Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SH3BGR Gene

protein-coding   GIFtS: 55
GCID: GC21P040817

SH3 Domain Binding Glutamate-Rich Protein

(Previous name: SH3 domain binding glutamic acid-rich protein)
  Search for SH3BGR
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

TryGeneCards Plus

Aliases
SH3 Domain Binding Glutamate-Rich Protein1 2     SH3 Domain-Binding Glutamic Acid-Rich Protein2
21-Glutamic Acid-Rich Protein1 2 3     SH3-Binding Domain And Glutamic Acid-Rich Protein2
SH3 Domain Binding Glutamic Acid-Rich Protein1 2     SH3BGR Protein3
21-GARP2 3     SH3GBR5
21-Glutamic Acid-Rich Protein (21-GARP)11     

External Ids:    HGNC: 108221   Entrez Gene: 64502   Ensembl: ENSG000001854377   OMIM: 6022305   UniProtKB: P558223   

Export aliases for SH3BGR gene to outside databases

Previous GC identifers: GC21P037398 GC21P039738 GC21P039744 GC21P039745 GC21P026286


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SH3BGR Gene:
SH3BGR (SH3 domain binding glutamate-rich protein) is a protein-coding gene. GO annotations related to this gene include SH3/SH2 adaptor activity and SH3 domain binding. An important paralog of this gene is SH3BGRL2.

Gene Wiki entry for SH3BGR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SH3BGR gene promoter:
         CREB   c-Rel   RFX1   deltaCREB   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SH3BGR promoter sequence

   Search Chromatin IP Primers for SH3BGR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SH3BGR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.2   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.2
SH3BGR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SH3BGR gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P040817:   GeneLoc Nature:405,311-319
Start:
40,817,781 bp from pter       26,397,539 bp from centromere
End:
40,887,433 bp from pter 26,461,157 bp from centromere
Size:
69,653 bases 63,619 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: X93498
genomic clones: P1031P17 to P70I24


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SH3BG_HUMAN, P55822 (See protein sequence)
Recommended Name: SH3 domain-binding glutamic acid-rich protein  
Size: 239 amino acids; 26086 Da
Caution: It is uncertain whether Met-1 or Met-64 is the initiator
Secondary accessions: A6ND59 D3DSI2 Q9BRB8
Alternative splicing: 2 isoforms:  P55822-1   P55822-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SH3BGR: NX_P55822

Explore proteomics data for SH3BGR at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SH3BGR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001001713.1  NP_031367.1  

    ENSEMBL proteins: 
     ENSP00000370011   ENSP00000370008   ENSP00000404980   ENSP00000401572   ENSP00000370005  
     ENSP00000332513   ENSP00000405675   ENSP00000413981   ENSP00000403115  

    SH3BGR Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SH3BGR
    OriGene Protein Over-expression Lysate for SH3BGR
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SH3BGR
    GenScript Custom Purified and Recombinant Proteins Services for SH3BGR
    Novus Biologicals SH3BGR Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SH3BGR

     
    Search eBioscience for Proteins for SH3BGR 

    SH3BGR Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SH3BGR
    OriGene Custom Antibody Services for SH3BGR
    Novus Biologicals SH3BGR Antibodies
    Abcam antibodies for SH3BGR (P55822, Q16629)
    Cloud-Clone Corp. Antibodies for SH3BGR
    ThermoFisher Antibodies for SH3BGR
    LSBio Antibodies in human, mouse, rat for SH3BGR

    SH3BGR Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SH3BGR
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SH3BGR
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SH3BGR
    Cloud-Clone Corp. CLIAs for SH3BGR
    Search eBioscience for ELISAs for SH3BGR 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR006993 Glut_rich_SH3-bd
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry P55822

    ProtoNet protein and cluster: P55822

    1 Blocks protein domain: IPB006993 SH3-binding

    UniProtKB/Swiss-Prot: SH3BG_HUMAN, P55822
    Similarity: Belongs to the SH3BGR family


    Find genes that share domains with SH3BGR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:
         Genatlas biochemistry entry for SH3BGR:
    SH3 domain binding,glutamic acid rich protein,expressed only in heart and skeletal muscle

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity TAS9050928
    GO:0017124SH3 domain binding IEA--
         
    Find genes that share ontologies with SH3BGR           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SH3BGR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SH3BGR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SH3BGR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SH3BGR

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SH3BGR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SH3BGR (see all 10):
    hsa-miR-3678-3p hsa-miR-203 hsa-miR-875-3p hsa-miR-330-5p hsa-miR-130a* hsa-miR-23c hsa-miR-23b hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmidSH3BGR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SH3BGR
    Predesigned siRNA for gene silencing in human, mouse, rat SH3BGR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SH3BGR

    Clone
    Products:
         
    OriGene clones in human, mouse for SH3BGR (see all 11)
    OriGene ORF clones in mouse, rat for SH3BGR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SH3BGR (NM_007341)
    Sino Biological Human cDNA Clone for SH3BGR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SH3BGR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH3BGR

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SH3BGR
    Browse ESI BIO Cell Lines and PureStem Progenitors for SH3BGR 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3BGR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus2
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IDA16780588

    Find genes that share ontologies with SH3BGR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SH3BGR
    Interactions:

        Search GeneGlobe Interaction Network for SH3BGR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SH3BGR (P558223 ENSP000003325134) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAPN1P073843, ENSP000002792474I2D: score=2 STRING: ENSP00000279247
    FCHSD2O948683, ENSP000003867224I2D: score=1 STRING: ENSP00000386722
    CAPN3ENSP000003803494STRING: ENSP00000380349
    TALDO1ENSP000003212594STRING: ENSP00000321259
    TXNL4AENSP000002696014STRING: ENSP00000269601
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly TAS9050928
    GO:0009967positive regulation of signal transduction TAS9050928

    Find genes that share ontologies with SH3BGR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SH3BGR (SH3BG)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SH3BGR gene (2 alternative transcripts): 
    NM_001001713.1  NM_007341.2  

    Unigene Cluster for SH3BGR:

    SH3 domain binding glutamic acid-rich protein
    Hs.473847  [show with all ESTs]
    Unigene Representative Sequence: NM_007341
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380637(uc002yxz.3) ENST00000380634 ENST00000458295 ENST00000440288
    ENST00000380631 ENST00000333634(uc002yya.3) ENST00000452550 ENST00000423596
    ENST00000447939
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SH3BGR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SH3BGR (see all 10):
    hsa-miR-3678-3p hsa-miR-203 hsa-miR-875-3p hsa-miR-330-5p hsa-miR-130a* hsa-miR-23c hsa-miR-23b hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmidSH3BGR 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SH3BGR
    Predesigned siRNA for gene silencing in human, mouse, rat SH3BGR
    Clone
    Products:
         
    OriGene clones in human, mouse for SH3BGR (see all 11)
    OriGene ORF clones in mouse, rat for SH3BGR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SH3BGR (NM_007341)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SH3BGR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH3BGR
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SH3BGR
    OriGene qSTAR qPCR primer pairs in human, mouse for SH3BGR
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SH3BGR
      QuantiTect SYBR Green Assays in human, mouse, rat SH3BGR
      QuantiFast Probe-based Assays in human, mouse, rat SH3BGR

    Additional mRNA sequence: 

    BC006371.2 BT006994.1 X93498.1 

    8 DOTS entries:

    DT.102834035  DT.311166  DT.121139415  DT.95268325  DT.97841175  DT.121139456  DT.121139386  DT.91895956 

    Selected AceView cDNA sequences (see all 393):

    BX092195 BU729884 BM470417 BE644931 BU734633 BP368925 NM_007341 CR618183 
    CA391782 AI401072 AI699511 AA687449 F29744 AI631271 AI076545 AA627711 
    CB113614 CB114295 AI934908 AA247739 BM128577 AI583388 AU142922 BQ771788 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SH3BGR    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
    SP1:                                                      
    SP2:                                -                     
    SP3:                                                      


    ECgene alternative splicing isoforms for SH3BGR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SH3BGR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGTTCTCT
    SH3BGR Expression
    About this image


    SH3BGR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Heart Tube
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Brain (Nervous System)
             Cerebellum
    SH3BGR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SH3BGR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.473847

    UniProtKB/Swiss-Prot: SH3BG_HUMAN, P55822
    Tissue specificity: Expressed in heart and skeletal muscle

        Custom PCR Arrays for SH3BGR
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SH3BGR
    OriGene qSTAR qPCR primer pairs in human, mouse for SH3BGR
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SH3BGR
    QuantiTect SYBR Green Assays in human, mouse, rat SH3BGR
    QuantiFast Probe-based Assays in human, mouse, rat SH3BGR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3BGR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SH3BGR gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sh3bgr5 SH3-binding domain glutamic acid-rich protein   --   16 (56.86 cM) 96200470 
    chicken
    (Gallus gallus)
    Aves SH3BGR6
    SH3 domain binding glutamic acid-rich protein
    88(a)
    1 ↔ 1
    1(107392917-107418544)
    lizard
    (Anolis carolinensis)
    Reptilia SH3BGR6
    SH3 domain binding glutamic acid-rich protein
    50(a)
    1 ↔ 1
    3(139595125-139638556)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.245372 Xenopus laevis transcribed sequence with moderate similarity more 76.09(n)    BJ058013.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.134872 Transcribed sequence with weak similarity to protein more 73.83(n)    BI865553.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sh3beta6
    Sh3beta
    14(a)
    1 → many
    3L(7357684-7362360)
    worm
    (Caenorhabditis elegans)
    Secernentea Y105E8A.16
    Protein Y105E8A.1, isoform b
    25(a)
    1 → many
    I(14341520-14343805) WBGene00013666


    ENSEMBL Gene Tree for SH3BGR (if available)
    TreeFam Gene Tree for SH3BGR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SH3BGR gene
    SH3BGRL22  SH3BGRL2  SH3BGRL32  
    3 SIMAP similar genes for SH3BGR using alignment to 6 protein entries:     SH3BG_HUMAN (see all proteins):
    SH3BGRL    SH3BGRL2    SH3BGRL3

    Find genes that share paralogs with SH3BGR           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SH3BGR (see all 1446)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs782806141,2
    F--40818216(+) AGTTAT/CAGATG 1 -- int11Minor allele frequency- C:0.01WA 118
    rs1808698531,2
    --40818260(+) TTAGGA/GAGACT 1 -- int10--------
    rs28370351,2
    C,F,O,H--40818379(+) TTCCTA/GCAAGC 1 -- int129Minor allele frequency- N:0.00NA EA NS CSA WA 2997
    rs1459864401,2
    C--40818403(+) AAAGC-/ATATATG 1 -- int10--------
    rs2011574791,2
    --40818404(+) AAGCA-/TTATGC 1 -- int10--------
    rs1168861151,2
    C,F--40818586(+) TTCCCA/GTATCT 1 -- int11Minor allele frequency- G:0.03NA 120
    rs1836217271,2
    --40818784(+) TTGGTA/GTTTGT 1 -- int10--------
    rs1460030911,2
    --40818892(+) CTTTGA/GTAGAA 1 -- int10--------
    rs1892192991,2
    --40818911(+) GGACAA/GGCTTT 1 -- int10--------
    rs1398417701,2
    C--40818927(+) CATATC/TACCAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for SH3BGR (40817781 - 40887433 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SH3BGR:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2723434CNV Deletion23290073
    esv34779CNV Gain17911159
    dgv1373e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SH3BGR
    DNA2.0 Custom Variant and Variant Library Synthesis for SH3BGR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602230    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for SH3BGR:
    Down syndrome

    Find genes that share disorders with SH3BGR           About GenesLikeMe

    Genetic Association Database (GAD): SH3BGR
    Human Genome Epidemiology (HuGE) Navigator: SH3BGR (1 document)

    Export disorders for SH3BGR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SH3BGR gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with SH3BGR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning a new human gene from chromosome 21q22.3 encoding a glutamic acid-rich protein expressed in heart and skeletal muscle. (PubMed id 9050928)1, 2, 3, 9 Scartezzini P.... Rasore-Quartino A. (Hum. Genet. 1997)
    2. Use of genome-wide expression data to mine the &quot;Gray Zone&quot; of GWA studies leads to novel candidate obesity genes. (PubMed id 20532202)1, 4 Naukkarinen J....Peltonen L. (PLoS Genet. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PubMed id 19460752)1 Yeung M.L....Jeang K.T. (J. Biol. Chem. 2009)
    7. Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. (PubMed id 18654987)1 Thalappilly S....Dusetti N.J. (Proteomics 2008)
    8. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. (PubMed id 16780588)1 Hu Y.H....Janitz M. (BMC Genomics 2006)
    9. Heart morphogenesis is not affected by overexpression of the Sh3bgr gene mapping to the Down syndrome heart critical region. (PubMed id 14767758)1 Sandri C....Schiaffino S. (Hum. Genet. 2004)
    10. Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system. (PubMed id 12358155)1 Jiang L.Q....Chen L.Y. (Hypertens. Res. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6450 HGNC: 10822 AceView: WRBandSH3BGR Ensembl:ENSG00000185437 euGenes: HUgn6450
    ECgene: SH3BGR H-InvDB: SH3BGR

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SH3BGR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SH3BGR gene:
    Search GeneIP for patents involving SH3BGR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SH3BGR   OriGene RNAi products in human, mouse, rat for SH3BGR  
     OriGene qPCR primer pairs and template standards for SH3BGR   OriGene Protein Over-expression Lysate for SH3BGR  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SH3BGR  
     OriGene qSTAR qPCR primer pairs in human, mouse for SH3BGR   OriGene Purified Protein for SH3BGR  
     OriGene ORF clones in mouse, rat for SH3BGR   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SH3BGR   OriGene Custom Protein Services for SH3BGR  

     
     
     Block miRNA regulation of human, mouse, rat SH3BGR using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SH3BGR
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SH3BGR Predesigned siRNA for gene silencing in human, mouse, rat SH3BGR
     QuantiFast Probe-based Assays in human, mouse, rat SH3BGR QuantiTect SYBR Green Assays in human, mouse, rat SH3BGR
     Custom PCR Arrays for SH3BGR Search Chromatin IP Primers for SH3BGR
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SH3BGR  Search GeneGlobe Interaction Network for SH3BGR
     Regulatory tfbs in SH3BGR promoter
     GenScript Custom Purified and Recombinant Proteins Services for SH3BGR GenScript cDNA clones with any tag delivered in your preferred vector for SH3BGR
     GenScript Custom Assay Services for SH3BGR GenScript Custom overexpressing Cell Line Services for SH3BGR
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SH3BGR (SH3BG)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for SH3BGR
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SH3BGR antibodies
     SH3BGR proteins
     Antibodies for SH3BGR
     See all of Abcam's Antibodies, Kits and Proteins for SH3BGR
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SH3BGR
     Antibodies for SH3BGR
     ELISAs for SH3BGR
     CLIAs for SH3BGR



     Browse ESI BIO Cell Lines and PureStem Progenitors for SH3BGR
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH3BGR
     SwitchGear 3'UTR luciferase reporter plasmids for SH3BGR
     SwitchGear Promoter luciferase reporter plasmids for SH3BGR
     ThermoFisher Antibodies for SH3BGR
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH3BGR
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SH3BGR
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SH3BGR
     LSBio Antibodies in human, mouse, rat for SH3BGR
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for SH3BGR
      Search eBioscience for proteins for SH3BGR
      Search eBioscience for elisas for SH3BGR
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SH3BGR gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4