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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SH3GL3 Gene

protein-coding   GIFtS: 59
GCID: GC15P084115

SH3-domain GRB2-like 3
 Explore 9 diseases affiliated with
SH3GL3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SH3GL3    

Aliases
for SH3GL3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
SH3-Domain GRB2-Like 31 2     SH3 Domain Protein 2C2 3
CNSA31 2 3     SH3 Domain-Containing GRB2-Like Protein 32 3
EEN-B21 2 3     EEN-2B-L32
SH3D2C1 2 3     Endophilin-33
HsT193711 2     Endophilin-A31
SH3P131 2     Endophilin-33

External Ids:    HGNC: 108321   Entrez Gene: 64572   Ensembl: ENSG000001406007   OMIM: 6033625   UniProtKB: Q999633   
ORGUL members:         
NONCODE:n407336    

Export aliases for SH3GL3 gene to outside databases

Previous GC identifers: GC15P080042 GC15P077149 GC15P081694 GC15P081836 GC15P081907 GC15P060379


Summaries
for SH3GL3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SH3G3_HUMAN, Q99963
Function: Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity)

Gene Wiki entry for SH3GL3


Genomic Views
for SH3GL3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_077661.3  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SH3GL3 gene promoter:
         AhR   Sox5   AML1a   YY1   Arnt   AREB6   Nkx6-1   Ik-2   HOXA5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SH3GL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SH3GL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH3GL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24   Ensembl cytogenetic band:  15q25.2   HGNC cytogenetic band: 15q24

SH3GL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SH3GL3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P084115:  view genomic region     (about GC identifiers)

Start:
 84,115,980 bp from pter      End:
 84,287,495 bp from pter
Size:
 171,516 bases      Orientation:
 plus strand

Proteins
for SH3GL3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SH3G3_HUMAN, Q99963 (See protein sequence)
Recommended Name: Endophilin-A3  
Size: 347 amino acids; 39285 Da
Subunit: Interacts with ARC (By similarity). Interacts with DNM1, SGIP1 and SYNJ1. Interacts with the huntingtin exon 1
protein (HDEX1P) containing a glutamine repeat in the pathological range and promotes formation of insoluble
polyglutamine-containing aggregates in vivo. Interacts with DYDC1. Interacts with FASLG. Interacts with ATX2.
Interacts with BIN2
Subcellular location: Cytoplasm (By similarity). Early endosome membrane; Peripheral membrane protein (By similarity).
Note=Associated with postsynaptic endosomes in hippocampal neurons. Associated with presynaptic endosomes in olfactory
neurons (By similarity)
2 PDB 3D structures from and Proteopedia for SH3GL3:
2EW3 (3D)        2Z0V (3D)    
Secondary accessions: O43553 O43554
Alternative splicing: 4 isoforms:  Q99963-1   Q99963-2   Q99963-3   Q99963-4   

Explore the universe of human proteins at neXtProt for SH3GL3: NX_Q99963

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99963

    • SH3GL3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003018.3  
    ENSEMBL proteins: 
     ENSP00000391372   ENSP00000456249   ENSP00000320092   ENSP00000439239   ENSP00000397871  

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    Uscn Proteins for SH3GL3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0031901early endosome membrane IEA--


    SH3GL3 for ontologies           About GeneDecksing



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    Uscn Antibodies for SH3GL3
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    Uscn ELISAs and CLIAs for SH3GL3

    Protein Domains /
    Families
    for SH3GL3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SH3GL3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001452 SH3_domain
     IPR004148 BAR_dom

    Graphical View of Domain Structure for InterPro Entry Q99963

    ProtoNet protein and cluster: Q99963

    1 Blocks protein family: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: SH3G3_HUMAN, Q99963
    Domain: An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR
    domain (N-BAR domain) induce membrane curvature and bind curved membranes (By similarity)
    Similarity: Belongs to the endophilin family
    Similarity: Contains 1 BAR domain
    Similarity: Contains 1 SH3 domain


    Function
    for SH3GL3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SH3G3_HUMAN, Q99963
    Function: Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity)

         Genatlas biochemistry entry for SH3GL3:
    Src-homology 3 domain GRB2-like gene 3,expressed in brain and testis

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16713569
    GO:0008289lipid binding IEA--
    GO:0019904protein domain specific binding IEA--
    GO:0042802identical protein binding IPI16115810


    SH3GL3 for ontologies           About GeneDecksing



    Pathways & Interactions
    for SH3GL3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Endocytosis
    		Endocytosis1.00
    2EGFR1 Signaling Pathway
    		EGFR1 Signaling Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for SH3GL3 
        EGFR1 Signaling Pathway


    1         Kegg Pathway  (Kegg details for SH3GL3):
        Endocytosis


    SH3GL3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SH3GL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/90 Interacting proteins for SH3GL3 (Q999631, 2, 3 ENSP000003913724) via UniProtKB, MINT, STRING, and/or I2D (see all 90)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HTTP428581, 2, 3, ENSP000003471844EBI-473910,EBI-466029 MINT-7101514 MINT-7101421 MINT-3978011 MINT-7101561 MINT-3978450 MINT-7101535 MINT-7101548 MINT-3978571 I2D: score=5 STRING: ENSP00000347184
    ATXN2Q997001, 2, 3, ENSP000003668434EBI-473910,EBI-697691 MINT-7310089 MINT-2863161 MINT-2863142 MINT-7310056 MINT-7310016 MINT-7310071 I2D: score=3 STRING: ENSP00000366843
    SH3GL1Q999611, 2, 3, ENSP000002698864EBI-473910,EBI-697911 MINT-8270363 I2D: score=5 STRING: ENSP00000269886
    SH3KBP1Q96B972, 3, ENSP000003809214MINT-15312 MINT-15311 MINT-15313 MINT-8270671 I2D: score=4 STRING: ENSP00000380921
    SNX24Q9Y3432, 3, ENSP000002613694MINT-65814 I2D: score=4 STRING: ENSP00000261369
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0007165signal transduction TAS9169142
    GO:0007417central nervous system development TAS9169142


    SH3GL3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SH3GL3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SH3GL3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SH3GL3
    1 Novoseek chemical compound relationship for SH3GL3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamine 44 2 14715959 (1), 9809064 (1)

    Search CenterWatch for drugs/clinical trials and news about SH3GL3 / SH3G3 

    Transcripts
    for SH3GL3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SH3GL3 gene: 
    NM_003027.3  

    Unigene Clusters for SH3GL3:

    SH3-domain GRB2-like 3
    Hs.270055  [show with all ESTs], Hs.666365
    Unigene Representative Sequences: NM_003027, AF036272
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000492099(uc010bms.2) ENST00000427482(uc010uot.1 uc002bjw.3 uc002bjx.3)
    ENST00000563901 ENST00000324537(uc002bju.3) ENST00000564054 ENST00000467735
    ENST00000535412(uc002bjv.3) ENST00000434347

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    SwitchGear 3'UTR luciferase reporter plasmid: SH3GL3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SH3GL3 (see all 7)
    OriGene shRNA RFP: SH3GL3
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SH3GL3
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SH3GL3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SH3GL3

    Additional cDNA sequence: AF036272.1 

    8 DOTS entries:

    DT.91742599  DT.455415  DT.95375812  DT.100749469  DT.431276  DT.100749468  DT.121066402  DT.75176880 

    24/52 AceView cDNA sequences (see all 52):

    AF036271 BC035598 BX108620 NM_003027 AI217188 BP367004 CF455689 AA400405 
    F10038 AF036270 BI597342 BI545363 BI599045 AA432226 BI668418 AI336437 
    BI547720 AI333036 AF036269 BC042864 X99664 AL109775 T05714 F12421 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SH3GL3    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                                        -                                         -               
    SP2:                          -     -     -                 -                                                         
    SP3:                          -     -     -                 -                                         -               
    SP4:                          -     -     -                 -     -                                   -               
    SP5:                          -     -     -                                                                           


    ECgene alternative splicing isoforms for SH3GL3

    Expression
    for SH3GL3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SH3GL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CATTTTGGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SH3GL3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Ventral/hypothalamic-like neurons (Generation of midbra...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SH3GL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SH3GL3

    SOURCE GeneReport for Unigene clusters: Hs.270055 Hs.666365

    UniProtKB/Swiss-Prot: SH3G3_HUMAN, Q99963
    Tissue specificity: Brain and testis

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    In Situ
    Assay Products:     
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    Orthologs
    for SH3GL3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SH3GL3 gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SH3GL31 SH3-domain GRB2-like 3 78.67(n)
    83.86(a)    		   395201  NM_204528.1  NP_989859.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SH3GL36
    		 --
    		 65(a)
    		 1 ↔ 1
    		 GL344365.1(514-5528)
    zebrafish
    (Danio rerio)    		 Actinopterygii sh3gl3a1 SH3-domain GRB2-like 3a 71.95(n)
    78.39(a)    		   571626  NM_001081691.2  NP_001075160.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta endoA1 , 3 synaptic vesicle endocytosis
    lysophosphatidic more3
    endophilin A1    		 49(a)3
    56.98(n)1
    55.23(a)1    		   91D43
    422651  NM_138767.21  NP_620122.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea T04D1.33   -- 50(a)   I(4675134-4676809)   --


    ENSEMBL Gene Tree for SH3GL3 (if available)
    TreeFam Gene Tree for SH3GL3 (if available) 

    Paralogs
    for SH3GL3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SH3GL3 gene
    SH3GL12  SH3GLB12  SH3GL22  SH3GLB22  
    3 SIMAP similar genes for SH3GL3 using alignment to 3 protein entries:     SH3G3_HUMAN (see all proteins):
    SH3GL2    DKFZp686B23205    SH3GL1

    SH3GL3 for paralogs           About GeneDecksing



    Genomic Variants
    for SH3GL3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2553 NCBI SNPs in SH3GL3 are shown (see all 2553)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1411645701,2
    		--84114207(+) GTAGCA/GATGAT 2 -- us2k10--------
    rs1923046761,2
    		--84114267(+) AATAAA/GTCTAT 2 -- us2k10--------
    rs727583911,2
    		C,F,--84114419(+) AGAAAC/TTTGAA 2 -- us2k12Minor allele frequency- T:0.11WA NA 238
    rs1849992241,2
    		--84114428(+) AATGTA/GCTAAC 2 -- us2k10--------
    rs1871154771,2
    		--84114429(+) ATGTAC/GTAACG 2 -- us2k10--------
    rs1922357291,2
    		--84114455(+) CCAATA/TAACTG 2 -- us2k10--------
    rs1844342341,2
    		--84114503(+) AGAGCC/TGGATT 2 -- us2k10--------
    rs1116937961,2
    		--84114669(+) GCCTGC/TGGTGA 2 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs20551441,2
    		C,A,H,--84114698(-) ACAGTC/TCAAAT 2 -- us2k117Minor allele frequency- T:0.00NS EA NA WA CSA 792
    rs1451430911,2
    		--84114803(+) AAGCCC/TACAAC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SH3GL3 (84115980 - 84287495 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SH3GL3
         2 Indels: 41658 61470

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    Disorders / Diseases
    for SH3GL3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SH3GL3 for disorders           About GeneDecksing

    OMIM gene information: 603362    OMIM disorders: --

    9 diseases for SH3GL3:    About MalaCards
    wiskott-aldrich syndrome    oral cavity cancer    cerebellar ataxia    huntington's disease
    gout    ataxia    twinning    leukemia
    neuronitis

    1 Novoseek disease relationship for SH3GL3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    huntington disease 65.7 1 9878254 (1)

    Human Genome Epidemiology (HuGE) Navigator: SH3GL3 (2 documents)

    Export disorders for SH3GL3 gene to outside databases

    Publications
    for SH3GL3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SH3GL3 gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with SH3GL3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel SH3-containing human gene family preferentially expressed in the central nervous system. (PubMed id 9169142)1, 2, 3 Giachino C....Migone N. (1997)
    2. SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates. (PubMed id 9809064)1, 2, 9 Sittler A.... Wanker E.E. (1998)
    3. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M....Janssen O. (2009)
    4. Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking. (PubMed id 18602463)1, 2 Nonis D....Auburger G. (2008)
    5. Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance. (PubMed id 15919751)1, 2 Trevaskis J.... Collier G.R. (2005)
    6. The SH3 domains of endophilin and amphiphysin bind to the proline- rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity. (PubMed id 10542231)1, 2 Cestra G.... Cesareni G. (1999)
    7. Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins. (PubMed id 10816441)1, 9 So C.W....Chan L.C. (2000)
    8. Interaction of SH3P13 and DYDC1 protein: a germ cell component that regulates acrosome biogenesis during spermiogenesis. (PubMed id 19545932)2, 9 Li S.... Wang L. (2009)
    9. LRRK2 controls an EndoA phosphorylation cycle in synap tic endocytosis. (PubMed id 22998870)1 Matta S....Verstreken P. (2012)
    10. Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis. (PubMed id 23285027)2 Sanchez-Barrena M.J.... McMahon H.T. (2012)

    External Searches for SH3GL3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SH3GL3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6457 HGNC: 10832 AceView: SH3GL3 Ensembl:ENSG00000140600 euGenes: HUgn6457
    ECgene: SH3GL3 Kegg: 6457 H-InvDB: SH3GL3

    Other Databases showing SH3GL3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SH3GL3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SH3GL3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SH3GL3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SH3GL3 gene:
    Search GeneIP for patents involving SH3GL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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