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Aliases for SH3D21 Gene

Aliases for SH3D21 Gene

  • SH3 Domain Containing 21 2 3 5
  • C1orf113 3 4
  • SH3 Domain-Containing Protein C1orf113 3
  • Chromosome 1 Open Reading Frame 113 2
  • SH3 Domain-Containing Protein 21 3

External Ids for SH3D21 Gene

Previous HGNC Symbols for SH3D21 Gene

  • C1orf113

Previous GeneCards Identifiers for SH3D21 Gene

  • GC01P036772

Summaries for SH3D21 Gene

GeneCards Summary for SH3D21 Gene

SH3D21 (SH3 Domain Containing 21) is a Protein Coding gene. An important paralog of this gene is SH3KBP1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3D21 Gene

Genomics for SH3D21 Gene

Regulatory Elements for SH3D21 Gene

Enhancers for SH3D21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G036339 1.3 Ensembl ENCODE dbSUPER 18.4 +36.7 36726 6.8 RB1 ZNF473 ARID4B ZNF48 RAD21 GATA2 ZNF366 SCRT2 ZNF143 FOS SH3D21 ENSG00000201448 OSCP1 LSM10 RNU4-27P TRAPPC3 MAP7D1 ENSG00000116883 PIR56403 PIR49451
GH01G036385 1.4 ENCODE dbSUPER 16.8 +82.4 82408 7.8 MLX AGO1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF263 SP3 NFYC EVA1B THRAP3 LOC105378647 ENSG00000116883 SH3D21 ENSG00000201448 OSCP1 TRAPPC3 STK40 LSM10
GH01G036358 1.5 FANTOM5 ENCODE dbSUPER 13.3 +54.2 54214 2.1 HDAC1 ATF1 ZNF121 EGR1 SCRT2 CEBPB NFIC SMARCA4 ZSCAN16 IKZF1 CSF3R SH3D21 ENSG00000116883 EVA1B ENSG00000201448 OSCP1 LSM10 RNU4-27P THRAP3 STK40
GH01G036169 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -131.1 -131079 10.1 BCOR CTCF MXI1 PTBP1 JUN ZSCAN4 ZMYM3 RBBP5 BMI1 ZIC2 MAP7D1 ENSG00000116883 COL8A2 ADPRHL2 LOC100128093 TEKT2 SH3D21 EVA1B LSM10 RNU4-27P
GH01G036237 1.5 Ensembl ENCODE dbSUPER 10.8 -66.3 -66253 3.8 PKNOX1 FOXA2 MLX ARID4B DMAP1 ZNF2 ZNF143 KLF13 DEK PAF1 ENSG00000116883 COL8A2 TRAPPC3 MAP7D1 SH3D21 EVA1B ADPRHL2 TEKT2 LOC100128093 ENSG00000201448
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SH3D21 on UCSC Golden Path with GeneCards custom track

Promoters for SH3D21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000004791 1074 1201 HDGF PKNOX1 MLX ARNT ARID4B DMAP1 ZNF2 SLC30A9 SP3 SP5

Genomic Location for SH3D21 Gene

Chromosome:
1
Start:
36,305,726 bp from pter
End:
36,324,886 bp from pter
Size:
19,161 bases
Orientation:
Plus strand

Genomic View for SH3D21 Gene

Genes around SH3D21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3D21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3D21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3D21 Gene

Proteins for SH3D21 Gene

  • Protein details for SH3D21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4FU49-SH321_HUMAN
    Recommended name:
    SH3 domain-containing protein 21
    Protein Accession:
    A4FU49
    Secondary Accessions:
    • B4DLI6
    • D3DPS6
    • J3KQM5
    • Q5VTK7
    • Q86XZ6
    • Q8N445
    • Q96DN4
    • Q9H5W5

    Protein attributes for SH3D21 Gene

    Size:
    640 amino acids
    Molecular mass:
    70519 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI01677.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAI01679.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAB15504.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB71191.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=CAH71860.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAX07375.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAX07376.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SH3D21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH3D21 Gene

Post-translational modifications for SH3D21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SH3D21 Gene

Domains & Families for SH3D21 Gene

Protein Domains for SH3D21 Gene

Suggested Antigen Peptide Sequences for SH3D21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SH3D21: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SH3D21 Gene

Function for SH3D21 Gene

Animal Model Products

miRNA for SH3D21 Gene

miRTarBase miRNAs that target SH3D21

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH3D21 Gene

Localization for SH3D21 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH3D21 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SH3D21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SH3D21: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SH3D21 Gene

Pathways & Interactions for SH3D21 Gene

SuperPathways for SH3D21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SH3D21 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SH3D21 Gene

Drugs & Compounds for SH3D21 Gene

No Compound Related Data Available

Transcripts for SH3D21 Gene

Unigene Clusters for SH3D21 Gene

SH3 domain containing 21:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3D21 Gene

No ASD Table

Relevant External Links for SH3D21 Gene

GeneLoc Exon Structure for
SH3D21
ECgene alternative splicing isoforms for
SH3D21

Expression for SH3D21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SH3D21 Gene

mRNA differential expression in normal tissues according to GTEx for SH3D21 Gene

This gene is overexpressed in Thyroid (x6.1), Skin - Not Sun Exposed (Suprapubic) (x4.5), and Skin - Sun Exposed (Lower leg) (x4.0).

Protein differential expression in normal tissues from HIPED for SH3D21 Gene

This gene is overexpressed in Liver (64.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SH3D21 Gene



Protein tissue co-expression partners for SH3D21 Gene

NURSA nuclear receptor signaling pathways regulating expression of SH3D21 Gene:

SH3D21

SOURCE GeneReport for Unigene cluster for SH3D21 Gene:

Hs.524496

Evidence on tissue expression from TISSUES for SH3D21 Gene

  • Nervous system(4.4)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with SH3D21: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SH3D21 Gene

Orthologs for SH3D21 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3D21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SH3D21 34 35
  • 99.07 (n)
dog
(Canis familiaris)
Mammalia SH3D21 34 35
  • 79.15 (n)
oppossum
(Monodelphis domestica)
Mammalia SH3D21 35
  • 76 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SH3D21 34 35
  • 75.72 (n)
mouse
(Mus musculus)
Mammalia Sh3d21 34 16 35
  • 71.2 (n)
rat
(Rattus norvegicus)
Mammalia Sh3d21 34
  • 67.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 28 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia SH3D21 35
  • 23 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii SH3D21 35
  • 28 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cindr 35
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y44E3A.4 35
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
OneToMany
Species where no ortholog for SH3D21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SH3D21 Gene

ENSEMBL:
Gene Tree for SH3D21 (if available)
TreeFam:
Gene Tree for SH3D21 (if available)

Paralogs for SH3D21 Gene

Paralogs for SH3D21 Gene

(3) SIMAP similar genes for SH3D21 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SH3D21: view

Variants for SH3D21 Gene

Sequence variations from dbSNP and Humsavar for SH3D21 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000004463 -- 36,306,432(+) AAGTG(C/T)GGAGG intron-variant, upstream-variant-2KB
rs1000056539 -- 36,327,299(+) AGGTA(A/G)CTTAT intron-variant
rs1000294102 -- 36,314,678(+) CTTGA(A/G)CTCCT intron-variant
rs1000297447 -- 36,322,118(+) CCCCT(C/G/T)CCCGC intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1000429875 -- 36,321,480(+) GACGC(C/T)CGGCC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SH3D21 Gene

Variant ID Type Subtype PubMed ID
esv2758931 CNV loss 17122850
esv3585733 CNV loss 21293372
nsv1119678 CNV deletion 24896259
nsv444 CNV deletion 18451855
nsv545997 CNV loss 21841781
nsv834702 CNV loss 17160897

Variation tolerance for SH3D21 Gene

Gene Damage Index Score: 4.96; 68.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH3D21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SH3D21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3D21 Gene

Disorders for SH3D21 Gene

Relevant External Links for SH3D21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SH3D21

No disorders were found for SH3D21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3D21 Gene

Publications for SH3D21 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3 64
  5. Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS spectra. (PMID: 17924679) Yu L.R. … Veenstra T.D. (J. Proteome Res. 2007) 3 64

Products for SH3D21 Gene

Sources for SH3D21 Gene

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