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Aliases for SH2D6 Gene

Aliases for SH2D6 Gene

  • SH2 Domain Containing 6 2 3

External Ids for SH2D6 Gene

Previous GeneCards Identifiers for SH2D6 Gene

  • GC02P085514
  • GC02P085518
  • GC02P085645
  • GC02P085559

Summaries for SH2D6 Gene

GeneCards Summary for SH2D6 Gene

SH2D6 (SH2 Domain Containing 6) is a Protein Coding gene. An important paralog of this gene is LCP2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2D6 Gene

Genomics for SH2D6 Gene

Regulatory Elements for SH2D6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SH2D6 Gene

85,418,721 bp from pter
85,437,029 bp from pter
18,309 bases
Plus strand

Genomic View for SH2D6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SH2D6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D6 Gene

Proteins for SH2D6 Gene

  • Protein details for SH2D6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH2 domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • A6ND14
    • Q6R306

    Protein attributes for SH2D6 Gene

    175 amino acids
    Molecular mass:
    19279 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SH2D6 Gene


neXtProt entry for SH2D6 Gene

Proteomics data for SH2D6 Gene at MOPED

Post-translational modifications for SH2D6 Gene

No Post-translational modifications

Other Protein References for SH2D6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SH2D6 Gene

Domains for SH2D6 Gene

Gene Families for SH2D6 Gene

Protein Domains for SH2D6 Gene


Suggested Antigen Peptide Sequences for SH2D6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SH2 domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SH2D6: view

Function for SH2D6 Gene

Animal Model Products

CRISPR Products

miRNA for SH2D6 Gene

miRTarBase miRNAs that target SH2D6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SH2D6

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SH2D6 Gene

Localization for SH2D6 Gene

Subcellular locations from

Jensen Localization Image for SH2D6 Gene COMPARTMENTS Subcellular localization image for SH2D6 gene
Compartment Confidence
nucleus 2
cytosol 1
extracellular 1
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SH2D6 Gene

Pathways for SH2D6 Gene

SuperPathways for SH2D6 Gene

No Data Available

Interacting Proteins for SH2D6 Gene

Gene Ontology (GO) - Biological Process for SH2D6 Gene


No data available for Pathways by source for SH2D6 Gene

Transcripts for SH2D6 Gene

mRNA/cDNA for SH2D6 Gene

(29) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SH2D6 Gene

SH2 domain containing 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SH2D6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - -
SP2: - -

Relevant External Links for SH2D6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH2D6 Gene

mRNA expression in normal human tissues for SH2D6 Gene

mRNA differential expression in normal tissues according to GTEx for SH2D6 Gene

This gene is overexpressed in Colon - Transverse (9.2), Testis (9.1), and Small Intestine - Terminal Ileum (5.0).

SOURCE GeneReport for Unigene cluster for SH2D6 Gene Hs.209542

genes like me logo Genes that share expressions with SH2D6: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for SH2D6 Gene

Orthologs for SH2D6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SH2D6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SH2D6 35
  • 82.21 (n)
  • 76.35 (a)
SH2D6 36
  • 40 (a)
(Canis familiaris)
Mammalia SH2D6 35
  • 85.13 (n)
  • 79.86 (a)
SH2D6 36
  • 65 (a)
(Mus musculus)
Mammalia Sh2d6 35
  • 82.85 (n)
  • 78.26 (a)
Sh2d6 16
Sh2d6 36
  • 36 (a)
(Pan troglodytes)
Mammalia SH2D6 35
  • 98.5 (n)
  • 97.3 (a)
SH2D6 36
  • 95 (a)
(Rattus norvegicus)
Mammalia LOC691161 35
  • 84.33 (n)
  • 82.84 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 8 (a)
(Ornithorhynchus anatinus)
Mammalia SH2D6 36
  • 48 (a)
(Gallus gallus)
Aves SLP76 36
  • 9 (a)
(Anolis carolinensis)
Reptilia SH2D6 36
  • 47 (a)
(Danio rerio)
Actinopterygii SH2D6 36
  • 37 (a)
Species with no ortholog for SH2D6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SH2D6 Gene

Gene Tree for SH2D6 (if available)
Gene Tree for SH2D6 (if available)

Paralogs for SH2D6 Gene

Paralogs for SH2D6 Gene

(1) SIMAP similar genes for SH2D6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SH2D6: view

Variants for SH2D6 Gene

Sequence variations from dbSNP and Humsavar for SH2D6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2271628 -- 85,434,894(-) CCTGG(C/T)AGGAC utr-variant-5-prime, intron-variant
rs4832173 -- 85,436,397(+) CCCAC(A/C)GTTGC intron-variant
rs6547618 -- 85,435,527(+) TCTCC(A/G)AAACC intron-variant
rs7589663 -- 85,435,513(+) CGGAC(C/T)CCGGG intron-variant
rs7603717 -- 85,435,551(+) GGCTG(C/T)GGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH2D6 Gene

Variant ID Type Subtype PubMed ID
nsv834283 CNV Loss 17160897

Relevant External Links for SH2D6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH2D6 Gene

Disorders for SH2D6 Gene

Relevant External Links for SH2D6

Genetic Association Database (GAD)

No disorders were found for SH2D6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SH2D6 Gene

Publications for SH2D6 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D. … Ferrucci L. (PLoS Genet. 2008) 3 48
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for SH2D6 Gene

Sources for SH2D6 Gene

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