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Aliases for SH3BP5 Gene

Aliases for SH3BP5 Gene

  • SH3-Domain Binding Protein 5 (BTK-Associated) 2 3
  • SAB 3 4 6
  • SH3 Domain-Binding Protein That Preferentially Associates With BTK 3 4
  • SH3BP-5 3 4
  • SH3 Domain-Binding Protein 5 3
  • SH3 Binding Protein 2

External Ids for SH3BP5 Gene

Summaries for SH3BP5 Gene

GeneCards Summary for SH3BP5 Gene

SH3BP5 (SH3-Domain Binding Protein 5 (BTK-Associated)) is a Protein Coding gene. Diseases associated with SH3BP5 include bursitis. Among its related pathways are B cell receptor signaling pathway (KEGG). GO annotations related to this gene include SH3 domain binding and protein kinase inhibitor activity. An important paralog of this gene is SH3BP5L.

UniProtKB/Swiss-Prot for SH3BP5 Gene

  • Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.

Gene Wiki entry for SH3BP5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3BP5 Gene

Genomics for SH3BP5 Gene

Genomic Location for SH3BP5 Gene

15,254,353 bp from pter
15,341,394 bp from pter
87,042 bases
Minus strand

Genomic View for SH3BP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SH3BP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3BP5 Gene

Regulatory Elements for SH3BP5 Gene

Transcription factor binding sites by QIAGEN in the SH3BP5 gene promoter:

Proteins for SH3BP5 Gene

  • Protein details for SH3BP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH3 domain-binding protein 5
    Protein Accession:
    Secondary Accessions:
    • B3KQW6
    • Q5JWV9

    Protein attributes for SH3BP5 Gene

    455 amino acids
    Molecular mass:
    50425 Da
    Quaternary structure:
    • Interacts with BTK. Interacts with all isoforms of MAPK8, MAPK9, MAPK10 and MAPK12.
    • Sequence=BAA25922.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SH3BP5 Gene

    Alternative splice isoforms for SH3BP5 Gene


neXtProt entry for SH3BP5 Gene

Proteomics data for SH3BP5 Gene at MOPED

Post-translational modifications for SH3BP5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys173, Lys215, and Lys248

No data available for DME Specific Peptides for SH3BP5 Gene

Domains for SH3BP5 Gene

Protein Domains for SH3BP5 Gene



  • Belongs to the SH3BP5 family.:
    • O60239
genes like me logo Genes that share domains with SH3BP5: view

No data available for Gene Families for SH3BP5 Gene

Function for SH3BP5 Gene

Molecular function for SH3BP5 Gene

GENATLAS Biochemistry: SH3-domain binding protein 5,BTK-associated transregulator
UniProtKB/Swiss-Prot Function: Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.

Gene Ontology (GO) - Molecular Function for SH3BP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IDA 10339589
GO:0005515 protein binding IPI 9571151
GO:0017124 SH3 domain binding IBA --
genes like me logo Genes that share ontologies with SH3BP5: view

Phenotypes for SH3BP5 Gene

GenomeRNAi human phenotypes for SH3BP5:
genes like me logo Genes that share phenotypes with SH3BP5: view

miRNA for SH3BP5 Gene

miRTarBase miRNAs that target SH3BP5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SH3BP5 Gene

Localization for SH3BP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH3BP5 Gene


Subcellular locations from

Jensen Localization Image for SH3BP5 Gene COMPARTMENTS Subcellular localization image for SH3BP5 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SH3BP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9571151
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with SH3BP5: view

Pathways for SH3BP5 Gene

SuperPathways for SH3BP5 Gene

genes like me logo Genes that share pathways with SH3BP5: view

Pathways by source for SH3BP5 Gene

1 BioSystems pathway for SH3BP5 Gene

Gene Ontology (GO) - Biological Process for SH3BP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity --
GO:0007165 signal transduction TAS 9571151
GO:0035556 intracellular signal transduction IDA 10339589
GO:0061099 negative regulation of protein tyrosine kinase activity IBA --
genes like me logo Genes that share ontologies with SH3BP5: view

Compounds for SH3BP5 Gene

(2) Novoseek inferred chemical compound relationships for SH3BP5 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 49.8 9
proline 38.4 1
genes like me logo Genes that share compounds with SH3BP5: view

Transcripts for SH3BP5 Gene

Unigene Clusters for SH3BP5 Gene

SH3-domain binding protein 5 (BTK-associated):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SH3BP5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - -
SP6: - - - - - -
SP7: -
SP8: - - -

Relevant External Links for SH3BP5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH3BP5 Gene

mRNA expression in normal human tissues for SH3BP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SH3BP5 Gene

SOURCE GeneReport for Unigene cluster for SH3BP5 Gene Hs.257761

mRNA Expression by UniProt/SwissProt for SH3BP5 Gene

Tissue specificity: Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate.
genes like me logo Genes that share expressions with SH3BP5: view

Orthologs for SH3BP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3BP5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SH3BP5 36
  • 99.56 (n)
  • 100 (a)
SH3BP5 37
  • 100 (a)
(Bos Taurus)
Mammalia SH3BP5 36
  • 82.7 (n)
  • 84.41 (a)
SH3BP5 37
  • 84 (a)
(Canis familiaris)
Mammalia SH3BP5 36
  • 92.97 (n)
  • 98.04 (a)
SH3BP5 37
  • 97 (a)
(Mus musculus)
Mammalia Sh3bp5 36
  • 87.99 (n)
  • 91.43 (a)
Sh3bp5 16
Sh3bp5 37
  • 91 (a)
(Monodelphis domestica)
Mammalia SH3BP5 37
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia SH3BP5 37
  • 89 (a)
(Rattus norvegicus)
Mammalia Sh3bp5 36
  • 88.35 (n)
  • 91.65 (a)
(Gallus gallus)
Aves SH3BP5 36
  • 78.16 (n)
  • 86.6 (a)
SH3BP5 37
  • 85 (a)
(Anolis carolinensis)
Reptilia SH3BP5 37
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75731 36
sh3bp5 36
  • 73.89 (n)
  • 80.1 (a)
(Danio rerio)
Actinopterygii Dr.7417 36
sh3bp5b 36
  • 73.87 (n)
  • 79.22 (a)
sh3bp5b 37
  • 67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14408 37
  • 16 (a)
pcs 38
  • 48 (a)
Species with no ortholog for SH3BP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SH3BP5 Gene

Gene Tree for SH3BP5 (if available)
Gene Tree for SH3BP5 (if available)

Paralogs for SH3BP5 Gene

Paralogs for SH3BP5 Gene

Selected SIMAP similar genes for SH3BP5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SH3BP5: view

Variants for SH3BP5 Gene

Sequence variations from dbSNP and Humsavar for SH3BP5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs712868 -- 15,266,125(+) TCAGG(A/G)GCCTC intron-variant
rs712869 -- 15,296,193(-) TCTTC(A/T)TGAAG intron-variant
rs826422 -- 15,299,558(+) GAGAC(A/T)TCATG intron-variant
rs826423 -- 15,300,094(+) AAAGT(A/G)GAAAA intron-variant
rs826424 -- 15,304,533(+) AATCA(G/T)CTcgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH3BP5 Gene

Variant ID Type Subtype PubMed ID
nsv428413 CNV Gain 18775914
esv2724962 CNV Deletion 23290073
esv2113465 CNV Deletion 18987734
esv3951 CNV Deletion 18987735
esv2724963 CNV Deletion 23290073
dgv852e199 CNV Deletion 23128226
nsv876581 CNV Gain 21882294
nsv524536 CNV Loss 19592680
nsv834621 CNV Gain 17160897
nsv522980 CNV Loss 19592680

Relevant External Links for SH3BP5 Gene

HapMap Linkage Disequilibrium report

Disorders for SH3BP5 Gene

(1) MalaCards Diseases for SH3BP5 Gene

Search for SH3BP5 Gene in MalaCards »

(2) University of Copenhagen DISEASES for SH3BP5 Gene

(2) Novoseek inferred disease relationships for SH3BP5 Gene

Disease -log(P) Hits PubMed IDs
x-linked agammaglobulinemia 81.8 1
immunodeficiency 12.4 1

Relevant External Links for SH3BP5

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with SH3BP5: view

No data available for UniProtKB/Swiss-Prot for SH3BP5 Gene

Publications for SH3BP5 Gene

  1. Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein. (PMID: 10339589) Yamadori T. … Tsukada S. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 23
  2. Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (Btk). (PMID: 9571151) Matsushita M. … Tsukada S. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23
  3. A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria. (PMID: 12167088) Wiltshire C. … May G.H. (Biochem. J. 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Sab (SH3BP5), a novel mitochondria-localized JNK-interacting protein. (PMID: 15506969) Wiltshire C. … May G.H. (Biochem. Soc. Trans. 2004) 3 23

Products for SH3BP5 Gene

Sources for SH3BP5 Gene

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