SH2D5 Gene
protein-coding GIFtS: 39
GCID: GC01M021046
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SH2 domain containing 5
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Aliases
for SH2D5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SH2 Domain Containing 51 2 | | SH2 Domain-Containing Protein 52 |
Export aliases for SH2D5 gene to outside databasesPrevious GC identifers: GC01M020792 GC01M020917 GC01M019291 |
Summaries
for SH2D5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SH2D5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SH2D5 gene promoter:
AML1a p53 Pax-6 Pax-2 Pax-2a AP-4 LCR-F1 Pax-2b LyF-1 ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for SH2D5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH2D5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.12 Ensembl cytogenetic band: 1p36.12 HGNC cytogenetic band: 1p36.12SH2D5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M021046: view genomic region
(about GC identifiers)
Start:
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21,046,225 bp from pter |
End:
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21,059,330 bp from pter |
Size:
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13,106 bases |
Orientation:
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minus strand |
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Proteins
for SH2D5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SH2D5_HUMAN, Q6ZV89 (See
protein sequence)Recommended Name: SH2 domain-containing protein 5 Size: 423 amino acids; 46797 Da
Sequence caution: Sequence=BAC85974.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=CAI23392.1; Type=Erroneous initiation;
Secondary accessions: B7Z3W3 Q5SSJ2Alternative splicing: 2 isoforms: Q6ZV89-1 Q6ZV89-2 Explore the universe of human proteins at neXtProt for SH2D5: NX_Q6ZV89
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZV89
SH2D5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001096630.1 NP_001096631.1
ENSEMBL proteins: ENSP00000364171 ENSP00000406026 ENSP00000408509 ENSP00000428153 ENSP00000428656 ENSP00000430115
Human Recombinant Protein Products:
SH2D5 Antibody Products:
Assay Products for SH2D5: |
Protein
Domains /
Families
for SH2D5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SH2D5 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6ZV89ProtoNet protein and cluster: Q6ZV89 UniProtKB/Swiss-Prot: SH2D5_HUMAN, Q6ZV89Similarity: Contains 1 SH2 domain |
Function
for SH2D5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH2D5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH2D5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): SH2D5 (NM_001103161) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SH2D5 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SH2D5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH2D5 |
|
Pathways & Interactions
for SH2D5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SH2D5
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for SH2D5 (Q6ZV892, 3 ENSP000004085094) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for SH2D5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SH2D5
Search CenterWatch for drugs/clinical trials and news about SH2D5
|
Transcripts
for SH2D5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SH2D5 gene (2 alternative transcripts): NM_001103160.1 NM_001103161.1 Unigene Cluster for SH2D5: SH2 domain containing 5 Hs.591522 [show with all ESTs]Unigene Representative Sequence: NM_0011031617 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000375031(uc009vpy.1 uc001bdt.1) ENST00000460804(uc001bdu.1)
ENST00000444387 ENST00000447746 ENST00000518294 ENST00000517430 ENST00000519434
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH2D5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH2D5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SH2D5 (NM_001103161) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SH2D5 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SH2D5 |
Additional cDNA sequence: AK057535.1 AK123236.1 AK123841.1 AK124869.1 AK296431.1 3 DOTS entries: DT.97818687 DT.205711 DT.121444249 24/43 AceView cDNA sequences (see all 43): BM845027 BM844979 BM842001 AI937119 BM761379 CF527842 BM759141 AA921798 AK123841 AW297884 BM761131 BU162571 AW205004 AK123236 T95861 BI752841 AA978133 BM844615 BM842298 BM796462 BF926719 AA824394 AI149054 BX118738
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for SH2D5 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
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| SP1: | | | | | - | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SH2D5
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Expression
for SH2D5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SH2D5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTTAATCAG
About this image
See SH2D5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SH2D5
SOURCE GeneReport for Unigene cluster: Hs.591522
SABiosciences Custom PCR Arrays for SH2D5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SH2D5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SH2D5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SH2D5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SH2D5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH2D5 |
Orthologs
for SH2D5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SH2D5 gene from 3/8 species (see all 8) About this table
ENSEMBL Gene Tree for SH2D5 (if available)
TreeFam Gene Tree for SH2D5 (if available) |
Paralogs
for SH2D5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SH2D5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SH2D5 (21046225 - 21059330 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SH2D5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SH2D5 |
|
Disorders
/ Diseases
for SH2D5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SH2D5 for disorders About MalaCards
SH2D5 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: SH2D5 (1 document)
Export disorders for SH2D5 gene to outside databases
|
Publications
for SH2D5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SH2D5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SH2D5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
|
External Searches for SH2D5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SH2D5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SH2D5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SH2D5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SH2D5 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SH2D5 gene:
Search GeneIP for patents involving SH2D5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SH2D5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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 | | | SH2D5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH2D5 |
|  |  |  | | | | Search ThermoFisher Antibodies for SH2D5 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SH2D5 |
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