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Aliases for SH3D21 Gene

Aliases for SH3D21 Gene

  • SH3 Domain Containing 21 2 3 5
  • C1orf113 3 4
  • SH3 Domain-Containing Protein C1orf113 3
  • Chromosome 1 Open Reading Frame 113 2

External Ids for SH3D21 Gene

Previous HGNC Symbols for SH3D21 Gene

  • C1orf113

Previous GeneCards Identifiers for SH3D21 Gene

  • GC01P036772

Summaries for SH3D21 Gene

GeneCards Summary for SH3D21 Gene

SH3D21 (SH3 Domain Containing 21) is a Protein Coding gene. An important paralog of this gene is SH3KBP1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3D21 Gene

Genomics for SH3D21 Gene

Regulatory Elements for SH3D21 Gene

Promoters for SH3D21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SH3D21 on UCSC Golden Path with GeneCards custom track

Genomic Location for SH3D21 Gene

Chromosome:
1
Start:
36,305,726 bp from pter
End:
36,324,886 bp from pter
Size:
19,161 bases
Orientation:
Plus strand

Genomic View for SH3D21 Gene

Genes around SH3D21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3D21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3D21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3D21 Gene

Proteins for SH3D21 Gene

  • Protein details for SH3D21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4FU49-SH321_HUMAN
    Recommended name:
    SH3 domain-containing protein 21
    Protein Accession:
    A4FU49
    Secondary Accessions:
    • B4DLI6
    • D3DPS6
    • J3KQM5
    • Q5VTK7
    • Q86XZ6
    • Q8N445
    • Q96DN4
    • Q9H5W5

    Protein attributes for SH3D21 Gene

    Size:
    640 amino acids
    Molecular mass:
    70519 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI01677.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAI01679.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAB15504.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB71191.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=CAH71860.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAX07375.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAX07376.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SH3D21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH3D21 Gene

Proteomics data for SH3D21 Gene at MOPED

Post-translational modifications for SH3D21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH3D21 Gene

No data available for DME Specific Peptides for SH3D21 Gene

Domains & Families for SH3D21 Gene

Protein Domains for SH3D21 Gene

Suggested Antigen Peptide Sequences for SH3D21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A4FU49

UniProtKB/Swiss-Prot:

SH321_HUMAN :
  • Contains 1 SH3 domain.
Domain:
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with SH3D21: view

No data available for Gene Families for SH3D21 Gene

Function for SH3D21 Gene

Animal Model Products

miRNA for SH3D21 Gene

miRTarBase miRNAs that target SH3D21

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH3D21 Gene

Localization for SH3D21 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SH3D21 Gene COMPARTMENTS Subcellular localization image for SH3D21 gene
Compartment Confidence
extracellular 5
nucleus 4
cytosol 2
plasma membrane 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SH3D21 Gene

Pathways & Interactions for SH3D21 Gene

SuperPathways for SH3D21 Gene

No Data Available

Interacting Proteins for SH3D21 Gene

Gene Ontology (GO) - Biological Process for SH3D21 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SH3D21 Gene

Drugs & Compounds for SH3D21 Gene

No Compound Related Data Available

Transcripts for SH3D21 Gene

Unigene Clusters for SH3D21 Gene

SH3 domain containing 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SH3D21 Gene

No ASD Table

Relevant External Links for SH3D21 Gene

GeneLoc Exon Structure for
SH3D21
ECgene alternative splicing isoforms for
SH3D21

Expression for SH3D21 Gene

mRNA expression in normal human tissues for SH3D21 Gene

mRNA differential expression in normal tissues according to GTEx for SH3D21 Gene

This gene is overexpressed in Thyroid (x6.1), Skin - Not Sun Exposed (Suprapubic) (x4.5), and Skin - Sun Exposed (Lower leg) (x4.0).

Protein differential expression in normal tissues from HIPED for SH3D21 Gene

This gene is overexpressed in Liver (64.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SH3D21 Gene



SOURCE GeneReport for Unigene cluster for SH3D21 Gene Hs.524496

genes like me logo Genes that share expression patterns with SH3D21: view

Protein tissue co-expression partners for SH3D21 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SH3D21 Gene

Orthologs for SH3D21 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3D21 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SH3D21 35
  • 75.72 (n)
  • 64.54 (a)
SH3D21 36
  • 49 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SH3D21 35
  • 79.15 (n)
  • 67.97 (a)
SH3D21 36
  • 46 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sh3d21 35
  • 71.2 (n)
  • 58.61 (a)
Sh3d21 16
Sh3d21 36
  • 44 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SH3D21 35
  • 99.07 (n)
  • 98.14 (a)
SH3D21 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sh3d21 35
  • 67.13 (n)
  • 53.85 (a)
oppossum
(Monodelphis domestica)
Mammalia SH3D21 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 28 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia SH3D21 36
  • 23 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii SH3D21 36
  • 28 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cindr 36
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y44E3A.4 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToMany
Species with no ortholog for SH3D21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SH3D21 Gene

ENSEMBL:
Gene Tree for SH3D21 (if available)
TreeFam:
Gene Tree for SH3D21 (if available)

Paralogs for SH3D21 Gene

Paralogs for SH3D21 Gene

(3) SIMAP similar genes for SH3D21 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SH3D21: view

Variants for SH3D21 Gene

Sequence variations from dbSNP and Humsavar for SH3D21 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12121759 -, - 36,320,374(+) GGCCA(G/T)CATCC reference, missense
rs1875428 -- 36,307,267(+) GAGAT(C/G)GTGGA reference, missense, utr-variant-5-prime
rs2282431 -- 36,319,669(+) CATCA(C/T)GGCAG intron-variant
rs2358728 -- 36,320,254(-) CGTGT(A/G)GTCCT downstream-variant-500B, reference, missense
rs2358729 -- 36,320,252(-) TGTAG(G/T)CCTCC downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SH3D21 Gene

Variant ID Type Subtype PubMed ID
dgv47e1 CNV Complex 17122850
nsv834702 CNV Loss 17160897
nsv444 CNV Loss 18451855

Variation tolerance for SH3D21 Gene

Gene Damage Index Score: 4.96; 68.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH3D21 Gene

HapMap Linkage Disequilibrium report
SH3D21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3D21 Gene

Disorders for SH3D21 Gene

Relevant External Links for SH3D21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SH3D21

No disorders were found for SH3D21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3D21 Gene

Publications for SH3D21 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS spectra. (PMID: 17924679) Yu L.R. … Veenstra T.D. (J. Proteome Res. 2007) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for SH3D21 Gene

Sources for SH3D21 Gene

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