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Aliases for SH2D4A Gene

Aliases for SH2D4A Gene

  • SH2 Domain Containing 4A 2 3 5
  • Protein Phosphatase 1 Regulatory Subunit 38 3 4
  • Protein SH(2)A 3 4
  • PPP1R38 3 4
  • SH2A 3 4
  • Protein Phosphatase 1, Regulatory Subunit 38 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 38 2

External Ids for SH2D4A Gene

Previous GeneCards Identifiers for SH2D4A Gene

  • GC08P019182
  • GC08P019215
  • GC08P017711

Summaries for SH2D4A Gene

GeneCards Summary for SH2D4A Gene

SH2D4A (SH2 Domain Containing 4A) is a Protein Coding gene. GO annotations related to this gene include phosphatase binding. An important paralog of this gene is HSH2D.

UniProtKB/Swiss-Prot for SH2D4A Gene

  • Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function.

Gene Wiki entry for SH2D4A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2D4A Gene

Genomics for SH2D4A Gene

Regulatory Elements for SH2D4A Gene

Enhancers for SH2D4A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SH2D4A on UCSC Golden Path with GeneCards custom track

Promoters for SH2D4A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SH2D4A on UCSC Golden Path with GeneCards custom track

Genomic Location for SH2D4A Gene

19,313,443 bp from pter
19,396,218 bp from pter
82,776 bases
Plus strand

Genomic View for SH2D4A Gene

Genes around SH2D4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH2D4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH2D4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D4A Gene

Proteins for SH2D4A Gene

  • Protein details for SH2D4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH2 domain-containing protein 4A
    Protein Accession:
    Secondary Accessions:
    • B4DDR1
    • Q5XKC1
    • Q6NXE9
    • Q86YM2
    • Q96C88
    • Q9H7F7

    Protein attributes for SH2D4A Gene

    454 amino acids
    Molecular mass:
    52727 Da
    Quaternary structure:
    • Interacts with ESR1.
    • Sequence=AAH67117.1; Type=Frameshift; Positions=392; Evidence={ECO:0000305}; Sequence=AAO41715.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO41715.1; Type=Erroneous termination; Positions=455; Note=Translated as stop.; Evidence={ECO:0000305}; Sequence=BAB14935.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SH2D4A Gene


neXtProt entry for SH2D4A Gene

Proteomics data for SH2D4A Gene at MOPED

Post-translational modifications for SH2D4A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH2D4A Gene

No data available for DME Specific Peptides for SH2D4A Gene

Domains & Families for SH2D4A Gene

Protein Domains for SH2D4A Gene


Suggested Antigen Peptide Sequences for SH2D4A Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SH2 domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SH2D4A: view

Function for SH2D4A Gene

Molecular function for SH2D4A Gene

UniProtKB/Swiss-Prot Function:
Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function.
genes like me logo Genes that share phenotypes with SH2D4A: view

Animal Models for SH2D4A Gene

MGI Knock Outs for SH2D4A:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SH2D4A Gene

Localization for SH2D4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH2D4A Gene

Cytoplasm. Note=Located at podocyte foot processes. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for SH2D4A Gene COMPARTMENTS Subcellular localization image for SH2D4A gene
Compartment Confidence
cytosol 4
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for SH2D4A Gene

Pathways & Interactions for SH2D4A Gene

SuperPathways for SH2D4A Gene

No Data Available

Gene Ontology (GO) - Biological Process for SH2D4A Gene


No data available for Pathways by source and SIGNOR curated interactions for SH2D4A Gene

Drugs & Compounds for SH2D4A Gene

No Compound Related Data Available

Transcripts for SH2D4A Gene

Unigene Clusters for SH2D4A Gene

SH2 domain containing 4A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D4A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b
SP1: - - -
SP2: - -
SP3: -

Relevant External Links for SH2D4A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH2D4A Gene

mRNA expression in normal human tissues for SH2D4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH2D4A Gene

This gene is overexpressed in Esophagus - Mucosa (x4.0).

Protein differential expression in normal tissues from HIPED for SH2D4A Gene

This gene is overexpressed in Adrenal (15.6), Pancreas (10.2), Plasma (7.7), and Islet of Langerhans (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SH2D4A Gene

SOURCE GeneReport for Unigene cluster for SH2D4A Gene Hs.303208

mRNA Expression by UniProt/SwissProt for SH2D4A Gene

Tissue specificity: Ubiquitously expressed. Aberrantly expressed in some cancers.
genes like me logo Genes that share expression patterns with SH2D4A: view

Primer Products

No data available for Protein tissue co-expression partners for SH2D4A Gene

Orthologs for SH2D4A Gene

This gene was present in the common ancestor of animals.

Orthologs for SH2D4A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SH2D4A 35
  • 78 (n)
  • 74.22 (a)
SH2D4A 36
  • 74 (a)
(Canis familiaris)
Mammalia SH2D4A 35
  • 85.21 (n)
  • 83.89 (a)
SH2D4A 36
  • 84 (a)
(Mus musculus)
Mammalia Sh2d4a 35
  • 79.33 (n)
  • 78.15 (a)
Sh2d4a 16
Sh2d4a 36
  • 78 (a)
(Pan troglodytes)
Mammalia SH2D4A 35
  • 98.46 (n)
  • 97.8 (a)
SH2D4A 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Sh2d4a 35
  • 80.25 (n)
  • 78.67 (a)
(Monodelphis domestica)
Mammalia SH2D4A 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia SH2D4A 36
  • 66 (a)
(Gallus gallus)
Aves SH2D4A 35
  • 64.65 (n)
  • 61.07 (a)
SH2D4A 36
  • 57 (a)
(Anolis carolinensis)
Reptilia SH2D4A 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sh2d4a 35
  • 57.88 (n)
  • 53.18 (a)
(Danio rerio)
Actinopterygii sh2d4a 35
  • 58.02 (n)
  • 53.44 (a)
zgc56186 35
sh2d4a 36
  • 46 (a)
(Caenorhabditis elegans)
Secernentea F13B12.6 35
  • 48.66 (n)
  • 40.9 (a)
F13B12.6 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for SH2D4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH2D4A Gene

Gene Tree for SH2D4A (if available)
Gene Tree for SH2D4A (if available)

Paralogs for SH2D4A Gene

Paralogs for SH2D4A Gene

(1) SIMAP similar genes for SH2D4A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SH2D4A: view

Variants for SH2D4A Gene

Sequence variations from dbSNP and Humsavar for SH2D4A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_026055 -
VAR_026056 -
VAR_051350 -
VAR_051351 -
rs2139759 -- 19,336,914(+) AATTA(A/C)AGTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH2D4A Gene

Variant ID Type Subtype PubMed ID
dgv7748n71 CNV Gain 21882294
nsv522185 CNV Gain 19592680
dgv7750n71 CNV Gain 21882294
nsv890621 CNV Loss 21882294
nsv398156 CNV Loss 16902084
nsv6103 CNV Insertion 18451855
nsv523271 CNV Loss 19592680
nsv528004 CNV Loss 19592680
nsv890622 CNV Gain 21882294
esv1003522 CNV Deletion 20482838
esv1412941 CNV Deletion 17803354
nsv522774 CNV Loss 19592680
esv34007 CNV Loss 18971310

Variation tolerance for SH2D4A Gene

Residual Variation Intolerance Score: 23.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.17; 92.36% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SH2D4A Gene

Disorders for SH2D4A Gene

Relevant External Links for SH2D4A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SH2D4A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH2D4A Gene

Publications for SH2D4A Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for SH2D4A Gene

Sources for SH2D4A Gene