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Aliases for SH3BGRL2 Gene

Aliases for SH3BGRL2 Gene

  • SH3 Domain Binding Glutamate-Rich Protein Like 2 2 3
  • SH3 Domain Binding Glutamic Acid-Rich Protein Like 2 2
  • Fovea-Associated SH3 Domain-Binding Protein 4
  • FASH3 4

External Ids for SH3BGRL2 Gene

Summaries for SH3BGRL2 Gene

GeneCards Summary for SH3BGRL2 Gene

SH3BGRL2 (SH3 Domain Binding Glutamate-Rich Protein Like 2) is a Protein Coding gene. GO annotations related to this gene include SH3 domain binding. An important paralog of this gene is SH3BGRL3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3BGRL2 Gene

Genomics for SH3BGRL2 Gene

Genomic Location for SH3BGRL2 Gene

79,631,283 bp from pter
79,703,659 bp from pter
72,377 bases
Plus strand

Genomic View for SH3BGRL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SH3BGRL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3BGRL2 Gene

Regulatory Elements for SH3BGRL2 Gene

Proteins for SH3BGRL2 Gene

  • Protein details for SH3BGRL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH3 domain-binding glutamic acid-rich-like protein 2
    Protein Accession:
    Secondary Accessions:
    • A8MQU2
    • Q2VPC2
    • Q5VV96
    • Q6NSK8
    • Q6P9E8
    • Q7Z734
    • Q8IWD3
    • Q9BPY5

    Protein attributes for SH3BGRL2 Gene

    107 amino acids
    Molecular mass:
    12326 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SH3BGRL2 Gene

neXtProt entry for SH3BGRL2 Gene

Proteomics data for SH3BGRL2 Gene at MOPED

Post-translational modifications for SH3BGRL2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys98

Other Protein References for SH3BGRL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SH3BGRL2 Gene

Domains for SH3BGRL2 Gene

Protein Domains for SH3BGRL2 Gene

Suggested Antigen Peptide Sequences for SH3BGRL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SH3BGR family.:
    • Q9UJC5
genes like me logo Genes that share domains with SH3BGRL2: view

No data available for Gene Families for SH3BGRL2 Gene

Function for SH3BGRL2 Gene

Gene Ontology (GO) - Molecular Function for SH3BGRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009055 electron carrier activity --
GO:0015035 protein disulfide oxidoreductase activity --
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with SH3BGRL2: view

Phenotypes for SH3BGRL2 Gene

GenomeRNAi human phenotypes for SH3BGRL2:
genes like me logo Genes that share phenotypes with SH3BGRL2: view

miRNA for SH3BGRL2 Gene

miRTarBase miRNAs that target SH3BGRL2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SH3BGRL2 Gene

Localization for SH3BGRL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH3BGRL2 Gene

Subcellular locations from

Jensen Localization Image for SH3BGRL2 Gene COMPARTMENTS Subcellular localization image for SH3BGRL2 gene
Compartment Confidence
nucleus 5
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SH3BGRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SH3BGRL2: view

Pathways for SH3BGRL2 Gene

SuperPathways for SH3BGRL2 Gene

No Data Available

Interacting Proteins for SH3BGRL2 Gene

Gene Ontology (GO) - Biological Process for SH3BGRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045454 cell redox homeostasis --
genes like me logo Genes that share ontologies with SH3BGRL2: view

No data available for Pathways by source for SH3BGRL2 Gene

Compounds for SH3BGRL2 Gene

(1) Novoseek inferred chemical compound relationships for SH3BGRL2 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 37 3
genes like me logo Genes that share compounds with SH3BGRL2: view

Transcripts for SH3BGRL2 Gene

mRNA/cDNA for SH3BGRL2 Gene

Unigene Clusters for SH3BGRL2 Gene

SH3 domain binding glutamic acid-rich protein like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SH3BGRL2 Gene

No ASD Table

Relevant External Links for SH3BGRL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH3BGRL2 Gene

mRNA expression in normal human tissues for SH3BGRL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SH3BGRL2 Gene

SOURCE GeneReport for Unigene cluster for SH3BGRL2 Gene Hs.302772

mRNA Expression by UniProt/SwissProt for SH3BGRL2 Gene

Tissue specificity: Highly expressed in brain, placenta, liver and kidney. Expressed in retina.
genes like me logo Genes that share expressions with SH3BGRL2: view

No data available for mRNA differential expression in normal tissues for SH3BGRL2 Gene

Orthologs for SH3BGRL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3BGRL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SH3BGRL2 35
  • 99.69 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia SH3BGRL2 35
  • 92.45 (n)
  • 93.4 (a)
  • 80 (a)
(Canis familiaris)
Mammalia LOC474977 35
  • 94.39 (n)
  • 94.39 (a)
  • 93 (a)
(Mus musculus)
Mammalia Sh3bgrl2 35
  • 88.47 (n)
  • 93.46 (a)
Sh3bgrl2 16
Sh3bgrl2 36
  • 93 (a)
(Monodelphis domestica)
Mammalia SH3BGRL2 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia SH3BGRL2 36
  • 77 (a)
(Rattus norvegicus)
Mammalia LOC102554622 35
  • 87.85 (n)
  • 93.46 (a)
(Gallus gallus)
Aves SH3BGRL2 35
  • 80.77 (n)
  • 85.58 (a)
  • 67 (a)
(Anolis carolinensis)
Reptilia SH3BGRL2 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3bgrl2 35
  • 72.44 (n)
  • 73.08 (a)
Str.10801 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1778 35
(Danio rerio)
Actinopterygii sh3bgrl2 35
  • 68.73 (n)
  • 73.2 (a)
sh3bgrl2 36
  • 70 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sh3beta 36
  • 8 (a)
(Caenorhabditis elegans)
Secernentea Y105E8A.1 36
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
Species with no ortholog for SH3BGRL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3BGRL2 Gene

Gene Tree for SH3BGRL2 (if available)
Gene Tree for SH3BGRL2 (if available)

Paralogs for SH3BGRL2 Gene

Paralogs for SH3BGRL2 Gene

Selected SIMAP similar genes for SH3BGRL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SH3BGRL2: view

Variants for SH3BGRL2 Gene

Sequence variations from dbSNP and Humsavar for SH3BGRL2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1507 -- 79,701,855(+) AGCTG(A/C)CTTTA utr-variant-3-prime
rs8869 -- 79,703,520(-) TTCAG(C/G)AAACC utr-variant-3-prime
rs718943 -- 79,656,079(-) TAAAT(C/T)AGATG intron-variant
rs718944 -- 79,655,960(-) CAACT(A/C)CCTTC intron-variant
rs718945 -- 79,655,928(-) TGGCT(C/T)TCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH3BGRL2 Gene

Variant ID Type Subtype PubMed ID
dgv6930n71 CNV Gain 21882294
nsv886304 CNV Gain 21882294
nsv5368 CNV Insertion 18451855
dgv1139e199 CNV Deletion 23128226

Relevant External Links for SH3BGRL2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3BGRL2 Gene

Disorders for SH3BGRL2 Gene

Relevant External Links for SH3BGRL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SH3BGRL2: view

No data available for UniProtKB/Swiss-Prot for SH3BGRL2 Gene

Publications for SH3BGRL2 Gene

  1. The identification of a novel human homologue of the SH3 binding glutamic acid-rich (SH3BGR) gene establishes a new family of highly conserved small proteins related to Thioredoxin Superfamily. (PMID: 12095696) Mazzocco M. … Scartezzini P. (Gene 2002) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study. (PMID: 20522523) KasperaviciAte D. … Sisodiya S.M. (Brain 2010) 3 48
  4. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PMID: 21565611) Sang L. … Jackson P.K. (Cell 2011) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for SH3BGRL2 Gene

Sources for SH3BGRL2 Gene

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