Aliases for SH3GLB1 Gene
External Ids for SH3GLB1 Gene
This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
GeneCards Summary for SH3GLB1 Gene
SH3GLB1 (SH3-Domain GRB2-Like Endophilin B1) is a Protein Coding gene. Among its related pathways are Endocytosis and Delta508-CFTR traffic / ER-to-Golgi in CF. GO annotations related to this gene include protein homodimerization activity and fatty acid binding. An important paralog of this gene is SH3GLB2.
UniProtKB/Swiss-Prot for SH3GLB1 Gene
May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion.