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Aliases for SH3BGR Gene

Aliases for SH3BGR Gene

  • SH3 Domain Binding Glutamate-Rich Protein 2 3
  • 21-Glutamic Acid-Rich Protein 2 3 4
  • SH3 Domain Binding Glutamic Acid-Rich Protein 2 3
  • 21-GARP 3 4
  • SH3-Binding Domain And Glutamic Acid-Rich Protein 3
  • SH3BGR Protein 4

External Ids for SH3BGR Gene

Previous GeneCards Identifiers for SH3BGR Gene

  • GC21P037398
  • GC21P039738
  • GC21P039744
  • GC21P039745
  • GC21P040817
  • GC21P026286

Summaries for SH3BGR Gene

GeneCards Summary for SH3BGR Gene

SH3BGR (SH3 Domain Binding Glutamate-Rich Protein) is a Protein Coding gene. GO annotations related to this gene include SH3 domain binding and SH3/SH2 adaptor activity. An important paralog of this gene is SH3BGRL3.

Gene Wiki entry for SH3BGR Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3BGR Gene

Genomics for SH3BGR Gene

Regulatory Elements for SH3BGR Gene

Genomic Location for SH3BGR Gene

Chromosome:
21
Start:
39,445,855 bp from pter
End:
39,515,506 bp from pter
Size:
69,652 bases
Orientation:
Plus strand

Genomic View for SH3BGR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SH3BGR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3BGR Gene

Proteins for SH3BGR Gene

  • Protein details for SH3BGR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55822-SH3BG_HUMAN
    Recommended name:
    SH3 domain-binding glutamic acid-rich protein
    Protein Accession:
    P55822
    Secondary Accessions:
    • A6ND59
    • D3DSI2
    • Q9BRB8

    Protein attributes for SH3BGR Gene

    Size:
    239 amino acids
    Molecular mass:
    26086 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SH3BGR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH3BGR Gene

Proteomics data for SH3BGR Gene at MOPED

Post-translational modifications for SH3BGR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SH3BGR Gene

Domains & Families for SH3BGR Gene

Protein Domains for SH3BGR Gene

Suggested Antigen Peptide Sequences for SH3BGR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55822

UniProtKB/Swiss-Prot:

SH3BG_HUMAN :
  • Belongs to the SH3BGR family.
Family:
  • Belongs to the SH3BGR family.
genes like me logo Genes that share domains with SH3BGR: view

No data available for Gene Families for SH3BGR Gene

Function for SH3BGR Gene

Molecular function for SH3BGR Gene

GENATLAS Biochemistry:
SH3 domain binding,glutamic acid rich protein,expressed only in heart and skeletal muscle

Gene Ontology (GO) - Molecular Function for SH3BGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 9050928
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with SH3BGR: view

Phenotypes for SH3BGR Gene

genes like me logo Genes that share phenotypes with SH3BGR: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SH3BGR Gene

Localization for SH3BGR Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SH3BGR Gene COMPARTMENTS Subcellular localization image for SH3BGR gene
Compartment Confidence
cytosol 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SH3BGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 16780588
genes like me logo Genes that share ontologies with SH3BGR: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SH3BGR Gene

Pathways & Interactions for SH3BGR Gene

SuperPathways for SH3BGR Gene

No Data Available

Interacting Proteins for SH3BGR Gene

Gene Ontology (GO) - Biological Process for SH3BGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly TAS 9050928
GO:0009967 positive regulation of signal transduction TAS 9050928
genes like me logo Genes that share ontologies with SH3BGR: view

No data available for Pathways by source and SIGNOR curated interactions for SH3BGR Gene

Drugs & Compounds for SH3BGR Gene

No Compound Related Data Available

Transcripts for SH3BGR Gene

Unigene Clusters for SH3BGR Gene

SH3 domain binding glutamic acid-rich protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SH3BGR Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: -
SP3:

Relevant External Links for SH3BGR Gene

GeneLoc Exon Structure for
SH3BGR
ECgene alternative splicing isoforms for
SH3BGR

Expression for SH3BGR Gene

mRNA expression in normal human tissues for SH3BGR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH3BGR Gene

This gene is overexpressed in Muscle - Skeletal (x15.9) and Heart - Left Ventricle (x5.4).

Protein differential expression in normal tissues from HIPED for SH3BGR Gene

This gene is overexpressed in Tonsil (21.5), Heart (18.8), and Oral epithelium (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SH3BGR Gene



SOURCE GeneReport for Unigene cluster for SH3BGR Gene Hs.473847

mRNA Expression by UniProt/SwissProt for SH3BGR Gene

P55822-SH3BG_HUMAN
Tissue specificity: Expressed in heart and skeletal muscle
genes like me logo Genes that share expression patterns with SH3BGR: view

Protein tissue co-expression partners for SH3BGR Gene

Primer Products

In Situ Assay Products

Orthologs for SH3BGR Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3BGR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SH3BGR 35
  • 99.16 (n)
  • 98.48 (a)
SH3BGR 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sh3bgr 16
Sh3bgr 36
  • 68 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SH3BGR 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 39 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia SH3BGR 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SH3BGR 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves SH3BGR 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SH3BGR 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75687 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24537 35
zebrafish
(Danio rerio)
Actinopterygii Dr.13487 35
sh3bgr 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sh3beta 36
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y105E8A.1 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for SH3BGR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3BGR Gene

ENSEMBL:
Gene Tree for SH3BGR (if available)
TreeFam:
Gene Tree for SH3BGR (if available)

Paralogs for SH3BGR Gene

Paralogs for SH3BGR Gene

(3) SIMAP similar genes for SH3BGR Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SH3BGR: view

Variants for SH3BGR Gene

Sequence variations from dbSNP and Humsavar for SH3BGR Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
VAR_028233 -
VAR_057182 -
VAR_057183 -

Structural Variations from Database of Genomic Variants (DGV) for SH3BGR Gene

Variant ID Type Subtype PubMed ID
dgv1373e1 CNV Complex 17122850
esv2723434 CNV Deletion 23290073
esv34779 CNV Gain 17911159

Variation tolerance for SH3BGR Gene

Residual Variation Intolerance Score: 87.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.82; 67.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH3BGR Gene

HapMap Linkage Disequilibrium report
SH3BGR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3BGR Gene

Disorders for SH3BGR Gene

Relevant External Links for SH3BGR

Genetic Association Database (GAD)
SH3BGR
Human Genome Epidemiology (HuGE) Navigator
SH3BGR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SH3BGR
genes like me logo Genes that share disorders with SH3BGR: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3BGR Gene

Publications for SH3BGR Gene

  1. Cloning a new human gene from chromosome 21q22.3 encoding a glutamic acid-rich protein expressed in heart and skeletal muscle. (PMID: 9050928) Scartezzini P. … Rasore-Quartino A. (Hum. Genet. 1997) 2 23 67
  2. Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PMID: 20532202) Naukkarinen J. … Peltonen L. (PLoS Genet. 2010) 67
  3. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung M.L. … Jeang K.T. (J. Biol. Chem. 2009) 67
  4. Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. (PMID: 18654987) Thalappilly S. … Dusetti N.J. (Proteomics 2008) 67
  5. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. (PMID: 16780588) Hu Y.H. … Janitz M. (BMC Genomics 2006) 67

Products for SH3BGR Gene

Sources for SH3BGR Gene

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