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Aliases for SH3GLB2 Gene

Aliases for SH3GLB2 Gene

  • SH3 Domain Containing GRB2 Like, Endophilin B2 2 3 5
  • SH3 Domain-Containing GRB2-Like Protein B2 3 4
  • SH3-Domain, GRB2-Like, Endophilin B2 2
  • SH3-Domain GRB2-Like Endophilin B2 3
  • Retinoid Receptor-Induced Gene 1 3
  • SH3-Containing Protein SH3GLB2 3
  • Endophilin-B2 3
  • KIAA1848 4
  • PP6569 3
  • PP9455 3
  • RRIG1 3

External Ids for SH3GLB2 Gene

Previous GeneCards Identifiers for SH3GLB2 Gene

  • GC09M122884
  • GC09M123416
  • GC09M125223
  • GC09M127146
  • GC09M128849
  • GC09M130810
  • GC09M131769
  • GC09M101377

Summaries for SH3GLB2 Gene

GeneCards Summary for SH3GLB2 Gene

SH3GLB2 (SH3 Domain Containing GRB2 Like, Endophilin B2) is a Protein Coding gene. Among its related pathways are Endocytosis. An important paralog of this gene is SH3GLB1.

Gene Wiki entry for SH3GLB2 Gene

Additional gene information for SH3GLB2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3GLB2 Gene

Genomics for SH3GLB2 Gene

Regulatory Elements for SH3GLB2 Gene

Enhancers for SH3GLB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H129025 1.6 FANTOM5 ENCODE dbSUPER 42.7 +1.3 1275 2.5 HDGF ATF1 SIN3A ZNF2 ZBTB7B ZNF121 GLIS2 ELK1 GATA2 ZNF143 SH3GLB2 LOC101929314 C9orf50 SPTAN1 ENSG00000272696
GH09H129021 1.6 Ensembl ENCODE dbSUPER 40.6 +5.5 5483 3.7 PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZNF766 CBX5 ZNF143 FOS DEK SH3GLB2 SPOUT1 LOC101929314 ENSG00000272696 ENSG00000272593 SLC25A25-AS1 URM1
GH09H128946 1.1 ENCODE 20.2 +80.7 80667 2.2 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SPOUT1 ENSG00000234055 CIZ1 SH3GLB2 GOLGA2 NUP188 LOC101929314 PRRX2 URM1 COQ4
GH09H128927 1.4 Ensembl ENCODE dbSUPER 11.5 +100.3 100253 0.6 ELF3 ARID4B BRCA1 ZNF2 RAD21 RFX5 ELK1 ZNF143 ZNF207 RCOR1 SH3GLB2 PHYHD1 ENSG00000251184
GH09H128919 1.2 ENCODE dbSUPER 10 +107.0 107044 4.5 ARID4B DMAP1 YY1 SP3 SP5 NFYC NFIL3 MIER3 GLIS1 HNF4A PHYHD1 SH3GLB2 GLE1 ENSG00000251184
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SH3GLB2 on UCSC Golden Path with GeneCards custom track

Promoters for SH3GLB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000241939 353 801 HDGF SIN3A ZNF2 ZBTB7B ZNF121 GLIS2 ELK1 ZNF143 RUNX3 REST

Genomic Locations for SH3GLB2 Gene

Genomic Locations for SH3GLB2 Gene
21,318 bases
Minus strand

Genomic View for SH3GLB2 Gene

Genes around SH3GLB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3GLB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3GLB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3GLB2 Gene

Proteins for SH3GLB2 Gene

  • Protein details for SH3GLB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NC47
    • A8MPS4
    • Q8WY61
    • Q96JH9

    Protein attributes for SH3GLB2 Gene

    395 amino acids
    Molecular mass:
    43974 Da
    Quaternary structure:
    • Homodimer, and heterodimer with SH3GLB1.
    • Sequence=AAG23792.1; Type=Frameshift; Positions=122, 128; Evidence={ECO:0000305}; Sequence=BAB47477.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SH3GLB2 Gene


neXtProt entry for SH3GLB2 Gene

Post-translational modifications for SH3GLB2 Gene

  • Ubiquitination at isoforms=226 and Lys276
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SH3GLB2 Gene

Domains & Families for SH3GLB2 Gene

Gene Families for SH3GLB2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SH3GLB2 Gene

Suggested Antigen Peptide Sequences for SH3GLB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the endophilin family.
  • Belongs to the endophilin family.
genes like me logo Genes that share domains with SH3GLB2: view

Function for SH3GLB2 Gene

Phenotypes From GWAS Catalog for SH3GLB2 Gene

Gene Ontology (GO) - Molecular Function for SH3GLB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11161816
GO:0042802 identical protein binding IPI 20562859
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with SH3GLB2: view
genes like me logo Genes that share phenotypes with SH3GLB2: view

Animal Model Products

miRNA for SH3GLB2 Gene

miRTarBase miRNAs that target SH3GLB2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH3GLB2 Gene

Localization for SH3GLB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH3GLB2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH3GLB2 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SH3GLB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 11161816
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with SH3GLB2: view

Pathways & Interactions for SH3GLB2 Gene

SuperPathways for SH3GLB2 Gene

SuperPathway Contained pathways
1 Endocytosis
genes like me logo Genes that share pathways with SH3GLB2: view

Pathways by source for SH3GLB2 Gene

1 KEGG pathway for SH3GLB2 Gene

Gene Ontology (GO) - Biological Process for SH3GLB2 Gene


No data available for SIGNOR curated interactions for SH3GLB2 Gene

Drugs & Compounds for SH3GLB2 Gene

No Compound Related Data Available

Transcripts for SH3GLB2 Gene

Unigene Clusters for SH3GLB2 Gene

SH3-domain GRB2-like endophilin B2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3GLB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12
SP1: - -
SP2: - - - -
SP3: -
SP4: -

Relevant External Links for SH3GLB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH3GLB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SH3GLB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SH3GLB2 Gene

This gene is overexpressed in Frontal cortex (10.6), Peripheral blood mononuclear cells (7.2), and Bone marrow mesenchymal stem cell (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SH3GLB2 Gene

Protein tissue co-expression partners for SH3GLB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SH3GLB2 Gene:


SOURCE GeneReport for Unigene cluster for SH3GLB2 Gene:


mRNA Expression by UniProt/SwissProt for SH3GLB2 Gene:

Tissue specificity: Detected in skeletal muscle, adipocyte, brain, lung, colon and mammary gland.

Evidence on tissue expression from TISSUES for SH3GLB2 Gene

  • Nervous system(4.8)
  • Muscle(4.3)
  • Lung(2.4)
  • Skin(2)
genes like me logo Genes that share expression patterns with SH3GLB2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SH3GLB2 Gene

Orthologs for SH3GLB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3GLB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SH3GLB2 33 34
  • 99.49 (n)
(Bos Taurus)
Mammalia SH3GLB2 33 34
  • 91.22 (n)
(Canis familiaris)
Mammalia SH3GLB2 33 34
  • 91.18 (n)
(Mus musculus)
Mammalia Sh3glb2 33 16 34
  • 90.38 (n)
(Monodelphis domestica)
Mammalia SH3GLB2 34
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia SH3GLB2 34
  • 76 (a)
(Gallus gallus)
Aves -- 34
  • 79 (a)
SH3GLB2 33 34
  • 77.55 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 25 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3glb2 33
  • 74.87 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12363 33
(Danio rerio)
Actinopterygii sh3glb2b 34
  • 73 (a)
sh3glb2a 33 34
  • 71.87 (n)
zgc55887 33
fruit fly
(Drosophila melanogaster)
Insecta endoB 35 34
  • 38 (a)
(Caenorhabditis elegans)
Secernentea erp-1 33 34
  • 53.54 (n)
F35A5.8b 35
  • 49 (a)
F35A5.8a 35
  • 43 (a)
Species where no ortholog for SH3GLB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3GLB2 Gene

Gene Tree for SH3GLB2 (if available)
Gene Tree for SH3GLB2 (if available)

Paralogs for SH3GLB2 Gene

Paralogs for SH3GLB2 Gene

(1) SIMAP similar genes for SH3GLB2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SH3GLB2: view

Variants for SH3GLB2 Gene

Sequence variations from dbSNP and Humsavar for SH3GLB2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000337231 -- 129,013,580(+) GGCAG(C/T)GCTGG intron-variant
rs1000369878 -- 129,013,743(+) GGCAG(C/G)CTTTA intron-variant
rs1000559114 -- 129,011,454(+) AACGA(C/T)GGCAC intron-variant
rs1000559564 -- 129,007,405(+) TTATA(G/T)CCCCG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1000580362 -- 129,023,377(+) TCTAA(C/G)AGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH3GLB2 Gene

Variant ID Type Subtype PubMed ID
nsv831729 CNV loss 17160897
nsv818725 CNV gain 17921354
nsv509323 CNV insertion 20534489
esv3621822 CNV loss 21293372
esv2568076 CNV deletion 19546169
esv2030052 CNV deletion 18987734

Variation tolerance for SH3GLB2 Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH3GLB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3GLB2 Gene

Disorders for SH3GLB2 Gene

Relevant External Links for SH3GLB2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SH3GLB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3GLB2 Gene

Publications for SH3GLB2 Gene

  1. SH3GLB, a new endophilin-related protein family featuring an SH3 domain. (PMID: 11161816) Pierrat B … Heim J (Genomics 2001) 2 3 4 22 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60

Products for SH3GLB2 Gene

Sources for SH3GLB2 Gene

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