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SH3GL3 Gene

protein-coding   GIFtS: 58
GCID: GC15P084115

SH3-Domain GRB2-Like 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
SH3-Domain GRB2-Like 31 2     EEN-2B-L32
CNSA32 3     HsT193712
EEN-B22 3     SH3P132
SH3D2C2 3     endophilin-32
SH3 Domain Protein 2C2 3     endophilin-A32
SH3 Domain-Containing GRB2-Like Protein 32 3     Endophilin-33

External Ids:    HGNC: 108321   Entrez Gene: 64572   Ensembl: ENSG000001406007   OMIM: 6033625   UniProtKB: Q999633   
ORGUL members:         

Export aliases for SH3GL3 gene to outside databases

Previous GC identifers: GC15P080042 GC15P077149 GC15P081694 GC15P081836 GC15P081907 GC15P060379


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SH3GL3 Gene:
SH3GL3 (SH3-domain GRB2-like 3) is a protein-coding gene. Diseases associated with SH3GL3 include oral cavity cancer, and cblc. GO annotations related to this gene include lipid binding and identical protein binding. An important paralog of this gene is SH3GL1.

UniProtKB/Swiss-Prot: SH3G3_HUMAN, Q99963
Function: Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity)

Gene Wiki entry for SH3GL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SH3GL3 gene promoter:
         AhR   Sox5   AML1a   YY1   Arnt   AREB6   Nkx6-1   Ik-2   HOXA5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSH3GL3 promoter sequence
   Search Chromatin IP Primers for SH3GL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SH3GL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24   Ensembl cytogenetic band:  15q25.2   HGNC cytogenetic band: 15q24

SH3GL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SH3GL3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P084115:  view genomic region     (about GC identifiers)

Start:
84,115,980 bp from pter      End:
84,287,495 bp from pter
Size:
171,516 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SH3G3_HUMAN, Q99963 (See protein sequence)
Recommended Name: Endophilin-A3  
Size: 347 amino acids; 39285 Da
Subunit: Interacts with ARC (By similarity). Interacts with DNM1, SGIP1 and SYNJ1. Interacts with the huntingtin
exon 1 protein (HDEX1P) containing a glutamine repeat in the pathological range and promotes formation of
insoluble polyglutamine-containing aggregates in vivo. Interacts with DYDC1. Interacts with FASLG. Interacts with
ATX2. Interacts with BIN2
2 PDB 3D structures from and Proteopedia for SH3GL3:
2EW3 (3D)        2Z0V (3D)    
Secondary accessions: O43553 O43554
Alternative splicing: 4 isoforms:  Q99963-1   Q99963-2   Q99963-3   Q99963-4   

Explore the universe of human proteins at neXtProt for SH3GL3: NX_Q99963

Explore proteomics data for SH3GL3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SH3GL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003018.3  
    ENSEMBL proteins: 
     ENSP00000391372   ENSP00000456249   ENSP00000320092   ENSP00000439239   ENSP00000397871  

    SH3GL3 Human Recombinant Protein Products:

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    SH3GL3 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR027267 AH/BAR-dom
     IPR028508 Endophilin-A3
     IPR001452 SH3_domain
     IPR004148 BAR_dom

    Graphical View of Domain Structure for InterPro Entry Q99963

    ProtoNet protein and cluster: Q99963

    1 Blocks protein domain: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: SH3G3_HUMAN, Q99963
    Domain: An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of
    the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes (By similarity)
    Similarity: Belongs to the endophilin family
    Similarity: Contains 1 BAR domain
    Similarity: Contains 1 SH3 domain


    SH3GL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SH3G3_HUMAN, Q99963
    Function: Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity)

         Genatlas biochemistry entry for SH3GL3:
    Src-homology 3 domain GRB2-like gene 3,expressed in brain and testis

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15383276
    GO:0008289lipid binding IEA--
    GO:0042802identical protein binding IPI16115810
         
    SH3GL3 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sh3gl3):
     behavior/neurological  growth/size/body  mortality/aging  nervous system  no phenotypic analysis 
     normal  respiratory system 

    SH3GL3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sh3gl3tm1.2Itl for SH3GL3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SH3GL3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SH3GL3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SH3GL3

    miRNA
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    miRTarBase miRNAs that target SH3GL3:
    hsa-mir-196a-5p (MIRT048236)

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3GL3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SH3G3_HUMAN, Q99963: Cytoplasm (By similarity). Early endosome membrane; Peripheral membrane protein (By
    similarity). Note=Associated with postsynaptic endosomes in hippocampal neurons. Associated with presynaptic
    endosomes in olfactory neurons (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytosol3
    nucleus2
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0031901early endosome membrane IEA--

    SH3GL3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SH3GL3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Endocytosis
    Endocytosis
    2EGFR1 Signaling Pathway
    EGFR1 Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SH3GL3
        EGFR1 Signaling Pathway


    1 Kegg Pathway  (Kegg details for SH3GL3):
        Endocytosis


    SH3GL3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SH3GL3
    Interactions:

        GeneGlobe Interaction Network for SH3GL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SH3GL3 (Q999631, 2, 3 ENSP000003913724) via UniProtKB, MINT, STRING, and/or I2D (see all 91)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HTTP428581, 2, 3, ENSP000003471844EBI-473910,EBI-466029 MINT-7101514 MINT-7101421 MINT-3978011 MINT-7101561 MINT-3978450 MINT-7101535 MINT-7101548 MINT-3978571 I2D: score=5 STRING: ENSP00000347184
    ATXN2Q997001, 2, 3, ENSP000003668434EBI-473910,EBI-697691 MINT-7310089 MINT-2863161 MINT-2863142 MINT-7310056 MINT-7310016 MINT-7310071 I2D: score=3 STRING: ENSP00000366843
    SH3GL1Q999611, 2, 3, ENSP000002698864EBI-473910,EBI-697911 MINT-8270363 I2D: score=5 STRING: ENSP00000269886
    SH3KBP1Q96B972, 3, ENSP000003809214MINT-15312 MINT-15311 MINT-15313 MINT-8270671 I2D: score=4 STRING: ENSP00000380921
    SNX24Q9Y3432, 3, ENSP000002613694MINT-65814 I2D: score=4 STRING: ENSP00000261369
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0007165signal transduction TAS9169142
    GO:0007417central nervous system development TAS9169142

    SH3GL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SH3GL3 (SH3G3)

    1 Novoseek inferred chemical compound relationship for SH3GL3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamine 44 2 14715959 (1), 9809064 (1)



    SH3GL3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SH3GL3 gene: 
    NM_003027.3  

    Unigene Cluster for SH3GL3:

    SH3-domain GRB2-like 3
    Hs.270055  [show with all ESTs]
    Unigene Representative Sequence: NM_003027
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000492099(uc010bms.2) ENST00000427482(uc010uot.1 uc002bjw.3 uc002bjx.3)
    ENST00000563901 ENST00000324537(uc002bju.3) ENST00000564054 ENST00000467735
    ENST00000535412(uc002bjv.3) ENST00000434347
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SH3GL3
      QuantiFast Probe-based Assays in human, mouse, rat SH3GL3

    Additional mRNA sequence: 

    AF036269.1 AK307442.1 AK309086.1 AL109775.1 BC035598.1 NR_026799.1 X99664.1 

    8 DOTS entries:

    DT.91742599  DT.455415  DT.95375812  DT.100749469  DT.431276  DT.121066402  DT.75176880  DT.100749468 

    Selected AceView cDNA sequences (see all 52):

    BC035598 AF036271 AI217188 NM_003027 BP367004 BX108620 BI544603 T05714 
    BI668418 BI597342 CF455689 AA400405 AF036270 BC042864 AA432226 F12421 
    AI336437 BI547720 BI545363 AV724917 BI599045 AI207911 X99664 AL109775 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SH3GL3    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                                        -                                         -               
    SP2:                          -     -     -                 -                                                         
    SP3:                          -     -     -                 -                                         -               
    SP4:                          -     -     -                 -     -                                   -               
    SP5:                          -     -     -                                                                           


    ECgene alternative splicing isoforms for SH3GL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SH3GL3 expression in normal human tissues (normalized intensities)      SH3GL3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTTGGGG
    SH3GL3 Expression
    About this image


    SH3GL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Thalamus
     
     Testis (Reproductive System)
             Testis Interstitium
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Peripheral Nervous System (Nervous System)
             Pro-myelinating Schwann Cells Peripheral Nerve Domain
     
     Liver (Hepatobiliary System)
             Mesothelial Cells Hepatic Mesenchyme
    SH3GL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SH3GL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.270055

    UniProtKB/Swiss-Prot: SH3G3_HUMAN, Q99963
    Tissue specificity: Brain and testis

        Custom PCR Arrays for SH3GL3
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3GL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SH3GL3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sh3gl31 , 5 SH3-domain GRB2-like 31, 5 87.19(n)1
    86.71(a)1
      7 (47.15 cM)5
    204081  NM_017400.61  NP_059096.31 
     821738405 
    chicken
    (Gallus gallus)
    Aves SH3GL31 SH3-domain GRB2-like 3 78.67(n)
    83.86(a)
      395201  NM_204528.1  NP_989859.1 
    lizard
    (Anolis carolinensis)
    Reptilia SH3GL36
    SH3-domain GRB2-like 3
    64(a)
    1 ↔ 1
    GL344365.1(447-6133)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sh3gl31 SH3-domain GRB2-like 3 74.18(n)
    78.9(a)
      100492562  XM_002940099.2  XP_002940145.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sh3gl3a1 SH3-domain GRB2-like 3a 71.95(n)
    78.39(a)
      571626  NM_001081691.2  NP_001075160.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta endoA1 , 3 synaptic vesicle endocytosis
    lysophosphatidic more3
    endophilin A1
    49(a)3
    56.98(n)1
    55.23(a)1
      91D43
    422651  NM_001275788.11  NP_001262717.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T04D1.33
    unc-571
    unc-571 50(a)3
    54.52(n)1
    51.02(a)1
      I(4675134-4676809)3
    1720781  NM_001047215.31  NP_001040680.11 


    ENSEMBL Gene Tree for SH3GL3 (if available)
    TreeFam Gene Tree for SH3GL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SH3GL3 gene
    SH3GL12  SH3GLB12  SH3GL22  SH3GLB22  
    3 SIMAP similar genes for SH3GL3 using alignment to 3 protein entries:     SH3G3_HUMAN (see all proteins):
    SH3GL1    SH3GL2    DKFZp686B23205

    SH3GL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SH3GL3 (see all 3010)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58141511,2
    C--63848402(+) AATCT-/AAAAAAAA 2 -- int10--------
    rs1411645701,2
    --84114207(+) GTAGCA/GATGAT 2 -- us2k10--------
    rs1923046761,2
    --84114267(+) AATAAA/GTCTAT 2 -- us2k10--------
    rs727583911,2
    C,F--84114419(+) AGAAAC/TTTGAA 2 -- us2k12Minor allele frequency- T:0.11WA NA 238
    rs1849992241,2
    --84114428(+) AATGTA/GCTAAC 2 -- us2k10--------
    rs1871154771,2
    --84114429(+) ATGTAC/GTAACG 2 -- us2k10--------
    rs1922357291,2
    --84114455(+) CCAATA/TAACTG 2 -- us2k10--------
    rs1844342341,2
    --84114503(+) AGAGCC/TGGATT 2 -- us2k10--------
    rs1116937961,2
    F--84114669(+) GCCTGC/TGGTGA 2 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs20551441,2
    C,A,H--84114698(-) ACAGTC/TCAAAT 2 -- us2k117Minor allele frequency- T:0.00NS EA NA WA CSA 792

    HapMap Linkage Disequilibrium report for SH3GL3 (84115980 - 84287495 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SH3GL3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749962CNV Deletion23290073
    esv3630CNV Deletion18987735
    esv2662956CNV Deletion23128226
    esv2749961CNV Deletion23290073
    esv5633CNV Loss19470904
    nsv1642CNV Loss18451855
    nsv457216CNV Loss19166990
    nsv833072CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SH3GL3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603362    OMIM disorders: --

    12 diseases for SH3GL3:    About MalaCards
    oral cavity cancer    cblc    huntington's disease    cerebellar ataxia
    wiskott-aldrich syndrome    gout    ataxia    colorectal cancer
    hepatitis    leukemia    neuronitis    malaria


    SH3GL3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SH3GL3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    huntington disease 65.7 1 9878254 (1)

    Genetic Association Database (GAD): SH3GL3
    Human Genome Epidemiology (HuGE) Navigator: SH3GL3 (2 documents)

    Export disorders for SH3GL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SH3GL3 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with SH3GL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel SH3-containing human gene family preferentially expressed in the central nervous system. (PubMed id 9169142)1, 2, 3 Giachino C....Migone N. (Genomics 1997)
    2. SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates. (PubMed id 9809064)1, 2, 9 Sittler A.... Wanker E.E. (Mol. Cell 1998)
    3. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
    4. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M.... Janssen O. (BMC Immunol. 2009)
    5. Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. (PubMed id 19266077)1, 4 Sovio U....Jarvelin M.R. (PLoS Genet. 2009)
    6. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    7. Identification of ten loci associated with height highlights new biological pathways in human growth. (PubMed id 18391950)1, 4 Lettre G.... Hirschhorn J.N. (Nat. Genet. 2008)
    8. Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking. (PubMed id 18602463)1, 2 Nonis D....Auburger G. (Cell. Signal. 2008)
    9. Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance. (PubMed id 15919751)1, 2 Trevaskis J.... Collier G.R. (Endocrinology 2005)
    10. The SH3 domains of endophilin and amphiphysin bind to the proline- rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity. (PubMed id 10542231)1, 2 Cestra G.... Cesareni G. (J. Biol. Chem. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6457 HGNC: 10832 AceView: SH3GL3 Ensembl:ENSG00000140600 euGenes: HUgn6457
    ECgene: SH3GL3 Kegg: 6457 H-InvDB: SH3GL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SH3GL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SH3GL3 gene:
    Search GeneIP for patents involving SH3GL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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