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Aliases for SH2D7 Gene

Aliases for SH2D7 Gene

  • SH2 Domain Containing 7 2 3
  • Putative SH2 Domain-Containing Protein LOC646892 3
  • HCG38941 3

External Ids for SH2D7 Gene

Previous GeneCards Identifiers for SH2D7 Gene

  • GC15P076158
  • GC15P078370
  • GC15P055142

Summaries for SH2D7 Gene

GeneCards Summary for SH2D7 Gene

SH2D7 (SH2 Domain Containing 7) is a Protein Coding gene. An important paralog of this gene is SH2D4B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2D7 Gene

Genomics for SH2D7 Gene

Regulatory Elements for SH2D7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SH2D7 Gene

78,077,805 bp from pter
78,104,909 bp from pter
27,105 bases
Plus strand

Genomic View for SH2D7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for SH2D7 Gene

Proteins for SH2D7 Gene

  • Protein details for SH2D7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH2 domain-containing protein 7
    Protein Accession:

    Protein attributes for SH2D7 Gene

    451 amino acids
    Molecular mass:
    49807 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SH2D7 Gene

Proteomics data for SH2D7 Gene at MOPED

Post-translational modifications for SH2D7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH2D7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SH2D7 Gene

Domains & Families for SH2D7 Gene

Gene Families for SH2D7 Gene

Protein Domains for SH2D7 Gene


Suggested Antigen Peptide Sequences for SH2D7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SH2 domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SH2D7: view

Function for SH2D7 Gene

Phenotypes for SH2D7 Gene

GenomeRNAi human phenotypes for SH2D7:
genes like me logo Genes that share phenotypes with SH2D7: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SH2D7

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SH2D7 Gene

Localization for SH2D7 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SH2D7 Gene

Pathways & Interactions for SH2D7 Gene

SuperPathways for SH2D7 Gene

No Data Available

Interacting Proteins for SH2D7 Gene

Gene Ontology (GO) - Biological Process for SH2D7 Gene


No data available for Pathways by source and SIGNOR curated interactions for SH2D7 Gene

Drugs & Compounds for SH2D7 Gene

No Compound Related Data Available

Transcripts for SH2D7 Gene

mRNA/cDNA for SH2D7 Gene

(9) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SH2D7 Gene

SH2 domain containing 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SH2D7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D7 Gene

No ASD Table

Relevant External Links for SH2D7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH2D7 Gene

mRNA expression in normal human tissues for SH2D7 Gene

mRNA differential expression in normal tissues according to GTEx for SH2D7 Gene

This gene is overexpressed in Testis (x14.2), Colon - Transverse (x8.8), and Small Intestine - Terminal Ileum (x5.0).

Protein differential expression in normal tissues from HIPED for SH2D7 Gene

This gene is overexpressed in Adipocyte (61.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SH2D7 Gene

SOURCE GeneReport for Unigene cluster for SH2D7 Gene Hs.569511

genes like me logo Genes that share expression patterns with SH2D7: view

Protein tissue co-expression partners for SH2D7 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SH2D7 Gene

Orthologs for SH2D7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH2D7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SH2D7 35
  • 79.97 (n)
  • 75.12 (a)
SH2D7 36
  • 68 (a)
(Canis familiaris)
Mammalia SH2D7 35
  • 73.2 (n)
  • 55.78 (a)
SH2D7 36
  • 55 (a)
(Mus musculus)
Mammalia Sh2d7 35
  • 76.36 (n)
  • 61.45 (a)
Sh2d7 16
Sh2d7 36
  • 59 (a)
(Pan troglodytes)
Mammalia SH2D7 35
  • 90.17 (n)
  • 86.92 (a)
SH2D7 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Sh2d7 35
  • 76.54 (n)
  • 66.82 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
(Danio rerio)
Actinopterygii SH2D7 (1 of 2) 36
  • 3 (a)
SH2D7 (2 of 2) 36
  • 3 (a)
(Caenorhabditis elegans)
Secernentea F13B12.6 36
  • 8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 7 (a)
Species with no ortholog for SH2D7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SH2D7 Gene

Gene Tree for SH2D7 (if available)
Gene Tree for SH2D7 (if available)

Paralogs for SH2D7 Gene

Paralogs for SH2D7 Gene

genes like me logo Genes that share paralogs with SH2D7: view

Variants for SH2D7 Gene

Sequence variations from dbSNP and Humsavar for SH2D7 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs894298 -- 78,084,386(-) CTGTC(C/T)GAGCC intron-variant
rs2017959 -- 78,083,638(+) CTTTG(A/G)GAGGC intron-variant
rs2289524 - 78,098,072(-) TCAGC(A/G)TCTCT missense, reference
rs2289525 -- 78,097,626(-) ggtgc(A/G)aaatt intron-variant, utr-variant-5-prime
rs2867922 -- 78,099,627(-) TCCTT(C/T)GGCCA intron-variant

Variation tolerance for SH2D7 Gene

Residual Variation Intolerance Score: 94.74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH2D7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SH2D7 Gene

Disorders for SH2D7 Gene

Relevant External Links for SH2D7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SH2D7: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH2D7 Gene

Publications for SH2D7 Gene

  1. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 67
  2. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 67

Products for SH2D7 Gene

Sources for SH2D7 Gene

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