Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SH2D5 Gene

Aliases for SH2D5 Gene

  • SH2 Domain Containing 5 2 3 5

External Ids for SH2D5 Gene

Previous GeneCards Identifiers for SH2D5 Gene

  • GC01M020917
  • GC01M021046
  • GC01M019291

Summaries for SH2D5 Gene

GeneCards Summary for SH2D5 Gene

SH2D5 (SH2 Domain Containing 5) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SH2D5 Gene

  • May be involved in synaptic plasticity regulation through the control of Rac-GTP levels.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2D5 Gene

Genomics for SH2D5 Gene

Regulatory Elements for SH2D5 Gene

Enhancers for SH2D5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SH2D5 on UCSC Golden Path with GeneCards custom track

Promoters for SH2D5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SH2D5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SH2D5 Gene

Chromosome:
1
Start:
20,719,731 bp from pter
End:
20,732,837 bp from pter
Size:
13,107 bases
Orientation:
Minus strand

Genomic View for SH2D5 Gene

Genes around SH2D5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH2D5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH2D5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D5 Gene

Proteins for SH2D5 Gene

  • Protein details for SH2D5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZV89-SH2D5_HUMAN
    Recommended name:
    SH2 domain-containing protein 5
    Protein Accession:
    Q6ZV89
    Secondary Accessions:
    • B7Z3W3
    • Q5SSJ2

    Protein attributes for SH2D5 Gene

    Size:
    423 amino acids
    Molecular mass:
    46797 Da
    Quaternary structure:
    • Interacts with BCR.
    SequenceCaution:
    • Sequence=BAC85974.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI23392.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SH2D5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH2D5 Gene

Proteomics data for SH2D5 Gene at MOPED

Post-translational modifications for SH2D5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH2D5 Gene

No data available for DME Specific Peptides for SH2D5 Gene

Domains & Families for SH2D5 Gene

Protein Domains for SH2D5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SH2D5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZV89

UniProtKB/Swiss-Prot:

SH2D5_HUMAN :
  • Contains 1 SH2 domain.
Domain:
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SH2D5: view

No data available for Gene Families for SH2D5 Gene

Function for SH2D5 Gene

Molecular function for SH2D5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in synaptic plasticity regulation through the control of Rac-GTP levels.

Phenotypes for SH2D5 Gene

MGI mutant phenotypes for SH2D5:
inferred from 1 alleles
GenomeRNAi human phenotypes for SH2D5:
genes like me logo Genes that share phenotypes with SH2D5: view

Animal Models for SH2D5 Gene

MGI Knock Outs for SH2D5:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SH2D5 Gene

Localization for SH2D5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH2D5 Gene

Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SH2D5 Gene COMPARTMENTS Subcellular localization image for SH2D5 gene
Compartment Confidence
cytosol 3
plasma membrane 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SH2D5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014069 postsynaptic density ISS --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with SH2D5: view

Pathways & Interactions for SH2D5 Gene

SuperPathways for SH2D5 Gene

No Data Available

Interacting Proteins for SH2D5 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000406026%0d%0a9606.ENSP00000339007%0d%0a9606.ENSP00000269571%0d%0a
Selected Interacting proteins: Q6ZV89-SH2D5_HUMAN ENSP00000406026 for SH2D5 Gene via MINT I2D STRING

Gene Ontology (GO) - Biological Process for SH2D5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SH2D5 Gene

Drugs & Compounds for SH2D5 Gene

(1) Drugs for SH2D5 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 1898
genes like me logo Genes that share compounds with SH2D5: view

Transcripts for SH2D5 Gene

Unigene Clusters for SH2D5 Gene

SH2 domain containing 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2:
SP3: -

Relevant External Links for SH2D5 Gene

GeneLoc Exon Structure for
SH2D5
ECgene alternative splicing isoforms for
SH2D5

Expression for SH2D5 Gene

mRNA expression in normal human tissues for SH2D5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH2D5 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x8.4), Brain - Cortex (x7.3), Brain - Putamen (basal ganglia) (x6.2), Brain - Frontal Cortex (BA9) (x5.8), Brain - Caudate (basal ganglia) (x5.7), and Brain - Anterior cingulate cortex (BA24) (x4.8).

Protein differential expression in normal tissues from HIPED for SH2D5 Gene

This gene is overexpressed in Placenta (55.8) and Frontal cortex (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SH2D5 Gene



SOURCE GeneReport for Unigene cluster for SH2D5 Gene Hs.591522

genes like me logo Genes that share expression patterns with SH2D5: view

Protein tissue co-expression partners for SH2D5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SH2D5 Gene

Orthologs for SH2D5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SH2D5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SH2D5 35
  • 88.42 (n)
  • 91.02 (a)
SH2D5 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SH2D5 35
  • 89.05 (n)
  • 92.43 (a)
SH2D5 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sh2d5 35
  • 84.95 (n)
  • 88.42 (a)
Sh2d5 16
Sh2d5 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SH2D5 35
  • 97.97 (n)
  • 97.8 (a)
SH2D5 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sh2d5 35
  • 84.95 (n)
  • 88.42 (a)
oppossum
(Monodelphis domestica)
Mammalia SH2D5 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves SH2D5 35
  • 67.56 (n)
  • 58.4 (a)
SH2D5 36
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sh2d5 35
  • 53.82 (n)
  • 45.41 (a)
sh2d5 36
  • 35 (a)
OneToOne
Species with no ortholog for SH2D5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SH2D5 Gene

ENSEMBL:
Gene Tree for SH2D5 (if available)
TreeFam:
Gene Tree for SH2D5 (if available)

Paralogs for SH2D5 Gene

No data available for Paralogs for SH2D5 Gene

Variants for SH2D5 Gene

Sequence variations from dbSNP and Humsavar for SH2D5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs531044 -- 20,730,518(+) CCACC(C/T)ACCAT intron-variant
rs592060 -- 20,724,465(-) GATCA(A/G)CTCTC reference, synonymous-codon
rs637990 -- 20,721,123(-) GGATG(C/T)GCACC utr-variant-3-prime
rs609880 -- 20,729,398(-) GCTGG(C/T)CCAAA intron-variant
rs671905 -- 20,720,599(-) AACTC(A/T)GTTAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SH2D5 Gene

Variant ID Type Subtype PubMed ID
nsv834369 CNV Loss 17160897
nsv870827 CNV Gain 21882294
nsv520013 CNV Loss 19592680
nsv870993 CNV Loss 21882294
dgv188n71 CNV Loss 21882294

Variation tolerance for SH2D5 Gene

Residual Variation Intolerance Score: 58.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH2D5 Gene

HapMap Linkage Disequilibrium report
SH2D5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH2D5 Gene

Disorders for SH2D5 Gene

Relevant External Links for SH2D5

Genetic Association Database (GAD)
SH2D5
Human Genome Epidemiology (HuGE) Navigator
SH2D5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SH2D5

No disorders were found for SH2D5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH2D5 Gene

Publications for SH2D5 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PMID: 21706016) Bisson N. … Pawson T. (Nat. Biotechnol. 2011) 3
  3. A quantitative protein interaction network for the ErbB receptors using protein microarrays. (PMID: 16273093) Jones R.B. … MacBeath G. (Nature 2006) 3
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for SH2D5 Gene

Sources for SH2D5 Gene

Content