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Aliases for SH2D6 Gene

Aliases for SH2D6 Gene

  • SH2 Domain Containing 6 2 3 5

External Ids for SH2D6 Gene

Previous GeneCards Identifiers for SH2D6 Gene

  • GC02P085514
  • GC02P085518
  • GC02P085645
  • GC02P085559

Summaries for SH2D6 Gene

GeneCards Summary for SH2D6 Gene

SH2D6 (SH2 Domain Containing 6) is a Protein Coding gene. An important paralog of this gene is LCP2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2D6 Gene

Genomics for SH2D6 Gene

Regulatory Elements for SH2D6 Gene

Promoters for SH2D6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SH2D6 on UCSC Golden Path with GeneCards custom track

Genomic Location for SH2D6 Gene

85,418,721 bp from pter
85,437,029 bp from pter
18,309 bases
Plus strand

Genomic View for SH2D6 Gene

Genes around SH2D6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH2D6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH2D6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D6 Gene

Proteins for SH2D6 Gene

  • Protein details for SH2D6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH2 domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • A6ND14
    • Q6R306

    Protein attributes for SH2D6 Gene

    175 amino acids
    Molecular mass:
    19279 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SH2D6 Gene


neXtProt entry for SH2D6 Gene

Proteomics data for SH2D6 Gene at MOPED

Post-translational modifications for SH2D6 Gene

No Post-translational modifications

Other Protein References for SH2D6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SH2D6 Gene

Domains & Families for SH2D6 Gene

Gene Families for SH2D6 Gene

Protein Domains for SH2D6 Gene


Suggested Antigen Peptide Sequences for SH2D6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SH2 domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SH2D6: view

Function for SH2D6 Gene

Animal Model Products

CRISPR Products

miRNA for SH2D6 Gene

miRTarBase miRNAs that target SH2D6

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH2D6 Gene

Localization for SH2D6 Gene

Subcellular locations from

Jensen Localization Image for SH2D6 Gene COMPARTMENTS Subcellular localization image for SH2D6 gene
Compartment Confidence
nucleus 2
cytosol 1
extracellular 1
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SH2D6 Gene

Pathways & Interactions for SH2D6 Gene

SuperPathways for SH2D6 Gene

No Data Available

Interacting Proteins for SH2D6 Gene

Gene Ontology (GO) - Biological Process for SH2D6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IBA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
genes like me logo Genes that share ontologies with SH2D6: view

No data available for Pathways by source and SIGNOR curated interactions for SH2D6 Gene

Drugs & Compounds for SH2D6 Gene

No Compound Related Data Available

Transcripts for SH2D6 Gene

mRNA/cDNA for SH2D6 Gene

Unigene Clusters for SH2D6 Gene

SH2 domain containing 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - -
SP2: - -

Relevant External Links for SH2D6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH2D6 Gene

mRNA expression in normal human tissues for SH2D6 Gene

mRNA differential expression in normal tissues according to GTEx for SH2D6 Gene

This gene is overexpressed in Colon - Transverse (x9.2), Testis (x9.1), and Small Intestine - Terminal Ileum (x5.0).

SOURCE GeneReport for Unigene cluster for SH2D6 Gene Hs.209542

genes like me logo Genes that share expression patterns with SH2D6: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SH2D6 Gene

Orthologs for SH2D6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SH2D6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SH2D6 35
  • 82.21 (n)
  • 76.35 (a)
SH2D6 36
  • 40 (a)
(Canis familiaris)
Mammalia SH2D6 35
  • 85.13 (n)
  • 79.86 (a)
SH2D6 36
  • 65 (a)
(Mus musculus)
Mammalia Sh2d6 35
  • 82.85 (n)
  • 78.26 (a)
Sh2d6 16
Sh2d6 36
  • 36 (a)
(Pan troglodytes)
Mammalia SH2D6 35
  • 98.5 (n)
  • 97.3 (a)
SH2D6 36
  • 95 (a)
(Rattus norvegicus)
Mammalia LOC691161 35
  • 84.33 (n)
  • 82.84 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 8 (a)
(Ornithorhynchus anatinus)
Mammalia SH2D6 36
  • 48 (a)
(Gallus gallus)
Aves SLP76 36
  • 9 (a)
(Anolis carolinensis)
Reptilia SH2D6 36
  • 47 (a)
(Danio rerio)
Actinopterygii SH2D6 36
  • 37 (a)
Species with no ortholog for SH2D6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SH2D6 Gene

Gene Tree for SH2D6 (if available)
Gene Tree for SH2D6 (if available)

Paralogs for SH2D6 Gene

Paralogs for SH2D6 Gene

(1) SIMAP similar genes for SH2D6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SH2D6: view

Variants for SH2D6 Gene

Sequence variations from dbSNP and Humsavar for SH2D6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1515329 -- 85,421,082(+) GGGTA(G/T)AAGAC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1877954 -- 85,427,176(+) CCTGA(A/G)AAATT intron-variant
rs1877955 -- 85,427,403(+) GGCAG(C/G)CCTCT intron-variant
rs2271628 -- 85,434,894(-) CCTGG(C/T)AGGAC intron-variant, utr-variant-5-prime
rs4832173 -- 85,436,397(+) CCCAC(A/C)GTTGC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SH2D6 Gene

Variant ID Type Subtype PubMed ID
nsv834283 CNV Loss 17160897

Variation tolerance for SH2D6 Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH2D6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH2D6 Gene

Disorders for SH2D6 Gene

Relevant External Links for SH2D6

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SH2D6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH2D6 Gene

Publications for SH2D6 Gene

  1. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D. … Ferrucci L. (PLoS Genet. 2008) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for SH2D6 Gene

Sources for SH2D6 Gene

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