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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SH3GL2 Gene

protein-coding GIFtS: 61
GCID: GC09P017569

SH3-domain GRB2-like 2

Explore 11 diseases affiliated with
SH3GL2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
SH3-Domain GRB2-Like 2¹ ²		SH3 Domain-Containing GRB2-Like Protein 2² ³
CNSA2¹ ² ³		BA335L15.1 (SH3-Domain GRB2-Like 2)²
EEN-B1¹ ² ³		Endophilin A1 BAR Domain²
SH3D2A¹ ² ³		Endophilin-1³
SH3P4¹ ² ⁵		Endophilin-A1¹
SH3 Domain Protein 2A² ³		Endophilin-1³

External Ids:	HGNC: 10831¹	Entrez Gene: 6456²	Ensembl: ENSG00000107295⁷	OMIM: 604465⁵	UniProtKB: Q99962³

Export aliases for SH3GL2 gene to outside databases

Previous GC identifer: GC09P017744

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SH3G2_HUMAN, Q99962

Function: Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature

Gene Wiki entry for SH3GL2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008413.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SH3GL2 gene promoter:
Nkx3-1 Nkx3-1 v4 Nkx3-1 v1 NF-kappaB AREB6 Nkx3-1 v2 RORalpha1 NF-kappaB2 Nkx3-1 v3 NF-kappaB1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for SH3GL2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH3GL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22 Ensembl cytogenetic band: 9p22.2 HGNC cytogenetic band: 9p22

SH3GL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SH3GL2 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P017569: view genomic region (about GC identifiers)

Start:	17,578,953 bp from pter	End:	17,797,127 bp from pter
Size:	218,175 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SH3G2_HUMAN, Q99962 (See protein sequence)

Recommended Name: Endophilin-A1

Size: 352 amino acids; 39962 Da

Subunit: Monomer; in cytoplasm. Homodimer; when associated with membranes (By similarity). Interacts with OPHN1 (By

similarity). Interacts with SYNJ1 and DNM1. Interacts with MAP4K3; the interaction appears to regulate MAP4K3-mediated

JNK activation. Interacts with PDCD6IP. Interacts with ATX2. Interacts with ADAM9 and ADAM15 cytoplasmic tails.

Interacts with BIN2

Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Note=Concentrated in presynaptic nerve

terminals in neurons

Miscellaneous: HeLa cells expressing the N-BAR domain of SH3GL2 show tubulation of the plasma membrane. The N-BAR

domain binds liposomes and induces formation of tubules from liposomes. The N-terminal amphipathic helix is required

for liposome binding. The second amphipathic helix enhances liposome tubulation

4 PDB 3D structures from and Proteopedia for SH3GL2:

1X03 (3D)

1X04 (3D)

2D4C (3D)

2DBM (3D)

Secondary accessions: B2R618 Q9NQK5

Explore the universe of human proteins at neXtProt for SH3GL2: NX_Q99962

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q99962

SH3GL2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003017.1

ENSEMBL proteins:

ENSP00000369981 ENSP00000443365

Reactome Protein details: Q99962
Human Recombinant Protein Products:

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	ProSpec Recombinant Protein for SH3GL2
	Uscn Proteins for SH3GL2

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	TAS	--
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	TAS	--
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	--

SH3GL2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SH3GL2 for domains About GeneDecksing

4 InterPro domains/families:

IPR013315 Spectrin_alpha_SH3

IPR011511 SH3_2

IPR001452 SH3_domain

IPR004148 BAR_dom

Graphical View of Domain Structure for InterPro Entry Q99962

ProtoNet protein and cluster: Q99962

1 Blocks protein family: IPB001452 SH3 domain signature

UniProtKB/Swiss-Prot: SH3G2_HUMAN, Q99962

Domain: An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR

domain (N-BAR domain) induce membrane curvature and bind curved membranes. The BAR domain dimer forms a rigid crescent

shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface

Similarity: Belongs to the endophilin family

Similarity: Contains 1 BAR domain

Similarity: Contains 1 SH3 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SH3G2_HUMAN, Q99962

Function: Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature

Genatlas biochemistry entry for SH3GL2:

Src-homology 3 domain GRB2-like gene 2,expressed in the brain

miRNA Products:		OriGene 3'-UTR Clone: SH3GL2 Browse MicroRNA Expression Plasmids
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		hsa-miR-362-3p hsa-miR-448 hsa-miR-146a hsa-miR-15a hsa-miR-4299 hsa-miR-103a hsa-miR-424 hsa-miR-133a

		SwitchGear 3'UTR luciferase reporter plasmid: SH3GL2 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3GL2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	10531379
GO:0008289	lipid binding	IEA	--
GO:0019904	protein domain specific binding	IEA	--
GO:0042802	identical protein binding	IPI	16115810

SH3GL2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SH3GL2:

Decreased circadian period len

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Axon guidance

Axon guidance	1.00	Recycling pathway of L1	0.15
Developmental Biology	0.69	Signal transduction by L1	0.12
L1CAM interactions	0.39

Clathrin derived vesicle budding

	Clathrin derived vesicle budding	1.00			Golgi Associated Vesicle Biogenesis	0.89
	trans-Golgi Network Vesicle Budding	1.00			Lysosome Vesicle Biogenesis	0.39

Signaling by FGFR

	Signaling by EGFR	0.84			NGF signalling via TRKA from the plasma membrane	0.70
	Signaling by EGFR in Cancer	0.83			Signalling by NGF	0.52

Transport of MHC II:Ii complex along Golgi to TGN

	Internalization of MHC II:Ii clathrin coated vesicle	0.52			Retrograde neurotrophin signalling	0.00
	EGFR downregulation	0.00

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Pathway sources
See GeneCards unified pathways
Show all pathways

4 BioSystems Pathways for SH3GL2

	EGFR1 Signaling Pathway
	Internalization of ErbB1
	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
	RhoA signaling pathway

5/22 Reactome Pathways for SH3GL2 (see all 22)

	L1CAM interactions
	Developmental Biology
	Internalization of MHC II:Ii clathrin coated vesicle
	Membrane Trafficking
	Clathrin derived vesicle budding

1 Kegg Pathway (Kegg details for SH3GL2):

Endocytosis

SH3GL2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SH3GL2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/146 Interacting proteins for SH3GL2 (Q99962^{1, 2, 3} ENSP00000369981⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 146)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATXN2	Q99700¹^,²^,³, ENSP00000366843⁴	EBI-77938,EBI-697691 MINT-7310170 MINT-7310032 MINT-7309999 MINT-7310105 MINT-7310152 I2D: score=4 STRING: ENSP00000366843
SH3KBP1	Q96B97²^,³, ENSP00000380921⁴	MINT-6170185 MINT-6170213 MINT-6170139 MINT-8270583 MINT-6170229 MINT-6170513 I2D: score=4 STRING: ENSP00000380921
ITCH	Q96J02²^,³, ENSP00000363998⁴	MINT-19901 MINT-19904 MINT-19902 I2D: score=4 STRING: ENSP00000363998
SYNJ1	O43426²^,³, ENSP00000322234⁴	MINT-16185 MINT-16186 I2D: score=5 STRING: ENSP00000322234
SH3GL1	Q99961²^,³, ENSP00000269886⁴	MINT-8270561 I2D: score=3 STRING: ENSP00000269886

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002090	regulation of receptor internalization	IEA	--
GO:0006892	post-Golgi vesicle-mediated transport	TAS	--
GO:0007165	signal transduction	TAS	9169142
GO:0007173	epidermal growth factor receptor signaling pathway	TAS	--
GO:0007411	axon guidance	TAS	--

SH3GL2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SH3GL2
Search CenterWatch for drugs/clinical trials and news about SH3GL2 / SH3G2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SH3GL2 gene:

NM_003026.2

Unigene Cluster for SH3GL2:

SH3-domain GRB2-like 2

Hs.75149 [show with all ESTs]

Unigene Representative Sequence: NM_003026

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000467085 ENST00000380607(uc003zna.3 uc011lmy.2) ENST00000537391(uc011lmx.1)

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		hsa-miR-362-3p hsa-miR-448 hsa-miR-146a hsa-miR-15a hsa-miR-4299 hsa-miR-103a hsa-miR-424 hsa-miR-133a

		SwitchGear 3'UTR luciferase reporter plasmid: SH3GL2 3' UTR sequence

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Additional cDNA sequence:

AB206840.1 AF036268.1 AK057744.1 AK293546.1 AK293592.1 AK302273.1 AK302572.1 AK312400.1

BC032825.2 BT019682.1 BX538074.1 CR542086.1 CR542102.1 X99657.1

10 DOTS entries:

DT.112496 DT.101981118 DT.91684589 DT.121147108 DT.100774774 DT.121147110 DT.95371106 DT.100774775

DT.121147109 DT.95212463

24/72 AceView cDNA sequences (see all 72):

CR601861 BP349111 CR542102 CD108610 BI919260 BI755396 CR542086 CD242702

BM450966 BQ268249 CA774631 AA429114 AW197452 AL538081 BX282149 CK003551

BG402835 AL539288 BM925595 AL134218 X99657 BP361479 AI633882 CK905999

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SH3GL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGAGTGAAA

About this image

SH3GL2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SH3GL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SH3GL2

SOURCE GeneReport for Unigene cluster: Hs.75149

UniProtKB/Swiss-Prot: SH3G2_HUMAN, Q99962

Tissue specificity: Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum

SABiosciences Custom PCR Arrays for SH3GL2

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3GL2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SH3GL2 gene from 6/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SH3GL2¹	SH3-domain GRB2-like 2	84.75(n) 90.62(a)		395203 NM_204530.1 NP_989861.1
lizard (Anolis carolinensis)	Reptilia	-- --	--	87(a) 79(a)	1 ↔ many 1 ↔ many	2(36488160-36521656) GL344668.1(644-22183)
African clawed frog (Xenopus laevis)	Amphibia	Xl.5796²	Xenopus laevis transcribed sequence with moderate similarity more	79.32(n)		BX847052.1
zebrafish (Danio rerio)	Actinopterygii	zgc55616²	similar to SH3-domain GRB2-like 2	75.93(n)		394091 BC044199.1
fruit fly (Drosophila melanogaster)	Insecta	endoA³	synaptic vesicle endocytosis lysophosphatidic more	48(a)		91D4 --
worm (Caenorhabditis elegans)	Secernentea	T04D1.3³	--	47(a)		I(4675134-4676809) --

ENSEMBL Gene Tree for SH3GL2 (if available)
TreeFam Gene Tree for SH3GL2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SH3GL2 gene

SH3GL3² SH3GL1² SH3GLB1² SH3GLB2²

18/82 SIMAP similar genes for SH3GL2 using alignment to 7 protein entries: SH3G2_HUMAN (see all proteins) (see all similar genes):

DKFZp686B23205 SH3GL1 SH3GL3 RUTBC3 SGSM3 ABI-2

ABI2 VAV1 argBPIB SH3KBP1 CD2AP SH3RF3

SORBS2 ITSN1 SH3RF1 NEBL OSTF1 GRB2

SH3GL2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10963153^1,2	C,F,	--	17551698(+)	`ATCAGT/GTTTTT`	1	--	int¹ trp³		4		NA	126
rs58580898^1,2	C,F,	--	17551717(+)	`GTGGCA/CCCGTT`	1	--	int¹		3		WA CSA	122
rs3780250^1,2	H	--	17552082(-)	`GTTACG/AGGGCC`	1	--	int¹		3		EA NS	298
rs75865988^1,2	F,	--	17552544(+)	`CATCAT/GCATCG`	1	--	int¹		1		WA	118
rs73641993^1,2	C,	--	17552681(+)	`TTAAGT/CTCTGT`	1	--	int¹		2		WA	120
rs78167536^1,2	C,	--	17581242(+)	`CGCCC-/TATAAAG`	1	--	int¹		0	--	--	--	--
rs3840725^1,2	C,	--	17582278(-)	`TCAAT-/CAAT TTTTG`	1	--	int¹		0	--	--	--	--
rs10541248^1,2	C	--	17582280(+)	`TTGAT-/TGAT CATCT`	1	--	int¹		1		NA	2
rs3837232^1,2	C,	--	17602785(-)	`ATAGA-/AGTCCT`	1	--	int¹		1		NA	2
rs3084595^1,2	C	--	17604976(+)	`AGTCA-/TTTTTTT`	1	--	int¹		2		NA CSA	4

HapMap Linkage Disequilibrium report for SH3GL2 (17578953 - 17797127 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for SH3GL2
9 CNVs: 34499 52765 53227 52764 70528 5260 52762 65348 8622

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SH3GL2 for disorders           About GeneDecksing

OMIM gene information: 604465    OMIM disorders: --

11 diseases for SH3GL2:    About MalaCards

juvenile astrocytoma pandas laryngitis multiple sclerosis

laryngeal carcinoma breast carcinoma ataxia carcinoma

schizophrenia leukemia neuronitis

Human Genome Epidemiology (HuGE) Navigator: SH3GL2 (3 documents)

Export disorders for SH3GL2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SH3GL2 gene, integrated from 9 sources (see all 72):
(articles sorted by number of sources associating them with SH3GL2)

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A novel SH3-containing human gene family preferentially expressed in the central nervous system. (PubMed id 9169142)^{1, 2, 3} Giachino C....Migone N. (1997)
Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking. (PubMed id 18602463)^{1, 2} Nonis D....Auburger G. (2008)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
The SH3 domains of endophilin and amphiphysin bind to the proline- rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity. (PubMed id 10542231)^{1, 2} Cestra G.... Cesareni G. (1999)
Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1. (PubMed id 10531379)^{1, 2} Howard L.... Blobel C.P. (1999)
SH3GL2 gene participates in MEK-ERK signal pathway pa rtly by regulating EGFR in the laryngeal carcinoma cell line Hep2. (PubMed id 20512084)^{1, 9} Shang C....Sun K. (2010)
Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate. (PubMed id 11877424)^{1, 9} Chen-Hwang M.C....Hwang Y.W. (2002)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Meta-analysis of Parkinson's disease: identification o f a novel locus, RIT2. (PubMed id 22451204)¹ Pankratz N....Foroud T. (2012)
Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis. (PubMed id 23285027)² Sanchez-Barrena M.J.... McMahon H.T. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6456	HGNC: 10831	AceView: SH3GL2	Ensembl:ENSG00000107295	euGenes: HUgn6456
ECgene: SH3GL2	Kegg: 6456	H-InvDB: SH3GL2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SH3GL2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SH3GL2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SH3GL2 gene:
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