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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SH3GL3 Gene

protein-coding   GIFtS: 59
GCID: GC15P084115

SH3-Domain GRB2-Like 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
SH3-Domain GRB2-Like 31 2     EEN-2B-L32
CNSA32 3     HsT193712
EEN-B22 3     SH3P132
SH3D2C2 3     endophilin-32
SH3 Domain Protein 2C2 3     endophilin-A32
SH3 Domain-Containing GRB2-Like Protein 32 3     Endophilin-33

External Ids:    HGNC: 108321   Entrez Gene: 64572   Ensembl: ENSG000001406007   OMIM: 6033625   UniProtKB: Q999633   
ORGUL members:         
NONCODE14:n407336      

Export aliases for SH3GL3 gene to outside databases

Previous GC identifers: GC15P080042 GC15P077149 GC15P081694 GC15P081836 GC15P081907 GC15P060379


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SH3GL3 Gene: 
SH3GL3 (SH3-domain GRB2-like 3) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with SH3GL3 include oral cavity cancer, and huntington's disease. GO annotations related to this gene include lipid binding and identical protein binding. An important paralog of this gene is SH3GL1.

UniProtKB/Swiss-Prot: SH3G3_HUMAN, Q99963
Function: Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity)

Gene Wiki entry for SH3GL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_077661.3  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SH3GL3 gene promoter:
         AhR   Sox5   AML1a   YY1   Arnt   AREB6   Nkx6-1   Ik-2   HOXA5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSH3GL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SH3GL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH3GL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24   Ensembl cytogenetic band:  15q25.2   HGNC cytogenetic band: 15q24

SH3GL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SH3GL3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P084115:  view genomic region     (about GC identifiers)

Start:
84,115,980 bp from pter      End:
84,287,495 bp from pter
Size:
171,516 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SH3G3_HUMAN, Q99963 (See protein sequence)
Recommended Name: Endophilin-A3  
Size: 347 amino acids; 39285 Da
Subunit: Interacts with ARC (By similarity). Interacts with DNM1, SGIP1 and SYNJ1. Interacts with the huntingtin
exon 1 protein (HDEX1P) containing a glutamine repeat in the pathological range and promotes formation of
insoluble polyglutamine-containing aggregates in vivo. Interacts with DYDC1. Interacts with FASLG. Interacts with
ATX2. Interacts with BIN2
Subcellular location: Cytoplasm (By similarity). Early endosome membrane; Peripheral membrane protein (By
similarity). Note=Associated with postsynaptic endosomes in hippocampal neurons. Associated with presynaptic
endosomes in olfactory neurons (By similarity)
2 PDB 3D structures from and Proteopedia for SH3GL3:
2EW3 (3D)        2Z0V (3D)    
Secondary accessions: O43553 O43554
Alternative splicing: 4 isoforms:  Q99963-1   Q99963-2   Q99963-3   Q99963-4   

Explore the universe of human proteins at neXtProt for SH3GL3: NX_Q99963

Explore proteomics data for SH3GL3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99963

  • SH3GL3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SH3GL3 Protein Expression
    REFSEQ proteins: NP_003018.3  
    ENSEMBL proteins: 
     ENSP00000391372   ENSP00000456249   ENSP00000320092   ENSP00000439239   ENSP00000397871  

    Human Recombinant Protein Products for SH3GL3: 
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    Novus Biologicals SH3GL3 Protein
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SH3GL3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0031901early endosome membrane IEA--

    SH3GL3 for ontologies           About GeneDecksing



    SH3GL3 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR027267 AH/BAR-dom
     IPR001452 SH3_domain
     IPR004148 BAR_dom

    Graphical View of Domain Structure for InterPro Entry Q99963

    ProtoNet protein and cluster: Q99963

    1 Blocks protein domain: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: SH3G3_HUMAN, Q99963
    Domain: An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of
    the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes (By similarity)
    Similarity: Belongs to the endophilin family
    Similarity: Contains 1 BAR domain
    Similarity: Contains 1 SH3 domain


    SH3GL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SH3G3_HUMAN, Q99963
    Function: Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity)

         Genatlas biochemistry entry for SH3GL3:
    Src-homology 3 domain GRB2-like gene 3,expressed in brain and testis

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15383276
    GO:0008289lipid binding IEA--
    GO:0042802identical protein binding IPI16115810
         
    SH3GL3 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sh3gl3):
     behavior/neurological  growth/size  mortality/aging  nervous system  no phenotypic analysis 
     normal  respiratory system 

    SH3GL3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sh3gl3tm1.2Itl for SH3GL3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SH3GL3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SH3GL3

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    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3GL3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SH3GL3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Endocytosis
    Endocytosis
    2EGFR1 Signaling Pathway
    EGFR1 Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SH3GL3
        EGFR1 Signaling Pathway


    1         Kegg Pathway  (Kegg details for SH3GL3):
        Endocytosis


    SH3GL3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SH3GL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/90 Interacting proteins for SH3GL3 (Q999631, 2, 3 ENSP000003913724) via UniProtKB, MINT, STRING, and/or I2D (see all 90)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HTTP428581, 2, 3, ENSP000003471844EBI-473910,EBI-466029 MINT-7101514 MINT-7101421 MINT-3978011 MINT-7101561 MINT-3978450 MINT-7101535 MINT-7101548 MINT-3978571 I2D: score=5 STRING: ENSP00000347184
    ATXN2Q997001, 2, 3, ENSP000003668434EBI-473910,EBI-697691 MINT-7310089 MINT-2863161 MINT-2863142 MINT-7310056 MINT-7310016 MINT-7310071 I2D: score=3 STRING: ENSP00000366843
    SH3GL1Q999611, 2, 3, ENSP000002698864EBI-473910,EBI-697911 MINT-8270363 I2D: score=5 STRING: ENSP00000269886
    SH3KBP1Q96B972, 3, ENSP000003809214MINT-15312 MINT-15311 MINT-15313 MINT-8270671 I2D: score=4 STRING: ENSP00000380921
    SNX24Q9Y3432, 3, ENSP000002613694MINT-65814 I2D: score=4 STRING: ENSP00000261369
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0007165signal transduction TAS9169142
    GO:0007417central nervous system development TAS9169142

    SH3GL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SH3GL3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SH3GL3 (SH3G3)

    1 Novoseek inferred chemical compound relationship for SH3GL3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamine 44 2 14715959 (1), 9809064 (1)

    Search CenterWatch for drugs/clinical trials and news about SH3GL3 / SH3G3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SH3GL3 gene: 
    NM_003027.3  

    Unigene Clusters for SH3GL3:

    SH3-domain GRB2-like 3
    Hs.270055  [show with all ESTs], Hs.666365
    Unigene Representative Sequences: NM_003027, AF036272
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000492099(uc010bms.2) ENST00000427482(uc010uot.1 uc002bjw.3 uc002bjx.3)
    ENST00000563901 ENST00000324537(uc002bju.3) ENST00000564054 ENST00000467735
    ENST00000535412(uc002bjv.3) ENST00000434347
    miRNA
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    Additional mRNA sequence: AF036272.1 

    8 DOTS entries:

    DT.91742599  DT.455415  DT.95375812  DT.100749469  DT.431276  DT.100749468  DT.121066402  DT.75176880 

    24/52 AceView cDNA sequences (see all 52):

    BC035598 NM_003027 AI217188 BP367004 BX108620 AF036271 AA432226 AL109775 
    BI597342 X99664 AI336437 T05714 BI599045 BI544603 BI545363 AI333036 
    F12421 BC042864 BI668418 F10038 AI207911 BI547720 AV724917 AF036270 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SH3GL3    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                                        -                                         -               
    SP2:                          -     -     -                 -                                                         
    SP3:                          -     -     -                 -                                         -               
    SP4:                          -     -     -                 -     -                                   -               
    SP5:                          -     -     -                                                                           


    ECgene alternative splicing isoforms for SH3GL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SH3GL3 expression in normal human tissues (normalized intensities)      SH3GL3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTTGGGG
    SH3GL3 Expression
    About this image


    SH3GL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Thalamus
     
     Testis (Reproductive System)
             Testis Interstitium
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Peripheral Nervous System (Nervous System)
             Pro-myelinating Schwann Cells Peripheral Nerve Domain
     
     Inner Cell Mass (Early Embryonic Tissues)
             ESI-053   

    See SH3GL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SH3GL3

    SOURCE GeneReport for Unigene clusters: Hs.270055 Hs.666365

    UniProtKB/Swiss-Prot: SH3G3_HUMAN, Q99963
    Tissue specificity: Brain and testis

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3GL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SH3GL3 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sh3gl31 , 5 SH3-domain GRB2-like 31, 5 87.19(n)1
    86.71(a)1
      7 (47.15 cM)5
    204081  NM_017400.51  NP_059096.31 
     821738405 
    chicken
    (Gallus gallus)
    Aves SH3GL31 SH3-domain GRB2-like 3 78.67(n)
    83.86(a)
      395201  NM_204528.1  NP_989859.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    SH3GL36
    Uncharacterized protein
    82(a)
    65(a)
    possible ortholog
    1 ↔ 1
    AAWZ02039932(604-807)
    GL344365.1(447-6133)
    zebrafish
    (Danio rerio)
    Actinopterygii sh3gl3a1 SH3-domain GRB2-like 3a 71.95(n)
    78.39(a)
      571626  NM_001081691.2  NP_001075160.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta endoA1 , 3 synaptic vesicle endocytosis
    lysophosphatidic more3
    endophilin A1
    49(a)3
    56.98(n)1
    55.23(a)1
      91D43
    422651  NM_138767.21  NP_620122.21 
    worm
    (Caenorhabditis elegans)
    Secernentea T04D1.33   -- 50(a)   I(4675134-4676809)   --


    ENSEMBL Gene Tree for SH3GL3 (if available)
    TreeFam Gene Tree for SH3GL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SH3GL3 gene
    SH3GL12  SH3GLB12  SH3GL22  SH3GLB22  
    3 SIMAP similar genes for SH3GL3 using alignment to 3 protein entries:     SH3G3_HUMAN (see all proteins):
    SH3GL1    SH3GL2    DKFZp686B23205

    SH3GL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3010 SNPs in SH3GL3 are shown (see all 3010)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58141511,2
    C--63848402(+) AATCT-/AAAAAAAA 2 -- int10--------
    rs1411645701,2
    --84114207(+) GTAGCA/GATGAT 2 -- us2k10--------
    rs1923046761,2
    --84114267(+) AATAAA/GTCTAT 2 -- us2k10--------
    rs727583911,2
    C,F--84114419(+) AGAAAC/TTTGAA 2 -- us2k12Minor allele frequency- T:0.11WA NA 238
    rs1849992241,2
    --84114428(+) AATGTA/GCTAAC 2 -- us2k10--------
    rs1871154771,2
    --84114429(+) ATGTAC/GTAACG 2 -- us2k10--------
    rs1922357291,2
    --84114455(+) CCAATA/TAACTG 2 -- us2k10--------
    rs1844342341,2
    --84114503(+) AGAGCC/TGGATT 2 -- us2k10--------
    rs1116937961,2
    F--84114669(+) GCCTGC/TGGTGA 2 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs20551441,2
    C,A,H--84114698(-) ACAGTC/TCAAAT 2 -- us2k117Minor allele frequency- T:0.00NS EA NA WA CSA 792

    HapMap Linkage Disequilibrium report for SH3GL3 (84115980 - 84287495 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SH3GL3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2749962CNV Deletion23290073
    esv3630CNV Deletion18987735
    esv2662956CNV Deletion23128226
    esv2749961CNV Deletion23290073
    esv5633CNV Loss19470904
    nsv1642CNV Loss18451855
    nsv457216CNV Loss19166990
    nsv833072CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603362    OMIM disorders: --

    10 diseases for SH3GL3:    About MalaCards
    oral cavity cancer    huntington's disease    cblc    cerebellar ataxia
    wiskott-aldrich syndrome    gout    ataxia    colorectal cancer
    leukemia    neuronitis


    SH3GL3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SH3GL3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    huntington disease 65.7 1 9878254 (1)

    Genetic Association Database (GAD): SH3GL3
    Human Genome Epidemiology (HuGE) Navigator: SH3GL3 (2 documents)

    Export disorders for SH3GL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SH3GL3 gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with SH3GL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel SH3-containing human gene family preferentially expressed in the central nervous system. (PubMed id 9169142)1, 2, 3 Giachino C....Migone N. (1997)
    2. SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates. (PubMed id 9809064)1, 2, 9 Sittler A.... Wanker E.E. (1998)
    3. The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (2010)
    4. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M....Janssen O. (2009)
    5. Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. (PubMed id 19266077)1, 4 Sovio U....Jarvelin M.R. (2009)
    6. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (2008)
    7. Identification of ten loci associated with height highlights new biological pathways in human growth. (PubMed id 18391950)1, 4 Lettre G....Hirschhorn J.N. (2008)
    8. Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking. (PubMed id 18602463)1, 2 Nonis D....Auburger G. (2008)
    9. Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance. (PubMed id 15919751)1, 2 Trevaskis J.... Collier G.R. (2005)
    10. The SH3 domains of endophilin and amphiphysin bind to the proline- rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity. (PubMed id 10542231)1, 2 Cestra G.... Cesareni G. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6457 HGNC: 10832 AceView: SH3GL3 Ensembl:ENSG00000140600 euGenes: HUgn6457
    ECgene: SH3GL3 Kegg: 6457 H-InvDB: SH3GL3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SH3GL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SH3GL3 gene:
    Search GeneIP for patents involving SH3GL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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