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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SH3BP5 Gene

protein-coding   GIFtS: 58
GCID: GC03M015296

SH3-Domain Binding Protein 5 (BTK-Associated)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SH3-Domain Binding Protein 5 (BTK-Associated)1 2
SAB2 3 5
SH3BP-52 3
SH3 Domain-Binding Protein That Preferentially Associates With BTK2 3
SH3 Binding Protein1
SH3 Domain-Binding Protein 52

External Ids:    HGNC: 108271   Entrez Gene: 94672   Ensembl: ENSG000001313707   OMIM: 6056125   UniProtKB: O602393   

Export aliases for SH3BP5 gene to outside databases

Previous GC identifers: GC03M015225 GC03M015271 GC03M015231


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SH3BP5 Gene: 
SH3BP5 (SH3-domain binding protein 5 (BTK-associated)) is a protein-coding gene. Diseases associated with SH3BP5 include tabes dorsalis, and bursitis, and among its related super-pathways are B cell receptor signaling pathway. GO annotations related to this gene include protein kinase inhibitor activity and SH3 domain binding. An important paralog of this gene is SH3BP5L.

UniProtKB/Swiss-Prot: 3BP5_HUMAN, O60239
Function: Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in
BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death

Gene Wiki entry for SH3BP5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SH3BP5 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SH3BP5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SH3BP5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH3BP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.3   Ensembl cytogenetic band:  3p25.1   HGNC cytogenetic band: 3p24.3

SH3BP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SH3BP5 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M015296:  view genomic region     (about GC identifiers)

Start:
15,296,357 bp from pter      End:
15,382,901 bp from pter
Size:
86,545 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: 3BP5_HUMAN, O60239 (See protein sequence)
Recommended Name: SH3 domain-binding protein 5  
Size: 455 amino acids; 50425 Da
Subunit: Interacts with BTK. Interacts with all isoforms of MAPK8, MAPK9, MAPK10 and MAPK12
Subcellular location: Mitochondrion
Sequence caution: Sequence=BAA25922.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for SH3BP5:
4H3B (3D)    
Secondary accessions: B3KQW6 Q5JWV9
Alternative splicing: 2 isoforms:  O60239-1   O60239-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SH3BP5: NX_O60239

Explore proteomics data for SH3BP5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60239

  • SH3BP5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SH3BP5 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001018009.2  NP_004835.2  

    ENSEMBL proteins: 
     ENSP00000373301   ENSP00000400128   ENSP00000388553   ENSP00000386231   ENSP00000394115  
     ENSP00000389484   ENSP00000408246   ENSP00000253688  

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SH3BP5 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS9571151
    GO:0005739mitochondrion IEA--

    SH3BP5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007940 SH3-bd_5

    Graphical View of Domain Structure for InterPro Entry O60239

    ProtoNet protein and cluster: O60239

    1 Blocks protein domain: IPB007940 SH3-binding 5

    UniProtKB/Swiss-Prot: 3BP5_HUMAN, O60239
    Similarity: Belongs to the SH3BP5 family


    SH3BP5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 3BP5_HUMAN, O60239
    Function: Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in
    BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death

         Genatlas biochemistry entry for SH3BP5:
    SH3-domain binding protein 5,BTK-associated transregulator

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004860protein kinase inhibitor activity IDA10339589
    GO:0005515protein binding IPI9571151
    GO:0017124SH3 domain binding IEA--
         
    SH3BP5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SH3BP5:
     Increased HPV18 LCR reporter a 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidSH3BP5 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SH3BP5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1B cell receptor signaling pathway
    BCR signaling pathway0.42


    1 BioSystems Pathway for SH3BP5
        BCR signaling pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SH3BP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/25 Interacting proteins for SH3BP5 (O602391, 3 ENSP000003733014) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTKQ061871, 3, ENSP000003081764EBI-624860,EBI-624835 I2D: score=4 STRING: ENSP00000308176
    MAPK8P459833, ENSP000003534834I2D: score=7 STRING: ENSP00000353483
    MAPK9P459843, ENSP000003214104I2D: score=7 STRING: ENSP00000321410
    MAPK10P537793, ENSP000003521574I2D: score=5 STRING: ENSP00000352157
    DISC1Q9NRI53, ENSP000003555964I2D: score=2 STRING: ENSP00000355596
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006469negative regulation of protein kinase activity ----
    GO:0007165signal transduction TAS9571151
    GO:0035556intracellular signal transduction IDA10339589

    SH3BP5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SH3BP5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SH3BP5 (3BP5)

    2 Novoseek inferred chemical compound relationships for SH3BP5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 49.8 11 9571151 (3), 10339589 (3), 8910422 (1), 9593709 (1) (see all 5)
    proline 38.4 2 7865733 (1)

    Search CenterWatch for drugs/clinical trials and news about SH3BP5 / 3BP5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SH3BP5 gene (2 alternative transcripts): 
    NM_001018009.3  NM_004844.4  

    Unigene Cluster for SH3BP5:

    SH3-domain binding protein 5 (BTK-associated)
    Hs.257761  [show with all ESTs]
    Unigene Representative Sequence: NM_004844
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000383791(uc003bzp.1 uc003bzq.1 uc003bzr.1) ENST00000412806
    ENST00000426925 ENST00000408919 ENST00000366391 ENST00000450625 ENST00000417936
    ENST00000465894 ENST00000459627 ENST00000253688
    miRNA
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    hsa-miR-137 hsa-miR-24-1* hsa-miR-106a hsa-miR-1260b hsa-miR-1271 hsa-miR-519a hsa-miR-103a hsa-miR-24-2*
    SwitchGear 3'UTR luciferase reporter plasmidSH3BP5 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB005047.1 AK090524.1 AK313167.1 AL117422.1 BC006169.1 BC010123.2 BC023195.1 

    18 DOTS entries:

    DT.447084  DT.100748950  DT.100832414  DT.95341487  DT.210312  DT.91763186  DT.95341505  DT.100012342 
    DT.91763188  DT.100029189  DT.120862216  DT.100745137  DT.100748948  DT.101962609  DT.120862248  DT.40121424 
    DT.91763192  DT.95341469 

    24/350 AceView cDNA sequences (see all 350):

    CD742758 CR592833 AI654164 CR601004 AA450004 BU734937 BM012094 AA412100 
    AI144169 AW089359 BE409044 T34118 BU616472 AI890677 CN480786 AV746045 
    BX641159 BM905020 BC010123 AA065095 BU180669 AI933009 BE900831 AI244192 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SH3BP5 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c
    SP1:        -     -           -           -     -     -     -                                                     -     -                           
    SP2:                          -           -     -     -     -     -     -                                         -     -                           
    SP3:                                      -     -     -     -     -     -                                         -     -                           
    SP4:                                      -     -     -     -     -     -                                                                           
    SP5:                                                              -     -                                                                           


    ECgene alternative splicing isoforms for SH3BP5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SH3BP5 expression in normal human tissues (normalized intensities)      SH3BP5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAATGCATA
    SH3BP5 Expression
    About this image


    SH3BP5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Adrenal Gland (Endocrine System)
             Adrenal Cortex   
     
     Blood (Hematopoietic System)
             b cells   
     
     Dermis (Integumentary System)
             Guard Dermal Papilla Cells Dermal Papilla
     
     Testis (Reproductive System)

    See SH3BP5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SH3BP5

    SOURCE GeneReport for Unigene cluster: Hs.257761

    UniProtKB/Swiss-Prot: 3BP5_HUMAN, O60239
    Tissue specificity: Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including
    spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SH3BP5 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sh3bp51 , 5 SH3-domain binding protein 5 (BTK-associated)1, 5 88.57(n)1
    92.75(a)1
      14 (19.11 cM)5
    240561  NM_011894.21  NP_036024.21 
     313598805 
    chicken
    (Gallus gallus)
    Aves SH3BP51 SH3-domain binding protein 5 (BTK-associated) 78.49(n)
    87.93(a)
      420682  NM_001030989.1  NP_001026160.1 
    lizard
    (Anolis carolinensis)
    Reptilia SH3BP56
    SH3-domain binding protein 5 (BTK-associated)
    83(a)
    1 ↔ 1
    6(36486603-36566621)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC757312 hypothetical protein MGC75731 75.56(n)    BC063334.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.74172 Danio rerio mRNA similar to SH3-domain binding protein more 78.12(n)    BC044426.1 
    worm
    (Caenorhabditis elegans)
    Secernentea K03E6.76
    C03C10.46
    Uncharacterized protein C03C10.4
    25(a)
    20(a)
    possible ortholog
    possible ortholog
    X(1084222-1088150)
    III(4096901-4098133)


    ENSEMBL Gene Tree for SH3BP5 (if available)
    TreeFam Gene Tree for SH3BP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SH3BP5 gene
    SH3BP5L2  
    2 SIMAP similar genes for SH3BP5 using alignment to 5 protein entries:     3BP5_HUMAN (see all proteins):
    DKFZp686F05233    SH3BP5L

    SH3BP5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1879 SNPs in SH3BP5 are shown (see all 1879)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs93104721,2
    C,F,H--15306599(+) AGCTCC/TGAGCC 2 -- int134Minor allele frequency- T:0.09NS EA NA WA 3386
    rs1395149171,2
    C--15306682(+) CACGTC/GTACCA 2 -- int10--------
    rs1828315811,2
    --15306736(+) TCCAGG/TGCAGC 2 -- int10--------
    rs1497041411,2
    C--15306852(+) ACCACA/GTCTCT 2 -- int10--------
    rs795393411,2
    C,F--15306946(+) TGAACC/TTGGGA 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs1872511241,2
    --15306979(+) GATCGC/TGCCGC 2 -- int10--------
    rs1921800861,2
    --15306991(+) GCACTC/GCAGCC 2 -- int10--------
    rs1823679681,2
    C--15307021(+) CCGTCA/TCACAC 2 -- int10--------
    rs1880104591,2
    --15307224(+) ATGTGC/GGTCAG 2 -- int10--------
    rs1926768011,2
    --15307304(+) AGCAGC/GATACT 2 -- int10--------

    HapMap Linkage Disequilibrium report for SH3BP5 (15296357 - 15382901 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for SH3BP5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2724962CNV Deletion23290073
    esv2113465CNV Deletion18987734
    esv3951CNV Deletion18987735
    esv2724963CNV Deletion23290073
    dgv852e199CNV Deletion23128226
    nsv522980CNV Loss19592680
    nsv524536CNV Loss19592680
    nsv876581CNV Gain21882294
    nsv428413CNV Gain18775914
    nsv834621CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605612    OMIM disorders: --

    10 diseases for SH3BP5:    About MalaCards
    tabes dorsalis    bursitis    agammaglobulinemia    bacteriuria
    osteomyelitis    endocarditis    alcohol dependence    schizophrenia
    alcoholism    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for SH3BP5:
    Endocarditis     Bursitis

    SH3BP5 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for SH3BP5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    x-linked agammaglobulinemia 81.8 1 9571151 (1)
    immunodeficiency 12.4 1 9571151 (1)

    Genetic Association Database (GAD): SH3BP5

    Export disorders for SH3BP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SH3BP5 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with SH3BP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein. (PubMed id 10339589)1, 2, 3, 9 Yamadori T....Tsukada S. (1999)
    2. Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (Btk). (PubMed id 9571151)1, 2, 3, 9 Matsushita M.... Tsukada S. (1998)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria. (PubMed id 12167088)1, 2 Wiltshire C.... May G.H. (2002)
    7. Sab (SH3BP5), a novel mitochondria-localized JNK-interacting protein. (PubMed id 15506969)1, 9 Wiltshire C....May G.H. (2004)
    8. Genome-wide association study of alcohol dependence im plicates KIAA0040 on chromosome 1q. (PubMed id 21956439)1 Zuo L....Luo X. (2012)
    9. Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence. (PubMed id 22488850)1 Zuo L....Luo X. (2012)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9467 HGNC: 10827 AceView: SH3BP5 Ensembl:ENSG00000131370 euGenes: HUgn9467
    ECgene: SH3BP5 H-InvDB: SH3BP5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SH3BP5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SH3BP5 gene:
    Search GeneIP for patents involving SH3BP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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