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Aliases for SH3D19 Gene

Aliases for SH3D19 Gene

  • SH3 Domain Containing 19 2 3
  • EBP 3 4 6
  • ADAM-Binding Protein Eve-1 3 4
  • EEN-Binding Protein 3 4
  • SH3 Domain-Containing Protein 19 3
  • SH3 Domain Protein D19 3
  • EEN Binding Protein 2
  • SH3P19 3
  • EVE1 3
  • Kryn 3

External Ids for SH3D19 Gene

Summaries for SH3D19 Gene

Entrez Gene Summary for SH3D19 Gene

  • This gene encodes a multiple SH3 domain-containing protein, which interacts with other proteins, such as EBP and members of ADAM family, via the SH3 domains. This protein may be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1 by EBP, and regulation of ADAM proteins in the signaling of EGFR-ligand shedding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for SH3D19 Gene

SH3D19 (SH3 Domain Containing 19) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include proline-rich region binding. An important paralog of this gene is SORBS3.

UniProtKB/Swiss-Prot for SH3D19 Gene

  • May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3D19 Gene

Genomics for SH3D19 Gene

Genomic Location for SH3D19 Gene

Start:
151,102,751 bp from pter
End:
151,325,645 bp from pter
Size:
222,895 bases
Orientation:
Minus strand

Genomic View for SH3D19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SH3D19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3D19 Gene

Regulatory Elements for SH3D19 Gene

Proteins for SH3D19 Gene

  • Protein details for SH3D19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5HYK7-SH319_HUMAN
    Recommended name:
    SH3 domain-containing protein 19
    Protein Accession:
    Q5HYK7
    Secondary Accessions:
    • B7Z296
    • Q08EK1
    • Q32N10
    • Q5U3B8
    • Q86XB3
    • Q8N5E7
    • Q9UFC8

    Protein attributes for SH3D19 Gene

    Size:
    790 amino acids
    Molecular mass:
    86525 Da
    Quaternary structure:
    • Interacts with ADAM12. Isoform 4 and isoform 5 (but not isoform 1 and isoform 2) interact with ADAM9, ADAM10, ADAM15 and ADAM17. Interacts with SH3GL1 SH3 domain. Interacts via SH3 3 and SH3 4 or SH3 4 and SH3 5 domains with SOS2. Probably forms a trimeric complex with SH3GL1 and SOS2. Interacts with SH3YL1 (By similarity).
    SequenceCaution:
    • Sequence=AAI08891.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI08892.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI08893.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI08894.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF83714.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI46052.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SH3D19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH3D19 Gene

Proteomics data for SH3D19 Gene at MOPED

Post-translational modifications for SH3D19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH3D19 Gene

No data available for DME Specific Peptides for SH3D19 Gene

Domains for SH3D19 Gene

Protein Domains for SH3D19 Gene

UniProtKB/Swiss-Prot:

SH319_HUMAN
Domain:
  • Contains 5 SH3 domains.:
    • Q5HYK7
genes like me logo Genes that share domains with SH3D19: view

No data available for Gene Families for SH3D19 Gene

Function for SH3D19 Gene

Molecular function for SH3D19 Gene

UniProtKB/Swiss-Prot Function: May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization.

Gene Ontology (GO) - Molecular Function for SH3D19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15280379
GO:0070064 proline-rich region binding IPI 15280379
genes like me logo Genes that share ontologies with SH3D19: view

miRNA for SH3D19 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SH3D19 Gene

Localization for SH3D19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH3D19 Gene

Cytoplasm. Nucleus. Note=Is recruited to the nucleus by the KMT2A/MLL1-EEN fusion protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SH3D19 Gene COMPARTMENTS Subcellular localization image for SH3D19 gene
Compartment Confidence
nucleus 5
cytosol 4
golgi apparatus 4
plasma membrane 4

Gene Ontology (GO) - Cellular Components for SH3D19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA 15280379
genes like me logo Genes that share ontologies with SH3D19: view

Pathways for SH3D19 Gene

genes like me logo Genes that share pathways with SH3D19: view

Gene Ontology (GO) - Biological Process for SH3D19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0007010 cytoskeleton organization IMP 21834987
GO:0022604 regulation of cell morphogenesis IMP 21834987
GO:0051044 positive regulation of membrane protein ectodomain proteolysis IMP 15280379
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with SH3D19: view

Transcripts for SH3D19 Gene

Unigene Clusters for SH3D19 Gene

SH3 domain containing 19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SH3D19 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - -
SP2: -
SP3:
SP4: - - - -
SP5: - -
SP6:
SP7:
SP8:

ExUns: 20 ^ 21 ^ 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for SH3D19 Gene

GeneLoc Exon Structure for
SH3D19
ECgene alternative splicing isoforms for
SH3D19

Expression for SH3D19 Gene

mRNA expression in normal human tissues for SH3D19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SH3D19 Gene

SOURCE GeneReport for Unigene cluster for SH3D19 Gene Hs.744983

mRNA Expression by UniProt/SwissProt for SH3D19 Gene

Q5HYK7-SH319_HUMAN
Tissue specificity: Widely expressed with highest levels in heart, skeletal muscle, kidney, liver, placenta, small intestine and lung. Expressed at low levels in colon, thymus, spleen and leukocytes.
genes like me logo Genes that share expressions with SH3D19: view

Orthologs for SH3D19 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SH3D19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SH3D19 36
  • 99.32 (n)
  • 98.63 (a)
SH3D19 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SH3D19 36
  • 85.14 (n)
  • 81.4 (a)
SH3D19 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SH3D19 36
  • 88.47 (n)
  • 84.66 (a)
SH3D19 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sh3d19 36
  • 82.97 (n)
  • 78.45 (a)
Sh3d19 16
Sh3d19 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SH3D19 37
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 51 (a)
OneToMany
-- 37
  • 58 (a)
OneToMany
-- 37
  • 69 (a)
OneToMany
-- 37
  • 71 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Sh3d19 36
  • 82.38 (n)
  • 77.82 (a)
chicken
(Gallus gallus)
Aves SH3D19 36
  • 66.8 (n)
  • 59.07 (a)
SH3D19 37
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SH3D19 37
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3d19 36
  • 60.21 (n)
  • 52.2 (a)
zebrafish
(Danio rerio)
Actinopterygii sh3d19 36
  • 50.55 (n)
  • 40.73 (a)
sh3d19 37
  • 25 (a)
OneToMany
sh3d19 37
  • 25 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta l(3)05822 37
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea B0303.7 37
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LSB1 39
Species with no ortholog for SH3D19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3D19 Gene

ENSEMBL:
Gene Tree for SH3D19 (if available)
TreeFam:
Gene Tree for SH3D19 (if available)

Paralogs for SH3D19 Gene

Paralogs for SH3D19 Gene

Selected SIMAP similar genes for SH3D19 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SH3D19: view

Variants for SH3D19 Gene

Sequence variations from dbSNP and Humsavar for SH3D19 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs10964 -- 151,141,869(+) AACCA(A/G)TCCTT intron-variant
rs938990 -- 151,200,184(-) atact(A/G)tagac intron-variant
rs1046126 -- 151,121,531(-) GTGAA(A/T)TCAGC utr-variant-3-prime
rs1046133 -- 151,121,511(-) CCAAA(A/T)TAATC utr-variant-3-prime
rs1046168 -- 151,120,350(-) TGTCA(C/G)CAGAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SH3D19 Gene

Variant ID Type Subtype PubMed ID
nsv526976 CNV Gain 19592680
nsv880262 CNV Gain 21882294
nsv881526 CNV Gain 21882294
esv2675418 CNV Deletion 23128226
nsv4549 CNV Insertion 18451855
esv2666673 CNV Deletion 23128226
esv1227235 CNV Insertion 17803354

Relevant External Links for SH3D19 Gene

HapMap Linkage Disequilibrium report
SH3D19

Disorders for SH3D19 Gene

No disorders were found for SH3D19 Gene.

No data available for UniProtKB/Swiss-Prot for SH3D19 Gene

Publications for SH3D19 Gene

  1. Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein. (PMID: 14551139) Yam J.W. … Chan L.C. (Blood 2004) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands. (PMID: 15280379) Tanaka M. … Higashiyama S. (J. Biol. Chem. 2004) 3 4
  4. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PMID: 21834987) Bai S.W. … Ridley A.J. (BMC Biol. 2011) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3

Products for SH3D19 Gene

Sources for SH3D19 Gene

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