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Aliases for SH2D5 Gene

Aliases for SH2D5 Gene

  • SH2 Domain Containing 5 2 3

External Ids for SH2D5 Gene

Previous GeneCards Identifiers for SH2D5 Gene

  • GC01M020917
  • GC01M021046
  • GC01M019291

Summaries for SH2D5 Gene

GeneCards Summary for SH2D5 Gene

SH2D5 (SH2 Domain Containing 5) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SH2D5 Gene

  • May be involved in synaptic plasticity regulation through the control of Rac-GTP levels.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2D5 Gene

Genomics for SH2D5 Gene

Regulatory Elements for SH2D5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SH2D5 Gene

20,719,732 bp from pter
20,732,837 bp from pter
13,106 bases
Minus strand

Genomic View for SH2D5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SH2D5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D5 Gene

Proteins for SH2D5 Gene

  • Protein details for SH2D5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH2 domain-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • B7Z3W3
    • Q5SSJ2

    Protein attributes for SH2D5 Gene

    423 amino acids
    Molecular mass:
    46797 Da
    Quaternary structure:
    • Interacts with BCR.
    • Sequence=BAC85974.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI23392.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SH2D5 Gene


neXtProt entry for SH2D5 Gene

Proteomics data for SH2D5 Gene at MOPED

Post-translational modifications for SH2D5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH2D5 Gene

No data available for DME Specific Peptides for SH2D5 Gene

Domains for SH2D5 Gene

Protein Domains for SH2D5 Gene


Suggested Antigen Peptide Sequences for SH2D5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6ZV89
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SH2D5: view

No data available for Gene Families for SH2D5 Gene

Function for SH2D5 Gene

Molecular function for SH2D5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in synaptic plasticity regulation through the control of Rac-GTP levels.

Gene Ontology (GO) - Molecular Function for SH2D5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SH2D5: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SH2D5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SH2D5 Gene

Localization for SH2D5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH2D5 Gene

Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.

Subcellular locations from

Jensen Localization Image for SH2D5 Gene COMPARTMENTS Subcellular localization image for SH2D5 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SH2D5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014069 postsynaptic density ISS --
GO:0030054 cell junction IEA --
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with SH2D5: view

Pathways for SH2D5 Gene

SuperPathways for SH2D5 Gene

No Data Available

Interacting Proteins for SH2D5 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q6ZV89-SH2D5_HUMAN ENSP00000406026 for SH2D5 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for SH2D5 Gene


No data available for Pathways by source for SH2D5 Gene

Transcripts for SH2D5 Gene

Unigene Clusters for SH2D5 Gene

SH2 domain containing 5:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SH2D5

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP3: -

Relevant External Links for SH2D5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH2D5 Gene

mRNA expression in normal human tissues for SH2D5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH2D5 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (8.4), Brain - Cortex (7.3), Brain - Putamen (basal ganglia) (6.2), Brain - Frontal Cortex (BA9) (5.8), Brain - Caudate (basal ganglia) (5.7), and Brain - Anterior cingulate cortex (BA24) (4.8).

Protein differential expression in normal tissues for SH2D5 Gene

This gene is overexpressed in Placenta (55.8) and Frontal cortex (13.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SH2D5 Gene

SOURCE GeneReport for Unigene cluster for SH2D5 Gene Hs.591522

genes like me logo Genes that share expressions with SH2D5: view

Expression partners for SH2D5 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SH2D5 Gene

Orthologs for SH2D5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SH2D5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SH2D5 35
  • 88.42 (n)
  • 91.02 (a)
SH2D5 36
  • 90 (a)
(Canis familiaris)
Mammalia SH2D5 35
  • 89.05 (n)
  • 92.43 (a)
SH2D5 36
  • 91 (a)
(Mus musculus)
Mammalia Sh2d5 35
  • 84.95 (n)
  • 88.42 (a)
Sh2d5 16
Sh2d5 36
  • 86 (a)
(Pan troglodytes)
Mammalia SH2D5 35
  • 97.97 (n)
  • 97.8 (a)
SH2D5 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Sh2d5 35
  • 84.95 (n)
  • 88.42 (a)
(Monodelphis domestica)
Mammalia SH2D5 36
  • 67 (a)
(Gallus gallus)
Aves SH2D5 35
  • 67.56 (n)
  • 58.4 (a)
SH2D5 36
  • 57 (a)
(Danio rerio)
Actinopterygii sh2d5 35
  • 53.82 (n)
  • 45.41 (a)
sh2d5 36
  • 35 (a)
Species with no ortholog for SH2D5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SH2D5 Gene

Gene Tree for SH2D5 (if available)
Gene Tree for SH2D5 (if available)

Paralogs for SH2D5 Gene

No data available for Paralogs for SH2D5 Gene

Variants for SH2D5 Gene

Sequence variations from dbSNP and Humsavar for SH2D5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs531044 -- 20,730,518(+) CCACC(C/T)ACCAT intron-variant
rs592060 -- 20,724,465(-) GATCA(A/G)CTCTC synonymous-codon, reference
rs609880 -- 20,729,398(-) GCTGG(C/T)CCAAA intron-variant
rs637990 -- 20,721,123(-) GGATG(C/T)GCACC utr-variant-3-prime
rs646786 -- 20,728,233(+) AGCCC(A/G)GAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH2D5 Gene

Variant ID Type Subtype PubMed ID
nsv834369 CNV Loss 17160897
nsv870827 CNV Gain 21882294
nsv520013 CNV Loss 19592680
nsv870993 CNV Loss 21882294
dgv188n71 CNV Loss 21882294

Relevant External Links for SH2D5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH2D5 Gene

Disorders for SH2D5 Gene

Relevant External Links for SH2D5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for SH2D5 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SH2D5 Gene

Publications for SH2D5 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. A quantitative protein interaction network for the ErbB receptors using protein microarrays. (PMID: 16273093) Jones R.B. … MacBeath G. (Nature 2006) 3
  5. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PMID: 21706016) Bisson N. … Pawson T. (Nat. Biotechnol. 2011) 3

Products for SH2D5 Gene

Sources for SH2D5 Gene

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