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SH3D19 Gene

protein-coding   GIFtS: 49
GCID: GC04M152041

SH3 Domain Containing 19

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SH3 Domain Containing 191 2     EVE12
EBP2 3 5     Kryn2
ADAM-Binding Protein Eve-12 3     SH3P192
EEN-Binding Protein2 3     SH3 Domain Protein D192
EEN Binding Protein1     SH3 Domain-Containing Protein 192

External Ids:    HGNC: 304181   Entrez Gene: 1525032   Ensembl: ENSG000001096867   OMIM: 6086745   UniProtKB: Q5HYK73   

Export aliases for SH3D19 gene to outside databases

Previous GC identifers: GC04M152401 GC04M152260 GC04M147766


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SH3D19 Gene:
This gene encodes a multiple SH3 domain-containing protein, which interacts with other proteins, such as EBP and
members of ADAM family, via the SH3 domains. This protein may be involved in suppression of Ras-induced cellular
transformation and Ras-mediated activation of ELK1 by EBP, and regulation of ADAM proteins in the signaling of
EGFR-ligand shedding. Alternatively spliced transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for SH3D19 Gene:
SH3D19 (SH3 domain containing 19) is a protein-coding gene. GO annotations related to this gene include proline-rich region binding. An important paralog of this gene is SH3RF3.

UniProtKB/Swiss-Prot: SH319_HUMAN, Q5HYK7
Function: May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand
shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of
ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SH3D19 gene promoter:
         HFH-3   AP-1   GATA-3   MEF-2A   FOXI1   POU2F1   POU2F1a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSH3D19 promoter sequence
   Search Chromatin IP Primers for SH3D19

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SH3D19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.3   Ensembl cytogenetic band:  4q31.3   HGNC cytogenetic band: 4q31.3

SH3D19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SH3D19 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M152041:  view genomic region     (about GC identifiers)

Start:
152,023,903 bp from pter      End:
152,246,784 bp from pter
Size:
222,882 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SH319_HUMAN, Q5HYK7 (See protein sequence)
Recommended Name: SH3 domain-containing protein 19  
Size: 790 amino acids; 86525 Da
Subunit: Interacts with ADAM12. Isoform 4 and isoform 5 (but not isoform 1 and isoform 2) interact with ADAM9,
ADAM10, ADAM15 and ADAM17. Interacts with SH3GL1 SH3 domain. Interacts via SH3 3 and SH3 4 or SH3 4 and SH3 5
domains with SOS2. Probably forms a trimeric complex with SH3GL1 and SOS2. Interacts with SH3YL1 (By similarity)
Caution: It is uncertain whether Met-1 or Met-4 is the initiator
Sequence caution: Sequence=AAI08891.1; Type=Erroneous initiation; Sequence=AAI08892.1; Type=Erroneous initiation;
Sequence=AAI08893.1; Type=Erroneous initiation; Sequence=AAI08894.1; Type=Erroneous initiation;
Sequence=BAF83714.1; Type=Erroneous initiation; Sequence=CAI46052.1; Type=Erroneous initiation;
Secondary accessions: B7Z296 Q08EK1 Q32N10 Q5U3B8 Q86XB3 Q8N5E7 Q9UFC8
Alternative splicing: 5 isoforms:  Q5HYK7-1   Q5HYK7-2   Q5HYK7-3   Q5HYK7-4   Q5HYK7-5   

Explore the universe of human proteins at neXtProt for SH3D19: NX_Q5HYK7

Explore proteomics data for SH3D19 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SH3D19 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001009555.3  NP_001122395.1  NP_001122396.1  NP_001230278.1  

    ENSEMBL proteins: 
     ENSP00000387030   ENSP00000386848   ENSP00000423449   ENSP00000415694   ENSP00000302913  
     ENSP00000416708   ENSP00000404542  
    Reactome Protein details: Q5HYK7

    SH3D19 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SH3D19 

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    Search eBioscience for ELISAs for SH3D19 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001452 SH3_domain
     IPR011511 SH3_2
     IPR028505 SH3D19

    Graphical View of Domain Structure for InterPro Entry Q5HYK7

    ProtoNet protein and cluster: Q5HYK7

    2 Blocks protein domains:
    IPB000108 Neutrophil cytosol factor 2 signature
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: SH319_HUMAN, Q5HYK7
    Similarity: Contains 5 SH3 domains


    Find genes that share domains with SH3D19           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SH319_HUMAN, Q5HYK7
    Function: May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand
    shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of
    ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15280379
    GO:0070064proline-rich region binding IPI15280379
         
    Find genes that share ontologies with SH3D19           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SH3D19
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    miRNA
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    miRTarBase miRNAs that target SH3D19:
    hsa-let-7c-5p (MIRT051806), hsa-mir-183-5p (MIRT047081), hsa-mir-128-3p (MIRT045870), hsa-mir-375 (MIRT019905)

    Block miRNA regulation of human, mouse, rat SH3D19 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SH3D19 (see all 25):
    hsa-miR-25 hsa-miR-219-5p hsa-miR-301a hsa-miR-1297 hsa-miR-511 hsa-miR-4325 hsa-miR-3613-3p hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidSH3D19 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SH3D19

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    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3D19


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SH319_HUMAN, Q5HYK7: Cytoplasm. Nucleus. Note=Is recruited to the nucleus by the KMT2A/MLL1-EEN fusion protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    golgi apparatus4
    plasma membrane4

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA15280379

    Find genes that share ontologies with SH3D19           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SH3D19 About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    trans-Golgi Network Vesicle Budding0.89
    Golgi Associated Vesicle Biogenesis0.89
    Membrane Trafficking0.32


    Find genes that share SuperPaths with SH3D19           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SH3D19
        Golgi Associated Vesicle Biogenesis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SH3D19
    Interactions:

        Search GeneGlobe Interaction Network for SH3D19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SH3D19 (Q5HYK72, 3 ENSP000003029134) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADAM12O431842, 3, ENSP000003576684MINT-56613 MINT-56611 MINT-56614 MINT-56612 I2D: score=2 STRING: ENSP00000357668
    SH3YL1Q96HL83, ENSP000004041434I2D: score=3 STRING: ENSP00000404143
    ADAM15Q134443, ENSP000003494364I2D: score=1 STRING: ENSP00000349436
    SH3GL1Q999613, ENSP000002698864I2D: score=1 STRING: ENSP00000269886
    SH3GL3Q999633, ENSP000003913724I2D: score=1 STRING: ENSP00000391372
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006892post-Golgi vesicle-mediated transport TAS--
    GO:0007010cytoskeleton organization IMP--
    GO:0022604regulation of cell morphogenesis IMP--
    GO:0051044positive regulation of membrane protein ectodomain proteolysis IMP15280379
    GO:0061024membrane organization TAS--

    Find genes that share ontologies with SH3D19           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SH3D19 (SH319)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SH3D19 gene (4 alternative transcripts): 
    NM_001009555.3  NM_001128923.1  NM_001128924.1  NM_001243349.1  

    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000604922 ENST00000409598(uc003ime.2) ENST00000409252 ENST00000478503(uc003imb.2)
    ENST00000514152(uc010ipm.2) ENST00000427414 ENST00000508492 ENST00000462257
    ENST00000604030 ENST00000604440 ENST00000474743 ENST00000514013 ENST00000304527(uc010ipl.1)
    ENST00000455740 ENST00000424281(uc003imc.2)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SH3D19 (see all 25):
    hsa-miR-25 hsa-miR-219-5p hsa-miR-301a hsa-miR-1297 hsa-miR-511 hsa-miR-4325 hsa-miR-3613-3p hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidSH3D19 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): SH3D19 (NM_001128924)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH3D19
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    OriGene qSTAR qPCR primer pairs in human, mouse for SH3D19
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      QuantiTect SYBR Green Assays in human, mouse, rat SH3D19
      QuantiFast Probe-based Assays in human, mouse, rat SH3D19

    Selected AceView cDNA sequences (see all 195):

    CD673790 BU508639 AA385529 BX504483 AA359925 CD699913 AK128493 CR593109 
    W68646 BI963947 CN478737 AW009340 D31590 BC010110 AI802284 AA447454 
    BC032404 AA598669 BM831166 AA307462 BF109395 CK903666 CD675494 BM806268 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SH3D19 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:              -                                                     -     -                                         -                                       
    SP2:                                                                                                                    -                                       
    SP3:                                                                                                                                                            
    SP4:                                                                    -     -     -                                   -                                       
    SP5:              -                             -                                                                                                               

    ExUns: 20 ^ 21 ^ 22 ^ 23
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for SH3D19

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SH3D19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGTATATAT
    SH3D19 Expression
    About this image


    SH3D19 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Somite (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
     
     Endothelium (Cardiovascular System)
             Human umbilical vein endothelial cells (HUVEC)
     
     Skeletal Muscle (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
     
     Brain (Nervous System)
             Oligodendrocyte Precursor Cells Forebrain White Matter
    SH3D19 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SH3D19 Protein Expression

    UniProtKB/Swiss-Prot: SH319_HUMAN, Q5HYK7
    Tissue specificity: Widely expressed with highest levels in heart, skeletal muscle, kidney, liver, placenta, small
    intestine and lung. Expressed at low levels in colon, thymus, spleen and leukocytes

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    QuantiFast Probe-based Assays in human, mouse, rat SH3D19
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3D19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SH3D19 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sh3d191 , 5 SH3 domain protein D191, 5 82.97(n)1
    78.45(a)1
      3 (37.83 cM)5
    270591  NM_001082414.21  NP_001075883.21 
     859711095 
    chicken
    (Gallus gallus)
    Aves SH3D191 SH3 domain containing 19 66.8(n)
    59.07(a)
      422478  XM_420444.4  XP_420444.4 
    lizard
    (Anolis carolinensis)
    Reptilia SH3D196
    SH3 domain containing 19
    57(a)
    1 ↔ 1
    5(132473218-132528492)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sh3d191 SH3 domain containing 19 60.21(n)
    52.2(a)
      100486995  XM_004911139.1  XP_004911196.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sh3d191 SH3 domain containing 19 50.55(n)
    40.73(a)
      553811  NM_001020773.1  NP_001018609.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(3)058226
    lethal (3) 05822
    17(a)
    1 ↔ 1
    3R(14114579-14124606)
    worm
    (Caenorhabditis elegans)
    Secernentea B0303.76
    Protein B0303.7, isoform a
    23(a)
    1 ↔ 1
    III(8693638-8699453) WBGene00015128


    ENSEMBL Gene Tree for SH3D19 (if available)
    TreeFam Gene Tree for SH3D19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SH3D19 gene
    SH3RF32  SH3RF22  SORBS32  SORBS12  SH3RF12  SORBS22  
    5 SIMAP similar genes for SH3D19 using alignment to 2 protein entries:     SH319_HUMAN (see all proteins):
    SH3GL1    SH3GL2    GRAP2    ARHGEF7    ITSN1

    Find genes that share paralogs with SH3D19           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SH3D19 (see all 2079)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1506733381,2
    C--151825428(+) GAAAG-/TCATTC 4 -- ds50010--------
    rs1908394881,2
    --151825432(+) GTCATA/TCATCC 4 -- ds50010--------
    rs1454070831,2
    --151825521(+) TAGAGA/GTACAA 4 -- ds50010--------
    rs1464862561,2
    --151825679(+) AATTAA/GCTGGG 4 -- ds50010--------
    rs1491037081,2
    --151825697(+) GTGTGC/TGCCTG 4 -- ds50010--------
    rs1833945431,2
    --151825712(+) CCCAGA/CTACTC 4 -- ds50010--------
    rs100283241,2
    C--151825738(+) gagaaC/Tcactt 4 -- ds50010--------
    rs2021479011,2
    C--151825841(-) GGTATC/TTTTTT 4 -- ds50010--------
    rs3677273781,2
    C--151825841(+) AAAAA-/GATACC 4 -- ds50010--------
    rs10461681,2
    C,F,A,H--151825955(-) TGTCAC/GCAGAA 4 -- ut31 ese322Minor allele frequency- G:0.14NS EA NA WA CSA 1296

    HapMap Linkage Disequilibrium report for SH3D19 (152023903 - 152246784 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SH3D19:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666673CNV Deletion23128226
    esv2675418CNV Deletion23128226
    esv1227235CNV Insertion17803354
    nsv4549CNV Insertion18451855
    nsv880262CNV Gain21882294
    nsv526976CNV Gain19592680
    nsv881526CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SH3D19
    DNA2.0 Custom Variant and Variant Library Synthesis for SH3D19

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608674    OMIM disorders: --


    Find genes that share disorders with SH3D19           About GenesLikeMe


    Export disorders for SH3D19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SH3D19 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with SH3D19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands. (PubMed id 15280379)1, 2 Tanaka M.... Higashiyama S. (J. Biol. Chem. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein. (PubMed id 14551139)1, 2 Yam J.W.... Chan L.C. (Blood 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    6. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PubMed id 21834987)2 Bai S.W.... Ridley A.J. (BMC Biol. 2011)
    7. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)
    8. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    10. Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS. (PubMed id 19531213)1 Havrylov S....Redowicz M.J. (Proteome Sci 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 152503 HGNC: 30418 AceView: DKFZp434D0215 Ensembl:ENSG00000109686 euGenes: HUgn152503
    ECgene: SH3D19 H-InvDB: SH3D19

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SH3D19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SH3D19 gene:
    Search GeneIP for patents involving SH3D19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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