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Aliases for SH3KBP1 Gene

Aliases for SH3KBP1 Gene

  • SH3 Domain Containing Kinase Binding Protein 1 2 3 5
  • Human Src Family Kinase-Binding Protein 1 3 4
  • Cbl-Interacting Protein Of 85 KDa 3 4
  • CD2-Binding Protein 3 3 4
  • CD2BP3 3 4
  • CIN85 3 4
  • HSB-1 3 4
  • SH3 Domain-Containing Kinase-Binding Protein 1 3
  • Src-Related Kinase Binding Protein-1 3
  • SH3-Domain Kinase Binding Protein 1 3
  • Src Family Kinase-Binding Protein 1 3
  • Migration-Inducing Gene 18 3
  • C-Cbl-Interacting Protein 3
  • GIG10 3
  • MIG18 3
  • HSB1 3

External Ids for SH3KBP1 Gene

Previous GeneCards Identifiers for SH3KBP1 Gene

  • GC0XM019030
  • GC0XM018219
  • GC0XM018751
  • GC0XM018914
  • GC0XM019313
  • GC0XM019462
  • GC0XM017300

Summaries for SH3KBP1 Gene

Entrez Gene Summary for SH3KBP1 Gene

  • This gene encodes an adapter protein that contains three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

GeneCards Summary for SH3KBP1 Gene

SH3KBP1 (SH3 Domain Containing Kinase Binding Protein 1) is a Protein Coding gene. Diseases associated with SH3KBP1 include Adrenal Cortical Adenocarcinoma. Among its related pathways are Lipoprotein metabolism and Innate Immune System. GO annotations related to this gene include SH3 domain binding. An important paralog of this gene is CD2AP.

UniProtKB/Swiss-Prot for SH3KBP1 Gene

  • Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration.

Gene Wiki entry for SH3KBP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3KBP1 Gene

Genomics for SH3KBP1 Gene

Regulatory Elements for SH3KBP1 Gene

Enhancers for SH3KBP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG019742 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19 +140.6 140581 8.8 PKNOX1 TBL1XR1 WRNIP1 RAD21 RELB ETV6 IKZF2 CREM ZNF280D CBFB SH3KBP1 CXorf23 GC0XP019714
GH0XG019771 1.6 FANTOM5 Ensembl ENCODE dbSUPER 19.1 +113.1 113057 7.1 HDGF PKNOX1 ZSCAN4 YBX1 EBF1 RELA ZFHX2 GATA2 EED SCRT2 SH3KBP1 CXorf23 MAP7D2 RPS6KA3 GC0XP019714
GH0XG019681 1.5 FANTOM5 Ensembl ENCODE 18.4 +204.4 204368 3.4 INSM2 BMI1 FEZF1 SCRT2 FOS RELB IKZF2 EGR2 ZNF362 CEBPB SH3KBP1 CXorf23 GC0XP019714 MAP3K15
GH0XG019796 1.5 FANTOM5 Ensembl ENCODE dbSUPER 17.2 +88.7 88675 5.6 CTCF BHLHE40 TRIM22 ZNF623 ZIC2 RAD21 POLR2A NFYB NR2C1 KDM1A SH3KBP1 RPS6KA3 GC0XP019714
GH0XG019758 1.4 Ensembl ENCODE dbSUPER 18 +128.1 128144 2.2 PKNOX1 ZSCAN4 INSM2 FEZF1 BMI1 ZNF2 ZNF366 KLF7 FOS RELB SH3KBP1 CXorf23 GC0XP019714
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SH3KBP1 on UCSC Golden Path with GeneCards custom track

Promoters for SH3KBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000245090 226 2801 FOXA2 DMAP1 ZNF2 ZNF121 GLIS2 ZNF143 ZNF263 SP3 REST PPARG

Genomic Location for SH3KBP1 Gene

Chromosome:
X
Start:
19,533,965 bp from pter
End:
19,887,626 bp from pter
Size:
353,662 bases
Orientation:
Minus strand

Genomic View for SH3KBP1 Gene

Genes around SH3KBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3KBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3KBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3KBP1 Gene

Proteins for SH3KBP1 Gene

  • Protein details for SH3KBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B97-SH3K1_HUMAN
    Recommended name:
    SH3 domain-containing kinase-binding protein 1
    Protein Accession:
    Q96B97
    Secondary Accessions:
    • B7Z1D5
    • Q5JPT4
    • Q5JPT5
    • Q8IWX6
    • Q8IX98
    • Q96RN4
    • Q9NYR0

    Protein attributes for SH3KBP1 Gene

    Size:
    665 amino acids
    Molecular mass:
    73126 Da
    Quaternary structure:
    • Can self-associate and form homotetramers. Interacts with CD2, F-actin capping protein, PIK3R3, GRB2, EGFR, MET, BLNK, MAP3K4, PDCD6IP, SPRY2, ARHGAP17, ARHGAP27, MAGI2, CRK, BCAR1, SOS1, ASAP1, ARAP3, HIP1R, SYNJ2, INPP5D and STAP1. Interacts with CBL and CBLB, but does not interact with CBLC. Two molecules of SH3KBP1 seem to bind through their respective SH3 1 domain to one molecule of CBLB. The interaction with CBL or CBLB and EGFR is increased upon EGF stimulation. The interaction with CBL is attenuated by PDCD6IP. Interacts through its proline-rich region with the SH3 domain of endophilins SH3GL1, SH3GL2 and SH3GL3. The SH3KBP1-endophilin complex seems to associate with a complex containing the phosphorylated receptor (EGFR or MET) and phosphorylated CBL. Probably associates with ASAP1 and phosphorylated EGFR. Probably part of a complex consisting of at least SH3KBP1, ASAP1 and ARAP3. Interacts with focal adhesion kinases PTK2/FAK1 AND PTK2B/PYK2, probably as a dimer. Interacts with DAB2 and probably associates with chathrin through its interaction with DAB2. Part of a complex consisting of SH3KBP1, DAB2, and clathrin heavy chain. DAB2 and clathrin dissociate from SH3KBP1 following growth factor treatment, enabling interaction with CBL. Interacts with DDN and probably associates with MAGI2 through its interaction with DDN. Interacts with the SH3 domains of SRC tyrosine-protein kinases SRC, LCK, LYN, FGR, FYN and HCK. Interacts with TRADD, BIRC2, TRAF1, TRAF2 and TNFR1, and the association with a TNFR1-associated complex upon stimulation with TNF-alpha seems to be mediated by SRC. Interacts (via SH3 domains) with SHKBP1 (via PXXXPR motifs) (By similarity). Interaction with CBL is abolished in the presence of SHKBP1 (By similarity). Interacts (via SH3 domains) with ZFP36 (via extreme C-terminal region) (PubMed:20221403). Interacts with MAP3K4; this interaction enhances the association with ZFP36 (PubMed:20221403).
    SequenceCaution:
    • Sequence=AAH50663.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SH3KBP1 Gene

    Alternative splice isoforms for SH3KBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH3KBP1 Gene

Post-translational modifications for SH3KBP1 Gene

  • Monoubiquitinated by CBL and CBLB after EGF stimulation; probably on its C-terminus.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for SH3KBP1 (CIN85/SH3KBP1)
  • Cell Signaling Technology (CST) Antibodies for SH3KBP1 (SH3KBP1)

No data available for DME Specific Peptides for SH3KBP1 Gene

Domains & Families for SH3KBP1 Gene

No data available for Gene Families and UniProtKB/Swiss-Prot for SH3KBP1 Gene

Function for SH3KBP1 Gene

Molecular function for SH3KBP1 Gene

UniProtKB/Swiss-Prot Function:
Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration.

Gene Ontology (GO) - Molecular Function for SH3KBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10679202
GO:0016301 kinase activity IEA --
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with SH3KBP1: view
genes like me logo Genes that share phenotypes with SH3KBP1: view

Animal Models for SH3KBP1 Gene

MGI Knock Outs for SH3KBP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SH3KBP1 Gene

Localization for SH3KBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH3KBP1 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Cell junction, focal adhesion. Note=Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes. Translocation to EGFR containing vesicles upon EGF stimulation is inhibited in the presence of SH3KBP1 (By similarity). Colocalizes with ZFP36 in the cytoplasm (PubMed:20221403). {ECO:0000250 UniProtKB:Q8R550, ECO:0000269 PubMed:20221403}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH3KBP1 gene
Compartment Confidence
plasma membrane 5
cytosol 5
cytoskeleton 4
nucleus 3
lysosome 2
endosome 2

Gene Ontology (GO) - Cellular Components for SH3KBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IEA 20221403
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction IEA --
genes like me logo Genes that share ontologies with SH3KBP1: view

Pathways & Interactions for SH3KBP1 Gene

genes like me logo Genes that share pathways with SH3KBP1: view

Interacting Proteins for SH3KBP1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000380921%0d%0a9606.ENSP00000248070%0d%0a9606.ENSP00000221972%0d%0a9606.ENSP00000222390%0d%0a9606.ENSP00000263904%0d%0a9606.ENSP00000314458%0d%0a
Selected Interacting proteins: ENSP00000380921 Q96B97-SH3K1_HUMAN for SH3KBP1 Gene via STRING MINT IID UniProtKB

Symbol External ID(s) Details
CBLB
CBL
ASAP1
SH3BP2
INPP5D

SIGNOR curated interactions for SH3KBP1 Gene

Activates:

Gene Ontology (GO) - Biological Process for SH3KBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0006915 apoptotic process IEA --
GO:0007010 cytoskeleton organization IMP 21834987
GO:0007267 cell-cell signaling NAS 10679202
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with SH3KBP1: view

Drugs & Compounds for SH3KBP1 Gene

(1) Drugs for SH3KBP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SH3KBP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SH3KBP1: view

Transcripts for SH3KBP1 Gene

Unigene Clusters for SH3KBP1 Gene

SH3-domain kinase binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3KBP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20 ^ 21
SP1: - - - -
SP2: - - -
SP3:
SP4:
SP5:
SP6: -

Relevant External Links for SH3KBP1 Gene

GeneLoc Exon Structure for
SH3KBP1
ECgene alternative splicing isoforms for
SH3KBP1

Expression for SH3KBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SH3KBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH3KBP1 Gene

This gene is overexpressed in Whole Blood (x6.4).

Protein differential expression in normal tissues from HIPED for SH3KBP1 Gene

This gene is overexpressed in Lymph node (20.9), Peripheral blood mononuclear cells (16.8), and Tlymphocyte (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SH3KBP1 Gene



Protein tissue co-expression partners for SH3KBP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SH3KBP1 Gene:

SH3KBP1

SOURCE GeneReport for Unigene cluster for SH3KBP1 Gene:

Hs.726365

mRNA Expression by UniProt/SwissProt for SH3KBP1 Gene:

Q96B97-SH3K1_HUMAN
Tissue specificity: Ubiquitously expressed. Also expressed in some cancer cell lines.

Evidence on tissue expression from TISSUES for SH3KBP1 Gene

  • Blood(4.4)
  • Adrenal gland(4.2)
  • Liver(4.2)
  • Nervous system(3.8)
  • Lung(2.3)
  • Lymph node(2)
  • Skin(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with SH3KBP1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SH3KBP1 Gene

Orthologs for SH3KBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3KBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SH3KBP1 34
  • 93.6 (n)
dog
(Canis familiaris)
Mammalia SH3KBP1 34 35
  • 92.42 (n)
cow
(Bos Taurus)
Mammalia SH3KBP1 34 35
  • 91.28 (n)
mouse
(Mus musculus)
Mammalia Sh3kbp1 34 16 35
  • 90.93 (n)
rat
(Rattus norvegicus)
Mammalia Sh3kbp1 34
  • 90.38 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 86 (a)
OneToMany
-- 35
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SH3KBP1 35
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves SH3KBP1 34 35
  • 76.05 (n)
lizard
(Anolis carolinensis)
Reptilia SH3KBP1 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3kbp1 34
  • 68.2 (n)
Str.9067 34
zebrafish
(Danio rerio)
Actinopterygii sh3kbp1 34 35
  • 62.3 (n)
fruit fly
(Drosophila melanogaster)
Insecta cindr 35
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y44E3A.4 35
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
OneToMany
Species where no ortholog for SH3KBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3KBP1 Gene

ENSEMBL:
Gene Tree for SH3KBP1 (if available)
TreeFam:
Gene Tree for SH3KBP1 (if available)

Paralogs for SH3KBP1 Gene

Paralogs for SH3KBP1 Gene

(6) SIMAP similar genes for SH3KBP1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SH3KBP1: view

Variants for SH3KBP1 Gene

Sequence variations from dbSNP and Humsavar for SH3KBP1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs483352756 Uncertain significance 19,588,683(-) CCCCG(A/G)GAAGG reference, missense
rs1000005192 -- 19,839,958(+) TCAAG(G/T)GTCAA intron-variant
rs1000022578 -- 19,661,773(+) AGGCA(C/T)GCGCC intron-variant
rs1000034956 -- 19,886,211(+) GACTG(A/G)GTTAA intron-variant
rs1000037922 -- 19,802,714(+) TTCCT(C/G)TTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH3KBP1 Gene

Variant ID Type Subtype PubMed ID
dgv2232e212 CNV loss 25503493
nsv477053 CNV novel sequence insertion 20440878
nsv6824 CNV deletion 18451855
nsv6825 CNV insertion 18451855
nsv6826 CNV insertion 18451855

Variation tolerance for SH3KBP1 Gene

Residual Variation Intolerance Score: 9.91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH3KBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SH3KBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3KBP1 Gene

Disorders for SH3KBP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SH3KBP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
adrenal cortical adenocarcinoma
  • adrenocortical carcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SH3KBP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SH3KBP1
genes like me logo Genes that share disorders with SH3KBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SH3KBP1 Gene

Publications for SH3KBP1 Gene

  1. Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85. (PMID: 20221403) Kedar V.P. … Blackshear P.J. (PLoS ONE 2010) 3 4 22 64
  2. CIN85 associates with TNF receptor 1 via Src and modulates TNF-alpha- induced apoptosis. (PMID: 15707590) Narita T. … Taniyama T. (Exp. Cell Res. 2005) 3 4 22 64
  3. Cbl promotes clustering of endocytic adaptor proteins. (PMID: 16228008) Jozic D. … Bravo J. (Nat. Struct. Mol. Biol. 2005) 3 4 22 64
  4. CIN85 regulates the ability of MEKK4 to activate the p38 MAP kinase pathway. (PMID: 16256071) Aissouni Y. … Soubeyran P. (Biochem. Biophys. Res. Commun. 2005) 3 4 22 64
  5. CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors. (PMID: 15090612) Kowanetz K. … Dikic I. (Mol. Biol. Cell 2004) 3 4 22 64

Products for SH3KBP1 Gene

Sources for SH3KBP1 Gene

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