Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SH3BP5L Gene

Aliases for SH3BP5L Gene

  • SH3-Binding Domain Protein 5-Like 2 3
  • SH3BP-5-Like 3 4
  • SH3 Domain-Binding Protein 5-Like 3
  • KIAA1720 4

External Ids for SH3BP5L Gene

Previous GeneCards Identifiers for SH3BP5L Gene

  • GC01M245316
  • GC01M247071
  • GC01M249104

Summaries for SH3BP5L Gene

GeneCards Summary for SH3BP5L Gene

SH3BP5L (SH3-Binding Domain Protein 5-Like) is a Protein Coding gene. An important paralog of this gene is SH3BP5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3BP5L Gene

Genomics for SH3BP5L Gene

Regulatory Elements for SH3BP5L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SH3BP5L Gene

248,810,446 bp from pter
248,826,633 bp from pter
16,188 bases
Minus strand

Genomic View for SH3BP5L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SH3BP5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3BP5L Gene

Proteins for SH3BP5L Gene

  • Protein details for SH3BP5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH3 domain-binding protein 5-like
    Protein Accession:
    Secondary Accessions:
    • B4DQ94
    • Q96FI5
    • Q9BQH8
    • Q9C0E3

    Protein attributes for SH3BP5L Gene

    393 amino acids
    Molecular mass:
    43499 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB21811.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SH3BP5L Gene


neXtProt entry for SH3BP5L Gene

Proteomics data for SH3BP5L Gene at MOPED

Post-translational modifications for SH3BP5L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH3BP5L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SH3BP5L Gene

Domains for SH3BP5L Gene

Protein Domains for SH3BP5L Gene


Graphical View of Domain Structure for InterPro Entry



  • Q7L8J4
  • Belongs to the SH3BP5 family.
genes like me logo Genes that share domains with SH3BP5L: view

No data available for Gene Families for SH3BP5L Gene

Function for SH3BP5L Gene

Phenotypes for SH3BP5L Gene

GenomeRNAi human phenotypes for SH3BP5L:
genes like me logo Genes that share phenotypes with SH3BP5L: view

Animal Model Products

CRISPR Products

miRNA for SH3BP5L Gene

miRTarBase miRNAs that target SH3BP5L

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SH3BP5L

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for SH3BP5L Gene

Localization for SH3BP5L Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SH3BP5L Gene

Pathways for SH3BP5L Gene

SuperPathways for SH3BP5L Gene

No Data Available

Gene Ontology (GO) - Biological Process for SH3BP5L Gene


No data available for Pathways by source for SH3BP5L Gene

Transcripts for SH3BP5L Gene

Unigene Clusters for SH3BP5L Gene

SH3-binding domain protein 5-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SH3BP5L

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3BP5L Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
SP1: -
SP2: - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: -

Relevant External Links for SH3BP5L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH3BP5L Gene

mRNA expression in normal human tissues for SH3BP5L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH3BP5L Gene

This gene is overexpressed in Whole Blood (4.4).

Protein differential expression in normal tissues for SH3BP5L Gene

This gene is overexpressed in Peripheral blood mononuclear cells (31.9) and Prostate (8.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SH3BP5L Gene

SOURCE GeneReport for Unigene cluster for SH3BP5L Gene Hs.298573

genes like me logo Genes that share expressions with SH3BP5L: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for SH3BP5L Gene

Orthologs for SH3BP5L Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3BP5L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SH3BP5L 35
  • 86.63 (n)
  • 92.97 (a)
SH3BP5L 36
  • 94 (a)
(Canis familiaris)
Mammalia SH3BP5L 35
  • 85.29 (n)
  • 93.62 (a)
SH3BP5L 36
  • 93 (a)
(Mus musculus)
Mammalia Sh3bp5l 35
  • 86.99 (n)
  • 94.9 (a)
Sh3bp5l 16
Sh3bp5l 36
  • 94 (a)
(Pan troglodytes)
Mammalia SH3BP5L 35
  • 99.41 (n)
  • 99.24 (a)
SH3BP5L 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Sh3bp5l 35
  • 86.82 (n)
  • 95.92 (a)
(Monodelphis domestica)
Mammalia SH3BP5L 36
  • 86 (a)
(Anolis carolinensis)
Reptilia SH3BP5L 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3bp5l 35
  • 66.55 (n)
  • 76.03 (a)
(Danio rerio)
Actinopterygii sh3bp5lb 35
  • 68.05 (n)
  • 71.88 (a)
sh3bp5la 36
  • 45 (a)
sh3bp5lb 36
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta pcs 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea C03C10.4 36
  • 26 (a)
K03E6.7 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for SH3BP5L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3BP5L Gene

Gene Tree for SH3BP5L (if available)
Gene Tree for SH3BP5L (if available)

Paralogs for SH3BP5L Gene

Paralogs for SH3BP5L Gene

Selected SIMAP similar genes for SH3BP5L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SH3BP5L: view

Variants for SH3BP5L Gene

Sequence variations from dbSNP and Humsavar for SH3BP5L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs14088 -- 248,810,645(+) GCCCA(C/T)GCATC utr-variant-3-prime
rs14851 -- 248,810,646(+) CCCAC(G/T)CATCC utr-variant-3-prime
rs1127427 -- 248,811,727(-) TCTCA(C/G)AGCCT utr-variant-3-prime
rs1139694 -- 248,810,595(-) TGGTC(A/C)CAATG utr-variant-3-prime
rs4307600 -- 248,810,964(-) GCAGG(A/G)CGGGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SH3BP5L Gene

Variant ID Type Subtype PubMed ID
esv2750832 CNV Gain 17911159
esv2750835 CNV Gain 17911159
esv2145823 CNV Deletion 18987734
nsv5398 CNV Insertion 18451855

Relevant External Links for SH3BP5L Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3BP5L Gene

Disorders for SH3BP5L Gene

No disorders were found for SH3BP5L Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SH3BP5L Gene

Publications for SH3BP5L Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SH3BP5L Gene

Sources for SH3BP5L Gene

Back to Top