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Aliases for SH2D5 Gene

Aliases for SH2D5 Gene

  • SH2 Domain Containing 5 2 3 5

External Ids for SH2D5 Gene

Previous GeneCards Identifiers for SH2D5 Gene

  • GC01M020917
  • GC01M021046
  • GC01M019291

Summaries for SH2D5 Gene

GeneCards Summary for SH2D5 Gene

SH2D5 (SH2 Domain Containing 5) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SH2D5 Gene

  • May be involved in synaptic plasticity regulation through the control of Rac-GTP levels.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2D5 Gene

Genomics for SH2D5 Gene

Regulatory Elements for SH2D5 Gene

Enhancers for SH2D5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G020784 1.2 ENCODE 10.9 -54.0 -54031 4.2 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ENSG00000233069 SH2D5 EIF4G3 HP1BP3 GC01P020738
GH01G020683 0.8 Ensembl ENCODE 11.1 +47.7 47709 2.6 ZNF362 ZSCAN4 MAX HNRNPL NR2F2 ZBTB20 EGR2 PINK1 ENSG00000233069 SH2D5 UBXN10-AS1 EIF4G3 ENSG00000235432 DDOST
GH01G020932 0.8 ENCODE 10.5 -199.8 -199757 1.1 BCOR ZMYM3 EBF1 ZNF121 ZNF316 ARID3A EED ETV6 RELB IKZF2 HP1BP3 EIF4G3 SH2D5 ENSG00000233069 LOC105376829 MIR1256
GH01G020678 0.7 Ensembl 11.1 +53.9 53937 0.6 TBL1XR1 RELA FOXK2 EED PRDM10 ETV6 RELB IKZF2 MTA2 CBFB PINK1 ENSG00000233069 SH2D5 CDA MUL1 DDOST ENSG00000235432
GH01G020730 1.1 ENCODE 5 +0.5 533 4.2 PKNOX1 MLX AGO1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 ZNF143 HP1BP3 EIF4G3 SH2D5 KIF17
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SH2D5 on UCSC Golden Path with GeneCards custom track

Promoters for SH2D5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000002656 837 801 AGO1 ARID4B ZNF2 TCF12 ZNF121 GLIS2 ZNF766 GATA2 ZNF143 ZNF263

Genomic Location for SH2D5 Gene

20,719,731 bp from pter
20,732,837 bp from pter
13,107 bases
Minus strand

Genomic View for SH2D5 Gene

Genes around SH2D5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH2D5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH2D5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D5 Gene

Proteins for SH2D5 Gene

  • Protein details for SH2D5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH2 domain-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • B7Z3W3
    • Q5SSJ2

    Protein attributes for SH2D5 Gene

    423 amino acids
    Molecular mass:
    46797 Da
    Quaternary structure:
    • Interacts with BCR.
    • Sequence=BAC85974.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI23392.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SH2D5 Gene


neXtProt entry for SH2D5 Gene

Post-translational modifications for SH2D5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SH2D5 Gene

Domains & Families for SH2D5 Gene

Protein Domains for SH2D5 Gene


Suggested Antigen Peptide Sequences for SH2D5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SH2D5: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SH2D5 Gene

Function for SH2D5 Gene

Molecular function for SH2D5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in synaptic plasticity regulation through the control of Rac-GTP levels.

Phenotypes for SH2D5 Gene

MGI mutant phenotypes for SH2D5:
inferred from 1 alleles
GenomeRNAi human phenotypes for SH2D5:
genes like me logo Genes that share phenotypes with SH2D5: view

Animal Models for SH2D5 Gene

MGI Knock Outs for SH2D5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SH2D5 Gene

Localization for SH2D5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH2D5 Gene

Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH2D5 gene
Compartment Confidence
plasma membrane 3
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SH2D5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014069 postsynaptic density ISS --
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
GO:0045202 synapse IEA --
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with SH2D5: view

Pathways & Interactions for SH2D5 Gene

SuperPathways for SH2D5 Gene

No Data Available

Interacting Proteins for SH2D5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q6ZV89-SH2D5_HUMAN ENSP00000406026 for SH2D5 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SH2D5 Gene


No data available for Pathways by source and SIGNOR curated interactions for SH2D5 Gene

Drugs & Compounds for SH2D5 Gene

(1) Drugs for SH2D5 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 2018
genes like me logo Genes that share compounds with SH2D5: view

Transcripts for SH2D5 Gene

Unigene Clusters for SH2D5 Gene

SH2 domain containing 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP3: -

Relevant External Links for SH2D5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH2D5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SH2D5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH2D5 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x8.4), Brain - Cortex (x7.3), Brain - Putamen (basal ganglia) (x6.2), Brain - Frontal Cortex (BA9) (x5.8), Brain - Caudate (basal ganglia) (x5.7), and Brain - Anterior cingulate cortex (BA24) (x4.8).

Protein differential expression in normal tissues from HIPED for SH2D5 Gene

This gene is overexpressed in Placenta (55.8) and Frontal cortex (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SH2D5 Gene

Protein tissue co-expression partners for SH2D5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SH2D5 Gene:


SOURCE GeneReport for Unigene cluster for SH2D5 Gene:


Evidence on tissue expression from TISSUES for SH2D5 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SH2D5: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SH2D5 Gene

Orthologs for SH2D5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SH2D5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SH2D5 34 35
  • 97.97 (n)
(Canis familiaris)
Mammalia SH2D5 34 35
  • 89.05 (n)
(Bos Taurus)
Mammalia SH2D5 34 35
  • 88.42 (n)
(Mus musculus)
Mammalia Sh2d5 34 16 35
  • 84.95 (n)
(Rattus norvegicus)
Mammalia Sh2d5 34
  • 84.95 (n)
(Monodelphis domestica)
Mammalia SH2D5 35
  • 67 (a)
(Gallus gallus)
Aves SH2D5 34 35
  • 67.56 (n)
(Danio rerio)
Actinopterygii sh2d5 34 35
  • 53.82 (n)
Species where no ortholog for SH2D5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SH2D5 Gene

Gene Tree for SH2D5 (if available)
Gene Tree for SH2D5 (if available)

Paralogs for SH2D5 Gene

No data available for Paralogs for SH2D5 Gene

Variants for SH2D5 Gene

Sequence variations from dbSNP and Humsavar for SH2D5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000069532 -- 20,731,308(+) TCGGG(A/C)AAACC intron-variant, utr-variant-5-prime
rs1000131132 -- 20,731,232(+) GAGGG(G/T)CTGGG intron-variant, utr-variant-5-prime
rs1000184567 -- 20,724,033(+) CGCAC(-/GG)GGGCA intron-variant
rs1000236633 -- 20,726,166(+) CCAGG(A/C)CCGCC intron-variant
rs1000294533 -- 20,731,646(+) GGGGG(A/T)GCTGC intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SH2D5 Gene

Variant ID Type Subtype PubMed ID
nsv520013 CNV loss 19592680
nsv545731 CNV gain 21841781
nsv834369 CNV loss 17160897

Variation tolerance for SH2D5 Gene

Residual Variation Intolerance Score: 58.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH2D5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH2D5 Gene

Disorders for SH2D5 Gene

Relevant External Links for SH2D5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SH2D5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH2D5 Gene

Publications for SH2D5 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. src homology 2 domain containing protein 5 (sh2d5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1- GTP. (PMID: 25331951) Gray E.J. … Pawson T. (J. Biol. Chem. 2014) 4 64
  5. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PMID: 21706016) Bisson N. … Pawson T. (Nat. Biotechnol. 2011) 3 64

Products for SH2D5 Gene

Sources for SH2D5 Gene

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