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SH3BP4 Gene

protein-coding   GIFtS: 57
GCID: GC02P235876

SH3-Domain Binding Protein 4

  Search for SH3BP4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SH3-Domain Binding Protein 41 2     EH-Binding Protein 102 3
BOG252 3 5     SH3 Domain-Binding Protein 42
Transferrin Receptor-Trafficking Protein2 3     EHB103
TTP2 3     

External Ids:    HGNC: 108261   Entrez Gene: 236772   Ensembl: ENSG000001301477   OMIM: 6056115   UniProtKB: Q9P0V33   

Export aliases for SH3BP4 gene to outside databases

Previous GC identifers: GC02P233898 GC02P234542 GC02P236147 GC02P235642 GC02P235525 GC02P227701


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SH3BP4 Gene:
This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear
targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of
clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor.
(provided by RefSeq, Jul 2008)

GeneCards Summary for SH3BP4 Gene:
SH3BP4 (SH3-domain binding protein 4) is a protein-coding gene. GO annotations related to this gene include GDP-dissociation inhibitor activity and identical protein binding. An important paralog of this gene is MACC1.

UniProtKB/Swiss-Prot: SH3B4_HUMAN, Q9P0V3
Function: May function in transferrin receptor internalization at the plasma membrane through a cargo-specific
control of clathrin-mediated endocytosis. Alternatively, may acts as a negative regulator of the amino
acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds
inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its
relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and
autophagy

Gene Wiki entry for SH3BP4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the SH3BP4 gene promoter:
         FOXO3   AP-2gamma   FOXO3b   C/EBPalpha   AREB6   FOXO3a   AP-2beta   ZIC2/Zic2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SH3BP4 promoter sequence
   Search Chromatin IP Primers for SH3BP4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SH3BP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1-q37.2   Ensembl cytogenetic band:  2q37.2   HGNC cytogenetic band: 2q37.1-q37.2

SH3BP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SH3BP4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P235876:  view genomic region     (about GC identifiers)

Start:
235,860,617 bp from pter      End:
235,964,358 bp from pter
Size:
103,742 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SH3B4_HUMAN, Q9P0V3 (See protein sequence)
Recommended Name: SH3 domain-binding protein 4  
Size: 963 amino acids; 107496 Da
Subunit: Homodimer or homooligomer. Interacts with DNM2, EPS15, clathrin, the adapter protein complex 2/AP-2 and
TFRC. Interacts with the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; the interaction is most probably direct,
preferentially occurs with their inactive GDP-bound form and is negatively regulated by amino acids
Miscellaneous: Overexpression or depletion of SH3BP4 result in a specific decrease of the transferrin receptor
endocytosis that can be rescued by DNM2 overexpression
Secondary accessions: O95082 Q309A3 Q53QD0 Q53TD1
Alternative splicing: 2 isoforms:  Q9P0V3-1   Q9P0V3-2   (No experimental confirmation available. Dubious isoform produced through aberrant splice sites)

Explore the universe of human proteins at neXtProt for SH3BP4: NX_Q9P0V3

Explore proteomics data for SH3BP4 at MOPED

Post-translational modifications: 

  • Phosphorylated upon EGF stimulation. Phosphorylation prevents interaction with DNM21
  • Ubiquitination2 at Lys657
  • Modification sites at PhosphoSitePlus

  • See SH3BP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055336.1  
    ENSEMBL proteins: 
     ENSP00000375867   ENSP00000403251   ENSP00000386862   ENSP00000340237   ENSP00000387995  
     ENSP00000415391   ENSP00000414740  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001452 SH3_domain
     IPR000906 ZU5
     IPR011511 SH3_2

    Graphical View of Domain Structure for InterPro Entry Q9P0V3

    ProtoNet protein and cluster: Q9P0V3

    1 Blocks protein domain: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: SH3B4_HUMAN, Q9P0V3
    Domain: The SH3 domain mediates localization to the clathrin-coated pits and vesicles. The SH3 domain mediates
    interaction with DNM2 and the cytoplasmic part of TFRC with a lower affinity. The SH3 domain also mediates
    interaction with RRAGB, RRAGC and is required for the negative regulation of mTORC1
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with SH3BP4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SH3B4_HUMAN, Q9P0V3
    Function: May function in transferrin receptor internalization at the plasma membrane through a cargo-specific
    control of clathrin-mediated endocytosis. Alternatively, may acts as a negative regulator of the amino
    acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds
    inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its
    relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and
    autophagy

         Genatlas biochemistry entry for SH3BP4:
    SMC homology domain 3 (SH3) binding protein 4,expressed by corneal fibroblast and other tissues with higher levels
    in pancreas,placenta,heart,kidney,localized in the nucleus,may be involved in a newly cascade of proteins
    involved in endocytosis,intracellular sorting and the cell cycle

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005092GDP-dissociation inhibitor activity IMP--
    GO:0005515protein binding IPI16325581
    GO:0017016Ras GTPase binding IPI--
    GO:0042802identical protein binding IPI16325581
         
    Find genes that share ontologies with SH3BP4           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SH3BP4:
     Decreased POU5F1-GFP protein e  Increased cell death in breast 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SH3B4_HUMAN, Q9P0V3: Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus
    (Probable). Note=Specifically associated with transferrin receptor-containing clathrin-coated pits and
    clathrin-coated vesicles. May also localize to the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005905coated pit IEA--
    GO:0030136clathrin-coated vesicle IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with SH3BP4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SH3BP4
    Interactions:

        GeneGlobe Interaction Network for SH3BP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SH3BP4 (Q9P0V31, 2, 3 ENSP000003402374) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DNM2P505701, 2, 3, ENSP000003527214EBI-1049513,EBI-346547 MINT-7160580 MINT-7160249 MINT-7160329 I2D: score=1 STRING: ENSP00000352721
    SH3BP4Q9P0V31, 2EBI-1049513,EBI-1049513 MINT-7184302 MINT-7159901
    SFNP319472, 3MINT-3975625 I2D: score=3 
    TFRCP027861, 2, 3, ENSP000003532244EBI-1049513,EBI-355727 MINT-7160681 MINT-7183598 MINT-7159892 MINT-7183510 MINT-7159844 MINT-7160658 I2D: score=1 STRING: ENSP00000353224
    YWHAGP619812, 3, ENSP000003063304MINT-50386 MINT-50829 I2D: score=6 STRING: ENSP00000306330
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0008285negative regulation of cell proliferation IMP--
    GO:0010508positive regulation of autophagy IMP--
    GO:0030308negative regulation of cell growth IMP--
    GO:0032007negative regulation of TOR signaling IMP--

    Find genes that share ontologies with SH3BP4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for SH3BP4 (SH3B4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SH3BP4 gene: 
    NM_014521.2  

    Unigene Cluster for SH3BP4:

    SH3-domain binding protein 4
    Hs.516777  [show with all ESTs]
    Unigene Representative Sequence: BC057396
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392011(uc002vvp.3) ENST00000484097 ENST00000416021 ENST00000409212(uc010fym.3)
    ENST00000489601 ENST00000344528(uc002vvq.3) ENST00000444916 ENST00000446904
    ENST00000462602 ENST00000493436 ENST00000454947
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    hsa-miR-582-3p hsa-miR-330-5p hsa-miR-218 hsa-miR-29b-1* hsa-miR-9 hsa-miR-326 hsa-miR-3148 hsa-miR-509-3-5p
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    Additional mRNA sequence: 

    AF015043.1 AF147747.1 AK291209.1 AK304398.1 BC057396.1 BX647198.1 BX648877.1 DQ232895.1 

    9 DOTS entries:

    DT.99996558  DT.416277  DT.100649389  DT.452360  DT.100782163  DT.121012228  DT.121012239  DT.92036750 
    DT.95278202 

    Selected AceView cDNA sequences (see all 222):

    AF147747 AA863334 BQ939766 AI694805 CB151032 AA336974 CK430139 AA337291 
    CD107677 BE504187 CA448380 BC057396 AW612665 W72796 T30337 BG740895 
    BI963085 BM997596 AF015043 CB129132 AA309491 CK903651 BM666283 BQ233667 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SH3BP4 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
    SP1:                                -     -     -                                                     -                           
    SP2:                          -     -     -     -           -                                         -                           
    SP3:        -     -     -     -     -     -     -                                                     -                           
    SP4:                          -     -     -     -                                                                                 
    SP5:                                            -                                                                                 


    ECgene alternative splicing isoforms for SH3BP4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SH3BP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SH3BP4 Expression
    About this image


    SH3BP4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
    SH3BP4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SH3BP4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516777

    UniProtKB/Swiss-Prot: SH3B4_HUMAN, Q9P0V3
    Tissue specificity: Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal
    pigment epithelial cells (at protein level)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SH3BP4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sh3bp41 , 5 SH3-domain binding protein 41, 5 85.92(n)1
    91.88(a)1
      1 (45.05 cM)5
    984021  NM_133816.21  NP_598577.11 
     890704155 
    chicken
    (Gallus gallus)
    Aves SH3BP41 SH3-domain binding protein 4 77.71(n)
    83.8(a)
      424027  XM_004942500.1  XP_004942557.1 
    lizard
    (Anolis carolinensis)
    Reptilia SH3BP46
    SH3-domain binding protein 4
    80(a)
    1 ↔ 1
    1(118936013-119001224)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.4582 Transcribed sequence with moderate similarity to protein more 73.45(n)    BX721655.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.170772 Danio rerio SH3BP4 mRNA for src homology 3 binding more 76.14(n)    AB114633.1 


    ENSEMBL Gene Tree for SH3BP4 (if available)
    TreeFam Gene Tree for SH3BP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SH3BP4 gene
    MACC12  
    2 SIMAP similar genes for SH3BP4 using alignment to 5 protein entries:     SH3B4_HUMAN (see all proteins):
    MACC1    NCK2

    Find genes that share paralogs with SH3BP4           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for SH3BP4
    PGOHUM00000239879 PGOHUM00000243237


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SH3BP4 (see all 2587)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1817615691,2
    --235858645(+) ATTCTC/GCGTTT 1 -- us2k10--------
    rs1166464591,2
    F--235858654(+) TTCCAT/CGGCAC 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1854620281,2
    --235858670(+) TCTTTC/GTGGTT 1 -- us2k10--------
    rs755454591,2
    F--235858696(+) TCCCTC/TTCTGC 1 -- us2k11Minor allele frequency- T:0.09WA 118
    rs1418859501,2
    C--235858729(+) CAGGCC/TTTGAG 1 -- us2k10--------
    rs1471193951,2
    --235858746(+) TATTCA/GATTGT 1 -- us2k10--------
    rs745930411,2
    C,F--235858758(+) TTTTGT/CGTGTG 1 -- us2k11Minor allele frequency- C:0.07EA 120
    rs753153271,2
    C,F--235858798(+) TAGTCA/GAGGAG 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1899850431,2
    --235858801(+) TCAAGA/GAGCTT 1 -- us2k10--------
    rs1477352761,2
    --235858835(+) CATTTA/CAGGAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SH3BP4 (235860617 - 235964358 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SH3BP4 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721679CNV Deletion23290073
    esv2721681CNV Deletion23290073
    esv2721682CNV Deletion23290073
    esv2721678CNV Deletion23290073
    esv1367526CNV Deletion17803354
    esv993755CNV Deletion20482838
    esv2721684CNV Deletion23290073
    esv3796CNV Deletion18987735
    esv2721680CNV Deletion23290073
    nsv3220CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SH3BP4
    DNA2.0 Custom Variant and Variant Library Synthesis for SH3BP4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605611    OMIM disorders: --


    Find genes that share disorders with SH3BP4           About GenesLikeMe

    Genetic Association Database (GAD): SH3BP4
    Human Genome Epidemiology (HuGE) Navigator: SH3BP4 (1 document)

    Export disorders for SH3BP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SH3BP4 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with SH3BP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, chromosomal localization, and characterization of cDNA from a novel gene, SH3BP4, expressed by human corneal fibroblasts. (PubMed id 10644451)1, 2, 3, 9 Dunlevy J.R....Hassell J.R. (Genomics 1999)
    2. SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling. (PubMed id 22575674)1, 2 Kim Y.M....Kim D.H. (Mol. Cell 2012)
    3. Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts. (PubMed id 22419666)1, 4 Shi M....Beaty T.H. (Am. J. Med. Genet. A 2012)
    4. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PubMed id 21546767)1, 4 Murea M....Freedman B.I. (Am. J. Nephrol. 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    7. TTP specifically regulates the internalization of the transferrin receptor. (PubMed id 16325581)1, 2 Tosoni D.... Di Fiore P.P. (Cell 2005)
    8. Nuclear and plasma membrane localization of SH3BP4 in retinal pigment epithelial cells. (PubMed id 15616480)1, 2 Khanobdee K.... Dunlevy J.R. (Mol. Vis. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. (PubMed id 9303539)1, 2 Salcini A.E.... Di Fiore P.P. (Genes Dev. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23677 HGNC: 10826 AceView: SH3BP4 Ensembl:ENSG00000130147 euGenes: HUgn23677
    ECgene: SH3BP4 H-InvDB: SH3BP4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SH3BP4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SH3BP4 gene:
    Search GeneIP for patents involving SH3BP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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