Aliases for SH3BP1 Gene
External Ids for SH3BP1 Gene
Previous GeneCards Identifiers for SH3BP1 Gene
This gene encodes a member of the Rho GTPase activating protein (RhoGAP) family. The encoded protein regulates Rac signaling and plays a role in cytoskeletal dynamics, cell motility and epithelial junction formation. This protein's association with the exocyst complex, which tethers secretory vesicles to the plasma membrane, has been demonstrated to be important in cell motility. In a distinct complex, this protein has been shown to regulate epithelial junction formation and morphogenesis. By interacting with the Plexin-D1 cell surface receptor, this protein mediates changes in the cytoskeleton in response to semaphorin binding. This protein may promote metastasis in human liver cancer cells and tissues. [provided by RefSeq, Mar 2017]
GeneCards Summary for SH3BP1 Gene
SH3BP1 (SH3 Domain Binding Protein 1) is a Protein Coding gene. GO annotations related to this gene include GTPase activator activity and SH3 domain binding. An important paralog of this gene is ARHGAP17.
UniProtKB/Swiss-Prot for SH3BP1 Gene
Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac (By similarity).