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Aliases for SH2D6 Gene

Aliases for SH2D6 Gene

  • SH2 Domain Containing 6 2 3 5

External Ids for SH2D6 Gene

Previous GeneCards Identifiers for SH2D6 Gene

  • GC02P085514
  • GC02P085518
  • GC02P085645
  • GC02P085559

Summaries for SH2D6 Gene

GeneCards Summary for SH2D6 Gene

SH2D6 (SH2 Domain Containing 6) is a Protein Coding gene. An important paralog of this gene is BLNK.

Additional gene information for SH2D6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2D6 Gene

Genomics for SH2D6 Gene

Regulatory Elements for SH2D6 Gene

Enhancers for SH2D6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H085430 1.2 Ensembl ENCODE dbSUPER 30.1 +12.5 12511 2 PKNOX1 MXI1 RFX1 MAFG SP2 ZNF398 BMI1 ZNF592 ZNF316 POLR2A SH2D6 CAPG GC02P085438
GH02H085428 1.3 Ensembl ENCODE dbSUPER 19.9 +9.9 9854 0 LEF1 KLF1 ATF1 BACH1 GATA2 EGR1 ATF7 L3MBTL2 SOX6 NR4A1 SH2D6 CAPG GC02P085438
GH02H085432 1.7 FANTOM5 ENCODE dbSUPER 15.1 +17.7 17690 7 SIN3A YY1 ZNF766 ELK1 ZNF143 ZNF207 RUNX3 SP3 REST ZNF592 SH2D6 MAT2A CAPG TGOLN2 KCMF1 ENSG00000207207 RNU7-64P
GH02H085536 1.7 FANTOM5 ENCODE dbSUPER 13.9 +121.0 121040 6 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A SNORD94 USP39 KDM3A TCF7L1 C2orf68 VAMP8 GGCX SH2D6 CAPG RNU7-64P
GH02H085497 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +81.2 81163 4 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF766 CBX5 ZNF143 USP39 SNORD94 MAT2A ELMOD3 LOC100996506 RNU7-64P RN7SL251P CAPG KDM3A C2orf68
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SH2D6 on UCSC Golden Path with GeneCards custom track

Promoters for SH2D6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000119566 -21 601 HDGF ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 ZNF207 ZNF143

Genomic Location for SH2D6 Gene

85,418,721 bp from pter
85,437,029 bp from pter
18,309 bases
Plus strand

Genomic View for SH2D6 Gene

Genes around SH2D6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH2D6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH2D6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D6 Gene

Proteins for SH2D6 Gene

  • Protein details for SH2D6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH2 domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • A6ND14
    • Q6R306

    Protein attributes for SH2D6 Gene

    175 amino acids
    Molecular mass:
    19279 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SH2D6 Gene


neXtProt entry for SH2D6 Gene

Post-translational modifications for SH2D6 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SH2D6 Gene

Domains & Families for SH2D6 Gene

Gene Families for SH2D6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SH2D6 Gene


Suggested Antigen Peptide Sequences for SH2D6 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SH2D6: view

No data available for UniProtKB/Swiss-Prot for SH2D6 Gene

Function for SH2D6 Gene

Phenotypes From GWAS Catalog for SH2D6 Gene

Gene Ontology (GO) - Molecular Function for SH2D6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity IBA --
GO:0005070 SH3/SH2 adaptor activity IBA --
genes like me logo Genes that share ontologies with SH2D6: view

Phenotypes for SH2D6 Gene

GenomeRNAi human phenotypes for SH2D6:
genes like me logo Genes that share phenotypes with SH2D6: view

Animal Model Products

CRISPR Products

miRNA for SH2D6 Gene

miRTarBase miRNAs that target SH2D6

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SH2D6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH2D6 Gene

Localization for SH2D6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH2D6 gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SH2D6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with SH2D6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for SH2D6 Gene

Pathways & Interactions for SH2D6 Gene

SuperPathways for SH2D6 Gene

No Data Available

Interacting Proteins for SH2D6 Gene

Selected Interacting proteins: Q7Z4S9-SH2D6_HUMAN for SH2D6 Gene via IID

Gene Ontology (GO) - Biological Process for SH2D6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IBA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA --
GO:0009967 positive regulation of signal transduction IEA --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with SH2D6: view

No data available for Pathways by source and SIGNOR curated interactions for SH2D6 Gene

Drugs & Compounds for SH2D6 Gene

No Compound Related Data Available

Transcripts for SH2D6 Gene

mRNA/cDNA for SH2D6 Gene

Unigene Clusters for SH2D6 Gene

SH2 domain containing 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SH2D6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - -
SP2: - -

Relevant External Links for SH2D6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH2D6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SH2D6 Gene

mRNA differential expression in normal tissues according to GTEx for SH2D6 Gene

This gene is overexpressed in Colon - Transverse (x9.2), Testis (x9.1), and Small Intestine - Terminal Ileum (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of SH2D6 Gene:


SOURCE GeneReport for Unigene cluster for SH2D6 Gene:

genes like me logo Genes that share expression patterns with SH2D6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SH2D6 Gene

Orthologs for SH2D6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SH2D6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SH2D6 33 34
  • 98.5 (n)
(Canis familiaris)
Mammalia SH2D6 33 34
  • 85.13 (n)
(Rattus norvegicus)
Mammalia LOC691161 33
  • 84.33 (n)
(Mus musculus)
Mammalia Sh2d6 33 16 34
  • 82.85 (n)
(Bos Taurus)
Mammalia SH2D6 33 34
  • 82.21 (n)
(Ornithorhynchus anatinus)
Mammalia SH2D6 34
  • 48 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 8 (a)
(Gallus gallus)
Aves SLP76 34
  • 9 (a)
(Anolis carolinensis)
Reptilia SH2D6 34
  • 47 (a)
(Danio rerio)
Actinopterygii SH2D6 34
  • 37 (a)
Species where no ortholog for SH2D6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SH2D6 Gene

Gene Tree for SH2D6 (if available)
Gene Tree for SH2D6 (if available)

Paralogs for SH2D6 Gene

Paralogs for SH2D6 Gene

(1) SIMAP similar genes for SH2D6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SH2D6: view

Variants for SH2D6 Gene

Sequence variations from dbSNP and Humsavar for SH2D6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000089229 -- 85,425,740(+) CCTGG(A/T)CACTG intron-variant, utr-variant-5-prime
rs1000308684 -- 85,432,691(+) CACCG(C/T)GCCCG intron-variant
rs1000524752 -- 85,425,269(+) TTTTT(C/T)TTTTT intron-variant, upstream-variant-2KB
rs1000539080 -- 85,420,821(+) CCCTC(C/T)TCACC intron-variant
rs1000556530 -- 85,420,492(+) CACCA(A/G)ACCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH2D6 Gene

Variant ID Type Subtype PubMed ID
nsv834283 CNV loss 17160897

Variation tolerance for SH2D6 Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH2D6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH2D6 Gene

Disorders for SH2D6 Gene

Relevant External Links for SH2D6

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SH2D6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH2D6 Gene

Publications for SH2D6 Gene

  1. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D … Ferrucci L (PLoS genetics 2008) 3 45 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 60

Products for SH2D6 Gene

Sources for SH2D6 Gene

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