Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SH3KBP1 Gene

protein-coding   GIFtS: 57
GCID: GC0XM019552

SH3-Domain Kinase Binding Protein 1

  See SH3KBP1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
SH3-Domain Kinase Binding Protein 11 2     HSB12
CIN852 3 5     MIG182
Cbl-Interacting Protein Of 85 KDa2 3     C-Cbl-Interacting Protein2
Human Src Family Kinase-Binding Protein 12 3     Migration-Inducing Gene 182
CD2BP32 3     SH3 Domain-Containing Kinase-Binding Protein 12
HSB-12 3     Src Family Kinase-Binding Protein 12
CD2-Binding Protein 32 3     Src-Related Kinase Binding Protein-12
GIG102     

External Ids:    HGNC: 138671   Entrez Gene: 300112   Ensembl: ENSG000001470107   OMIM: 3003745   UniProtKB: Q96B973   

Export aliases for SH3KBP1 gene to outside databases

Previous GC identifers: GC0XM019030 GC0XM018219 GC0XM018751 GC0XM018914 GC0XM019313 GC0XM019462 GC0XM017300


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SH3KBP1 Gene:
This gene encodes an adapter protein that contains three N-terminal Src homology domains, a proline rich region
and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been
implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in
the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript
variants.(provided by RefSeq, May 2010)

GeneCards Summary for SH3KBP1 Gene:
SH3KBP1 (SH3-domain kinase binding protein 1) is a protein-coding gene. Diseases associated with SH3KBP1 include mast-cell leukemia. GO annotations related to this gene include SH3 domain binding. An important paralog of this gene is CD2AP.

UniProtKB/Swiss-Prot: SH3K1_HUMAN, Q96B97
Function: Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation
of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and
MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL,
and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in
regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity
by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion;
promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response
via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor
mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in
the control of cell shape and migration

Gene Wiki entry for SH3KBP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the SH3KBP1 gene promoter:
         Bach1   GCNF   RelA   Nkx2-5   E47   IRF-2   GCNF-1   COMP1   Hand1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SH3KBP1 promoter sequence
   Search Chromatin IP Primers for SH3KBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SH3KBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.1-p21.3   Ensembl cytogenetic band:  Xp22.12   HGNC cytogenetic band: Xp22.1-p21.3

SH3KBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SH3KBP1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM019552:  view genomic region     (about GC identifiers)

Start:
19,552,083 bp from pter      End:
19,905,744 bp from pter
Size:
353,662 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SH3K1_HUMAN, Q96B97 (See protein sequence)
Recommended Name: SH3 domain-containing kinase-binding protein 1  
Size: 665 amino acids; 73126 Da
Subunit: Can self-associate and form homotetramers. Interacts with CD2, F-actin capping protein, PIK3R3, GRB2,
EGFR, MET, BLNK, MAP3K4, PDCD6IP, SPRY2, ARHGAP17, ARHGAP27, MAGI2, CRK, BCAR1, SOS1, ASAP1, ARAP3, HIP1R, SYNJ2,
INPP5D and STAP1. Interacts with CBL and CBLB, but does not interact with CBLC. Two molecules of SH3KBP1 seem to
bind through their respective SH3 1 domain to one molecule of CBLB. The interaction with CBL or CBLB and EGFR is
increased upon EGF stimulation. The interaction with CBL is attenuated by PDCD6IP. Interacts through its
proline-rich region with the SH3 domain of endophilins SH3GL1, SH3GL2 and SH3GL3. The SH3KBP1-endophilin complex
seems to associate with a complex containing the phosphorylated receptor (EGFR or MET) and phosphorylated CBL.
Probably associates with ASAP1 and phosphorylated EGFR. Probably part of a complex consisting of at least
SH3KBP1, ASAP1 and ARAP3. Interacts with focal adhesion kinases PTK2/FAK1 AND PTK2B/PYK2, probably as a dimer.
Interacts with DAB2 and probably associates with chathrin through its interaction with DAB2. Part of a complex
consisting of SH3KBP1, DAB2, and clathrin heavy chain. DAB2 and clathrin dissociate from SH3KBP1 following growth
factor treatment, enabling interaction with CBL. Interacts with DDN and probably associates with MAGI2 through
its interaction with DDN. Interacts with the SH3 domains of SRC tyrosine-protein kinases SRC, LCK, LYN, FGR, FYN
and HCK. Interacts with TRADD, BIRC2, TRAF1, TRAF2 and TNFR1, and the association with a TNFR1-associated complex
upon stimulation with TNF-alpha seems to be mediated by SRC. Probably interacts with SH3KBP1
Sequence caution: Sequence=AAH50663.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
5 PDB 3D structures from and Proteopedia for SH3KBP1:
2BZ8 (3D)        2K6D (3D)        2K9G (3D)        2O2O (3D)        2YDL (3D)    
Secondary accessions: B7Z1D5 Q5JPT4 Q5JPT5 Q8IWX6 Q8IX98 Q96RN4 Q9NYR0
Alternative splicing: 3 isoforms:  Q96B97-1   Q96B97-2   Q96B97-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SH3KBP1: NX_Q96B97

Explore proteomics data for SH3KBP1 at MOPED

Post-translational modifications: 

  • Monoubiquitinated by CBL and CBLB after EGF stimulation; probably on its C-terminus1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SH3KBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001019837.1  NP_001171889.1  NP_114098.1  

    ENSEMBL proteins: 
     ENSP00000380921   ENSP00000369039   ENSP00000369020   ENSP00000369049   ENSP00000369019  
     ENSP00000388766   ENSP00000409292   ENSP00000442499  
    Reactome Protein details: Q96B97

    SH3KBP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for SH3KBP1
    OriGene Protein Over-expression Lysate for SH3KBP1
    OriGene MassSpec for SH3KBP1
    OriGene Custom Protein Services for SH3KBP1
    GenScript Custom Purified and Recombinant Proteins Services for SH3KBP1
    Novus Biologicals SH3KBP1 Proteins
    Novus Biologicals SH3KBP1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SH3KBP1

     
    Search eBioscience for Proteins for SH3KBP1 

     
    antibodies-online proteins for SH3KBP1 (7 products) 

     
    antibodies-online peptides for SH3KBP1

    SH3KBP1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SH3KBP1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for SH3KBP1  (CIN85)
    OriGene Antibodies for SH3KBP1
    OriGene Custom Antibody Services for SH3KBP1
    Novus Biologicals SH3KBP1 Antibodies
    Abcam antibodies for SH3KBP1
    Cloud-Clone Corp. Antibodies for SH3KBP1
    Search ThermoFisher Antibodies for SH3KBP1
    antibodies-online antibodies for SH3KBP1 (41 products) 

    SH3KBP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SH3KBP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SH3KBP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SH3KBP1
    Cloud-Clone Corp. CLIAs for SH3KBP1
    Search eBioscience for ELISAs for SH3KBP1 
    antibodies-online kits for SH3KBP1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q96B97

    ProtoNet protein and cluster: Q96B97

    UniProtKB/Swiss-Prot: SH3K1_HUMAN, Q96B97
    Domain: The SH3 domains mediate interaction with SHKBP1 (By similarity)
    Similarity: Contains 3 SH3 domains


    Find genes that share domains with SH3KBP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SH3K1_HUMAN, Q96B97
    Function: Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation
    of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and
    MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL,
    and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in
    regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity
    by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion;
    promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response
    via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor
    mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in
    the control of cell shape and migration

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10679202
    GO:0016301kinase activity ----
    GO:0017124SH3 domain binding IEA--
         
    Find genes that share ontologies with SH3KBP1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SH3KBP1:
     Decreased number of cells in m  Increased cilium length after  

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sh3kbp1):
     adipose tissue  behavior/neurological  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  nervous system  other 

    Find genes that share phenotypes with SH3KBP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sh3kbp1tm1Ivdi for SH3KBP1

       genOway: Develop your customized and physiologically relevant rodent model for SH3KBP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SH3KBP1:
    hsa-mir-1914-5p (MIRT035790)

    Block miRNA regulation of human, mouse, rat SH3KBP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SH3KBP1 (see all 75):
    hsa-miR-411* hsa-miR-579 hsa-miR-100* hsa-miR-30d hsa-miR-30a hsa-miR-629 hsa-miR-3613-3p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidSH3KBP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SH3KBP1
    Predesigned siRNA for gene silencing in human, mouse, rat SH3KBP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SH3KBP1

    Clone
    Products:
         
    OriGene clones in human, mouse for SH3KBP1 (see all 20)
    OriGene ORF clones in mouse, rat for SH3KBP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SH3KBP1 (NM_031892)
    Sino Biological Human cDNA Clone for SH3KBP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SH3KBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH3KBP1
    Addgene plasmids for SH3KBP1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SH3KBP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SH3KBP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3KBP1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11982) for SH3KBP1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SH3K1_HUMAN, Q96B97: Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cell
    junction, synapse, synaptosome. Cell junction, focal adhesion (By similarity). Note=Localized in endocytic
    vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin
    microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    plasma membrane4
    nucleus3
    endosome2
    lysosome2
    vacuole2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IEA--
    GO:0005886plasma membrane TAS--
    GO:0005925focal adhesion IEA--
    GO:0030659cytoplasmic vesicle membrane IEA--

    Find genes that share ontologies with SH3KBP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SH3KBP1 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR
    Signaling by EGFR0.83
    Signaling by EGFR in Cancer0.82
    2Downstream Signaling Events Of B Cell Receptor (BCR)
    Signaling by the B Cell Receptor (BCR)0.79
    3Signaling by GPCR
    Signal Transduction0.58
    4Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
    Antigen Activates B Cell Receptor Leading to Generation of Second Messengers0.47
    5Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41


    Find genes that share SuperPaths with SH3KBP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 Cell Signaling Technology (CST) Pathways for SH3KBP1
        Cytoskeletal Signaling
    Lymphocyte Signaling
    Tyrosine Kinases / Adaptors
    Protein Stability

    4 BioSystems Pathways for SH3KBP1
        EGFR1 Signaling Pathway
    Kit Receptor Signaling Pathway
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    Internalization of ErbB1


    2 Reactome Pathways for SH3KBP1
        Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
    EGFR downregulation


    1 Kegg Pathway  (Kegg details for SH3KBP1):
        Endocytosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SH3KBP1
    Interactions:

        GeneGlobe Interaction Network for SH3KBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SH3KBP1 (Q96B971, 2, 3 ENSP000003809214) via UniProtKB, MINT, STRING, and/or I2D (see all 250)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBLBQ131911, 2, 3, ENSP000002641224EBI-346595,EBI-744027 MINT-7218365 MINT-6170377 MINT-6170285 MINT-60962 MINT-6170307 MINT-6170329 MINT-7218592 MINT-7218322 MINT-6170347 MINT-7218288 MINT-7218378 MINT-60960 MINT-60961 MINT-7218305 I2D: score=3 STRING: ENSP00000264122
    ASAP1Q9ULH11, 2, 3, ENSP000003502974EBI-346595,EBI-346622 MINT-8109719 MINT-4299861 MINT-8109706 MINT-4299822 MINT-8109732 MINT-4299909 MINT-4300027 MINT-4299808 I2D: score=3 STRING: ENSP00000350297
    SH3BP2P783141, 2, 3, ENSP000003486854EBI-346595,EBI-727062 MINT-4550212 MINT-4563320 MINT-4563239 MINT-4563367 MINT-4563210 MINT-4551264 MINT-4549116 MINT-4551452 I2D: score=2 STRING: ENSP00000348685
    CBLP226811, 2, 3, ENSP000002640334EBI-346595,EBI-518228 MINT-6170185 MINT-6170213 MINT-16164 MINT-6170363 MINT-6170454 MINT-6170575 MINT-7218338 MINT-6170167 MINT-7211898 MINT-16165 MINT-6170624 MINT-8058594 MINT-7218251 MINT-7211942 MINT-6170443 MINT-6170405 MINT-6170469 MINT-6170229 MINT-16163 MINT-7218234 MINT-7218352 MINT-6170490 MINT-6170430 MINT-7218271 I2D: score=5 STRING: ENSP00000264033
    DNM2P505701, 2, 3, ENSP000003527214EBI-346595,EBI-346547 MINT-8045136 MINT-8058429 MINT-8058579 MINT-8058474 MINT-8058455 MINT-8045165 I2D: score=3 STRING: ENSP00000352721
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0006915apoptotic process IEA--
    GO:0007010cytoskeleton organization IMP--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007267cell-cell signaling NAS10679202

    Find genes that share ontologies with SH3KBP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SH3KBP1 (SH3K1)

    2 Novoseek inferred chemical compound relationships for SH3KBP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 51.6 12 12874286 (2), 17675467 (2), 14596919 (2), 12218189 (1) (see all 9)
    phosphatidylinositol 19.2 1 15707590 (1)



    Find genes that share compounds with SH3KBP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SH3KBP1 gene (3 alternative transcripts): 
    NM_001024666.2  NM_001184960.1  NM_031892.2  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397821(uc010nfm.3 uc011mje.2 uc004czl.3 uc004czm.3)
    ENST00000379716(uc011mjf.2) ENST00000379698 ENST00000379726 ENST00000379697
    ENST00000494961 ENST00000477102 ENST00000432234 ENST00000431164 ENST00000541422

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SH3KBP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SH3KBP1 (see all 75):
    hsa-miR-411* hsa-miR-579 hsa-miR-100* hsa-miR-30d hsa-miR-30a hsa-miR-629 hsa-miR-3613-3p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidSH3KBP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SH3KBP1
    Predesigned siRNA for gene silencing in human, mouse, rat SH3KBP1
    Clone
    Products:
         
    OriGene clones in human, mouse for SH3KBP1 (see all 20)
    OriGene ORF clones in mouse, rat for SH3KBP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SH3KBP1 (NM_031892)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SH3KBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH3KBP1
    Addgene plasmids for SH3KBP1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SH3KBP1
    OriGene qSTAR qPCR primer pairs in human, mouse for SH3KBP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SH3KBP1
      QuantiTect SYBR Green Assays in human, mouse, rat SH3KBP1
      QuantiFast Probe-based Assays in human, mouse, rat SH3KBP1
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11982) for SH3KBP1 

    Selected AceView cDNA sequences (see all 278):

    BE550695 AW316519 BE395779 BM726728 BQ061647 AI678872 AI631313 BQ049542 
    NM_031892 BQ061055 AA649136 BQ437471 BQ214000 AA872966 AF329267 AA651852 
    AA687232 BU509384 AA476734 BM907590 BQ066324 N93561 AI363058 CB118975 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SH3KBP1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20 ^ 21
    SP1:              -     -                             -                                         -                                                         
    SP2:                    -                             -                                         -                                                         
    SP3:                                                                                                                                                      
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for SH3KBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SH3KBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SH3KBP1 Expression
    About this image


    SH3KBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Lymph (Hematopoietic System)
    SH3KBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SH3KBP1 Protein Expression

    UniProtKB/Swiss-Prot: SH3K1_HUMAN, Q96B97
    Tissue specificity: Ubiquitously expressed. Also expressed in some cancer cell lines

        Custom PCR Arrays for SH3KBP1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SH3KBP1
    OriGene qSTAR qPCR primer pairs in human, mouse for SH3KBP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SH3KBP1
    QuantiTect SYBR Green Assays in human, mouse, rat SH3KBP1
    QuantiFast Probe-based Assays in human, mouse, rat SH3KBP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3KBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SH3KBP1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sh3kbp11 , 5 SH3-domain kinase binding protein 11, 5 90.93(n)1
    94.14(a)1
      X (73.65 cM)5
    581941  NM_001135727.11  NP_001129199.11 
     1596272725 
    chicken
    (Gallus gallus)
    Aves SH3KBP11 SH3-domain kinase binding protein 1 76.05(n)
    79(a)
      418608  NM_001030805.1  NP_001025976.1 
    lizard
    (Anolis carolinensis)
    Reptilia SH3KBP16
    SH3-domain kinase binding protein 1
    67(a)
    1 ↔ 1
    3(123532775-123770742)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.90672 Transcribed sequence with weak similarity to protein more 73.29(n)    CF784459.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sh3kbp11 SH3-domain kinase binding protein 1 62.3(n)
    59.71(a)
      793623  XM_002666661.3  XP_002666707.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta cindr6
    CIN85 and CD2AP orthologue
    15(a)
    1 → many
    3R(26634338-26652722)
    worm
    (Caenorhabditis elegans)
    Secernentea Y44E3A.46
    Protein Y44E3A.4 (Y44E3A.4) mRNA, complete cds
    22(a)
    1 → many
    I(3319853-3330673) WBGene00021549


    ENSEMBL Gene Tree for SH3KBP1 (if available)
    TreeFam Gene Tree for SH3KBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SH3KBP1 gene
    CD2AP2  SH3D212  
    6 SIMAP similar genes for SH3KBP1 using alignment to 7 protein entries:     SH3K1_HUMAN (see all proteins):
    ARHGEF7    SH3GL2    NOSTRIN    SH3GL1    ITSN1    CD2AP

    Find genes that share paralogs with SH3KBP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SH3KBP1 (see all 4310)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1857176571,2
    --19465503(+) ACCTAA/CCTGGC 3 -- ds50010--------
    rs1894609001,2
    --19465976(+) GTAGCA/GGCTCG 3 -- ut310--------
    rs1809699671,2
    --19466173(+) CAACCA/GCTCAA 3 -- ut310--------
    rs1859030381,2
    --19466775(+) TCAGGA/GAAGAG 3 -- ut310--------
    rs1924247381,2
    --19466810(+) TCCAAC/TATCTT 3 -- ut310--------
    rs1832334461,2
    --19467120(+) TTAAAC/TGATAA 3 -- ut310--------
    rs1511862211,2
    --19467203(+) TTTATC/TTTTGC 3 -- ut310--------
    rs1860321281,2
    --19467230(+) CTGTTC/TACGCA 3 -- ut310--------
    rs2004862121,2
    C--19467233(-) TTTTGC/TGTGAA 3 -- ut310--------
    rs74733151,2
    H--19467534(+) GTGGTA/TAAAAG 3 -- ut31 ese3 trp34Minor allele frequency- T:0.00NS EA 418

    HapMap Linkage Disequilibrium report for SH3KBP1 (19552083 - 19802083 bp, first 250kb of SH3KBP1)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SH3KBP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6825CNV Insertion18451855
    nsv6826CNV Insertion18451855
    nsv6824CNV Loss18451855

    Locus Specific Mutation Databases (LSDB): SH3KBP1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SH3KBP1
    DNA2.0 Custom Variant and Variant Library Synthesis for SH3KBP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 300374    OMIM disorders: --

    1 disease for SH3KBP1:    
    About MalaCards
    mast-cell leukemia

    1 disease from the University of Copenhagen DISEASES database for SH3KBP1:
    mast-cell leukemia

    Find genes that share disorders with SH3KBP1           About GenesLikeMe

    1 Novoseek inferred disease relationship for SH3KBP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 12177062 (1)


    Export disorders for SH3KBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SH3KBP1 gene, integrated from 10 sources (see all 122):
    (articles sorted by number of sources associating them with SH3KBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CD2BP3, CIN85 and the structurally related adaptor protein CMS bind to the same CD2 cytoplasmic segment but elicit divergent functional activities. (PubMed id 12618476)1, 2, 9 Tibaldi E.V. and Reinherz E.L. (Int. Immunol. 2003)
    2. Dab2 links CIN85 with clathrin-mediated receptor internalization. (PubMed id 14596919)1, 2, 9 Kowanetz K.... Dikic I. (FEBS Lett. 2003)
    3. CIN85 associates with TNF receptor 1 via Src and modulates TNF-alpha- induced apoptosis. (PubMed id 15707590)1, 2, 9 Narita T.... Taniyama T. (Exp. Cell Res. 2005)
    4. CIN85 regulates the ability of MEKK4 to activate the p38 MAP kinase pathway. (PubMed id 16256071)1, 2, 9 Aissouni Y.... Soubeyran P. (Biochem. Biophys. Res. Commun. 2005)
    5. Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl. (PubMed id 10679202)1, 2, 9 Take H.... Kajigaya S. (Biochem. Biophys. Res. Commun. 2000)
    6. Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors. (PubMed id 12218189)1, 2, 9 Haglund K.... Dikic I. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors. (PubMed id 15090612)1, 2, 9 Kowanetz K....Dikic I. (Mol. Biol. Cell 2004)
    8. CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases. (PubMed id 12177062)1, 2, 9 Szymkiewicz I....Dikic I. (J. Biol. Chem. 2002)
    9. Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85. (PubMed id 12690097)1, 2, 9 Hutchings N.J.... Brown M.H. (J. Biol. Chem. 2003)
    10. Cbl promotes clustering of endocytic adaptor proteins. (PubMed id 16228008)1, 2, 9 Jozic D.... Bravo J. (Nat. Struct. Mol. Biol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 30011 HGNC: 13867 AceView: SH3KBP1 Ensembl:ENSG00000147010 euGenes: HUgn30011
    ECgene: SH3KBP1 Kegg: 30011 H-InvDB: SH3KBP1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SH3KBP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SH3KBP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SH3KBP1 gene:
    Search GeneIP for patents involving SH3KBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SH3KBP1
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SH3KBP1   OriGene RNAi products in human, mouse, rat for SH3KBP1  
     OriGene qPCR primer pairs and template standards for SH3KBP1   OriGene Protein Over-expression Lysate for SH3KBP1  
     OriGene MassSpec for SH3KBP1   OriGene clones in human, mouse for SH3KBP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SH3KBP1   OriGene Purified Protein for SH3KBP1  
     OriGene ORF clones in mouse, rat for SH3KBP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SH3KBP1   OriGene Custom Protein Services for SH3KBP1  

     
     
     Block miRNA regulation of human, mouse, rat SH3KBP1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SH3KBP1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SH3KBP1 Predesigned siRNA for gene silencing in human, mouse, rat SH3KBP1
     QuantiFast Probe-based Assays in human, mouse, rat SH3KBP1 QuantiTect SYBR Green Assays in human, mouse, rat SH3KBP1
     Custom PCR Arrays for SH3KBP1 Search Chromatin IP Primers for SH3KBP1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SH3KBP1  GeneGlobe Interaction Network for SH3KBP1
     Regulatory tfbs in SH3KBP1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SH3KBP1 GenScript cDNA clones with any tag delivered in your preferred vector for SH3KBP1
     GenScript Custom Assay Services for SH3KBP1 GenScript Custom overexpressing Cell Line Services for SH3KBP1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for SH3KBP1  (CIN85)

     Search Tocris compounds for SH3KBP1 (SH3K1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for SH3KBP1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SH3KBP1 antibodies
     SH3KBP1 proteins
     SH3KBP1 lysates
     Antibodies for SH3KBP1
     See all of Abcam's Antibodies, Kits and Proteins for SH3KBP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SH3KBP1
     Antibodies for SH3KBP1
     ELISAs for SH3KBP1
     CLIAs for SH3KBP1



     Browse ESI BIO Cell Lines and PureStem Progenitors for SH3KBP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3KBP1
     SwitchGear 3'UTR luciferase reporter plasmids for SH3KBP1
     SwitchGear Promoter luciferase reporter plasmids for SH3KBP1
     Search ThermoFisher Antibodies for SH3KBP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH3KBP1
     Browse compounds at ApexBio
     Addgene plasmids for SH3KBP1
      Search eBioscience for proteins for SH3KBP1
      Search eBioscience for elisas for SH3KBP1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for SH3KBP1
     antibodies-online antibodies for SH3KBP1 (41 products)
     antibodies-online kits for SH3KBP1 (6 products)
     antibodies-online peptides for SH3KBP1
     antibodies-online proteins for SH3KBP1 (7 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SH3KBP1 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4