD2A Gene

Unigene Clusters for SH3PXD2A Gene

SH3 and PX domains 2A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3PXD2A Gene

No ASD Table

Relevant External Links for SH3PXD2A Gene

GeneLoc Exon Structure for
SH3PXD2A
ECgene alternative splicing isoforms for
SH3PXD2A

Expression for SH3PXD2A Gene

mRNA expression in normal human tissues for SH3PXD2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SH3PXD2A Gene

This gene is overexpressed in Plasma (19.3), Esophagus (17.5), Tlymphocyte (6.3), and Adrenal (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SH3PXD2A Gene



SOURCE GeneReport for Unigene cluster for SH3PXD2A Gene Hs.678727

mRNA Expression by UniProt/SwissProt for SH3PXD2A Gene

Q5TCZ1-SPD2A_HUMAN
Tissue specificity: Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas.
genes like me logo Genes that share expression patterns with SH3PXD2A: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for SH3PXD2A Gene

Orthologs for SH3PXD2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for SH3PXD2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SH3PXD2A 35
  • 99.1 (n)
  • 99.46 (a)
cow
(Bos Taurus)
Mammalia SH3PXD2A 36
  • 87 (a)
OneToOne
SH3PXD2A 35
  • 90.11 (n)
  • 93.02 (a)
dog
(Canis familiaris)
Mammalia SH3PXD2A 36
  • 90 (a)
OneToOne
SH3PXD2A 35
  • 89.56 (n)
  • 92.4 (a)
mouse
(Mus musculus)
Mammalia Sh3pxd2a 16
Sh3pxd2a 36
  • 89 (a)
OneToOne
Sh3pxd2a 35
  • 86.89 (n)
  • 91.61 (a)
oppossum
(Monodelphis domestica)
Mammalia SH3PXD2A 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SH3PXD2A 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sh3pxd2a 35
  • 86.86 (n)
  • 91.58 (a)
chicken
(Gallus gallus)
Aves SH3PXD2A 36
  • 74 (a)
OneToOne
SH3PXD2A 35
  • 72.93 (n)
  • 80.15 (a)
lizard
(Anolis carolinensis)
Reptilia SH3PXD2A 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3pxd2a 35
  • 66.82 (n)
  • 71.07 (a)
zebrafish
(Danio rerio)
Actinopterygii sh3pxd2ab 36
  • 43 (a)
OneToMany
sh3pxd2aa 36
  • 57 (a)
OneToMany
sh3pxd2aa 35
  • 62.99 (n)
  • 64.11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for SH3PXD2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SH3PXD2A Gene

ENSEMBL:
Gene Tree for SH3PXD2A (if available)
TreeFam:
Gene Tree for SH3PXD2A (if available)

Paralogs for SH3PXD2A Gene

Paralogs for SH3PXD2A Gene

genes like me logo Genes that share paralogs with SH3PXD2A: view

Variants for SH3PXD2A Gene

Sequence variations from dbSNP and Humsavar for SH3PXD2A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs11818820 - 103,603,243(+) TGATT(G/T)GGGGG reference, missense
rs3781365 - 103,602,114(-) CGAAC(A/G)GGCTG reference, missense
rs12764700 - 103,602,000(+) CTTTG(A/G)GGTTA reference, missense
rs762034 -- 103,834,696(-) AGCAA(C/T)GTTAA intron-variant
rs762035 -- 103,833,472(-) TAAAT(A/G)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH3PXD2A Gene

Variant ID Type Subtype PubMed ID
nsv524966 CNV Loss 19592680
nsv895981 CNV Loss 21882294
nsv7530 CNV Insertion 18451855
esv1007127 CNV Loss 20482838
esv2740295 CNV Deletion 23290073
esv2072570 CNV Deletion 18987734
esv2114347 CNV Deletion 18987734
esv1393174 CNV Deletion 17803354
dgv115e201 CNV Deletion 23290073
esv2740317 CNV Deletion 23290073
esv2673767 CNV Deletion 23128226
nsv516106 CNV Loss 19592680
nsv522595 CNV Gain 19592680
nsv518657 CNV Gain 19592680
esv2740339 CNV Deletion 23290073
esv2740350 CNV Deletion 23290073
esv2740362 CNV Deletion 23290073

Variation tolerance for SH3PXD2A Gene

Residual Variation Intolerance Score: 78.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.53; 71.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH3PXD2A Gene

HapMap Linkage Disequilibrium report
SH3PXD2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3PXD2A Gene

Disorders for SH3PXD2A Gene

Relevant External Links for SH3PXD2A

Genetic Association Database (GAD)
SH3PXD2A
Human Genome Epidemiology (HuGE) Navigator
SH3PXD2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SH3PXD2A

No disorders were found for SH3PXD2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3PXD2A Gene

Publications for SH3PXD2A Gene

  1. A study of the association between the ADAM12 and SH3PXD2A (SH3MD1) genes and Alzheimer's disease. (PMID: 19837132) Laumet G. … Lambert J.C. (Neurosci. Lett. 2010) 3 23 48 67
  2. Interaction between the ADAM12 and SH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease. (PMID: 17440933) Harold D. … Williams J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 23
  3. A new method for isolating tyrosine kinase substrates used to identify fish, an SH3 and PX domain-containing protein, and Src substrate. (PMID: 9687503) Lock P. … Courtneidge S.A. (EMBO J. 1998) 2 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for SH3PXD2A Gene

Sources for SH3PXD2A Gene

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