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Aliases for SH2D7 Gene

Aliases for SH2D7 Gene

  • SH2 Domain Containing 7 2 3 5
  • Putative SH2 Domain-Containing Protein LOC646892 3
  • SH2 Domain-Containing Protein 7 3
  • HCG38941 3

External Ids for SH2D7 Gene

Previous GeneCards Identifiers for SH2D7 Gene

  • GC15P076158
  • GC15P078370
  • GC15P055142

Summaries for SH2D7 Gene

GeneCards Summary for SH2D7 Gene

SH2D7 (SH2 Domain Containing 7) is a Protein Coding gene. An important paralog of this gene is HSH2D.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2D7 Gene

Genomics for SH2D7 Gene

Regulatory Elements for SH2D7 Gene

Enhancers for SH2D7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F078042 1.7 FANTOM5 Ensembl ENCODE 13 -26.5 -26532 18.4 HDGF PKNOX1 ZFP64 SIN3A FEZF1 ZNF48 ZNF2 ZNF121 FOS SP5 TBC1D2B ENSG00000259562 IREB2 LOC645752 SH2D7 ADAMTS7P3 ENSG00000199633 ENSG00000260988 CIB2 LOC440292
GH15F078100 1.2 Ensembl ENCODE 12.7 +25.9 25920 6.0 HDGF PKNOX1 KLF17 ZNF2 ZBTB40 RAD21 ZNF121 SCRT2 ZNF143 RCOR1 CIB2 TBC1D2B SH2D7 PIR50456 ENSG00000199633 GC15M078092
GH15F078146 1.4 Ensembl ENCODE 10.7 +70.8 70831 5.2 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF263 SP3 WDR61 IDH3A LOC105370911 LOC105370908 RN7SL214P LOC105370907 RPL18P11 LOC646938 LOC646853 ENSG00000259562
GH15F078006 1.1 ENCODE 12.4 -70.0 -70033 2.9 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 ENSG00000259322 TBC1D2B SH2D7 ENSG00000199633 GC15M078014 PIR35295 PIR48785 GC15M078002
GH15F077957 1.1 Ensembl ENCODE 11.5 -118.9 -118936 2.7 SIN3A ZNF2 RAD21 RFX5 ZNF143 RCOR1 ZNF654 JUNB REST MTA1 LOC645752 SH2D7 TBC1D2B ENSG00000199633 LOC105370908 LOC440292
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SH2D7 on UCSC Golden Path with GeneCards custom track

Promoters for SH2D7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000411845 -905 3001 HDGF ARID4B SIN3A DMAP1 ZNF48 ZNF2 ZNF121 GLIS2 ZNF143 FOS

Genomic Location for SH2D7 Gene

78,077,805 bp from pter
78,104,909 bp from pter
27,105 bases
Plus strand

Genomic View for SH2D7 Gene

Genes around SH2D7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH2D7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH2D7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D7 Gene

Proteins for SH2D7 Gene

  • Protein details for SH2D7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH2 domain-containing protein 7
    Protein Accession:

    Protein attributes for SH2D7 Gene

    451 amino acids
    Molecular mass:
    49807 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SH2D7 Gene

Post-translational modifications for SH2D7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH2D7 Gene

No data available for DME Specific Peptides for SH2D7 Gene

Domains & Families for SH2D7 Gene

Gene Families for SH2D7 Gene

Protein Domains for SH2D7 Gene


Suggested Antigen Peptide Sequences for SH2D7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SH2 domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SH2D7: view

Function for SH2D7 Gene

Phenotypes for SH2D7 Gene

GenomeRNAi human phenotypes for SH2D7:
genes like me logo Genes that share phenotypes with SH2D7: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SH2D7 Gene

Localization for SH2D7 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH2D7 gene
Compartment Confidence
nucleus 3
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SH2D7 Gene

Pathways & Interactions for SH2D7 Gene

SuperPathways for SH2D7 Gene

No Data Available

Interacting Proteins for SH2D7 Gene

Gene Ontology (GO) - Biological Process for SH2D7 Gene


No data available for Pathways by source and SIGNOR curated interactions for SH2D7 Gene

Transcripts for SH2D7 Gene

mRNA/cDNA for SH2D7 Gene

(6) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SH2D7 Gene

SH2 domain containing 7:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D7 Gene

No ASD Table

Relevant External Links for SH2D7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH2D7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SH2D7 Gene

mRNA differential expression in normal tissues according to GTEx for SH2D7 Gene

This gene is overexpressed in Testis (x14.2), Colon - Transverse (x8.8), and Small Intestine - Terminal Ileum (x5.0).

Protein differential expression in normal tissues from HIPED for SH2D7 Gene

This gene is overexpressed in Adipocyte (61.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SH2D7 Gene

Protein tissue co-expression partners for SH2D7 Gene

NURSA nuclear receptor signaling pathways regulating expression of SH2D7 Gene:


SOURCE GeneReport for Unigene cluster for SH2D7 Gene:

genes like me logo Genes that share expression patterns with SH2D7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SH2D7 Gene

Orthologs for SH2D7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH2D7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SH2D7 34 35
  • 90.17 (n)
(Bos Taurus)
Mammalia SH2D7 34 35
  • 79.97 (n)
(Rattus norvegicus)
Mammalia Sh2d7 34
  • 76.54 (n)
(Mus musculus)
Mammalia Sh2d7 34 16 35
  • 76.36 (n)
(Canis familiaris)
Mammalia SH2D7 34 35
  • 73.2 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 41 (a)
(Danio rerio)
Actinopterygii SH2D7 (1 of 2) 35
  • 3 (a)
SH2D7 (2 of 2) 35
  • 3 (a)
(Caenorhabditis elegans)
Secernentea F13B12.6 35
  • 8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 7 (a)
Species where no ortholog for SH2D7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SH2D7 Gene

Gene Tree for SH2D7 (if available)
Gene Tree for SH2D7 (if available)

Paralogs for SH2D7 Gene

Paralogs for SH2D7 Gene

genes like me logo Genes that share paralogs with SH2D7: view

Variants for SH2D7 Gene

Sequence variations from dbSNP and Humsavar for SH2D7 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs111355664 -- 78,089,812(+) TAGGT(A/G)TGAGC upstream-variant-2KB
rs112148755 -- 78,096,661(+) GGCTA(-/T)TTTTT intron-variant, upstream-variant-2KB
rs112149948 -- 78,101,720(+) GTGGT(A/G)GTGGT intron-variant, utr-variant-3-prime
rs112167446 -- 78,095,752(+) CCAAG(-/A)TTTTT intron-variant, upstream-variant-2KB
rs112279712 -- 78,103,048(+) CACAT(C/T)CCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH2D7 Gene

Variant ID Type Subtype PubMed ID
esv3636978 CNV loss 21293372
nsv1116464 OTHER inversion 24896259

Variation tolerance for SH2D7 Gene

Residual Variation Intolerance Score: 94.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH2D7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH2D7 Gene

Disorders for SH2D7 Gene

Relevant External Links for SH2D7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SH2D7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH2D7 Gene

Publications for SH2D7 Gene

  1. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 3 4 64
  2. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3 64

Products for SH2D7 Gene

Sources for SH2D7 Gene

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