SH3BP5L Gene
protein-coding GIFtS: 46
GCID: GC01M249104
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|
SH3-binding domain protein 5-like
| |
Aliases
for SH3BP5L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SH3-Binding Domain Protein 5-Like1 2 | | KIAA17201 3 | | SH3BP-5-Like1 | | SH3 Domain-Binding Protein 5-Like2 |
Export aliases for SH3BP5L gene to outside databasesPrevious GC identifers: GC01M245316 GC01M247071 |
Summaries
for SH3BP5L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SH3BP5L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032968.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SH3BP5L gene promoter:
ER-alpha Sox5 AML1a Olf-1 Nkx5-1 C/EBPalpha Evi-1 CREB deltaCREB RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for SH3BP5L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH3BP5L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q44 Ensembl cytogenetic band: 1q44 HGNC cytogenetic band: 1q44SH3BP5L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M249104: view genomic region
(about GC identifiers)
Start:
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249,104,648 bp from pter |
End:
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249,120,832 bp from pter |
Size:
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16,185 bases |
Orientation:
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minus strand |
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Proteins
for SH3BP5L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: 3BP5L_HUMAN, Q7L8J4 (See
protein sequence)Recommended Name: SH3 domain-binding protein 5-like Size: 393 amino acids; 43499 Da
Sequence caution: Sequence=BAB21811.1; Type=Erroneous initiation;
Secondary accessions: Q96FI5 Q9BQH8 Q9C0E3Explore the universe of human proteins at neXtProt for SH3BP5L: NX_Q7L8J4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7L8J4
SH3BP5L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_085148.1
ENSEMBL proteins: ENSP00000355428 ENSP00000412203
Human Recombinant Protein Products:
SH3BP5L Antibody Products:
Assay Products for SH3BP5L: |
Protein
Domains /
Families
for SH3BP5L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SH3BP5L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q7L8J4ProtoNet protein and cluster: Q7L8J4 1 Blocks protein family: IPB007940 SH3-binding 5
UniProtKB/Swiss-Prot: 3BP5L_HUMAN, Q7L8J4Similarity: Belongs to the SH3BP5 family |
Function
for SH3BP5L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH3BP5L (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH3BP5L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SH3BP5L (NM_030645) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SH3BP5L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH3BP5L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3BP5L |
1 GenomeRNAi human phenotype for SH3BP5L:
|
Pathways & Interactions
for SH3BP5L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SH3BP5L
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/15 Interacting proteins for SH3BP5L (Q7L8J42, 3 ENSP000003554284) via UniProtKB, MINT, STRING, and/or I2D (see all 15)About this table
|
Drugs & Compounds
for SH3BP5L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SH3BP5L
Search CenterWatch for drugs/clinical trials and news about SH3BP5L / 3BP5L
|
Transcripts
for SH3BP5L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SH3BP5L gene: NM_030645.1 Unigene Cluster for SH3BP5L: SH3-binding domain protein 5-like Hs.298573 [show with all ESTs]Unigene Representative Sequence: AK1258375 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000484202 ENST00000366472(uc001iew.1) ENST00000475978(uc010pzp.1 uc001iev.1)
ENST00000494837 ENST00000411742
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH3BP5L (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH3BP5L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SH3BP5L (NM_030645) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SH3BP5L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH3BP5L |
Additional cDNA sequence: AB051507.1 AK056345.1 AK056382.1 AK091164.1 AK125138.1 AK125837.1 AK298698.1 AK299713.1 AL136569.1 AY358453.1 BC010871.1 BC011962.1 BC017254.2 8 DOTS entries: DT.100693748 DT.75193328 DT.215101 DT.121331535 DT.40201699 DT.121331537 DT.95199949 DT.121331548 24/159 AceView cDNA sequences (see all 159): BG252164 BM920755 BQ188699 CO245215 BC011962 AL043516 CR624935 AA731605 AA490261 AK056345 BE503187 AI082297 BU839061 CR613756 CR606601 AA142979 AK091164 BC010871 CB217120 BC017254 BQ897661 AI806926 BQ690602 NM_030645
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for SH3BP5L About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | - | | - | | | | | | - | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | |
| SP5: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SH3BP5L
|
Expression
for SH3BP5L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SH3BP5L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SH3BP5L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SH3BP5L
SOURCE GeneReport for Unigene cluster: Hs.298573
SABiosciences Custom PCR Arrays for SH3BP5L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SH3BP5L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SH3BP5L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SH3BP5L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SH3BP5L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3BP5L |
Orthologs
for SH3BP5L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SH3BP5L gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
SH3BP5L6 |
-- |
71(a) |
1 ↔ 1 |
2(189555979-189566042) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BJ627589.12 |
-- |
77.56(n) |
|
BJ627589.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BC057413.12 |
-- |
75.54(n) |
|
BC057413.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
pcs1 |
parcas |
56.05(n)
53.47(a) |
|
36674 NM_137166.4 NP_611010.4 |
worm
(Caenorhabditis elegans) |
Secernentea |
C03C10.46K03E6.76 |
Protein K03E6.7 |
26(a)24(a) |
possible orthologpossible ortholog |
III(4096875-4098107) X(1084219-1088147) |
ENSEMBL Gene Tree for SH3BP5L (if available)
TreeFam Gene Tree for SH3BP5L (if available) |
Paralogs
for SH3BP5L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SH3BP5L gene
- SH3BP52
1 SIMAP similar gene for SH3BP5L using alignment to 3 protein entries: 3BP5L_HUMAN (see all proteins):SH3BP5
SH3BP5L for paralogs About GeneDecksing
|
Genomic Variants
for SH3BP5L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SH3BP5L (249104648 - 249120832 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SH3BP5L
2 CNVs: 8355 8354 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SH3BP5L |
|
Disorders
/ Diseases
for SH3BP5L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for SH3BP5L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SH3BP5L gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with SH3BP5L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (2000)
- A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
|
External Searches for SH3BP5L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SH3BP5L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SH3BP5L gene
(According to HUGE)
About This Section
| |
Specialized Databases showing SH3BP5L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SH3BP5L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SH3BP5L gene:
Search GeneIP for patents involving SH3BP5L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SH3BP5L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SH3BP5L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SH3BP5L | | | OriGene Protein Over-expression Lysate for SH3BP5L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SH3BP5L | | OriGene 3'-UTR Clone for SH3BP5L | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH3BP5L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH3BP5L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SH3BP5L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SH3BP5L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH3BP5L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SH3BP5L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SH3BP5L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SH3BP5L |
| |
 |  |  |  | |
| | | | Search Tocris compounds for SH3BP5L |
| |  |  |  |  | | | | |
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 | | | SH3BP5L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3BP5L |
|  |  |  | | | | ThermoFisher Antibodies for SH3BP5L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH3BP5L |
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