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Aliases for SH3BGRL Gene

Aliases for SH3BGRL Gene

  • SH3 Domain Binding Glutamate-Rich Protein Like 2 3
  • SH3 Domain Binding Glutamic Acid-Rich Protein Like 2 3
  • SH3BGR 3 6
  • SH3 Domain-Binding Glutamic Acid-Rich-Like Protein 3
  • SH3-Binding Domain Glutamic Acid-Rich Protein Like 3
  • Epididymis Secretory Protein Li 115 3
  • HEL-S-115 3

External Ids for SH3BGRL Gene

Previous GeneCards Identifiers for SH3BGRL Gene

  • GC0XP076003
  • GC0XP077419
  • GC0XP078498
  • GC0XP079213
  • GC0XP080263
  • GC0XP080457
  • GC0XP074037

Summaries for SH3BGRL Gene

GeneCards Summary for SH3BGRL Gene

SH3BGRL (SH3 Domain Binding Glutamate-Rich Protein Like) is a Protein Coding gene. Among its related pathways are EGFR1 Signaling Pathway. GO annotations related to this gene include SH3 domain binding and SH3/SH2 adaptor activity. An important paralog of this gene is SH3BGRL3.

Gene Wiki entry for SH3BGRL Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3BGRL Gene

Genomics for SH3BGRL Gene

Regulatory Elements for SH3BGRL Gene

Genomic Location for SH3BGRL Gene

81,201,804 bp from pter
81,298,547 bp from pter
96,744 bases
Plus strand

Genomic View for SH3BGRL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SH3BGRL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3BGRL Gene

Proteins for SH3BGRL Gene

  • Protein details for SH3BGRL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH3 domain-binding glutamic acid-rich-like protein
    Protein Accession:
    Secondary Accessions:
    • Q3SYL1
    • Q5JT50
    • Q6FIE8
    • Q9H0N8

    Protein attributes for SH3BGRL Gene

    114 amino acids
    Molecular mass:
    12774 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SH3BGRL Gene

neXtProt entry for SH3BGRL Gene

Proteomics data for SH3BGRL Gene at MOPED

Post-translational modifications for SH3BGRL Gene

  • Ubiquitination at Lys111
  • Modification sites at PhosphoSitePlus

Other Protein References for SH3BGRL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SH3BGRL Gene

Domains for SH3BGRL Gene

Protein Domains for SH3BGRL Gene

Suggested Antigen Peptide Sequences for SH3BGRL Gene

Graphical View of Domain Structure for InterPro Entry



  • O75368
  • Belongs to the SH3BGR family.
genes like me logo Genes that share domains with SH3BGRL: view

No data available for Gene Families for SH3BGRL Gene

Function for SH3BGRL Gene

Molecular function for SH3BGRL Gene

GENATLAS Biochemistry: SH3 domain binding,glutamic acid protein-like,widely expressed

Gene Ontology (GO) - Molecular Function for SH3BGRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 9642120
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with SH3BGRL: view

Animal Model Products

CRISPR Products

miRNA for SH3BGRL Gene

miRTarBase miRNAs that target SH3BGRL

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SH3BGRL Gene

Localization for SH3BGRL Gene

Subcellular locations from

Jensen Localization Image for SH3BGRL Gene COMPARTMENTS Subcellular localization image for SH3BGRL gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SH3BGRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005634 nucleus TAS 16130169
GO:0005737 cytoplasm TAS 16130169
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SH3BGRL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SH3BGRL Gene

Pathways for SH3BGRL Gene

SuperPathways for SH3BGRL Gene

Superpath Contained pathways
1 EGFR1 Signaling Pathway
genes like me logo Genes that share pathways with SH3BGRL: view

Pathways by source for SH3BGRL Gene

1 BioSystems pathway for SH3BGRL Gene

Interacting Proteins for SH3BGRL Gene

Gene Ontology (GO) - Biological Process for SH3BGRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009967 positive regulation of signal transduction TAS 9642120
genes like me logo Genes that share ontologies with SH3BGRL: view

Transcripts for SH3BGRL Gene

Unigene Clusters for SH3BGRL Gene

SH3 domain binding glutamic acid-rich protein like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SH3BGRL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3BGRL Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - -
SP5: - - - - - - -
SP6: -
SP7: - - - - -

Relevant External Links for SH3BGRL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH3BGRL Gene

mRNA expression in normal human tissues for SH3BGRL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SH3BGRL Gene

SOURCE GeneReport for Unigene cluster for SH3BGRL Gene Hs.108029

mRNA Expression by UniProt/SwissProt for SH3BGRL Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with SH3BGRL: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SH3BGRL Gene

Orthologs for SH3BGRL Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3BGRL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SH3BGRL 35
  • 99.71 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia SH3BGRL 35
  • 94.15 (n)
  • 98.25 (a)
  • 98 (a)
(Canis familiaris)
Mammalia SH3BGRL 35
  • 93.57 (n)
  • 98.25 (a)
  • 87 (a)
(Mus musculus)
Mammalia Sh3bgrl 35
  • 92.69 (n)
  • 94.74 (a)
Sh3bgrl 16
Sh3bgrl 36
  • 95 (a)
(Monodelphis domestica)
Mammalia SH3BGRL 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia SH3BGRL 36
  • 91 (a)
(Rattus norvegicus)
Mammalia Sh3bgrl 35
  • 92.98 (n)
  • 95.61 (a)
(Gallus gallus)
Aves SH3BGRL 35
  • 80.12 (n)
  • 86.84 (a)
  • 79 (a)
(Anolis carolinensis)
Reptilia SH3BGRL 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3bgrl 35
  • 78.95 (n)
  • 84.21 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8940 35
(Danio rerio)
Actinopterygii SH3BGRL 36
  • 77 (a)
zgc64130 35
zgc:64130 35
  • 72.02 (n)
  • 79.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sh3beta 36
  • 9 (a)
(Caenorhabditis elegans)
Secernentea Y105E8A.1 36
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
Species with no ortholog for SH3BGRL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3BGRL Gene

Gene Tree for SH3BGRL (if available)
Gene Tree for SH3BGRL (if available)

Paralogs for SH3BGRL Gene

Paralogs for SH3BGRL Gene

Selected SIMAP similar genes for SH3BGRL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SH3BGRL: view

Variants for SH3BGRL Gene

Sequence variations from dbSNP and Humsavar for SH3BGRL Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs9675 -- 81,278,345(+) GCCTT(C/T)TTTGA reference, synonymous-codon
rs1044828 -- 81,297,730(+) ATTTC(C/T)TATCG utr-variant-3-prime
rs1044830 -- 81,297,925(+) GGAAT(C/G)ATATA utr-variant-3-prime
rs1120430 -- 81,288,127(-) TTGAA(C/T)GATCA intron-variant
rs1137387 -- 81,290,835(+) TACCC(A/C)ATAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH3BGRL Gene

Variant ID Type Subtype PubMed ID
esv2674896 CNV Deletion 23128226
nsv6973 CNV Insertion 18451855

Relevant External Links for SH3BGRL Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3BGRL Gene

Disorders for SH3BGRL Gene

(1) University of Copenhagen DISEASES for SH3BGRL Gene

Relevant External Links for SH3BGRL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SH3BGRL: view

No data available for UniProtKB/Swiss-Prot for SH3BGRL Gene

Publications for SH3BGRL Gene

  1. Identification and characterization of a new human gene encoding a small protein with high homology to the proline-rich region of the SH3BGR gene. (PMID: 9642120) Egeo A. … Scartezzini P. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23
  2. Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PMID: 20532202) Naukkarinen J. … Peltonen L. (PLoS Genet. 2010) 3 48
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  5. Crystal structure of human SH3BGRL protein: the first structure of the human SH3BGR family representing a novel class of thioredoxin fold proteins. (PMID: 16080146) Yin L. … Wang D.C. (Proteins 2005) 3 4

Products for SH3BGRL Gene

Sources for SH3BGRL Gene

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