Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SH3BP5 Gene

Aliases for SH3BP5 Gene

  • SH3 Domain Binding Protein 5 2 3
  • SH3-Domain Binding Protein 5 (BTK-Associated) 2 3 5
  • SH3 Domain-Binding Protein That Preferentially Associates With BTK 3 4
  • SH3BP-5 3 4
  • SAB 3 4
  • SH3 Binding Protein 2

External Ids for SH3BP5 Gene

Previous GeneCards Identifiers for SH3BP5 Gene

  • GC03M015225
  • GC03M015271
  • GC03M015296

Summaries for SH3BP5 Gene

GeneCards Summary for SH3BP5 Gene

SH3BP5 (SH3 Domain Binding Protein 5) is a Protein Coding gene. Diseases associated with SH3BP5 include Endocardium Disease and Tabes Dorsalis. Among its related pathways are B cell receptor signaling pathway (KEGG). GO annotations related to this gene include SH3 domain binding and protein kinase inhibitor activity. An important paralog of this gene is SH3BP5L.

UniProtKB/Swiss-Prot for SH3BP5 Gene

  • Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.

Gene Wiki entry for SH3BP5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3BP5 Gene

Genomics for SH3BP5 Gene

Regulatory Elements for SH3BP5 Gene

Enhancers for SH3BP5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SH3BP5 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SH3BP5 gene promoter:

Genomic Location for SH3BP5 Gene

15,254,353 bp from pter
15,341,394 bp from pter
87,042 bases
Minus strand

Genomic View for SH3BP5 Gene

Genes around SH3BP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3BP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3BP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3BP5 Gene

Proteins for SH3BP5 Gene

  • Protein details for SH3BP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH3 domain-binding protein 5
    Protein Accession:
    Secondary Accessions:
    • B3KQW6
    • Q5JWV9

    Protein attributes for SH3BP5 Gene

    455 amino acids
    Molecular mass:
    50425 Da
    Quaternary structure:
    • Interacts with BTK (PubMed:9571151, PubMed:10339589). Interacts with all isoforms of MAPK8, MAPK9, MAPK10 and MAPK12 (PubMed:12167088). Interacts with GDP-bound and nucleotide-free forms of RAB11A (PubMed:26506309).
    • Sequence=BAA25922.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SH3BP5 Gene

    Alternative splice isoforms for SH3BP5 Gene


neXtProt entry for SH3BP5 Gene

Proteomics data for SH3BP5 Gene at MOPED

Post-translational modifications for SH3BP5 Gene

  • Ubiquitination at Lys 173, Lys 215, and Lys 248
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SH3BP5 Gene

Domains & Families for SH3BP5 Gene

Protein Domains for SH3BP5 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SH3BP5 family.
  • Belongs to the SH3BP5 family.
genes like me logo Genes that share domains with SH3BP5: view

No data available for Gene Families for SH3BP5 Gene

Function for SH3BP5 Gene

Molecular function for SH3BP5 Gene

GENATLAS Biochemistry:
SH3-domain binding protein 5,BTK-associated transregulator
UniProtKB/Swiss-Prot Function:
Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.

Gene Ontology (GO) - Molecular Function for SH3BP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IDA 10339589
genes like me logo Genes that share ontologies with SH3BP5: view
genes like me logo Genes that share phenotypes with SH3BP5: view

Animal Models for SH3BP5 Gene

MGI Knock Outs for SH3BP5:

Animal Model Products

CRISPR Products

miRNA for SH3BP5 Gene

miRTarBase miRNAs that target SH3BP5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SH3BP5 Gene

Localization for SH3BP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH3BP5 Gene


Subcellular locations from

Jensen Localization Image for SH3BP5 Gene COMPARTMENTS Subcellular localization image for SH3BP5 gene
Compartment Confidence
mitochondrion 4
nucleus 3
cytosol 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for SH3BP5 Gene

Pathways & Interactions for SH3BP5 Gene

SuperPathways for SH3BP5 Gene

genes like me logo Genes that share pathways with SH3BP5: view

Pathways by source for SH3BP5 Gene

1 BioSystems pathway for SH3BP5 Gene

Gene Ontology (GO) - Biological Process for SH3BP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9571151
GO:0061099 negative regulation of protein tyrosine kinase activity IBA --
GO:1904030 negative regulation of cyclin-dependent protein kinase activity IDA --
genes like me logo Genes that share ontologies with SH3BP5: view

No data available for SIGNOR curated interactions for SH3BP5 Gene

Drugs & Compounds for SH3BP5 Gene

(5) Drugs for SH3BP5 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AVL-292 Pharma Btk inhibitor 0
CGI-1746 Pharma Btk inhibitor 0
RN486 Pharma Btk inhibitor,potent and selective 0

(3) ApexBio Compounds for SH3BP5 Gene

Compound Action Cas Number
AVL-292 Btk inhibitor 1202757-89-8
CGI-1746 Btk inhibitor 910232-84-7
RN486 Btk inhibitor,potent and selective 1242156-23-5
genes like me logo Genes that share compounds with SH3BP5: view

Transcripts for SH3BP5 Gene

Unigene Clusters for SH3BP5 Gene

SH3-domain binding protein 5 (BTK-associated):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SH3BP5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - -
SP6: - - - - - -
SP7: -
SP8: - - -

Relevant External Links for SH3BP5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH3BP5 Gene

mRNA expression in normal human tissues for SH3BP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SH3BP5 Gene

This gene is overexpressed in Serum (24.7), Liver, secretome (11.0), Liver (9.6), and Lung (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SH3BP5 Gene

SOURCE GeneReport for Unigene cluster for SH3BP5 Gene Hs.257761

mRNA Expression by UniProt/SwissProt for SH3BP5 Gene

Tissue specificity: Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate.
genes like me logo Genes that share expression patterns with SH3BP5: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for SH3BP5 Gene

Orthologs for SH3BP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3BP5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SH3BP5 35
  • 82.7 (n)
  • 84.41 (a)
SH3BP5 36
  • 84 (a)
(Canis familiaris)
Mammalia SH3BP5 35
  • 92.97 (n)
  • 98.04 (a)
SH3BP5 36
  • 97 (a)
(Mus musculus)
Mammalia Sh3bp5 35
  • 87.99 (n)
  • 91.43 (a)
Sh3bp5 16
Sh3bp5 36
  • 91 (a)
(Pan troglodytes)
Mammalia SH3BP5 35
  • 99.56 (n)
  • 100 (a)
SH3BP5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Sh3bp5 35
  • 88.35 (n)
  • 91.65 (a)
(Monodelphis domestica)
Mammalia SH3BP5 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia SH3BP5 36
  • 89 (a)
(Gallus gallus)
Aves SH3BP5 35
  • 78.16 (n)
  • 86.6 (a)
SH3BP5 36
  • 85 (a)
(Anolis carolinensis)
Reptilia SH3BP5 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75731 35
sh3bp5 35
  • 73.89 (n)
  • 80.1 (a)
(Danio rerio)
Actinopterygii Dr.7417 35
sh3bp5b 35
  • 73.87 (n)
  • 79.22 (a)
sh3bp5b 36
  • 67 (a)
fruit fly
(Drosophila melanogaster)
Insecta pcs 37
  • 48 (a)
CG14408 36
  • 16 (a)
Species with no ortholog for SH3BP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SH3BP5 Gene

Gene Tree for SH3BP5 (if available)
Gene Tree for SH3BP5 (if available)

Paralogs for SH3BP5 Gene

Paralogs for SH3BP5 Gene

(2) SIMAP similar genes for SH3BP5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SH3BP5: view

Variants for SH3BP5 Gene

Sequence variations from dbSNP and Humsavar for SH3BP5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs712868 -- 15,266,125(+) TCAGG(A/G)GCCTC intron-variant
rs712869 -- 15,296,193(-) TCTTC(A/T)TGAAG intron-variant
rs1106130 -- 15,290,803(-) CTCAT(A/G)GAGGA intron-variant
rs2279739 -- 15,269,402(-) CCAGG(C/G)TTTGC intron-variant
rs826422 -- 15,299,558(+) GAGAC(A/T)TCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH3BP5 Gene

Variant ID Type Subtype PubMed ID
nsv428413 CNV Gain 18775914
esv2724962 CNV Deletion 23290073
esv2113465 CNV Deletion 18987734
esv3951 CNV Deletion 18987735
esv2724963 CNV Deletion 23290073
dgv852e199 CNV Deletion 23128226
nsv876581 CNV Gain 21882294
nsv524536 CNV Loss 19592680
nsv834621 CNV Gain 17160897
nsv522980 CNV Loss 19592680

Variation tolerance for SH3BP5 Gene

Residual Variation Intolerance Score: 15.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.20% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SH3BP5 Gene

Disorders for SH3BP5 Gene

MalaCards: The human disease database

(6) MalaCards diseases for SH3BP5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
endocardium disease
tabes dorsalis
  • posterior spinal sclerosis
paralytic squint
  • incomitant dissociation
  • causalgia nos
tertiary neurosyphilis
  • late neurosyphilis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SH3BP5

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SH3BP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SH3BP5 Gene

Publications for SH3BP5 Gene

  1. Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein. (PMID: 10339589) Yamadori T. … Tsukada S. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 23 67
  2. Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (Btk). (PMID: 9571151) Matsushita M. … Tsukada S. (Biochem. Biophys. Res. Commun. 1998) 2 3 23
  3. Sab (SH3BP5), a novel mitochondria-localized JNK-interacting protein. (PMID: 15506969) Wiltshire C. … May G.H. (Biochem. Soc. Trans. 2004) 3 23
  4. Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity. (PMID: 25666017) Win S. … Kaplowitz N. (J. Hepatol. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for SH3BP5 Gene

Sources for SH3BP5 Gene