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Aliases for SH3BP5L Gene

Aliases for SH3BP5L Gene

  • SH3 Binding Domain Protein 5 Like 2 3 5
  • SH3BP-5-Like 3 4
  • SH3 Domain-Binding Protein 5-Like 3
  • KIAA1720 4

External Ids for SH3BP5L Gene

Previous GeneCards Identifiers for SH3BP5L Gene

  • GC01M245316
  • GC01M247071
  • GC01M249104

Summaries for SH3BP5L Gene

GeneCards Summary for SH3BP5L Gene

SH3BP5L (SH3 Binding Domain Protein 5 Like) is a Protein Coding gene. An important paralog of this gene is SH3BP5.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3BP5L Gene

Genomics for SH3BP5L Gene

Regulatory Elements for SH3BP5L Gene

Enhancers for SH3BP5L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G248871 1.6 Ensembl ENCODE dbSUPER 18.4 -46.7 -46661 3.2 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SH3BP5L PGBD2 RNU6-1205P PIR45492
GH01G248820 1.9 FANTOM5 Ensembl ENCODE dbSUPER 15.3 +1.7 1694 9.8 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SH3BP5L ENSG00000227237 ZNF692 PGBD2 RNU6-1205P RPL23AP25 MIR3124 GC01P248810
GH01G248803 1.1 Ensembl ENCODE 20.5 +21.1 21119 3.9 HDGF CBX3 RB1 ZNF48 RAD21 ZNF143 ZNF207 RELB IKZF2 CREM SH3BP5L RNU6-1205P OR2T1 GC01P248810 LOC100131533
GH01G248924 1.2 Ensembl ENCODE 10.7 -99.3 -99313 2.5 HDGF PKNOX1 ATF1 ARNT RAD21 RFX5 TCF12 ZNF143 IKZF2 CREM ZNF672 ZNF692 ENSG00000227237 PGBD2 SH3BP5L PIR45582 PIR40629 GC01P248921
GH01G248710 1.1 Ensembl 10.7 +115.5 115533 1.0 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SH3BP5L ENSG00000229255 ENSG00000276520 AHCYP8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SH3BP5L on UCSC Golden Path with GeneCards custom track

Promoters for SH3BP5L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000023265 433 1601 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for SH3BP5L Gene

Chromosome:
1
Start:
248,810,446 bp from pter
End:
248,826,633 bp from pter
Size:
16,188 bases
Orientation:
Minus strand

Genomic View for SH3BP5L Gene

Genes around SH3BP5L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3BP5L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3BP5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3BP5L Gene

Proteins for SH3BP5L Gene

  • Protein details for SH3BP5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L8J4-3BP5L_HUMAN
    Recommended name:
    SH3 domain-binding protein 5-like
    Protein Accession:
    Q7L8J4
    Secondary Accessions:
    • B4DQ94
    • Q96FI5
    • Q9BQH8
    • Q9C0E3

    Protein attributes for SH3BP5L Gene

    Size:
    393 amino acids
    Molecular mass:
    43499 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB21811.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SH3BP5L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH3BP5L Gene

Post-translational modifications for SH3BP5L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH3BP5L Gene

No data available for DME Specific Peptides for SH3BP5L Gene

Domains & Families for SH3BP5L Gene

Protein Domains for SH3BP5L Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7L8J4

UniProtKB/Swiss-Prot:

3BP5L_HUMAN :
  • Belongs to the SH3BP5 family.
Family:
  • Belongs to the SH3BP5 family.
genes like me logo Genes that share domains with SH3BP5L: view

No data available for Gene Families for SH3BP5L Gene

Function for SH3BP5L Gene

Gene Ontology (GO) - Molecular Function for SH3BP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IBA --
GO:0017124 SH3 domain binding IBA --
genes like me logo Genes that share ontologies with SH3BP5L: view
genes like me logo Genes that share phenotypes with SH3BP5L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH3BP5L Gene

Localization for SH3BP5L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH3BP5L gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SH3BP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with SH3BP5L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SH3BP5L Gene

Pathways & Interactions for SH3BP5L Gene

SuperPathways for SH3BP5L Gene

No Data Available

Interacting Proteins for SH3BP5L Gene

Gene Ontology (GO) - Biological Process for SH3BP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035556 intracellular signal transduction IBA --
GO:0061099 negative regulation of protein tyrosine kinase activity IBA --
genes like me logo Genes that share ontologies with SH3BP5L: view

No data available for Pathways by source and SIGNOR curated interactions for SH3BP5L Gene

Drugs & Compounds for SH3BP5L Gene

No Compound Related Data Available

Transcripts for SH3BP5L Gene

Unigene Clusters for SH3BP5L Gene

SH3-binding domain protein 5-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3BP5L Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
SP1: -
SP2: - - - - - -
SP3:
SP4: - - - - - - - - - - - - - -
SP5: -

Relevant External Links for SH3BP5L Gene

GeneLoc Exon Structure for
SH3BP5L
ECgene alternative splicing isoforms for
SH3BP5L

Expression for SH3BP5L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SH3BP5L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH3BP5L Gene

This gene is overexpressed in Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for SH3BP5L Gene

This gene is overexpressed in Peripheral blood mononuclear cells (31.9) and Prostate (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SH3BP5L Gene



NURSA nuclear receptor signaling pathways regulating expression of SH3BP5L Gene:

SH3BP5L

SOURCE GeneReport for Unigene cluster for SH3BP5L Gene:

Hs.298573

Evidence on tissue expression from TISSUES for SH3BP5L Gene

  • Nervous system(4.8)
  • Lung(4.3)
  • Intestine(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with SH3BP5L: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SH3BP5L Gene

Orthologs for SH3BP5L Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3BP5L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SH3BP5L 34 35
  • 99.41 (n)
mouse
(Mus musculus)
Mammalia Sh3bp5l 34 16 35
  • 86.99 (n)
rat
(Rattus norvegicus)
Mammalia Sh3bp5l 34
  • 86.82 (n)
cow
(Bos Taurus)
Mammalia SH3BP5L 34 35
  • 86.63 (n)
oppossum
(Monodelphis domestica)
Mammalia SH3BP5L 35
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SH3BP5L 34 35
  • 85.29 (n)
lizard
(Anolis carolinensis)
Reptilia SH3BP5L 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3bp5l 34
  • 66.55 (n)
zebrafish
(Danio rerio)
Actinopterygii sh3bp5lb 34 35
  • 68.05 (n)
sh3bp5la 35
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta pcs 35
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C03C10.4 35
  • 26 (a)
OneToMany
K03E6.7 35
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToOne
Species where no ortholog for SH3BP5L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3BP5L Gene

ENSEMBL:
Gene Tree for SH3BP5L (if available)
TreeFam:
Gene Tree for SH3BP5L (if available)

Paralogs for SH3BP5L Gene

Paralogs for SH3BP5L Gene

(1) SIMAP similar genes for SH3BP5L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SH3BP5L: view

Variants for SH3BP5L Gene

Sequence variations from dbSNP and Humsavar for SH3BP5L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000285507 -- 248,814,140(+) CAGCT(-/A)AAACA intron-variant
rs1000603834 -- 248,811,366(+) CACGG(C/G)CAGGC utr-variant-3-prime
rs1000808697 -- 248,811,125(+) CCTTG(A/G)CAATG utr-variant-3-prime
rs1000903703 -- 248,818,098(+) ATCCC(A/T)GCACT intron-variant, upstream-variant-2KB
rs1000977060 -- 248,827,552(+) GCAGA(C/T)GCATA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SH3BP5L Gene

Variant ID Type Subtype PubMed ID
dgv631n100 CNV gain 25217958
esv2145823 CNV deletion 18987734
esv2750832 CNV gain 17911159
esv2750835 CNV gain 17911159
nsv1009216 CNV gain 25217958
nsv5398 CNV insertion 18451855
nsv999043 CNV gain 25217958

Variation tolerance for SH3BP5L Gene

Residual Variation Intolerance Score: 13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH3BP5L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SH3BP5L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3BP5L Gene

Disorders for SH3BP5L Gene

Relevant External Links for SH3BP5L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SH3BP5L

No disorders were found for SH3BP5L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3BP5L Gene

Publications for SH3BP5L Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  4. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for SH3BP5L Gene

Sources for SH3BP5L Gene

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