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SH3BP2 Gene

protein-coding   GIFtS: 59
GCID: GC04P002794

SH3-Domain Binding Protein 2

(Previous name: Cherubism)
  See SH3BP2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SH3-Domain Binding Protein 21 2     CRBM2
3BP-22 3     Abl-SH3 Binding Protein 22
3BP22 3     SH3 Domain-Binding Protein 22
CRPM2 5     TNFAIP3 Interacting Protein 22
Cherubism1     

External Ids:    HGNC: 108251   Entrez Gene: 64522   Ensembl: ENSG000000872667   OMIM: 6021045   UniProtKB: P783143   

Export aliases for SH3BP2 gene to outside databases

Previous GC identifers: GC04P002783 GC04M9I0057 GC04P002826 GC04P002851 GC04P002831


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SH3BP2 Gene:
The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich
region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1
and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate
transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in
cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Mar 2009)

GeneCards Summary for SH3BP2 Gene:
SH3BP2 (SH3-domain binding protein 2) is a protein-coding gene. Diseases associated with SH3BP2 include cherubism, and giant cell reparative granuloma. GO annotations related to this gene include SH3/SH2 adaptor activity and phospholipid binding.

UniProtKB/Swiss-Prot: 3BP2_HUMAN, P78314
Function: Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to
phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a
phosphorylation dependent mechanism




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006051.19  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SH3BP2 gene promoter:
         NCX/Ncx   RelA   AP-2gamma   NF-kappaB   HEN1   STAT3   ARP-1   Cart-1   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SH3BP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SH3BP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

SH3BP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SH3BP2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P002794:  view genomic region     (about GC identifiers)

Start:
2,794,750 bp from pter      End:
2,842,825 bp from pter
Size:
48,076 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: 3BP2_HUMAN, P78314 (See protein sequence)
Recommended Name: SH3 domain-binding protein 2  
Size: 561 amino acids; 62244 Da
2 PDB 3D structures from and Proteopedia for SH3BP2:
2CR4 (3D)        3TWR (3D)    
Secondary accessions: A6NNC2 B2R5R6 B4DT04 D3DVR0 O00500 O15373 P78315
Alternative splicing: 3 isoforms:  P78314-1   P78314-2   P78314-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SH3BP2: NX_P78314

Explore proteomics data for SH3BP2 at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation at Tyr-448 may stimulate the activity of the LYN kinase (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SH3BP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001116153.1  NP_001139327.1  NP_001139328.1  NP_003014.3  

    ENSEMBL proteins: 
     ENSP00000409746   ENSP00000422796   ENSP00000423275   ENSP00000424917   ENSP00000424072  
     ENSP00000424105   ENSP00000423823   ENSP00000425537   ENSP00000403231   ENSP00000424846  
     ENSP00000422605   ENSP00000348685   ENSP00000426818   ENSP00000388152   ENSP00000422168  
     ENSP00000374488  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    SH2D: SH2 domain containing

    3 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry P78314

    ProtoNet protein and cluster: P78314

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: 3BP2_HUMAN, P78314
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 SH2 domain


    Find genes that share domains with SH3BP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 3BP2_HUMAN, P78314
    Function: Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to
    phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a
    phosphorylation dependent mechanism

         Genatlas biochemistry entry for SH3BP2:
    Src homology domain 3 (SH3) binding protein BP2,mouse homolog within a common region of deletion in bladder
    carcinoma

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity TAS9299232
    GO:0005515protein binding IPI11390470
    GO:0017124SH3 domain binding IEA--
         
    Find genes that share ontologies with SH3BP2           About GenesLikeMe


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Sh3bp2):
     cellular  craniofacial  digestive/alimentary  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  mortality/aging  muscle 
     nervous system  respiratory system  skeleton  vision/eye 

    Find genes that share phenotypes with SH3BP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SH3BP2: Sh3bp2tm1Rtpl Sh3bp2tm1Geha

       genOway: Develop your customized and physiologically relevant rodent model for SH3BP2

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    miRTarBase miRNAs that target SH3BP2:
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    7 qRT-PCR Assays for microRNAs that regulate SH3BP2:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    cytoskeleton1
    extracellular1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SH3BP2 About    
    See pathways by source

    SuperPathContained pathways About
    1TCR signaling in naive CD4+ T cells
    TCR signaling in naive CD4+ T cells0.64
    2Immune response Role of DAP12 receptors in NK cells
    Natural killer cell mediated cytotoxicity0.31
    3B Cell Receptor Signaling Pathway (WikiPathways)
    B Cell Receptor Signaling Pathway


    Find genes that share SuperPaths with SH3BP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for SH3BP2
        B Cell Receptor Signaling Pathway
    TCR signaling in naive CD4+ T cells


    1 Kegg Pathway  (Kegg details for SH3BP2):
        Natural killer cell mediated cytotoxicity

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SH3BP2
    Interactions:

        GeneGlobe Interaction Network for SH3BP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SH3BP2 (P783141, 2, 3 ENSP000003486854) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VAV1P154981, 2, 3, ENSP000003022694EBI-727062,EBI-625518 MINT-4563411 MINT-4549720 MINT-7301369 MINT-7301313 MINT-7301258 MINT-7301359 MINT-8026718 MINT-7301343 I2D: score=3 STRING: ENSP00000302269
    SH3KBP1Q96B971, 2, 3, ENSP000003809214EBI-727062,EBI-346595 MINT-4550212 MINT-4563210 MINT-4551264 MINT-4563320 MINT-4563239 MINT-4549116 MINT-4551452 MINT-4563367 I2D: score=2 STRING: ENSP00000380921
    YWHAQP273482, 3, ENSP000002380814MINT-18071 MINT-17096 MINT-18073 MINT-17097 MINT-17095 MINT-8006273 MINT-18070 MINT-8006280 I2D: score=2 STRING: ENSP00000238081
    DBNLQ9UJU61, 2, 3EBI-727062,EBI-751783 MINT-4563296 MINT-4563345 MINT-4563411 MINT-4549882 MINT-4563261 MINT-4563277 MINT-4563396 I2D: score=2 
    VAV2P527351, 2, 3, ENSP000003609164EBI-727062,EBI-297549 MINT-7301295 MINT-7301276 MINT-7301412 MINT-8026751 I2D: score=2 STRING: ENSP00000360916
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS9299232
    GO:0009967positive regulation of signal transduction TAS9299232

    Find genes that share ontologies with SH3BP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SH3BP2 (3BP2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SH3BP2 gene (4 alternative transcripts): 
    NM_001122681.1  NM_001145855.1  NM_001145856.1  NM_003023.4  

    Unigene Cluster for SH3BP2:

    SH3-domain binding protein 2
    Hs.167679  [show with all ESTs]
    Unigene Representative Sequence: NM_001145855
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000452765 ENST00000503219 ENST00000512131 ENST00000510193 ENST00000511237
    ENST00000510074 ENST00000504294 ENST00000508385 ENST00000513020 ENST00000511663(uc010icn.2)
    ENST00000512014 ENST00000513095 ENST00000502260 ENST00000511185 ENST00000435136
    ENST00000508338 ENST00000511747 ENST00000509677
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    Additional mRNA sequence: 

    AB000462.1 AF000936.1 AK124073.1 AK225497.1 AK299996.1 AK307106.1 AK312286.1 BC022996.1 
    L37198.1 U56386.1 

    21 DOTS entries:

    DT.97801635  DT.454424  DT.100761526  DT.95111500  DT.95111475  DT.100761523  DT.121232491  DT.100773501 
    DT.100761530  DT.92430343  DT.95111470  DT.95344938  DT.100747139  DT.121232473  DT.121232516  DT.121244845 
    DT.92430341  DT.95352426  DT.97767357  DT.99975478  DT.100761525 

    Selected AceView cDNA sequences (see all 187):

    AK124073 BU527612 CF456690 BC022996 AW514297 BU629042 AW139011 BQ072759 
    AI093427 CA436549 BM923179 BE465238 AU133371 BU680159 BX505033 AI424336 
    AW292318 AW449314 BM669593 AW469668 BM973429 CF887402 BM715322 CA436871 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SH3BP2 (see all 25)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ·
    SP1:                                                                                                                                                        -   
    SP2:                                                                                                              -                             -           -   
    SP3:                                -     -     -     -     -     -     -     -     -     -     -     -     -     -                             -           -   
    SP4:                                                                                                                                                            
    SP5:                                                                                -     -     -     -     -     -                             -           -   

    ExUns: 17c · 17d ^ 18 ^ 19a · 19b · 19c · 19d ^ 20a · 20b · 20c ^ 21a · 21b · 21c ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28
    SP1:  -     -     -     -                       -                                                                             -         
    SP2:  -     -     -     -                       -                                                                             -         
    SP3:  -     -     -     -                       -                                                                             -         
    SP4:                                                                                                                          -         
    SP5:  -     -     -     -                       -                                                                                       


    ECgene alternative splicing isoforms for SH3BP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SH3BP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGGGTGAG
    SH3BP2 Expression
    About this image

    SH3BP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SH3BP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.167679

    UniProtKB/Swiss-Prot: 3BP2_HUMAN, P78314
    Tissue specificity: Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SH3BP2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sh3bp21 , 5 SH3-domain binding protein 21, 5 82.49(n)1
    85.2(a)1
      5 (17.89 cM)5
    240551  NM_001145859.11  NP_001139331.11 
     345258385 
    chicken
    (Gallus gallus)
    Aves SH3BP21 SH3-domain binding protein 2 63.61(n)
    64.23(a)
      422883  NM_001031165.1  NP_001026336.1 
    lizard
    (Anolis carolinensis)
    Reptilia SH3BP26
    SH3-domain binding protein 2
    52(a)
    1 ↔ 1
    5(80317289-80335642)
    zebrafish
    (Danio rerio)
    Actinopterygii sh3bp26
    SH3-domain binding protein 2
    48(a)
    1 ↔ 1
    10(15250215-15272781) ENSDARG00000021982


    ENSEMBL Gene Tree for SH3BP2 (if available)
    TreeFam Gene Tree for SH3BP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SH3BP2 (see all 1358)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0132614
    Cherubism (CRBM)4--see VAR_0132612 P R mis40--------
    VAR_0132584
    Cherubism (CRBM)4--see VAR_0132582 R Q mis40--------
    VAR_0132604
    Cherubism (CRBM)4--see VAR_0132602 P L mis40--------
    VAR_0132574
    Cherubism (CRBM)4--see VAR_0132572 R P mis40--------
    VAR_0132594
    Cherubism (CRBM)4--see VAR_0132592 P H mis40--------
    rs1219091491,2
    Cpathogenic12833300(+) CAGGCA/C/GATCAC 12 Q P R mis10--------
    rs1219091461,2
    Cpathogenic12833309(+) ACCCCA/C/G/
            
    CGATG
    16 H P R L mis10--------
    rs1432981111,2
    --2774058(+) GGGGCC/TCTGTT 1 -- int10--------
    rs1835171291,2
    --2774059(+) GGGCCC/TTGTTG 1 -- int10--------
    rs784336111,2
    C,F--2774072(+) TGAAGA/GCTCTC 1 -- int12Minor allele frequency- G:0.10CSA WA 120

    HapMap Linkage Disequilibrium report for SH3BP2 (2794750 - 2842825 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SH3BP2 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv915e199CNV Deletion23128226
    esv2726861CNV Deletion23290073
    esv2726859CNV Deletion23290073
    esv2726858CNV Deletion23290073
    esv2726835CNV Deletion23290073
    esv2726863CNV Deletion23290073
    esv2726860CNV Deletion23290073
    nsv461162CNV Loss19166990
    nsv878452CNV Loss21882294
    nsv878444CNV Loss21882294

    Human Gene Mutation Database (HGMD): SH3BP2
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SH3BP2
    DNA2.0 Custom Variant and Variant Library Synthesis for SH3BP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602104   
    OMIM disorders: 118400  
    UniProtKB/Swiss-Prot: 3BP2_HUMAN, P78314
  • Cherubism (CRBM) [MIM:118400]: An autosomal dominant syndrome characterized by excessive bone degradation
    of the upper and lower jaws, which often begins around three years of age. It is followed by development of
    fibrous tissue masses, which causes a characteristic facial swelling. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 2 diseases for SH3BP2:    
    About MalaCards
    cherubism    giant cell reparative granuloma

    2 diseases from the University of Copenhagen DISEASES database for SH3BP2:
    Cherubism     Giant cell reparative granuloma

    Find genes that share disorders with SH3BP2           About GenesLikeMe

    3 Novoseek inferred disease relationships for SH3BP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cherubism 97.9 40 14577811 (4), 16836910 (3), 12900899 (3), 16713042 (3) (see all 18)
    central giant cell granuloma 81.2 2 16713042 (2)
    granuloma giant cell 77.4 1 16713042 (1)

    GeneTests: SH3BP2
    GeneReviews: SH3BP2
    Genetic Association Database (GAD): SH3BP2
    Human Genome Epidemiology (HuGE) Navigator: SH3BP2 (2 documents)

    Export disorders for SH3BP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SH3BP2 gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with SH3BP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in the gene encoding c-Abl-binding protein SH3BP2 cause cherubism. (PubMed id 11381256)1, 2, 3, 9 Ueki Y.... Reichenberger E. (Nat. Genet. 2001)
    2. Identification and characterization of the human homologue of SH3BP2, an SH3 binding domain protein within a common region of deletion at 4p16.3 involved in bladder cancer. (PubMed id 9299232)1, 2, 3 Bell S.M.... Knowles M.A. (Genomics 1997)
    3. A missense mutation in the SH3BP2 gene on chromosome 4p16.3 found in a case of nonfamilial cherubism. (PubMed id 14577811)1, 2, 9 Imai Y....Yamada A. (Cleft Palate Craniofac. J. 2003)
    4. Novel mutation in the gene encoding c-Abl-binding protein SH3BP2 causes cherubism. (PubMed id 12900899)1, 2, 9 Lo B....Teebi A.S. (Am. J. Med. Genet. A 2003)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The primary structure and genomic organization of five novel transcripts located close to the Huntington's disease gene on human chromosome 4p16.3. (PubMed id 9734812)1, 2 Hadano S.... Ikeda J.-E. (DNA Res. 1998)
    9. Tyrosine phosphorylation of 3BP2 regulates B cell receptor-mediated activation of NFAT. (PubMed id 19833725)1, 9 Shukla U....Sada K. (J. Biol. Chem. 2009)
    10. [Gene mutation and expression of SH-3BP-2 in cherubism]. (PubMed id 19576004)1, 9 Li Y.W....Gao P. (Zhonghua Kou Qiang Yi Xue Za Zhi 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6452 HGNC: 10825 AceView: SH3BP2 Ensembl:ENSG00000087266 euGenes: HUgn6452
    ECgene: SH3BP2 Kegg: 6452 H-InvDB: SH3BP2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SH3BP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SH3BP2 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=SH3BP2[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SH3BP2 gene:
    Search GeneIP for patents involving SH3BP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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