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Aliases for SH3BGRL Gene

Aliases for SH3BGRL Gene

  • SH3 Domain Binding Glutamate Rich Protein Like 2 3
  • SH3 Domain Binding Glutamic Acid-Rich Protein Like 2 3
  • SH3 Domain Binding Glutamate-Rich Protein Like 3 5
  • SH3-Binding Domain Glutamic Acid-Rich Protein Like 3
  • Epididymis Secretory Protein Li 115 3
  • HEL-S-115 3
  • SH3BGR 3

External Ids for SH3BGRL Gene

Previous GeneCards Identifiers for SH3BGRL Gene

  • GC0XP076003
  • GC0XP077419
  • GC0XP078498
  • GC0XP079213
  • GC0XP080263
  • GC0XP080457
  • GC0XP074037

Summaries for SH3BGRL Gene

GeneCards Summary for SH3BGRL Gene

SH3BGRL (SH3 Domain Binding Glutamate Rich Protein Like) is a Protein Coding gene. Among its related pathways are EGFR1 Signaling Pathway. GO annotations related to this gene include SH3 domain binding and SH3/SH2 adaptor activity. An important paralog of this gene is SH3BGRL3.

Gene Wiki entry for SH3BGRL Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3BGRL Gene

Genomics for SH3BGRL Gene

Regulatory Elements for SH3BGRL Gene

Promoters for SH3BGRL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SH3BGRL on UCSC Golden Path with GeneCards custom track

Genomic Location for SH3BGRL Gene

Chromosome:
X
Start:
81,201,804 bp from pter
End:
81,298,547 bp from pter
Size:
96,744 bases
Orientation:
Plus strand

Genomic View for SH3BGRL Gene

Genes around SH3BGRL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3BGRL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3BGRL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3BGRL Gene

Proteins for SH3BGRL Gene

  • Protein details for SH3BGRL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75368-SH3L1_HUMAN
    Recommended name:
    SH3 domain-binding glutamic acid-rich-like protein
    Protein Accession:
    O75368
    Secondary Accessions:
    • Q3SYL1
    • Q5JT50
    • Q6FIE8
    • Q9H0N8

    Protein attributes for SH3BGRL Gene

    Size:
    114 amino acids
    Molecular mass:
    12774 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SH3BGRL Gene

neXtProt entry for SH3BGRL Gene

Proteomics data for SH3BGRL Gene at MOPED

Post-translational modifications for SH3BGRL Gene

  • Ubiquitination at Lys 111
  • Modification sites at PhosphoSitePlus

Other Protein References for SH3BGRL Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SH3BGRL Gene

Domains & Families for SH3BGRL Gene

Protein Domains for SH3BGRL Gene

Suggested Antigen Peptide Sequences for SH3BGRL Gene

Graphical View of Domain Structure for InterPro Entry

O75368

UniProtKB/Swiss-Prot:

SH3L1_HUMAN :
  • Belongs to the SH3BGR family.
Family:
  • Belongs to the SH3BGR family.
genes like me logo Genes that share domains with SH3BGRL: view

No data available for Gene Families for SH3BGRL Gene

Function for SH3BGRL Gene

Molecular function for SH3BGRL Gene

GENATLAS Biochemistry:
SH3 domain binding,glutamic acid protein-like,widely expressed

Gene Ontology (GO) - Molecular Function for SH3BGRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with SH3BGRL: view

Phenotypes for SH3BGRL Gene

GenomeRNAi human phenotypes for SH3BGRL:
genes like me logo Genes that share phenotypes with SH3BGRL: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH3BGRL Gene

Localization for SH3BGRL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SH3BGRL Gene COMPARTMENTS Subcellular localization image for SH3BGRL gene
Compartment Confidence
extracellular 5
nucleus 5
mitochondrion 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SH3BGRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005737 cytoplasm TAS 16130169
genes like me logo Genes that share ontologies with SH3BGRL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SH3BGRL Gene

Pathways & Interactions for SH3BGRL Gene

SuperPathways for SH3BGRL Gene

Superpath Contained pathways
1 EGFR1 Signaling Pathway
genes like me logo Genes that share pathways with SH3BGRL: view

Pathways by source for SH3BGRL Gene

1 BioSystems pathway for SH3BGRL Gene

Gene Ontology (GO) - Biological Process for SH3BGRL Gene

None

No data available for SIGNOR curated interactions for SH3BGRL Gene

Drugs & Compounds for SH3BGRL Gene

No Compound Related Data Available

Transcripts for SH3BGRL Gene

Unigene Clusters for SH3BGRL Gene

SH3 domain binding glutamic acid-rich protein like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SH3BGRL Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - -
SP5: - - - - - - -
SP6: -
SP7: - - - - -

Relevant External Links for SH3BGRL Gene

GeneLoc Exon Structure for
SH3BGRL
ECgene alternative splicing isoforms for
SH3BGRL

Expression for SH3BGRL Gene

mRNA expression in normal human tissues for SH3BGRL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SH3BGRL Gene



SOURCE GeneReport for Unigene cluster for SH3BGRL Gene Hs.108029

mRNA Expression by UniProt/SwissProt for SH3BGRL Gene

O75368-SH3L1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with SH3BGRL: view

Protein tissue co-expression partners for SH3BGRL Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for SH3BGRL Gene

Orthologs for SH3BGRL Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3BGRL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SH3BGRL 35
  • 94.15 (n)
  • 98.25 (a)
SH3BGRL 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SH3BGRL 35
  • 93.57 (n)
  • 98.25 (a)
SH3BGRL 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sh3bgrl 35
  • 92.69 (n)
  • 94.74 (a)
Sh3bgrl 16
Sh3bgrl 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SH3BGRL 35
  • 99.71 (n)
  • 100 (a)
SH3BGRL 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sh3bgrl 35
  • 92.98 (n)
  • 95.61 (a)
oppossum
(Monodelphis domestica)
Mammalia SH3BGRL 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SH3BGRL 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves SH3BGRL 35
  • 80.12 (n)
  • 86.84 (a)
SH3BGRL 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SH3BGRL 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3bgrl 35
  • 78.95 (n)
  • 84.21 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc64130 35
zgc:64130 35
  • 72.02 (n)
  • 79.46 (a)
SH3BGRL 36
  • 77 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8940 35
fruit fly
(Drosophila melanogaster)
Insecta Sh3beta 36
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y105E8A.1 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for SH3BGRL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3BGRL Gene

ENSEMBL:
Gene Tree for SH3BGRL (if available)
TreeFam:
Gene Tree for SH3BGRL (if available)

Paralogs for SH3BGRL Gene

Paralogs for SH3BGRL Gene

(4) SIMAP similar genes for SH3BGRL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SH3BGRL: view

Variants for SH3BGRL Gene

Sequence variations from dbSNP and Humsavar for SH3BGRL Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs9675 -- 81,278,345(+) GCCTT(C/T)TTTGA reference, synonymous-codon
rs1120430 -- 81,288,127(-) TTGAA(C/T)GATCA intron-variant
rs1290504 -- 81,286,528(-) TCCCC(C/T)CTCtt intron-variant
rs1137387 -- 81,290,835(+) TACCC(A/C)ATAAA intron-variant
rs1044828 -- 81,297,730(+) ATTTC(C/T)TATCG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SH3BGRL Gene

Variant ID Type Subtype PubMed ID
esv2674896 CNV Deletion 23128226
nsv6973 CNV Insertion 18451855

Variation tolerance for SH3BGRL Gene

Residual Variation Intolerance Score: 46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH3BGRL Gene

HapMap Linkage Disequilibrium report
SH3BGRL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3BGRL Gene

Disorders for SH3BGRL Gene

Relevant External Links for SH3BGRL

Genetic Association Database (GAD)
SH3BGRL
Human Genome Epidemiology (HuGE) Navigator
SH3BGRL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SH3BGRL

No disorders were found for SH3BGRL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3BGRL Gene

Publications for SH3BGRL Gene

  1. Identification and characterization of a new human gene encoding a small protein with high homology to the proline-rich region of the SH3BGR gene. (PMID: 9642120) Egeo A. … Scartezzini P. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naA^ve to therapy. (PMID: 23580065) Pieragostino D. … Del Boccio P. (Mol Biosyst 2013) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for SH3BGRL Gene

Sources for SH3BGRL Gene

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