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Aliases for SH3GLB2 Gene

Aliases for SH3GLB2 Gene

  • SH3-Domain GRB2-Like Endophilin B2 2 3
  • SH3 Domain-Containing GRB2-Like Protein B2 3 4
  • SH3-Domain, GRB2-Like, Endophilin B2 2
  • Retinoid Receptor-Induced Gene 1 3
  • SH3-Containing Protein SH3GLB2 3
  • KIAA1848 4
  • PP6569 3
  • PP9455 3
  • RRIG1 3

External Ids for SH3GLB2 Gene

Previous GeneCards Identifiers for SH3GLB2 Gene

  • GC09M122884
  • GC09M123416
  • GC09M125223
  • GC09M127146
  • GC09M128849
  • GC09M130810
  • GC09M131769
  • GC09M101377

Summaries for SH3GLB2 Gene

GeneCards Summary for SH3GLB2 Gene

SH3GLB2 (SH3-Domain GRB2-Like Endophilin B2) is a Protein Coding gene. Among its related pathways are Endocytosis. An important paralog of this gene is SH3GL3.

Gene Wiki entry for SH3GLB2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3GLB2 Gene

Genomics for SH3GLB2 Gene

Regulatory Elements for SH3GLB2 Gene

Genomic Location for SH3GLB2 Gene

129,007,036 bp from pter
129,028,353 bp from pter
21,318 bases
Minus strand

Genomic View for SH3GLB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SH3GLB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3GLB2 Gene

Proteins for SH3GLB2 Gene

  • Protein details for SH3GLB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NC47
    • A8MPS4
    • Q8WY61
    • Q96JH9

    Protein attributes for SH3GLB2 Gene

    395 amino acids
    Molecular mass:
    43974 Da
    Quaternary structure:
    • Homodimer, and heterodimer with SH3GLB1
    • Sequence=AAG23792.1; Type=Frameshift; Positions=122, 128; Evidence={ECO:0000305}; Sequence=BAB47477.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SH3GLB2 Gene


neXtProt entry for SH3GLB2 Gene

Proteomics data for SH3GLB2 Gene at MOPED

Post-translational modifications for SH3GLB2 Gene

  • Ubiquitination at Lys 26 and Lys 276
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SH3GLB2 Gene

Domains & Families for SH3GLB2 Gene

Protein Domains for SH3GLB2 Gene

Suggested Antigen Peptide Sequences for SH3GLB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BAR domain.
  • Belongs to the endophilin family.
  • Contains 1 BAR domain.
  • Contains 1 SH3 domain.
  • Belongs to the endophilin family.
genes like me logo Genes that share domains with SH3GLB2: view

No data available for Gene Families for SH3GLB2 Gene

Function for SH3GLB2 Gene

Gene Ontology (GO) - Molecular Function for SH3GLB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11161816
genes like me logo Genes that share ontologies with SH3GLB2: view
genes like me logo Genes that share phenotypes with SH3GLB2: view

miRNA for SH3GLB2 Gene

miRTarBase miRNAs that target SH3GLB2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SH3GLB2 Gene

Localization for SH3GLB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH3GLB2 Gene


Subcellular locations from

Jensen Localization Image for SH3GLB2 Gene COMPARTMENTS Subcellular localization image for SH3GLB2 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for SH3GLB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 11161816
genes like me logo Genes that share ontologies with SH3GLB2: view

Pathways & Interactions for SH3GLB2 Gene

SuperPathways for SH3GLB2 Gene

Superpath Contained pathways
1 Endocytosis
genes like me logo Genes that share pathways with SH3GLB2: view

Pathways by source for SH3GLB2 Gene

1 KEGG pathway for SH3GLB2 Gene

Gene Ontology (GO) - Biological Process for SH3GLB2 Gene


No data available for SIGNOR curated interactions for SH3GLB2 Gene

Drugs & Compounds for SH3GLB2 Gene

No Compound Related Data Available

Transcripts for SH3GLB2 Gene

Unigene Clusters for SH3GLB2 Gene

SH3-domain GRB2-like endophilin B2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SH3GLB2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3GLB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12
SP1: - -
SP2: - - - -
SP3: -
SP4: -

Relevant External Links for SH3GLB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH3GLB2 Gene

mRNA expression in normal human tissues for SH3GLB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SH3GLB2 Gene

This gene is overexpressed in Frontal cortex (10.6), Peripheral blood mononuclear cells (7.2), and Bone marrow mesenchymal stem cell (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SH3GLB2 Gene

SOURCE GeneReport for Unigene cluster for SH3GLB2 Gene Hs.460238

mRNA Expression by UniProt/SwissProt for SH3GLB2 Gene

Tissue specificity: Detected in skeletal muscle, adipocyte, brain, lung, colon and mammary gland.
genes like me logo Genes that share expression patterns with SH3GLB2: view

Protein tissue co-expression partners for SH3GLB2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SH3GLB2 Gene

Orthologs for SH3GLB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3GLB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SH3GLB2 35
  • 91.22 (n)
  • 96.2 (a)
SH3GLB2 36
  • 96 (a)
(Canis familiaris)
Mammalia SH3GLB2 35
  • 91.18 (n)
  • 97.09 (a)
SH3GLB2 36
  • 97 (a)
(Mus musculus)
Mammalia Sh3glb2 35
  • 90.38 (n)
  • 96.71 (a)
Sh3glb2 16
Sh3glb2 36
  • 97 (a)
(Pan troglodytes)
Mammalia SH3GLB2 35
  • 99.49 (n)
  • 99.75 (a)
SH3GLB2 36
  • 99 (a)
(Monodelphis domestica)
Mammalia SH3GLB2 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia SH3GLB2 36
  • 76 (a)
(Gallus gallus)
Aves SH3GLB2 35
  • 77.55 (n)
  • 83.04 (a)
-- 36
  • 79 (a)
SH3GLB2 36
  • 82 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 25 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3glb2 35
  • 74.87 (n)
  • 81.28 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12363 35
(Danio rerio)
Actinopterygii sh3glb2a 35
  • 71.87 (n)
  • 76.46 (a)
zgc55887 35
sh3glb2a 36
  • 76 (a)
sh3glb2b 36
  • 73 (a)
fruit fly
(Drosophila melanogaster)
Insecta endoB 37
  • 38 (a)
endoB 36
  • 42 (a)
(Caenorhabditis elegans)
Secernentea F35A5.8a 37
  • 43 (a)
F35A5.8b 37
  • 49 (a)
erp-1 35
  • 53.54 (n)
  • 49.04 (a)
erp-1 36
  • 47 (a)
Species with no ortholog for SH3GLB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3GLB2 Gene

Gene Tree for SH3GLB2 (if available)
Gene Tree for SH3GLB2 (if available)

Paralogs for SH3GLB2 Gene

Paralogs for SH3GLB2 Gene

(1) SIMAP similar genes for SH3GLB2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SH3GLB2: view

Variants for SH3GLB2 Gene

Sequence variations from dbSNP and Humsavar for SH3GLB2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1129098 -- 129,009,226(-) CCTCC(A/G)GGGGA synonymous-codon, reference
rs1140159 -- 129,009,262(-) ACTAT(A/G)CCTGT missense, reference
rs1574303 -- 129,029,543(+) GTCAC(A/G)GGAAG upstream-variant-2KB
rs3210583 -- 129,008,733(+) GAGAG(A/G)CAACA missense, reference
rs3210584 -- 129,008,731(-) GAGGC(A/G)ACAAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SH3GLB2 Gene

Variant ID Type Subtype PubMed ID
nsv893902 CNV Gain 21882294
dgv8297n71 CNV Loss 21882294
nsv831729 CNV Loss 17160897
nsv509323 CNV Insertion 20534489
esv2568076 CNV Deletion 19546169
esv2030052 CNV Deletion 18987734
nsv818725 CNV Gain 17921354

Variation tolerance for SH3GLB2 Gene

Residual Variation Intolerance Score: 45.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH3GLB2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3GLB2 Gene

Disorders for SH3GLB2 Gene

Relevant External Links for SH3GLB2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SH3GLB2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3GLB2 Gene

Publications for SH3GLB2 Gene

  1. SH3GLB, a new endophilin-related protein family featuring an SH3 domain. (PMID: 11161816) Pierrat B. … Heim J. (Genomics 2001) 2 23 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  3. A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome. (PMID: 23414517) Blandin G. … Richard I. (Skelet Muscle 2013) 67
  4. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 67
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 67

Products for SH3GLB2 Gene

Sources for SH3GLB2 Gene

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