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Aliases for SH3BGRL3 Gene

Aliases for SH3BGRL3 Gene

  • SH3 Domain Binding Glutamate Rich Protein Like 3 2 3 5
  • SH3 Domain Binding Glutamic Acid-Rich Protein Like 3 2 3
  • SH3 Domain-Binding Protein 1 3 4
  • SH3BP-1 3 4
  • SH3 Domain-Binding Glutamic Acid-Rich-Like Protein 3 3
  • Epididymis Secretory Protein Li 297 3
  • TNF Inhibitory Protein 3
  • SH3BGRL3-Like Protein 3
  • HEL-S-297 3
  • TIP-B1 3

External Ids for SH3BGRL3 Gene

Previous GeneCards Identifiers for SH3BGRL3 Gene

  • GC01P026086
  • GC01P025627
  • GC01P025838
  • GC01P026211
  • GC01P026478
  • GC01P026605
  • GC01P024860

Summaries for SH3BGRL3 Gene

GeneCards Summary for SH3BGRL3 Gene

SH3BGRL3 (SH3 Domain Binding Glutamate Rich Protein Like 3) is a Protein Coding gene. GO annotations related to this gene include GTPase activator activity and protein disulfide oxidoreductase activity. An important paralog of this gene is SH3BGRL2.

UniProtKB/Swiss-Prot for SH3BGRL3 Gene

  • Could act as a modulator of glutaredoxin biological activity.

Gene Wiki entry for SH3BGRL3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3BGRL3 Gene

Genomics for SH3BGRL3 Gene

Regulatory Elements for SH3BGRL3 Gene

Enhancers for SH3BGRL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G026313 1.4 FANTOM5 ENCODE 17.5 +39.0 38994 8.4 HDGF PKNOX1 ATF1 WRNIP1 ARID4B BRCA1 ZNF2 ZNF48 ZNF766 GATA2 CD52 UBXN11 SH3BGRL3 ZNF683 CRYBG2 LIN28A CEP85 ENSG00000236782 ZNF593 FAM110D
GH01G026274 2 FANTOM5 Ensembl ENCODE dbSUPER 3.2 +4.7 4718 19.1 CREB3L1 AGO1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D ZNF610 GLIS1 CD52 UBXN11 CEP85 HMGN2 TRIM63 FAM110D NPM1P39 CRYBG2 CNKSR1 RPS6KA1
GH01G026618 2.1 FANTOM5 Ensembl ENCODE dbSUPER 3 +341.2 341220 4.0 CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 HMGN2 ACTG1P20 ZNF593 AHDC1 LOC101928324 WASF2 NPM1P39 RPL17P9 ARID1A PIGV
GH01G026581 1.8 FANTOM5 Ensembl ENCODE dbSUPER 1.5 +303.8 303776 2.1 HNRNPUL1 ARID4B ZNF48 YY1 FOS PAF1 MXD4 JUNB MIER2 TBX21 MIR1976 RPS6KA1 SFN ENSG00000226698 UBXN11 GPATCH3 NUDC PIGV SH3BGRL3 RN7SL679P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SH3BGRL3 on UCSC Golden Path with GeneCards custom track

Promoters for SH3BGRL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SH3BGRL3 Gene

26,279,176 bp from pter
26,281,522 bp from pter
2,347 bases
Plus strand

Genomic View for SH3BGRL3 Gene

Genes around SH3BGRL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3BGRL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3BGRL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3BGRL3 Gene

Proteins for SH3BGRL3 Gene

  • Protein details for SH3BGRL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH3 domain-binding glutamic acid-rich-like protein 3
    Protein Accession:
    Secondary Accessions:
    • Q5T122

    Protein attributes for SH3BGRL3 Gene

    93 amino acids
    Molecular mass:
    10438 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SH3BGRL3 Gene

neXtProt entry for SH3BGRL3 Gene

Post-translational modifications for SH3BGRL3 Gene

  • Ubiquitination at Lys18
  • Modification sites at PhosphoSitePlus

Other Protein References for SH3BGRL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SH3BGRL3 Gene

Domains & Families for SH3BGRL3 Gene

Protein Domains for SH3BGRL3 Gene

Suggested Antigen Peptide Sequences for SH3BGRL3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SH3BGR family.
  • Belongs to the SH3BGR family.
genes like me logo Genes that share domains with SH3BGRL3: view

No data available for Gene Families for SH3BGRL3 Gene

Function for SH3BGRL3 Gene

Molecular function for SH3BGRL3 Gene

UniProtKB/Swiss-Prot Function:
Could act as a modulator of glutaredoxin biological activity.

Gene Ontology (GO) - Molecular Function for SH3BGRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IMP 24841563
GO:0009055 electron carrier activity IEA --
GO:0015035 protein disulfide oxidoreductase activity IEA --
GO:0030215 semaphorin receptor binding IPI 24841563
genes like me logo Genes that share ontologies with SH3BGRL3: view
genes like me logo Genes that share phenotypes with SH3BGRL3: view

Animal Models for SH3BGRL3 Gene

MGI Knock Outs for SH3BGRL3:

Animal Model Products

CRISPR Products

miRNA for SH3BGRL3 Gene

miRTarBase miRNAs that target SH3BGRL3

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SH3BGRL3 Gene

Localization for SH3BGRL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH3BGRL3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH3BGRL3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SH3BGRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA,IBA --
GO:0016604 nuclear body IDA --
GO:0030027 lamellipodium IDA 24841563
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SH3BGRL3: view

Pathways & Interactions for SH3BGRL3 Gene

SuperPathways for SH3BGRL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SH3BGRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030834 regulation of actin filament depolymerization IMP 24841563
GO:0032956 regulation of actin cytoskeleton organization IMP 24841563
GO:0043535 regulation of blood vessel endothelial cell migration IMP 24841563
GO:0043547 positive regulation of GTPase activity IMP 24841563
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with SH3BGRL3: view

No data available for Pathways by source and SIGNOR curated interactions for SH3BGRL3 Gene

Drugs & Compounds for SH3BGRL3 Gene

No Compound Related Data Available

Transcripts for SH3BGRL3 Gene

mRNA/cDNA for SH3BGRL3 Gene

Unigene Clusters for SH3BGRL3 Gene

SH3 domain binding glutamic acid-rich protein like 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3BGRL3 Gene

No ASD Table

Relevant External Links for SH3BGRL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH3BGRL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SH3BGRL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH3BGRL3 Gene

This gene is overexpressed in Whole Blood (x14.1).

Protein differential expression in normal tissues from HIPED for SH3BGRL3 Gene

This gene is overexpressed in Platelet (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SH3BGRL3 Gene

Protein tissue co-expression partners for SH3BGRL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SH3BGRL3 Gene:


SOURCE GeneReport for Unigene cluster for SH3BGRL3 Gene:


mRNA Expression by UniProt/SwissProt for SH3BGRL3 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for SH3BGRL3 Gene

  • Lung(4.5)
  • Pancreas(4.4)
  • Skin(4.4)
  • Liver(4.3)
  • Nervous system(3.3)
  • Intestine(2.5)
  • Blood(2.4)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with SH3BGRL3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SH3BGRL3 Gene

Orthologs for SH3BGRL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3BGRL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SH3BGRL3 34 35
  • 99.28 (n)
(Canis familiaris)
Mammalia SH3BGRL3 34 35
  • 96.42 (n)
(Bos Taurus)
Mammalia SH3BGRL3 34 35
  • 96.06 (n)
(Mus musculus)
Mammalia Sh3bgrl3 34 16 35
  • 91.4 (n)
(Rattus norvegicus)
Mammalia Sh3bgrl3 34
  • 90.32 (n)
(Monodelphis domestica)
Mammalia SH3BGRL3 35
  • 90 (a)
(Gallus gallus)
Aves SH3BGRL3 34 35
  • 84.23 (n)
(Anolis carolinensis)
Reptilia SH3BGRL3 35
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3bgrl3 34
  • 65.17 (n)
Str.20441 34
(Danio rerio)
Actinopterygii sh3bgrl3 34 35
  • 64.84 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sh3beta 35
  • 8 (a)
(Caenorhabditis elegans)
Secernentea Y105E8A.1 35
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 13 (a)
Species where no ortholog for SH3BGRL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3BGRL3 Gene

Gene Tree for SH3BGRL3 (if available)
Gene Tree for SH3BGRL3 (if available)

Paralogs for SH3BGRL3 Gene

Paralogs for SH3BGRL3 Gene

(4) SIMAP similar genes for SH3BGRL3 Gene using alignment to 3 proteins: Pseudogenes for SH3BGRL3 Gene

genes like me logo Genes that share paralogs with SH3BGRL3: view

Variants for SH3BGRL3 Gene

Sequence variations from dbSNP and Humsavar for SH3BGRL3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000159614 -- 26,280,296(+) GACGG(A/G)GGCGG intron-variant
rs1001179765 -- 26,280,488(+) ACCAC(G/T)ACCGC intron-variant
rs1001649479 -- 26,279,433(+) CCAGC(C/T)GTCAG upstream-variant-2KB
rs1001804078 -- 26,279,712(+) TAGAG(C/T)ACCTC upstream-variant-2KB
rs1002219626 -- 26,279,771(+) CTGTG(C/T)GCGGC utr-variant-5-prime

Variation tolerance for SH3BGRL3 Gene

Residual Variation Intolerance Score: 70.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH3BGRL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SH3BGRL3 Gene

Disorders for SH3BGRL3 Gene

Relevant External Links for SH3BGRL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SH3BGRL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3BGRL3 Gene

Publications for SH3BGRL3 Gene

  1. NMR structure and regulated expression in APL cell of human SH3BGRL3. (PMID: 15907482) Xu C. … Shi Y. (FEBS Lett. 2005) 3 4 22 64
  2. A novel human homologue of the SH3BGR gene encodes a small protein similar to glutaredoxin 1 of Escherichia coli. (PMID: 11444877) Mazzocco M. … Scartezzini P. (Biochem. Biophys. Res. Commun. 2001) 3 4 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64
  5. SH3BGRL3 Protein as a Potential Prognostic Biomarker for Urothelial Carcinoma: A Novel Binding Partner of Epidermal Growth Factor Receptor. (PMID: 26286913) Chiang C.Y. … Chow N.H. (Clin. Cancer Res. 2015) 3 64

Products for SH3BGRL3 Gene

Sources for SH3BGRL3 Gene

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