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SH3BGRL Gene

protein-coding   GIFtS: 58
GCID: GC0XP080457

SH3 Domain Binding Glutamate-Rich Protein Like

(Previous name: SH3 domain binding glutamic acid-rich protein like)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SH3 Domain Binding Glutamate-Rich Protein Like1 2     Epididymis Secretory Protein Li 1152
SH3 Domain Binding Glutamic Acid-Rich Protein Like1 2     SH3 Domain-Binding Glutamic Acid-Rich-Like Protein2
SH3BGR2 5     SH3-Binding Domain Glutamic Acid-Rich Protein Like2
HEL-S-1152     

External Ids:    HGNC: 108231   Entrez Gene: 64512   Ensembl: ENSG000001311717   OMIM: 3001905   UniProtKB: O753683   

Export aliases for SH3BGRL gene to outside databases

Previous GC identifers: GC0XP076003 GC0XP077419 GC0XP078498 GC0XP079213 GC0XP080263 GC0XP074037


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SH3BGRL Gene:
SH3BGRL (SH3 domain binding glutamate-rich protein like) is a protein-coding gene. Diseases associated with SH3BGRL include endocarditis, and down syndrome. GO annotations related to this gene include SH3/SH2 adaptor activity and SH3 domain binding. An important paralog of this gene is SH3BGRL2.

Gene Wiki entry for SH3BGRL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the SH3BGRL gene promoter:
         HOXA9B   HOXA9   RP58   C/EBPbeta   FOXO3   FOXO3b   Meis-1b   FOXO3a   RSRFC4   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSH3BGRL promoter sequence
   Search Chromatin IP Primers for SH3BGRL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SH3BGRL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.3   Ensembl cytogenetic band:  Xq21.1   HGNC cytogenetic band: Xq13.3

SH3BGRL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SH3BGRL gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP080457:  view genomic region     (about GC identifiers)

Start:
80,457,303 bp from pter      End:
80,554,046 bp from pter
Size:
96,744 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SH3L1_HUMAN, O75368 (See protein sequence)
Recommended Name: SH3 domain-binding glutamic acid-rich-like protein  
Size: 114 amino acids; 12774 Da
2 PDB 3D structures from and Proteopedia for SH3BGRL:
1U6T (3D)        1WRY (3D)    
Secondary accessions: Q3SYL1 Q5JT50 Q6FIE8 Q9H0N8

Explore the universe of human proteins at neXtProt for SH3BGRL: NX_O75368

Explore proteomics data for SH3BGRL at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys111

  • See SH3BGRL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003013.1  
    ENSEMBL proteins: 
     ENSP00000362308  

    SH3BGRL Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for SH3BGRL

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR006993 Glut_rich_SH3-bd
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry O75368

    ProtoNet protein and cluster: O75368

    1 Blocks protein domain: IPB006993 SH3-binding

    UniProtKB/Swiss-Prot: SH3L1_HUMAN, O75368
    Similarity: Belongs to the SH3BGR family


    SH3BGRL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for SH3BGRL:
    SH3 domain binding,glutamic acid protein-like,widely expressed

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity TAS9642120
    GO:0017124SH3 domain binding IEA--
         
    SH3BGRL for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SH3BGRL
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SH3BGRL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SH3BGRL

    miRNA
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    miRTarBase miRNAs that target SH3BGRL:
    hsa-mir-181a-5p (MIRT025132), hsa-mir-132-3p (MIRT021777), hsa-mir-128-3p (MIRT022023)

    Block miRNA regulation of human, mouse, rat SH3BGRL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SH3BGRL (see all 16):
    hsa-miR-548j hsa-miR-548w hsa-miR-3163 hsa-miR-559 hsa-miR-548i hsa-miR-548h hsa-miR-548c-5p hsa-miR-548y
    SwitchGear 3'UTR luciferase reporter plasmidSH3BGRL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SH3BGRL
    Predesigned siRNA for gene silencing in human, mouse, rat SH3BGRL

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SH3BGRL (NM_003022)
    Sino Biological Human cDNA Clone for SH3BGRL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SH3BGRL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH3BGRL

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    Browse ESI BIO Cell Lines and PureStem Progenitors for SH3BGRL 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3BGRL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion3
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005634nucleus TAS16130169
    GO:0005737cytoplasm TAS16130169
    GO:0070062extracellular vesicular exosome IDA19056867

    SH3BGRL for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SH3BGRL About                                                                                                See pathways by source

    SuperPathContained pathways About
    1EGFR1 Signaling Pathway
    EGFR1 Signaling Pathway


    1 BioSystems Pathway for SH3BGRL
        EGFR1 Signaling Pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SH3BGRL
    Interactions:

        Search GeneGlobe Interaction Network for SH3BGRL

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for SH3BGRL (O753682, 3 ENSP000003623084) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EGFRP005332, 3, ENSP000002754934MINT-61483 I2D: score=3 STRING: ENSP00000275493
    ATG5Q9H1Y03I2D: score=1 
    ERBB2P046263I2D: score=1 
    IL7RP168713I2D: score=1 
    EIF1AXENSP000003689274STRING: ENSP00000368927
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009967positive regulation of signal transduction TAS9642120

    SH3BGRL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SH3BGRL (SH3L1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SH3BGRL gene: 
    NM_003022.2  

    Unigene Cluster for SH3BGRL:

    SH3 domain binding glutamic acid-rich protein like
    Hs.108029  [show with all ESTs]
    Unigene Representative Sequence: NM_003022
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373212(uc004eef.3 uc011mqs.2 uc010nml.3 uc010nmm.3 uc010nmn.3)
    ENST00000481106 ENST00000463546 ENST00000474113
    miRNA
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    Block miRNA regulation of human, mouse, rat SH3BGRL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SH3BGRL (see all 16):
    hsa-miR-548j hsa-miR-548w hsa-miR-3163 hsa-miR-559 hsa-miR-548i hsa-miR-548h hsa-miR-548c-5p hsa-miR-548y
    SwitchGear 3'UTR luciferase reporter plasmidSH3BGRL 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SH3BGRL
    Predesigned siRNA for gene silencing in human, mouse, rat SH3BGRL
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    OriGene clones in human, mouse for SH3BGRL (see all 6)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SH3BGRL (NM_003022)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SH3BGRL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH3BGRL
    Primer
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    OriGene qPCR primer pairs and template standards for SH3BGRL
    OriGene qSTAR qPCR primer pairs in human, mouse for SH3BGRL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SH3BGRL
      QuantiTect SYBR Green Assays in human, mouse, rat SH3BGRL
      QuantiFast Probe-based Assays in human, mouse, rat SH3BGRL

    Additional mRNA sequence: 

    AF042081.1 AK024892.1 AK129610.1 AK309350.1 AK309351.1 AK309352.1 AK310011.1 AK310155.1 
    AK315897.1 AL136718.1 BC016709.1 BC103762.1 CR533478.1 

    22 DOTS entries:

    DT.80101740  DT.101981144  DT.100845614  DT.100845613  DT.121321260  DT.100845612  DT.99956343  DT.100845611 
    DT.87017199  DT.100845628  DT.95117451  DT.121321192  DT.121321250  DT.91770810  DT.100701582  DT.100845608 
    DT.121321196  DT.121321203  DT.121321282  DT.121321290  DT.91770798  DT.99979017 

    Selected AceView cDNA sequences (see all 564):

    BP337585 CD365867 CR590536 AI378298 AI439873 BM693049 BP376291 BP334476 
    AI185768 AA034026 BE122714 AI589471 BP367156 BG504234 BM760632 BE049550 
    AW009262 BM843968 BE677214 BP362319 BM761749 CB215361 BP377253 AI784486 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SH3BGRL (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e
    SP1:                          -     -     -     -                             -                                 
    SP2:                                      -     -     -                       -                                 
    SP3:                          -     -     -     -     -                       -                                 
    SP4:                                                  -                       -                                 
    SP5:                          -     -     -     -     -           -           -                                 


    ECgene alternative splicing isoforms for SH3BGRL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SH3BGRL expression in normal human tissues (normalized intensities)      SH3BGRL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGATTCAAAC
    SH3BGRL Expression
    About this image


    SH3BGRL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Mesonephric cells Mesonephros
             Mesonephros
     
     Gonad
             Primordial Germ Cells Primitive Gonad
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     Kidney (Urinary System)
             Metanephros
     
     Neural Tube (Nervous System)
             Telencephalon
    SH3BGRL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SH3BGRL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.108029

    UniProtKB/Swiss-Prot: SH3L1_HUMAN, O75368
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for SH3BGRL
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    QuantiTect SYBR Green Assays in human, mouse, rat SH3BGRL
    QuantiFast Probe-based Assays in human, mouse, rat SH3BGRL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3BGRL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SH3BGRL gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sh3bgrl1 , 5 SH3-binding domain glutamic acid-rich protein like1, 5 92.69(n)1
    94.74(a)1
      X (47.92 cM)5
    567261  NM_019989.21  NP_064373.11 
     1090953655 
    chicken
    (Gallus gallus)
    Aves SH3BGRL1 SH3 domain binding glutamic acid-rich protein like 80.12(n)
    86.84(a)
      422277  NM_001012574.1  NP_001012592.1 
    lizard
    (Anolis carolinensis)
    Reptilia SH3BGRL6
    SH3 domain binding glutamic acid-rich protein like...
    85(a)
    1 ↔ 1
    GL343202.1(20006-51358)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sh3bgrl1 SH3 domain binding glutamic acid-rich protein like 78.95(n)
    84.21(a)
      101733396  XM_004916893.1  XP_004916950.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc641302 similar to SH3 domain binding glutamic acid-rich protein more 75.05(n)   394184  BC054623.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sh3beta6
    Sh3beta
    9(a)
    1 → many
    3L(7357684-7362360)
    worm
    (Caenorhabditis elegans)
    Secernentea Y105E8A.16
    Protein Y105E8A.1, isoform b
    18(a)
    1 → many
    I(14341520-14343805) WBGene00013666


    ENSEMBL Gene Tree for SH3BGRL (if available)
    TreeFam Gene Tree for SH3BGRL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SH3BGRL gene
    SH3BGRL22  SH3BGR2  SH3BGRL32  
    4 SIMAP similar genes for SH3BGRL using alignment to 2 protein entries:     SH3L1_HUMAN (see all proteins):
    SH3BGRL2    SH3BGR    HEL-S-297    SH3BGRL3

    SH3BGRL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SH3BGRL (see all 1258)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1857407521,2
    --80459614(+) GCAAAG/TGGCAG 1 -- int10--------
    rs1893787671,2
    --80459657(+) TTTGTC/TATGAG 1 -- int10--------
    rs1809913391,2
    --80459717(+) TGAACC/TTGTTA 1 -- int10--------
    rs1853696941,2
    --80459973(+) ATTGCA/GCATAG 1 -- int10--------
    rs736347241,2
    C,F--80460070(+) TCTTAG/ATCTTC 1 -- int11Minor allele frequency- A:0.00WA 2
    rs1881074461,2
    --80460292(+) ATCCAG/TCCTGG 1 -- int10--------
    rs1813162741,2
    --80460294(+) CCAGCC/TTGGGC 1 -- int10--------
    rs1864951281,2
    --80460368(+) TAGCAC/TTTGCT 1 -- int10--------
    rs120119431,2
    C,F,H--80460470(+) tatggG/Aggaca 1 -- int15Minor allele frequency- A:0.02NS EA WA 420
    rs284778221,2
    C,F--80460583(+) CCAAAT/CATTCT 1 -- int11Minor allele frequency- C:0.00CSA 1

    HapMap Linkage Disequilibrium report for SH3BGRL (80457303 - 80554046 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SH3BGRL:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674896CNV Deletion23128226
    nsv6973CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SH3BGRL
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300190    OMIM disorders: --

    4 diseases for SH3BGRL:    About MalaCards
    endocarditis    down syndrome    obesity    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for SH3BGRL:
    Down syndrome

    SH3BGRL for disorders           About GeneDecksing

    Genetic Association Database (GAD): SH3BGRL
    Human Genome Epidemiology (HuGE) Navigator: SH3BGRL (1 document)

    Export disorders for SH3BGRL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SH3BGRL gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with SH3BGRL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a new human gene encoding a small protein with high homology to the proline-rich region of the SH3BGR gene. (PubMed id 9642120)1, 2, 3, 9 Egeo A.... Scartezzini P. (Biochem. Biophys. Res. Commun. 1998)
    2. Use of genome-wide expression data to mine the &quot;Gray Zone&quot; of GWA studies leads to novel candidate obesity genes. (PubMed id 20532202)1, 4 Naukkarinen J....Peltonen L. (PLoS Genet. 2010)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    4. Crystal structure of human SH3BGRL protein: the first structure of the human SH3BGR family representing a novel class of thioredoxin fold proteins. (PubMed id 16080146)1, 2 Yin L.... Wang D.C. (Proteins 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6451 HGNC: 10823 AceView: SH3BGRL Ensembl:ENSG00000131171 euGenes: HUgn6451
    ECgene: SH3BGRL H-InvDB: SH3BGRL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SH3BGRL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SH3BGRL gene:
    Search GeneIP for patents involving SH3BGRL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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