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Aliases for SH3D21 Gene

Aliases for SH3D21 Gene

  • SH3 Domain Containing 21 2 3
  • C1orf113 3 4
  • SH3 Domain-Containing Protein C1orf113 3
  • Chromosome 1 Open Reading Frame 113 2
  • SH3 Domain-Containing Protein 21 3

External Ids for SH3D21 Gene

Previous HGNC Symbols for SH3D21 Gene

  • C1orf113

Previous GeneCards Identifiers for SH3D21 Gene

  • GC01P036772

Summaries for SH3D21 Gene

GeneCards Summary for SH3D21 Gene

SH3D21 (SH3 Domain Containing 21) is a Protein Coding gene. An important paralog of this gene is CD2AP.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3D21 Gene

Genomics for SH3D21 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SH3D21 Gene

36,306,288 bp from pter
36,327,943 bp from pter
21,656 bases
Plus strand

Genomic View for SH3D21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SH3D21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3D21 Gene

No data available for Regulatory Elements for SH3D21 Gene

Proteins for SH3D21 Gene

  • Protein details for SH3D21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH3 domain-containing protein 21
    Protein Accession:
    Secondary Accessions:
    • B4DLI6
    • D3DPS6
    • J3KQM5
    • Q5VTK7
    • Q86XZ6
    • Q8N445
    • Q96DN4
    • Q9H5W5

    Protein attributes for SH3D21 Gene

    640 amino acids
    Molecular mass:
    70519 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI01677.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAI01679.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAB15504.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB71191.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=CAH71860.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAX07375.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAX07376.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SH3D21 Gene


neXtProt entry for SH3D21 Gene

Proteomics data for SH3D21 Gene at MOPED

Post-translational modifications for SH3D21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH3D21 Gene

No data available for DME Specific Peptides for SH3D21 Gene

Domains for SH3D21 Gene

Protein Domains for SH3D21 Gene

Suggested Antigen Peptide Sequences for SH3D21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • A4FU49
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with SH3D21: view

No data available for Gene Families for SH3D21 Gene

Function for SH3D21 Gene

Gene Ontology (GO) - Molecular Function for SH3D21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SH3D21: view

Animal Model Products

CRISPR Products

miRNA for SH3D21 Gene

miRTarBase miRNAs that target SH3D21

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SH3D21 Gene

Localization for SH3D21 Gene

Gene Ontology (GO) - Cellular Components for SH3D21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SH3D21: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for SH3D21 Gene

Pathways for SH3D21 Gene

SuperPathways for SH3D21 Gene

No Data Available

Interacting Proteins for SH3D21 Gene

Gene Ontology (GO) - Biological Process for SH3D21 Gene


No data available for Pathways by source for SH3D21 Gene

Transcripts for SH3D21 Gene

Unigene Clusters for SH3D21 Gene

SH3 domain containing 21:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SH3D21

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SH3D21
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3D21 Gene

No ASD Table

Relevant External Links for SH3D21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH3D21 Gene

mRNA expression in normal human tissues for SH3D21 Gene

mRNA differential expression in normal tissues according to GTEx for SH3D21 Gene

This gene is overexpressed in Thyroid (6.1), Skin - Not Sun Exposed (Suprapubic) (4.5), and Skin - Sun Exposed (Lower leg) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SH3D21 Gene

SOURCE GeneReport for Unigene cluster for SH3D21 Gene Hs.524496

genes like me logo Genes that share expressions with SH3D21: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SH3D21 Gene

Orthologs for SH3D21 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3D21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SH3D21 35
  • 99.07 (n)
  • 98.14 (a)
SH3D21 36
  • 96 (a)
(Bos Taurus)
Mammalia SH3D21 35
  • 75.72 (n)
  • 64.54 (a)
SH3D21 36
  • 49 (a)
(Canis familiaris)
Mammalia SH3D21 35
  • 79.15 (n)
  • 67.97 (a)
SH3D21 36
  • 46 (a)
(Mus musculus)
Mammalia Sh3d21 35
  • 71.2 (n)
  • 58.61 (a)
Sh3d21 16
Sh3d21 36
  • 44 (a)
(Monodelphis domestica)
Mammalia SH3D21 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 28 (a)
(Rattus norvegicus)
Mammalia Sh3d21 35
  • 67.13 (n)
  • 53.85 (a)
(Anolis carolinensis)
Reptilia SH3D21 36
  • 23 (a)
(Danio rerio)
Actinopterygii SH3D21 36
  • 28 (a)
fruit fly
(Drosophila melanogaster)
Insecta cindr 36
  • 14 (a)
(Caenorhabditis elegans)
Secernentea Y44E3A.4 36
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
Species with no ortholog for SH3D21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SH3D21 Gene

Gene Tree for SH3D21 (if available)
Gene Tree for SH3D21 (if available)

Paralogs for SH3D21 Gene

Paralogs for SH3D21 Gene

Selected SIMAP similar genes for SH3D21 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SH3D21: view

Variants for SH3D21 Gene

Sequence variations from dbSNP and Humsavar for SH3D21 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1875428 -- 36,307,267(+) GAGAT(C/G)GTGGA reference, missense, utr-variant-5-prime, nc-transcript-variant
rs2282431 -- 36,319,669(+) CATCA(C/T)GGCAG intron-variant
rs2358728 -- 36,320,254(-) CGTGT(A/G)GTCCT reference, missense, nc-transcript-variant
rs2358729 -- 36,320,252(-) TGTAG(G/T)CCTCC missense, reference, nc-transcript-variant
rs2995227 -- 36,312,066(-) gcctg(A/G)gtgac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH3D21 Gene

Variant ID Type Subtype PubMed ID
dgv47e1 CNV Complex 17122850
nsv834702 CNV Loss 17160897
nsv444 CNV Loss 18451855

Relevant External Links for SH3D21 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3D21 Gene

Disorders for SH3D21 Gene

No disorders were found for SH3D21 Gene.

No data available for UniProtKB/Swiss-Prot for SH3D21 Gene

Publications for SH3D21 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  5. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3

Products for SH3D21 Gene

Sources for SH3D21 Gene

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