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Aliases for SH3BGR Gene

Aliases for SH3BGR Gene

  • SH3 Domain Binding Glutamate Rich Protein 2 3 5
  • 21-Glutamic Acid-Rich Protein 2 4
  • 21-GARP 3 4
  • SH3-Binding Domain And Glutamic Acid-Rich Protein 3
  • SH3 Domain Binding Glutamic Acid-Rich Protein 2
  • SH3 Domain-Binding Glutamic Acid-Rich Protein 3
  • SH3 Domain Binding Glutamate-Rich Protein 2
  • SH3BGR Protein 4

External Ids for SH3BGR Gene

Previous GeneCards Identifiers for SH3BGR Gene

  • GC21P037398
  • GC21P039738
  • GC21P039744
  • GC21P039745
  • GC21P040817
  • GC21P026286

Summaries for SH3BGR Gene

GeneCards Summary for SH3BGR Gene

SH3BGR (SH3 Domain Binding Glutamate Rich Protein) is a Protein Coding gene. GO annotations related to this gene include SH3 domain binding and SH3/SH2 adaptor activity. An important paralog of this gene is SH3BGRL.

Gene Wiki entry for SH3BGR Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3BGR Gene

Genomics for SH3BGR Gene

Regulatory Elements for SH3BGR Gene

Enhancers for SH3BGR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21G039450 1.5 FANTOM5 Ensembl ENCODE 28.7 +6.5 6476 3.9 PKNOX1 FOXA2 ATF1 CREB3L1 SIN3A FEZF1 YY1 ELK1 FOS KLF13 LCA5L SH3BGR WRB BRWD1 PCP4 MIR6508 GC21P039465
GH21G039444 1.1 ENCODE 28.4 -0.3 -349 2.3 PKNOX1 CREB3L1 AGO1 ARID4B SIN3A ZNF2 ZNF766 ZNF207 ZNF143 ZNF548 LCA5L SH3BGR WRB GC21P039407
GH21G039441 1.1 FANTOM5 ENCODE 27.7 -3.7 -3734 1.9 CTCF RB1 ARNT RAD21 RFX5 FOSL1 ZFHX2 ZNF143 SMC3 NR2F6 LCA5L SH3BGR GC21P039407
GH21G039384 1.1 ENCODE 11.7 -58.9 -58857 4.6 HDGF PKNOX1 MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 WRB HMGN1 SH3BGR BRWD1 LCA5L GC21P039407
GH21G039422 0.9 ENCODE 11.4 -23.3 -23292 1.0 HDAC1 PKNOX1 CBX3 ARNT TCF12 ZNF766 RELB IKZF2 CREM CEBPB LCA5L SH3BGR HMGN1 GC21P039407
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SH3BGR on UCSC Golden Path with GeneCards custom track

Promoters for SH3BGR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000142481 -155 1401 PKNOX1 CREB3L1 AGO1 ARID4B SIN3A ZNF2 ZNF766 ZNF207 ZNF143 ZNF548

Genomic Location for SH3BGR Gene

Chromosome:
21
Start:
39,445,855 bp from pter
End:
39,515,506 bp from pter
Size:
69,652 bases
Orientation:
Plus strand

Genomic View for SH3BGR Gene

Genes around SH3BGR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH3BGR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH3BGR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3BGR Gene

Proteins for SH3BGR Gene

  • Protein details for SH3BGR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55822-SH3BG_HUMAN
    Recommended name:
    SH3 domain-binding glutamic acid-rich protein
    Protein Accession:
    P55822
    Secondary Accessions:
    • A6ND59
    • D3DSI2
    • Q9BRB8

    Protein attributes for SH3BGR Gene

    Size:
    239 amino acids
    Molecular mass:
    26086 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SH3BGR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH3BGR Gene

Post-translational modifications for SH3BGR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SH3BGR Gene

Domains & Families for SH3BGR Gene

Protein Domains for SH3BGR Gene

Suggested Antigen Peptide Sequences for SH3BGR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55822

UniProtKB/Swiss-Prot:

SH3BG_HUMAN :
  • Belongs to the SH3BGR family.
Family:
  • Belongs to the SH3BGR family.
genes like me logo Genes that share domains with SH3BGR: view

No data available for Gene Families for SH3BGR Gene

Function for SH3BGR Gene

Molecular function for SH3BGR Gene

GENATLAS Biochemistry:
SH3 domain binding,glutamic acid rich protein,expressed only in heart and skeletal muscle

Gene Ontology (GO) - Molecular Function for SH3BGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 9050928
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with SH3BGR: view
genes like me logo Genes that share phenotypes with SH3BGR: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SH3BGR Gene

Localization for SH3BGR Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH3BGR gene
Compartment Confidence
cytosol 5
plasma membrane 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SH3BGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 16780588
genes like me logo Genes that share ontologies with SH3BGR: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SH3BGR Gene

Pathways & Interactions for SH3BGR Gene

SuperPathways for SH3BGR Gene

No Data Available

Interacting Proteins for SH3BGR Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000332513%0d%0a9606.ENSP00000224784%0d%0a9606.ENSP00000290378%0d%0a9606.ENSP00000297283%0d%0a9606.ENSP00000308759%0d%0a9606.ENSP00000459216%0d%0a
Selected Interacting proteins: ENSP00000332513 P55822-SH3BG_HUMAN for SH3BGR Gene via STRING IID

Gene Ontology (GO) - Biological Process for SH3BGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly TAS 9050928
GO:0009967 positive regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with SH3BGR: view

No data available for Pathways by source and SIGNOR curated interactions for SH3BGR Gene

Drugs & Compounds for SH3BGR Gene

No Compound Related Data Available

Transcripts for SH3BGR Gene

Unigene Clusters for SH3BGR Gene

SH3 domain binding glutamic acid-rich protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH3BGR Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: -
SP3:

Relevant External Links for SH3BGR Gene

GeneLoc Exon Structure for
SH3BGR
ECgene alternative splicing isoforms for
SH3BGR

Expression for SH3BGR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SH3BGR Gene

mRNA differential expression in normal tissues according to GTEx for SH3BGR Gene

This gene is overexpressed in Muscle - Skeletal (x15.9) and Heart - Left Ventricle (x5.4).

Protein differential expression in normal tissues from HIPED for SH3BGR Gene

This gene is overexpressed in Tonsil (21.5), Heart (18.8), and Oral epithelium (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SH3BGR Gene



Protein tissue co-expression partners for SH3BGR Gene

NURSA nuclear receptor signaling pathways regulating expression of SH3BGR Gene:

SH3BGR

SOURCE GeneReport for Unigene cluster for SH3BGR Gene:

Hs.473847

mRNA Expression by UniProt/SwissProt for SH3BGR Gene:

P55822-SH3BG_HUMAN
Tissue specificity: Expressed in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for SH3BGR Gene

  • Heart(4.6)
  • Muscle(4.6)
genes like me logo Genes that share expression patterns with SH3BGR: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SH3BGR Gene

Orthologs for SH3BGR Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3BGR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SH3BGR 34 35
  • 99.16 (n)
cow
(Bos Taurus)
Mammalia SH3BGR 35
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sh3bgr 35
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SH3BGR 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SH3BGR 35
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 39 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SH3BGR 35
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SH3BGR 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75687 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24537 34
zebrafish
(Danio rerio)
Actinopterygii sh3bgr 35
  • 50 (a)
OneToOne
Dr.13487 34
fruit fly
(Drosophila melanogaster)
Insecta Sh3beta 35
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y105E8A.1 35
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToMany
Species where no ortholog for SH3BGR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3BGR Gene

ENSEMBL:
Gene Tree for SH3BGR (if available)
TreeFam:
Gene Tree for SH3BGR (if available)

Paralogs for SH3BGR Gene

Paralogs for SH3BGR Gene

(3) SIMAP similar genes for SH3BGR Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SH3BGR: view

Variants for SH3BGR Gene

Sequence variations from dbSNP and Humsavar for SH3BGR Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1000053625 -- 39,461,689(+) TGACT(C/G)AAACT intron-variant
rs1000111115 -- 39,507,678(+) TCTTA(C/T)TTTGT intron-variant
rs1000134360 -- 39,445,607(+) CTGAG(G/T)GACCG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000193512 -- 39,489,492(+) CTTCC(A/G)TCCTG intron-variant
rs1000238207 -- 39,486,120(+) ATTAC(A/G)AATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH3BGR Gene

Variant ID Type Subtype PubMed ID
esv2723434 CNV deletion 23290073
esv2758820 CNV gain 17122850
esv34779 CNV gain 17911159
esv3557717 CNV deletion 23714750
nsv1061454 CNV gain 25217958
nsv1067330 CNV loss 25217958
nsv1126006 CNV deletion 24896259
nsv964496 CNV duplication 23825009

Variation tolerance for SH3BGR Gene

Residual Variation Intolerance Score: 87.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.82; 67.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH3BGR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SH3BGR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH3BGR Gene

Disorders for SH3BGR Gene

Relevant External Links for SH3BGR

Genetic Association Database (GAD)
SH3BGR
Human Genome Epidemiology (HuGE) Navigator
SH3BGR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SH3BGR

No disorders were found for SH3BGR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH3BGR Gene

Publications for SH3BGR Gene

  1. Cloning a new human gene from chromosome 21q22.3 encoding a glutamic acid-rich protein expressed in heart and skeletal muscle. (PMID: 9050928) Scartezzini P. … Rasore-Quartino A. (Hum. Genet. 1997) 2 3 4 22 64
  2. Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PMID: 20532202) Naukkarinen J. … Peltonen L. (PLoS Genet. 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4 64
  5. Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners. (PMID: 27100087) Alves da Silva A.F. … Medina-Acosta E. (PLoS ONE 2016) 3 64

Products for SH3BGR Gene

Sources for SH3BGR Gene

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