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Aliases for SH3BP1 Gene

Aliases for SH3BP1 Gene

  • SH3 Domain Binding Protein 1 2 3
  • SH3-Domain Binding Protein 1 3 5
  • 3BP-1 3 4
  • ARHGAP43 3

External Ids for SH3BP1 Gene

Previous GeneCards Identifiers for SH3BP1 Gene

  • GC22P034651
  • GC22P036280
  • GC22P036278
  • GC22P036361
  • GC22P038030
  • GC22P021002

Summaries for SH3BP1 Gene

GeneCards Summary for SH3BP1 Gene

SH3BP1 (SH3 Domain Binding Protein 1) is a Protein Coding gene. GO annotations related to this gene include GTPase activator activity and SH3 domain binding. An important paralog of this gene is SRGAP3.

UniProtKB/Swiss-Prot for SH3BP1 Gene

  • Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac (By similarity).

Gene Wiki entry for SH3BP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3BP1 Gene

Genomics for SH3BP1 Gene

Regulatory Elements for SH3BP1 Gene

Promoters for SH3BP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SH3BP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SH3BP1 Gene

Chromosome:
22
Start:
37,634,654 bp from pter
End:
37,666,932 bp from pter
Size:
32,279 bases
Orientation:
Plus strand

Genomic View for SH3BP1 Gene

Genes around SH3BP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3BP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3BP1 Gene

Proteins for SH3BP1 Gene

  • Protein details for SH3BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3L3-3BP1_HUMAN
    Recommended name:
    SH3 domain-binding protein 1
    Protein Accession:
    Q9Y3L3
    Secondary Accessions:
    • Q5R3N0
    • Q6IBZ2
    • Q6ZVL9
    • Q96HQ5
    • Q9NSQ9

    Protein attributes for SH3BP1 Gene

    Size:
    701 amino acids
    Molecular mass:
    75713 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH08282.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC85842.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC85842.1; Type=Erroneous termination; Positions=56; Note=Translated as Cys.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SH3BP1 Gene

    Alternative splice isoforms for SH3BP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH3BP1 Gene

Proteomics data for SH3BP1 Gene at MOPED

Post-translational modifications for SH3BP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH3BP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SH3BP1 Gene

Domains & Families for SH3BP1 Gene

Gene Families for SH3BP1 Gene

Protein Domains for SH3BP1 Gene

Suggested Antigen Peptide Sequences for SH3BP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y3L3

UniProtKB/Swiss-Prot:

3BP1_HUMAN :
  • Contains 1 BAR domain.
Domain:
  • Contains 1 BAR domain.
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with SH3BP1: view

Function for SH3BP1 Gene

Molecular function for SH3BP1 Gene

GENATLAS Biochemistry:
SH3-domain binding protein 1
UniProtKB/Swiss-Prot Function:
Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac (By similarity).

Gene Ontology (GO) - Molecular Function for SH3BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with SH3BP1: view
genes like me logo Genes that share phenotypes with SH3BP1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SH3BP1

CRISPR Products

miRNA for SH3BP1 Gene

miRTarBase miRNAs that target SH3BP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH3BP1 Gene

Localization for SH3BP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SH3BP1 Gene COMPARTMENTS Subcellular localization image for SH3BP1 gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SH3BP1 Gene

Pathways & Interactions for SH3BP1 Gene

SuperPathways for SH3BP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SH3BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with SH3BP1: view

No data available for Pathways by source and SIGNOR curated interactions for SH3BP1 Gene

Drugs & Compounds for SH3BP1 Gene

No Compound Related Data Available

Transcripts for SH3BP1 Gene

Unigene Clusters for SH3BP1 Gene

SH3-domain binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SH3BP1 Gene

No ASD Table

Relevant External Links for SH3BP1 Gene

GeneLoc Exon Structure for
SH3BP1
ECgene alternative splicing isoforms for
SH3BP1

Expression for SH3BP1 Gene

mRNA expression in normal human tissues for SH3BP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH3BP1 Gene

This gene is overexpressed in Whole Blood (x9.8).

Protein differential expression in normal tissues from HIPED for SH3BP1 Gene

This gene is overexpressed in Lymph node (27.0) and Peripheral blood mononuclear cells (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SH3BP1 Gene



SOURCE GeneReport for Unigene cluster for SH3BP1 Gene Hs.601143

genes like me logo Genes that share expression patterns with SH3BP1: view

Protein tissue co-expression partners for SH3BP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SH3BP1 Gene

Orthologs for SH3BP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3BP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SH3BP1 35
  • 87.59 (n)
  • 88.17 (a)
SH3BP1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SH3BP1 35
  • 87.93 (n)
  • 88.6 (a)
SH3BP1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sh3bp1 35
  • 85.14 (n)
  • 86.64 (a)
Sh3bp1 16
Sh3bp1 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SH3BP1 35
  • 99.05 (n)
  • 99 (a)
SH3BP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sh3bp1 35
  • 82.99 (n)
  • 83.28 (a)
oppossum
(Monodelphis domestica)
Mammalia SH3BP1 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SH3BP1 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves SH3BP1 35
  • 69.64 (n)
  • 66.49 (a)
-- 36
  • 63 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SH3BP1 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3bp1 35
  • 56.98 (n)
  • 49.66 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.2071 35
sh3bp1 35
  • 57.67 (n)
  • 53.98 (a)
sh3bp1 36
  • 41 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12938 35
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP92B 37
  • 28 (a)
RhoGAP92B 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y34B4A.8 36
  • 22 (a)
OneToMany
Species with no ortholog for SH3BP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3BP1 Gene

ENSEMBL:
Gene Tree for SH3BP1 (if available)
TreeFam:
Gene Tree for SH3BP1 (if available)

Paralogs for SH3BP1 Gene

genes like me logo Genes that share paralogs with SH3BP1: view

Variants for SH3BP1 Gene

Sequence variations from dbSNP and Humsavar for SH3BP1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_033450 -
VAR_033451 -
rs916277 -- 37,639,555(+) CGGGG(A/G/T)AGAGC upstream-variant-2KB
rs4820292 -- 37,638,746(+) GTAAA(A/C)CCAGC upstream-variant-2KB
rs6000851 -- 37,639,301(+) CTTGG(C/T)ACCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SH3BP1 Gene

Variant ID Type Subtype PubMed ID
nsv829203 CNV Loss 20364138
nsv834191 CNV Loss 17160897
dgv4964n71 CNV Loss 21882294
nsv471197 CNV Loss 18288195
dgv4965n71 CNV Loss 21882294
nsv915035 CNV Loss 21882294
dgv1406e1 CNV Complex 17122850
nsv915038 CNV Loss 21882294

Variation tolerance for SH3BP1 Gene

Residual Variation Intolerance Score: 43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.20; 69.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH3BP1 Gene

HapMap Linkage Disequilibrium report
SH3BP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3BP1 Gene

Disorders for SH3BP1 Gene

Relevant External Links for SH3BP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SH3BP1

No disorders were found for SH3BP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3BP1 Gene

Publications for SH3BP1 Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4 67
  2. Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1. (PMID: 12029088) Scott M.P. … Miller W.T. (J. Biol. Chem. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. An image-based RNAi screen identifies SH3BP1 as a key effector of Semaphorin 3E-PlexinD1 signaling. (PMID: 24841563) Tata A. … Gu C. (J. Cell Biol. 2014) 3

Products for SH3BP1 Gene

Sources for SH3BP1 Gene

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