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Aliases for SH3BGRL2 Gene

Aliases for SH3BGRL2 Gene

  • SH3 Domain Binding Glutamate Rich Protein Like 2 2 3
  • SH3 Domain Binding Glutamic Acid-Rich Protein Like 2 2
  • SH3 Domain Binding Glutamate-Rich Protein Like 2 5
  • Fovea-Associated SH3 Domain-Binding Protein 4
  • FASH3 4

External Ids for SH3BGRL2 Gene

Previous GeneCards Identifiers for SH3BGRL2 Gene

  • GC06P080283
  • GC06P080336
  • GC06P080397
  • GC06P077561

Summaries for SH3BGRL2 Gene

GeneCards Summary for SH3BGRL2 Gene

SH3BGRL2 (SH3 Domain Binding Glutamate Rich Protein Like 2) is a Protein Coding gene. GO annotations related to this gene include SH3 domain binding and protein disulfide oxidoreductase activity. An important paralog of this gene is SH3BGRL3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3BGRL2 Gene

Genomics for SH3BGRL2 Gene

Regulatory Elements for SH3BGRL2 Gene

Promoters for SH3BGRL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SH3BGRL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SH3BGRL2 Gene

Chromosome:
6
Start:
79,631,283 bp from pter
End:
79,703,670 bp from pter
Size:
72,388 bases
Orientation:
Plus strand

Genomic View for SH3BGRL2 Gene

Genes around SH3BGRL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3BGRL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3BGRL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3BGRL2 Gene

Proteins for SH3BGRL2 Gene

  • Protein details for SH3BGRL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJC5-SH3L2_HUMAN
    Recommended name:
    SH3 domain-binding glutamic acid-rich-like protein 2
    Protein Accession:
    Q9UJC5
    Secondary Accessions:
    • A8MQU2
    • Q2VPC2
    • Q5VV96
    • Q6NSK8
    • Q6P9E8
    • Q7Z734
    • Q8IWD3
    • Q9BPY5

    Protein attributes for SH3BGRL2 Gene

    Size:
    107 amino acids
    Molecular mass:
    12326 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SH3BGRL2 Gene

neXtProt entry for SH3BGRL2 Gene

Proteomics data for SH3BGRL2 Gene at MOPED

Post-translational modifications for SH3BGRL2 Gene

  • Ubiquitination at Lys 98
  • Modification sites at PhosphoSitePlus

Other Protein References for SH3BGRL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SH3BGRL2 Gene

Domains & Families for SH3BGRL2 Gene

Protein Domains for SH3BGRL2 Gene

Suggested Antigen Peptide Sequences for SH3BGRL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJC5

UniProtKB/Swiss-Prot:

SH3L2_HUMAN :
  • Belongs to the SH3BGR family.
Family:
  • Belongs to the SH3BGR family.
genes like me logo Genes that share domains with SH3BGRL2: view

No data available for Gene Families for SH3BGRL2 Gene

Function for SH3BGRL2 Gene

Phenotypes for SH3BGRL2 Gene

genes like me logo Genes that share phenotypes with SH3BGRL2: view

Animal Model Products

CRISPR Products

miRNA for SH3BGRL2 Gene

miRTarBase miRNAs that target SH3BGRL2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH3BGRL2 Gene

Localization for SH3BGRL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH3BGRL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SH3BGRL2 Gene COMPARTMENTS Subcellular localization image for SH3BGRL2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SH3BGRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SH3BGRL2: view

Pathways & Interactions for SH3BGRL2 Gene

SuperPathways for SH3BGRL2 Gene

No Data Available

Interacting Proteins for SH3BGRL2 Gene

Gene Ontology (GO) - Biological Process for SH3BGRL2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SH3BGRL2 Gene

Drugs & Compounds for SH3BGRL2 Gene

(1) Drugs for SH3BGRL2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SH3BGRL2: view

Transcripts for SH3BGRL2 Gene

mRNA/cDNA for SH3BGRL2 Gene

Unigene Clusters for SH3BGRL2 Gene

SH3 domain binding glutamic acid-rich protein like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SH3BGRL2 Gene

No ASD Table

Relevant External Links for SH3BGRL2 Gene

GeneLoc Exon Structure for
SH3BGRL2
ECgene alternative splicing isoforms for
SH3BGRL2

Expression for SH3BGRL2 Gene

mRNA expression in normal human tissues for SH3BGRL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SH3BGRL2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.7), Cervix (10.9), Salivary gland (7.7), and Platelet (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SH3BGRL2 Gene



SOURCE GeneReport for Unigene cluster for SH3BGRL2 Gene Hs.302772

mRNA Expression by UniProt/SwissProt for SH3BGRL2 Gene

Q9UJC5-SH3L2_HUMAN
Tissue specificity: Highly expressed in brain, placenta, liver and kidney. Expressed in retina.
genes like me logo Genes that share expression patterns with SH3BGRL2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for SH3BGRL2 Gene

Orthologs for SH3BGRL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3BGRL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SH3BGRL2 35
  • 92.45 (n)
  • 93.4 (a)
SH3BGRL2 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC474977 35
  • 94.39 (n)
  • 94.39 (a)
SH3BGRL2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sh3bgrl2 35
  • 88.47 (n)
  • 93.46 (a)
Sh3bgrl2 16
Sh3bgrl2 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SH3BGRL2 35
  • 99.69 (n)
  • 100 (a)
SH3BGRL2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102554622 35
  • 87.85 (n)
  • 93.46 (a)
oppossum
(Monodelphis domestica)
Mammalia SH3BGRL2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SH3BGRL2 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves SH3BGRL2 35
  • 80.77 (n)
  • 85.58 (a)
SH3BGRL2 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SH3BGRL2 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3bgrl2 35
  • 72.44 (n)
  • 73.08 (a)
Str.10801 35
zebrafish
(Danio rerio)
Actinopterygii sh3bgrl2 35
  • 68.73 (n)
  • 73.2 (a)
sh3bgrl2 36
  • 70 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1778 35
fruit fly
(Drosophila melanogaster)
Insecta Sh3beta 36
  • 8 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y105E8A.1 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for SH3BGRL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3BGRL2 Gene

ENSEMBL:
Gene Tree for SH3BGRL2 (if available)
TreeFam:
Gene Tree for SH3BGRL2 (if available)

Paralogs for SH3BGRL2 Gene

Paralogs for SH3BGRL2 Gene

(4) SIMAP similar genes for SH3BGRL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SH3BGRL2: view

Variants for SH3BGRL2 Gene

Sequence variations from dbSNP and Humsavar for SH3BGRL2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1503 -- 79,701,794(+) ATTCT(G/T)TTATC utr-variant-3-prime
rs1507 -- 79,701,855(+) AGCTG(A/C)CTTTA utr-variant-3-prime
rs8869 -- 79,703,520(-) TTCAG(C/G)AAACC utr-variant-3-prime
rs718943 -- 79,656,079(-) TAAAT(C/T)AGATG intron-variant
rs718944 -- 79,655,960(-) CAACT(A/C)CCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH3BGRL2 Gene

Variant ID Type Subtype PubMed ID
dgv6930n71 CNV Gain 21882294
nsv886304 CNV Gain 21882294
nsv5368 CNV Insertion 18451855
dgv1139e199 CNV Deletion 23128226

Variation tolerance for SH3BGRL2 Gene

Residual Variation Intolerance Score: 52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH3BGRL2 Gene

HapMap Linkage Disequilibrium report
SH3BGRL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3BGRL2 Gene

Disorders for SH3BGRL2 Gene

Relevant External Links for SH3BGRL2

Genetic Association Database (GAD)
SH3BGRL2
Human Genome Epidemiology (HuGE) Navigator
SH3BGRL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SH3BGRL2

No disorders were found for SH3BGRL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3BGRL2 Gene

Publications for SH3BGRL2 Gene

  1. The identification of a novel human homologue of the SH3 binding glutamic acid-rich (SH3BGR) gene establishes a new family of highly conserved small proteins related to Thioredoxin Superfamily. (PMID: 12095696) Mazzocco M. … Scartezzini P. (Gene 2002) 2 3 4 67
  2. Genetic loci associated with circulating levels of very long-chain saturated fatty acids. (PMID: 25378659) Lemaitre R.N. … Friedlander Y. (J. Lipid Res. 2015) 3
  3. Linkage and association of successful aging to the 6q25 region in large Amish kindreds. (PMID: 22773346) Edwards D.R. … Scott W.K. (Age (Dordr) 2013) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PMID: 23398456) Bett J.S. … Hay R.T. (Biochem. J. 2013) 3

Products for SH3BGRL2 Gene

Sources for SH3BGRL2 Gene

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