SH3BGRL2 Gene
protein-coding GIFtS: 48
GCID: GC06P080397
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|
SH3 domain binding glutamic acid-rich protein like 2
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Aliases for SH3BGRL2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| SH3 Domain Binding Glutamic Acid-Rich Protein Like 21 2 | | Fovea-Associated SH3 Domain-Binding Protein2 3 | | SH3 Domain-Binding Glutamic Acid-Rich-Like Protein 22 | | FASH33 |
Export aliases for SH3BGRL2 gene to outside databasesPrevious GC identifers: GC06P080283 GC06P080336 GC06P077561 |
Summaries for SH3BGRL2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| -- |
Genomic Views for SH3BGRL2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007299.13
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SH3BGRL2 gene promoter: HFH-3 HOXA9 HOXA9B MAZR Meis-1b FOXI1 Meis-1 En-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for SH3BGRL2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH3BGRL2 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q14.1 Ensembl cytogenetic band: 6q14.1 HGNC cytogenetic band: 6q14.1SH3BGRL2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P080397: view genomic region
(about GC identifiers)
Start:
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80,341,000 bp from pter |
End:
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80,413,372 bp from pter |
Size:
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72,373 bases |
Orientation:
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plus strand |
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Proteins for SH3BGRL2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: SH3L2_HUMAN, Q9UJC5 (See
protein sequence)Recommended Name: SH3 domain-binding glutamic acid-rich-like protein 2 Size: 107 amino acids; 12326 Da
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for SH3BGRL2:2CT6 (3D)
 
Secondary accessions: A8MQU2 Q2VPC2 Q5VV96 Q6NSK8 Q6P9E8 Q7Z734 Q8IWD3 Q9BPY5Explore the universe of human proteins at neXtProt for SH3BGRL2: NX_Q9UJC5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UJC5 SH3BGRL2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_113657.1 ENSEMBL proteins: ENSP00000358853 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SH3BGRL2 for ontologies About GeneDecksing
SH3BGRL2 Antibody Products: Assay Products for SH3BGRL2: |
Protein
Domains / Families for SH3BGRL2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SH3BGRL2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UJC5ProtoNet protein and cluster: Q9UJC5 1 Blocks protein family: IPB006993 SH3-binding
UniProtKB/Swiss-Prot: SH3L2_HUMAN, Q9UJC5Similarity: Belongs to the SH3BGR family |
Function for SH3BGRL2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH3BGRL2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH3BGRL2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SH3BGRL2 (NM_031469) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SH3BGRL2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH3BGRL2  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3BGRL2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0017124 | SH3 domain binding |
IEA | -- |
SH3BGRL2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for SH3BGRL2:
|
Pathways & Interactions for SH3BGRL2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SH3BGRL2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
 2 Interacting proteins for SH3BGRL2 (Q9UJC53 ENSP000003588534) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds for SH3BGRL2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SH3BGRL2 for compounds About GeneDecksing
Browse Tocris compounds for SH3BGRL2 1 Novoseek chemical compound relationship for SH3BGRL2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
37 |
4 |
9571151 (1), 10702676 (1), 9872323 (1) |
Search CenterWatch for drugs/clinical trials and news about SH3BGRL2 / SH3L2 
|
Transcripts for SH3BGRL2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for SH3BGRL2 gene: NM_031469.2 Unigene Cluster for SH3BGRL2: SH3 domain binding glutamic acid-rich protein like 2 Hs.302772 [show with all ESTs]Unigene Representative Sequence: AF3401511 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000369838(uc003piz.1)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH3BGRL2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH3BGRL2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SH3BGRL2 (NM_031469) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SH3BGRL2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH3BGRL2  |
Additional cDNA sequence: AF131754.1 AF340151.1 AJ297972.1 AK074506.1 AK307145.1 AK311757.1 BC040489.1 BC052987.1 BC060799.1 BC070059.1 BC109043.2 BC109044.2 7 DOTS entries: DT.91997496 DT.100820211 DT.91702006 DT.95169615 DT.121329356 DT.91817680 DT.40130256 24/200 AceView cDNA sequences (see all 200): AF131754 BM684195 CB178665 BM707822 BM719349 BM715253 CB243442 AI985579 AI188610 AI554117 BM680185 BM684721 BU151133 BM054709 AI916207 CB243471 AI468774 BX957072 AA344270 AW071119 BM930083 AI262420 AI094172 BU685270 GeneLoc Exon Structure
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Expression for SH3BGRL2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SH3BGRL2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TATGTATCCT
About this image See SH3BGRL2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SH3BGRL2
SOURCE GeneReport for Unigene cluster: Hs.302772 UniProtKB/Swiss-Prot: SH3L2_HUMAN, Q9UJC5Tissue specificity: Highly expressed in brain, placenta, liver and kidney. Expressed in retina SABiosciences Custom PCR Arrays for SH3BGRL2
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SH3BGRL2 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SH3BGRL2 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SH3BGRL2 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SH3BGRL2 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3BGRL2 |
Orthologs for SH3BGRL2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SH3BGRL2 gene from 6/18 species (see all 18) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
SH3BGRL21 |
SH3 domain binding glutamic acid-rich protein like more |
80.77(n) 85.58(a) |
  |
421851 XM_419869.3 XP_419869.3 |
lizard (Anolis carolinensis) |
Reptilia |
SH3BGRL26 |
-- |
63(a) |
1 ↔ 1 |
1(199480001-199492281) |
African clawed frog (Xenopus laevis) |
Amphibia |
BC056126.12 |
-- |
77.71(n) |
  |
BC056126.1 |
zebrafish (Danio rerio) |
Actinopterygii |
sh3bgrl21 |
SH3 domain binding glutamic acid-rich protein like more |
68.73(n) 73.2(a) |
  |
431744 NM_001002197.1 NP_001002197.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
Sh3beta6 |
Sh3beta |
8(a) |
1 → many |
3L(7357684-7362360) |
worm (Caenorhabditis elegans) |
Secernentea |
Y105E8A.16 |
-- |
28(a) |
1 → many |
I(14341621-14343793) |
ENSEMBL Gene Tree for SH3BGRL2 (if available) TreeFam Gene Tree for SH3BGRL2 (if available)  |
Paralogs for SH3BGRL2 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for SH3BGRL2 gene
- SH3BGRL2 SH3BGR2 SH3BGRL32
3 SIMAP similar genes for SH3BGRL2 using alignment to 1 protein entry: SH3L2_HUMAN:SH3BGRL SH3BGR SH3BGRL3
SH3BGRL2 for paralogs About GeneDecksing
|
Genomic Variants for SH3BGRL2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 6 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for SH3BGRL2 (80341000 - 80413372 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 4 variations for SH3BGRL2 1 CNV: 93845 3 Indels: 93846 81461 81462  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SH3BGRL2 |
|
Disorders
/ Diseases for SH3BGRL2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SH3BGRL2 for disorders About GeneDecksing
1 disease for SH3BGRL2: About MalaCardsgout Human Genome Epidemiology (HuGE) Navigator: SH3BGRL2 (2 documents) Export disorders for SH3BGRL2 gene to outside databases
|
Publications for SH3BGRL2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SH3BGRL2 gene, integrated from 9 sources (see all 24): (articles sorted by number of sources associating them with SH3BGRL2) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The identification of a novel human homologue of the SH3 binding glutamic acid-rich (SH3BGR) gene establishes a new family of highly conserved small proteins related to Thioredoxin Superfamily. (PubMed id 12095696)1, 2, 3 Mazzocco M.... Scartezzini P. (2002)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Linkage and association of successful aging to the 6q2 5 region in large Amish kindreds. (PubMed id 22773346)1 Edwards D.R....Scott W.K. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Common genetic variation and susceptibility to partia l epilepsies: a genome-wide association study. (PubMed id 20522523)1 KasperaviciAte D....Sisodiya S.M. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
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External Searches for SH3BGRL2 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SH3BGRL2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SH3BGRL2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SH3BGRL2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for SH3BGRL2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SH3BGRL2 gene: Search GeneIP for patents involving SH3BGRL2
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for SH3BGRL2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for SH3BGRL2 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SH3BGRL2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SH3BGRL2 | | OriGene Protein Over-expression Lysate for SH3BGRL2 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for SH3BGRL2 | | OriGene 3'-UTR Clone for SH3BGRL2 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH3BGRL2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH3BGRL2 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | OriGene Purified Protein for SH3BGRL2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SH3BGRL2 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SH3BGRL2 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH3BGRL2 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SH3BGRL2 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SH3BGRL2 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SH3BGRL2 |
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 | | SH3BGRL2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3BGRL2 |
|  |  |  | | | Search ThermoFisher Antibodies for SH3BGRL2 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH3BGRL2 |
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