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Aliases for SH3BP1 Gene

Aliases for SH3BP1 Gene

  • SH3 Domain Binding Protein 1 2 3 5
  • 3BP-1 3 4
  • SH3 Domain-Binding Protein 1 3
  • ARHGAP43 3

External Ids for SH3BP1 Gene

Previous GeneCards Identifiers for SH3BP1 Gene

  • GC22P034651
  • GC22P036280
  • GC22P036278
  • GC22P036361
  • GC22P038030
  • GC22P021002

Summaries for SH3BP1 Gene

Entrez Gene Summary for SH3BP1 Gene

  • This gene encodes a member of the Rho GTPase activating protein (RhoGAP) family. The encoded protein regulates Rac signaling and plays a role in cytoskeletal dynamics, cell motility and epithelial junction formation. This protein's association with the exocyst complex, which tethers secretory vesicles to the plasma membrane, has been demonstrated to be important in cell motility. In a distinct complex, this protein has been shown to regulate epithelial junction formation and morphogenesis. By interacting with the Plexin-D1 cell surface receptor, this protein mediates changes in the cytoskeleton in response to semaphorin binding. This protein may promote metastasis in human liver cancer cells and tissues. [provided by RefSeq, Mar 2017]

GeneCards Summary for SH3BP1 Gene

SH3BP1 (SH3 Domain Binding Protein 1) is a Protein Coding gene. GO annotations related to this gene include GTPase activator activity and SH3 domain binding. An important paralog of this gene is ARHGAP17.

UniProtKB/Swiss-Prot for SH3BP1 Gene

  • Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac (By similarity).

Gene Wiki entry for SH3BP1 Gene

Additional gene information for SH3BP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3BP1 Gene

Genomics for SH3BP1 Gene

Regulatory Elements for SH3BP1 Gene

Enhancers for SH3BP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H037630 1.3 ENCODE dbSUPER 41 +1.9 1936 11 HDGF PKNOX1 ARID4B DMAP1 ZNF143 FOS SP3 SP5 ZHX2 MXD4 SH3BP1 GGA1 GCAT LGALS2 GC22M042210
GH22H037672 1.9 FANTOM5 Ensembl ENCODE dbSUPER 15 +40.9 40906 6 HDGF ARNT ARID4B SIN3A ZNF2 SLC30A9 ZNF766 FOS SP3 SP5 GGA1 SH3BP1 LOC101927051 DDX17 H1F0 GCAT CYTH4 RAC2 GC22M042251 LGALS1
GH22H037657 1.7 FANTOM5 ENCODE dbSUPER 12.2 +25.5 25508 5 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 GGA1 LOC101927051 SH3BP1 DDX17 GC22M042196 GC22P037667
GH22H037606 1.7 FANTOM5 ENCODE dbSUPER 12 -25.3 -25297 4 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 GGA1 SH3BP1 EIF3L DDX17 H1F0 GC22P037617 PIR36618
GH22H037601 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -32.8 -32797 1 TBP PKNOX1 FOXA2 ATF1 ZEB1 SCRT2 FOS EGR2 THAP11 SP3 GGA1 SH3BP1 LGALS2 TRIOBP GC22P037603
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SH3BP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SH3BP1 Gene

Chromosome:
22
Start:
37,634,654 bp from pter
End:
37,666,932 bp from pter
Size:
32,279 bases
Orientation:
Plus strand

Genomic View for SH3BP1 Gene

Genes around SH3BP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3BP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3BP1 Gene

Proteins for SH3BP1 Gene

  • Protein details for SH3BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3L3-3BP1_HUMAN
    Recommended name:
    SH3 domain-binding protein 1
    Protein Accession:
    Q9Y3L3
    Secondary Accessions:
    • Q5R3N0
    • Q6IBZ2
    • Q6ZVL9
    • Q96HQ5
    • Q9NSQ9

    Protein attributes for SH3BP1 Gene

    Size:
    701 amino acids
    Molecular mass:
    75713 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH08282.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC85842.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC85842.1; Type=Erroneous termination; Positions=56; Note=Translated as Cys.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SH3BP1 Gene

    Alternative splice isoforms for SH3BP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH3BP1 Gene

Post-translational modifications for SH3BP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH3BP1 Gene

No data available for DME Specific Peptides for SH3BP1 Gene

Domains & Families for SH3BP1 Gene

Gene Families for SH3BP1 Gene

Protein Domains for SH3BP1 Gene

Suggested Antigen Peptide Sequences for SH3BP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SH3BP1: view

No data available for UniProtKB/Swiss-Prot for SH3BP1 Gene

Function for SH3BP1 Gene

Molecular function for SH3BP1 Gene

GENATLAS Biochemistry:
SH3-domain binding protein 1
UniProtKB/Swiss-Prot Function:
Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac (By similarity).

Phenotypes From GWAS Catalog for SH3BP1 Gene

Gene Ontology (GO) - Molecular Function for SH3BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IMP 22891260
GO:0005515 protein binding IPI 21044950
GO:0017124 SH3 domain binding IEA --
GO:0030215 semaphorin receptor binding IPI 24841563
genes like me logo Genes that share ontologies with SH3BP1: view
genes like me logo Genes that share phenotypes with SH3BP1: view

Animal Model Products

CRISPR Products

miRNA for SH3BP1 Gene

miRTarBase miRNAs that target SH3BP1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SH3BP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH3BP1 Gene

Localization for SH3BP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH3BP1 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SH3BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 colocalizes_with exocyst IDA 21658605
GO:0001891 phagocytic cup IDA 26465210
GO:0005634 nucleus IDA 22891260
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 22891260
genes like me logo Genes that share ontologies with SH3BP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SH3BP1 Gene

Pathways & Interactions for SH3BP1 Gene

SuperPathways for SH3BP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SH3BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006911 phagocytosis, engulfment IMP 26465210
GO:0007015 actin filament organization IMP 22891260
GO:0007165 signal transduction IEA --
GO:0016477 cell migration IMP 21658605
GO:0030834 regulation of actin filament depolymerization IMP 24841563
genes like me logo Genes that share ontologies with SH3BP1: view

No data available for Pathways by source and SIGNOR curated interactions for SH3BP1 Gene

Drugs & Compounds for SH3BP1 Gene

No Compound Related Data Available

Transcripts for SH3BP1 Gene

Unigene Clusters for SH3BP1 Gene

SH3-domain binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SH3BP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SH3BP1 Gene

No ASD Table

Relevant External Links for SH3BP1 Gene

GeneLoc Exon Structure for
SH3BP1
ECgene alternative splicing isoforms for
SH3BP1

Expression for SH3BP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SH3BP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH3BP1 Gene

This gene is overexpressed in Whole Blood (x9.8).

Protein differential expression in normal tissues from HIPED for SH3BP1 Gene

This gene is overexpressed in Lymph node (27.0) and Peripheral blood mononuclear cells (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SH3BP1 Gene



Protein tissue co-expression partners for SH3BP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SH3BP1 Gene:

SH3BP1

SOURCE GeneReport for Unigene cluster for SH3BP1 Gene:

Hs.601143

Evidence on tissue expression from TISSUES for SH3BP1 Gene

  • Liver(4.2)
  • Pancreas(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with SH3BP1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SH3BP1 Gene

Orthologs for SH3BP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3BP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SH3BP1 33 34
  • 99.05 (n)
dog
(Canis familiaris)
Mammalia SH3BP1 33 34
  • 87.93 (n)
cow
(Bos Taurus)
Mammalia SH3BP1 33 34
  • 87.59 (n)
mouse
(Mus musculus)
Mammalia Sh3bp1 33 16 34
  • 85.14 (n)
rat
(Rattus norvegicus)
Mammalia Sh3bp1 33
  • 82.99 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SH3BP1 34
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SH3BP1 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves SH3BP1 33
  • 69.64 (n)
-- 34
  • 69 (a)
OneToMany
-- 34
  • 63 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SH3BP1 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3bp1 33
  • 56.98 (n)
zebrafish
(Danio rerio)
Actinopterygii sh3bp1 33 34
  • 57.67 (n)
Dr.2071 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12938 33
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP92B 35 34
  • 28 (a)
worm
(Caenorhabditis elegans)
Secernentea Y34B4A.8 34
  • 22 (a)
OneToMany
Species where no ortholog for SH3BP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3BP1 Gene

ENSEMBL:
Gene Tree for SH3BP1 (if available)
TreeFam:
Gene Tree for SH3BP1 (if available)

Paralogs for SH3BP1 Gene

Variants for SH3BP1 Gene

Sequence variations from dbSNP and Humsavar for SH3BP1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000079638 -- 37,642,824(+) GGAGA(A/G)GCCCC intron-variant, nc-transcript-variant
rs1000128341 -- 37,640,816(+) AAAGA(A/C/G)GCTTC intron-variant
rs1000396072 -- 37,651,668(+) GGCTT(C/T)GTGGT intron-variant
rs1000802436 -- 37,649,500(+) AGAAA(C/T)AGGCC intron-variant
rs1000829990 -- 37,641,546(+) AGGTC(A/G)GGGCT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SH3BP1 Gene

Variant ID Type Subtype PubMed ID
esv2758838 CNV loss 17122850
nsv1057617 CNV gain 25217958
nsv1072636 CNV deletion 25765185
nsv471197 CNV loss 18288195
nsv589006 CNV loss 21841781
nsv829203 CNV loss 20364138
nsv834191 CNV loss 17160897

Variation tolerance for SH3BP1 Gene

Residual Variation Intolerance Score: 43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.20; 69.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH3BP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SH3BP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3BP1 Gene

Disorders for SH3BP1 Gene

Relevant External Links for SH3BP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SH3BP1

No disorders were found for SH3BP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3BP1 Gene

Publications for SH3BP1 Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1. (PMID: 12029088) Scott MP … Miller WT (The Journal of biological chemistry 2002) 2 3 60

Products for SH3BP1 Gene

Sources for SH3BP1 Gene

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