SH2D4B Gene
protein-coding GIFtS: 43
GCID: GC10P082297
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SH2 domain containing 4B
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Aliases
for SH2D4B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SH2 Domain Containing 4B1 2 | | Novel SH2 Domain-Containing Protein2 | | SH2 Domain-Containing Protein 4B2 |
Export aliases for SH2D4B gene to outside databasesPrevious GC identifers: GC10P081962 GC10P082287 GC10P076140 |
Summaries
for SH2D4B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SH2D4B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SH2D4B gene promoter:
FOXC1 AML1a NRSF form 1 LHX3a/Lhx3a IRF-1 NRSF form 2 Ik-3 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for SH2D4B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH2D4B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q23.1 Ensembl cytogenetic band: 10q23.1 HGNC cytogenetic band: 10q23.1SH2D4B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P082297: view genomic region
(about GC identifiers)
Start:
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82,297,658 bp from pter |
End:
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82,406,316 bp from pter |
Size:
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108,659 bases |
Orientation:
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plus strand |
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Proteins
for SH2D4B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SH24B_HUMAN, Q5SQS7 (See
protein sequence)Recommended Name: SH2 domain-containing protein 4B Size: 431 amino acids; 51232 Da
Secondary accessions: Q5SQS5 Q6ZVW9 Q6ZVZ3Alternative splicing: 3 isoforms: Q5SQS7-1 Q5SQS7-2 Q5SQS7-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SH2D4B: NX_Q5SQS7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5SQS7
SH2D4B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001139191.1 NP_997255.2
ENSEMBL proteins: ENSP00000345295 ENSP00000361220 ENSP00000417953 ENSP00000314242
Human Recombinant Protein Products:
SH2D4B Antibody Products:
Assay Products for SH2D4B: |
Protein
Domains /
Families
for SH2D4B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SH2D4B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5SQS7ProtoNet protein and cluster: Q5SQS7 1 Blocks protein family: IPB000980 SH2 domain signature
UniProtKB/Swiss-Prot: SH24B_HUMAN, Q5SQS7Similarity: Contains 1 SH2 domain |
Function
for SH2D4B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH2D4B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH2D4B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): SH2D4B (NM_001145719) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SH2D4B | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SH2D4B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH2D4B |
1 GenomeRNAi human phenotype for SH2D4B:
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Pathways & Interactions
for SH2D4B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SH2D4B
|
Drugs & Compounds
for SH2D4B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SH2D4B for compounds About GeneDecksing
 Browse Tocris compounds for SH2D4B
6 Novoseek chemical compound relationships for SH2D4B gene About this table
Search CenterWatch for drugs/clinical trials and news about SH2D4B / SH24B
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Transcripts
for SH2D4B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SH2D4B gene (2 alternative transcripts): NM_001145719.1 NM_207372.2 Unigene Cluster for SH2D4B: SH2 domain containing 4B Hs.147643 [show with all ESTs]Unigene Representative Sequence: AK1238856 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000339284(uc001kck.1) ENST00000372147 ENST00000470604 ENST00000372150
ENST00000481537(uc001kcn.1) ENST00000313455(uc001kcl.1 uc001kcm.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH2D4B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH2D4B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SH2D4B (NM_001145719) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SH2D4B | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SH2D4B |
Additional cDNA sequence: AK091518.1 AK123885.1 AK123978.1 3 DOTS entries: DT.101977821 DT.99938567 DT.101966547 6 AceView cDNA sequences: AK123885 NM_207372 AX776201 AX747036 AK091518 AK123978
GeneLoc Exon Structure
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Expression
for SH2D4B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SH2D4B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTCATATAT
About this image
See SH2D4B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SH2D4B
SOURCE GeneReport for Unigene cluster: Hs.147643
SABiosciences Custom PCR Arrays for SH2D4B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SH2D4B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SH2D4B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SH2D4B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SH2D4B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH2D4B |
Orthologs
for SH2D4B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for SH2D4B gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for SH2D4B (if available)
TreeFam Gene Tree for SH2D4B (if available) |
Paralogs
for SH2D4B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SH2D4B gene
- SH2D4A2 HSH2D2 SH2D2A2
1 SIMAP similar gene for SH2D4B using alignment to 2 protein entries: SH24B_HUMAN (see all proteins):SH2D4A
SH2D4B for paralogs About GeneDecksing
|
Genomic Variants
for SH2D4B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for SH2D4B (82297658 - 82406316 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SH2D4B
3 CNVs: 2161 0762 2160 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SH2D4B |
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Disorders
/ Diseases
for SH2D4B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SH2D4B for disorders About GeneDecksing
8  diseases for SH2D4B: About MalaCardsb-cell lymphomas lymphocytic vasculitis metabolic disorders vasculitis
lymphoblastic leukemia gout leukemia breast cancer
1 Novoseek disease relationship for SH2D4B gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leukemia |
0 |
1 |
16636677 (1) |
Human Genome Epidemiology (HuGE) Navigator: SH2D4B (1 document)
Export disorders for SH2D4B gene to outside databases
|
Publications
for SH2D4B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SH2D4B gene, integrated from 9 sources (see all 79):
(articles sorted by number of sources associating them with SH2D4B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Identification of novel germline polymorphisms governi ng capecitabine sensitivity. (PubMed id 22864933)1 O'Donnell P.H....Dolan M.E. (2012)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
- Molecular recognition by SH2 domains. (PubMed id 12461824)9 Bradshaw J.M. and Waksman G. (2002)
- Characterization of the roles of SH2 domain-containing proteins in T-lymphocyte activation by using dominant negative SH2 domains. (PubMed id 8628292)9 Northrop J.P....Grove J.R. (1996)
- X-linked lymphoproliferative disease: genetics and biochemistry. (PubMed id 11258422)9 Nichols K.E. (2000)
- Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP. (PubMed id 9367831)9 Pesesse X.... Erneux C. (1997)
- Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins. (PubMed id 7760813)9 Neumeister E.N....Shaw A.S. (1995)
- Identification of key cytosolic kinases containing ev olutionarily conserved kinase tyrosine-based inhibitory motifs (KTIMs). (PubMed id 20043942)9 Abu-Dayyeh I....Olivier M. (2010)
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External Searches for SH2D4B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SH2D4B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing SH2D4B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SH2D4B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SH2D4B | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SH2D4B gene:
Search GeneIP for patents involving SH2D4B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SH2D4B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SH2D4B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SH2D4B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SH2D4B | | | OriGene Protein Over-expression Lysate for SH2D4B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SH2D4B | | OriGene 3'-UTR Clone for SH2D4B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH2D4B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH2D4B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SH2D4B | | OriGene Custom Protein Services for SH2D4B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SH2D4B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SH2D4B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH2D4B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SH2D4B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SH2D4B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SH2D4B |
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| | | | Search Tocris compounds for SH2D4B |
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 | | | SH2D4B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH2D4B |
|  |  |  | | | | Search ThermoFisher Antibodies for SH2D4B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SH2D4B |
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