Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SH2D4A Gene

Aliases for SH2D4A Gene

  • SH2 Domain Containing 4A 2 3
  • PPP1R38 3 4 6
  • SH2A 3 4 6
  • Protein Phosphatase 1 Regulatory Subunit 38 3 4
  • Protein SH(2)A 3 4
  • Protein Phosphatase 1, Regulatory Subunit 38 3
  • SH2 Domain-Containing Protein 4A 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 38 2

External Ids for SH2D4A Gene

Previous GeneCards Identifiers for SH2D4A Gene

  • GC08P019182
  • GC08P019215
  • GC08P017711

Summaries for SH2D4A Gene

GeneCards Summary for SH2D4A Gene

SH2D4A (SH2 Domain Containing 4A) is a Protein Coding gene. GO annotations related to this gene include phosphatase binding. An important paralog of this gene is SH2D4B.

UniProtKB/Swiss-Prot for SH2D4A Gene

  • Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function.

Gene Wiki entry for SH2D4A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2D4A Gene

Genomics for SH2D4A Gene

Regulatory Elements for SH2D4A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SH2D4A Gene

Start:
19,313,570 bp from pter
End:
19,396,218 bp from pter
Size:
82,649 bases
Orientation:
Plus strand

Genomic View for SH2D4A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SH2D4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D4A Gene

Proteins for SH2D4A Gene

  • Protein details for SH2D4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H788-SH24A_HUMAN
    Recommended name:
    SH2 domain-containing protein 4A
    Protein Accession:
    Q9H788
    Secondary Accessions:
    • B4DDR1
    • Q5XKC1
    • Q6NXE9
    • Q86YM2
    • Q96C88
    • Q9H7F7

    Protein attributes for SH2D4A Gene

    Size:
    454 amino acids
    Molecular mass:
    52727 Da
    Quaternary structure:
    • Interacts with ESR1.
    SequenceCaution:
    • Sequence=AAH67117.1; Type=Frameshift; Positions=392; Evidence={ECO:0000305}; Sequence=AAO41715.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO41715.1; Type=Erroneous termination; Positions=455; Note=Translated as stop.; Evidence={ECO:0000305}; Sequence=BAB14935.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SH2D4A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH2D4A Gene

Proteomics data for SH2D4A Gene at MOPED

Post-translational modifications for SH2D4A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH2D4A Gene

No data available for DME Specific Peptides for SH2D4A Gene

Domains for SH2D4A Gene

Gene Families for SH2D4A Gene

HGNC:
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits
  • SH2D :SH2 domain containing

Protein Domains for SH2D4A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SH2D4A Gene

Graphical View of Domain Structure for InterPro Entry

Q9H788

UniProtKB/Swiss-Prot:

SH24A_HUMAN :
  • Q9H788
Domain:
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SH2D4A: view

Function for SH2D4A Gene

Molecular function for SH2D4A Gene

UniProtKB/Swiss-Prot Function: Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function.

Gene Ontology (GO) - Molecular Function for SH2D4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0019902 phosphatase binding IDA 19389623
genes like me logo Genes that share ontologies with SH2D4A: view

Phenotypes for SH2D4A Gene

genes like me logo Genes that share phenotypes with SH2D4A: view

Animal Models for SH2D4A Gene

MGI Knock Outs for SH2D4A:

Animal Model Products

CRISPR Products

miRNA for SH2D4A Gene

miRTarBase miRNAs that target SH2D4A

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SH2D4A Gene

Localization for SH2D4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH2D4A Gene

Cytoplasm. Note=Located at podocyte foot processes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SH2D4A Gene COMPARTMENTS Subcellular localization image for SH2D4A gene
Compartment Confidence
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for SH2D4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with SH2D4A: view

Pathways for SH2D4A Gene

SuperPathways for SH2D4A Gene

No Data Available

Gene Ontology (GO) - Biological Process for SH2D4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with SH2D4A: view

No data available for Pathways by source for SH2D4A Gene

Transcripts for SH2D4A Gene

Unigene Clusters for SH2D4A Gene

SH2 domain containing 4A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SH2D4A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SH2D4A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D4A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b
SP1: - - -
SP2: - -
SP3: -
SP4:
SP5:

Relevant External Links for SH2D4A Gene

GeneLoc Exon Structure for
SH2D4A
ECgene alternative splicing isoforms for
SH2D4A

Expression for SH2D4A Gene

mRNA expression in normal human tissues for SH2D4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH2D4A Gene

This gene is overexpressed in Esophagus - Mucosa (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SH2D4A Gene

SOURCE GeneReport for Unigene cluster for SH2D4A Gene Hs.303208

mRNA Expression by UniProt/SwissProt for SH2D4A Gene

Q9H788-SH24A_HUMAN
Tissue specificity: Ubiquitously expressed. Aberrantly expressed in some cancers.
genes like me logo Genes that share expressions with SH2D4A: view

In Situ Assay Products

Orthologs for SH2D4A Gene

This gene was present in the common ancestor of animals.

Orthologs for SH2D4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SH2D4A 35
  • 98.46 (n)
  • 97.8 (a)
SH2D4A 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SH2D4A 35
  • 78 (n)
  • 74.22 (a)
SH2D4A 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SH2D4A 35
  • 85.21 (n)
  • 83.89 (a)
SH2D4A 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sh2d4a 35
  • 79.33 (n)
  • 78.15 (a)
Sh2d4a 16
Sh2d4a 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SH2D4A 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SH2D4A 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sh2d4a 35
  • 80.25 (n)
  • 78.67 (a)
chicken
(Gallus gallus)
Aves SH2D4A 35
  • 64.65 (n)
  • 61.07 (a)
SH2D4A 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SH2D4A 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sh2d4a 35
  • 57.88 (n)
  • 53.18 (a)
zebrafish
(Danio rerio)
Actinopterygii sh2d4a 35
  • 58.02 (n)
  • 53.44 (a)
sh2d4a 36
  • 46 (a)
OneToOne
zgc56186 35
worm
(Caenorhabditis elegans)
Secernentea F13B12.6 35
  • 48.66 (n)
  • 40.9 (a)
F13B12.6 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for SH2D4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH2D4A Gene

ENSEMBL:
Gene Tree for SH2D4A (if available)
TreeFam:
Gene Tree for SH2D4A (if available)

Paralogs for SH2D4A Gene

Paralogs for SH2D4A Gene

Selected SIMAP similar genes for SH2D4A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SH2D4A: view

Variants for SH2D4A Gene

Sequence variations from dbSNP and Humsavar for SH2D4A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs877386 - 19,364,153(+) CCTCG(C/G)GGCCC missense, reference
rs1316901 -- 19,343,098(+) CATAA(A/C)CCTCT intron-variant
rs1317067 -- 19,374,664(-) AGAGA(A/C/T)GCCAG intron-variant
rs1317827 -- 19,364,428(+) TCTAA(A/G)CCTTC intron-variant
rs1320326 -- 19,384,459(-) ATGGG(C/T)GTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH2D4A Gene

Variant ID Type Subtype PubMed ID
dgv7748n71 CNV Gain 21882294
nsv522185 CNV Gain 19592680
dgv7750n71 CNV Gain 21882294
nsv890621 CNV Loss 21882294
nsv398156 CNV Loss 16902084
nsv6103 CNV Insertion 18451855
nsv523271 CNV Loss 19592680
nsv528004 CNV Loss 19592680
nsv890622 CNV Gain 21882294
esv1003522 CNV Deletion 20482838
esv1412941 CNV Deletion 17803354
nsv522774 CNV Loss 19592680
esv34007 CNV Loss 18971310

Relevant External Links for SH2D4A Gene

HapMap Linkage Disequilibrium report
SH2D4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH2D4A Gene

Disorders for SH2D4A Gene

Relevant External Links for SH2D4A

Genetic Association Database (GAD)
SH2D4A
Human Genome Epidemiology (HuGE) Navigator
SH2D4A
genes like me logo Genes that share disorders with SH2D4A: view

No data available for UniProtKB/Swiss-Prot for SH2D4A Gene

Publications for SH2D4A Gene

  1. A novel member of SH(2) signaling protein family: cloning and characterization of SH(2)A gene. (PMID: 12476414) Dai S. … Ding Q. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2002) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. Genetic analysis of SH2D4A, a novel adapter protein related to T cell-specific adapter and adapter protein in lymphocytes of unknown function, reveals a redundant function in T cells. (PMID: 18641339) Lapinski P.E. … King P.D. (J. Immunol. 2008) 3 4

Products for SH2D4A Gene

Sources for SH2D4A Gene

Back to Top

Content