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Aliases for SH2D4B Gene

Aliases for SH2D4B Gene

  • SH2 Domain Containing 4B 2 3 5

External Ids for SH2D4B Gene

Previous GeneCards Identifiers for SH2D4B Gene

  • GC10P081962
  • GC10P082287
  • GC10P076140
  • GC10P082297
  • GC10P080634
  • GC10P080676
  • GC10P080679

Summaries for SH2D4B Gene

GeneCards Summary for SH2D4B Gene

SH2D4B (SH2 Domain Containing 4B) is a Protein Coding gene. Diseases associated with SH2D4B include Lymphocytic Vasculitis. An important paralog of this gene is SH2D4A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2D4B Gene

Genomics for SH2D4B Gene

Regulatory Elements for SH2D4B Gene

Enhancers for SH2D4B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SH2D4B on UCSC Golden Path with GeneCards custom track

Genomic Location for SH2D4B Gene

80,537,902 bp from pter
80,646,560 bp from pter
108,659 bases
Plus strand

Genomic View for SH2D4B Gene

Genes around SH2D4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH2D4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH2D4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D4B Gene

Proteins for SH2D4B Gene

  • Protein details for SH2D4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH2 domain-containing protein 4B
    Protein Accession:
    Secondary Accessions:
    • Q5SQS5
    • Q6ZVW9
    • Q6ZVZ3

    Protein attributes for SH2D4B Gene

    431 amino acids
    Molecular mass:
    51232 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SH2D4B Gene


neXtProt entry for SH2D4B Gene

Post-translational modifications for SH2D4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH2D4B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SH2D4B Gene

Domains & Families for SH2D4B Gene

Gene Families for SH2D4B Gene

Protein Domains for SH2D4B Gene


Suggested Antigen Peptide Sequences for SH2D4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SH2 domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SH2D4B: view

Function for SH2D4B Gene

genes like me logo Genes that share phenotypes with SH2D4B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SH2D4B Gene

Localization for SH2D4B Gene

Subcellular locations from

Jensen Localization Image for SH2D4B Gene COMPARTMENTS Subcellular localization image for SH2D4B gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SH2D4B Gene

Pathways & Interactions for SH2D4B Gene

SuperPathways for SH2D4B Gene

No Data Available

Interacting Proteins for SH2D4B Gene

Selected Interacting proteins: Q5SQS7-SH24B_HUMAN for SH2D4B Gene via IID

Gene Ontology (GO) - Biological Process for SH2D4B Gene


No data available for Pathways by source and SIGNOR curated interactions for SH2D4B Gene

Drugs & Compounds for SH2D4B Gene

(4) Drugs for SH2D4B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for SH2D4B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SH2D4B: view

Transcripts for SH2D4B Gene

mRNA/cDNA for SH2D4B Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SH2D4B Gene

SH2 domain containing 4B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D4B Gene

No ASD Table

Relevant External Links for SH2D4B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH2D4B Gene

mRNA expression in normal human tissues for SH2D4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH2D4B Gene

This gene is overexpressed in Testis (x8.1) and Whole Blood (x5.9).

NURSA nuclear receptor signaling pathways regulating expression of SH2D4B Gene:


SOURCE GeneReport for Unigene cluster for SH2D4B Gene:

genes like me logo Genes that share expression patterns with SH2D4B: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SH2D4B Gene

Orthologs for SH2D4B Gene

This gene was present in the common ancestor of animals.

Orthologs for SH2D4B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SH2D4B 34
  • 91.5 (n)
  • 93 (a)
SH2D4B 35
  • 67 (a)
(Canis familiaris)
Mammalia SH2D4B 34
  • 90.48 (n)
  • 93.28 (a)
SH2D4B 35
  • 74 (a)
(Mus musculus)
Mammalia Sh2d4b 34
  • 85.77 (n)
  • 90.85 (a)
Sh2d4b 16
Sh2d4b 35
  • 71 (a)
(Pan troglodytes)
Mammalia SH2D4B 34
  • 99.35 (n)
  • 98.88 (a)
SH2D4B 35
  • 77 (a)
(Rattus norvegicus)
Mammalia Sh2d4b 34
  • 85.57 (n)
  • 91.16 (a)
(Monodelphis domestica)
Mammalia SH2D4B 35
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia SH2D4B 35
  • 54 (a)
(Gallus gallus)
Aves SH2D4B 34
  • 68.4 (n)
  • 69.33 (a)
SH2D4B 35
  • 56 (a)
(Anolis carolinensis)
Reptilia SH2D4B 35
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sh2d4b 34
  • 64.29 (n)
  • 66.15 (a)
(Danio rerio)
Actinopterygii LOC100330227 34
  • 63.14 (n)
  • 60.9 (a)
sh2d4b 35
  • 42 (a)
SH2D4B (1 of 2) 35
  • 43 (a)
(Caenorhabditis elegans)
Secernentea F13B12.6 35
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 17 (a)
Species where no ortholog for SH2D4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH2D4B Gene

Gene Tree for SH2D4B (if available)
Gene Tree for SH2D4B (if available)

Paralogs for SH2D4B Gene

Paralogs for SH2D4B Gene

(1) SIMAP similar genes for SH2D4B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SH2D4B: view

Variants for SH2D4B Gene

Sequence variations from dbSNP and Humsavar for SH2D4B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs7075840 - 80,603,648(+) CCGAC(A/G)CCACT reference, missense
rs11817391 - 80,603,654(+) CCACT(C/G/T)GCTCC reference, missense
rs1913756 -- 80,585,255(-) AGGGA(C/G)AGGTG intron-variant
rs1913757 -- 80,585,091(-) CTTCT(A/G)CCTTT intron-variant
rs1913758 -- 80,585,041(-) ATGAA(A/C)CACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH2D4B Gene

Variant ID Type Subtype PubMed ID
esv1010104 CNV insertion 20482838
esv2669158 CNV deletion 23128226
esv2761609 CNV loss 21179565
esv3305386 CNV mobile element insertion 20981092
esv3390706 CNV insertion 20981092
esv3578993 CNV loss 25503493
esv3584622 CNV loss 24956385
esv3623952 CNV loss 21293372
nsv1042808 CNV gain 25217958
nsv1048827 CNV gain 25217958
nsv1141879 OTHER inversion 24896259
nsv469837 CNV loss 16826518
nsv469860 CNV gain+loss 16826518
nsv470967 CNV loss 18288195
nsv7354 CNV deletion 18451855
nsv831924 CNV loss 17160897

Variation tolerance for SH2D4B Gene

Residual Variation Intolerance Score: 88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.70; 93.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH2D4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH2D4B Gene

Disorders for SH2D4B Gene

MalaCards: The human disease database

(1) MalaCards diseases for SH2D4B Gene - From: GeneCards

Disorder Aliases PubMed IDs
lymphocytic vasculitis
  • vasculitis lymphocytic, nodular
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SH2D4B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SH2D4B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SH2D4B Gene

Publications for SH2D4B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. Identification of novel germline polymorphisms governing capecitabine sensitivity. (PMID: 22864933) O'Donnell P.H. … Dolan M.E. (Cancer 2012) 3 65
  4. Identification of key cytosolic kinases containing evolutionarily conserved kinase tyrosine-based inhibitory motifs (KTIMs). (PMID: 20043942) Abu-Dayyeh I. … Olivier M. (Dev. Comp. Immunol. 2010) 22 65
  5. O-linked N-acetylglucosamine modification of insulin receptor substrate-1 occurs in close proximity to multiple SH2 domain binding motifs. (PMID: 19671924) Klein A.L. … Ball L.E. (Mol. Cell Proteomics 2009) 22 65

Products for SH2D4B Gene

Sources for SH2D4B Gene

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