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SH2D7 Gene

protein-coding   GIFtS: 31
GCID: GC15P078370

SH2 Domain Containing 7

  Search for SH2D7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SH2 Domain Containing 71 2
hCG389412
Putative SH2 Domain-Containing Protein LOC6468922
SH2 Domain-Containing Protein 72

External Ids:    HGNC: 345491   Entrez Gene: 6468922   Ensembl: ENSG000001834767   UniProtKB: A6NKC93   

Export aliases for SH2D7 gene to outside databases

Previous GC identifers: GC15P076158 GC15P055142


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SH2D7 Gene:
SH2D7 (SH2 domain containing 7) is a protein-coding gene. An important paralog of this gene is SH2D4A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SH2D7 gene promoter:
         NF-1   NF-1/L   HEN1   RORalpha1   CBF-A   CBF-B   ARP-1   CP1A   NF-Y   CBF(2)   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SH2D7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.1   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q25.1

SH2D7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SH2D7 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P078370:  view genomic region     (about GC identifiers)

Start:
78,370,150 bp from pter      End:
78,397,251 bp from pter
Size:
27,102 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SH2D7_HUMAN, A6NKC9 (See protein sequence)
Recommended Name: SH2 domain-containing protein 7  
Size: 451 amino acids; 49807 Da

Explore the universe of human proteins at neXtProt for SH2D7: NX_A6NKC9

Explore proteomics data for SH2D7 at MOPED


See SH2D7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001094874.1  
ENSEMBL proteins: 
 ENSP00000386676   ENSP00000327846  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
SH2D: SH2 domain containing

1 InterPro protein domain:
 IPR000980 SH2

Graphical View of Domain Structure for InterPro Entry A6NKC9

ProtoNet protein and cluster: A6NKC9

UniProtKB/Swiss-Prot: SH2D7_HUMAN, A6NKC9
Similarity: Contains 1 SH2 domain


Find genes that share domains with SH2D7           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
Find genes that share ontologies with SH2D7           About GenesLikeMe


Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
nucleus3

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SH2D7
Interactions:

    Search GeneGlobe Interaction Network for SH2D7

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for SH2D7



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SH2D7 gene: 
NM_001101404.1  

Unigene Cluster for SH2D7:

SH2 domain containing 7
Hs.569511  [show with all ESTs]
Unigene Representative Sequence: NM_001101404
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000409568 ENST00000328828(uc010blb.1)
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1 DOTS entry:

DT.91710021 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SH2D7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CAATTGCTAC
SH2D7 Expression
About this image

SH2D7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SH2D7 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.569511
    Custom PCR Arrays for SH2D7
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH2D7

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for SH2D7 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Sh2d71 , 5 SH2 domain containing 71, 5 76.36(n)1
61.45(a)1
  9 (29.70 cM)5
2448851  NM_173778.31  NP_776139.11 
 545389845 
zebrafish
(Danio rerio)
Actinopterygii SH2D7 (2 of 2)6
SH2D7 (1 of 2)6
SH2 domain containing 7
3(a)
3(a)
1 ↔ many
1 ↔ many
14(8013701-8050675) ENSDARG00000029443
21(28141463-28188472) ENSDARG00000015557
worm
(Caenorhabditis elegans)
Secernentea F13B12.66
Protein F13B12.6 (F13B12.6) mRNA, complete cds
8(a)
1 → many
IV(10414072-10417881) WBGene00008733


ENSEMBL Gene Tree for SH2D7 (if available)
TreeFam Gene Tree for SH2D7 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SH2D7 gene
SH2D4A2  SH2D2A2  SH2D4B2  

Find genes that share paralogs with SH2D7           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SH2D7 (see all 305)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 15 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1495440161,2
C--78382966(+) ATCAC-/CATCATCA 1 -- us2k10--------
rs767886041,2
C--78382981(+) ATCATA/CATCAT 1 -- us2k10--------
rs1397850251,2
--78382984(+) ATCATA/CATCAT 1 -- us2k10--------
rs1452757671,2
--78382997(+) TCATCA/GTCATC 1 -- us2k10--------
rs711458941,2
C,F--78383006(+) CATCA-/TC/TC 
A
/TCATCA
AATTA
3 -- us2k1 cds12NA CSA 4
rs129034611,2
C,F,H--78383029(+) AGTCAC/TTATGT 1 -- us2k1 tfbs325Minor allele frequency- T:0.18NS EA NA WA CSA 2768
rs80398501,2
C,F,H--78383065(+) TAACTC/AATCTA 1 -- us2k1 tfbs330Minor allele frequency- A:0.21NS EA NA WA CSA 2627
rs1474587661,2
--78383268(+) AATCCA/GCACTC 1 -- us2k10--------
rs44382751,2
C,F,A,H--78383301(-) GTTCTA/GTTTCT 1 -- us2k124Minor allele frequency- G:0.21NS EA NA WA CSA 2181
rs1810542391,2
--78383427(+) ATGTTG/TCCCAG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for SH2D7 (78370150 - 78397251 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for SH2D7: --
Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SH2D7 gene integrated from 10 sources:
(articles sorted by number of sources associating them with SH2D7)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)1, 2 Zody M.C....Nusbaum C. (Nature 2006)
  2. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 646892 HGNC: 34549 Ensembl:ENSG00000183476 euGenes: HUgn646892 ECgene: SH2D7
H-InvDB: SH2D7

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SH2D7 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SH2D7 gene:
Search GeneIP for patents involving SH2D7

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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