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Aliases for SH2D7 Gene

Aliases for SH2D7 Gene

  • SH2 Domain Containing 7 2 3 5
  • Putative SH2 Domain-Containing Protein LOC646892 3
  • SH2 Domain-Containing Protein 7 3
  • HCG38941 3

External Ids for SH2D7 Gene

Previous GeneCards Identifiers for SH2D7 Gene

  • GC15P076158
  • GC15P078370
  • GC15P055142

Summaries for SH2D7 Gene

GeneCards Summary for SH2D7 Gene

SH2D7 (SH2 Domain Containing 7) is a Protein Coding gene. An important paralog of this gene is SH2D2A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2D7 Gene

Genomics for SH2D7 Gene

Regulatory Elements for SH2D7 Gene

Enhancers for SH2D7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SH2D7 on UCSC Golden Path with GeneCards custom track

Promoters for SH2D7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SH2D7 Gene

78,077,805 bp from pter
78,104,909 bp from pter
27,105 bases
Plus strand

Genomic View for SH2D7 Gene

Genes around SH2D7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH2D7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH2D7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D7 Gene

Proteins for SH2D7 Gene

  • Protein details for SH2D7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH2 domain-containing protein 7
    Protein Accession:

    Protein attributes for SH2D7 Gene

    451 amino acids
    Molecular mass:
    49807 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SH2D7 Gene

Post-translational modifications for SH2D7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH2D7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SH2D7 Gene

Domains & Families for SH2D7 Gene

Gene Families for SH2D7 Gene

Protein Domains for SH2D7 Gene


Suggested Antigen Peptide Sequences for SH2D7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SH2 domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SH2D7: view

Function for SH2D7 Gene

Phenotypes for SH2D7 Gene

GenomeRNAi human phenotypes for SH2D7:
genes like me logo Genes that share phenotypes with SH2D7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SH2D7 Gene

Localization for SH2D7 Gene

Subcellular locations from

Jensen Localization Image for SH2D7 Gene COMPARTMENTS Subcellular localization image for SH2D7 gene
Compartment Confidence
cytosol 3
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SH2D7 Gene

Pathways & Interactions for SH2D7 Gene

SuperPathways for SH2D7 Gene

No Data Available

Interacting Proteins for SH2D7 Gene

Gene Ontology (GO) - Biological Process for SH2D7 Gene


No data available for Pathways by source and SIGNOR curated interactions for SH2D7 Gene

Drugs & Compounds for SH2D7 Gene

No Compound Related Data Available

Transcripts for SH2D7 Gene

mRNA/cDNA for SH2D7 Gene

(6) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SH2D7 Gene

SH2 domain containing 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D7 Gene

No ASD Table

Relevant External Links for SH2D7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH2D7 Gene

mRNA expression in normal human tissues for SH2D7 Gene

mRNA differential expression in normal tissues according to GTEx for SH2D7 Gene

This gene is overexpressed in Testis (x14.2), Colon - Transverse (x8.8), and Small Intestine - Terminal Ileum (x5.0).

Protein differential expression in normal tissues from HIPED for SH2D7 Gene

This gene is overexpressed in Adipocyte (61.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SH2D7 Gene

Protein tissue co-expression partners for SH2D7 Gene

NURSA nuclear receptor signaling pathways regulating expression of SH2D7 Gene:


SOURCE GeneReport for Unigene cluster for SH2D7 Gene:

genes like me logo Genes that share expression patterns with SH2D7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SH2D7 Gene

Orthologs for SH2D7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH2D7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SH2D7 34
  • 79.97 (n)
  • 75.12 (a)
SH2D7 35
  • 68 (a)
(Canis familiaris)
Mammalia SH2D7 34
  • 73.2 (n)
  • 55.78 (a)
SH2D7 35
  • 55 (a)
(Mus musculus)
Mammalia Sh2d7 34
  • 76.36 (n)
  • 61.45 (a)
Sh2d7 16
Sh2d7 35
  • 59 (a)
(Pan troglodytes)
Mammalia SH2D7 34
  • 90.17 (n)
  • 86.92 (a)
SH2D7 35
  • 96 (a)
(Rattus norvegicus)
Mammalia Sh2d7 34
  • 76.54 (n)
  • 66.82 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 41 (a)
(Danio rerio)
Actinopterygii SH2D7 (1 of 2) 35
  • 3 (a)
SH2D7 (2 of 2) 35
  • 3 (a)
(Caenorhabditis elegans)
Secernentea F13B12.6 35
  • 8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 7 (a)
Species where no ortholog for SH2D7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SH2D7 Gene

Gene Tree for SH2D7 (if available)
Gene Tree for SH2D7 (if available)

Paralogs for SH2D7 Gene

Paralogs for SH2D7 Gene

genes like me logo Genes that share paralogs with SH2D7: view

Variants for SH2D7 Gene

Sequence variations from dbSNP and Humsavar for SH2D7 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs2289524 - 78,098,072(-) TCAGC(A/G)TCTCT reference, missense
rs12593575 - 78,098,567(+) GTCCC(A/C/T)GGAAC reference, missense
rs2867922 -- 78,099,627(-) TCCTT(C/T)GGCCA intron-variant
rs2867926 -- 78,084,036(-) tgttg(A/T)acgtc intron-variant
rs2903700 -- 78,099,616(-) agcgc(G/T)gtggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH2D7 Gene

Variant ID Type Subtype PubMed ID
esv3636978 CNV loss 21293372
nsv1116464 OTHER inversion 24896259

Variation tolerance for SH2D7 Gene

Residual Variation Intolerance Score: 94.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH2D7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH2D7 Gene

Disorders for SH2D7 Gene

Relevant External Links for SH2D7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SH2D7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH2D7 Gene

Publications for SH2D7 Gene

  1. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 3 4 65
  2. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3 65

Products for SH2D7 Gene

Sources for SH2D7 Gene

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