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Aliases for SH3BGRL3 Gene

Aliases for SH3BGRL3 Gene

  • SH3 Domain Binding Glutamate Rich Protein Like 3 2 3 5
  • SH3 Domain Binding Glutamic Acid-Rich Protein Like 3 2 3
  • SH3 Domain-Binding Protein 1 3 4
  • SH3BP-1 3 4
  • SH3 Domain-Binding Glutamic Acid-Rich-Like Protein 3 3
  • Epididymis Secretory Protein Li 297 3
  • TNF Inhibitory Protein 3
  • SH3BGRL3-Like Protein 3
  • HEL-S-297 3
  • TIP-B1 3

External Ids for SH3BGRL3 Gene

Previous GeneCards Identifiers for SH3BGRL3 Gene

  • GC01P026086
  • GC01P025627
  • GC01P025838
  • GC01P026211
  • GC01P026478
  • GC01P026605
  • GC01P024860

Summaries for SH3BGRL3 Gene

GeneCards Summary for SH3BGRL3 Gene

SH3BGRL3 (SH3 Domain Binding Glutamate Rich Protein Like 3) is a Protein Coding gene. GO annotations related to this gene include GTPase activator activity and protein disulfide oxidoreductase activity. An important paralog of this gene is SH3BGRL2.

UniProtKB/Swiss-Prot for SH3BGRL3 Gene

  • Could act as a modulator of glutaredoxin biological activity.

Gene Wiki entry for SH3BGRL3 Gene

Additional gene information for SH3BGRL3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3BGRL3 Gene

Genomics for SH3BGRL3 Gene

Regulatory Elements for SH3BGRL3 Gene

Enhancers for SH3BGRL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H026618 2.1 FANTOM5 Ensembl ENCODE dbSUPER 12 +341.2 341220 4 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 ZFP41 MEF2D ZNF610 ARID1A HMGN2 ACTG1P20 GPN2 ZNF593 AHDC1 GPATCH3 RPS6KA1 SELENON LOC101928324
GH01H026313 1.4 FANTOM5 ENCODE 17.5 +39.0 38994 8.4 HDGF PKNOX1 ATF1 SIN3A ARID4B BRCA1 ZNF2 ZNF766 GATA2 ZNF143 CD52 UBXN11 SH3BGRL3 ZNF683 CRYBG2 LIN28A CEP85 ENSG00000236782 ZNF593 FAM110D
GH01H026110 1.4 ENCODE dbSUPER 10.6 -166.8 -166793 4.2 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ZNF143 GPN2 ARID1A TRIM63 LOC101928324 GPATCH3 ENSG00000261349 HMGN2 LOC101928728 SH3BGRL3 RPS6KA1
GH01H025817 1.4 ENCODE dbSUPER 10.5 -459.1 -459145 4.7 HNRNPUL1 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 MTFR1L SELENON ARID1A HMGN2 LOC101928324 ENSG00000261349 SYF2 PIGV SH3BGRL3 LOC101928728
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SH3BGRL3 on UCSC Golden Path with GeneCards custom track

Promoters for SH3BGRL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for SH3BGRL3 Gene

Genomic Locations for SH3BGRL3 Gene
2,347 bases
Plus strand

Genomic View for SH3BGRL3 Gene

Genes around SH3BGRL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3BGRL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3BGRL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3BGRL3 Gene

Proteins for SH3BGRL3 Gene

  • Protein details for SH3BGRL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH3 domain-binding glutamic acid-rich-like protein 3
    Protein Accession:
    Secondary Accessions:
    • Q5T122

    Protein attributes for SH3BGRL3 Gene

    93 amino acids
    Molecular mass:
    10438 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SH3BGRL3 Gene

neXtProt entry for SH3BGRL3 Gene

Post-translational modifications for SH3BGRL3 Gene

  • Ubiquitination at isoforms=18
  • Modification sites at PhosphoSitePlus

Other Protein References for SH3BGRL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SH3BGRL3 Gene

Domains & Families for SH3BGRL3 Gene

Gene Families for SH3BGRL3 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SH3BGRL3 Gene

Suggested Antigen Peptide Sequences for SH3BGRL3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SH3BGR family.
  • Belongs to the SH3BGR family.
genes like me logo Genes that share domains with SH3BGRL3: view

Function for SH3BGRL3 Gene

Molecular function for SH3BGRL3 Gene

UniProtKB/Swiss-Prot Function:
Could act as a modulator of glutaredoxin biological activity.

Phenotypes From GWAS Catalog for SH3BGRL3 Gene

Gene Ontology (GO) - Molecular Function for SH3BGRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009055 electron carrier activity IEA --
GO:0015035 protein disulfide oxidoreductase activity IEA --
GO:0030215 semaphorin receptor binding IPI --
genes like me logo Genes that share ontologies with SH3BGRL3: view
genes like me logo Genes that share phenotypes with SH3BGRL3: view

Animal Models for SH3BGRL3 Gene

MGI Knock Outs for SH3BGRL3:

Animal Model Products

miRNA for SH3BGRL3 Gene

miRTarBase miRNAs that target SH3BGRL3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SH3BGRL3 Gene

Localization for SH3BGRL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH3BGRL3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH3BGRL3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3
mitochondrion 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SH3BGRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
GO:0016604 nuclear body IDA --
GO:0030027 lamellipodium IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SH3BGRL3: view

Pathways & Interactions for SH3BGRL3 Gene

SuperPathways for SH3BGRL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SH3BGRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030834 regulation of actin filament depolymerization IMP --
GO:0032956 regulation of actin cytoskeleton organization IMP --
GO:0043535 regulation of blood vessel endothelial cell migration IMP --
GO:0043547 positive regulation of GTPase activity IMP --
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with SH3BGRL3: view

No data available for Pathways by source and SIGNOR curated interactions for SH3BGRL3 Gene

Drugs & Compounds for SH3BGRL3 Gene

No Compound Related Data Available

Transcripts for SH3BGRL3 Gene

mRNA/cDNA for SH3BGRL3 Gene

Unigene Clusters for SH3BGRL3 Gene

SH3 domain binding glutamic acid-rich protein like 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3BGRL3 Gene

No ASD Table

Relevant External Links for SH3BGRL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH3BGRL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SH3BGRL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH3BGRL3 Gene

This gene is overexpressed in Whole Blood (x14.1).

Protein differential expression in normal tissues from HIPED for SH3BGRL3 Gene

This gene is overexpressed in Platelet (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SH3BGRL3 Gene

Protein tissue co-expression partners for SH3BGRL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SH3BGRL3 Gene:


SOURCE GeneReport for Unigene cluster for SH3BGRL3 Gene:


mRNA Expression by UniProt/SwissProt for SH3BGRL3 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for SH3BGRL3 Gene

  • Lung(4.5)
  • Pancreas(4.4)
  • Skin(4.4)
  • Liver(4.3)
  • Nervous system(3.3)
  • Intestine(2.5)
  • Blood(2.4)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with SH3BGRL3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SH3BGRL3 Gene

Orthologs for SH3BGRL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3BGRL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SH3BGRL3 33 34
  • 99.28 (n)
(Canis familiaris)
Mammalia SH3BGRL3 33 34
  • 96.42 (n)
(Bos Taurus)
Mammalia SH3BGRL3 33 34
  • 96.06 (n)
(Mus musculus)
Mammalia Sh3bgrl3 33 16 34
  • 91.4 (n)
(Rattus norvegicus)
Mammalia Sh3bgrl3 33
  • 90.32 (n)
(Monodelphis domestica)
Mammalia SH3BGRL3 34
  • 90 (a)
(Gallus gallus)
Aves SH3BGRL3 33 34
  • 84.23 (n)
(Anolis carolinensis)
Reptilia SH3BGRL3 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3bgrl3 33
  • 65.17 (n)
Str.20441 33
(Danio rerio)
Actinopterygii sh3bgrl3 33 34
  • 64.84 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sh3beta 34
  • 8 (a)
(Caenorhabditis elegans)
Secernentea Y105E8A.1 34
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 13 (a)
Species where no ortholog for SH3BGRL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3BGRL3 Gene

Gene Tree for SH3BGRL3 (if available)
Gene Tree for SH3BGRL3 (if available)

Paralogs for SH3BGRL3 Gene

Paralogs for SH3BGRL3 Gene

(4) SIMAP similar genes for SH3BGRL3 Gene using alignment to 3 proteins: Pseudogenes for SH3BGRL3 Gene

genes like me logo Genes that share paralogs with SH3BGRL3: view

Variants for SH3BGRL3 Gene

Sequence variations from dbSNP and Humsavar for SH3BGRL3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000159614 -- 26,280,296(+) GACGG(A/G)GGCGG intron-variant
rs1001179765 -- 26,280,488(+) ACCAC(G/T)ACCGC intron-variant
rs1001649479 -- 26,279,433(+) CCAGC(C/T)GTCAG upstream-variant-2KB
rs1001804078 -- 26,279,712(+) TAGAG(C/T)ACCTC upstream-variant-2KB
rs1002219626 -- 26,279,771(+) CTGTG(C/T)GCGGC utr-variant-5-prime

Variation tolerance for SH3BGRL3 Gene

Residual Variation Intolerance Score: 70.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH3BGRL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SH3BGRL3 Gene

Disorders for SH3BGRL3 Gene

Relevant External Links for SH3BGRL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SH3BGRL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3BGRL3 Gene

Publications for SH3BGRL3 Gene

  1. NMR structure and regulated expression in APL cell of human SH3BGRL3. (PMID: 15907482) Xu C … Shi Y (FEBS letters 2005) 3 4 22 60
  2. A novel human homologue of the SH3BGR gene encodes a small protein similar to Glutaredoxin 1 of Escherichia coli. (PMID: 11444877) Mazzocco M … Scartezzini P (Biochemical and biophysical research communications 2001) 3 4 22 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. SH3BGRL3 Protein as a Potential Prognostic Biomarker for Urothelial Carcinoma: A Novel Binding Partner of Epidermal Growth Factor Receptor. (PMID: 26286913) Chiang CY … Chow NH (Clinical cancer research : an official journal of the American Association for Cancer Research 2015) 3 60
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome AS … Carapito C (Proteomics 2015) 4 60

Products for SH3BGRL3 Gene

Sources for SH3BGRL3 Gene

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