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Aliases for SH3GLB2 Gene

Aliases for SH3GLB2 Gene

  • SH3 Domain Containing GRB2 Like Endophilin B2 2 3 5
  • SH3 Domain-Containing GRB2-Like Protein B2 3 4
  • SH3-Domain, GRB2-Like, Endophilin B2 2
  • SH3-Domain GRB2-Like Endophilin B2 3
  • Retinoid Receptor-Induced Gene 1 3
  • SH3-Containing Protein SH3GLB2 3
  • Endophilin-B2 3
  • KIAA1848 4
  • PP6569 3
  • PP9455 3
  • RRIG1 3

External Ids for SH3GLB2 Gene

Previous GeneCards Identifiers for SH3GLB2 Gene

  • GC09M122884
  • GC09M123416
  • GC09M125223
  • GC09M127146
  • GC09M128849
  • GC09M130810
  • GC09M131769
  • GC09M101377

Summaries for SH3GLB2 Gene

GeneCards Summary for SH3GLB2 Gene

SH3GLB2 (SH3 Domain Containing GRB2 Like Endophilin B2) is a Protein Coding gene. Among its related pathways are Endocytosis. An important paralog of this gene is SH3GLB1.

Gene Wiki entry for SH3GLB2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3GLB2 Gene

Genomics for SH3GLB2 Gene

Regulatory Elements for SH3GLB2 Gene

Enhancers for SH3GLB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F129025 0.7 FANTOM5 ENCODE 42.7 +1.3 1275 2.5 HDGF SIN3A ZNF48 ZNF2 ZNF121 GLIS2 ELK1 GATA2 ZNF143 KLF7 SH3GLB2 LOC101929314
GH09F129021 0.9 Ensembl ENCODE 40.6 +5.5 5483 3.7 PKNOX1 ATF1 ARNT CREB3L1 SIN3A FEZF1 ZNF2 ZNF121 GLIS2 CBX5 SH3GLB2 URM1 LOC101929314
GH09F128972 1 Ensembl ENCODE 31.4 +55.3 55333 0.7 HDGF MLX ARID4B SIN3A ZNF48 YY1 ZNF143 FOS ZNF263 SP5 SH3GLB2 PHYHD1 KYAT1 LRRC8A LOC100506100 ZDHHC12 PKN3 GC09M128998 DOLK
GH09F128946 0.2 ENCODE 20.2 +80.7 80667 2.2 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 LOC101929314 SH3GLB2 COQ4 SPOUT1 WDR34 USP20 ENSG00000234055 LOC101929270 SPTAN1 NUP188
GH09F128987 1.2 Ensembl ENCODE 12.9 +40.4 40378 1.4 ZNF362 RNF2 JUN ZMYM3 FOSL1 JUND ADNP PRDM10 FOS SH3GLB2 DOLK NUP188 KYAT1 LRRC8A PHYHD1 GC09M128998
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SH3GLB2 on UCSC Golden Path with GeneCards custom track

Promoters for SH3GLB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001315314 253 1001 HDGF ARID4B SIN3A ZNF48 ZNF2 ZNF121 GLIS2 ELK1 ZNF143 ZNF263

Genomic Location for SH3GLB2 Gene

129,007,036 bp from pter
129,028,353 bp from pter
21,318 bases
Minus strand

Genomic View for SH3GLB2 Gene

Genes around SH3GLB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3GLB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3GLB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3GLB2 Gene

Proteins for SH3GLB2 Gene

  • Protein details for SH3GLB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NC47
    • A8MPS4
    • Q8WY61
    • Q96JH9

    Protein attributes for SH3GLB2 Gene

    395 amino acids
    Molecular mass:
    43974 Da
    Quaternary structure:
    • Homodimer, and heterodimer with SH3GLB1.
    • Sequence=AAG23792.1; Type=Frameshift; Positions=122, 128; Evidence={ECO:0000305}; Sequence=BAB47477.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SH3GLB2 Gene


neXtProt entry for SH3GLB2 Gene

Post-translational modifications for SH3GLB2 Gene

  • Ubiquitination at Lys 26 and Lys 276
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SH3GLB2 Gene

Domains & Families for SH3GLB2 Gene

Gene Families for SH3GLB2 Gene

Protein Domains for SH3GLB2 Gene

Suggested Antigen Peptide Sequences for SH3GLB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BAR domain.
  • Belongs to the endophilin family.
  • Contains 1 BAR domain.
  • Contains 1 SH3 domain.
  • Belongs to the endophilin family.
genes like me logo Genes that share domains with SH3GLB2: view

Function for SH3GLB2 Gene

Gene Ontology (GO) - Molecular Function for SH3GLB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11161816
GO:0042802 identical protein binding IPI 20562859
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with SH3GLB2: view
genes like me logo Genes that share phenotypes with SH3GLB2: view

Animal Model Products

miRNA for SH3GLB2 Gene

miRTarBase miRNAs that target SH3GLB2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH3GLB2 Gene

Localization for SH3GLB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH3GLB2 Gene


Subcellular locations from

Jensen Localization Image for SH3GLB2 Gene COMPARTMENTS Subcellular localization image for SH3GLB2 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for SH3GLB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA,IDA 11161816
GO:0005913 cell-cell adherens junction IDA 25468996
genes like me logo Genes that share ontologies with SH3GLB2: view

Pathways & Interactions for SH3GLB2 Gene

SuperPathways for SH3GLB2 Gene

SuperPathway Contained pathways
1 Endocytosis
genes like me logo Genes that share pathways with SH3GLB2: view

Pathways by source for SH3GLB2 Gene

1 KEGG pathway for SH3GLB2 Gene

Gene Ontology (GO) - Biological Process for SH3GLB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with SH3GLB2: view

No data available for SIGNOR curated interactions for SH3GLB2 Gene

Transcripts for SH3GLB2 Gene

Unigene Clusters for SH3GLB2 Gene

SH3-domain GRB2-like endophilin B2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3GLB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12
SP1: - -
SP2: - - - -
SP3: -
SP4: -

Relevant External Links for SH3GLB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH3GLB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SH3GLB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SH3GLB2 Gene

This gene is overexpressed in Frontal cortex (10.6), Peripheral blood mononuclear cells (7.2), and Bone marrow mesenchymal stem cell (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SH3GLB2 Gene

Protein tissue co-expression partners for SH3GLB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SH3GLB2 Gene:


SOURCE GeneReport for Unigene cluster for SH3GLB2 Gene:


mRNA Expression by UniProt/SwissProt for SH3GLB2 Gene:

Tissue specificity: Detected in skeletal muscle, adipocyte, brain, lung, colon and mammary gland.
genes like me logo Genes that share expression patterns with SH3GLB2: view

Primer Products

No data available for mRNA differential expression in normal tissues for SH3GLB2 Gene

Orthologs for SH3GLB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3GLB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SH3GLB2 34 35
  • 99.49 (n)
(Bos Taurus)
Mammalia SH3GLB2 34 35
  • 91.22 (n)
(Canis familiaris)
Mammalia SH3GLB2 34 35
  • 91.18 (n)
(Mus musculus)
Mammalia Sh3glb2 34 16 35
  • 90.38 (n)
(Monodelphis domestica)
Mammalia SH3GLB2 35
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia SH3GLB2 35
  • 76 (a)
(Gallus gallus)
Aves -- 35
  • 79 (a)
SH3GLB2 34 35
  • 77.55 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 25 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3glb2 34
  • 74.87 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12363 34
(Danio rerio)
Actinopterygii sh3glb2b 35
  • 73 (a)
sh3glb2a 34 35
  • 71.87 (n)
zgc55887 34
fruit fly
(Drosophila melanogaster)
Insecta endoB 36 35
  • 38 (a)
(Caenorhabditis elegans)
Secernentea erp-1 34 35
  • 53.54 (n)
F35A5.8b 36
  • 49 (a)
F35A5.8a 36
  • 43 (a)
Species where no ortholog for SH3GLB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3GLB2 Gene

Gene Tree for SH3GLB2 (if available)
Gene Tree for SH3GLB2 (if available)

Paralogs for SH3GLB2 Gene

Paralogs for SH3GLB2 Gene

(1) SIMAP similar genes for SH3GLB2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SH3GLB2: view

Variants for SH3GLB2 Gene

Sequence variations from dbSNP and Humsavar for SH3GLB2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10819457 -- 129,013,762(+) AGCCC(C/T)GAGCA intron-variant
rs10819458 -- 129,016,975(+) TTTGG(G/T)CTCAC intron-variant
rs10988175 -- 129,018,989(+) ATGAA(C/T)TTATA intron-variant
rs10988177 -- 129,024,421(+) CCGGG(C/T)GTGGT intron-variant
rs111332759 -- 129,023,611(+) GAGCA(A/C)GGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH3GLB2 Gene

Variant ID Type Subtype PubMed ID
esv2030052 CNV deletion 18987734
esv2568076 CNV deletion 19546169
esv3621822 CNV loss 21293372
nsv509323 CNV insertion 20534489
nsv818725 CNV gain 17921354
nsv831729 CNV loss 17160897

Variation tolerance for SH3GLB2 Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH3GLB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3GLB2 Gene

Disorders for SH3GLB2 Gene

Relevant External Links for SH3GLB2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SH3GLB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3GLB2 Gene

Publications for SH3GLB2 Gene

  1. SH3GLB, a new endophilin-related protein family featuring an SH3 domain. (PMID: 11161816) Pierrat B. … Heim J. (Genomics 2001) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64

Products for SH3GLB2 Gene

Sources for SH3GLB2 Gene

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