SH3BP1 Gene
protein-coding GIFtS: 50
GCID: GC22P038030
|
|
SH3-domain binding protein 1
| |
Aliases
for SH3BP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SH3-Domain Binding Protein 11 2 | | ARHGAP431 2 | | 3BP-12 3 | | SH3 Domain Binding Protein 12 | | SH3 Domain-Binding Protein 12 |
Export aliases for SH3BP1 gene to outside databasesPrevious GC identifers: GC22P034651 GC22P036280 GC22P036278 GC22P036361 GC22P021002 |
Summaries
for SH3BP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: 3BP1_HUMAN, Q9Y3L3Function: Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This proteinbinds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not forRho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac (By similarity)
Gene Wiki entry for SH3BP1
|
Genomic Views
for SH3BP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SH3BP1 gene promoter:
NF-1 NF-1/L p53 Egr-1 Nkx2-5 GATA-2 YY1 PPAR-gamma1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SH3BP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH3BP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q13.1 HGNC cytogenetic band: 22q13.1SH3BP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P038030: view genomic region
(about GC identifiers)
Start:
|
38,030,661 bp from pter |
End:
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38,062,939 bp from pter |
Size:
|
32,279 bases |
Orientation:
|
plus strand |
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Proteins
for SH3BP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: 3BP1_HUMAN, Q9Y3L3 (See
protein sequence)Recommended Name: SH3 domain-binding protein 1 Size: 701 amino acids; 75713 Da
Sequence caution: Sequence=AAH08282.1; Type=Erroneous initiation; Sequence=BAC85842.1; Type=Erroneous initiation;Sequence=BAC85842.1; Type=Erroneous termination; Positions=56; Note=Translated as Cys;
Secondary accessions: Q5R3N0 Q6IBZ2 Q6ZVL9 Q96HQ5 Q9NSQ9Alternative splicing: 2 isoforms: Q9Y3L3-1 Q9Y3L3-2 Explore the universe of human proteins at neXtProt for SH3BP1: NX_Q9Y3L3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y3L3
SH3BP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061830.3
ENSEMBL proteins: ENSP00000411979 ENSP00000350018 ENSP00000401076 ENSP00000395126 ENSP00000337213
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
SH3BP1 for ontologies About GeneDecksing
SH3BP1 Antibody Products:
Assay Products for SH3BP1: |
Protein
Domains /
Families
for SH3BP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SH3BP1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y3L3ProtoNet protein and cluster: Q9Y3L3 1 Blocks protein family: IPB000198 RhoGAP domain
UniProtKB/Swiss-Prot: 3BP1_HUMAN, Q9Y3L3Similarity: Contains 1 BAR domainSimilarity: Contains 1 Rho-GAP domain |
Function
for SH3BP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: 3BP1_HUMAN, Q9Y3L3Function: Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This proteinbinds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not forRho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac (By similarity) Genatlas biochemistry entry for SH3BP1:SH3-domain binding protein 1
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH3BP1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3BP1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005096 | GTPase activator activity |
IEA | -- | | GO:0017124 | SH3 domain binding |
IEA | -- |
SH3BP1 for ontologies About GeneDecksing
|
Pathways & Interactions
for SH3BP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SH3BP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/15 Interacting proteins for SH3BP1 (Q9Y3L32, 3 ENSP000003500184) via UniProtKB, MINT, STRING, and/or I2D (see all 15)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
IEA | -- |
SH3BP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SH3BP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SH3BP1
Search CenterWatch for drugs/clinical trials and news about SH3BP1 / 3BP1
|
Transcripts
for SH3BP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SH3BP1 gene: NM_018957.3 Unigene Cluster for SH3BP1: SH3-domain binding protein 1 Hs.601143 [show with all ESTs]Unigene Representative Sequence: AK12437010 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000417536(uc003atg.1 uc011anl.1 uc003ath.1) ENST00000357436(uc003ati.3)
ENST00000451997(uc003atj.1) ENST00000469947(uc003atk.1) ENST00000495174
ENST00000471650 ENST00000459646 ENST00000466097 ENST00000442465 ENST00000336738
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH3BP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH3BP1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SH3BP1 (NM_018957) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SH3BP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH3BP1 |
Additional cDNA sequence: AK124370.1 AK126556.1 AK301163.1 AL157480.1 AY364241.1 BC008282.1 CR456576.1 9 DOTS entries: DT.433857 DT.95307361 DT.97864103 DT.97818332 DT.100047168 DT.120664702 DT.100778273 DT.100835803 DT.95368350 24/335 AceView cDNA sequences (see all 335): AA036699 BQ689646 BP350008 AY125047 H55465 CR617992 CR620574 BC064922 BC018844 BC008282 CR593618 BC000320 AI276553 CA309348 CA436893 CR617653 BX456404 CR456576 BM695047 BM909859 AK126873 CR601934 BX387308 BG683228
GeneLoc Exon Structure
|
Expression
for SH3BP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SH3BP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SH3BP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SH3BP1
SOURCE GeneReport for Unigene cluster: Hs.601143
SABiosciences Custom PCR Arrays for SH3BP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SH3BP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SH3BP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SH3BP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SH3BP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3BP1 |
Orthologs
for SH3BP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SH3BP1 gene from 5/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SH3BP11 |
SH3-domain binding protein 1 |
68.47(n)
66.08(a) |
|
430939 XM_428489.3 XP_428489.3 |
lizard
(Anolis carolinensis) |
Reptilia |
SH3BP16SRGAP26(see all 3) |
-- |
59(a)15(a)(see all 3) |
1 ↔ 1possible ortholog(see all 3) |
5(23774178-23795639) AAWZ02038242(5370-9744) |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.20712 |
Danio rerio cDNA clone MGC56011 IMAGE3819817, complete cds less |
70.09(n) |
|
AY391472.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
RhoGAP92B3 |
GTPase activator |
28(a) |
|
92B6 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
Y34B4A.86 |
-- |
21(a) |
1 → many |
X(5271811-5275250) |
ENSEMBL Gene Tree for SH3BP1 (if available)
TreeFam Gene Tree for SH3BP1 (if available) |
Paralogs
for SH3BP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SH3BP1 gene
- SRGAP12 ARHGAP52 ARHGAP172 ARHGAP242 ARHGAP222 ARHGAP352 SRGAP32 ARHGAP442
- ARHGAP42 SRGAP22 ARHGAP252
18/29 SIMAP similar genes for SH3BP1 using alignment to 5 protein entries: 3BP1_HUMAN (see all proteins)
(see all similar genes):PDXP DOCK8 KIAA0101 KIAA1651 ARL6IP5 RRM2B
PARK2 SH2B3 RPS6KA5 C1orf143 EEF1E1 ATL2
COQ5 TUBA1C ADCK1 DYNC2LI1 IK CHN2
SH3BP1 for paralogs About GeneDecksing
|
Genomic Variants
for SH3BP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SH3BP1 (38030661 - 38062939 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SH3BP1
1 CNV: 4128 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SH3BP1 |
|
Disorders
/ Diseases
for SH3BP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SH3BP1 for disorders About GeneDecksing
1  disease for SH3BP1: About MalaCardswiskott-aldrich syndrome
Export disorders for SH3BP1 gene to outside databases
|
Publications
for SH3BP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SH3BP1 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with SH3BP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I....O'Brien K.P. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1. (PubMed id 12029088)1, 3 Scott M.P....Miller W.T. (2002)
- Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex. (PubMed id 22891260)1 Elbediwy A....Balda M.S. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
|
External Searches for SH3BP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SH3BP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SH3BP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SH3BP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SH3BP1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SH3BP1 gene:
Search GeneIP for patents involving SH3BP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SH3BP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for SH3BP1 | | OriGene shRNA RFP for SH3BP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SH3BP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SH3BP1 | | | OriGene Protein Over-expression Lysate for SH3BP1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SH3BP1 | | OriGene 3'-UTR Clone for SH3BP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH3BP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH3BP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SH3BP1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | SH3BP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3BP1 |
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