Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SH3BGRL3 Gene

protein-coding   GIFtS: 50
GCID: GC01P026605

SH3 domain binding glutamic acid-rich protein like 3

 Explore 1 disease affiliated with
SH3BGRL3 via our new
 Human Malady Compendium 
Biological research products
for SH3BGRL3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
SH3 Domain Binding Glutamic Acid-Rich Protein Like 31 2     SH3 Domain-Binding Glutamic Acid-Rich-Like Protein 32
SH3BP-12 3     SH3BGRL3-Like Protein2
SH3 Domain-Binding Protein 12 3     TNF Inhibitory Protein2
TIP-B12     

External Ids:    HGNC: 155681   Entrez Gene: 834422   Ensembl: ENSG000001426697   UniProtKB: Q9H2993   

Export aliases for SH3BGRL3 gene to outside databases

Previous GC identifers: GC01P026086 GC01P025627 GC01P025838 GC01P026211 GC01P026289 GC01P026478 GC01P024860


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SH3L3_HUMAN, Q9H299
Function: Could act as a modulator of glutaredoxin biological activity

Gene Wiki entry for SH3BGRL3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SH3BGRL3 gene promoter:
         AML1a   FOXO3   Lmo2   FOXO3b   YY1   GATA-1   CREB   deltaCREB   FOXO3a   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSH3BGRL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SH3BGRL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH3BGRL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.11

SH3BGRL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SH3BGRL3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P026605:  view genomic region     (about GC identifiers)

Start:
26,605,667 bp from pter      End:
26,608,013 bp from pter
Size:
2,347 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SH3L3_HUMAN, Q9H299 (See protein sequence)
Recommended Name: SH3 domain-binding glutamic acid-rich-like protein 3  
Size: 93 amino acids; 10438 Da
Subcellular location: Cytoplasm. Nucleus
1 PDB 3D structure from and Proteopedia for SH3BGRL3:
1SJ6 (3D)    
Secondary accessions: Q5T122

Explore the universe of human proteins at neXtProt for SH3BGRL3: NX_Q9H299

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H299

  • SH3BGRL3 Protein expression data from MOPED and PaxDb:    About this image 
    SH3BGRL3 Protein Expression
    REFSEQ proteins: NP_112576.1  
    ENSEMBL proteins: 
     ENSP00000270792   ENSP00000363358  

    Human Recombinant Protein Products for SH3BGRL3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SH3BGRL3
    OriGene Protein Over-expression Lysate: SH3BGRL3
    OriGene Custom Protein Services for SH3BGRL3 
    GenScript Custom Purified and Recombinant Proteins Services for SH3BGRL3
    Novus Biologicals SH3BGRL3 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for SH3BGRL3
    Uscn Proteins for SH3BGRL3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--

    SH3BGRL3 for ontologies           About GeneDecksing



    SH3BGRL3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SH3BGRL3 
    GenScript Custom Superior Antibodies Services for SH3BGRL3
    Novus Biologicals SH3BGRL3 Antibody
    Abcam antibodies for SH3BGRL3 
    Uscn Antibodies for SH3BGRL3
    ThermoFisher Antibodies for SH3BGRL3

    Assay Products for SH3BGRL3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SH3BGRL3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SH3BGRL3


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SH3BGRL3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006993 Glut_rich_SH3-bd
     IPR002109 Glutaredoxin
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry Q9H299

    ProtoNet protein and cluster: Q9H299

    1 Blocks protein family: IPB006993 SH3-binding

    UniProtKB/Swiss-Prot: SH3L3_HUMAN, Q9H299
    Similarity: Belongs to the SH3BGR family
    Similarity: Contains 1 glutaredoxin domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SH3L3_HUMAN, Q9H299
    Function: Could act as a modulator of glutaredoxin biological activity

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009055electron carrier activity IEA--
    GO:0015035protein disulfide oxidoreductase activity IEA--
         
    SH3BGRL3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SH3BGRL3 

    miRNA
    Products:
        
    miRTarBase miRNAs that target SH3BGRL3:
    hsa-mir-1 (MIRT001334)

    OriGene 3'-UTR Clone: SH3BGRL3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SH3BGRL3
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate SH3BGRL3 (see all 14):
    hsa-miR-206 hsa-miR-205 hsa-miR-409-3p hsa-miR-1271 hsa-miR-3617 hsa-miR-1 hsa-miR-744* hsa-miR-744
    SwitchGear 3'UTR luciferase reporter plasmidSH3BGRL3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SH3BGRL3 (see all 7)
    OriGene shRNA RFP: SH3BGRL3
    OriGene siRNA: SH3BGRL3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SH3BGRL3
    Sirion Biotech Custom design and validation of potent shRNA sequences against SH3BGRL3 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SH3BGRL3
    Sirion Biotech Customized adenovirus for overexpression of SH3BGRL3 
    Sirion Biotech Customized adenovirus for potent knockdown of SH3BGRL3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH3BGRL3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH3BGRL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SH3BGRL3 (NM_031286)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SH3BGRL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH3BGRL3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SH3BGRL3
    Search LifeMap BioReagents cell lines for SH3BGRL3
    Sirion Biotech Customized stable knockdown cell line services for SH3BGRL3 
    Sirion Biotech Customized inducible knockdown cell line services for SH3BGRL3
    Sirion Biotech Customized stable overexpressing cell line services for SH3BGRL3
    Sirion Biotech Customized inducible overexpressing cell line services for SH3BGRL3

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3BGRL3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SH3BGRL3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for SH3BGRL3 (Q9H2992, 3 ENSP000002707924) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046262, 3MINT-61509 I2D: score=3 
    EGFRP005333, ENSP000002754934I2D: score=3 STRING: ENSP00000275493
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045454cell redox homeostasis IEA--

    SH3BGRL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SH3BGRL3
    Search CenterWatch for drugs/clinical trials and news about SH3BGRL3 / SH3L3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SH3BGRL3 gene: 
    NM_031286.3  

    Unigene Cluster for SH3BGRL3:

    SH3 domain binding glutamic acid-rich protein like 3
    Hs.109051  [show with all ESTs]
    Unigene Representative Sequence: AF466367
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000270792(uc001blu.3) ENST00000319041

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: SH3BGRL3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SH3BGRL3
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate SH3BGRL3 (see all 14):
    hsa-miR-206 hsa-miR-205 hsa-miR-409-3p hsa-miR-1271 hsa-miR-3617 hsa-miR-1 hsa-miR-744* hsa-miR-744
    SwitchGear 3'UTR luciferase reporter plasmidSH3BGRL3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SH3BGRL3 (see all 7)
    OriGene shRNA RFP: SH3BGRL3
    OriGene siRNA: SH3BGRL3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SH3BGRL3
    Sirion Biotech Custom design and validation of potent shRNA sequences against SH3BGRL3 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH3BGRL3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH3BGRL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SH3BGRL3 (NM_031286)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SH3BGRL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH3BGRL3 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SH3BGRL3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SH3BGRL3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SH3BGRL3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SH3BGRL3

    Additional cDNA sequence: 

    AF247790.1 AF304163.1 AF466367.1 AJ297915.1 AK024884.1 BC030135.2 

    11 DOTS entries:

    DT.99951838  DT.219230  DT.100653292  DT.95103190  DT.97777475  DT.95103214  DT.95097544  DT.100768711 
    DT.121392308  DT.80100150  DT.40107440 

    24/610 AceView cDNA sequences (see all 610):

    CA444290 BM768563 CR612702 CN485119 BF342199 BM851453 BM788495 AA580797 
    AW591773 AL133609 BQ643284 BQ706373 CB137404 BF058492 BM818166 BU165090 
    AA496458 CB127424 AI969104 BX422034 BG832213 AI969753 BM709842 BU634281 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SH3BGRL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGGACCTTT
    SH3BGRL3 Expression
    About this image

    SH3BGRL3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    EyeInner Nuclear LayerMature Rod Bipolar CellsBipolar, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SH3BGRL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SH3BGRL3

    SOURCE GeneReport for Unigene cluster: Hs.109051

    UniProtKB/Swiss-Prot: SH3L3_HUMAN, Q9H299
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for SH3BGRL3
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SH3BGRL3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SH3BGRL3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SH3BGRL3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SH3BGRL3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3BGRL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SH3BGRL3 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SH3BGRL31 SH3 domain binding glutamic acid-rich protein like more 84.23(n)
    90.32(a)
      768795  XM_001231580.2  XP_001231581.1 
    lizard
    (Anolis carolinensis)
    Reptilia SH3BGRL36
    --
    85(a)
    1 ↔ 1
    GL343480.1(448001-453696)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.204412 Transcribed sequence with weak similarity to protein more 73.78(n)    137716071 
    zebrafish
    (Danio rerio)
    Actinopterygii sh3bgrl31 SH3 domain binding glutamic acid-rich protein like more 64.81(n)
    61.11(a)
      393248  NM_200278.1  NP_956572.1 


    ENSEMBL Gene Tree for SH3BGRL3 (if available)
    TreeFam Gene Tree for SH3BGRL3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SH3BGRL3 gene
    SH3BGRL22  SH3BGRL2  SH3BGR2  
    3 SIMAP similar genes for SH3BGRL3 using alignment to 3 protein entries:     SH3L3_HUMAN (see all proteins):
    SH3BGRL2    SH3BGRL    SH3BGR

    SH3BGRL3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SH3BGRL3
    PGOHUM00000263162


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/44 NCBI SNPs in SH3BGRL3 are shown (see all 44    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1116920071,2
    C--26606029(+) GGGGG-/AAAAAT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1899642701,2
    --26606047(+) CATGGG/TCTCTT 1 -- us2k10--------
    rs109027321,2
    C,F,A,H--26606174(+) TTCCAA/CAGCCC 1 -- us2k1 ese319Minor allele frequency- C:0.12NS EA NA WA CSA 2226
    rs763162551,2
    F--26606187(+) AGCTTC/TCCTGT 1 -- us2k11Minor allele frequency- T:0.02EA 120
    rs1816009471,2
    --26606213(+) CCTCCC/TGGAGA 1 -- ut510--------
    rs617750821,2
    C,F--26606291(+) CCAGAC/TCNNNN 1 -- ut513Minor allele frequency- T:0.16NA 124
    rs1865376481,2
    --26606424(+) TGCGCA/GCCTGG 1 -- ut510--------
    rs1149136991,2
    F--26606763(+) CTAGCG/ACCCGG 1 -- int11Minor allele frequency- A:0.04WA 118
    rs1151529571,2
    F--26606769(+) CCCGGG/AACCCA 1 -- int11Minor allele frequency- A:0.04WA 118
    rs1167740941,2
    C,F--26606887(+) GGGTCC/TTTTGC 1 -- int11Minor allele frequency- T:0.04WA 118

    HapMap Linkage Disequilibrium report for SH3BGRL3 (26605667 - 26608013 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SH3BGRL3: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SH3BGRL3
    DNA2.0 Custom Variant and Variant Library Synthesis for SH3BGRL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SH3BGRL3 for disorders           About GeneDecksing

    1 disease for SH3BGRL3:    About MalaCards
    brain cancer

    2 Novoseek disease relationships for SH3BGRL3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 14.6 2 15907482 (1)
    tumors 4.65 2 15907482 (1)


    Export disorders for SH3BGRL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SH3BGRL3 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with SH3BGRL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NMR structure and regulated expression in APL cell of human SH3BGRL3. (PubMed id 15907482)1, 2, 9 Xu C.... Shi Y. (2005)
    2. A novel human homologue of the SH3BGR gene encodes a small protein similar to glutaredoxin 1 of Escherichia coli. (PubMed id 11444877)1, 2, 9 Mazzocco M.... Scartezzini P. (2001)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83442 HGNC: 15568 AceView: DKFZP434L0117andSH3BGRL3 Ensembl:ENSG00000142669 euGenes: HUgn83442
    ECgene: SH3BGRL3 H-InvDB: SH3BGRL3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SH3BGRL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SH3BGRL3 gene:
    Search GeneIP for patents involving SH3BGRL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SH3BGRL3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SH3BGRL3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SH3BGRL3  
     OriGene Protein Over-expression Lysate for SH3BGRL3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SH3BGRL3   OriGene 3'-UTR Clone for SH3BGRL3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH3BGRL3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH3BGRL3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for SH3BGRL3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SH3BGRL3   OriGene Custom Protein Services for SH3BGRL3  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SH3BGRL3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SH3BGRL3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH3BGRL3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SH3BGRL3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SH3BGRL3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SH3BGRL3
     GenScript Custom Purified and Recombinant Proteins Services for SH3BGRL3 GenScript cDNA clones with any tag delivered in your preferred vector for SH3BGRL3
     GenScript Custom Assay Services for SH3BGRL3 GenScript Custom Superior Antibodies Services for SH3BGRL3
     GenScript Custom overexpressing Cell Line Services for SH3BGRL3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SH3BGRL3 promoter
     Search Chromatin IP Primers for SH3BGRL3
     RT2 qPCR Primer Assay in human, mouse, rat SH3BGRL3
     GNC Network for SH3BGRL3
     SABiosciences Custom PCR Arrays for SH3BGRL3
     Search Tocris compounds for SH3BGRL3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SH3BGRL3 antibodies
     SH3BGRL3 lysates
     Antibodies for SH3BGRL3
     See all of Abcam's Antibodies, Kits and Proteins for SH3BGRL3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for SH3BGRL3




     SH3BGRL3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SH3BGRL3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3BGRL3
     SwitchGear 3'UTR luciferase reporter plasmids for SH3BGRL3
     SwitchGear Promoter luciferase reporter plasmids for SH3BGRL3
     ThermoFisher Antibodies for SH3BGRL3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH3BGRL3
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SH3BGRL3
    Sirion Biotech Customized:
     stable knockdown cell line services for SH3BGRL3
     inducible knockdown cell line services for SH3BGRL3
     design and validation of potent shRNA sequences against SH3BGRL3
     adenovirus for potent knockdown of SH3BGRL3
     adenovirus for overexpression of SH3BGRL3
     stable overexpressing cell line services for SH3BGRL3
     inducible overexpressing cell line services for SH3BGRL3
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SH3BGRL3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4