Aliases for SH3GL1 Gene
External Ids for SH3GL1 Gene
Previous GeneCards Identifiers for SH3GL1 Gene
This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for SH3GL1 Gene
SH3GL1 (SH3-Domain GRB2-Like 1) is a Protein Coding gene. Diseases associated with SH3GL1 include clear cell hidradenoma and lymphoid leukemia. Among its related pathways are Endocytosis and Signaling events mediated by focal adhesion kinase. GO annotations related to this gene include identical protein binding and phosphatase binding. An important paralog of this gene is SH3GLB2.
UniProtKB/Swiss-Prot for SH3GL1 Gene
Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).