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Aliases for SH2D4B Gene

Aliases for SH2D4B Gene

  • SH2 Domain Containing 4B 2 3 5

External Ids for SH2D4B Gene

Previous GeneCards Identifiers for SH2D4B Gene

  • GC10P081962
  • GC10P082287
  • GC10P076140
  • GC10P082297
  • GC10P080634
  • GC10P080676
  • GC10P080679
  • GC10P080692
  • GC10P080831
  • GC10P080914

Summaries for SH2D4B Gene

GeneCards Summary for SH2D4B Gene

SH2D4B (SH2 Domain Containing 4B) is a Protein Coding gene. Diseases associated with SH2D4B include Lymphocytic Vasculitis. An important paralog of this gene is SH2D4A.

Additional gene information for SH2D4B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2D4B Gene

Genomics for SH2D4B Gene

Regulatory Elements for SH2D4B Gene

Enhancers for SH2D4B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H080660 0.8 FANTOM5 Ensembl 17.7 +122.9 122903 0 CTCF PKNOX1 SH2D4B TMEM254 ANXA11 LOC105378386 GC10M080717
GH10H080528 1.4 FANTOM5 Ensembl ENCODE dbSUPER 7.6 -8.5 -8502 2 CTCF GLIS1 SMC3 ZIC2 RAD21 SH2D4B LOC101929574 ANXA11 TSPAN14 PIR63069 PIR41876
GH10H080192 1.9 FANTOM5 ENCODE dbSUPER 5.1 -336.6 -336625 16 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 MBL1P LOC642361 ENSG00000235858 LINC00857 ENSG00000272489 MAT1A ANXA11 DYDC2 PLAC9 SH2D4B
GH10H080539 0.5 FANTOM5 18.9 +1.9 1939 0 HDGF ZNF687 ZIC2 SH2D4B ANXA11 LOC105378387
GH10H080597 1 Ensembl ENCODE 8.6 +60.6 60599 1 CTCF PKNOX1 EBF1 BATF EED ATF7 RUNX3 IKZF2 SMARCA5 ZNF687 SH2D4B EIF5AP4 LOC105378387
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SH2D4B on UCSC Golden Path with GeneCards custom track

Genomic Location for SH2D4B Gene

Chromosome:
10
Start:
80,537,902 bp from pter
End:
80,646,560 bp from pter
Size:
108,659 bases
Orientation:
Plus strand

Genomic View for SH2D4B Gene

Genes around SH2D4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH2D4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH2D4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D4B Gene

Proteins for SH2D4B Gene

  • Protein details for SH2D4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SQS7-SH24B_HUMAN
    Recommended name:
    SH2 domain-containing protein 4B
    Protein Accession:
    Q5SQS7
    Secondary Accessions:
    • Q5SQS5
    • Q6ZVW9
    • Q6ZVZ3

    Protein attributes for SH2D4B Gene

    Size:
    431 amino acids
    Molecular mass:
    51232 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SH2D4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH2D4B Gene

Post-translational modifications for SH2D4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH2D4B Gene

No data available for DME Specific Peptides for SH2D4B Gene

Domains & Families for SH2D4B Gene

Gene Families for SH2D4B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SH2D4B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SH2D4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SH2D4B: view

No data available for UniProtKB/Swiss-Prot for SH2D4B Gene

Function for SH2D4B Gene

Phenotypes From GWAS Catalog for SH2D4B Gene

genes like me logo Genes that share phenotypes with SH2D4B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SH2D4B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SH2D4B Gene

Localization for SH2D4B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH2D4B gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SH2D4B Gene

Pathways & Interactions for SH2D4B Gene

SuperPathways for SH2D4B Gene

No Data Available

Interacting Proteins for SH2D4B Gene

Selected Interacting proteins: Q5SQS7-SH24B_HUMAN for SH2D4B Gene via IID

Gene Ontology (GO) - Biological Process for SH2D4B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SH2D4B Gene

Drugs & Compounds for SH2D4B Gene

(4) Drugs for SH2D4B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for SH2D4B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SH2D4B: view

Transcripts for SH2D4B Gene

mRNA/cDNA for SH2D4B Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SH2D4B Gene

SH2 domain containing 4B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SH2D4B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D4B Gene

No ASD Table

Relevant External Links for SH2D4B Gene

GeneLoc Exon Structure for
SH2D4B
ECgene alternative splicing isoforms for
SH2D4B

Expression for SH2D4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SH2D4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH2D4B Gene

This gene is overexpressed in Testis (x8.1) and Whole Blood (x5.9).

NURSA nuclear receptor signaling pathways regulating expression of SH2D4B Gene:

SH2D4B

SOURCE GeneReport for Unigene cluster for SH2D4B Gene:

Hs.147643
genes like me logo Genes that share expression patterns with SH2D4B: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SH2D4B Gene

Orthologs for SH2D4B Gene

This gene was present in the common ancestor of animals.

Orthologs for SH2D4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SH2D4B 33 34
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia SH2D4B 33 34
  • 91.5 (n)
dog
(Canis familiaris)
Mammalia SH2D4B 33 34
  • 90.48 (n)
mouse
(Mus musculus)
Mammalia Sh2d4b 33 16 34
  • 85.77 (n)
rat
(Rattus norvegicus)
Mammalia Sh2d4b 33
  • 85.57 (n)
oppossum
(Monodelphis domestica)
Mammalia SH2D4B 34
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SH2D4B 34
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves SH2D4B 33 34
  • 68.4 (n)
lizard
(Anolis carolinensis)
Reptilia SH2D4B 34
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sh2d4b 33
  • 64.29 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100330227 33
  • 63.14 (n)
SH2D4B (1 of 2) 34
  • 43 (a)
OneToMany
sh2d4b 34
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F13B12.6 34
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 17 (a)
OneToMany
Species where no ortholog for SH2D4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH2D4B Gene

ENSEMBL:
Gene Tree for SH2D4B (if available)
TreeFam:
Gene Tree for SH2D4B (if available)

Paralogs for SH2D4B Gene

Paralogs for SH2D4B Gene

(1) SIMAP similar genes for SH2D4B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SH2D4B: view

Variants for SH2D4B Gene

Sequence variations from dbSNP and Humsavar for SH2D4B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000006326 -- 80,573,560(+) CAGTA(G/T)TCCCC intron-variant
rs1000019902 -- 80,592,096(+) TGTGA(A/C)GTGAC intron-variant
rs1000068690 -- 80,596,508(+) ACTCT(C/T)GGCCT intron-variant
rs1000081878 -- 80,586,967(+) GCCAG(C/T)GAGAC intron-variant
rs1000187285 -- 80,614,128(+) TCCAG(-/GT)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH2D4B Gene

Variant ID Type Subtype PubMed ID
esv1010104 CNV insertion 20482838
esv2669158 CNV deletion 23128226
esv2761609 CNV loss 21179565
esv3305386 CNV mobile element insertion 20981092
esv3390706 CNV insertion 20981092
esv3578993 CNV loss 25503493
esv3584622 CNV loss 24956385
esv3623952 CNV loss 21293372
nsv1042808 CNV gain 25217958
nsv1048827 CNV gain 25217958
nsv1141879 OTHER inversion 24896259
nsv469837 CNV loss 16826518
nsv469860 CNV gain+loss 16826518
nsv470967 CNV loss 18288195
nsv7354 CNV deletion 18451855
nsv831924 CNV loss 17160897

Variation tolerance for SH2D4B Gene

Residual Variation Intolerance Score: 88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.70; 93.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH2D4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SH2D4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH2D4B Gene

Disorders for SH2D4B Gene

MalaCards: The human disease database

(1) MalaCards diseases for SH2D4B Gene - From: GeneCards

Disorder Aliases PubMed IDs
lymphocytic vasculitis
  • vasculitis lymphocytic, nodular
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SH2D4B

Genetic Association Database (GAD)
SH2D4B
Human Genome Epidemiology (HuGE) Navigator
SH2D4B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SH2D4B
genes like me logo Genes that share disorders with SH2D4B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SH2D4B Gene

Publications for SH2D4B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Identification of novel germline polymorphisms governing capecitabine sensitivity. (PMID: 22864933) O'Donnell PH … Dolan ME (Cancer 2012) 3 60
  4. Identification of key cytosolic kinases containing evolutionarily conserved kinase tyrosine-based inhibitory motifs (KTIMs). (PMID: 20043942) Abu-Dayyeh I … Olivier M (Developmental and comparative immunology 2010) 22 60
  5. O-linked N-acetylglucosamine modification of insulin receptor substrate-1 occurs in close proximity to multiple SH2 domain binding motifs. (PMID: 19671924) Klein AL … Ball LE (Molecular & cellular proteomics : MCP 2009) 22 60

Products for SH2D4B Gene

Sources for SH2D4B Gene

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