Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SH2D4B Gene

protein-coding   GIFtS: 45
GCID: GC10P082297

SH2 Domain Containing 4B

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
SH2 Domain Containing 4B1 2
Novel SH2 Domain-Containing Protein2
SH2 Domain-Containing Protein 4B2

External Ids:    HGNC: 314401   Entrez Gene: 3876942   Ensembl: ENSG000001782177   UniProtKB: Q5SQS73   

Export aliases for SH2D4B gene to outside databases

Previous GC identifers: GC10P081962 GC10P082287 GC10P076140


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SH2D4B Gene:
SH2D4B (SH2 domain containing 4B) is a protein-coding gene. Diseases associated with SH2D4B include lymphocytic vasculitis, and vasculitis. An important paralog of this gene is SH2D7.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the SH2D4B gene promoter:
         FOXC1   AML1a   NRSF form 1   LHX3a/Lhx3a   IRF-1   NRSF form 2   Ik-3   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSH2D4B promoter sequence
   Search Chromatin IP Primers for SH2D4B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SH2D4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.1   Ensembl cytogenetic band:  10q23.1   HGNC cytogenetic band: 10q23.1

SH2D4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SH2D4B gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P082297:  view genomic region     (about GC identifiers)

Start:
82,297,658 bp from pter      End:
82,406,316 bp from pter
Size:
108,659 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SH24B_HUMAN, Q5SQS7 (See protein sequence)
Recommended Name: SH2 domain-containing protein 4B  
Size: 431 amino acids; 51232 Da
Secondary accessions: Q5SQS5 Q6ZVW9 Q6ZVZ3
Alternative splicing: 3 isoforms:  Q5SQS7-1   Q5SQS7-2   Q5SQS7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SH2D4B: NX_Q5SQS7

Explore proteomics data for SH2D4B at MOPED


See SH2D4B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001139191.1  NP_997255.2  

ENSEMBL proteins: 
 ENSP00000345295   ENSP00000417953   ENSP00000314242  

SH2D4B Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for SH2D4B
OriGene Custom MassSpec
OriGene Custom Protein Services for SH2D4B
GenScript Custom Purified and Recombinant Proteins Services for SH2D4B
Novus Biologicals SH2D4B Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for SH2D4B

SH2D4B Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for SH2D4B
Novus Biologicals SH2D4B Antibody
Abcam antibodies for SH2D4B
Cloud-Clone Corp. Antibodies for SH2D4B
Search ThermoFisher Antibodies for SH2D4B
LSBio Antibodies in human, mouse, rat for SH2D4B

SH2D4B Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for SH2D4B
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for SH2D4B
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for SH2D4B
Cloud-Clone Corp. CLIAs for SH2D4B


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
SH2D: SH2 domain containing

1 InterPro protein domain:
 IPR000980 SH2

Graphical View of Domain Structure for InterPro Entry Q5SQS7

ProtoNet protein and cluster: Q5SQS7

1 Blocks protein domain: IPB000980 SH2 domain signature

UniProtKB/Swiss-Prot: SH24B_HUMAN, Q5SQS7
Similarity: Contains 1 SH2 domain


SH2D4B for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
SH2D4B for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for SH2D4B:
 Decreased TP53 protein express 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SH2D4B
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SH2D4B

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SH2D4B
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SH2D4B

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat SH2D4B using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate SH2D4B (see all 36):
hsa-miR-549 hsa-miR-579 hsa-miR-3152-3p hsa-miR-607 hsa-miR-4328 hsa-miR-4272 hsa-miR-1258 hsa-miR-624
SwitchGear 3'UTR luciferase reporter plasmidSH2D4B 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for SH2D4B
Predesigned siRNA for gene silencing in human, mouse, rat SH2D4B

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for SH2D4B

Clone
Products:
     
OriGene clones in human, mouse for SH2D4B (see all 13)
OriGene ORF clones in mouse, rat for SH2D4B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): SH2D4B (NM_001145719)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SH2D4B
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SH2D4B

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for SH2D4B
Browse ESI BIO Cell Lines and PureStem Progenitors for SH2D4B 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH2D4B


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus



    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SH2D4B
Interactions:

    Search GeneGlobe Interaction Network for SH2D4B

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SH2D4B (SH24B)

6 Novoseek inferred chemical compound relationships for SH2D4B gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
phosphotyrosine 73 6 10926366 (1), 11258422 (1), 11851339 (1), 10525402 (1)
tyrosine 69.8 18 8811072 (1), 9751747 (1), 7535767 (1), 9671493 (1) (see all 17)
phosphatidylinositol 62.8 4 10926366 (1), 11384880 (1), 9261155 (1)
inositol 19 2 9111325 (1)
calcium 0 1 8107887 (1)
serine 0 1 10358153 (1)



SH2D4B for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for SH2D4B gene (2 alternative transcripts): 
NM_001145719.1  NM_207372.2  

Unigene Cluster for SH2D4B:

SH2 domain containing 4B
Hs.147643  [show with all ESTs]
Unigene Representative Sequence: AK123885
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000339284(uc001kck.1) ENST00000372150 ENST00000481537(uc001kcn.1)
ENST00000470604 ENST00000313455(uc001kcl.1 uc001kcm.1)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat SH2D4B using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate SH2D4B (see all 36):
hsa-miR-549 hsa-miR-579 hsa-miR-3152-3p hsa-miR-607 hsa-miR-4328 hsa-miR-4272 hsa-miR-1258 hsa-miR-624
SwitchGear 3'UTR luciferase reporter plasmidSH2D4B 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for SH2D4B
Predesigned siRNA for gene silencing in human, mouse, rat SH2D4B
Clone
Products:
     
OriGene clones in human, mouse for SH2D4B (see all 13)
OriGene ORF clones in mouse, rat for SH2D4B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): SH2D4B (NM_001145719)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SH2D4B
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SH2D4B
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for SH2D4B
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SH2D4B
  QuantiTect SYBR Green Assays in human, mouse, rat SH2D4B
  QuantiFast Probe-based Assays in human, mouse, rat SH2D4B

Additional mRNA sequence: 

AK091518.1 AK123885.1 AK123978.1 

3 DOTS entries:

DT.101977821  DT.99938567  DT.101966547 

6 AceView cDNA sequences:

AK123885 NM_207372 AK123978 AX747036 AX776201 AK091518 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

SH2D4B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TCTCATATAT
SH2D4B Expression
About this image


SH2D4B expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Thymus (Hematopoietic System)
         Thymus
SH2D4B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SH2D4B Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.147643
    Custom PCR Arrays for SH2D4B
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for SH2D4B
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SH2D4B
QuantiTect SYBR Green Assays in human, mouse, rat SH2D4B
QuantiFast Probe-based Assays in human, mouse, rat SH2D4B
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH2D4B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for SH2D4B gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Sh2d4b1 , 5 SH2 domain containing 4B1, 5 85.77(n)1
90.85(a)1
  14 (22.36 cM)5
3283811  NM_177816.31  NP_808484.21 
 408137895 
chicken
(Gallus gallus)
Aves SH2D4B1 SH2 domain containing 4B 68.4(n)
69.33(a)
  769640  XM_001232927.2  XP_001232928.2 
lizard
(Anolis carolinensis)
Reptilia SH2D4B6
SH2 domain containing 4B
52(a)
1 ↔ 1
GL343233.1(2192465-2332987)
tropical clawed frog
(Xenopus tropicalis)
Amphibia sh2d4b1 SH2 domain containing 4B 64.29(n)
66.15(a)
  100496838  XM_002933901.2  XP_002933947.2 
zebrafish
(Danio rerio)
Actinopterygii LOC1003302271 SH2 domain containing 4A-like 63.14(n)
60.9(a)
  100330227  XM_002664174.3  XP_002664220.3 
worm
(Caenorhabditis elegans)
Secernentea F13B12.66
Protein F13B12.6 (F13B12.6) mRNA, complete cds
17(a)
1 → many
IV(10414072-10417881) WBGene00008733


ENSEMBL Gene Tree for SH2D4B (if available)
TreeFam Gene Tree for SH2D4B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for SH2D4B gene
SH2D72  SH2D4A2  SH2D2A2  
1 SIMAP similar gene for SH2D4B using alignment to 2 protein entries:     SH24B_HUMAN (see all proteins):
SH2D4A

SH2D4B for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for SH2D4B (see all 2623)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1122374911,2
C--82295672(+) TGCTCT/CTCGGC 1 -- us2k12Minor allele frequency- C:0.05CSA WA 119
rs2015475211,2
--82295690(+) TGCTC-/CTGG  
  GGTCCT
CTGGG
1 -- us2k10--------
rs1822676571,2
--82295706(+) CTGGGA/GTCCTC 1 -- us2k10--------
rs1442457731,2
--82295805(+) TGGCCA/GAGTCC 1 -- us2k10--------
rs1873599921,2
--82295843(+) AGAATG/TGATAG 1 -- us2k10--------
rs1170116861,2
F--82295846(+) ATTGAT/CAGGCG 1 -- us2k11Minor allele frequency- C:0.07NA 120
rs741431681,2
C,F--82295855(+) CGGGCC/TCCGAA 1 -- us2k13Minor allele frequency- T:0.14WA NA 240
rs1997047251,2
C--82295870(+) GTCTT-/CCCGGA 1 -- us2k10--------
rs733071031,2
C,F--82296028(+) AATGGG/ACGCTA 1 -- us2k12Minor allele frequency- A:0.07WA 120
rs1465619431,2
C--82296056(+) CCGGCC/TGCCTC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for SH2D4B (82297658 - 82406316 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for SH2D4B:    About this table    
Variant IDTypeSubtypePubMed ID
esv2738807CNV Deletion23290073
esv2669158CNV Deletion23128226
esv269663CNV Insertion20981092
esv1010104CNV Insertion20482838
nsv470967CNV Loss18288195
nsv7354CNV Loss18451855
nsv469837CNV Loss16826518
nsv831924CNV Loss17160897
nsv469860CNV Complex16826518

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SH2D4B
DNA2.0 Custom Variant and Variant Library Synthesis for SH2D4B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
7 diseases for SH2D4B:    
About MalaCards
lymphocytic vasculitis    vasculitis    gout    b-cell lymphomas
lymphoblastic leukemia    leukemia    breast cancer


SH2D4B for disorders           About GeneDecksing

1 Novoseek inferred disease relationship for SH2D4B gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia 0 1 16636677 (1)

Genetic Association Database (GAD): SH2D4B
Human Genome Epidemiology (HuGE) Navigator: SH2D4B (1 document)

Export disorders for SH2D4B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for SH2D4B gene, integrated from 10 sources (see all 79):
(articles sorted by number of sources associating them with SH2D4B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. Identification of novel germline polymorphisms governing capecitabine sensitivity. (PubMed id 22864933)1 O'Donnell P.H....Dolan M.E. (Cancer 2012)
  4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (Nature 2004)
  5. Molecular recognition by SH2 domains. (PubMed id 12461824)9 Bradshaw J.M. and Waksman G. (Adv. Protein Chem. 2002)
  6. Characterization of the roles of SH2 domain-containing proteins in T-lymphocyte activation by using dominant negative SH2 domains. (PubMed id 8628292)9 Northrop J.P....Grove J.R. (Mol. Cell. Biol. 1996)
  7. X-linked lymphoproliferative disease: genetics and biochemistry. (PubMed id 11258422)9 Nichols K.E. (Rev Immunogenet 2000)
  8. Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP. (PubMed id 9367831)9 Pesesse X.... Erneux C. (Biochem. Biophys. Res. Commun. 1997)
  9. Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins. (PubMed id 7760813)9 Neumeister E.N....Shaw A.S. (Mol. Cell. Biol. 1995)
  10. Identification of key cytosolic kinases containing evolutionarily conserved kinase tyrosine-based inhibitory motifs (KTIMs). (PubMed id 20043942)9 Abu-Dayyeh I....Olivier M. (Dev. Comp. Immunol. 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 387694 HGNC: 31440 AceView: SH2D4B Ensembl:ENSG00000178217 euGenes: HUgn387694
ECgene: SH2D4B H-InvDB: SH2D4B

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for SH2D4B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for SH2D4B gene:
Search GeneIP for patents involving SH2D4B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SH2D4B  
 Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SH2D4B  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for SH2D4B  
 OriGene qSTAR qPCR primer pairs in human, mouse for SH2D4B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for SH2D4B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for SH2D4B   OriGene Custom Protein Services for SH2D4B  

 
 
 Block miRNA regulation of human, mouse, rat SH2D4B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SH2D4B
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SH2D4B Predesigned siRNA for gene silencing in human, mouse, rat SH2D4B
 QuantiFast Probe-based Assays in human, mouse, rat SH2D4B QuantiTect SYBR Green Assays in human, mouse, rat SH2D4B
 Custom PCR Arrays for SH2D4B Search Chromatin IP Primers for SH2D4B
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SH2D4B  Search GeneGlobe Interaction Network for SH2D4B
 Regulatory tfbs in SH2D4B promoter
 GenScript Custom Purified and Recombinant Proteins Services for SH2D4B GenScript cDNA clones with any tag delivered in your preferred vector for SH2D4B
 GenScript Custom Assay Services for SH2D4B GenScript Custom overexpressing Cell Line Services for SH2D4B
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for SH2D4B (SH24B)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 SH2D4B antibodies
 SH2D4B lysates
 Antibodies for SH2D4B
 See all of Abcam's Antibodies, Kits and Proteins for SH2D4B
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for SH2D4B
 Antibodies for SH2D4B
 ELISAs for SH2D4B
 CLIAs for SH2D4B



 Browse ESI BIO Cell Lines and PureStem Progenitors for SH2D4B
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH2D4B
 SwitchGear 3'UTR luciferase reporter plasmids for SH2D4B
 SwitchGear Promoter luciferase reporter plasmids for SH2D4B
 Search ThermoFisher Antibodies for SH2D4B
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SH2D4B
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SH2D4B
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SH2D4B
 LSBio Antibodies in human, mouse, rat for SH2D4B
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      SH2D4B gene at Home site.
Version: 3.12.166 28 Aug 2014
hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4