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Aliases for SH2D6 Gene

Aliases for SH2D6 Gene

  • SH2 Domain Containing 6 2 3

External Ids for SH2D6 Gene

Previous GeneCards Identifiers for SH2D6 Gene

  • GC02P085514
  • GC02P085518
  • GC02P085645
  • GC02P085559

Summaries for SH2D6 Gene

GeneCards Summary for SH2D6 Gene

SH2D6 (SH2 Domain Containing 6) is a Protein Coding gene. An important paralog of this gene is LCP2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2D6 Gene

Genomics for SH2D6 Gene

Regulatory Elements for SH2D6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SH2D6 Gene

Chromosome:
2
Start:
85,418,721 bp from pter
End:
85,437,029 bp from pter
Size:
18,309 bases
Orientation:
Plus strand

Genomic View for SH2D6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SH2D6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D6 Gene

Proteins for SH2D6 Gene

  • Protein details for SH2D6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4S9-SH2D6_HUMAN
    Recommended name:
    SH2 domain-containing protein 6
    Protein Accession:
    Q7Z4S9
    Secondary Accessions:
    • A6ND14
    • Q6R306

    Protein attributes for SH2D6 Gene

    Size:
    175 amino acids
    Molecular mass:
    19279 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SH2D6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH2D6 Gene

Proteomics data for SH2D6 Gene at MOPED

Post-translational modifications for SH2D6 Gene

No Post-translational modifications

Other Protein References for SH2D6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SH2D6 Gene

Domains & Families for SH2D6 Gene

Gene Families for SH2D6 Gene

Protein Domains for SH2D6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SH2D6 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z4S9

UniProtKB/Swiss-Prot:

SH2D6_HUMAN :
  • Contains 1 SH2 domain.
Domain:
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SH2D6: view

Function for SH2D6 Gene

Gene Ontology (GO) - Molecular Function for SH2D6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity IBA --
GO:0005070 SH3/SH2 adaptor activity IBA --
genes like me logo Genes that share ontologies with SH2D6: view

Animal Model Products

CRISPR Products

miRNA for SH2D6 Gene

miRTarBase miRNAs that target SH2D6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SH2D6

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for SH2D6 Gene

Localization for SH2D6 Gene

Gene Ontology (GO) - Cellular Components for SH2D6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with SH2D6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for SH2D6 Gene

Pathways & Interactions for SH2D6 Gene

SuperPathways for SH2D6 Gene

No Data Available

Interacting Proteins for SH2D6 Gene

Gene Ontology (GO) - Biological Process for SH2D6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IBA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0009967 positive regulation of signal transduction IBA --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with SH2D6: view

No data available for Pathways by source and SIGNOR curated interactions for SH2D6 Gene

Drugs & Compounds for SH2D6 Gene

No Compound Related Data Available

Transcripts for SH2D6 Gene

mRNA/cDNA for SH2D6 Gene

(29) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SH2D6 Gene

SH2 domain containing 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SH2D6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - -
SP2: - -
SP3:

Relevant External Links for SH2D6 Gene

GeneLoc Exon Structure for
SH2D6
ECgene alternative splicing isoforms for
SH2D6

Expression for SH2D6 Gene

mRNA expression in normal human tissues for SH2D6 Gene

mRNA differential expression in normal tissues according to GTEx for SH2D6 Gene

This gene is overexpressed in Colon - Transverse (x9.2), Testis (x9.1), and Small Intestine - Terminal Ileum (x5.0).

SOURCE GeneReport for Unigene cluster for SH2D6 Gene Hs.209542

genes like me logo Genes that share expression patterns with SH2D6: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SH2D6 Gene

Orthologs for SH2D6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SH2D6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SH2D6 35
  • 82.21 (n)
  • 76.35 (a)
SH2D6 36
  • 40 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SH2D6 35
  • 85.13 (n)
  • 79.86 (a)
SH2D6 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sh2d6 35
  • 82.85 (n)
  • 78.26 (a)
Sh2d6 16
Sh2d6 36
  • 36 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SH2D6 35
  • 98.5 (n)
  • 97.3 (a)
SH2D6 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC691161 35
  • 84.33 (n)
  • 82.84 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 8 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SH2D6 36
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLP76 36
  • 9 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia SH2D6 36
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii SH2D6 36
  • 37 (a)
OneToOne
Species with no ortholog for SH2D6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SH2D6 Gene

ENSEMBL:
Gene Tree for SH2D6 (if available)
TreeFam:
Gene Tree for SH2D6 (if available)

Paralogs for SH2D6 Gene

Paralogs for SH2D6 Gene

(1) SIMAP similar genes for SH2D6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SH2D6: view

Variants for SH2D6 Gene

Sequence variations from dbSNP and Humsavar for SH2D6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1515329 -- 85,421,082(+) GGGTA(G/T)AAGAC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1877954 -- 85,427,176(+) CCTGA(A/G)AAATT intron-variant
rs1877955 -- 85,427,403(+) GGCAG(C/G)CCTCT intron-variant
rs2271628 -- 85,434,894(-) CCTGG(C/T)AGGAC utr-variant-5-prime, intron-variant
rs4832173 -- 85,436,397(+) CCCAC(A/C)GTTGC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SH2D6 Gene

Variant ID Type Subtype PubMed ID
nsv834283 CNV Loss 17160897

Variation tolerance for SH2D6 Gene

Residual Variation Intolerance Score: 88.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH2D6 Gene

HapMap Linkage Disequilibrium report
SH2D6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH2D6 Gene

Disorders for SH2D6 Gene

Relevant External Links for SH2D6

Genetic Association Database (GAD)
SH2D6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SH2D6
genes like me logo Genes that share disorders with SH2D6: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH2D6 Gene

Publications for SH2D6 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D. … Ferrucci L. (PLoS Genet. 2008) 67
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 67
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for SH2D6 Gene

Sources for SH2D6 Gene

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