SH3BGR Gene
protein-coding GIFtS : 55
GCID: GC21 P040817
SH3 domain binding glutamic acid-rich protein
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Aliasesfor SH3BGR gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb , and/or 11 Nature :405,311-319 and CroW21)About This Section Aliases SH3 Domain Binding Glutamic Acid-Rich Protein 1 2 SH3 Domain-Binding Glutamic Acid-Rich Protein2 21-GARP1 2 3 SH3-Binding Domain And Glutamic Acid-Rich Protein2 21-Glutamic Acid-Rich Protein2 3 SH3BGR Protein3 21-Glutamic Acid-Rich Protein (21-GARP)11 SH3GBR5
Export aliases for SH3BGR gene to outside databases Previous GC identifers: GC21P037398 GC21P039738 GC21P039744 GC21P039745 GC21P026286
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Summariesfor SH3BGR gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Gene Wiki entry for SH3BGR
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Genomic Viewsfor SH3BGR gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics , Whole Chromsome Sequence According to
Nature (Cited Here with Permission) :405,311-319 and CroW21)About This Section
GC21P040817:
GeneLoc
Nature :405,311-319
Start:
40,817,781 bp from pter
26,397,539 bp from centromere
End:
40,887,433 bp from pter
26,461,157 bp from centromere
Size:
69,653 bases
63,619 bases
Orientation:
plus strand
plus strand
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Proteinsfor SH3BGR gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SH3BG_HUMAN, P55822 (See
protein sequence )Recommended Name: SH3 domain-binding glutamic acid-rich protein Size : 239 amino acids; 26086 Da
Caution : It is uncertain whether Met-1 or Met-64 is the initiator
Secondary accessions : A6ND59 D3DSI2 Q9BRB8Alternative splicing : 2 isoforms : P55822-1 P55822-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SH3BGR: NX_P55822 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P55822 SH3BGR Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001001713.1 NP_031367.1 ENSEMBL proteins: ENSP00000370011 ENSP00000370008 ENSP00000404980 ENSP00000401572 ENSP00000370005 ENSP00000332513 ENSP00000405675 ENSP00000413981 ENSP00000403115 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
SH3BGR for ontologies About GeneDecksing SH3BGR Antibody Products: Assay Products for SH3BGR:
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Protein
Domains / Familiesfor SH3BGR gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SH3BGR for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P55822 ProtoNet protein and cluster: P55822
1 Blocks protein family : IPB006993 SH3-binding UniProtKB/Swiss-Prot: SH3BG_HUMAN, P55822 Similarity : Belongs to the SH3BGR family
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Functionfor SH3BGR gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: Genatlas biochemistry entry for SH3BGR : SH3 domain binding,glutamic acid rich protein,expressed only in heart and skeletal muscle Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SH3BGR (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SH3BGR (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): SH3BGR (NM_007341 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SH3BGR Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SH3BGR
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3BGR
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
SH3BGR for ontologies About GeneDecksing
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Pathways & Interactionsfor SH3BGR gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SH3BGR STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)3 Interacting proteins for SH3BGR (P55822 3 ENSP00000332513 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006461 protein complex assembly
TAS 9050928
SH3BGR for ontologies About GeneDecksing
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Drugs & Compoundsfor SH3BGR gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SH3BGR Search CenterWatch for drugs/clinical trials and news about SH3BGR / SH3BG
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Transcriptsfor SH3BGR gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SH3BGR gene (2 alternative transcripts): NM_001001713.1 NM_007341.2 Unigene Cluster for SH3BGR:
SH3 domain binding glutamic acid-rich protein Hs.473847 [show with all ESTs ] Unigene Representative Sequence: NM_007341 9 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000380637 (uc002yxz.3 ) ENST00000380634 ENST00000458295 ENST00000440288 ENST00000380631 ENST00000333634 (uc002yya.3 ) ENST00000452550 ENST00000423596 ENST00000447939 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SH3BGR (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SH3BGR (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): SH3BGR (NM_007341 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SH3BGR Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SH3BGR
Additional cDNA sequence: BC006371.2 BT006994.1 X93498.1
8 DOTS entries : DT.102834035 DT.311166
DT.121139415 DT.95268325 DT.97841175 DT.121139456 DT.121139386 DT.91895956 24/393 AceView cDNA sequences (see all 393 ):
BQ574343 BG742101 BM703010 AU142922 CA419722 BP368925 NM_001001713 AI074642 CB114295 AA099383 BE645493 CB113614 BM128577 BP372637 BM669961 CK819351 AA247739 BM698634 BM128409 BM470417 BE673753 BU734633 AV653124 BQ771788 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for SH3BGR About this scheme ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 SP1 :                   SP2 :           -         SP3 :                  
ECgene alternative splicing isoforms for SH3BGR
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Expression for SH3BGR gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SH3BGR expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GAAGTTCTCT
About this image SH3BGR expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See SH3BGR Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SH3BGR SOURCE GeneReport for Unigene cluster: Hs.473847 UniProtKB/Swiss-Prot: SH3BG_HUMAN, P55822 Tissue specificity : Expressed in heart and skeletal muscle SABiosciences Custom PCR Arrays for SH3BGR Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SH3BGRBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat SH3BGR QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SH3BGR QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SH3BGR In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3BGR
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Orthologsfor SH3BGR gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for SH3BGR gene from 6/18 species (see all 18 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
SH3BGR1
SH3 domain binding glutamic acid-rich protein
73.81(n) 72.62(a)
 
418523 XM_416732.3 XP_416732.1
lizard (Anolis carolinensis)
Reptilia
SH3BGR6
--
51(a)
1 ↔ 1
3(139609020-139638433)
African clawed frog (Xenopus laevis)
Amphibia
Xl.245372
Xenopus laevis transcribed sequence with moderate similarity more
76.09(n)
 
BJ058013.1
zebrafish (Danio rerio)
Actinopterygii
Dr.134872
Transcribed sequence with weak similarity to protein more
73.83(n)
 
BI865553.1
fruit fly (Drosophila melanogaster)
Insecta
Sh3beta1
CG8582-PA
49.6(n) 38.1(a)
 
38820 NM_001202128.1 NP_001189057.1
worm (Caenorhabditis elegans)
Secernentea
Y105E8A.16
--
28(a)
1 → many
I(14341621-14343793)
ENSEMBL Gene Tree for SH3BGR (if available)TreeFam Gene Tree for SH3BGR (if available)
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Paralogsfor SH3BGR gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SH3BGR gene SH3BGRL2 2 SH3BGRL 2 SH3BGRL3 2 3 SIMAP similar genes for SH3BGR using alignment to 6 protein entries: SH3BG_HUMAN (see all proteins ):SH3BGRL SH3BGRL2 SH3BGRL3
SH3BGR for paralogs About GeneDecksing
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Genomic Variantsfor SH3BGR gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 21 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for SH3BGR (40817781 - 40887433 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for SH3BGR 2 CNVs : 3233 8896
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SH3BGR
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Disorders
/ Diseasesfor SH3BGR gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
SH3BGR for disorders About GeneDecksing
OMIM gene information: 602230
OMIM disorders : --4 diseases for SH3BGR : About MalaCards down syndrome obesity pancreatic cancer pancreatitis 1 disease from the University of Copenhagen DISEASES database for SH3BGR :Down syndrome Human Genome Epidemiology (HuGE) Navigator: SH3BGR (1 document)Export disorders for SH3BGR gene to outside databases
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Publicationsfor SH3BGR gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SH3BGR gene integrated from 9 sources : (articles sorted by number of sources associating them with SH3BGR) Utopia : connect your pdf to the dynamic world of online information
Cloning a new human gene from chromosome 21q22.3 encoding a glutamic acid-rich protein expressed in heart and skeletal muscle. (PubMed id 9050928) 1 , 2 , 3, 9 Scartezzini P.... Rasore-Quartino A. (1997) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The DNA sequence of human chromosome 21. (PubMed id 10830953) 1 , 2 Hattori M....Yaspo M.L. (2000) Use of genome-wide expression data to mine the ' Gray Zone' of GWA studies leads to novel candidate obesity genes. (PubMed id 20532202) 1 Naukkarinen J....Peltonen L. (2010) Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. (PubMed id 18654987) 1 Thalappilly S....Dusetti N.J. (2008) Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. (PubMed id 16780588) 1 Hu Y.H....Janitz M. (2006) Heart morphogenesis is not affected by overexpression of the Sh3bgr gene mapping to the Down syndrome heart critical region. (PubMed id 14767758) 1 Sandri C....Schiaffino S. (2004) Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system. (PubMed id 12358155) 1 Jiang L.Q....Chen L.Y. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548) 1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for SH3BGR gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SH3BGR gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SH3BGR gene
(According to HUGE )
About This Section --
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Specialized Databases showing SH3BGR gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for SH3BGR Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for SH3BGR gene: Search GeneIP for patents involving SH3BGR GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SH3BGR gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for SH3BGR OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SH3BGR OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SH3BGR OriGene Protein Over-expression Lysate for SH3BGR Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SH3BGR OriGene 3'-UTR Clone for SH3BGR OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SH3BGR OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SH3BGR Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SH3BGR OriGene Custom Protein Services for SH3BGR OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SH3BGR QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SH3BGR QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH3BGR QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SH3BGR QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SH3BGR QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SH3BGR
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SH3BGR Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3BGR
ThermoFisher Antibodies for SH3BGR
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SH3BGR
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Aliases for SH3BGR
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Expression for SH3BGR
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